-
1
-
-
16244361901
-
-
(Humana Press, Totowa, NJ)
-
Albright, J. F. and Albright, J. W. Aging, Immunity, and Infection (Humana Press, Totowa, NJ, 2003).
-
(2003)
Aging, Immunity, and Infection
-
-
Albright, J.F.1
Albright, J.W.2
-
2
-
-
2142644403
-
Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo
-
Haynes, L., Eaton, S. M., Burns, E. M., Rincon, M. and Swain, S. L. Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo. J. Immunol. 172, 5194-5199 (2004).
-
(2004)
J. Immunol.
, vol.172
, pp. 5194-5199
-
-
Haynes, L.1
Eaton, S.M.2
Burns, E.M.3
Rincon, M.4
Swain, S.L.5
-
3
-
-
38649132010
-
CpG-ODN but not other TLR-ligands restore the antitumor responses in old mice: The implications for vaccinations in the aged
-
Sharma, S., Dominguez, A. L., Hoelzinger, D. B. and Lustgarten, J. CpG-ODN but not other TLR-ligands restore the antitumor responses in old mice: the implications for vaccinations in the aged. Cancer Immunol. Immunother. 57, 549-561 (2008).
-
(2008)
Cancer Immunol. Immunother.
, vol.57
, pp. 549-561
-
-
Sharma, S.1
Dominguez, A.L.2
Hoelzinger, D.B.3
Lustgarten, J.4
-
4
-
-
84929850029
-
Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults
-
Lal, H. et al. Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N. Engl. J. Med. 372, 2087-2096 (2015).
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 2087-2096
-
-
Lal, H.1
-
5
-
-
84921634186
-
Aging of the T cell compartment in mice and humans: From no naive expectations to foggy memories
-
Nikolich-Zugich, J. Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories. J. Immunol. 193, 2622-2629 (2014).
-
(2014)
J. Immunol.
, vol.193
, pp. 2622-2629
-
-
Nikolich-Zugich, J.1
-
6
-
-
84939881933
-
Innate immunesenescence: Underlying mechanisms and clinical relevance
-
Hazeldine, J. and Lord, J. M. Innate immunesenescence: underlying mechanisms and clinical relevance. Biogerontology 16, 187-201 (2015).
-
(2015)
Biogerontology
, vol.16
, pp. 187-201
-
-
Hazeldine, J.1
Lord, J.M.2
-
7
-
-
84948972267
-
Paradoxical changes in innate immunity in aging: Recent progress and new directions
-
Montgomery, R. R. and Shaw, A. C. Paradoxical changes in innate immunity in aging: recent progress and new directions. J. Leukoc. Biol. 98, 937-943 (2015).
-
(2015)
J. Leukoc. Biol.
, vol.98
, pp. 937-943
-
-
Montgomery, R.R.1
Shaw, A.C.2
-
8
-
-
84984698714
-
Glimpse of natural selection of long-lived T-cell clones in healthy life
-
Zhang, B. et al. Glimpse of natural selection of long-lived T-cell clones in healthy life. Proc. Natl. Acad. Sci. USA 113, 9858-9863 (2016).
-
(2016)
Proc. Natl. Acad. Sci. USA
, vol.113
, pp. 9858-9863
-
-
Zhang, B.1
-
9
-
-
0035975703
-
Neutrophil ageing and immunesenescence
-
Lord, J. M., Butcher, S., Killampali, V., Lascelles, D. and Salmon, M. Neutrophil ageing and immunesenescence. Mech. Ageing Dev. 122, 1521-1535 (2001).
-
(2001)
Mech. Ageing Dev.
, vol.122
, pp. 1521-1535
-
-
Lord, J.M.1
Butcher, S.2
Killampali, V.3
Lascelles, D.4
Salmon, M.5
-
10
-
-
77955664688
-
Aging of the innate immune system
-
Shaw, A. C., Joshi, S., Greenwood, H., Panda, A. and Lord, J. M. Aging of the innate immune system. Curr. Opin. Immunol. 22, 507-513 (2010).
-
(2010)
Curr. Opin. Immunol.
, vol.22
, pp. 507-513
-
-
Shaw, A.C.1
Joshi, S.2
Greenwood, H.3
Panda, A.4
Lord, J.M.5
-
11
-
-
84868193217
-
Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans
-
Solana, R. et al. Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. Semin. Immunol. 24, 331-341 (2012).
-
(2012)
Semin. Immunol.
, vol.24
, pp. 331-341
-
-
Solana, R.1
-
12
-
-
79951722208
-
Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis
-
Simell, B. et al. Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis. Vaccine 29, 1929-1934 (2011).
-
(2011)
Vaccine
, vol.29
, pp. 1929-1934
-
-
Simell, B.1
-
13
-
-
84864378864
-
Innate immune dysfunctions in aged mice facilitate the systemic dissemination of methicillin-resistant S.aureus
-
Tseng, C. W. et al. Innate immune dysfunctions in aged mice facilitate the systemic dissemination of methicillin-resistant S. aureus. PLoS One 7, e41454 (2012).
-
(2012)
PLoS One
, vol.7
, pp. e41454
-
-
Tseng, C.W.1
-
14
-
-
33846208784
-
Age-associated defect in human TLR-1/2 function
-
van Duin, D. et al. Age-associated defect in human TLR-1/2 function. J. Immunol. 178, 970-975 (2007).
