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Volumn 19, Issue 1, 2018, Pages 10-19

Erratum to: The twilight of immunity: emerging concepts in aging of the immune system (Nature Immunology, (2018), 19, 1, (10-19), 10.1038/s41590-017-0006-x);The twilight of immunity: Emerging concepts in aging of the immune system review-article

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GROWTH FACTOR; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 85038866013     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/s41590-018-0205-0     Document Type: Erratum
Times cited : (719)

References (114)
  • 2
    • 2142644403 scopus 로고    scopus 로고
    • Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo
    • Haynes, L., Eaton, S. M., Burns, E. M., Rincon, M. and Swain, S. L. Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo. J. Immunol. 172, 5194-5199 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 5194-5199
    • Haynes, L.1    Eaton, S.M.2    Burns, E.M.3    Rincon, M.4    Swain, S.L.5
  • 3
    • 38649132010 scopus 로고    scopus 로고
    • CpG-ODN but not other TLR-ligands restore the antitumor responses in old mice: The implications for vaccinations in the aged
    • Sharma, S., Dominguez, A. L., Hoelzinger, D. B. and Lustgarten, J. CpG-ODN but not other TLR-ligands restore the antitumor responses in old mice: the implications for vaccinations in the aged. Cancer Immunol. Immunother. 57, 549-561 (2008).
    • (2008) Cancer Immunol. Immunother. , vol.57 , pp. 549-561
    • Sharma, S.1    Dominguez, A.L.2    Hoelzinger, D.B.3    Lustgarten, J.4
  • 4
    • 84929850029 scopus 로고    scopus 로고
    • Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults
    • Lal, H. et al. Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N. Engl. J. Med. 372, 2087-2096 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 2087-2096
    • Lal, H.1
  • 5
    • 84921634186 scopus 로고    scopus 로고
    • Aging of the T cell compartment in mice and humans: From no naive expectations to foggy memories
    • Nikolich-Zugich, J. Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories. J. Immunol. 193, 2622-2629 (2014).
    • (2014) J. Immunol. , vol.193 , pp. 2622-2629
    • Nikolich-Zugich, J.1
  • 6
    • 84939881933 scopus 로고    scopus 로고
    • Innate immunesenescence: Underlying mechanisms and clinical relevance
    • Hazeldine, J. and Lord, J. M. Innate immunesenescence: underlying mechanisms and clinical relevance. Biogerontology 16, 187-201 (2015).
    • (2015) Biogerontology , vol.16 , pp. 187-201
    • Hazeldine, J.1    Lord, J.M.2
  • 7
    • 84948972267 scopus 로고    scopus 로고
    • Paradoxical changes in innate immunity in aging: Recent progress and new directions
    • Montgomery, R. R. and Shaw, A. C. Paradoxical changes in innate immunity in aging: recent progress and new directions. J. Leukoc. Biol. 98, 937-943 (2015).
    • (2015) J. Leukoc. Biol. , vol.98 , pp. 937-943
    • Montgomery, R.R.1    Shaw, A.C.2
  • 8
    • 84984698714 scopus 로고    scopus 로고
    • Glimpse of natural selection of long-lived T-cell clones in healthy life
    • Zhang, B. et al. Glimpse of natural selection of long-lived T-cell clones in healthy life. Proc. Natl. Acad. Sci. USA 113, 9858-9863 (2016).
    • (2016) Proc. Natl. Acad. Sci. USA , vol.113 , pp. 9858-9863
    • Zhang, B.1
  • 11
    • 84868193217 scopus 로고    scopus 로고
    • Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans
    • Solana, R. et al. Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. Semin. Immunol. 24, 331-341 (2012).
    • (2012) Semin. Immunol. , vol.24 , pp. 331-341
    • Solana, R.1
  • 12
    • 79951722208 scopus 로고    scopus 로고
    • Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis
    • Simell, B. et al. Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis. Vaccine 29, 1929-1934 (2011).
    • (2011) Vaccine , vol.29 , pp. 1929-1934
    • Simell, B.1
  • 13
    • 84864378864 scopus 로고    scopus 로고
    • Innate immune dysfunctions in aged mice facilitate the systemic dissemination of methicillin-resistant S.aureus
    • Tseng, C. W. et al. Innate immune dysfunctions in aged mice facilitate the systemic dissemination of methicillin-resistant S. aureus. PLoS One 7, e41454 (2012).
    • (2012) PLoS One , vol.7 , pp. e41454
    • Tseng, C.W.1
  • 14
    • 33846208784 scopus 로고    scopus 로고
    • Age-associated defect in human TLR-1/2 function
    • van Duin, D. et al. Age-associated defect in human TLR-1/2 function. J. Immunol. 178, 970-975 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 970-975
    • Van Duin, D.1
  • 15
    • 84939516469 scopus 로고    scopus 로고
    • Age-related changes in natural killer cell repertoires: Impact on NK cell function and immune surveillance
    • Manser, A. R. and Uhrberg, M. Age-related changes in natural killer cell repertoires: impact on NK cell function and immune surveillance. Cancer Immunol. Immunother. 65, 417-426 (2016).
