메뉴 건너뛰기




Volumn 18, Issue 12, 2017, Pages 758-770

Mechanobiology of YAP and TAZ in physiology and disease

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE 1; INTEGRIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TAZ; TRANSCRIPTION FACTOR YAP; UNCLASSIFIED DRUG; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TAZ PROTEIN, HUMAN; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

EID: 85034578849     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm.2017.87     Document Type: Review
Times cited : (910)

References (135)
  • 1
    • 58849106652 scopus 로고    scopus 로고
    • A tense situation: Forcing tumour progression
    • Butcher, D. T., Alliston, T. & Weaver, V. M. A tense situation: forcing tumour progression. Nat. Rev. Cancer 9, 108-122 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 108-122
    • Butcher, D.T.1    Alliston, T.2    Weaver, V.M.3
  • 2
    • 67649920749 scopus 로고    scopus 로고
    • Growth factors, matrices, and forces combine and control stem cells
    • Discher, D. E., Mooney, D. J. & Zandstra, P. W. Growth factors, matrices, and forces combine and control stem cells. Science 324, 1673-1677 (2009).
    • (2009) Science , vol.324 , pp. 1673-1677
    • Discher, D.E.1    Mooney, D.J.2    Zandstra, P.W.3
  • 3
    • 58049213928 scopus 로고    scopus 로고
    • Mechanotransduction in vascular physiology and atherogenesis
    • Hahn, C. & Schwartz, M. A. Mechanotransduction in vascular physiology and atherogenesis. Nat. Rev. Mol. Cell Biol. 10, 53-62 (2009).
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 53-62
    • Hahn, C.1    Schwartz, M.A.2
  • 5
    • 70549098542 scopus 로고    scopus 로고
    • Cytoskeletal control of growth and cell fate switching
    • Mammoto, A. & Ingber, D. E. Cytoskeletal control of growth and cell fate switching. Curr. Opin. Cell Biol. 21, 864-870 (2009).
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 864-870
    • Mammoto, A.1    Ingber, D.E.2
  • 6
    • 79953148385 scopus 로고    scopus 로고
    • Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling
    • Provenzano, P. P. & Keely, P. J. Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling. J. Cell Sci. 124, 1195-1205 (2011).
    • (2011) J. Cell Sci. , vol.124 , pp. 1195-1205
    • Provenzano, P.P.1    Keely, P.J.2
  • 7
    • 33645773666 scopus 로고    scopus 로고
    • Local force and geometry sensing regulate cell functions
    • Vogel, V. & Sheetz, M. Local force and geometry sensing regulate cell functions. Nat. Rev. Mol. Cell Biol. 7, 265-275 (2006).
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 265-275
    • Vogel, V.1    Sheetz, M.2
  • 8
    • 58049220350 scopus 로고    scopus 로고
    • Mechanotransduction in development: A growing role for contractility
    • Wozniak, M. A. & Chen, C. S. Mechanotransduction in development: a growing role for contractility. Nat. Rev. Mol. Cell Biol. 10, 34-43 (2009).
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 34-43
    • Wozniak, M.A.1    Chen, C.S.2
  • 9
    • 84867317839 scopus 로고    scopus 로고
    • Developmental biology. Physical biology returns to morphogenesis
    • Keller, R. Developmental biology. Physical biology returns to morphogenesis. Science 338, 201-203 (2012).
    • (2012) Science , vol.338 , pp. 201-203
    • Keller, R.1
  • 11
    • 33747152561 scopus 로고    scopus 로고
    • Matrix elasticity directs stem cell lineage specification
    • Engler, A. J., Sen, S., Sweeney, H. L. & Discher, D. E. Matrix elasticity directs stem cell lineage specification. Cell 126, 677-689 (2006).
    • (2006) Cell , vol.126 , pp. 677-689
    • Engler, A.J.1    Sen, S.2    Sweeney, H.L.3    Discher, D.E.4
  • 12
    • 0018140371 scopus 로고
    • Role of cell shape in growth control
    • Folkman, J. & Moscona, A. Role of cell shape in growth control. Nature 273, 345-349 (1978).
    • (1978) Nature , vol.273 , pp. 345-349
    • Folkman, J.1    Moscona, A.2
  • 13
    • 2642666080 scopus 로고
    • Cell shape controls terminal differentiation of human epidermal keratinocytes
    • Watt, F. M., Jordan, P. W. & O'Neill, C. H. Cell shape controls terminal differentiation of human epidermal keratinocytes. Proc. Natl Acad. Sci. USA 85, 5576-5580 (1988).
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 5576-5580
    • Watt, F.M.1    Jordan, P.W.2    O'Neill, C.H.3
  • 14
    • 84940587069 scopus 로고    scopus 로고
    • Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
    • Zanconato, F. et al. Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth. Nat. Cell Biol. 17, 1218-1227 (2015).
    • (2015) Nat. Cell Biol. , vol.17 , pp. 1218-1227
    • Zanconato, F.1
  • 15
    • 84944897345 scopus 로고    scopus 로고
    • YAP drives growth by controlling transcriptional pause release from dynamic enhancers
    • Galli, G. G. et al. YAP drives growth by controlling transcriptional pause release from dynamic enhancers. Mol. Cell 60, 328-337 (2015).
