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Volumn 1, Issue 1, 1999, Pages 45-50

Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; NOCODAZOLE; PACLITAXEL; RAC1 PROTEIN;

EID: 0033130049     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/9018     Document Type: Article
Times cited : (410)

References (36)
  • 1
    • 0025782209 scopus 로고
    • Cell locomotion: New research tests old ideas on membrane and cytoskeletal flow
    • Heath, J. P. & Holifield, B. F. Cell locomotion: new research tests old ideas on membrane and cytoskeletal flow. Cell Motil. Cytoskeleton 18, 245-257 (1991).
    • (1991) Cell Motil. Cytoskeleton , vol.18 , pp. 245-257
    • Heath, J.P.1    Holifield, B.F.2
  • 2
    • 0030049170 scopus 로고    scopus 로고
    • Actin-based cell motilityand cell locomotion
    • Mitchison, T. J. & Cramer, L. P. Actin-based cell motilityand cell locomotion. Cell 84, 371-379 (1996).
    • (1996) Cell , vol.84 , pp. 371-379
    • Mitchison, T.J.1    Cramer, L.P.2
  • 4
    • 0014873873 scopus 로고
    • Effect of colcemid on the locomotory behaviour of fibroblasts
    • Vasiliev, J. M. et al. Effect of colcemid on the locomotory behaviour of fibroblasts. J. Embryol. Exp. Morph. 24, 625-690 (1970).
    • (1970) J. Embryol. Exp. Morph. , vol.24 , pp. 625-690
    • Vasiliev, J.M.1
  • 5
    • 0025741269 scopus 로고
    • Pseudopodial activity at the active edge of migrating fibroblast is decreased after drug-induced microtubule depolymerization
    • Bershadsky, A. D., Vaisberg, E. A. & Vasiliev, J. M. Pseudopodial activity at the active edge of migrating fibroblast is decreased after drug-induced microtubule depolymerization. Cell Motil. Cytoskeleton 19, 152-158 (1991).
    • (1991) Cell Motil. Cytoskeleton , vol.19 , pp. 152-158
    • Bershadsky, A.D.1    Vaisberg, E.A.2    Vasiliev, J.M.3
  • 6
    • 0026089520 scopus 로고
    • Polarization of pseudopodial activities: Cytoskeletal mechanisms
    • Vasiliev, J. M. Polarization of pseudopodial activities: cytoskeletal mechanisms. J. Cell Sci. 98, 1-4 (1991).
    • (1991) J. Cell Sci. , vol.98 , pp. 1-4
    • Vasiliev, J.M.1
  • 7
    • 0023851499 scopus 로고
    • Contact formation during fibroblast locomotion: Involvement of membrane ruffles and microtubules
    • Rinnerthaler, G., Geiger, B. & Small, J. Contact formation during fibroblast locomotion: involvement of membrane ruffles and microtubules. J. Cell Biol. 106, 747-760 (1988).
    • (1988) J. Cell Biol. , vol.106 , pp. 747-760
    • Rinnerthaler, G.1    Geiger, B.2    Small, J.3
  • 8
    • 0027723051 scopus 로고
    • Microtubule-dependent control of cell shape and pseudopodial activity is inhibited by the antibody to kinesin motor domain
    • Rodionov, V. I. et al. Microtubule-dependent control of cell shape and pseudopodial activity is inhibited by the antibody to kinesin motor domain. J. Cell Biol. 123, 1811-1820 (1993).
    • (1993) J. Cell Biol. , vol.123 , pp. 1811-1820
    • Rodionov, V.I.1
  • 9
    • 0030584089 scopus 로고    scopus 로고
    • Getting membrane flow and the cytoskeleton to cooperate
    • Bretscher, M. S. Getting membrane flow and the cytoskeleton to cooperate. Cell 87, 601-606 (1996).
