CGAS is essential for cellular senescence

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 23, 2017, Pages E4612-E4620

  Yang, Hui ^a   Wang, Hanze ^b   Ren, Unyao ^a   Chen, Qi ^b   Chena, Zhijian J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b FUJIAN NORMAL UNIVERSITY   (China)

Author keywords

Cancer; CGAS; DNA damage; DNA sensing; Senescence

Indexed keywords

CYCLIC GMP ADENOSINE PHOSPHATE SYNTHASE; DNA; ETOPOSIDE; SYNTHETASE; UNCLASSIFIED DRUG; MB21D1 PROTEIN, HUMAN; MB21D1 PROTEIN, MOUSE; NUCLEOTIDYLTRANSFERASE;

ANIMAL CELL; ARTICLE; CANCER PATIENT; CANCER SURVIVAL; CELL AGING; CELL IMMORTALIZATION; CELL NUCLEUS; CELL PROLIFERATION; CHROMATIN; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DNA DAMAGE; EMBRYO; EMBRYO CELL; FIBROBLAST; HUMAN; HUMAN CELL; IONIZING RADIATION; LUNG ADENOCARCINOMA; MITOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; ADENOCARCINOMA; ANIMAL; CELL CULTURE; CYTOLOGY; CYTOSOL; DEFICIENCY; GENE EXPRESSION; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; INNATE IMMUNITY; KNOCKOUT MOUSE; LUNG TUMOR; METABOLISM; MOUSE EMBRYONIC STEM CELL; PHENOTYPE; PHYSIOLOGY; PROGNOSIS;

ADENOCARCINOMA; ANIMALS; CELLS, CULTURED; CELLULAR SENESCENCE; CYTOSOL; DNA DAMAGE; FIBROBLASTS; GENE EXPRESSION; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; LUNG NEOPLASMS; MICE; MICE, KNOCKOUT; MOUSE EMBRYONIC STEM CELLS; NUCLEOTIDYLTRANSFERASES; PHENOTYPE; PROGNOSIS;

EID: 85020284517     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1705499114     Document Type: Article

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