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Volumn 548, Issue 7668, 2017, Pages 461-465

CGAS surveillance of micronuclei links genome instability to innate immunity

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MB21D1 PROTEIN, HUMAN; MB21D1 PROTEIN, MOUSE; NUCLEOTIDYLTRANSFERASE; TRANSCRIPTOME;

EID: 85028315246     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature23449     Document Type: Article
Times cited : (1178)

References (55)
  • 1
    • 84964342391 scopus 로고    scopus 로고
    • Recognition of endogenous nucleic acids by the innate immune system
    • Roers, A., Hiller, B. & Hornung, V. Recognition of endogenous nucleic acids by the innate immune system. Immunity 44, 739-754 (2016).
    • (2016) Immunity , vol.44 , pp. 739-754
    • Roers, A.1    Hiller, B.2    Hornung, V.3
  • 2
    • 84910031744 scopus 로고    scopus 로고
    • Inflammation-driven carcinogenesis is mediated through STING
    • Ahn, J. et al. Inflammation-driven carcinogenesis is mediated through STING. Nat. Commun. 5, 5166 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 5166
    • Ahn, J.1
  • 3
    • 84947245185 scopus 로고    scopus 로고
    • Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
    • Gao, D. et al. Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases. Proc. Natl Acad. Sci. USA 112, E5699-E5705 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. E5699-E5705
    • Gao, D.1
  • 4
    • 84922986861 scopus 로고    scopus 로고
    • DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity
    • Härtlova, A. et al. DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity. Immunity 42, 332-343 (2015).
    • (2015) Immunity , vol.42 , pp. 332-343
    • Härtlova, A.1
  • 5
    • 84959450304 scopus 로고    scopus 로고
    • Ribonuclease H2 mutations induce a cGAS/STINGdependent innate immune response
    • Mackenzie, K. J. et al. Ribonuclease H2 mutations induce a cGAS/STINGdependent innate immune response. EMBO J. 35, 831-844 (2016).
    • (2016) EMBO J. , vol.35 , pp. 831-844
    • Mackenzie, K.J.1
  • 6
    • 84961214693 scopus 로고    scopus 로고
    • RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice
    • Pokatayev, V. et al. RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice. J. Exp. Med. 213, 329-336 (2016).
    • (2016) J. Exp. Med. , vol.213 , pp. 329-336
    • Pokatayev, V.1
  • 7
    • 84930941966 scopus 로고    scopus 로고
    • Chromothripsis from DNA damage in micronuclei
    • Zhang, C. Z. et al. Chromothripsis from DNA damage in micronuclei. Nature 522, 179-184 (2015).
    • (2015) Nature , vol.522 , pp. 179-184
    • Zhang, C.Z.1
  • 8
    • 84933514711 scopus 로고    scopus 로고
    • Activation and regulation of DNA-driven immune responses
    • Paludan, S. R. Activation and regulation of DNA-driven immune responses. Microbiol. Mol. Biol. Rev. 79, 225-241 (2015).
    • (2015) Microbiol. Mol. Biol. Rev. , vol.79 , pp. 225-241
    • Paludan, S.R.1
  • 9
    • 84878309796 scopus 로고    scopus 로고
    • Cyclic [G(2',5' )pA(3',5' )p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
    • Gao, P. et al. Cyclic [G(2',5' )pA(3',5' )p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 153, 1094-1107 (2013).
    • (2013) Cell , vol.153 , pp. 1094-1107
    • Gao, P.1
  • 10
    • 84873711885 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
    • Sun, L., Wu, J., Du, F., Chen, X. & Chen, Z. J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339, 786-791 (2013).
    • (2013) Science , vol.339 , pp. 786-791
    • Sun, L.1    Wu, J.2    Du, F.3    Chen, X.4    Chen, Z.J.5
  • 11
    • 84879385334 scopus 로고    scopus 로고
    • CGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING
    • Ablasser, A. et al. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature 498, 380-384 (2013).
