Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus

PLoS Pathogens

Volumn 12, Issue 10, 2016, Pages

  Uhrlaub, Jennifer L ^a   Pulko, Vesna ^a,e   DeFilippis, Victor R ^b   Broeckel, Rebecca ^b   Streblow, Daniel N ^b   Coleman, Gary D ^c   Park, Byung S ^b   Lindo, John F ^d   Vickers, Ivan ^d   Anzinger, Joshua J ^d   Nikolich Žugich, Janko ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

^d UNIVERSITY OF THE WEST INDIES   (Jamaica)

^e Roche Glycart AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; NEUTRALIZING ANTIBODY; TRANSFORMING GROWTH FACTOR BETA; VIRUS ANTIBODY;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CHIKUNGUNYA; CHIKUNGUNYA VIRUS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; JOINT SWELLING; MALE; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRAL CLEARANCE; VIRAL PLAQUE ASSAY; ADULT; AGED; AGING; ANIMAL; BIOSYNTHESIS; BLOOD; C57BL MOUSE; DISEASE MODEL; DISEASE PREDISPOSITION; FEMALE; IMMUNOLOGY; POLYMERASE CHAIN REACTION;

ADULT; AGED; AGING; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CHIKUNGUNYA FEVER; CHIKUNGUNYA VIRUS; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MICE; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84992695872     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005891     Document Type: Article

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