-
(2007)
J. Immunol.
, vol.178
, pp. 970-975
-
-
Van Duin, D.1
-
15
-
-
84939516469
-
Age-related changes in natural killer cell repertoires: Impact on NK cell function and immune surveillance
-
Manser, A. R. and Uhrberg, M. Age-related changes in natural killer cell repertoires: impact on NK cell function and immune surveillance. Cancer Immunol. Immunother. 65, 417-426 (2016).
-
(2016)
Cancer Immunol. Immunother.
, vol.65
, pp. 417-426
-
-
Manser, A.R.1
Uhrberg, M.2
-
16
-
-
78149319109
-
Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking
-
Fang, M., Roscoe, F. and Sigal, L. J. Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking. J. Exp. Med. 207, 2369-2381 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2369-2381
-
-
Fang, M.1
Roscoe, F.2
Sigal, L.J.3
-
17
-
-
43349104959
-
Ageing is associated with diminished apoptotic cell clearance in vivo
-
Aprahamian, T., Takemura, Y., Goukassian, D. and Walsh, K. Ageing is associated with diminished apoptotic cell clearance in vivo. Clin. Exp. Immunol. 152, 448-455 (2008).
-
(2008)
Clin. Exp. Immunol.
, vol.152
, pp. 448-455
-
-
Aprahamian, T.1
Takemura, Y.2
Goukassian, D.3
Walsh, K.4
-
18
-
-
84927711067
-
Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors
-
Metcalf, T. U. et al. Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors. Aging Cell 14, 421-432 (2015).
-
(2015)
Aging Cell
, vol.14
, pp. 421-432
-
-
Metcalf, T.U.1
-
19
-
-
85027359896
-
Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists
-
Metcalf, T. U. et al. Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists. J. Immunol. 199, 1405-1417 (2017).
-
(2017)
J. Immunol.
, vol.199
, pp. 1405-1417
-
-
Metcalf, T.U.1
-
20
-
-
0036231373
-
Influence of ageing on Langerhans cell migration in mice: Identification of a putative deficiency of epidermal interleukin-1beta
-
Cumberbatch, M., Dearman, R. J. and Kimber, I. Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin-1beta. Immunology 105, 466-477 (2002).
-
(2002)
Immunology
, vol.105
, pp. 466-477
-
-
Cumberbatch, M.1
Dearman, R.J.2
Kimber, I.3
-
21
-
-
77953854915
-
Leukocyte function in the aging immune system
-
Desai, A., Grolleau-Julius, A. and Yung, R. Leukocyte function in the aging immune system. J. Leukoc. Biol. 87, 1001-1009 (2010).
-
(2010)
J. Leukoc. Biol.
, vol.87
, pp. 1001-1009
-
-
Desai, A.1
Grolleau-Julius, A.2
Yung, R.3
-
22
-
-
84949495879
-
Aging impairs the ability of conventional dendritic cells to cross-prime CD8+ T cells upon stimulation with a TLR7 ligand
-
Zacca, E. R. et al. Aging impairs the ability of conventional dendritic cells to cross-prime CD8+ T cells upon stimulation with a TLR7 ligand. PLoS One 10, e0140672 (2015).
-
(2015)
PLoS One
, vol.10
, pp. e0140672
-
-
Zacca, E.R.1
-
23
-
-
84941799579
-
Loss of phagocytic and antigen cross-presenting capacity in aging dendritic cells is associated with mitochondrial dysfunction
-
Chougnet, C. A. et al. Loss of phagocytic and antigen cross-presenting capacity in aging dendritic cells is associated with mitochondrial dysfunction. J. Immunol. 195, 2624-2632 (2015).
-
(2015)
J. Immunol.
, vol.195
, pp. 2624-2632
-
-
Chougnet, C.A.1
-
24
-
-
85023193088
-
Cutting edge: The aging immune system reveals the biological impact of direct antigen presentation on CD8 T cell responses
-
Uhrlaub, J. L., Smithey, M. J. and Nikolich-Zugich, J. Cutting edge: the aging immune system reveals the biological impact of direct antigen presentation on CD8 T cell responses. J. Immunol. 199, 403-407 (2017).
-
(2017)
J. Immunol.
, vol.199
, pp. 403-407
-
-
Uhrlaub, J.L.1
Smithey, M.J.2
Nikolich-Zugich, J.3
-
25
-
-
84055190787
-
Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice
-
Zhao, J., Zhao, J., Legge, K. and Perlman, S. Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. J. Clin. Invest. 121, 4921-4930 (2011).
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 4921-4930
-
-
Zhao, J.1
Zhao, J.2
Legge, K.3
Perlman, S.4
-
26
-
-
84868197943
-
Changes in primary lymphoid organs with aging
-
Chinn, I. K., Blackburn, C. C., Manley, N. R. and Sempowski, G. D. Changes in primary lymphoid organs with aging. Semin. Immunol. 24, 309-320 (2012).
-
(2012)
Semin. Immunol.
, vol.24
, pp. 309-320
-
-
Chinn, I.K.1
Blackburn, C.C.2
Manley, N.R.3
Sempowski, G.D.4
-
27
-
-
0033559509
-
B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation
-
Kline, G. H., Hayden, T. A. and Klinman, N. R. B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation. J. Immunol. 162, 3342-3349 (1999).
