-
1
-
-
84896958063
-
Innate immune sensing and signaling of cytosolic nucleic acids
-
Wu, J. & Chen, Z. J. Innate immune sensing and signaling of cytosolic nucleic acids. Annu. Rev. Immunol. 32, 461-488 (2014)
-
(2014)
Annu. Rev. Immunol.
, vol.32
, pp. 461-488
-
-
Wu, J.1
Chen, Z.J.2
-
2
-
-
84873711885
-
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type i interferon pathway
-
Sun, L., Wu, J., Du, F., Chen, X. & Chen, Z. J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339, 786-791 (2013)
-
(2013)
Science
, vol.339
, pp. 786-791
-
-
Sun, L.1
Wu, J.2
Du, F.3
Chen, X.4
Chen, Z.J.5
-
3
-
-
84873724533
-
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
-
Wu, J. et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339, 826-830 (2013)
-
(2013)
Science
, vol.339
, pp. 826-830
-
-
Wu, J.1
-
4
-
-
84878309796
-
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
-
Gao, P. et al. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 153, 1094-1107 (2013)
-
(2013)
Cell
, vol.153
, pp. 1094-1107
-
-
Gao, P.1
-
5
-
-
84879385334
-
CGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING
-
Ablasser, A. et al. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature 498, 380-384 (2013)
-
(2013)
Nature
, vol.498
, pp. 380-384
-
-
Ablasser, A.1
-
6
-
-
84878572947
-
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING
-
Diner, E. J. et al. The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Rep. 3, 1355-1361 (2013)
-
(2013)
Cell Rep.
, vol.3
, pp. 1355-1361
-
-
Diner, E.J.1
-
7
-
-
84924778328
-
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
-
Liu, S. et al. Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347, aaa2630 (2015)
-
(2015)
Science
, vol.347
, pp. aaa2630
-
-
Liu, S.1
-
8
-
-
84912120595
-
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
-
Woo, S. R. et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 41, 830-842 (2014)
-
(2014)
Immunity
, vol.41
, pp. 830-842
-
-
Woo, S.R.1
-
9
-
-
84886789626
-
Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling
-
Konno, H., Konno, K. & Barber, G. N. Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 155, 688-698 (2013)
-
(2013)
Cell
, vol.155
, pp. 688-698
-
-
Konno, H.1
Konno, K.2
Barber, G.N.3
-
10
-
-
84885332714
-
STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease
-
Petrasek, J. et al. STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease. Proc. Natl Acad. Sci. USA 110, 16544-16549 (2013)
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 16544-16549
-
-
Petrasek, J.1
-
11
-
-
84886027402
-
Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis
-
Sze, A. et al. Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis. Cell Host. Microbe. 14, 422-434 (2013)
-
(2013)
Cell Host. Microbe.
, vol.14
, pp. 422-434
-
-
Sze, A.1
-
12
-
-
84970963467
-
Agonist-mediated activation of STING induces apoptosis in malignant B cells
-
Tang, C. H. et al. Agonist-mediated activation of STING induces apoptosis in malignant B cells. Cancer Res. 76, 2137-2152 (2016)
-
(2016)
Cancer Res.
, vol.76
, pp. 2137-2152
-
-
Tang, C.H.1
-
13
-
-
79251506939
-
The N-ethyl-N-nitrosourea-induced goldenticket mouse mutant reveals an essential function of sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides
-
Sauer, J. D. et al. The N-ethyl-N-nitrosourea-induced goldenticket mouse mutant reveals an essential function of sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect. Immun. 79, 688-694 (2011)
-
(2011)
Infect. Immun.
, vol.79
, pp. 688-694
-
-
Sauer, J.D.1
-
14
-
-
84878638162
-
Species-specific detection of the antiviral small-molecule compound CMA by STING
-
Cavlar, T., Deimling, T., Ablasser, A., Hopfner, K. P. & Hornung, V. Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J. 32, 1440-1450 (2013)
-
(2013)
EMBO J.
, vol.32
, pp. 1440-1450
-
-
Cavlar, T.1
Deimling, T.2
Ablasser, A.3
Hopfner, K.P.4
Hornung, V.5
-
15
-
-
0038021272
-
Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more
-
Marsden, V. S. & Strasser, A. Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu. Rev. Immunol. 21, 71-105 (2003)
-
(2003)
Annu. Rev. Immunol.