    • (1996) Cell , vol.87 , pp. 601-606
    • Bretscher, M.S.1
  • 10
    • 0022854872 scopus 로고
    • The directed migration of eukaryotic cells
    • Singer, S. J. & Kupfer, A. The directed migration of eukaryotic cells. Annu. Rev. Cell Biol. 2, 337-365 (1986).
    • (1986) Annu. Rev. Cell Biol. , vol.2 , pp. 337-365
    • Singer, S.J.1    Kupfer, A.2
  • 11
    • 0028857104 scopus 로고
    • Low concentrations of nocodazole interfere with fibroblast locomotion without significantly affecting microtubule level: Implications for the role of dynamic microtubules in cell locomotion
    • Liao, G., Nagasaki, T. & Gundersen, G. G. Low concentrations of nocodazole interfere with fibroblast locomotion without significantly affecting microtubule level: implications for the role of dynamic microtubules in cell locomotion J. Cell Sci. 108, 3473-3483 (1995).
    • (1995) J. Cell Sci. , vol.108 , pp. 3473-3483
    • Liao, G.1    Nagasaki, T.2    Gundersen, G.G.3
  • 12
    • 0030727892 scopus 로고    scopus 로고
    • Actomyosin-based retrograde flow of microtubules in the lamella of migrating epithelial cells influences microtubule dynamic instability and turnover and is associated with microtubule breakage and treadmilling
    • Waterman-Storer, C. M. & Salmon, E. D. Actomyosin-based retrograde flow of microtubules in the lamella of migrating epithelial cells influences microtubule dynamic instability and turnover and is associated with microtubule breakage and treadmilling. J. Cell Biol. 139, 417-434 (1997).
    • (1997) J. Cell Biol. , vol.139 , pp. 417-434
    • Waterman-Storer, C.M.1    Salmon, E.D.2
  • 13
    • 0032559708 scopus 로고    scopus 로고
    • Cruising along microtubule highways: How membranes move through the secretory pathway
    • Bloom, G. S. & Goldstein, L. S. Cruising along microtubule highways: how membranes move through the secretory pathway. J. Cell Biol. 140, 1277-1280 (1998).
    • (1998) J. Cell Biol. , vol.140 , pp. 1277-1280
    • Bloom, G.S.1    Goldstein, L.S.2
  • 14
    • 0000297058 scopus 로고
    • Taxol stabilizes microtubules in mouse fibroblast cells
    • Schiff, P. B. & Horwitz, S. B. Taxol stabilizes microtubules in mouse fibroblast cells. Proc. Natl Acad. Sci. USA 77, 1561-1565 (1980).
    • (1980) Proc. Natl Acad. Sci. USA , vol.77 , pp. 1561-1565
    • Schiff, P.B.1    Horwitz, S.B.2
  • 15
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    • Ridley, A. J. Paterson, H. F., Johnston, C. L., Diekmann, D. & Hall, A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410 (1992).
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 16
    • 0030756973 scopus 로고    scopus 로고
    • Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganization
    • Machesky, L. M. & Hall, A. Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganization. J. Cell Biol. 138, 913-926 (1997).
    • (1997) J. Cell Biol. , vol.138 , pp. 913-926
    • Machesky, L.M.1    Hall, A.2
  • 17
    • 0030968580 scopus 로고    scopus 로고
    • Rho GTPases and signaling networks
    • Van Aelst, L. & D'Souza-Schorey, C. Rho GTPases and signaling networks. Genes Dev. 11, 2295-2322 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 2295-2322
    • Van Aelst, L.1    D'Souza-Schorey, C.2
  • 18
    • 0028837170 scopus 로고
    • Activation of the small GTP-binding proteins rho and rac by growth factor receptors
    • Nobes, C. D., Hawkins, P., Stephens, L. & Hall, A. Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J. Cell Sci. 108, 225-233 (1995).