-
(1999)
J. Immunol
, vol.162
, pp. 3342-3349
-
-
Kline, G.H.1
Hayden, T.A.2
Klinman, N.R.3
-
28
-
-
0031568406
-
Development of B cells in aged mice: Decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors
-
Stephan, R. P., Lill-Elghanian, D. A. and Witte, P. L. Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors. J. Immunol. 158, 1598-1609 (1997).
-
(1997)
J. Immunol.
, vol.158
, pp. 1598-1609
-
-
Stephan, R.P.1
Lill-Elghanian, D.A.2
Witte, P.L.3
-
29
-
-
84907001176
-
Diversity and clonal selection in the human T-cell repertoire
-
Qi, Q. et al. Diversity and clonal selection in the human T-cell repertoire. Proc. Natl. Acad. Sci. USA 111, 13139-13144 (2014).
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 13139-13144
-
-
Qi, Q.1
-
30
-
-
85015749143
-
Longterm maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites
-
Thome, J. J. et al. Longterm maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites. Sci. Immunol. 1, eaah6506 (2016).
-
(2016)
Sci. Immunol.
, vol.1
, pp. eaah6506
-
-
Thome, J.J.1
-
31
-
-
79951821255
-
Evolution of the antigen-specific CD8+ TCR repertoire across the life span: Evidence for clonal homogenization of the old TCR repertoire
-
Rudd, B. D., Venturi, V., Davenport, M. P. and Nikolich-Zugich, J. Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire. J. Immunol. 186, 2056-2064 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 2056-2064
-
-
Rudd, B.D.1
Venturi, V.2
Davenport, M.P.3
Nikolich-Zugich, J.4
-
32
-
-
79956105098
-
Normal T cell homeostasis: The conversion of naive cells into memory-phenotype cells
-
Sprent, J. and Surh, C. D. Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nat. Immunol. 12, 478-484 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 478-484
-
-
Sprent, J.1
Surh, C.D.2
-
33
-
-
85021234957
-
Functional and homeostatic impact of age-related changes in lymph node stroma
-
Thompson, H. L., Smithey, M. J., Surh, C. D. and Nikolich-Zugich, J. Functional and homeostatic impact of age-related changes in lymph node stroma. Front. Immunol. 8, 706 (2017).
-
(2017)
Front. Immunol.
, vol.8
, pp. 706
-
-
Thompson, H.L.1
Smithey, M.J.2
Surh, C.D.3
Nikolich-Zugich, J.4
-
34
-
-
20344364855
-
Immunosenescence: A problem of lymphopoiesis, homeostasis, microenvironment, and signaling
-
Cambier, J. Immunosenescence: a problem of lymphopoiesis, homeostasis, microenvironment, and signaling. Immunol. Rev. 205, 5-6 (2005).
-
(2005)
Immunol. Rev.
, vol.205
, pp. 5-6
-
-
Cambier, J.1
-
35
-
-
84896501298
-
Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans
-
Wertheimer, A. M. et al. Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans. J. Immunol. 192, 2143-2155 (2014).
-
(2014)
J. Immunol.
, vol.192
, pp. 2143-2155
-
-
Wertheimer, A.M.1
-
36
-
-
80051970221
-
Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions
-
Rudd, B. D. et al. Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions. Proc. Natl. Acad. Sci. USA 108, 13694-13699 (2011).
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 13694-13699
-
-
Rudd, B.D.1
-
37
-
-
84868214102
-
B cell maintenance and function in aging
-
Kogut, I., Scholz, J. L., Cancro, M. P. and Cambier, J. C. B cell maintenance and function in aging. Semin. Immunol. 24, 342-349 (2012).
-
(2012)
Semin. Immunol.
, vol.24
, pp. 342-349
-
-
Kogut, I.1
Scholz, J.L.2
Cancro, M.P.3
Cambier, J.C.4
-
38
-
-
80051569441
-
A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice
-
Hao, Y., O'Neill, P., Naradikian, M. S., Scholz, J. L. and Cancro, M. P. A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice. Blood 118, 1294-1304 (2011).
-
(2011)
Blood
, vol.118
, pp. 1294-1304
-
-
Hao, Y.1
O'Neill, P.2
Naradikian, M.S.3
Scholz, J.L.4
Cancro, M.P.5
-
39
-
-
84982672463
-
The aged lymphoid tissue environment fails to support naïve T cell homeostasis
-
Becklund, B. R. et al. The aged lymphoid tissue environment fails to support naïve T cell homeostasis. Sci. Rep 6, 30842 (2016).
-
(2016)
Sci. Rep
, vol.6
, pp. 30842
-
-
Becklund, B.R.1
-
40
-
-
84856844011
-
Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors
-
Decman, V. et al. Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors. J. Immunol. 188, 1933-1941 (2012).
-
(2012)
J. Immunol.
, vol.188
, pp. 1933-1941
-
-
Decman, V.1
-
41
-
-
84891060089
-
Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging
-
Renkema, K. R., Li, G., Wu, A., Smithey, M. J. and Nikolich-Zugich, J. Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging. J. Immunol. 192, 151-159 (2014).
-
(2014)
J. Immunol.
, vol.192
, pp. 151-159
-
-
Renkema, K.R.1
Li, G.2
Wu, A.3
Smithey, M.J.4
Nikolich-Zugich, J.5
-
42
-
-
84890424358
-
Cutting edge: Central memory CD8 T cells in aged mice are virtual memory cells
-
Chiu, B. C., Martin, B. E., Stolberg, V. R. and Chensue, S. W. Cutting edge: Central memory CD8 T cells in aged mice are virtual memory cells. J. Immunol. 191, 5793-5796 (2013).
