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Volumn 3, Issue 123, 2010, Pages

Controlling the fate of NIK: A central stage in noncanonical NF-κB signaling

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR FACTOR KAPPA B INDUCING KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

EID: 77953835976     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.3123pe18     Document Type: Review
Times cited : (51)

References (32)
  • 1
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NFkappaB signaling
    • M. S. Hayden, S. Ghosh, Shared principles in NFkappaB signaling. Cell 132, 344-362 (2008).
    • (2008) Cell. , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 2
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappaB transcription factors in the immune system
    • S. Vallabhapurapu, M. Karin, Regulation and function of NF-kappaB transcription factors in the immune system. Annu. Rev. Immunol. 27, 693-733 (2009).
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 3
    • 59449108567 scopus 로고    scopus 로고
    • The roles of the classical and alternative nuclear factorkappaB pathways: Potential implications for autoimmunity and rheumatoid arthritis
    • K. D. Brown, E. Claudio, U. Siebenlist, The roles of the classical and alternative nuclear factorkappaB pathways: Potential implications for autoimmunity and rheumatoid arthritis. Arthritis Res. Ther. 10, 212 (2008).
    • (2008) Arthritis Res. Ther. , vol.10 , pp. 212
    • Brown, K.D.1    Claudio, E.2    Siebenlist, U.3
  • 4
    • 77953859606 scopus 로고    scopus 로고
    • NF-kappaB as a critical link between inflammation and cancer
    • M. Karin, NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb. Perspect. Biol. 1, a000141 (2009).
    • (2009) Cold Spring Harb. Perspect. Biol. , vol.1
    • Karin, M.1
  • 5
    • 70350513270 scopus 로고    scopus 로고
    • Regulation of tissue homeostasis by NF-kappaB signalling: Implications for inflammatory diseases
    • M. Pasparakis, Regulation of tissue homeostasis by NF-kappaB signalling: Implications for inflammatory diseases. Nat. Rev. Immunol. 9, 778-788 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 778-788
    • Pasparakis, M.1
  • 6
    • 52049095036 scopus 로고    scopus 로고
    • New insights into NF-kappaB regulation and function
    • S. C. Sun, S. C. Ley, New insights into NF-kappaB regulation and function. Trends Immunol. 29, 469-478 (2008).
    • (2008) Trends Immunol. , vol.29 , pp. 469-478
    • Sun, S.C.1    Ley, S.C.2
  • 7
    • 77953824286 scopus 로고    scopus 로고
    • Negative feedback in noncanonical NF-κB signaling modulates NIK stability through IKKα-mediated phosphorylation
    • B. Razani, B. Zarnegar, A. J. Ytterberg, T. Shiba, P. W. Dempsey, C. F. Ware, J. A. Loo, G. Cheng, Negative feedback in noncanonical NF-κB signaling modulates NIK stability through IKKα-mediated phosphorylation. Sci. Sig. 3, ra41 (2010).
    • (2010) Sci. Sig , vol.3
    • Razani, B.1    Zarnegar, B.2    Ytterberg, A.J.3    Shiba, T.4    Dempsey, P.W.5    Ware, C.F.6    Loo, J.A.7    Cheng, G.8
  • 8
    • 4544228457 scopus 로고    scopus 로고
    • Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology
    • S. Beinke, S. C. Ley, Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem. J. 382, 393-409 (2004).
    • (2004) Biochem. J. , vol.382 , pp. 393-409
    • Beinke, S.1    Ley, S.C.2
  • 9
    • 33749265867 scopus 로고    scopus 로고
    • The alternative NF-kappaB pathway from biochemistry to biology: Pitfalls and promises for future drug development
    • E. Dejardin, The alternative NF-kappaB pathway from biochemistry to biology: Pitfalls and promises for future drug development. Biochem. Pharmacol. 72, 1161-1179 (2006).
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 1161-1179
    • Dejardin, E.1
  • 10
    • 0034745420 scopus 로고    scopus 로고
    • NF-kappaBinducing kinase regulates the processing of NF-kappaB2 p100
    • G. Xiao, E. W. Harhaj, S. C. Sun, NF-kappaBinducing kinase regulates the processing of NF-kappaB2 p100. Mol. Cell 7, 401-409 (2001).
    • (2001) Mol. Cell. , vol.7 , pp. 401-409
    • Xiao, G.1    Harhaj, E.W.2    Sun, S.C.3
  • 12
    • 0032583947 scopus 로고    scopus 로고
    • NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176
    • L. Ling, Z. Cao, D. V. Goeddel NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Proc. Natl. Acad. Sci. U. S. A. 95, 3792-3797 (1998).
    • (1998) Proc. Natl. Acad. Sci. U. S. A , vol.95 , pp. 3792-3797
    • Ling, L.1    Cao, Z.2    Goeddel, D.V.3
  • 13
    • 3142663912 scopus 로고    scopus 로고
    • Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation
