Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma

Clinical Cancer Research

Volumn 17, Issue 24, 2011, Pages 7704-7711

  Bakhoum, Samuel F ^a   Danilova, Olga V ^b   Kaur, Prabhjot ^a,b   Levy, Norman B ^a,b   Compton, Duane A ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANAPHASE; ANEUPLOIDY; ARTICLE; BONE MARROW METASTASIS; CANCER MORTALITY; CANCER PATIENT; CANCER RELAPSE; CANCER STAGING; CANCER SURVIVAL; CHROMOSOMAL INSTABILITY; CHROMOSOME ANALYSIS; CHROMOSOME NUMBER; CHROMOSOME SEGREGATION; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERNATIONAL PROGNOSTIC INDEX SCORE; LARGE CELL LYMPHOMA; LYMPHOMA CELL; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; RECURRENCE FREE SURVIVAL; SCORING SYSTEM; TREATMENT RESPONSE;

AGED; ANAPHASE; ANEUPLOIDY; CHI-SQUARE DISTRIBUTION; CHROMOSOMAL INSTABILITY; CHROMOSOME SEGREGATION; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPHOMA, LARGE B-CELL, DIFFUSE; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PROGNOSIS; PROPORTIONAL HAZARDS MODELS; TIME FACTORS;

EID: 84055176499     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-11-2049     Document Type: Article

References (50)