, vol.21
, pp. 71-105
-
-
Marsden, V.S.1
Strasser, A.2
-
16
-
-
84905825645
-
Activated STING in a vascular and pulmonary syndrome
-
Liu, Y. et al. Activated STING in a vascular and pulmonary syndrome. N. Engl. J. Med. 371, 507-518 (2014)
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 507-518
-
-
Liu, Y.1
-
17
-
-
84915745085
-
Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations
-
Jeremiah, N. et al. Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations. J. Clin. Invest. 124, 5516-5520 (2014)
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 5516-5520
-
-
Jeremiah, N.1
-
18
-
-
78649363017
-
Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation
-
Wendorff, A. A. et al. Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity 33, 671-684 (2010)
-
(2010)
Immunity
, vol.33
, pp. 671-684
-
-
Wendorff, A.A.1
-
19
-
-
80054966913
-
STING is a direct innate immune sensor of cyclic di-GMP
-
Burdette, D. L. et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature 478, 515-518 (2011)
-
(2011)
Nature
, vol.478
, pp. 515-518
-
-
Burdette, D.L.1
-
20
-
-
84941767986
-
Viruses transfer the antiviral second messenger cGAMP between cells
-
Bridgeman, A. et al. Viruses transfer the antiviral second messenger cGAMP between cells. Science 349, 1228-1232 (2015)
-
(2015)
Science
, vol.349
, pp. 1228-1232
-
-
Bridgeman, A.1
-
21
-
-
84941785319
-
Transmission of innate immune signaling by packaging of cGAMP in viral particles
-
Gentili, M. et al. Transmission of innate immune signaling by packaging of cGAMP in viral particles. Science 349, 1232-1236 (2015)
-
(2015)
Science
, vol.349
, pp. 1232-1236
-
-
Gentili, M.1
-
22
-
-
84948670572
-
STING: Infection, inflammation and cancer
-
Barber, G. N. STING: infection, inflammation and cancer. Nat. Rev. Immunol. 15, 760-770 (2015)
-
(2015)
Nat. Rev. Immunol.
, vol.15
, pp. 760-770
-
-
Barber, G.N.1
-
23
-
-
84966263763
-
The role of cGAS in innate immunity and beyond
-
Ablasser A. & Gulen M. F. The role of cGAS in innate immunity and beyond. J. Mol. Med. 94, 1085-1093 (2016)
-
(2016)
J. Mol. Med.
, vol.94
, pp. 1085-1093
-
-
Ablasser, A.1
Gulen, M.F.2
-
24
-
-
70349943834
-
STING regulates intracellular DNA-mediated, type i interferon-dependent innate immunity
-
Ishikawa, H., Ma, Z. & Barber, G. N. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461, 788-792 (2009)
-
(2009)
Nature
, vol.461
, pp. 788-792
-
-
Ishikawa, H.1
Ma, Z.2
Barber, G.N.3
-
25
-
-
67651125824
-
A host type i interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
-
McWhirter, S. M. et al. A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. J. Exp. Med. 206, 1899-1911 (2009)
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1899-1911
-
-
McWhirter, S.M.1
-
26
-
-
84929705879
-
Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity
-
Corrales, L. et al. Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 11, 1018-1030 (2015)
-
(2015)
Cell Rep.
, vol.11
, pp. 1018-1030
-
-
Corrales, L.1
-
27
-
-
84950141423
-
STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
-
Demaria, O. et al. STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity. Proc. Natl Acad. Sci. USA 112, 15408-15413 (2015)
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. 15408-15413
-
-
Demaria, O.1
-
28
-
-
84882896267
-
Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
-
Gao, D. et al. Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 341, 903-906 (2013)
-
(2013)
Science
, vol.341
, pp. 903-906
-
-
Gao, D.1
-
29
-
-
84890215093
-
The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells
-
Lahaye, X. et al. The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells. Immunity 39, 1132-1142 (2013)
-
(2013)
Immunity
, vol.39
, pp. 1132-1142
-
-
Lahaye, X.1
-
30
-
-
4344566281
-
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection
-
Hemmi, H. et al. The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J. Exp. Med. 199, 1641-1650 (2004)
-
(2004)
J. Exp. Med.
, vol.199
, pp. 1641-1650
-
-
Hemmi, H.1
-
31
-
-
84930254935
-
Mycobacterium tuberculosis differentially activates cGAS-and inflammasome-dependent intracellular immune responses through ESX-1
-
Wassermann, R. et al. Mycobacterium tuberculosis differentially activates cGAS-and inflammasome-dependent intracellular immune responses through ESX-1. Cell. Host. Microbe 17, 799-810 (2015)
-
(2015)
Cell. Host. Microbe
, vol.17
, pp. 799-810
-
-
Wassermann, R.1
-
32
-
-
84888637695
-
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
-
Ablasser, A. et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature 503, 530-534 (2013)
-
(2013)
Nature
, vol.503
, pp. 530-534
-
-
Ablasser, A.1
-
33
-
-
78449267616
-
Production and titration of lentiviral vectors
-
Barde, I., Salmon, P. & Trono, D. Production and titration of lentiviral vectors. Curr. Protoc. Neurosci. doi: 10.1002/0471142301.ns0421s53 (2010).
-
(2010)
Curr. Protoc. Neurosci.
-
-
Barde, I.1
Salmon, P.2
Trono, D.3
|