-
(2013)
J. Immunol.
, vol.191
, pp. 5793-5796
-
-
Chiu, B.C.1
Martin, B.E.2
Stolberg, V.R.3
Chensue, S.W.4
-
43
-
-
0034468083
-
Enrichment of immediate-early 1 (m123/pp89) peptide-specific CD8 T cells in a pulmonary CD62Llo memory-effector cell pool during latent murine cytomegalovirus infection of the lungs
-
Holtappels, R., Pahl-Seibert, M. F., Thomas, D. and Reddehase, M. J. Enrichment of immediate-early 1 (m123/pp89) peptide-specific CD8 T cells in a pulmonary CD62Llo memory-effector cell pool during latent murine cytomegalovirus infection of the lungs. J. Virol. 74, 11495-11503 (2000).
-
(2000)
J. Virol.
, vol.74
, pp. 11495-11503
-
-
Holtappels, R.1
Pahl-Seibert, M.F.2
Thomas, D.3
Reddehase, M.J.4
-
44
-
-
33644833785
-
Genome-wide analysis reveals a highly diverse CD8 T cell response to murine cytomegalovirus
-
Munks, M. W. et al. Genome-wide analysis reveals a highly diverse CD8 T cell response to murine cytomegalovirus. J. Immunol. 176, 3760-3766 (2006).
-
(2006)
J. Immunol.
, vol.176
, pp. 3760-3766
-
-
Munks, M.W.1
-
45
-
-
24344489044
-
Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
-
Sylwester, A. W. et al. Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J. Exp. Med. 202, 673-685 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 673-685
-
-
Sylwester, A.W.1
-
46
-
-
85021194842
-
A constant companion: Immune recognition and response to cytomegalovirus with aging and implications for immune fitness
-
Souquette, A., Frere, J., Smithey, M., Sauce, D. and Thomas, P. G. A constant companion: immune recognition and response to cytomegalovirus with aging and implications for immune fitness. Geroscience 39, 293-303 (2017).
-
(2017)
Geroscience
, vol.39
, pp. 293-303
-
-
Souquette, A.1
Frere, J.2
Smithey, M.3
Sauce, D.4
Thomas, P.G.5
-
47
-
-
0842321787
-
Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase
-
Frasca, D., Van der Put, E., Riley, R. L. and Blomberg, B. B. Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase. J. Immunol. 172, 2155-2162 (2004).
-
(2004)
J. Immunol.
, vol.172
, pp. 2155-2162
-
-
Frasca, D.1
Van Der Put, E.2
Riley, R.L.3
Blomberg, B.B.4
-
48
-
-
84964840120
-
The generation of memory B cells is maintained, but the antibody response is not, in the elderly after repeated influenza immunizations
-
Frasca, D., Diaz, A., Romero, M. and Blomberg, B. B. The generation of memory B cells is maintained, but the antibody response is not, in the elderly after repeated influenza immunizations. Vaccine 34, 2834-2840 (2016).
-
(2016)
Vaccine
, vol.34
, pp. 2834-2840
-
-
Frasca, D.1
Diaz, A.2
Romero, M.3
Blomberg, B.B.4
-
49
-
-
84938777751
-
Age-Dependent cell trafficking defects in draining lymph nodes impair adaptive immunity and control of West Nile virus infection
-
Richner, J. M. et al. Age-Dependent cell trafficking defects in draining lymph nodes impair adaptive immunity and control of West Nile virus infection. PLoS Pathog. 11, e1005027 (2015).
-
(2015)
PLoS Pathog.
, vol.11
, pp. e1005027
-
-
Richner, J.M.1
-
50
-
-
84937516776
-
Defective TFH cell function and increased TFR cells contribute to defective antibody production in aging
-
Sage, P. T., Tan, C. L., Freeman, G. J., Haigis, M. and Sharpe, A. H. Defective TFH cell function and increased TFR cells contribute to defective antibody production in aging. Cell Rep. 12, 163-171 (2015).
-
(2015)
Cell Rep.
, vol.12
, pp. 163-171
-
-
Sage, P.T.1
Tan, C.L.2
Freeman, G.J.3
Haigis, M.4
Sharpe, A.H.5
-
51
-
-
0020340236
-
Limiting dilution analysis of IL-2 production: Studies of age, genotype, and regulatory interactions
-
Miller, R. A. and Stutman, O. Limiting dilution analysis of IL-2 production: studies of age, genotype, and regulatory interactions. Lymphokine Res. 1, 79-86 (1982).
-
(1982)
Lymphokine Res.
, vol.1
, pp. 79-86
-
-
Miller, R.A.1
Stutman, O.2
-
52
-
-
0020500246
-
The immune response of aged mice to influenza: Diminished T-cell proliferation, interleukin 2 production and cytotoxicity
-
Effros, R. B. and Walford, R. L. The immune response of aged mice to influenza: diminished T-cell proliferation, interleukin 2 production and cytotoxicity. Cell. Immunol. 81, 298-305 (1983).
-
(1983)
Cell. Immunol.
, vol.81
, pp. 298-305
-
-
Effros, R.B.1
Walford, R.L.2
-
53
-
-
84870293512
-
Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
-
Li, G. et al. Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat. Med. 18, 1518-1524 (2012).
-
(2012)
Nat. Med.