    • (2015) Mol. Cell , vol.60 , pp. 328-337
    • Galli, G.G.1
  • 16
    • 84940742233 scopus 로고    scopus 로고
    • YAP1 exerts its transcriptional control via TEAD-mediated activation of enhancers
    • Stein, C. et al. YAP1 exerts its transcriptional control via TEAD-mediated activation of enhancers. PLoS Genet. 11, e1005465 (2015).
    • (2015) PLoS Genet. , vol.11 , pp. e1005465
    • Stein, C.1
  • 17
    • 0035873391 scopus 로고    scopus 로고
    • TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm
    • Vassilev, A., Kaneko, K. J., Shu, H., Zhao, Y. & DePamphilis, M. L. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev. 15, 1229-1241 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 1229-1241
    • Vassilev, A.1    Kaneko, K.J.2    Shu, H.3    Zhao, Y.4    DePamphilis, M.L.5
  • 18
    • 23744458034 scopus 로고    scopus 로고
    • The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP
    • Huang, J., Wu, S., Barrera, J., Matthews, K. & Pan, D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP. Cell 122, 421-434 (2005).
    • (2005) Cell , vol.122 , pp. 421-434
    • Huang, J.1    Wu, S.2    Barrera, J.3    Matthews, K.4    Pan, D.5
  • 19
    • 42049116586 scopus 로고    scopus 로고
    • The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway
    • Wu, S., Liu, Y., Zheng, Y., Dong, J. & Pan, D. The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Dev. Cell 14, 388-398 (2008).
    • (2008) Dev. Cell , vol.14 , pp. 388-398
    • Wu, S.1    Liu, Y.2    Zheng, Y.3    Dong, J.4    Pan, D.5
  • 20
    • 77957883342 scopus 로고    scopus 로고
    • The Hippo signaling pathway in development and cancer
    • Pan, D. The Hippo signaling pathway in development and cancer. Dev. Cell 19, 491-505 (2010).
    • (2010) Dev. Cell , vol.19 , pp. 491-505
    • Pan, D.1
  • 21
    • 84947725512 scopus 로고    scopus 로고
    • Hippo pathway in organ size control, tissue homeostasis, and cancer
    • Yu, F. X., Zhao, B. & Guan, K. L. Hippo pathway in organ size control, tissue homeostasis, and cancer. Cell 163, 811-828 (2015).
    • (2015) Cell , vol.163 , pp. 811-828
    • Yu, F.X.1    Zhao, B.2    Guan, K.L.3
  • 22
    • 84916633921 scopus 로고    scopus 로고
    • The biology of YAP/TAZ: Hippo signaling and beyond
    • Piccolo, S., Dupont, S. & Cordenonsi, M. The biology of YAP/TAZ: hippo signaling and beyond. Physiol. Rev. 94, 1287-1312 (2014).
    • (2014) Physiol. Rev. , vol.94 , pp. 1287-1312
    • Piccolo, S.1    Dupont, S.2    Cordenonsi, M.3
  • 23
    • 84907556031 scopus 로고    scopus 로고
    • Sensing the local environment: Actin architecture and Hippo signalling
    • Gaspar, P. & Tapon, N. Sensing the local environment: actin architecture and Hippo signalling. Curr. Opin. Cell Biol. 31, 74-83 (2014).
    • (2014) Curr. Opin. Cell Biol. , vol.31 , pp. 74-83
    • Gaspar, P.1    Tapon, N.2
  • 24
    • 84883466306 scopus 로고    scopus 로고
    • A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors
    • Aragona, M. et al. A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. Cell 154, 1047-1059 (2013).
    • (2013) Cell , vol.154 , pp. 1047-1059
    • Aragona, M.1
  • 25
    • 85010383227 scopus 로고    scopus 로고
    • Glucocorticoid receptor signalling activates YAP in breast cancer
    • Sorrentino, G. et al. Glucocorticoid receptor signalling activates YAP in breast cancer. Nat. Commun. 8, 14073 (2017).
    • (2017) Nat. Commun. , vol.8 , pp. 14073
    • Sorrentino, G.1
  • 26
    • 84964744532 scopus 로고    scopus 로고
    • YAP nuclear localization in the absence of cell-cell contact is mediated by a filamentous actin-dependent, myosin II-and phospho-YAP-independent pathway during extracellular matrix mechanosensing
    • Das, A., Fischer, R. S., Pan, D. & Waterman, C. M. YAP nuclear localization in the absence of cell-cell contact is mediated by a filamentous actin-dependent, myosin II-and phospho-YAP-independent pathway during extracellular matrix mechanosensing. J. Biol. Chem. 291, 6096-6110 (2016).
    • (2016) J. Biol. Chem. , vol.291 , pp. 6096-6110
    • Das, A.1    Fischer, R.S.2    Pan, D.3    Waterman, C.M.4
  • 27
    • 79958284636 scopus 로고    scopus 로고
    • Role of YAP/TAZ in mechanotransduction
    • Dupont, S. et al. Role of YAP/TAZ in mechanotransduction. Nature 474, 179-183 (2011).