    • (2013) Nature , vol.498 , pp. 380-384
    • Ablasser, A.1
  • 12
    • 84964698449 scopus 로고    scopus 로고
    • STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment
    • Ohkuri, T. et al. STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment. Cancer Immunol. Res. 2, 1199-1208 (2014).
    • (2014) Cancer Immunol. Res. , vol.2 , pp. 1199-1208
    • Ohkuri, T.1
  • 13
    • 84928205707 scopus 로고    scopus 로고
    • Genome-derived cytosolic DNA mediates type I interferondependent rejection of B cell lymphoma cells
    • Shen, Y. J. et al. Genome-derived cytosolic DNA mediates type I interferondependent rejection of B cell lymphoma cells. Cell Reports 11, 460-473 (2015).
    • (2015) Cell Reports , vol.11 , pp. 460-473
    • Shen, Y.J.1
  • 14
    • 84948670572 scopus 로고    scopus 로고
    • STING: Infection, inflammation and cancer
    • Barber, G. N. STING: infection, inflammation and cancer. Nat. Rev. Immunol. 15, 760-770 (2015).
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 760-770
    • Barber, G.N.1
  • 15
    • 84988566040 scopus 로고    scopus 로고
    • Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing
    • Chen, Q., Sun, L. & Chen, Z. J. Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing. Nat. Immunol. 17, 1142-1149 (2016).
    • (2016) Nat. Immunol. , vol.17 , pp. 1142-1149
    • Chen, Q.1    Sun, L.2    Chen, Z.J.3
  • 16
    • 84861578543 scopus 로고    scopus 로고
    • Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development
    • Reijns, M. A. et al. Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. Cell 149, 1008-1022 (2012).
    • (2012) Cell , vol.149 , pp. 1008-1022
    • Reijns, M.A.1
  • 17
    • 84856424908 scopus 로고    scopus 로고
    • DNA breaks and chromosome pulverization from errors in mitosis
    • Crasta, K. et al. DNA breaks and chromosome pulverization from errors in mitosis. Nature 482, 53-58 (2012).
    • (2012) Nature , vol.482 , pp. 53-58
    • Crasta, K.1
  • 18
    • 84879956366 scopus 로고    scopus 로고
    • Catastrophic nuclear envelope collapse in cancer cell micronuclei
    • Hatch, E. M., Fischer, A. H., Deerinck, T. J. & Hetzer, M. W. Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell 154, 47-60 (2013).
    • (2013) Cell , vol.154 , pp. 47-60
    • Hatch, E.M.1    Fischer, A.H.2    Deerinck, T.J.3    Hetzer, M.W.4
  • 19
    • 84893863593 scopus 로고    scopus 로고
    • The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop
    • Zhang, X. et al. The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop. Cell Reports 6, 421-430 (2014).
    • (2014) Cell Reports , vol.6 , pp. 421-430
    • Zhang, X.1
  • 20
    • 84890235012 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization
    • Li, X. et al. Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization. Immunity 39, 1019-1031 (2013).
    • (2013) Immunity , vol.39 , pp. 1019-1031
    • Li, X.1
  • 21
    • 84907996785 scopus 로고    scopus 로고
    • Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy
    • Lan, Y. Y., Londoño, D., Bouley, R., Rooney, M. S. & Hacohen, N. Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy. Cell Reports 9, 180-192 (2014).
    • (2014) Cell Reports , vol.9 , pp. 180-192
    • Lan, Y.Y.1    Londoño, D.2    Bouley, R.3    Rooney, M.S.4    Hacohen, N.5
  • 22
    • 84961613728 scopus 로고    scopus 로고
    • Nuclear envelope rupture and repair during cancer cell migration
    • Denais, C. M. et al. Nuclear envelope rupture and repair during cancer cell migration. Science 352, 353-358 (2016).
    • (2016) Science , vol.352 , pp. 353-358
    • Denais, C.M.1
  • 23
    • 84963538020 scopus 로고    scopus 로고
    • ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death
    • Raab, M. et al. ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death. Science 352, 359-362 (2016).
    • (2016) Science , vol.352 , pp. 359-362
    • Raab, M.1
  • 24
    • 84899567326 scopus 로고    scopus 로고
    • Breaching the nuclear envelope in development and disease
    • Hatch, E. & Hetzer, M. Breaching the nuclear envelope in development and disease. J. Cell Biol. 205, 133-141 (2014).
