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Volumn 8, Issue 1, 2017, Pages

Signalling strength determines proapoptotic functions of STING

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; INTERFERON REGULATORY FACTOR 3; PROTEIN; PROTEIN P53; STING PROTEIN; UNCLASSIFIED DRUG; IRF3 PROTEIN, MOUSE; MEMBRANE PROTEIN; MPYS PROTEIN, MOUSE; PROTEIN BINDING;

EID: 85028938697     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-00573-w     Document Type: Article
Times cited : (335)

References (33)
  • 1
    • 84896958063 scopus 로고    scopus 로고
    • Innate immune sensing and signaling of cytosolic nucleic acids
    • Wu, J. & Chen, Z. J. Innate immune sensing and signaling of cytosolic nucleic acids. Annu. Rev. Immunol. 32, 461-488 (2014)
    • (2014) Annu. Rev. Immunol. , vol.32 , pp. 461-488
    • Wu, J.1    Chen, Z.J.2
  • 2
    • 84873711885 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type i interferon pathway
    • Sun, L., Wu, J., Du, F., Chen, X. & Chen, Z. J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339, 786-791 (2013)
    • (2013) Science , vol.339 , pp. 786-791
    • Sun, L.1    Wu, J.2    Du, F.3    Chen, X.4    Chen, Z.J.5
  • 3
    • 84873724533 scopus 로고    scopus 로고
    • Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
    • Wu, J. et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339, 826-830 (2013)
    • (2013) Science , vol.339 , pp. 826-830
    • Wu, J.1
  • 4
    • 84878309796 scopus 로고    scopus 로고
    • Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
    • Gao, P. et al. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 153, 1094-1107 (2013)
    • (2013) Cell , vol.153 , pp. 1094-1107
    • Gao, P.1
  • 5
    • 84879385334 scopus 로고    scopus 로고
    • CGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING
    • Ablasser, A. et al. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature 498, 380-384 (2013)
    • (2013) Nature , vol.498 , pp. 380-384
    • Ablasser, A.1
  • 6
    • 84878572947 scopus 로고    scopus 로고
    • The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING
    • Diner, E. J. et al. The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Rep. 3, 1355-1361 (2013)
    • (2013) Cell Rep. , vol.3 , pp. 1355-1361
    • Diner, E.J.1
  • 7
    • 84924778328 scopus 로고    scopus 로고
    • Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
    • Liu, S. et al. Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347, aaa2630 (2015)
    • (2015) Science , vol.347 , pp. aaa2630
    • Liu, S.1
  • 8
    • 84912120595 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
    • Woo, S. R. et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 41, 830-842 (2014)
    • (2014) Immunity , vol.41 , pp. 830-842
    • Woo, S.R.1
  • 9
    • 84886789626 scopus 로고    scopus 로고
    • Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling
    • Konno, H., Konno, K. & Barber, G. N. Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 155, 688-698 (2013)
    • (2013) Cell , vol.155 , pp. 688-698
    • Konno, H.1    Konno, K.2    Barber, G.N.3
  • 10
    • 84885332714 scopus 로고    scopus 로고
    • STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease
    • Petrasek, J. et al. STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease. Proc. Natl Acad. Sci. USA 110, 16544-16549 (2013)
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 16544-16549
    • Petrasek, J.1
  • 11
    • 84886027402 scopus 로고    scopus 로고
    • Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis
    • Sze, A. et al. Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis. Cell Host. Microbe. 14, 422-434 (2013)
    • (2013) Cell Host. Microbe. , vol.14 , pp. 422-434
    • Sze, A.1
  • 12
    • 84970963467 scopus 로고    scopus 로고
    • Agonist-mediated activation of STING induces apoptosis in malignant B cells
    • Tang, C. H. et al. Agonist-mediated activation of STING induces apoptosis in malignant B cells. Cancer Res. 76, 2137-2152 (2016)
    • (2016) Cancer Res. , vol.76 , pp. 2137-2152
    • Tang, C.H.1
  • 13
    • 79251506939 scopus 로고    scopus 로고
    • The N-ethyl-N-nitrosourea-induced goldenticket mouse mutant reveals an essential function of sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides
    • Sauer, J. D. et al. The N-ethyl-N-nitrosourea-induced goldenticket mouse mutant reveals an essential function of sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect. Immun. 79, 688-694 (2011)
    • (2011) Infect. Immun. , vol.79 , pp. 688-694
    • Sauer, J.D.1
  • 14
    • 84878638162 scopus 로고    scopus 로고
    • Species-specific detection of the antiviral small-molecule compound CMA by STING
    • Cavlar, T., Deimling, T., Ablasser, A., Hopfner, K. P. & Hornung, V. Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J. 32, 1440-1450 (2013)
    • (2013) EMBO J. , vol.32 , pp. 1440-1450
    • Cavlar, T.1    Deimling, T.2    Ablasser, A.3    Hopfner, K.P.4    Hornung, V.5
  • 15
    • 0038021272 scopus 로고    scopus 로고
    • Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more
    • Marsden, V. S. & Strasser, A. Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu. Rev. Immunol. 21, 71-105 (2003)
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 71-105
    • Marsden, V.S.1    Strasser, A.2
  • 16
    • 84905825645 scopus 로고    scopus 로고
    • Activated STING in a vascular and pulmonary syndrome
    • Liu, Y. et al. Activated STING in a vascular and pulmonary syndrome. N. Engl. J. Med. 371, 507-518 (2014)