    • (1995) J. Cell Sci. , vol.108 , pp. 225-233
    • Nobes, C.D.1    Hawkins, P.2    Stephens, L.3    Hall, A.4
  • 19
    • 0028961293 scopus 로고
    • Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • Nobes, C. D. & Hall, A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62 (1995).
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 21
    • 0028786020 scopus 로고
    • A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
    • Burbelo, P. D., Drechsel, D. & Hall, A. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J. Biol. Chem. 270, 29071-29074 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 29071-29074
    • Burbelo, P.D.1    Drechsel, D.2    Hall, A.3
  • 22
    • 0030040856 scopus 로고    scopus 로고
    • The Ras-related GTPase Rac1 binds tubulin
    • Best, A., Ahmed, S., Kozma, R. & L. Lim, L. The Ras-related GTPase Rac1 binds tubulin. J. Biol. Chem 271, 3756-3762 (1996).
    • (1996) J. Biol. Chem , vol.271 , pp. 3756-3762
    • Best, A.1    Ahmed, S.2    Kozma, R.3    L Lim, L.4
  • 23
    • 0032567341 scopus 로고    scopus 로고
    • Cloning and characterization of GFF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases
    • Ren, Y., Li, R., Zheng, Y. & Busch, H. Cloning and characterization of GFF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. J. Biol. Chem. 273, 34954-34960 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 34954-34960
    • Ren, Y.1    Li, R.2    Zheng, Y.3    Busch, H.4
  • 24
    • 0033555527 scopus 로고    scopus 로고
    • Phosphorylation- and actvitation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cb1 and Vav with tubulin in B-cells
    • Fernandez, J. A. et al. Phosphorylation- and actvitation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cb1 and Vav with tubulin in B-cells. J. Biol. Chem. 274, 1401-1406 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 1401-1406
    • Fernandez, J.A.1
  • 25
    • 0033593337 scopus 로고    scopus 로고
    • The Db1-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells
    • Glaven, J. A., Whitehead, I., Bagrodia, S., Kay, R. & Cerione, R. A. The Db1-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells. J. Biol. Chem 274, 2279-2285 (1999).
    • (1999) J. Biol. Chem , vol.274 , pp. 2279-2285
    • Glaven, J.A.1    Whitehead, I.2    Bagrodia, S.3    Kay, R.4    Cerione, R.A.5
  • 26
    • 0032472369 scopus 로고    scopus 로고
    • The MAP kinase kinase kinase MLK2 co-localizes with activated INK along microtubules and associates with kinesin superfamily motor KIF3
    • Nagata, K. et al. The MAP kinase kinase kinase MLK2 co-localizes with activated INK along microtubules and associates with kinesin superfamily motor KIF3. EMBO J. 17, 149-158 (1998).
    • (1998) EMBO J. , vol.17 , pp. 149-158
    • Nagata, K.1
  • 27
    • 0033582659 scopus 로고    scopus 로고
    • Clip-170 highlights growing microtubule ends in vivo
    • Perez, F., Diamantopoulos, G. S., Stalder, R. & Kreis, T. E. Clip-170 highlights growing microtubule ends in vivo. Cell 96, 517-552 (1999).
    • (1999) Cell , vol.96 , pp. 517-552
    • Perez, F.1    Diamantopoulos, G.S.2    Stalder, R.3    Kreis, T.E.4
  • 28
    • 0031815909 scopus 로고    scopus 로고
    • RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42 Hs
    • Gauthier-Rouviere, C. et al. RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42 Hs. Mol. Biol Cell 9, 1379-1394 (1998).
    • (1998) Mol. Biol Cell , vol.9 , pp. 1379-1394
    • Gauthier-Rouviere, C.1
  • 29
    • 0030462929 scopus 로고    scopus 로고
    • Microtubule disruption induces the formation of actin stress fibers and focal adhesions in cultured cells: Possible involvement of the Rho signal cascade
    • Enomoto, T. Microtubule disruption induces the formation of actin stress fibers and focal adhesions in cultured cells: possible involvement of the Rho signal cascade. Cell Struct. Funct. 21, 317-326 (1996).