    • (2016) Cancer Immunol. Immunother. , vol.65 , pp. 417-426
    • Manser, A.R.1    Uhrberg, M.2
  • 16
    • 78149319109 scopus 로고    scopus 로고
    • Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking
    • Fang, M., Roscoe, F. and Sigal, L. J. Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking. J. Exp. Med. 207, 2369-2381 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 2369-2381
    • Fang, M.1    Roscoe, F.2    Sigal, L.J.3
  • 17
    • 43349104959 scopus 로고    scopus 로고
    • Ageing is associated with diminished apoptotic cell clearance in vivo
    • Aprahamian, T., Takemura, Y., Goukassian, D. and Walsh, K. Ageing is associated with diminished apoptotic cell clearance in vivo. Clin. Exp. Immunol. 152, 448-455 (2008).
    • (2008) Clin. Exp. Immunol. , vol.152 , pp. 448-455
    • Aprahamian, T.1    Takemura, Y.2    Goukassian, D.3    Walsh, K.4
  • 18
    • 84927711067 scopus 로고    scopus 로고
    • Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors
    • Metcalf, T. U. et al. Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors. Aging Cell 14, 421-432 (2015).
    • (2015) Aging Cell , vol.14 , pp. 421-432
    • Metcalf, T.U.1
  • 19
    • 85027359896 scopus 로고    scopus 로고
    • Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists
    • Metcalf, T. U. et al. Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists. J. Immunol. 199, 1405-1417 (2017).
    • (2017) J. Immunol. , vol.199 , pp. 1405-1417
    • Metcalf, T.U.1
  • 20
    • 0036231373 scopus 로고    scopus 로고
    • Influence of ageing on Langerhans cell migration in mice: Identification of a putative deficiency of epidermal interleukin-1beta
    • Cumberbatch, M., Dearman, R. J. and Kimber, I. Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin-1beta. Immunology 105, 466-477 (2002).
    • (2002) Immunology , vol.105 , pp. 466-477
    • Cumberbatch, M.1    Dearman, R.J.2    Kimber, I.3
  • 21
    • 77953854915 scopus 로고    scopus 로고
    • Leukocyte function in the aging immune system
    • Desai, A., Grolleau-Julius, A. and Yung, R. Leukocyte function in the aging immune system. J. Leukoc. Biol. 87, 1001-1009 (2010).
    • (2010) J. Leukoc. Biol. , vol.87 , pp. 1001-1009
    • Desai, A.1    Grolleau-Julius, A.2    Yung, R.3
  • 22
    • 84949495879 scopus 로고    scopus 로고
    • Aging impairs the ability of conventional dendritic cells to cross-prime CD8+ T cells upon stimulation with a TLR7 ligand
    • Zacca, E. R. et al. Aging impairs the ability of conventional dendritic cells to cross-prime CD8+ T cells upon stimulation with a TLR7 ligand. PLoS One 10, e0140672 (2015).
    • (2015) PLoS One , vol.10 , pp. e0140672
    • Zacca, E.R.1
  • 23
    • 84941799579 scopus 로고    scopus 로고
    • Loss of phagocytic and antigen cross-presenting capacity in aging dendritic cells is associated with mitochondrial dysfunction
    • Chougnet, C. A. et al. Loss of phagocytic and antigen cross-presenting capacity in aging dendritic cells is associated with mitochondrial dysfunction. J. Immunol. 195, 2624-2632 (2015).
    • (2015) J. Immunol. , vol.195 , pp. 2624-2632
    • Chougnet, C.A.1
  • 24
    • 85023193088 scopus 로고    scopus 로고
    • Cutting edge: The aging immune system reveals the biological impact of direct antigen presentation on CD8 T cell responses
    • Uhrlaub, J. L., Smithey, M. J. and Nikolich-Zugich, J. Cutting edge: the aging immune system reveals the biological impact of direct antigen presentation on CD8 T cell responses. J. Immunol. 199, 403-407 (2017).
    • (2017) J. Immunol. , vol.199 , pp. 403-407
    • Uhrlaub, J.L.1    Smithey, M.J.2    Nikolich-Zugich, J.3
  • 25
    • 84055190787 scopus 로고    scopus 로고
    • Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice
    • Zhao, J., Zhao, J., Legge, K. and Perlman, S. Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. J. Clin. Invest. 121, 4921-4930 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 4921-4930
    • Zhao, J.1    Zhao, J.2    Legge, K.3    Perlman, S.4
  • 27
    • 0033559509 scopus 로고    scopus 로고
    • B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation
    • Kline, G. H., Hayden, T. A. and Klinman, N. R. B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation. J. Immunol. 162, 3342-3349 (1999).
    • (1999) J. Immunol , vol.162 , pp. 3342-3349
    • Kline, G.H.1    Hayden, T.A.2    Klinman, N.R.3
  • 28
    • 0031568406 scopus 로고    scopus 로고
    • Development of B cells in aged mice: Decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors
    • Stephan, R. P., Lill-Elghanian, D. A. and Witte, P. L. Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors. J. Immunol. 158, 1598-1609 (1997).
    • (1997) J. Immunol. , vol.158 , pp. 1598-1609
    • Stephan, R.P.1    Lill-Elghanian, D.A.2    Witte, P.L.3
  • 29
    • 84907001176 scopus 로고    scopus 로고
    • Diversity and clonal selection in the human T-cell repertoire
    • Qi, Q. et al. Diversity and clonal selection in the human T-cell repertoire. Proc. Natl. Acad. Sci. USA 111, 13139-13144 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 13139-13144
    • Qi, Q.1
  • 30
    • 85015749143 scopus 로고    scopus 로고
    • Longterm maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites
    • Thome, J. J. et al. Longterm maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites. Sci. Immunol. 1, eaah6506 (2016).