    • (2011) Nature , vol.474 , pp. 179-183
    • Dupont, S.1
  • 28
    • 85018187888 scopus 로고    scopus 로고
    • An FAK-YAP-mTOR signaling axis regulates stem cell-based tissue renewal in mice
    • Hu, J. K. et al. An FAK-YAP-mTOR signaling axis regulates stem cell-based tissue renewal in mice. Cell Stem Cell 21, 91-106 (2017).
    • (2017) Cell Stem Cell , vol.21 , pp. 91-106
    • Hu, J.K.1
  • 29
    • 84905101429 scopus 로고    scopus 로고
    • YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth
    • Low, B. C. et al. YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth. FEBS Lett. 588, 2663-2670 (2014).
    • (2014) FEBS Lett. , vol.588 , pp. 2663-2670
    • Low, B.C.1
  • 30
    • 84875973770 scopus 로고    scopus 로고
    • Yap-and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development
    • Reginensi, A. et al. Yap-and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development. PLoS Genet. 9, e1003380 (2013).
    • (2013) PLoS Genet. , vol.9 , pp. e1003380
    • Reginensi, A.1
  • 31
    • 84902482143 scopus 로고    scopus 로고
    • Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry
    • Feng, X. et al. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell 25, 831-845 (2014).
    • (2014) Cancer Cell , vol.25 , pp. 831-845
    • Feng, X.1
  • 32
    • 84897579255 scopus 로고    scopus 로고
    • Metabolic control of YAP and TAZ by the mevalonate pathway
    • Sorrentino, G. et al. Metabolic control of YAP and TAZ by the mevalonate pathway. Nat. Cell Biol. 16, 357-366 (2014).
    • (2014) Nat. Cell Biol. , vol.16 , pp. 357-366
    • Sorrentino, G.1
  • 33
    • 84924328294 scopus 로고    scopus 로고
    • A gp130-Src-YAP module links inflammation to epithelial regeneration
    • Taniguchi, K. et al. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature 519, 57-62 (2015).
    • (2015) Nature , vol.519 , pp. 57-62
    • Taniguchi, K.1
  • 34
    • 80051923057 scopus 로고    scopus 로고
    • Hippo pathway regulation by cell morphology and stress fibers
    • Wada, K., Itoga, K., Okano, T., Yonemura, S. & Sasaki, H. Hippo pathway regulation by cell morphology and stress fibers. Development 138, 3907-3914 (2011).
    • (2011) Development , vol.138 , pp. 3907-3914
    • Wada, K.1    Itoga, K.2    Okano, T.3    Yonemura, S.4    Sasaki, H.5
  • 35
    • 84891940884 scopus 로고    scopus 로고
    • Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility
    • Wang, Z. et al. Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proc. Natl Acad. Sci. USA 111, E89-E98 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. E89-E98
    • Wang, Z.1
  • 36
    • 84878615570 scopus 로고    scopus 로고
    • Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
    • Calvo, F. et al. Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. Nat. Cell Biol. 15, 637-646 (2013).
    • (2013) Nat. Cell Biol. , vol.15 , pp. 637-646
    • Calvo, F.1
  • 37
    • 79956327002 scopus 로고    scopus 로고
    • Actin-capping protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila
    • Fernandez, B. G. et al. Actin-capping protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. Development 138, 2337-2346 (2011).
    • (2011) Development , vol.138 , pp. 2337-2346
    • Fernandez, B.G.1
  • 38
    • 84865411430 scopus 로고    scopus 로고
    • Transduction of mechanical and cytoskeletal cues by YAP and TAZ
    • Halder, G., Dupont, S. & Piccolo, S. Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat. Rev. Mol. Cell Biol. 13, 591-600 (2012).
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 591-600
    • Halder, G.1    Dupont, S.2    Piccolo, S.3
  • 39
    • 84866621806 scopus 로고    scopus 로고
    • Regulation of the Hippo pathway by cell architecture and mechanical signals
    • Schroeder, M. C. & Halder, G. Regulation of the Hippo pathway by cell architecture and mechanical signals. Semin. Cell Dev. Biol. 23, 803-811 (2012).
    • (2012) Semin. Cell Dev. Biol. , vol.23 , pp. 803-811
    • Schroeder, M.C.1    Halder, G.2
  • 40
    • 84991502908 scopus 로고    scopus 로고
    • Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis
    • Wang, K. C. et al. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc. Natl Acad. Sci. USA 113, 11525-11530 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. 11525-11530
    • Wang, K.C.1
  • 41
    • 85008231121 scopus 로고    scopus 로고
    • Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow
    • Wang, L. et al. Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature 540, 579-582 (2016).
    • (2016) Nature , vol.540 , pp. 579-582
    • Wang, L.1
  • 42
    • 85016450607 scopus 로고    scopus 로고
    • Flow-dependent endothelial YAP regulation contributes to vessel maintenance
    • Nakajima, H. et al. Flow-dependent endothelial YAP regulation contributes to vessel maintenance. Dev. Cell 40, 523-536 (2017).
