메뉴 건너뛰기




Volumn 548, Issue 7667, 2017, Pages 297-303

Integrative clinical genomics of metastatic cancer

(33)  Robinson, Dan R a,b   Wu, Yi Mi a,b   Lonigro, Robert J a   Vats, Pankaj a   Cobain, Erin b   Everett, Jessica b   Cao, Xuhong a   Rabban, Erica a   Kumar Sinha, Chandan a,b   Raymond, Victoria b   Schuetze, Scott b   Alva, Ajjai b   Siddiqui, Javed a,b   Chugh, Rashmi b   Worden, Francis b   Zalupski, Mark M b   Innis, Jeffrey b   Mody, Rajen J b   Tomlins, Scott A a,b   Lucas, David b   more..


Author keywords

[No Author keywords available]

Indexed keywords

CDKN2A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 2C; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PIK3CA PROTEIN, HUMAN; PROTEIN P53; PTEN PROTEIN, HUMAN; RB1 PROTEIN, HUMAN; RETINOBLASTOMA BINDING PROTEIN; TP53 PROTEIN, HUMAN; TRANSCRIPTOME; UBIQUITIN PROTEIN LIGASE;

EID: 85027893400     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature23306     Document Type: Article
Times cited : (652)

References (45)
  • 1
    • 33745684527 scopus 로고    scopus 로고
    • Metastasis: A question of life or death
    • Mehlen, P. & Puisieux, A. Metastasis: a question of life or death. Nat. Rev. Cancer 6, 449-458 (2006).
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 449-458
    • Mehlen, P.1    Puisieux, A.2
  • 2
    • 84962210751 scopus 로고    scopus 로고
    • Targeting metastasis
    • Steeg, P. S. Targeting metastasis. Nat. Rev. Cancer 16, 201-218 (2016).
    • (2016) Nat. Rev. Cancer , vol.16 , pp. 201-218
    • Steeg, P.S.1
  • 3
    • 84948716424 scopus 로고    scopus 로고
    • Precision medicine for cancer with next-generation functional diagnostics
    • Friedman, A. A., Letai, A., Fisher, D. E. & Flaherty, K. T. Precision medicine for cancer with next-generation functional diagnostics. Nat. Rev. Cancer 15, 747-756 (2015).
    • (2015) Nat. Rev. Cancer , vol.15 , pp. 747-756
    • Friedman, A.A.1    Letai, A.2    Fisher, D.E.3    Flaherty, K.T.4
  • 4
    • 84899974241 scopus 로고    scopus 로고
    • The integration of next-generation sequencing panels in the clinical cancer genetics practice: An institutional experience
    • Mauer, C. B., Pirzadeh-Miller, S. M., Robinson, L. D. & Euhus, D. M. The integration of next-generation sequencing panels in the clinical cancer genetics practice: an institutional experience. Genet. Med. 16, 407-412 (2014).
    • (2014) Genet. Med. , vol.16 , pp. 407-412
    • Mauer, C.B.1    Pirzadeh-Miller, S.M.2    Robinson, L.D.3    Euhus, D.M.4
  • 5
    • 84940109321 scopus 로고    scopus 로고
    • Clinical applications of next generation sequencing in cancer: From panels, to exomes, to genomes. Front
    • Shen, T., Pajaro-Van de Stadt, S. H., Yeat, N. C. & Lin, J. C. Clinical applications of next generation sequencing in cancer: from panels, to exomes, to genomes. Front. Genet. 6, 215 (2015).
    • (2015) Genet. , vol.6 , pp. 215
    • Shen, T.1    Pajaro-Van De Stadt, S.H.2    Yeat, N.C.3    Lin, J.C.4
  • 6
    • 84928248330 scopus 로고    scopus 로고
    • Personalized genomic analyses for cancer mutation discovery and interpretation
    • Jones, S. et al. Personalized genomic analyses for cancer mutation discovery and interpretation. Sci. Transl. Med. 7, 283ra53 (2015).
    • (2015) Sci. Transl. Med. , vol.7 , pp. 283ra53
    • Jones, S.1
  • 7
    • 82655184653 scopus 로고    scopus 로고
    • Personalized oncology through integrative highthroughput sequencing: A pilot study
    • Roychowdhury, S. et al. Personalized oncology through integrative highthroughput sequencing: a pilot study. Sci. Transl. Med. 3, 111ra121 (2011).
    • (2011) Sci. Transl. Med. , vol.3 , pp. 111ra121
    • Roychowdhury, S.1
  • 9
    • 84963585216 scopus 로고    scopus 로고
    • Metastasis as an evolutionary process