    • (2016) Sci. Immunol. , vol.1 , pp. eaah6506
    • Thome, J.J.1
  • 31
    • 79951821255 scopus 로고    scopus 로고
    • Evolution of the antigen-specific CD8+ TCR repertoire across the life span: Evidence for clonal homogenization of the old TCR repertoire
    • Rudd, B. D., Venturi, V., Davenport, M. P. and Nikolich-Zugich, J. Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire. J. Immunol. 186, 2056-2064 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 2056-2064
    • Rudd, B.D.1    Venturi, V.2    Davenport, M.P.3    Nikolich-Zugich, J.4
  • 32
    • 79956105098 scopus 로고    scopus 로고
    • Normal T cell homeostasis: The conversion of naive cells into memory-phenotype cells
    • Sprent, J. and Surh, C. D. Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nat. Immunol. 12, 478-484 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 478-484
    • Sprent, J.1    Surh, C.D.2
  • 33
    • 85021234957 scopus 로고    scopus 로고
    • Functional and homeostatic impact of age-related changes in lymph node stroma
    • Thompson, H. L., Smithey, M. J., Surh, C. D. and Nikolich-Zugich, J. Functional and homeostatic impact of age-related changes in lymph node stroma. Front. Immunol. 8, 706 (2017).
    • (2017) Front. Immunol. , vol.8 , pp. 706
    • Thompson, H.L.1    Smithey, M.J.2    Surh, C.D.3    Nikolich-Zugich, J.4
  • 34
    • 20344364855 scopus 로고    scopus 로고
    • Immunosenescence: A problem of lymphopoiesis, homeostasis, microenvironment, and signaling
    • Cambier, J. Immunosenescence: a problem of lymphopoiesis, homeostasis, microenvironment, and signaling. Immunol. Rev. 205, 5-6 (2005).
    • (2005) Immunol. Rev. , vol.205 , pp. 5-6
    • Cambier, J.1
  • 35
    • 84896501298 scopus 로고    scopus 로고
    • Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans
    • Wertheimer, A. M. et al. Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans. J. Immunol. 192, 2143-2155 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 2143-2155
    • Wertheimer, A.M.1
  • 36
    • 80051970221 scopus 로고    scopus 로고
    • Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions
    • Rudd, B. D. et al. Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions. Proc. Natl. Acad. Sci. USA 108, 13694-13699 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 13694-13699
    • Rudd, B.D.1
  • 38
    • 80051569441 scopus 로고    scopus 로고
    • A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice
    • Hao, Y., O'Neill, P., Naradikian, M. S., Scholz, J. L. and Cancro, M. P. A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice. Blood 118, 1294-1304 (2011).
    • (2011) Blood , vol.118 , pp. 1294-1304
    • Hao, Y.1    O'Neill, P.2    Naradikian, M.S.3    Scholz, J.L.4    Cancro, M.P.5
  • 39
    • 84982672463 scopus 로고    scopus 로고
    • The aged lymphoid tissue environment fails to support naïve T cell homeostasis
    • Becklund, B. R. et al. The aged lymphoid tissue environment fails to support naïve T cell homeostasis. Sci. Rep 6, 30842 (2016).
    • (2016) Sci. Rep , vol.6 , pp. 30842
    • Becklund, B.R.1
  • 40
    • 84856844011 scopus 로고    scopus 로고
    • Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors
    • Decman, V. et al. Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors. J. Immunol. 188, 1933-1941 (2012).
    • (2012) J. Immunol. , vol.188 , pp. 1933-1941
    • Decman, V.1
  • 41
    • 84891060089 scopus 로고    scopus 로고
    • Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging
    • Renkema, K. R., Li, G., Wu, A., Smithey, M. J. and Nikolich-Zugich, J. Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging. J. Immunol. 192, 151-159 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 151-159
    • Renkema, K.R.1    Li, G.2    Wu, A.3    Smithey, M.J.4    Nikolich-Zugich, J.5
  • 42
    • 84890424358 scopus 로고    scopus 로고
    • Cutting edge: Central memory CD8 T cells in aged mice are virtual memory cells
    • Chiu, B. C., Martin, B. E., Stolberg, V. R. and Chensue, S. W. Cutting edge: Central memory CD8 T cells in aged mice are virtual memory cells. J. Immunol. 191, 5793-5796 (2013).
    • (2013) J. Immunol. , vol.191 , pp. 5793-5796
    • Chiu, B.C.1    Martin, B.E.2    Stolberg, V.R.3    Chensue, S.W.4
  • 43
    • 0034468083 scopus 로고    scopus 로고
    • Enrichment of immediate-early 1 (m123/pp89) peptide-specific CD8 T cells in a pulmonary CD62Llo memory-effector cell pool during latent murine cytomegalovirus infection of the lungs
    • Holtappels, R., Pahl-Seibert, M. F., Thomas, D. and Reddehase, M. J. Enrichment of immediate-early 1 (m123/pp89) peptide-specific CD8 T cells in a pulmonary CD62Llo memory-effector cell pool during latent murine cytomegalovirus infection of the lungs. J. Virol. 74, 11495-11503 (2000).