    • (2017) Dev. Cell , vol.40 , pp. 523-536
    • Nakajima, H.1
  • 43
    • 85019950835 scopus 로고    scopus 로고
    • YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate
    • Totaro, A. et al. YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate. Nat. Commun. 8, 15206 (2017).
    • (2017) Nat. Commun. , vol.8 , pp. 15206
    • Totaro, A.1
  • 44
    • 84930678799 scopus 로고    scopus 로고
    • Cell adhesion. Mechanical strain induces E-cadherin-dependent Yap1 and beta-catenin activation to drive cell cycle entry
    • Benham-Pyle, B. W., Pruitt, B. L. & Nelson, W. J. Cell adhesion. Mechanical strain induces E-cadherin-dependent Yap1 and beta-catenin activation to drive cell cycle entry. Science 348, 1024-1027 (2015).
    • (2015) Science , vol.348 , pp. 1024-1027
    • Benham-Pyle, B.W.1    Pruitt, B.L.2    Nelson, W.J.3
  • 45
    • 85016162669 scopus 로고    scopus 로고
    • Designer matrices for intestinal stem cell and organoid culture
    • Gjorevski, N. et al. Designer matrices for intestinal stem cell and organoid culture. Nature 539, 560-564 (2016).
    • (2016) Nature , vol.539 , pp. 560-564
    • Gjorevski, N.1
  • 46
    • 79960277917 scopus 로고    scopus 로고
    • A hitchhiker's guide to mechanobiology
    • Eyckmans, J., Boudou, T., Yu, X. & Chen, C. S. A hitchhiker's guide to mechanobiology. Dev. Cell 21, 35-47 (2011).
    • (2011) Dev. Cell , vol.21 , pp. 35-47
    • Eyckmans, J.1    Boudou, T.2    Yu, X.3    Chen, C.S.4
  • 47
    • 84855326431 scopus 로고    scopus 로고
    • Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis
    • Zhao, B. et al. Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev. 26, 54-68 (2012).
    • (2012) Genes Dev. , vol.26 , pp. 54-68
    • Zhao, B.1
  • 48
    • 77954243855 scopus 로고    scopus 로고
    • Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions
    • Connelly, J. T. et al. Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat. Cell Biol. 12, 711-718 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , pp. 711-718
    • Connelly, J.T.1
  • 49
    • 79958851169 scopus 로고    scopus 로고
    • Modulating F-actin organization induces organ growth by affecting the Hippo pathway
    • Sansores-Garcia, L. et al. Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J. 30, 2325-2335 (2011).
    • (2011) EMBO J. , vol.30 , pp. 2325-2335
    • Sansores-Garcia, L.1
  • 50
    • 84901236414 scopus 로고    scopus 로고
    • Angiomotins link F-actin architecture to Hippo pathway signaling
    • Mana-Capelli, S., Paramasivam, M., Dutta, S. & McCollum, D. Angiomotins link F-actin architecture to Hippo pathway signaling. Mol. Biol. Cell 25, 1676-1685 (2014).
    • (2014) Mol. Biol. Cell , vol.25 , pp. 1676-1685
    • Mana-Capelli, S.1    Paramasivam, M.2    Dutta, S.3    McCollum, D.4
  • 51
    • 85018901340 scopus 로고    scopus 로고
    • Regulation of localization and function of the transcriptional co-activator YAP by angiomotin
    • Moleirinho, S. et al. Regulation of localization and function of the transcriptional co-activator YAP by angiomotin. eLife 6, e23966 (2017).
    • (2017) ELife , vol.6 , pp. e23966
    • Moleirinho, S.1
  • 52
    • 84926338403 scopus 로고    scopus 로고
    • Spectrin regulates Hippo signaling by modulating cortical actomyosin activity
    • Deng, H. et al. Spectrin regulates Hippo signaling by modulating cortical actomyosin activity. eLife 4, e06567 (2015).
    • (2015) ELife , vol.4 , pp. e06567
    • Deng, H.1
  • 53
    • 84926258240 scopus 로고    scopus 로고
    • The Spectrin cytoskeleton regulates the Hippo signalling pathway
    • Fletcher, G. C. et al. The Spectrin cytoskeleton regulates the Hippo signalling pathway. EMBO J. 34, 940-954 (2015).
    • (2015) EMBO J. , vol.34 , pp. 940-954
    • Fletcher, G.C.1
  • 54
    • 78649892579 scopus 로고    scopus 로고
    • Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling
    • Oka, T. et al. Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling. Biochem. J. 432, 461-472 (2010).
    • (2010) Biochem. J. , vol.432 , pp. 461-472
    • Oka, T.1
  • 55
    • 84865342852 scopus 로고    scopus 로고
    • Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling
    • Pan, C. Q., Sudol, M., Sheetz, M. & Low, B. C. Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling. Cell. Signal. 24, 2143-2165 (2012).
