Normalizing the environment recapitulates adult human immune traits in laboratory mice

Nature

Volumn 532, Issue 7600, 2016, Pages 512-516

  Beura, Lalit K ^a   Hamilton, Sara E ^a   Bi, Kevin ^b   Schenkel, Jason M ^a   Odumade, Oludare A ^a,d   Casey, Kerry A ^a   Thompson, Emily A ^a   Fraser, Kathryn A ^a,e   Rosato, Pamela C ^a   Filali Mouhim, Ali ^c   Sekaly, Rafick P ^c   Jenkins, Marc K ^a   Vezys, Vaiva ^a   Nicholas Haining, W ^b   Jameson, Stephen C ^a   Masopust, David ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d RADY CHILDREN'S HOSPITAL   (United States)

^e MEDIMMUNE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS AND CELL COMPONENTS; DISEASE INCIDENCE; ENVIRONMENTAL FACTOR; EXPERIMENTAL STUDY; GENE EXPRESSION; HYGIENE; IMMUNE RESPONSE; IMMUNE SYSTEM; INFECTIVITY; NEONATE; PHYSIOLOGICAL RESPONSE; RODENT;

ADAPTIVE IMMUNITY; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ENVIRONMENTAL CHANGE; EXPERIMENTAL MOUSE; HUMAN; IMMUNE SYSTEM; INNATE IMMUNITY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE SUBPOPULATION; MEMORY T LYMPHOCYTE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION; ANIMAL; ANIMAL HUSBANDRY; ANIMAL MODEL; CELL DIFFERENTIATION; COMPARATIVE STUDY; CYTOLOGY; ENVIRONMENT; ENVIRONMENTAL EXPOSURE; EXPERIMENTAL ANIMAL; FEMALE; GERMFREE ANIMAL; IMMUNITY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MALE; PHENOTYPE; PROCEDURES; T LYMPHOCYTE; VIROLOGY; WILD ANIMAL;

MUS;

ADULT; ANIMAL HUSBANDRY; ANIMALS; ANIMALS, LABORATORY; ANIMALS, WILD; CELL DIFFERENTIATION; ENVIRONMENT; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; IMMUNE SYSTEM; IMMUNITY; IMMUNITY, INNATE; IMMUNOLOGIC MEMORY; INFANT, NEWBORN; MALE; MICE; MODELS, ANIMAL; PHENOTYPE; SPECIFIC PATHOGEN-FREE ORGANISMS; T-LYMPHOCYTES; VIRUS DISEASES;

EID: 84964918435     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature17655     Document Type: Article

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