    • (2014) J. Cell Biol. , vol.205 , pp. 133-141
    • Hatch, E.1    Hetzer, M.2
  • 25
    • 84950240143 scopus 로고    scopus 로고
    • Chromothripsis and kataegis induced by telomere crisis
    • Maciejowski, J., Li, Y., Bosco, N., Campbell, P. J. & de Lange, T. Chromothripsis and kataegis induced by telomere crisis. Cell 163, 1641-1654 (2015).
    • (2015) Cell , vol.163 , pp. 1641-1654
    • Maciejowski, J.1    Li, Y.2    Bosco, N.3    Campbell, P.J.4    De Lange, T.5
  • 26
    • 0035144955 scopus 로고    scopus 로고
    • Abnormal nuclear shape in solid tumors reflects mitotic instability
    • Gisselsson, D. et al. Abnormal nuclear shape in solid tumors reflects mitotic instability. Am. J. Pathol. 158, 199-206 (2001).
    • (2001) Am. J. Pathol. , vol.158 , pp. 199-206
    • Gisselsson, D.1
  • 27
    • 39449096135 scopus 로고    scopus 로고
    • Genome instability: A mechanistic view of its causes and consequences
    • Aguilera, A. & Gómez-González, B. Genome instability: a mechanistic view of its causes and consequences. Nat. Rev. Genet. 9, 204-217 (2008).
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 204-217
    • Aguilera, A.1    Gómez-González, B.2
  • 28
    • 84859726409 scopus 로고    scopus 로고
    • Chromosomal instability and cancer: A complex relationship with therapeutic potential
    • Bakhoum, S. F. & Compton, D. A. Chromosomal instability and cancer: a complex relationship with therapeutic potential. J. Clin. Invest. 122, 1138-1143 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 1138-1143
    • Bakhoum, S.F.1    Compton, D.A.2
  • 29
    • 84966263763 scopus 로고    scopus 로고
    • The role of cGAS in innate immunity and beyond
    • Ablasser, A. & Gulen, M. F. The role of cGAS in innate immunity and beyond. J. Mol. Med. (Berl.) 94, 1085-1093 (2016).
    • (2016) J. Mol. Med. (Berl.) , vol.94 , pp. 1085-1093
    • Ablasser, A.1    Gulen, M.F.2
  • 30
    • 84912120595 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
    • Woo, S. R. et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 41, 830-842 (2014).
    • (2014) Immunity , vol.41 , pp. 830-842
    • Woo, S.R.1
  • 31
    • 84955365022 scopus 로고    scopus 로고
    • Deregulation of STING signaling in colorectal carcinoma constrains DNA damage responses and correlates with tumorigenesis
    • Xia, T., Konno, H., Ahn, J. & Barber, G. N. Deregulation of STING signaling in colorectal carcinoma constrains DNA damage responses and correlates with tumorigenesis. Cell Reports 14, 282-297 (2016).
    • (2016) Cell Reports , vol.14 , pp. 282-297
    • Xia, T.1    Konno, H.2    Ahn, J.3    Barber, G.N.4
  • 32
    • 84945353895 scopus 로고    scopus 로고
    • DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway
    • Lau, L., Gray, E. E., Brunette, R. L. & Stetson, D. B. DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway. Science 350, 568-571 (2015).
    • (2015) Science , vol.350 , pp. 568-571
    • Lau, L.1    Gray, E.E.2    Brunette, R.L.3    Stetson, D.B.4
  • 33
    • 0028118111 scopus 로고
    • Tumor spectrum analysis in p53-mutant mice
    • Jacks, T. et al. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4, 1-7 (1994).
    • (1994) Curr. Biol. , vol.4 , pp. 1-7
    • Jacks, T.1
  • 34
    • 84941767986 scopus 로고    scopus 로고
    • Viruses transfer the antiviral second messenger cGAMP between cells
    • Bridgeman, A. et al. Viruses transfer the antiviral second messenger cGAMP between cells. Science 349, 1228-1232 (2015).