, vol.18
, pp. 1518-1524
-
-
Li, G.1
-
54
-
-
38449083181
-
Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells
-
Garcia, G. G., Sadighi Akha, A. A. and Miller, R. A. Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells. J. Immunol. 179, 6403-6409 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 6403-6409
-
-
Garcia, G.G.1
Sadighi Akha, A.A.2
Miller, R.A.3
-
55
-
-
0031561783
-
Differential tyrosine phosphorylation of zeta chain dimers in mouse CD4 T lymphocytes: Effect of age
-
Garcia, G. G. and Miller, R. A. Differential tyrosine phosphorylation of zeta chain dimers in mouse CD4 T lymphocytes: effect of age. Cell. Immunol. 175, 51-57 (1997).
-
(1997)
Cell. Immunol.
, vol.175
, pp. 51-57
-
-
Garcia, G.G.1
Miller, R.A.2
-
56
-
-
78650249228
-
Age-related defects in the cytoskeleton signaling pathways of CD4 T cells
-
Garcia, G. G. and Miller, R. A. Age-related defects in the cytoskeleton signaling pathways of CD4 T cells. Ageing Res. Rev. 10, 26-34 (2011).
-
(2011)
Ageing Res. Rev.
, vol.10
, pp. 26-34
-
-
Garcia, G.G.1
Miller, R.A.2
-
57
-
-
0033523712
-
Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice
-
Haynes, L., Linton, P. J., Eaton, S. M., Tonkonogy, S. L. and Swain, S. L. Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice. J. Exp. Med. 190, 1013-1024 (1999).
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1013-1024
-
-
Haynes, L.1
Linton, P.J.2
Eaton, S.M.3
Tonkonogy, S.L.4
Swain, S.L.5
-
58
-
-
0030963397
-
Age-related changes in CD4 T cells of T cell receptor transgenic mice
-
Haynes, L., Linton, P. J. and Swain, S. L. Age-related changes in CD4 T cells of T cell receptor transgenic mice. Mech. Ageing Dev. 93, 95-105 (1997).
-
(1997)
Mech. Ageing Dev.
, vol.93
, pp. 95-105
-
-
Haynes, L.1
Linton, P.J.2
Swain, S.L.3
-
59
-
-
70849110194
-
Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects
-
Tsukamoto, H. et al. Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects. Proc. Natl. Acad. Sci. USA 106, 18333-18338 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 18333-18338
-
-
Tsukamoto, H.1
-
60
-
-
78049499052
-
Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects
-
Tsukamoto, H., Huston, G. E., Dibble, J., Duso, D. K. and Swain, S. L. Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects. J. Immunol. 185, 4535-4544 (2010).
-
(2010)
J. Immunol.
, vol.185
, pp. 4535-4544
-
-
Tsukamoto, H.1
Huston, G.E.2
Dibble, J.3
Duso, D.K.4
Swain, S.L.5
-
61
-
-
73349101903
-
Key role of T cell defects in age-related vulnerability to West Nile virus
-
Brien, J. D., Uhrlaub, J. L., Hirsch, A., Wiley, C. A. and Nikolich-Zugich, J. Key role of T cell defects in age-related vulnerability to West Nile virus. J. Exp. Med. 206, 2735-2745 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 2735-2745
-
-
Brien, J.D.1
Uhrlaub, J.L.2
Hirsch, A.3
Wiley, C.A.4
Nikolich-Zugich, J.5
-
62
-
-
79955127869
-
Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L.monocytogenes in old mice
-
Smithey, M. J., Renkema, K. R., Rudd, B. D. and Nikolich-Zugich, J. Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice. Eur. J. Immunol. 41, 1352-1364 (2011).
-
(2011)
Eur. J. Immunol.
, vol.41
, pp. 1352-1364
-
-
Smithey, M.J.1
Renkema, K.R.2
Rudd, B.D.3
Nikolich-Zugich, J.4
-
63
-
-
84992695872
-
Dysregulated TGF-β production underlies the age-related vulnerability to chikungunya virus
-
Uhrlaub, J. L. et al. Dysregulated TGF-β production underlies the age-related vulnerability to chikungunya virus. PLoS Pathog. 12, e1005891 (2016).
-
(2016)
PLoS Pathog.
, vol.12
, pp. e1005891
-
-
Uhrlaub, J.L.1
-
64
-
-
84868210702
-
Age-associated alterations in CD8β + dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium
-
Li, G., Smithey, M. J., Rudd, B. D. and Nikolich-Zugich, J. Age-associated alterations in CD8β + dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium. Aging Cell 11, 968-977 (2012).
-
(2012)
Aging Cell
, vol.11
, pp. 968-977
-
-
Li, G.1
Smithey, M.J.2
Rudd, B.D.3
Nikolich-Zugich, J.4
-
65
-
-
85016584336
-
Aging increases cell-to-cell transcriptional variability upon immune stimulation
-
Martinez-Jimenez, C. P. et al. Aging increases cell-to-cell transcriptional variability upon immune stimulation. Science 355, 1433-1436 (2017).
-
(2017)
Science
, vol.355
, pp. 1433-1436
-
-
Martinez-Jimenez, C.P.1
-
66
-
-
85015731741
-
Epigenomics of human CD8 T cell differentiation and aging
-
Moskowitz, D. M. et al. Epigenomics of human CD8 T cell differentiation and aging. Sci. Immunol. 2, eaag0192 (2017).