    • Turajlic, S. & Swanton, C. Metastasis as an evolutionary process. Science 352, 169-175 (2016).
    • (2016) Science , vol.352 , pp. 169-175
    • Turajlic, S.1    Swanton, C.2
  • 10
    • 84930225081 scopus 로고    scopus 로고
    • Integrative clinical genomics of advanced prostate cancer
    • Robinson, D. et al. Integrative clinical genomics of advanced prostate cancer. Cell 161, 1215-1228 (2015).
    • (2015) Cell , vol.161 , pp. 1215-1228
    • Robinson, D.1
  • 11
    • 84884994218 scopus 로고    scopus 로고
    • The Cancer Genome Atlas Research Network, et al. The Cancer Genome Atlas Pan-Cancer analysis project
    • The Cancer Genome Atlas Research Network, et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nat. Genet. 45, 1113-1120 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 1113-1120
  • 12
    • 84938197903 scopus 로고    scopus 로고
    • Next-generation sequencing to guide cancer therapy
    • Gagan, J. & Van Allen, E. M. Next-generation sequencing to guide cancer therapy. Genome Med. 7, 80 (2015).
    • (2015) Genome Med. , vol.7 , pp. 80
    • Gagan, J.1    Van Allen, E.M.2
  • 13
    • 84899044610 scopus 로고    scopus 로고
    • The translation of cancer genomics: Time for a revolution in clinical cancer care
    • Mardis, E. R. The translation of cancer genomics: time for a revolution in clinical cancer care. Genome Med. 6, 22 (2014).
    • (2014) Genome Med. , vol.6 , pp. 22
    • Mardis, E.R.1
  • 14
    • 85010703579 scopus 로고    scopus 로고
    • Diagnostic yield of clinical tumor and germline wholeexome sequencing for children with solid tumors
    • Parsons, D. W. et al. Diagnostic yield of clinical tumor and germline wholeexome sequencing for children with solid tumors. J. Am. Med. Assoc. Oncol. 2, 616-624 (2016).
    • (2016) J. Am. Med. Assoc. Oncol. , vol.2 , pp. 616-624
    • Parsons, D.W.1
  • 15
    • 84940769044 scopus 로고    scopus 로고
    • Integrative clinical sequencing in the management of refractory or relapsed cancer in youth
    • Mody, R. J. et al. Integrative clinical sequencing in the management of refractory or relapsed cancer in youth. J. Am. Med. Assoc. 314, 913-925 (2015).
    • (2015) J. Am. Med. Assoc. , vol.314 , pp. 913-925
    • Mody, R.J.1
  • 16
    • 84865833740 scopus 로고    scopus 로고
    • High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing
    • Wagle, N. et al. High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. Cancer Discov. 2, 82-93 (2012).
    • (2012) Cancer Discov. , vol.2 , pp. 82-93
    • Wagle, N.1
  • 17
    • 84982797286 scopus 로고    scopus 로고
    • Inherited DNA-repair gene mutations in men with metastatic prostate cancer
    • Pritchard, C. C. et al. Inherited DNA-repair gene mutations in men with metastatic prostate cancer. N. Engl. J. Med. 375, 443-453 (2016).
    • (2016) N. Engl. J. Med. , vol.375 , pp. 443-453
    • Pritchard, C.C.1
  • 18
    • 77954526989 scopus 로고    scopus 로고
    • Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma
    • Palanisamy, N. et al. Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. Nat. Med. 16, 793-798 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 793-798
    • Palanisamy, N.1
  • 19
    • 84856091317 scopus 로고    scopus 로고
    • Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer
    • Robinson, D. R. et al. Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Nat. Med. 17, 1646-1651 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 1646-1651
    • Robinson, D.R.1
  • 21
    • 84898810236 scopus 로고    scopus 로고
    • Extraskeletal myxoid chondrosarcoma with non-EWSR1-NR4A3 variant fusions correlate with rhabdoid phenotype and high-grade morphology
    • Agaram, N. P., Zhang, L., Sung, Y. S., Singer, S. & Antonescu, C. R. Extraskeletal myxoid chondrosarcoma with non-EWSR1-NR4A3 variant fusions correlate with rhabdoid phenotype and high-grade morphology. Hum. Pathol. 45, 1084-1091 (2014).