    • (2012) Cell. Signal. , vol.24 , pp. 2143-2165
    • Pan, C.Q.1    Sudol, M.2    Sheetz, M.3    Low, B.C.4
  • 56
    • 77957131890 scopus 로고    scopus 로고
    • TAZ interacts with zonula occludens-1 and-2 proteins in a PDZ-1 dependent manner
    • Remue, E. et al. TAZ interacts with zonula occludens-1 and-2 proteins in a PDZ-1 dependent manner. FEBS Lett. 584, 4175-4180 (2010).
    • (2010) FEBS Lett. , vol.584 , pp. 4175-4180
    • Remue, E.1
  • 57
    • 79952298459 scopus 로고    scopus 로고
    • Yap1 acts downstream of alpha-catenin to control epidermal proliferation
    • Schlegelmilch, K. et al. Yap1 acts downstream of alpha-catenin to control epidermal proliferation. Cell 144, 782-795 (2011).
    • (2011) Cell , vol.144 , pp. 782-795
    • Schlegelmilch, K.1
  • 58
    • 79957462240 scopus 로고    scopus 로고
    • α-Catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1
    • Silvis, M. R. et al. α-Catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1. Sci. Signal. 4, ra33 (2011).
    • (2011) Sci. Signal. , vol.4 , pp. ra33
    • Silvis, M.R.1
  • 60
    • 84922322060 scopus 로고    scopus 로고
    • Appreciating force and shape-the rise of mechanotransduction in cell biology
    • Iskratsch, T., Wolfenson, H. & Sheetz, M. P. Appreciating force and shape-the rise of mechanotransduction in cell biology. Nat. Rev. Mol. Cell Biol. 15, 825-833 (2014).
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 825-833
    • Iskratsch, T.1    Wolfenson, H.2    Sheetz, M.P.3
  • 61
    • 84905101429 scopus 로고    scopus 로고
    • YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth
    • Low, B. C. et al. YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth. FEBS Lett. 588, 2663-2670 (2014).
    • (2014) FEBS Lett. , vol.588 , pp. 2663-2670
    • Low, B.C.1
  • 62
    • 0037175402 scopus 로고    scopus 로고
    • The relationship between force and focal complex development
    • Galbraith, C. G., Yamada, K. M. & Sheetz, M. P. The relationship between force and focal complex development. J. Cell Biol. 159, 695-705 (2002).
    • (2002) J. Cell Biol. , vol.159 , pp. 695-705
    • Galbraith, C.G.1    Yamada, K.M.2    Sheetz, M.P.3
  • 63
    • 0035801529 scopus 로고    scopus 로고
    • Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment
    • Tzima, E., del Pozo, M. A., Shattil, S. J., Chien, S. & Schwartz, M. A. Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment. EMBO J. 20, 4639-4647 (2001).
    • (2001) EMBO J. , vol.20 , pp. 4639-4647
    • Tzima, E.1    Del Pozo, M.A.2    Shattil, S.J.3    Chien, S.4    Schwartz, M.A.5
  • 64
    • 84904043132 scopus 로고    scopus 로고
    • YAP/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt response
    • Azzolin, L. et al. YAP/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt response. Cell 158, 157-170 (2014).
    • (2014) Cell , vol.158 , pp. 157-170
    • Azzolin, L.1
  • 65
    • 84994728929 scopus 로고    scopus 로고
    • Induction of expandable tissue-specific stem/progenitor cells through transient expression of YAP/TAZ
    • Panciera, T. et al. Induction of expandable tissue-specific stem/progenitor cells through transient expression of YAP/TAZ. Cell Stem Cell 19, 725-737 (2016).
    • (2016) Cell Stem Cell , vol.19 , pp. 725-737
    • Panciera, T.1
  • 67
    • 84947465984 scopus 로고    scopus 로고
    • ADF and cofilin1 control actin stress fibers, nuclear integrity, and cell survival
    • Kanellos, G. et al. ADF and cofilin1 control actin stress fibers, nuclear integrity, and cell survival. Cell Rep. 13, 1949-1964 (2015).
    • (2015) Cell Rep. , vol.13 , pp. 1949-1964
    • Kanellos, G.1
  • 68
    • 61749092595 scopus 로고    scopus 로고
    • The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass
    • Nishioka, N. et al. The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev. Cell 16, 398-410 (2009).
    • (2009) Dev. Cell , vol.16 , pp. 398-410
    • Nishioka, N.1
  • 69
    • 84910147298 scopus 로고    scopus 로고
    • Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst
    • Kono, K., Tamashiro, D. A. & Alarcon, V. B. Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst. Dev. Biol. 394, 142-155 (2014).
    • (2014) Dev. Biol. , vol.394 , pp. 142-155
    • Kono, K.1    Tamashiro, D.A.2    Alarcon, V.B.3
  • 70
    • 84983282222 scopus 로고    scopus 로고
    • Asymmetric division of contractile domains couples cell positioning and fate specification
    • Maitre, J. L. et al. Asymmetric division of contractile domains couples cell positioning and fate specification. Nature 536, 344-348 (2016).