    • (2000) J. Virol. , vol.74 , pp. 11495-11503
    • Holtappels, R.1    Pahl-Seibert, M.F.2    Thomas, D.3    Reddehase, M.J.4
  • 44
    • 33644833785 scopus 로고    scopus 로고
    • Genome-wide analysis reveals a highly diverse CD8 T cell response to murine cytomegalovirus
    • Munks, M. W. et al. Genome-wide analysis reveals a highly diverse CD8 T cell response to murine cytomegalovirus. J. Immunol. 176, 3760-3766 (2006).
    • (2006) J. Immunol. , vol.176 , pp. 3760-3766
    • Munks, M.W.1
  • 45
    • 24344489044 scopus 로고    scopus 로고
    • Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
    • Sylwester, A. W. et al. Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J. Exp. Med. 202, 673-685 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 673-685
    • Sylwester, A.W.1
  • 46
    • 85021194842 scopus 로고    scopus 로고
    • A constant companion: Immune recognition and response to cytomegalovirus with aging and implications for immune fitness
    • Souquette, A., Frere, J., Smithey, M., Sauce, D. and Thomas, P. G. A constant companion: immune recognition and response to cytomegalovirus with aging and implications for immune fitness. Geroscience 39, 293-303 (2017).
    • (2017) Geroscience , vol.39 , pp. 293-303
    • Souquette, A.1    Frere, J.2    Smithey, M.3    Sauce, D.4    Thomas, P.G.5
  • 47
    • 0842321787 scopus 로고    scopus 로고
    • Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase
    • Frasca, D., Van der Put, E., Riley, R. L. and Blomberg, B. B. Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase. J. Immunol. 172, 2155-2162 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 2155-2162
    • Frasca, D.1    Van Der Put, E.2    Riley, R.L.3    Blomberg, B.B.4
  • 48
    • 84964840120 scopus 로고    scopus 로고
    • The generation of memory B cells is maintained, but the antibody response is not, in the elderly after repeated influenza immunizations
    • Frasca, D., Diaz, A., Romero, M. and Blomberg, B. B. The generation of memory B cells is maintained, but the antibody response is not, in the elderly after repeated influenza immunizations. Vaccine 34, 2834-2840 (2016).
    • (2016) Vaccine , vol.34 , pp. 2834-2840
    • Frasca, D.1    Diaz, A.2    Romero, M.3    Blomberg, B.B.4
  • 49
    • 84938777751 scopus 로고    scopus 로고
    • Age-Dependent cell trafficking defects in draining lymph nodes impair adaptive immunity and control of West Nile virus infection
    • Richner, J. M. et al. Age-Dependent cell trafficking defects in draining lymph nodes impair adaptive immunity and control of West Nile virus infection. PLoS Pathog. 11, e1005027 (2015).
    • (2015) PLoS Pathog. , vol.11 , pp. e1005027
    • Richner, J.M.1
  • 50
    • 84937516776 scopus 로고    scopus 로고
    • Defective TFH cell function and increased TFR cells contribute to defective antibody production in aging
    • Sage, P. T., Tan, C. L., Freeman, G. J., Haigis, M. and Sharpe, A. H. Defective TFH cell function and increased TFR cells contribute to defective antibody production in aging. Cell Rep. 12, 163-171 (2015).
    • (2015) Cell Rep. , vol.12 , pp. 163-171
    • Sage, P.T.1    Tan, C.L.2    Freeman, G.J.3    Haigis, M.4    Sharpe, A.H.5
  • 51
    • 0020340236 scopus 로고
    • Limiting dilution analysis of IL-2 production: Studies of age, genotype, and regulatory interactions
    • Miller, R. A. and Stutman, O. Limiting dilution analysis of IL-2 production: studies of age, genotype, and regulatory interactions. Lymphokine Res. 1, 79-86 (1982).
    • (1982) Lymphokine Res. , vol.1 , pp. 79-86
    • Miller, R.A.1    Stutman, O.2
  • 52
    • 0020500246 scopus 로고
    • The immune response of aged mice to influenza: Diminished T-cell proliferation, interleukin 2 production and cytotoxicity
    • Effros, R. B. and Walford, R. L. The immune response of aged mice to influenza: diminished T-cell proliferation, interleukin 2 production and cytotoxicity. Cell. Immunol. 81, 298-305 (1983).
    • (1983) Cell. Immunol. , vol.81 , pp. 298-305
    • Effros, R.B.1    Walford, R.L.2
  • 53
    • 84870293512 scopus 로고    scopus 로고
    • Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
    • Li, G. et al. Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat. Med. 18, 1518-1524 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 1518-1524
    • Li, G.1
  • 54
    • 38449083181 scopus 로고    scopus 로고
    • Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells
    • Garcia, G. G., Sadighi Akha, A. A. and Miller, R. A. Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells. J. Immunol. 179, 6403-6409 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 6403-6409
    • Garcia, G.G.1    Sadighi Akha, A.A.2    Miller, R.A.3
  • 55
    • 0031561783 scopus 로고    scopus 로고
    • Differential tyrosine phosphorylation of zeta chain dimers in mouse CD4 T lymphocytes: Effect of age
    • Garcia, G. G. and Miller, R. A. Differential tyrosine phosphorylation of zeta chain dimers in mouse CD4 T lymphocytes: effect of age. Cell. Immunol. 175, 51-57 (1997).