    • (2014) Hum. Pathol. , vol.45 , pp. 1084-1091
    • Agaram, N.P.1    Zhang, L.2    Sung, Y.S.3    Singer, S.4    Antonescu, C.R.5
  • 22
    • 84905718622 scopus 로고    scopus 로고
    • Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin
    • Weinreb, I. et al. Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin. Genes Chromosom. Cancer 53, 845-856 (2014).
    • (2014) Genes Chromosom. Cancer , vol.53 , pp. 845-856
    • Weinreb, I.1
  • 23
    • 84880280631 scopus 로고    scopus 로고
    • ViSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia
    • Amir, A. D. et al. viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia. Nat. Biotechnol. 31, 545-552 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 545-552
    • Amir, A.D.1
  • 24
    • 84878682420 scopus 로고    scopus 로고
    • The Genotype-Tissue Expression (GTEx) project
    • Lonsdale, J. et al. The Genotype-Tissue Expression (GTEx) project. Nat. Genet. 45, 580-585 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 580-585
    • Lonsdale, J.1
  • 25
    • 84955328286 scopus 로고    scopus 로고
    • The Molecular Signatures Database hallmark gene set collection
    • Liberzon, A. et al. The Molecular Signatures Database hallmark gene set collection. Cell Syst. 1, 417-425 (2015).
    • (2015) Cell Syst. , vol.1 , pp. 417-425
    • Liberzon, A.1
  • 26
    • 79958135926 scopus 로고    scopus 로고
    • Molecular signatures database (MSigDB) 3.0
    • Liberzon, A. et al. Molecular signatures database (MSigDB) 3.0. Bioinformatics 27, 1739-1740 (2011).
    • (2011) Bioinformatics , vol.27 , pp. 1739-1740
    • Liberzon, A.1
  • 27
    • 84872202078 scopus 로고    scopus 로고
    • Gene set variation analysis for microarray and RNA-seq data
    • Hänzelmann, S., Castelo, R. & Guinney, J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics 14, 7 (2013).
    • (2013) BMC Bioinformatics , vol.14 , pp. 7
    • Hänzelmann, S.1    Castelo, R.2    Gsva, G.J.3
  • 28
    • 77954195272 scopus 로고    scopus 로고
    • Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM
    • Vaske, C. J. et al. Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM. Bioinformatics 26, i237-i245 (2010).
    • (2010) Bioinformatics , vol.26 , pp. i237-i245
    • Vaske, C.J.1
  • 29
    • 70450142560 scopus 로고    scopus 로고
    • Inflammation and EMT: An alliance towards organ fibrosis and cancer progression
    • López-Novoa, J. M. & Nieto, M. A. Inflammation and EMT: an alliance towards organ fibrosis and cancer progression. EMBO Mol. Med. 1, 303-314 (2009).
    • (2009) EMBO Mol. Med. , vol.1 , pp. 303-314
    • López-Novoa, J.M.1    Nieto, M.A.2
  • 30
    • 84885673911 scopus 로고    scopus 로고
    • Inferring tumour purity and stromal and immune cell admixture from expression data
    • Yoshihara, K. et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat. Commun. 4, 2612 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 2612
    • Yoshihara, K.1
  • 31
    • 70350537020 scopus 로고    scopus 로고
    • Simultaneous infiltration of polyfunctional effector and suppressor T cells into renal cell carcinomas
    • Attig, S. et al. Simultaneous infiltration of polyfunctional effector and suppressor T cells into renal cell carcinomas. Cancer Res. 69, 8412-8419 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 8412-8419
    • Attig, S.1
  • 32
    • 0035394233 scopus 로고    scopus 로고
    • Proliferative activity of intratumoral CD8+ T-lymphocytes as a prognostic factor in human renal cell carcinoma: Clinicopathologic demonstration of antitumor immunity
    • Nakano, O. et al. Proliferative activity of intratumoral CD8+ T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity. Cancer Res. 61, 5132-5136 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 5132-5136