    • (2016) Nature , vol.536 , pp. 344-348
    • Maitre, J.L.1
  • 71
    • 84952628235 scopus 로고    scopus 로고
    • Rho-signaling-directed YAP/TAZ activity underlies the long-term survival and expansion of human embryonic stem cells
    • Ohgushi, M., Minaguchi, M. & Sasai, Y. Rho-signaling-directed YAP/TAZ activity underlies the long-term survival and expansion of human embryonic stem cells. Cell Stem Cell 17, 448-461 (2015).
    • (2015) Cell Stem Cell , vol.17 , pp. 448-461
    • Ohgushi, M.1    Minaguchi, M.2    Sasai, Y.3
  • 72
    • 84907222899 scopus 로고    scopus 로고
    • Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification
    • Musah, S. et al. Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification. Proc. Natl Acad. Sci. USA 111, 13805-13810 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 13805-13810
    • Musah, S.1
  • 73
    • 84891012505 scopus 로고    scopus 로고
    • Switch enhancers interpret TGF-beta and Hippo signaling to control cell fate in human embryonic stem cells
    • Beyer, T. A. et al. Switch enhancers interpret TGF-beta and Hippo signaling to control cell fate in human embryonic stem cells. Cell Rep. 5, 1611-1624 (2013).
    • (2013) Cell Rep. , vol.5 , pp. 1611-1624
    • Beyer, T.A.1
  • 74
    • 84870401897 scopus 로고    scopus 로고
    • Glycosaminoglycan-binding hydrogels enable mechanical control of human pluripotent stem cell self-renewal
    • Musah, S. et al. Glycosaminoglycan-binding hydrogels enable mechanical control of human pluripotent stem cell self-renewal. ACS Nano 6, 10168-10177 (2012).
    • (2012) ACS Nano , vol.6 , pp. 10168-10177
    • Musah, S.1
  • 75
    • 84975780433 scopus 로고    scopus 로고
    • Human pluripotent stem cell culture density modulates YAP signaling
    • Hsiao, C. et al. Human pluripotent stem cell culture density modulates YAP signaling. Biotechnol. J. 11, 662-675 (2016).
    • (2016) Biotechnol. J. , vol.11 , pp. 662-675
    • Hsiao, C.1
  • 76
    • 84901241149 scopus 로고    scopus 로고
    • Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells
    • Sun, Y. et al. Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells. Nat. Mater. 13, 599-604 (2014).
    • (2014) Nat. Mater. , vol.13 , pp. 599-604
    • Sun, Y.1
  • 77
    • 1842426730 scopus 로고    scopus 로고
    • Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment
    • McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K. & Chen, C. S. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev. Cell 6, 483-495 (2004).
    • (2004) Dev. Cell , vol.6 , pp. 483-495
    • McBeath, R.1    Pirone, D.M.2    Nelson, C.M.3    Bhadriraju, K.4    Chen, C.S.5
  • 78
    • 23644431709 scopus 로고    scopus 로고
    • TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
    • Hong, J. H. et al. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309, 1074-1078 (2005).
    • (2005) Science , vol.309 , pp. 1074-1078
    • Hong, J.H.1
  • 79
    • 84980383772 scopus 로고    scopus 로고
    • Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation
    • Tang, Y., Feinberg, T., Keller, E. T., Li, X. Y. & Weiss, S. J. Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation. Nat. Cell Biol. 18, 917-929 (2016).
    • (2016) Nat. Cell Biol. , vol.18 , pp. 917-929
    • Tang, Y.1    Feinberg, T.2    Keller, E.T.3    Li, X.Y.4    Weiss, S.J.5
  • 80
    • 84878368948 scopus 로고    scopus 로고
    • MT1-MMP-dependent control of skeletal stem cell commitment via a beta1-integrin/YAP/TAZ signaling axis
    • Tang, Y. et al. MT1-MMP-dependent control of skeletal stem cell commitment via a beta1-integrin/YAP/TAZ signaling axis. Dev. Cell 25, 402-416 (2013).
    • (2013) Dev. Cell , vol.25 , pp. 402-416
    • Tang, Y.1
  • 81
    • 84982107171 scopus 로고    scopus 로고
    • N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells
    • Cosgrove, B. D. et al. N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells. Nat. Mater. 15, 1297-1306 (2016).
    • (2016) Nat. Mater. , vol.15 , pp. 1297-1306
    • Cosgrove, B.D.1
  • 82
    • 84880227965 scopus 로고    scopus 로고
    • Mesenchymal stem cell and chondrocyte fates in a multishear microdevice are regulated by Yes-associated protein
    • Zhong, W. et al. Mesenchymal stem cell and chondrocyte fates in a multishear microdevice are regulated by Yes-associated protein. Stem Cells Dev. 22, 2083-2093 (2013).