    • (1997) Cell. Immunol. , vol.175 , pp. 51-57
    • Garcia, G.G.1    Miller, R.A.2
  • 56
    • 78650249228 scopus 로고    scopus 로고
    • Age-related defects in the cytoskeleton signaling pathways of CD4 T cells
    • Garcia, G. G. and Miller, R. A. Age-related defects in the cytoskeleton signaling pathways of CD4 T cells. Ageing Res. Rev. 10, 26-34 (2011).
    • (2011) Ageing Res. Rev. , vol.10 , pp. 26-34
    • Garcia, G.G.1    Miller, R.A.2
  • 57
    • 0033523712 scopus 로고    scopus 로고
    • Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice
    • Haynes, L., Linton, P. J., Eaton, S. M., Tonkonogy, S. L. and Swain, S. L. Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice. J. Exp. Med. 190, 1013-1024 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 1013-1024
    • Haynes, L.1    Linton, P.J.2    Eaton, S.M.3    Tonkonogy, S.L.4    Swain, S.L.5
  • 58
    • 0030963397 scopus 로고    scopus 로고
    • Age-related changes in CD4 T cells of T cell receptor transgenic mice
    • Haynes, L., Linton, P. J. and Swain, S. L. Age-related changes in CD4 T cells of T cell receptor transgenic mice. Mech. Ageing Dev. 93, 95-105 (1997).
    • (1997) Mech. Ageing Dev. , vol.93 , pp. 95-105
    • Haynes, L.1    Linton, P.J.2    Swain, S.L.3
  • 59
    • 70849110194 scopus 로고    scopus 로고
    • Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects
    • Tsukamoto, H. et al. Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects. Proc. Natl. Acad. Sci. USA 106, 18333-18338 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 18333-18338
    • Tsukamoto, H.1
  • 60
    • 78049499052 scopus 로고    scopus 로고
    • Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects
    • Tsukamoto, H., Huston, G. E., Dibble, J., Duso, D. K. and Swain, S. L. Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects. J. Immunol. 185, 4535-4544 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 4535-4544
    • Tsukamoto, H.1    Huston, G.E.2    Dibble, J.3    Duso, D.K.4    Swain, S.L.5
  • 61
    • 73349101903 scopus 로고    scopus 로고
    • Key role of T cell defects in age-related vulnerability to West Nile virus
    • Brien, J. D., Uhrlaub, J. L., Hirsch, A., Wiley, C. A. and Nikolich-Zugich, J. Key role of T cell defects in age-related vulnerability to West Nile virus. J. Exp. Med. 206, 2735-2745 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 2735-2745
    • Brien, J.D.1    Uhrlaub, J.L.2    Hirsch, A.3    Wiley, C.A.4    Nikolich-Zugich, J.5
  • 62
    • 79955127869 scopus 로고    scopus 로고
    • Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L.monocytogenes in old mice
    • Smithey, M. J., Renkema, K. R., Rudd, B. D. and Nikolich-Zugich, J. Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice. Eur. J. Immunol. 41, 1352-1364 (2011).
    • (2011) Eur. J. Immunol. , vol.41 , pp. 1352-1364
    • Smithey, M.J.1    Renkema, K.R.2    Rudd, B.D.3    Nikolich-Zugich, J.4
  • 63
    • 84992695872 scopus 로고    scopus 로고
    • Dysregulated TGF-β production underlies the age-related vulnerability to chikungunya virus
    • Uhrlaub, J. L. et al. Dysregulated TGF-β production underlies the age-related vulnerability to chikungunya virus. PLoS Pathog. 12, e1005891 (2016).
    • (2016) PLoS Pathog. , vol.12 , pp. e1005891
    • Uhrlaub, J.L.1
  • 64
    • 84868210702 scopus 로고    scopus 로고
    • Age-associated alterations in CD8β + dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium
    • Li, G., Smithey, M. J., Rudd, B. D. and Nikolich-Zugich, J. Age-associated alterations in CD8β + dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium. Aging Cell 11, 968-977 (2012).
    • (2012) Aging Cell , vol.11 , pp. 968-977
    • Li, G.1    Smithey, M.J.2    Rudd, B.D.3    Nikolich-Zugich, J.4
  • 65
    • 85016584336 scopus 로고    scopus 로고
    • Aging increases cell-to-cell transcriptional variability upon immune stimulation
    • Martinez-Jimenez, C. P. et al. Aging increases cell-to-cell transcriptional variability upon immune stimulation. Science 355, 1433-1436 (2017).
    • (2017) Science , vol.355 , pp. 1433-1436
    • Martinez-Jimenez, C.P.1
  • 66
    • 85015731741 scopus 로고    scopus 로고
    • Epigenomics of human CD8 T cell differentiation and aging
    • Moskowitz, D. M. et al. Epigenomics of human CD8 T cell differentiation and aging. Sci. Immunol. 2, eaag0192 (2017).
    • (2017) Sci. Immunol. , vol.2 , pp. eaag0192
    • Moskowitz, D.M.1
  • 67
    • 85030632976 scopus 로고    scopus 로고
    • The chromatin accessibility signature of human immune aging stems from CD8+ T cells
    • Ucar, D. et al. The chromatin accessibility signature of human immune aging stems from CD8+ T cells. J. Exp. Med. 214, 3123-3144 (2017).