-
(2017)
Sci. Immunol.
, vol.2
, pp. eaag0192
-
-
Moskowitz, D.M.1
-
67
-
-
85030632976
-
The chromatin accessibility signature of human immune aging stems from CD8+ T cells
-
Ucar, D. et al. The chromatin accessibility signature of human immune aging stems from CD8+ T cells. J. Exp. Med. 214, 3123-3144 (2017).
-
(2017)
J. Exp. Med.
, vol.214
, pp. 3123-3144
-
-
Ucar, D.1
-
68
-
-
84976298029
-
Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses
-
Pulko, V. et al. Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses. Nat. Immunol. 17, 966-975 (2016).
-
(2016)
Nat. Immunol.
, vol.17
, pp. 966-975
-
-
Pulko, V.1
-
69
-
-
80052682032
-
Reversible senescence in human CD4+CD45RA+CD27-memory T cells
-
Di Mitri, D. et al. Reversible senescence in human CD4+CD45RA+CD27-memory T cells. J. Immunol. 187, 2093-2100 (2011).
-
(2011)
J. Immunol.
, vol.187
, pp. 2093-2100
-
-
Di Mitri, D.1
-
70
-
-
85010910513
-
A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging
-
Lanna, A. et al. A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging. Nat. Immunol. 18, 354-363 (2017).
-
(2017)
Nat. Immunol.
, vol.18
, pp. 354-363
-
-
Lanna, A.1
-
71
-
-
15244348518
-
The origins of age-related proinflammatory state
-
Ferrucci, L. et al. The origins of age-related proinflammatory state. Blood 105, 2294-2299 (2005).
-
(2005)
Blood
, vol.105
, pp. 2294-2299
-
-
Ferrucci, L.1
-
72
-
-
16344376370
-
Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity
-
De Martinis, M., Franceschi, C., Monti, D. and Ginaldi, L. Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett 579, 2035-2039 (2005).
-
(2005)
FEBS Lett
, vol.579
, pp. 2035-2039
-
-
De Martinis, M.1
Franceschi, C.2
Monti, D.3
Ginaldi, L.4
-
73
-
-
0027265827
-
Increased cytokine production in mononuclear cells of healthy elderly people
-
Fagiolo, U. et al. Increased cytokine production in mononuclear cells of healthy elderly people. Eur. J. Immunol. 23, 2375-2378 (1993).
-
(1993)
Eur. J. Immunol.
, vol.23
, pp. 2375-2378
-
-
Fagiolo, U.1
-
74
-
-
84936769983
-
Associations of heart rate with inflammatory markers are modulated by gender and obesity in older adults
-
Laudisio, A., Bandinelli, S., Gemma, A., Ferrucci, L. and Incalzi, R. A. Associations of heart rate with inflammatory markers are modulated by gender and obesity in older adults. J. Gerontol. A Biol. Sci. Med. Sci 70, 899-904 (2015).
-
(2015)
J. Gerontol. A Biol. Sci. Med. Sci
, vol.70
, pp. 899-904
-
-
Laudisio, A.1
Bandinelli, S.2
Gemma, A.3
Ferrucci, L.4
Incalzi, R.A.5
-
75
-
-
68249096784
-
Persistent DNA damage signalling triggers senescenceassociated inflammatory cytokine secretion
-
Rodier, F. et al. Persistent DNA damage signalling triggers senescenceassociated inflammatory cytokine secretion. Nat. Cell Biol. 11, 973-979 (2009).
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 973-979
-
-
Rodier, F.1
-
76
-
-
84874603171
-
Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities
-
Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J. and Kirkland, J. L. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J. Clin. Invest. 123, 966-972 (2013).
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 966-972
-
-
Tchkonia, T.1
Zhu, Y.2
Van Deursen, J.3
Campisi, J.4
Kirkland, J.L.5
-
77
-
-
77949268329
-
The immunology of fibrosis: Innate and adaptive responses
-
Wick, G. et al. The immunology of fibrosis: innate and adaptive responses. Trends Immunol. 31, 110-119 (2010).
-
(2010)
Trends Immunol.
, vol.31
, pp. 110-119
-
-
Wick, G.1
-
78
-
-
84902145664
-
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition
-
Bhadra, R. et al. Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition. J. Clin. Invest. 124, 2441-2455 (2014).
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 2441-2455
-
-
Bhadra, R.1
-
79
-
-
84859969340
-
Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice
-
Sahin, H. et al. Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice. Hepatology 55, 1610-1619 (2012).
-
(2012)
Hepatology
, vol.55
, pp. 1610-1619
-
-
Sahin, H.1
-
80
-
-
57149093788
-
NK and NKT cells in liver injury and fibrosis
-
Notas, G., Kisseleva, T. and Brenner, D. NK and NKT cells in liver injury and fibrosis. Clin. Immunol. 130, 16-26 (2009).
-
(2009)
Clin. Immunol.
, vol.130
, pp. 16-26
-
-
Notas, G.1
Kisseleva, T.2
Brenner, D.3
-
81
-
-
84922572199
-
Fibroblastic reticular cells: Organization and regulation of the T lymphocyte life cycle
-
Brown, F. D. and Turley, S. J. Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle. J. Immunol. 194, 1389-1394 (2015).
-
(2015)
J. Immunol.
, vol.194
, pp. 1389-1394
-
-
Brown, F.D.1
Turley, S.J.2
-
82
-
-
35548975191
-
Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
-
Link, A. et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat. Immunol. 8, 1255-1265 (2007).