1. Cimini D. Merotelic kinetochore orientation, aneuploidy, and cancer. Biochim Biophys Acta 2008;1786:32-40.
2. Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature 1997;386:623-7. (Pubitemid 27175430)
3. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998;396:643-9. (Pubitemid 29003936)
4. Chung DC, Pino MS. The chromosomal instability pathway in colon cancer. Gastroenterology 2010;138:2059-72.
5. Lingle WL, Lukasiewicz K, Salisbury JL. Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer. Adv Exp Med Biol 2005;570:393-421. (Pubitemid 47413181)
6. Walther A, Houlston R, Tomlinson I. Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis. Gut 2008;57:941-50. (Pubitemid 351919529)
7. M'kacher R, Andreoletti L, Flamant S, Milliat F, Girinsky T, Dossou J, et al. JC human polyomavirus is associated to chromosomal instability in peripheral blood lymphocytes of Hodgkin's lymphoma patients and poor clinical outcome. Ann Oncol 2010;21:826-32.
8. Knudson CM, van de Wetering CI. Chromosomal instability and supernumerary centrosomes represent precursor defects in a mouse model of T-cell lymphoma. Cancer Res 2007;67:8081-8. (Pubitemid 47395142)
9. Kramer A, Schweizer S, Neben K, Giesecke C, Kalla J, Katzenberger T, et al. Centrosome aberrations as a possible mechanism for chromosomal instability in non-Hodgkin's lymphoma. Leukemia 2003;17:2207-13. (Pubitemid 37428388)
10. Swanton C, Tomlinson I, Downward J. Chromosomal instability, colorectal cancer and taxane resistance. Cell Cycle 2006;5:818-23. (Pubitemid 44145573)
11. Thompson SL, Compton DA. Examining the link between chromosomal instability and aneuploidy in human cells. JCell Biol 2008;180:665-72. (Pubitemid 351397764)
12. Paulsson K, Johansson B. Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes. Pathol Biol 2007;55:37-48. (Pubitemid 46217945)
13. Mugneret F, Callier P, Favre-Audry B. Chromosomal abnormalities in acute myeloid leukaemias. Pathol Biol 2003;51:314-28. (Pubitemid 37064645)
14. Gulley ML, Shea TC, Fedoriw Y. Genetic tests to evaluate prognosis and predict therapeutic response in acute myeloid leukemia. J Mol Diagn 2010;12:3-16.
15. Kobayashi K, Usami I, Kubota M, Nishio T, Kakazu N. Chromosome 7 abnormalities in acute megakaryoblastic leukemia associated with Down syndrome. Cancer Genet Cytogenet 2005;158:184-7. (Pubitemid 40417702)
16. Jacquemont S, Boceno M, Rival JM, Mechinaud F, David A. High risk of malignancy in mosaic variegated aneuploidy syndrome. Am J Med Genet 2002;109:17-21. (Pubitemid 34259949)
17. Rahman N, Hanks S, Coleman K, Reid S, Plaja A, Firth H, et al. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet 2004;36:1159-61. (Pubitemid 41288963)
18. Szallasi Z, Carter SL, Eklund AC, Kohane IS, Harris LN. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat Genet 2006;38:1043-8. (Pubitemid 44325930)
19. Weaver BA, Silk AD, Montagna C, Verdier-Pinard P, Cleveland DW. Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 2007;11:25-36. (Pubitemid 46070223)
20. Benezra R, Sotillo R, Schvartzman JM, Socci ND. Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature 2010;464:436-40.
21. Benezra R, Schvartzman JM, Sotillo R. Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nat Rev Cancer 2010;10:102-15.
22. van Deursen JM, Baker DJ, Jin F, Jeganathan KB. Whole chromosome instability caused by bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell 2009;16:475-86.
23. Birkbak NJ, Eklund AC, Li Q, McClelland SE, Endesfelder D, Tan P, et al. Paradoxical relationship between chromosomal instability and survival outcome in cancer. Cancer Res 2011;71:3447-52.
24. Roylance R, Endesfelder D, Gorman P, Burrell RA, Sander J, Tomlinson I, et al. Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer. Cancer Epidemiol Biomarkers Prev 2011;20:2183-94.
25. Lee AJX, Endesfelder D, Rowan AJ, Walther A, Birkbak NJ, Futreal PA, et al. Chromosomal instability confers intrinsic multidrug resistance. Cancer Res 2011;71:1858-70.
26. Martens JWM, Smid M, Hoes M, Sieuwerts AM, Sleijfer S, Zhang Y, et al. Patterns and incidence of chromosomal instability and their prognostic relevance in breast cancer subtypes. Breast Cancer Res Treat 2011;128:23-30.
27. Benezra R, Schvartzman JM, Duijf PHG, Sotillo R, Coker C. Mad2 is a critical mediator of the chromosome instability observed upon rb and p53 pathway inhibition. Cancer Cell 2011;19:701-14.
28. Thompson SL, Bakhoum SF, Compton DA. Mechanisms of chromosomal instability. Curr Biol 2010;20:R285-95.
29. Pati D, Zhang NG, Ge GQ, Meyer R, Sethi S, Basu D, et al. Overexpression of Separase induces aneuploidy and mammary tumorigenesis. Proc Natl Acad Sci U S A 2008;105:13033-8.
30. Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD, et al. Mutations of mitotic checkpoint genes in human cancers. Nature 1998;392:300-3. (Pubitemid 28155105)
31. Di Leonardo A, Lentini L, Amato A, Schillaci T. Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype. BMC Cancer 2007;7:212.
32. Silkworth WT, Nardi IK, Scholl LM, Cimini D. Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PLoS One 2009;8:e6564.
33. Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature 2009:460:278-82 doi:10.1038/nature08136.
34. Tusell L, Pampalona J, Soler D, Frias C, Genesca A. Different outcomes of telomere-dependent anaphase bridges. Biochem Soc Trans 2010;38:1698-703.
35. Bakhoum SF, Thompson SL, Manning AL, Compton DA. Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. Nat Cell Biol 2009;11:27-35.
36. Bakhoum SF, Genovese G, Compton DA. Deviant kinetochore microtubule dynamics underlie chromosomal instability. Curr Biol 2009;19:1937-42.
37. Cheung ALM, Deng W. Telomere dysfunction, genome instability and cancer. Front Biosci 2008;13:2075-90. (Pubitemid 351589236)
38. Cimini D, Howell B, Maddox P, Khodjakov A, Degrassi F, Salmon ED. Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J Cell Biol 2001;153:517-27. (Pubitemid 34280139)
39. Cimini D, Howell BJ, Degrassi F, Salmon ED. Merotelic attachment of single kinetochores to microtubules from opposite poles is not detected by the mitotic spindle checkpoint and induces chromosome loss during mitosis. Mol Biol Cell 2000;11:430a-a.
40. Tornillo L, Bernasconi B, Karamitopolou-Diamantiis E, Lugli A, Vizio D, Dirnhofer S, et al. Chromosomal instability in gastric mucosa-associated lymphoid tissue lymphomas: a fluorescent in situ hybridization study using a tissue microarray approach. Hum Pathol 2008;39:536-42.
41. Tibiletti MG, Milani K, Martin V, Zucca E, Motta T, Cortelazzo S, et al. Chromosome instability and translocation t(11;18) in primary gastric marginal zone B-cell lymphoma of MALT-type. Hematol Oncol 2007;25:184-8.
42. Tzankov A, Gschwendtner A, Augustin F, Fiegl M, Obermann EC, Dirnhofer S, et al. Diffuse large B-cell lymphoma with overexpression of cyclin E substantiates poor standard treatment response and inferior outcome. Clin Cancer Res 2006;12:2125-32.
43. A predictive model for aggressive non-Hodgkin's lymphoma. The International Non-Hodgkin's Lymphoma Prognostic Factors Project. N Engl J Med 1993;329:987-94.
44. Komarova NL, Wodarz D. The optimal rate of chromosome loss for the inactivation of tumor suppressor genes in cancer. Proc Natl Acad Sci U S A 2004;101:7017-21. (Pubitemid 38596435)
45. Woude GFV, Gao CF, Furge K, Koeman J, Dykema K, Su YL, et al. Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations. Proc Natl Acad Sci U S A 2007;104:8995-9000. (Pubitemid 47175425)
46. Kops GJPL, Janssen A, Medema RH. Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. Proc Natl Acad Sci U S A 2009;106:19108-13.
47. Wang Z, Cummins JM, Shen D, Cahill DP, Jallepalli PV, Wang TL, et al. Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Res 2004;64:2998-3001. (Pubitemid 38581395)
48. Marcon F, Palli D, Zufferli A, Mazzoli E, Siniscalchi E, Sera F, et al. Evaluation of radiation-induced chromosome instability in subjects with a family history of gastric cancer. Biomarkers 2009;14:226-34.
49. Schellens JH, Boss DS, Witteveen PO, van der Sar J, Lolkema MP, Voest EE, et al. Clinical evaluation of AZD1152, an i.v. inhibitor of Aurora B kinase, in patients with solid malignant tumors. Ann Oncol 2011;22:431-7.
50. Manning AL, Bakhoum SF, Maffini S, Correia-Melo C, Maiato H, Compton DA. CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity. EMBO J 2010;29:3531-43.