    • (2017) J. Exp. Med. , vol.214 , pp. 3123-3144
    • Ucar, D.1
  • 68
    • 84976298029 scopus 로고    scopus 로고
    • Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses
    • Pulko, V. et al. Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses. Nat. Immunol. 17, 966-975 (2016).
    • (2016) Nat. Immunol. , vol.17 , pp. 966-975
    • Pulko, V.1
  • 69
    • 80052682032 scopus 로고    scopus 로고
    • Reversible senescence in human CD4+CD45RA+CD27-memory T cells
    • Di Mitri, D. et al. Reversible senescence in human CD4+CD45RA+CD27-memory T cells. J. Immunol. 187, 2093-2100 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 2093-2100
    • Di Mitri, D.1
  • 70
    • 85010910513 scopus 로고    scopus 로고
    • A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging
    • Lanna, A. et al. A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging. Nat. Immunol. 18, 354-363 (2017).
    • (2017) Nat. Immunol. , vol.18 , pp. 354-363
    • Lanna, A.1
  • 71
    • 15244348518 scopus 로고    scopus 로고
    • The origins of age-related proinflammatory state
    • Ferrucci, L. et al. The origins of age-related proinflammatory state. Blood 105, 2294-2299 (2005).
    • (2005) Blood , vol.105 , pp. 2294-2299
    • Ferrucci, L.1
  • 72
    • 16344376370 scopus 로고    scopus 로고
    • Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity
    • De Martinis, M., Franceschi, C., Monti, D. and Ginaldi, L. Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett 579, 2035-2039 (2005).
    • (2005) FEBS Lett , vol.579 , pp. 2035-2039
    • De Martinis, M.1    Franceschi, C.2    Monti, D.3    Ginaldi, L.4
  • 73
    • 0027265827 scopus 로고
    • Increased cytokine production in mononuclear cells of healthy elderly people
    • Fagiolo, U. et al. Increased cytokine production in mononuclear cells of healthy elderly people. Eur. J. Immunol. 23, 2375-2378 (1993).
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2375-2378
    • Fagiolo, U.1
  • 74
    • 84936769983 scopus 로고    scopus 로고
    • Associations of heart rate with inflammatory markers are modulated by gender and obesity in older adults
    • Laudisio, A., Bandinelli, S., Gemma, A., Ferrucci, L. and Incalzi, R. A. Associations of heart rate with inflammatory markers are modulated by gender and obesity in older adults. J. Gerontol. A Biol. Sci. Med. Sci 70, 899-904 (2015).
    • (2015) J. Gerontol. A Biol. Sci. Med. Sci , vol.70 , pp. 899-904
    • Laudisio, A.1    Bandinelli, S.2    Gemma, A.3    Ferrucci, L.4    Incalzi, R.A.5
  • 75
    • 68249096784 scopus 로고    scopus 로고
    • Persistent DNA damage signalling triggers senescenceassociated inflammatory cytokine secretion
    • Rodier, F. et al. Persistent DNA damage signalling triggers senescenceassociated inflammatory cytokine secretion. Nat. Cell Biol. 11, 973-979 (2009).
    • (2009) Nat. Cell Biol. , vol.11 , pp. 973-979
    • Rodier, F.1
  • 76
    • 84874603171 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities
    • Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J. and Kirkland, J. L. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J. Clin. Invest. 123, 966-972 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 966-972
    • Tchkonia, T.1    Zhu, Y.2    Van Deursen, J.3    Campisi, J.4    Kirkland, J.L.5
  • 77
    • 77949268329 scopus 로고    scopus 로고
    • The immunology of fibrosis: Innate and adaptive responses
    • Wick, G. et al. The immunology of fibrosis: innate and adaptive responses. Trends Immunol. 31, 110-119 (2010).
    • (2010) Trends Immunol. , vol.31 , pp. 110-119
    • Wick, G.1
  • 78
    • 84902145664 scopus 로고    scopus 로고
    • Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition
    • Bhadra, R. et al. Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition. J. Clin. Invest. 124, 2441-2455 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 2441-2455
    • Bhadra, R.1
  • 79
    • 84859969340 scopus 로고    scopus 로고
    • Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice
    • Sahin, H. et al. Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice. Hepatology 55, 1610-1619 (2012).
    • (2012) Hepatology , vol.55 , pp. 1610-1619
    • Sahin, H.1
  • 80
    • 57149093788 scopus 로고    scopus 로고
    • NK and NKT cells in liver injury and fibrosis
    • Notas, G., Kisseleva, T. and Brenner, D. NK and NKT cells in liver injury and fibrosis. Clin. Immunol. 130, 16-26 (2009).
    • (2009) Clin. Immunol. , vol.130 , pp. 16-26
    • Notas, G.1    Kisseleva, T.2    Brenner, D.3
  • 81
    • 84922572199 scopus 로고    scopus 로고
    • Fibroblastic reticular cells: Organization and regulation of the T lymphocyte life cycle
    • Brown, F. D. and Turley, S. J. Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle. J. Immunol. 194, 1389-1394 (2015).
    • (2015) J. Immunol. , vol.194 , pp. 1389-1394
    • Brown, F.D.1    Turley, S.J.2
  • 82
    • 35548975191 scopus 로고    scopus 로고
    • Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
    • Link, A. et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat. Immunol. 8, 1255-1265 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 1255-1265
    • Link, A.1
  • 83
    • 85015264987 scopus 로고    scopus 로고
    • Structural and functional changes to lymph nodes in ageing mice
    • Turner, V. M. and Mabbott, N. A. Structural and functional changes to lymph nodes in ageing mice. Immunology 151, 239-247 (2017).
