Associations of heart rate with inflammatory markers are modulated by gender and obesity in older adults

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 70, Issue 7, 2015, Pages 899-904

  Laudisio, Alice ^a   Bandinelli, Stefania ^b   Gemma, Antonella ^c   Ferrucci, Luigi ^d   Incalzi, Raffaele Antonelli ^a  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

^c Azienda Sanitaria Locale Roma E ^*  (Italy)

^d NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Body mass index; Elderly; Epidemiology; Heart rate; Inflammation

Indexed keywords

BIOLOGICAL MARKER; HYDROCORTISONE; INTERLEUKIN 6;

AGE; AGED; BLOOD; BODY MASS; COHORT ANALYSIS; COMPLICATION; FEMALE; HEART RATE; HUMAN; ITALY; MALE; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; SEX DIFFERENCE; VERY ELDERLY;

AGE FACTORS; AGED; AGED, 80 AND OVER; BIOMARKERS; BODY MASS INDEX; COHORT STUDIES; FEMALE; HEART RATE; HUMANS; HYDROCORTISONE; INTERLEUKIN-6; ITALY; MALE; OBESITY; SEX FACTORS;

EID: 84936769983     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glu211     Document Type: Article

References (29)

1. Thomas F, Bean K, Provost JC, Guize L, Benetos A. Combined effects of heart rate and pulse pressure on cardiovascular mortality according to age. J Hypertens. 2001; 19: 863-869
2. Heidland UE, Strauer BE. Left ventricular muscle mass and elevated heart rate are associated with coronary plaque disruption. Circulation. 2001; 104: 1477-1482
3. Kado DM, Lui LL, Cummings SR. Rapid resting heart rate: a simple and powerful predictor of osteoporotic fractures and mortality in older women. J Am Ger SoC 2002; 50: 455-60
4. Piha SJ, Voipio-Pulkki LM. Elevated resting heart rate in rheumatoid arthritis: possible role of physical deconditioning. Br J Rheumatol. 1993; 32: 212-215
5. Cesari M, Penninx BW, Newman AB, et al. Inflammatory markers and onset of cardiovascular events: results from the Health ABC study. Circulation. 2003; 108: 2317-2322
6. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002; 105: 1135-1143
7. Harris TB, Ferrucci L, Tracy RP, et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 1999; 106: 506-512
8. Reuben DB, Cheh AI, Harris TB, et al. Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons. J Am Geriatr SoC 2002; 50: 638-644
9. Oddis CV, Finkel MS. Cytokines and nitric oxide synthase inhibitor as mediators of adrenergic refractoriness in cardiac myocytes. Eur J Pharmacol. 1997; 320: 167-174
10. Torpy DJ, Papanicolaou DA, Lotsikas AJ, Wilder RL, Chrousos GP, Pillemer SR. Responses of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis to interleukin-6: a pilot study in fibromyalgia. Arthritis Rheum. 2000; 43: 872-880
11. Whitworth JA, Williamson PM, Mangos G, Kelly JJ. Cardiovascular consequences of cortisol excess. Vasc Health Risk Manag. 2005; 1: 291-299
12. Beleigoli AM, Boersma E, Diniz Mde F, Lima-Costa MF, Ribeiro AL. Overweight and class I obesity are associated with lower 10-year risk of mortality in Brazilian older adults: the Bambui Cohort Study of Ageing. PLoS One. 2012; 7: e52111
13. Ferrucci L, Bandinelli S, Benvenuti E, et al. Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study. J Am Geriatr SoC 2000; 48: 1618-1625
14. Guralnik JM, Fried LP, Simonsick EM, Kasper JD, Lafferty ME. The Women's Health and Aging Study. Health and social characteristics of older women with disability. Bethesda, 1995 MD: National Institute on Aging
15. WHO Collaborating Centre for Drug Statistics Methodology. ATC/DDD Methodology: History. Retrieved from www.whocc.no/atc-ddd- methodology/who-collaborating-centre
16. Pisani P, Faggiano F, Krogh V, Palli D, Vineis P, Berrino F. Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC centres. Int J Epidemiol. 1997; 26(Suppl 1): S152-S160
17. National Institute on Aging. Retrieved from www.grc.nia.nih.gov/branches/leps/sppb
18. Fisher G, Hunter GR, Glasser SP. Associations between arterial elasticity and markers of inflammation in healthy older women. J Gerontol A Biol Sci Med Sci. 2013; 68: 382-388
19. Stessman J, Jacobs JM, Stessman-Lande I, Gilon D, Leibowitz D. Aging, resting pulse rate, and longevity. J Am Geriatr SoC 2013; 61: 40-45
20. Critchley WR, Yonan N, Shaw SM, Fildes JE. Heart rate after cardiac transplantation-lessons from the tortoise and the shrew. Transplantation. 2013; 95: 259-265
21. Pittaras AM, Faselis C, Doumas M, et al. Heart rate at rest, exercise capacity, and mortality risk in veterans. Am J Cardiol. 2013; 112: 1605-1609
22. Deng MC, Erren M, Kammerling L, et al. The relation of interleukin-6, tumor necrosis factor-alpha, IL-2, and IL-2 receptor levels to cellular rejection, allograft dysfunction, and clinical events early after cardiac transplantation. Transplantation. 1995; 60: 1118-1124
23. Pearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003; 107: 499-511
24. Varadhan R, Chaves PH, Lipsitz LA, et al. Frailty and impaired cardiac autonomic control: new insights from principal components aggregation of traditional heart rate variability indices. J Gerontol A Biol Sci Med Sci. 2009; 64: 682-687
25. Lampert R, Bremner JD, Su S, et al. Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men. Am Heart J. 2008; 156: 759.e1-759.e7
26. Bastard JP, Maachi M, Lagathu C, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006; 17: 4-12
27. Lieb DC, Parson HK, Mamikunian G, Vinik AI. Cardiac autonomic imbalance in newly diagnosed and established diabetes is associated with markers of adipose tissue inflammation. Exp Diabetes Res. 2012; 2012: 878760
28. Hubbard RE, Lang IA, Llewellyn DJ, Rockwood K. Frailty, body mass index, and abdominal obesity in older people. J Gerontol A Biol Sci Med Sci. 2010; 65: 377-381
29. Gopal Krushna P, Chandrasekaran A, Palghat Hariharan A, et al.Sympathovagal Imbalance Contributes to Prehypertension Status and Cardiovascular Risks Attributed by Insulin Resistance, Inflammation, Dyslipidemia and Oxidative Stress in First Degree Relatives of Type 2 Diabetics. PLoS One. 2013; 8(11): e78072