    • (2015) Science , vol.349 , pp. 1228-1232
    • Bridgeman, A.1
  • 36
    • 84856326484 scopus 로고    scopus 로고
    • Analysis of the cellular uptake and nuclear delivery of insulin-like growth factor binding protein-3 in human osteosarcoma cells
    • Micutkova, L. et al. Analysis of the cellular uptake and nuclear delivery of insulin-like growth factor binding protein-3 in human osteosarcoma cells. Int. J. Cancer 130, 1544-1557 (2012).
    • (2012) Int. J. Cancer , vol.130 , pp. 1544-1557
    • Micutkova, L.1
  • 37
    • 84925954053 scopus 로고    scopus 로고
    • A high-throughput in vivo micronucleus assay for genome instability screening in mice
    • Balmus, G. et al. A high-throughput in vivo micronucleus assay for genome instability screening in mice. Nat. Protoc. 10, 205-215 (2015).
    • (2015) Nat. Protoc. , vol.10 , pp. 205-215
    • Balmus, G.1
  • 38
    • 4444258534 scopus 로고    scopus 로고
    • Chromatin architecture of the human genome: Gene-rich domains are enriched in open chromatin fibers
    • Gilbert, N. et al. Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers. Cell 118, 555-566 (2004).
    • (2004) Cell , vol.118 , pp. 555-566
    • Gilbert, N.1
  • 39
    • 78149433663 scopus 로고    scopus 로고
    • Analysis of active and inactive X chromosome architecture reveals the independent organization of 30 nm and large-scale chromatin structures
    • Naughton, C., Sproul, D., Hamilton, C. & Gilbert, N. Analysis of active and inactive X chromosome architecture reveals the independent organization of 30 nm and large-scale chromatin structures. Mol. Cell 40, 397-409 (2010).
    • (2010) Mol. Cell , vol.40 , pp. 397-409
    • Naughton, C.1    Sproul, D.2    Hamilton, C.3    Gilbert, N.4
  • 40
    • 34248223080 scopus 로고    scopus 로고
    • DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compaction
    • Gilbert, N. et al. DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compaction. J. Cell Biol. 177, 401-411 (2007).
    • (2007) J. Cell Biol. , vol.177 , pp. 401-411
    • Gilbert, N.1
  • 41
    • 11844299709 scopus 로고    scopus 로고
    • A method for the in vitro reconstitution of a defined "30 nm" chromatin fibre containing stoichiometric amounts of the linker histone
    • Huynh, V. A., Robinson, P. J. & Rhodes, D. A method for the in vitro reconstitution of a defined "30 nm" chromatin fibre containing stoichiometric amounts of the linker histone. J. Mol. Biol. 345, 957-968 (2005).
    • (2005) J. Mol. Biol. , vol.345 , pp. 957-968
    • Huynh, V.A.1    Robinson, P.J.2    Rhodes, D.3
  • 42
    • 85052429870 scopus 로고    scopus 로고
    • Assembly of nucleosomal arrays from recombinant core histones and nucleosome positioning DNA
    • Rogge, R. A. et al. Assembly of nucleosomal arrays from recombinant core histones and nucleosome positioning DNA. J. Vis. Exp. 79, 50354 (2013).
    • (2013) J. Vis. Exp. , vol.79 , pp. 50354
    • Rogge, R.A.1
  • 43
    • 84891677425 scopus 로고    scopus 로고
    • Full-length RNA-seq from single cells using Smart-seq2
    • Picelli, S. et al. Full-length RNA-seq from single cells using Smart-seq2. Nat. Protoc. 9, 171-181 (2014).
    • (2014) Nat. Protoc. , vol.9 , pp. 171-181
    • Picelli, S.1
  • 44
    • 85019709160 scopus 로고    scopus 로고
    • Proliferation drives aging-related functional decline in a subpopulation of the hematopoietic stem cell compartment
    • Kirschner, K. et al. Proliferation drives aging-related functional decline in a subpopulation of the hematopoietic stem cell compartment. Cell Reports 19, 1503-1511 (2017).