    • (2013) Stem Cells Dev. , vol.22 , pp. 2083-2093
    • Zhong, W.1
  • 83
    • 84876308427 scopus 로고    scopus 로고
    • Regulation of fibrochondrogenesis of mesenchymal stem cells in an integrated microfluidic platform embedded with biomimetic nanofibrous scaffolds
    • Zhong, W., Zhang, W., Wang, S. & Qin, J. Regulation of fibrochondrogenesis of mesenchymal stem cells in an integrated microfluidic platform embedded with biomimetic nanofibrous scaffolds. PLoS ONE 8, e61283 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e61283
    • Zhong, W.1    Zhang, W.2    Wang, S.3    Qin, J.4
  • 84
    • 84899091637 scopus 로고    scopus 로고
    • Shear stress induced by an interstitial level of slow flow increases the osteogenic differentiation of mesenchymal stem cells through TAZ activation
    • Kim, K. M. et al. Shear stress induced by an interstitial level of slow flow increases the osteogenic differentiation of mesenchymal stem cells through TAZ activation. PLoS ONE 9, e92427 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e92427
    • Kim, K.M.1
  • 85
    • 84979302731 scopus 로고    scopus 로고
    • Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede TAZ nuclear translocation
    • Chen, Z., Luo, Q., Lin, C., Kuang, D. & Song, G. Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede TAZ nuclear translocation. Sci. Rep. 6, 30322 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 30322
    • Chen, Z.1    Luo, Q.2    Lin, C.3    Kuang, D.4    Song, G.5
  • 86
    • 84871907591 scopus 로고    scopus 로고
    • The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells
    • Judson, R. N. et al. The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells. J. Cell Sci. 125, 6009-6019 (2012).
    • (2012) J. Cell Sci. , vol.125 , pp. 6009-6019
    • Judson, R.N.1
  • 87
    • 84988472811 scopus 로고    scopus 로고
    • Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis
    • Esteves de Lima, J., Bonnin, M. A., Birchmeier, C. & Duprez, D. Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis. eLife 5, e15593 (2016).
    • (2016) ELife , vol.5 , pp. e15593
    • Esteves De Lima, J.1    Bonnin, M.A.2    Birchmeier, C.3    Duprez, D.4
  • 88
    • 84856514914 scopus 로고    scopus 로고
    • Coordinating developmental signaling: Novel roles for the Hippo pathway
    • Varelas, X. & Wrana, J. L. Coordinating developmental signaling: novel roles for the Hippo pathway. Trends Cell Biol. 22, 88-96 (2012).
    • (2012) Trends Cell Biol. , vol.22 , pp. 88-96
    • Varelas, X.1    Wrana, J.L.2
  • 89
    • 84862146104 scopus 로고    scopus 로고
    • Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP
    • Strassburger, K., Tiebe, M., Pinna, F., Breuhahn, K. & Teleman, A. A. Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP. Dev. Biol. 367, 187-196 (2012).
    • (2012) Dev. Biol. , vol.367 , pp. 187-196
    • Strassburger, K.1    Tiebe, M.2    Pinna, F.3    Breuhahn, K.4    Teleman, A.A.5
  • 90
    • 84870610975 scopus 로고    scopus 로고
    • YAP mediates crosstalk between the Hippo and PI(3)K-TOR pathways by suppressing PTEN via miR-29
    • Tumaneng, K. et al. YAP mediates crosstalk between the Hippo and PI(3)K-TOR pathways by suppressing PTEN via miR-29. Nat. Cell Biol. 14, 1322-1329 (2012).
    • (2012) Nat. Cell Biol. , vol.14 , pp. 1322-1329
    • Tumaneng, K.1
  • 91
    • 35948961118 scopus 로고    scopus 로고
    • Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    • Zhao, B. et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 21, 2747-2761 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 2747-2761
    • Zhao, B.1
  • 92
    • 79953144263 scopus 로고    scopus 로고
    • Matrix stiffening sensitizes epithelial cells to EGF and enables the loss of contact inhibition of proliferation
    • Kim, J. H. & Asthagiri, A. R. Matrix stiffening sensitizes epithelial cells to EGF and enables the loss of contact inhibition of proliferation. J. Cell Sci. 124, 1280-1287 (2011).
    • (2011) J. Cell Sci. , vol.124 , pp. 1280-1287
    • Kim, J.H.1    Asthagiri, A.R.2
  • 93
    • 84997638357 scopus 로고    scopus 로고
    • MAPK-mediated YAP activation controls mechanical-tension-induced pulmonary alveolar regeneration
    • Liu, Z. et al. MAPK-mediated YAP activation controls mechanical-tension-induced pulmonary alveolar regeneration. Cell Rep. 16, 1810-1819 (2016).
    • (2016) Cell Rep. , vol.16 , pp. 1810-1819
    • Liu, Z.1
  • 94
    • 84968861346 scopus 로고    scopus 로고
    • Integrin signalling regulates YA P and TAZ to control skin homeostasis
    • Elbediwy, A. et al. Integrin signalling regulates YA P and TAZ to control skin homeostasis. Development 143, 1674-1687 (2016).
    • (2016) Development , vol.143 , pp. 1674-1687
    • Elbediwy, A.1
  • 95
    • 0036333993 scopus 로고    scopus 로고
    • A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair
    • Grose, R. et al. A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development 129, 2303-2315 (2002).