-
(2007)
Nat. Immunol.
, vol.8
, pp. 1255-1265
-
-
Link, A.1
-
83
-
-
85015264987
-
Structural and functional changes to lymph nodes in ageing mice
-
Turner, V. M. and Mabbott, N. A. Structural and functional changes to lymph nodes in ageing mice. Immunology 151, 239-247 (2017).
-
(2017)
Immunology
, vol.151
, pp. 239-247
-
-
Turner, V.M.1
Mabbott, N.A.2
-
84
-
-
85021201208
-
Role of cell-intrinsic and environmental age-related changes in altered maintenance of murine T cells in lymphoid organs
-
Davies, J. S., Thompson, H. L., Pulko, V., Torres, J. P. and Nikolich-Zugich, J. Role of cell-intrinsic and environmental age-related changes in altered maintenance of murine T cells in lymphoid organs. J. Gerontol. A Biol. Sci. Med. Sci. http://dx.doi.org/10.1093/gerona/glx102 (2017).
-
(2017)
J. Gerontol. A Biol. Sci. Med. Sci.
-
-
Davies, J.S.1
Thompson, H.L.2
Pulko, V.3
Torres, J.P.4
Nikolich-Zugich, J.5
-
85
-
-
69549133578
-
Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging
-
Agius, E. et al. Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging. J. Exp. Med. 206, 1929-1940 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1929-1940
-
-
Agius, E.1
-
86
-
-
0032935617
-
Influences of microbiota on intestinal immune system development
-
Cebra, J. J. Influences of microbiota on intestinal immune system development. Am. J. Clin. Nutr. 69, 1046S-1051S (1999).
-
(1999)
Am. J. Clin. Nutr.
, vol.69
, pp. 1046S-1051S
-
-
Cebra, J.J.1
-
87
-
-
20144363585
-
Recent immune status determines the source of antigens that drive homeostatic T cell expansion
-
Kieper, W. C. et al. Recent immune status determines the source of antigens that drive homeostatic T cell expansion. J. Immunol. 174, 3158-3163 (2005).
-
(2005)
J. Immunol.
, vol.174
, pp. 3158-3163
-
-
Kieper, W.C.1
-
88
-
-
84864722033
-
Gut microbiota composition correlates with diet and health in the elderly
-
Claesson, M. J. et al. Gut microbiota composition correlates with diet and health in the elderly. Nature 488, 178-184 (2012).
-
(2012)
Nature
, vol.488
, pp. 178-184
-
-
Claesson, M.J.1
-
89
-
-
84867515511
-
Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults
-
Stehle, J. R. Jr. et al. Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults. J. Gerontol. A Biol. Sci. Med. Sci. 67, 1212-1218 (2012).
-
(2012)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.67
, pp. 1212-1218
-
-
Stehle, J.R.1
-
90
-
-
85007605412
-
Microvasculature remodeling in the mouse lower gut during inflammaging
-
Jeong, J. H. et al. Microvasculature remodeling in the mouse lower gut during inflammaging. Sci. Rep. 7, 39848 (2017).
-
(2017)
Sci. Rep.
, vol.7
, pp. 39848
-
-
Jeong, J.H.1
-
91
-
-
33845532053
-
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
-
Brenchley, J. M. et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat. Med. 12, 1365-1371 (2006).
-
(2006)
Nat. Med.
, vol.12
, pp. 1365-1371
-
-
Brenchley, J.M.1
-
92
-
-
84964918435
-
Normalizing the environment recapitulates adult human immune traits in laboratory mice
-
Beura, L. K. et al. Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature 532, 512-516 (2016).
-
(2016)
Nature
, vol.532
, pp. 512-516
-
-
Beura, L.K.1
-
93
-
-
85018471266
-
Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo
-
Woodward, N. C. et al. Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo. J. Neuroinflammation 14, 84 (2017).
-
(2017)
J. Neuroinflammation
, vol.14
, pp. 84
-
-
Woodward, N.C.1
-
94
-
-
84920982264
-
Variation in the human immune system is largely driven by non-heritable influences
-
Brodin, P. et al. Variation in the human immune system is largely driven by non-heritable influences. Cell 160, 37-47 (2015).
-
(2015)
Cell
, vol.160
, pp. 37-47
-
-
Brodin, P.1
-
95
-
-
85020499480
-
How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?
-
Aiello, A. E., Chiu, Y. L. and Frasca, D. How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms? Geroscience 39, 261-271 (2017).
-
(2017)
Geroscience
, vol.39
, pp. 261-271
-
-
Aiello, A.E.1
Chiu, Y.L.2
Frasca, D.3
-
96
-
-
84931574245
-
CMV infection of human sinusoidal endothelium regulates hepatic T cell recruitment and activation
-
Bruns, T. et al. CMV infection of human sinusoidal endothelium regulates hepatic T cell recruitment and activation. J. Hepatol. 63, 38-49 (2015).
-
(2015)
J. Hepatol.
, vol.63
, pp. 38-49
-
-
Bruns, T.1
-
97
-
-
84866145898
-
Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging
-
Cicin-Sain, L. et al. Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging. PLoS Pathog. 8, e1002849 (2012).
-
(2012)
PLoS Pathog.