    • Nakano, O.1
  • 33
    • 58249134743 scopus 로고    scopus 로고
    • Clinical significance of tumor-infiltrating lymphocytes in lung neoplasms
    • Ruffini, E. et al. Clinical significance of tumor-infiltrating lymphocytes in lung neoplasms. Ann. Thorac. Surg. 87, 365-371 (2009).
    • (2009) Ann. Thorac. Surg. , vol.87 , pp. 365-371
    • Ruffini, E.1
  • 35
    • 84928927858 scopus 로고    scopus 로고
    • Robust enumeration of cell subsets from tissue expression profiles
    • Newman, A. M. et al. Robust enumeration of cell subsets from tissue expression profiles. Nat. Methods 12, 453-457 (2015).
    • (2015) Nat. Methods , vol.12 , pp. 453-457
    • Newman, A.M.1
  • 36
    • 33645991795 scopus 로고    scopus 로고
    • Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy
    • Sica, A., Schioppa, T., Mantovani, A. & Allavena, P. Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur. J. Cancer 42, 717-727 (2006).
    • (2006) Eur. J. Cancer , vol.42 , pp. 717-727
    • Sica, A.1    Schioppa, T.2    Mantovani, A.3    Allavena, P.4
  • 37
    • 84935474357 scopus 로고    scopus 로고
    • PD-L1 expression as a predictive biomarker in cancer immunotherapy
    • Patel, S. P. & Kurzrock, R. PD-L1 expression as a predictive biomarker in cancer immunotherapy. Mol. Cancer Ther. 14, 847-856 (2015).
    • (2015) Mol. Cancer Ther. , vol.14 , pp. 847-856
    • Patel, S.P.1    Kurzrock, R.2
  • 38
    • 46049103179 scopus 로고    scopus 로고
    • Favorable outcome in clinically stage II melanoma patients is associated with the presence of activated tumor infiltrating T-lymphocytes and preserved MHC class i antigen expression
    • van Houdt, I. S. et al. Favorable outcome in clinically stage II melanoma patients is associated with the presence of activated tumor infiltrating T-lymphocytes and preserved MHC class I antigen expression. Int. J. Cancer 123, 609-615 (2008).
    • (2008) Int. J. Cancer , vol.123 , pp. 609-615
    • Van Houdt, I.S.1
  • 39
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon, J. et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313, 1960-1964 (2006).
    • (2006) Science , vol.313 , pp. 1960-1964
    • Galon, J.1
  • 40
    • 84928761118 scopus 로고    scopus 로고
    • Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi, N. A. et al. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348, 124-128 (2015).
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1
  • 41
    • 84880720167 scopus 로고    scopus 로고
    • Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy
    • Ulloa-Montoya, F. et al. Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy. J. Clin. Oncol. 31, 2388-2395 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 2388-2395
    • Ulloa-Montoya, F.1
  • 42
    • 84946019429 scopus 로고    scopus 로고
    • DNA-repair defects and olaparib in metastatic prostate cancer
    • Mateo, J. et al. DNA-repair defects and olaparib in metastatic prostate cancer. N. Engl. J. Med. 373, 1697-1708 (2015).
    • (2015) N. Engl. J. Med. , vol.373 , pp. 1697-1708
    • Mateo, J.1
  • 44
    • 84941002648 scopus 로고    scopus 로고
    • The use of exome capture RNA-seq for highly degraded RNA with application to clinical cancer sequencing
    • Cieślik, M. et al. The use of exome capture RNA-seq for highly degraded RNA with application to clinical cancer sequencing. Genome Res. 25, 1372-1381 (2015).
    • (2015) Genome Res. , vol.25 , pp. 1372-1381
    • Cieślik, M.1
  • 45
    • 84930146714 scopus 로고    scopus 로고
    • MAGI: Visualization and collaborative annotation of genomic aberrations
    • Leiserson, M. D. et al. MAGI: visualization and collaborative annotation of genomic aberrations. Nat. Methods 12, 483-484 (2015).
    • (2015) Nat. Methods , vol.12 , pp. 483-484
    • Leiserson, M.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.