    • (2017) Immunology , vol.151 , pp. 239-247
    • Turner, V.M.1    Mabbott, N.A.2
  • 84
    • 85021201208 scopus 로고    scopus 로고
    • Role of cell-intrinsic and environmental age-related changes in altered maintenance of murine T cells in lymphoid organs
    • Davies, J. S., Thompson, H. L., Pulko, V., Torres, J. P. and Nikolich-Zugich, J. Role of cell-intrinsic and environmental age-related changes in altered maintenance of murine T cells in lymphoid organs. J. Gerontol. A Biol. Sci. Med. Sci. http://dx.doi.org/10.1093/gerona/glx102 (2017).
    • (2017) J. Gerontol. A Biol. Sci. Med. Sci.
    • Davies, J.S.1    Thompson, H.L.2    Pulko, V.3    Torres, J.P.4    Nikolich-Zugich, J.5
  • 85
    • 69549133578 scopus 로고    scopus 로고
    • Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging
    • Agius, E. et al. Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging. J. Exp. Med. 206, 1929-1940 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1929-1940
    • Agius, E.1
  • 86
    • 0032935617 scopus 로고    scopus 로고
    • Influences of microbiota on intestinal immune system development
    • Cebra, J. J. Influences of microbiota on intestinal immune system development. Am. J. Clin. Nutr. 69, 1046S-1051S (1999).
    • (1999) Am. J. Clin. Nutr. , vol.69 , pp. 1046S-1051S
    • Cebra, J.J.1
  • 87
    • 20144363585 scopus 로고    scopus 로고
    • Recent immune status determines the source of antigens that drive homeostatic T cell expansion
    • Kieper, W. C. et al. Recent immune status determines the source of antigens that drive homeostatic T cell expansion. J. Immunol. 174, 3158-3163 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 3158-3163
    • Kieper, W.C.1
  • 88
    • 84864722033 scopus 로고    scopus 로고
    • Gut microbiota composition correlates with diet and health in the elderly
    • Claesson, M. J. et al. Gut microbiota composition correlates with diet and health in the elderly. Nature 488, 178-184 (2012).
    • (2012) Nature , vol.488 , pp. 178-184
    • Claesson, M.J.1
  • 89
    • 84867515511 scopus 로고    scopus 로고
    • Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults
    • Stehle, J. R. Jr. et al. Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults. J. Gerontol. A Biol. Sci. Med. Sci. 67, 1212-1218 (2012).
    • (2012) J. Gerontol. A Biol. Sci. Med. Sci. , vol.67 , pp. 1212-1218
    • Stehle, J.R.1
  • 90
    • 85007605412 scopus 로고    scopus 로고
    • Microvasculature remodeling in the mouse lower gut during inflammaging
    • Jeong, J. H. et al. Microvasculature remodeling in the mouse lower gut during inflammaging. Sci. Rep. 7, 39848 (2017).
    • (2017) Sci. Rep. , vol.7 , pp. 39848
    • Jeong, J.H.1
  • 91
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley, J. M. et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat. Med. 12, 1365-1371 (2006).
    • (2006) Nat. Med. , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1
  • 92
    • 84964918435 scopus 로고    scopus 로고
    • Normalizing the environment recapitulates adult human immune traits in laboratory mice
    • Beura, L. K. et al. Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature 532, 512-516 (2016).
    • (2016) Nature , vol.532 , pp. 512-516
    • Beura, L.K.1
  • 93
    • 85018471266 scopus 로고    scopus 로고
    • Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo
    • Woodward, N. C. et al. Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo. J. Neuroinflammation 14, 84 (2017).
    • (2017) J. Neuroinflammation , vol.14 , pp. 84
    • Woodward, N.C.1
  • 94
    • 84920982264 scopus 로고    scopus 로고
    • Variation in the human immune system is largely driven by non-heritable influences
    • Brodin, P. et al. Variation in the human immune system is largely driven by non-heritable influences. Cell 160, 37-47 (2015).
    • (2015) Cell , vol.160 , pp. 37-47
    • Brodin, P.1
  • 95
    • 85020499480 scopus 로고    scopus 로고
    • How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?
    • Aiello, A. E., Chiu, Y. L. and Frasca, D. How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms? Geroscience 39, 261-271 (2017).
    • (2017) Geroscience , vol.39 , pp. 261-271
    • Aiello, A.E.1    Chiu, Y.L.2    Frasca, D.3
  • 96
    • 84931574245 scopus 로고    scopus 로고
    • CMV infection of human sinusoidal endothelium regulates hepatic T cell recruitment and activation
    • Bruns, T. et al. CMV infection of human sinusoidal endothelium regulates hepatic T cell recruitment and activation. J. Hepatol. 63, 38-49 (2015).
    • (2015) J. Hepatol. , vol.63 , pp. 38-49
    • Bruns, T.1
  • 97
    • 84866145898 scopus 로고    scopus 로고
    • Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging
    • Cicin-Sain, L. et al. Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging. PLoS Pathog. 8, e1002849 (2012).