    • (2017) Cell Reports , vol.19 , pp. 1503-1511
    • Kirschner, K.1
  • 45
    • 27144548491 scopus 로고    scopus 로고
    • The External RNA Controls Consortium: A progress report
    • Baker, S. C. et al. The External RNA Controls Consortium: a progress report. Nat. Methods 2, 731-734 (2005).
    • (2005) Nat. Methods , vol.2 , pp. 731-734
    • Baker, S.C.1
  • 46
    • 84871809302 scopus 로고    scopus 로고
    • STAR: Ultrafast universal RNA-seq aligner
    • Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15-21 (2013).
    • (2013) Bioinformatics , vol.29 , pp. 15-21
    • Dobin, A.1
  • 47
    • 84878580738 scopus 로고    scopus 로고
    • The Subread aligner: Fast, accurate and scalable read mapping by seed-and-vote
    • Liao, Y., Smyth, G. K. & Shi, W. The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote. Nucleic Acids Res. 41, e108 (2013).
    • (2013) Nucleic Acids Res. , vol.41 , pp. e108
    • Liao, Y.1    Smyth, G.K.2    Shi, W.3
  • 48
    • 85019072518 scopus 로고    scopus 로고
    • Scater: Pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R
    • McCarthy, D. J., Campbell, K. R., Lun, A. T. & Wills, Q. F. Scater: pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R. Bioinformatics 33, 1179-1186 (2017).
    • (2017) Bioinformatics , vol.33 , pp. 1179-1186
    • McCarthy, D.J.1    Campbell, K.R.2    Lun, A.T.3    Wills, Q.F.4
  • 49
    • 84903574951 scopus 로고    scopus 로고
    • Bayesian approach to single-cell differential expression analysis
    • Kharchenko, P. V., Silberstein, L. & Scadden, D. T. Bayesian approach to single-cell differential expression analysis. Nat. Methods 11, 740-742 (2014).
    • (2014) Nat. Methods , vol.11 , pp. 740-742
    • Kharchenko, P.V.1    Silberstein, L.2    Scadden, D.T.3
  • 50
    • 84928586627 scopus 로고    scopus 로고
    • Central role of ULK1 in type I interferon signaling
    • Saleiro, D. et al. Central role of ULK1 in type I interferon signaling. Cell Reports 11, 605-617 (2015).
    • (2015) Cell Reports , vol.11 , pp. 605-617
    • Saleiro, D.1
  • 51
    • 0037314097 scopus 로고    scopus 로고
    • Matrix2png: A utility for visualizing matrix data
    • Pavlidis, P. & Noble, W. S. Matrix2png: a utility for visualizing matrix data. Bioinformatics 19, 295-296 (2003).
    • (2003) Bioinformatics , vol.19 , pp. 295-296
    • Pavlidis, P.1    Noble, W.S.2
  • 52
    • 84895904323 scopus 로고    scopus 로고
    • Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
    • Schoggins, J. W. et al. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature 505, 691-695 (2014).
    • (2014) Nature , vol.505 , pp. 691-695
    • Schoggins, J.W.1
  • 53
    • 0036166206 scopus 로고    scopus 로고
    • When repair meets chromatin. First in series on chromatin dynamics
    • Green, C. M. & Almouzni, G. When repair meets chromatin. First in series on chromatin dynamics. EMBO Rep. 3, 28-33 (2002).
    • (2002) EMBO Rep. , vol.3 , pp. 28-33
    • Green, C.M.1    Almouzni, G.2
  • 54
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: Making it safe to play with knives
    • Ciccia, A. & Elledge, S. J. The DNA damage response: making it safe to play with knives. Mol. Cell 40, 179-204 (2010).
    • (2010) Mol. Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 55
    • 67349212889 scopus 로고    scopus 로고
    • Coordination of dual incision and repair synthesis in human nucleotide excision repair
    • Staresincic, L. et al. Coordination of dual incision and repair synthesis in human nucleotide excision repair. EMBO J. 28, 1111-1120 (2009).
    • (2009) EMBO J. , vol.28 , pp. 1111-1120
    • Staresincic, L.1


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