    • G. Xiao, A. Fong, S. C. Sun, Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. J. Biol. Chem. 279, 30099-30105 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 30099-30105
    • Xiao, G.1    Fong, A.2    Sun, S.C.3
  • 14
    • 2942731516 scopus 로고    scopus 로고
    • Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation
    • G. Liao, M. Zhang, E. W. Harhaj, S. C. Sun, Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. J. Biol. Chem. 279, 26243-26250 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 26243-26250
    • Liao, G.1    Zhang, M.2    Harhaj, E.W.3    Sun, S.C.4
  • 15
    • 0036794398 scopus 로고    scopus 로고
    • BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells
    • E. Claudio, K. Brown, S. Park, H. Wang, U. Siebenlist, BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells. Nat. Immunol. 3, 958-965 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 958-965
    • Claudio, E.1    Brown, K.2    Park, S.3    Wang, H.4    Siebenlist, U.5
  • 16
    • 33646336615 scopus 로고    scopus 로고
    • Beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870
    • C. Liang, M. Zhang, S. C. Sun, beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870. Cell. Signal. 18, 1309-1317 (2006).
    • (2006) Cell. Signal , vol.18 , pp. 1309-1317
    • Liang, C.1    Zhang, M.2    Sun, S.C.3
  • 20
    • 56349164232 scopus 로고    scopus 로고
    • Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
    • S. Vallabhapurapu, A. Matsuzawa, W. Zhang, P. H. Tseng, J. J. Keats, H. Wang, D. A. Vignali, P. L. Bergsagel, M. Karin, Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat. Immunol. 9, 1364-1370 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 1364-1370
    • Vallabhapurapu, S.1    Matsuzawa, A.2    Zhang, W.3    Tseng, P.H.4    Keats, J.J.5    Wang, H.6    Vignali, D.A.7    Bergsagel, P.L.8    Karin, M.9
  • 22
    • 34548014506 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs
    • P. Xie, L. L. Stunz, K. D. Larison, B. Yang, G. A. Bishop, Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs. Immunity 27, 253-267 (2007).
    • (2007) Immunity , vol.27 , pp. 253-267
    • Xie, P.1    Stunz, L.L.2    Larison, K.D.3    Yang, B.4    Bishop, G.A.5
  • 23
    • 40249115896 scopus 로고    scopus 로고
    • TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor
    • S. Gardam, F. Sierro, A. Basten, F. Mackay, R. Brink, TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity 28, 391-401 (2008).
    • (2008) Immunity , vol.28 , pp. 391-401
    • Gardam, S.1    Sierro, F.2    Basten, A.3    Mackay, F.4    Brink, R.5
  • 26
    • 0035809310 scopus 로고    scopus 로고
    • Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I
    • A. Matsushima, T. Kaisho, P. D. Rennert, H. Nakano, K. Kurosawa, D. Uchida, K. Takeda, S. Akira, M. Matsumoto, Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I. J. Exp. Med. 193, 631-636 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 631-636
    • Matsushima, A.1    Kaisho, T.2    Rennert, P.D.3    Nakano, H.4    Kurosawa, K.5    Uchida, D.6    Takeda, K.7    Akira, S.8    Matsumoto, M.9
  • 27
    • 0031017618 scopus 로고    scopus 로고
    • MAP3K-related kinase involved in NFkappaB induction by TNF, CD95 and IL-1
    • N. L. Malinin, M. P. Boldin, A. V. Kovalenko, D. Wallach, MAP3K-related kinase involved in NFkappaB induction by TNF, CD95 and IL-1. Nature 385, 540-544 (1997).
    • (1997) Nature , vol.385 , pp. 540-544
    • Malinin, N.L.1    Boldin, M.P.2    Kovalenko, A.V.3    Wallach, D.4
  • 28
    • 42149110830 scopus 로고    scopus 로고
    • Control of canonical NF-kappaB activation through the NIK-IKK complex pathway
    • B. Zarnegar, S. Yamazaki, J. Q. He, G. Cheng, Control of canonical NF-kappaB activation through the NIK-IKK complex pathway. Proc. Natl. Acad. Sci. U. S. A. 105, 3503-3508 (2008).
    • (2008) Proc. Natl. Acad. Sci. U. S. A , vol.105 , pp. 3503-3508
    • Zarnegar, B.1    Yamazaki, S.2    He, J.Q.3    Cheng, G.4
  • 29
    • 17844386319 scopus 로고    scopus 로고
    • IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation
    • T. Lawrence, M. Bebien, G. Y. Liu, V. Nizet, M. Karin, IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature 434, 1138-1143 (2005).
    • (2005) Nature , vol.434 , pp. 1138-1143
    • Lawrence, T.1    Bebien, M.2    Liu, G.Y.3    Nizet, V.4    Karin, M.5
  • 32
    • 77953855525 scopus 로고    scopus 로고
    • Funding: Work performed in the author's laboratory is supported by NIH grants AI064639, AI057555, and GM084459
    • Funding: Work performed in the author's laboratory is supported by NIH grants AI064639, AI057555, and GM084459.


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