Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections

Journal of Immunology

Volumn 193, Issue 2, 2014, Pages 757-763

  Goldberg, Emily L ^a,b   Smithey, Megan J ^a   Lutes, Lydia K ^a,c   Uhrlaub, Jennifer L ^a   Nikolich Žugich, Janko ^a,b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b Environmental Research Laboratory   (United States)

^c University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM IONOPHORE; PHORBOL ESTER; RAPAMYCIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL LOAD; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; GLYCOLYSIS; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOLOGICAL MEMORY; IMMUNOLOGICAL PARAMETERS; IN VITRO STUDY; IN VIVO STUDY; LIFE EXTENSION; LISTERIOSIS; LOW DRUG DOSE; LYMPHOCYTE FUNCTION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MACROPHAGE FUNCTION; MACROPHAGE VESICLE ACIDIFICATION; MALE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS LOAD; WEST NILE FEVER;

ADULT; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GLYCOLYSIS; GRANZYMES; HOST-PATHOGEN INTERACTIONS; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOLOGIC MEMORY; IMMUNOSUPPRESSIVE AGENTS; INTERFERON-GAMMA; LISTERIA MONOCYTOGENES; LISTERIOSIS; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; LYSOSOMES; MACROPHAGES; MICE; MICE, INBRED C57BL; SIROLIMUS; T-LYMPHOCYTE SUBSETS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84904264964     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400188     Document Type: Article

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