Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists

Journal of Immunology

Volumn 199, Issue 4, 2017, Pages 1405-1417

  Metcalf, Talibah U ^a   Wilkinson, Peter A ^b   Cameron, Mark J ^b   Ghneim, Khader ^b   Chiang, Cindy ^c   Wertheimer, Anne M ^d   Hiscott, John B ^e   Nikolich Zugich, Janko ^d   Haddad, Elias K ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^e Pasteur Institute   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CYTOKINE; FC RECEPTOR; FCGR3B PROTEIN, HUMAN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; INTERFERON; PATTERN RECOGNITION RECEPTOR; TLR4 PROTEIN, HUMAN; TLR7 PROTEIN, HUMAN; TLR8 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8;

ADULT; AGED; AGING; AGONISTS; BIOSYNTHESIS; CLASSIFICATION; FEMALE; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; MALE; METABOLISM; MIDDLE AGED; MONOCYTE; PHYSIOLOGY; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANTIGENS, CD14; CYTOKINES; FEMALE; GENE EXPRESSION PROFILING; GPI-LINKED PROTEINS; HUMANS; IMMUNITY, INNATE; INTERFERONS; MALE; MIDDLE AGED; MONOCYTES; RECEPTORS, IGG; RECEPTORS, PATTERN RECOGNITION; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8; TRANSCRIPTION, GENETIC; YOUNG ADULT;

EID: 85027359896     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1700148     Document Type: Article

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