, vol.8
, pp. e1002849
-
-
Cicin-Sain, L.1
-
98
-
-
84869776196
-
Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life
-
Smithey, M. J., Li, G., Venturi, V., Davenport, M. P. and Nikolich-Zugich, J. Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life. J. Immunol. 189, 5356-5366 (2012).
-
(2012)
J. Immunol.
, vol.189
, pp. 5356-5366
-
-
Smithey, M.J.1
Li, G.2
Venturi, V.3
Davenport, M.P.4
Nikolich-Zugich, J.5
-
99
-
-
84866149968
-
Immune senescence: Relative contributions of age and cytomegalovirus infection
-
Mekker, A. et al. Immune senescence: relative contributions of age and cytomegalovirus infection. PLoS Pathog. 8, e1002850 (2012).
-
(2012)
PLoS Pathog.
, vol.8
, pp. e1002850
-
-
Mekker, A.1
-
100
-
-
84945957906
-
Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections
-
Marandu, T. F. et al. Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections. J. Virol. 89, 11715-11717 (2015).
-
(2015)
J. Virol.
, vol.89
, pp. 11715-11717
-
-
Marandu, T.F.1
-
101
-
-
34249005003
-
Herpesvirus latency confers symbiotic protection from bacterial infection
-
Barton, E. S. et al. Herpesvirus latency confers symbiotic protection from bacterial infection. Nature 447, 326-329 (2007).
-
(2007)
Nature
, vol.447
, pp. 326-329
-
-
Barton, E.S.1
-
102
-
-
84926442317
-
Cytomegalovirus infection enhances the immune response to influenza
-
Furman, D. et al. Cytomegalovirus infection enhances the immune response to influenza. Sci. Transl. Med. 7, 281ra43 (2015).
-
(2015)
Sci. Transl. Med.
, vol.7
, pp. 281ra43
-
-
Furman, D.1
-
103
-
-
85021779908
-
Recent advances in CMV tropism, latency, and diagnosis during aging
-
Leng, S. X. et al. Recent advances in CMV tropism, latency, and diagnosis during aging. Geroscience 39, 251-259 (2017).
-
(2017)
Geroscience
, vol.39
, pp. 251-259
-
-
Leng, S.X.1
-
104
-
-
84929870153
-
Geriatric syndromes in older HIV-infected adults
-
Greene, M. et al. Geriatric syndromes in older HIV-infected adults. J. Acquir. Immune Defic. Syndr. 69, 161-167 (2015).
-
(2015)
J. Acquir. Immune Defic. Syndr.
, vol.69
, pp. 161-167
-
-
Greene, M.1
-
105
-
-
84902246367
-
Is HIV a model of accelerated or accentuated aging?
-
Pathai, S., Bajillan, H., Landay, A. L. and High, K. P. Is HIV a model of accelerated or accentuated aging? J. Gerontol. A Biol. Sci. Med. Sci 69, 833-842 (2014).
-
(2014)
J. Gerontol. A Biol. Sci. Med. Sci
, vol.69
, pp. 833-842
-
-
Pathai, S.1
Bajillan, H.2
Landay, A.L.3
High, K.P.4
-
106
-
-
22744445281
-
Overview of caloric restriction and ageing
-
Masoro, E. J. Overview of caloric restriction and ageing. Mech. Ageing Dev. 126, 913-922 (2005).
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 913-922
-
-
Masoro, E.J.1
-
107
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison, D. E. et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392-395 (2009).
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
-
108
-
-
0032425810
-
Delayed immune aging in diet-restricted B6CBAT6 F1 mice is associated with preservation of naive T cells
-
Chen, J., Astle, C.M. and Harrison, D.E. Delayed immune aging in diet-restricted B6CBAT6 F1 mice is associated with preservation of naive T cells. Exp. Gerontol. 53A, B330-B337 (1998).
-
(1998)
Exp. Gerontol.
, vol.53 A
, pp. B330-B337
-
-
Chen, J.1
Astle, C.M.2
Harrison, D.E.3
-
109
-
-
33845898766
-
Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates
-
Messaoudi, I. et al. Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. Proc. Natl. Acad. Sci. USA 103, 19448-19453 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 19448-19453
-
-
Messaoudi, I.1
-
110
-
-
84924356420
-
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
-
Youm, Y. H. et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat. Med 21, 263-269 (2015).
-
(2015)
Nat. Med
, vol.21
, pp. 263-269
-
-
Youm, Y.H.1
-
112
-
-
84922636348
-
Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms
-
Goldberg, E. L. et al. Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms. Aging Cell 14, 130-138 (2015).
-
(2015)
Aging Cell
, vol.14
, pp. 130-138
-
-
Goldberg, E.L.1
-
113
-
-
84904264964
-
Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections
-
Goldberg, E. L., Smithey, M. J., Lutes, L. K., Uhrlaub, J. L. and NikolichZugich, J. Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections. J. Immunol. 193, 757-763 (2014).
-
(2014)
J. Immunol.
, vol.193
, pp. 757-763
-
-
Goldberg, E.L.1
Smithey, M.J.2
Lutes, L.K.3
Uhrlaub, J.L.4
Nikolichugich, J.5
-
114
-
-
84919756169
-
MTOR inhibition improves immune function in the elderly
-
Mannick, J. B. et al. mTOR inhibition improves immune function in the elderly. Sci. Transl. Med. 6, 268ra179 (2014).
-
(2014)
Sci. Transl. Med.
, vol.6
, pp. 268ra179
-
-
Mannick, J.B.1
|