    • (2012) PLoS Pathog. , vol.8 , pp. e1002849
    • Cicin-Sain, L.1
  • 98
    • 84869776196 scopus 로고    scopus 로고
    • Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life
    • Smithey, M. J., Li, G., Venturi, V., Davenport, M. P. and Nikolich-Zugich, J. Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life. J. Immunol. 189, 5356-5366 (2012).
    • (2012) J. Immunol. , vol.189 , pp. 5356-5366
    • Smithey, M.J.1    Li, G.2    Venturi, V.3    Davenport, M.P.4    Nikolich-Zugich, J.5
  • 99
    • 84866149968 scopus 로고    scopus 로고
    • Immune senescence: Relative contributions of age and cytomegalovirus infection
    • Mekker, A. et al. Immune senescence: relative contributions of age and cytomegalovirus infection. PLoS Pathog. 8, e1002850 (2012).
    • (2012) PLoS Pathog. , vol.8 , pp. e1002850
    • Mekker, A.1
  • 100
    • 84945957906 scopus 로고    scopus 로고
    • Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections
    • Marandu, T. F. et al. Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections. J. Virol. 89, 11715-11717 (2015).
    • (2015) J. Virol. , vol.89 , pp. 11715-11717
    • Marandu, T.F.1
  • 101
    • 34249005003 scopus 로고    scopus 로고
    • Herpesvirus latency confers symbiotic protection from bacterial infection
    • Barton, E. S. et al. Herpesvirus latency confers symbiotic protection from bacterial infection. Nature 447, 326-329 (2007).
    • (2007) Nature , vol.447 , pp. 326-329
    • Barton, E.S.1
  • 102
    • 84926442317 scopus 로고    scopus 로고
    • Cytomegalovirus infection enhances the immune response to influenza
    • Furman, D. et al. Cytomegalovirus infection enhances the immune response to influenza. Sci. Transl. Med. 7, 281ra43 (2015).
    • (2015) Sci. Transl. Med. , vol.7 , pp. 281ra43
    • Furman, D.1
  • 103
    • 85021779908 scopus 로고    scopus 로고
    • Recent advances in CMV tropism, latency, and diagnosis during aging
    • Leng, S. X. et al. Recent advances in CMV tropism, latency, and diagnosis during aging. Geroscience 39, 251-259 (2017).
    • (2017) Geroscience , vol.39 , pp. 251-259
    • Leng, S.X.1
  • 104
    • 84929870153 scopus 로고    scopus 로고
    • Geriatric syndromes in older HIV-infected adults
    • Greene, M. et al. Geriatric syndromes in older HIV-infected adults. J. Acquir. Immune Defic. Syndr. 69, 161-167 (2015).
    • (2015) J. Acquir. Immune Defic. Syndr. , vol.69 , pp. 161-167
    • Greene, M.1
  • 106
    • 22744445281 scopus 로고    scopus 로고
    • Overview of caloric restriction and ageing
    • Masoro, E. J. Overview of caloric restriction and ageing. Mech. Ageing Dev. 126, 913-922 (2005).
    • (2005) Mech. Ageing Dev. , vol.126 , pp. 913-922
    • Masoro, E.J.1
  • 107
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Harrison, D. E. et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392-395 (2009).
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1
  • 108
    • 0032425810 scopus 로고    scopus 로고
    • Delayed immune aging in diet-restricted B6CBAT6 F1 mice is associated with preservation of naive T cells
    • Chen, J., Astle, C.M. and Harrison, D.E. Delayed immune aging in diet-restricted B6CBAT6 F1 mice is associated with preservation of naive T cells. Exp. Gerontol. 53A, B330-B337 (1998).
    • (1998) Exp. Gerontol. , vol.53 A , pp. B330-B337
    • Chen, J.1    Astle, C.M.2    Harrison, D.E.3
  • 109
    • 33845898766 scopus 로고    scopus 로고
    • Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates
    • Messaoudi, I. et al. Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. Proc. Natl. Acad. Sci. USA 103, 19448-19453 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 19448-19453
    • Messaoudi, I.1
  • 110
    • 84924356420 scopus 로고    scopus 로고
    • The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
    • Youm, Y. H. et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat. Med 21, 263-269 (2015).
    • (2015) Nat. Med , vol.21 , pp. 263-269
    • Youm, Y.H.1
  • 112
    • 84922636348 scopus 로고    scopus 로고
    • Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms
    • Goldberg, E. L. et al. Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms. Aging Cell 14, 130-138 (2015).
    • (2015) Aging Cell , vol.14 , pp. 130-138
    • Goldberg, E.L.1
  • 113
    • 84904264964 scopus 로고    scopus 로고
    • Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections
    • Goldberg, E. L., Smithey, M. J., Lutes, L. K., Uhrlaub, J. L. and NikolichZugich, J. Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections. J. Immunol. 193, 757-763 (2014).
    • (2014) J. Immunol. , vol.193 , pp. 757-763
    • Goldberg, E.L.1    Smithey, M.J.2    Lutes, L.K.3    Uhrlaub, J.L.4    Nikolichugich, J.5
  • 114
    • 84919756169 scopus 로고    scopus 로고
    • MTOR inhibition improves immune function in the elderly
    • Mannick, J. B. et al. mTOR inhibition improves immune function in the elderly. Sci. Transl. Med. 6, 268ra179 (2014).
    • (2014) Sci. Transl. Med. , vol.6 , pp. 268ra179
    • Mannick, J.B.1


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