Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms

Aging Cell

Volumn 14, Issue 1, 2015, Pages 130-138

  Goldberg, Emily L ^a,b   Romero Aleshire, Melissa J ^c   Renkema, Kristin R ^a   Ventevogel, Melissa S ^d   Chew, Wade M ^e   Uhrlaub, Jennifer L ^a   Smithey, Megan J ^a   Limesand, Kirsten H ^b,e   Sempowski, Gregory D ^d   Brooks, Heddwen L ^c   Nikolich Žugich, Janko ^a,b,e  

^a UNIVERSITY OF ARIZONA   (United States)

^b Environmental Research Laboratory   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF ARIZONA   (United States)

Author keywords

Anti aging; Caloric restriction; Cellular immunology; Longevity regulation; Mouse models; T cell

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; MAMMALIAN TARGET OF RAPAMYCIN; TESTOSTERONE; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE;

ADAPTIVE IMMUNITY; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALORIC RESTRICTION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL AGING; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INHIBITION; FLAVIVIRUS INFECTION; HOST; IN VIVO STUDY; LIFESPAN; LYMPHOCYTE FUNCTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TESTOSTERONE BLOOD LEVEL; THYMUS; WEST NILE FLAVIVIRUS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; LONGEVITY; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; T LYMPHOCYTE; VIROLOGY; WEST NILE FEVER; WEST NILE VIRUS;

MUS; WEST NILE VIRUS;

ADAPTIVE IMMUNITY; ANIMALS; CALORIC RESTRICTION; LONGEVITY; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; MALE; MICE, INBRED C57BL; SIROLIMUS; T-LYMPHOCYTES; THYMUS GLAND; TOR SERINE-THREONINE KINASES; WEST NILE FEVER; WEST NILE VIRUS;

EID: 84922636348     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12280     Document Type: Article

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