    • (1996) Cell Struct. Funct. , vol.21 , pp. 317-326
    • Enomoto, T.1
  • 30
    • 0030928057 scopus 로고    scopus 로고
    • Lysophosphatidic acid and microtubule-destabilizing 'i agents stimulate fibronectin matrix assembly through Rho-dependent actin stress fiber formation and cell contraction
    • Zhang, Q., Magnusson, M. K. & Mosher, D. F. Lysophosphatidic acid and microtubule-destabilizing 'i agents stimulate fibronectin matrix assembly through Rho-dependent actin stress fiber formation and cell contraction. Mol. Biol. Cell 8, 1415-1425 (1997).
    • (1997) Mol. Biol. Cell , vol.8 , pp. 1415-1425
    • Zhang, Q.1    Magnusson, M.K.2    Mosher, D.F.3
  • 31
    • 0032454273 scopus 로고    scopus 로고
    • Microtubule depolymerization induces stress fibers, focal adhesions, and DNA synthesis via the GTP-binding protein Rho
    • Liu, B., Chrzanowska-Wodnicka, M. & Burridge, K. Microtubule depolymerization induces stress J fibers, focal adhesions, and DNA synthesis via the GTP-binding protein Rho. Cell Adhesion Commun. 5, 249-255 (1998).
    • (1998) Cell Adhesion Commun. , vol.5 , pp. 249-255
    • Liu, B.1    Chrzanowska-Wodnicka, M.2    Burridge, K.3
  • 32
    • 0033081753 scopus 로고    scopus 로고
    • Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
    • Ren, X.-D., Kiosses, W. B. & Schwartz, M. A. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J.. 18, 578-585 (1999).
    • (1999) EMBO J. , vol.18 , pp. 578-585
    • Ren, X.-D.1    Kiosses, W.B.2    Schwartz, M.A.3
  • 33
    • 0032966238 scopus 로고    scopus 로고
    • Positive feedback interactions between microtubule and actin dynamics during cell motility
    • Waterman-Storer, C. M. & Salmon, E. D. Positive feedback interactions between microtubule and actin dynamics during cell motility. Curr. Opin. Cell Biol. 11, 61-67 (1999).
    • (1999) Curr. Opin. Cell Biol. , vol.11 , pp. 61-67
    • Waterman-Storer, C.M.1    Salmon, E.D.2
  • 34
    • 0032488046 scopus 로고    scopus 로고
    • Fluorescent speckle microscopy, a method to visualize the dynamics of protein assemblies in living cells
    • Waterman-Storer, C. M., Desai, A., Bulinski, J. C. & Salmon, E. D. Fluorescent speckle microscopy, a method to visualize the dynamics of protein assemblies in living cells. Curr. Biol. 8, 1227-1230 (1998).
    • (1998) Curr. Biol. , vol.8 , pp. 1227-1230
    • Waterman-Storer, C.M.1    Desai, A.2    Bulinski, J.C.3    Salmon, E.D.4
  • 35
    • 0029164774 scopus 로고
    • Purification of recombinant Rho/Rac/G25K from Escherichia coli
    • Self, A. J. & Hall, A. Purification of recombinant Rho/Rac/G25K from Escherichia coli. Methods Enzymol. 256, 3-10 (1995).
    • (1995) Methods Enzymol. , vol.256 , pp. 3-10
    • Self, A.J.1    Hall, A.2
  • 36
    • 0031609116 scopus 로고    scopus 로고
    • A high-resolution multimode digital microscope system
    • Salmon, E. D. et al. A high-resolution multimode digital microscope system. Methods Cell Biol. 56, 185-215 (1998).
    • (1998) Methods Cell Biol. , vol.56 , pp. 185-215
    • Salmon, E.D.1


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