    • (2014) N. Engl. J. Med. , vol.371 , pp. 507-518
    • Liu, Y.1
  • 17
    • 84915745085 scopus 로고    scopus 로고
    • Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations
    • Jeremiah, N. et al. Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations. J. Clin. Invest. 124, 5516-5520 (2014)
    • (2014) J. Clin. Invest. , vol.124 , pp. 5516-5520
    • Jeremiah, N.1
  • 18
    • 78649363017 scopus 로고    scopus 로고
    • Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation
    • Wendorff, A. A. et al. Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity 33, 671-684 (2010)
    • (2010) Immunity , vol.33 , pp. 671-684
    • Wendorff, A.A.1
  • 19
    • 80054966913 scopus 로고    scopus 로고
    • STING is a direct innate immune sensor of cyclic di-GMP
    • Burdette, D. L. et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature 478, 515-518 (2011)
    • (2011) Nature , vol.478 , pp. 515-518
    • Burdette, D.L.1
  • 20
    • 84941767986 scopus 로고    scopus 로고
    • Viruses transfer the antiviral second messenger cGAMP between cells
    • Bridgeman, A. et al. Viruses transfer the antiviral second messenger cGAMP between cells. Science 349, 1228-1232 (2015)
    • (2015) Science , vol.349 , pp. 1228-1232
    • Bridgeman, A.1
  • 21
    • 84941785319 scopus 로고    scopus 로고
    • Transmission of innate immune signaling by packaging of cGAMP in viral particles
    • Gentili, M. et al. Transmission of innate immune signaling by packaging of cGAMP in viral particles. Science 349, 1232-1236 (2015)
    • (2015) Science , vol.349 , pp. 1232-1236
    • Gentili, M.1
  • 22
    • 84948670572 scopus 로고    scopus 로고
    • STING: Infection, inflammation and cancer
    • Barber, G. N. STING: infection, inflammation and cancer. Nat. Rev. Immunol. 15, 760-770 (2015)
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 760-770
    • Barber, G.N.1
  • 23
    • 84966263763 scopus 로고    scopus 로고
    • The role of cGAS in innate immunity and beyond
    • Ablasser A. & Gulen M. F. The role of cGAS in innate immunity and beyond. J. Mol. Med. 94, 1085-1093 (2016)
    • (2016) J. Mol. Med. , vol.94 , pp. 1085-1093
    • Ablasser, A.1    Gulen, M.F.2
  • 24
    • 70349943834 scopus 로고    scopus 로고
    • STING regulates intracellular DNA-mediated, type i interferon-dependent innate immunity
    • Ishikawa, H., Ma, Z. & Barber, G. N. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461, 788-792 (2009)
    • (2009) Nature , vol.461 , pp. 788-792
    • Ishikawa, H.1    Ma, Z.2    Barber, G.N.3
  • 25
    • 67651125824 scopus 로고    scopus 로고
    • A host type i interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
    • McWhirter, S. M. et al. A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. J. Exp. Med. 206, 1899-1911 (2009)
    • (2009) J. Exp. Med. , vol.206 , pp. 1899-1911
    • McWhirter, S.M.1
  • 26
    • 84929705879 scopus 로고    scopus 로고
    • Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity
    • Corrales, L. et al. Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 11, 1018-1030 (2015)
    • (2015) Cell Rep. , vol.11 , pp. 1018-1030
    • Corrales, L.1
  • 27
    • 84950141423 scopus 로고    scopus 로고
    • STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
    • Demaria, O. et al. STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity. Proc. Natl Acad. Sci. USA 112, 15408-15413 (2015)
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 15408-15413
    • Demaria, O.1
  • 28
    • 84882896267 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
    • Gao, D. et al. Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 341, 903-906 (2013)
    • (2013) Science , vol.341 , pp. 903-906
    • Gao, D.1
  • 29
    • 84890215093 scopus 로고    scopus 로고
    • The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells
    • Lahaye, X. et al. The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells. Immunity 39, 1132-1142 (2013)
    • (2013) Immunity , vol.39 , pp. 1132-1142
    • Lahaye, X.1
  • 30
    • 4344566281 scopus 로고    scopus 로고
    • The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection
    • Hemmi, H. et al. The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J. Exp. Med. 199, 1641-1650 (2004)
    • (2004) J. Exp. Med. , vol.199 , pp. 1641-1650
    • Hemmi, H.1
  • 31
    • 84930254935 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis differentially activates cGAS-and inflammasome-dependent intracellular immune responses through ESX-1
    • Wassermann, R. et al. Mycobacterium tuberculosis differentially activates cGAS-and inflammasome-dependent intracellular immune responses through ESX-1. Cell. Host. Microbe 17, 799-810 (2015)
    • (2015) Cell. Host. Microbe , vol.17 , pp. 799-810
    • Wassermann, R.1
  • 32
    • 84888637695 scopus 로고    scopus 로고
    • Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
    • Ablasser, A. et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature 503, 530-534 (2013)
    • (2013) Nature , vol.503 , pp. 530-534
    • Ablasser, A.1
  • 33
    • 78449267616 scopus 로고    scopus 로고
    • Production and titration of lentiviral vectors
    • Barde, I., Salmon, P. & Trono, D. Production and titration of lentiviral vectors. Curr. Protoc. Neurosci. doi: 10.1002/0471142301.ns0421s53 (2010).
    • (2010) Curr. Protoc. Neurosci.
    • Barde, I.1    Salmon, P.2    Trono, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.