    • (2002) Development , vol.129 , pp. 2303-2315
    • Grose, R.1
  • 96
    • 79958735965 scopus 로고    scopus 로고
    • Actomyosin-mediated cellular tension drives increased tissue stiffness and beta-catenin activation to induce epidermal hyperplasia and tumor growth
    • Samuel, M. S. et al. Actomyosin-mediated cellular tension drives increased tissue stiffness and beta-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell 19, 776-791 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 776-791
    • Samuel, M.S.1
  • 97
    • 35748974863 scopus 로고    scopus 로고
    • Myocardial matrix remodeling and the matrix metalloproteinases: Influence on cardiac form and function
    • Spinale, F. G. Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol. Rev. 87, 1285-1342 (2007).
    • (2007) Physiol. Rev. , vol.87 , pp. 1285-1342
    • Spinale, F.G.1
  • 98
    • 84896911335 scopus 로고    scopus 로고
    • Hippo pathway effectors control cardiac progenitor cell fate by acting as dynamic sensors of substrate mechanics and nanostructure
    • Mosqueira, D. et al. Hippo pathway effectors control cardiac progenitor cell fate by acting as dynamic sensors of substrate mechanics and nanostructure. ACS Nano 8, 2033-2047 (2014).
    • (2014) ACS Nano , vol.8 , pp. 2033-2047
    • Mosqueira, D.1
  • 99
    • 84929089950 scopus 로고    scopus 로고
    • Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice
    • Morikawa, Y. et al. Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice. Sci. Signal. 8, ra41 (2015).
    • (2015) Sci. Signal. , vol.8 , pp. ra41
    • Morikawa, Y.1
  • 100
    • 84882740716 scopus 로고    scopus 로고
    • Hippo pathway effector Yap promotes cardiac regeneration
    • Xin, M. et al. Hippo pathway effector Yap promotes cardiac regeneration. Proc. Natl Acad. Sci. USA 110, 13839-13844 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 13839-13844
    • Xin, M.1
  • 101
    • 84897044348 scopus 로고    scopus 로고
    • Deletion of yes-associated protein (YAP) specifically in cardiac and vascular smooth muscle cells reveals a crucial role for YAP in mouse cardiovascular development
    • Wang, Y. et al. Deletion of yes-associated protein (YAP) specifically in cardiac and vascular smooth muscle cells reveals a crucial role for YAP in mouse cardiovascular development. Circ. Res. 114, 957-965 (2014).
    • (2014) Circ. Res. , vol.114 , pp. 957-965
    • Wang, Y.1
  • 102
    • 84984920689 scopus 로고    scopus 로고
    • Thromboxane A2 activates YAP/TAZ protein to induce vascular smooth muscle cell proliferation and migration
    • Feng, X. et al. Thromboxane A2 activates YAP/TAZ protein to induce vascular smooth muscle cell proliferation and migration. J. Biol. Chem. 291, 18947-18958 (2016).
    • (2016) J. Biol. Chem. , vol.291 , pp. 18947-18958
    • Feng, X.1
  • 103
    • 84949200386 scopus 로고    scopus 로고
    • The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP
    • Kimura, T. E. et al. The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP. J. Mol. Cell Cardiol. 90, 1-10 (2016).
    • (2016) J. Mol. Cell Cardiol. , vol.90 , pp. 1-10
    • Kimura, T.E.1
  • 104
    • 84861998879 scopus 로고    scopus 로고
    • Mechanics and function of the pulmonary vasculature: Implications for pulmonary vascular disease and right ventricular function
    • Lammers, S. et al. Mechanics and function of the pulmonary vasculature: implications for pulmonary vascular disease and right ventricular function. Compr. Physiol. 2, 295-319 (2012).
    • (2012) Compr. Physiol. , vol.2 , pp. 295-319
    • Lammers, S.1
  • 105
    • 84947433351 scopus 로고    scopus 로고
    • Matrix remodeling promotes pulmonary hypertension through feedback mechanoactivation of the YAP/TAZ-miR-130/301 circuit
    • Bertero, T. et al. Matrix remodeling promotes pulmonary hypertension through feedback mechanoactivation of the YAP/TAZ-miR-130/301 circuit. Cell Rep. 13, 1016-1032 (2015).
    • (2015) Cell Rep. , vol.13 , pp. 1016-1032
    • Bertero, T.1
  • 106
    • 84987849527 scopus 로고    scopus 로고
    • Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension
    • Bertero, T. et al. Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension. J. Clin. Invest. 126, 3313-3335 (2016).
    • (2016) J. Clin. Invest. , vol.126 , pp. 3313-3335
    • Bertero, T.1
  • 107
    • 84925060829 scopus 로고    scopus 로고
    • Fibrosis-a common pathway to organ injury and failure
    • Rockey, D. C., Bell, P. D. & Hill, J. A. Fibrosis-a common pathway to organ injury and failure. N. Engl. J. Med. 372, 1138-1149 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 1138-1149
    • Rockey, D.C.1    Bell, P.D.2    Hill, J.A.3
  • 108
    • 84983102616 scopus 로고    scopus 로고
    • The Hippo pathway effector YAP controls mouse hepatic stellate cell activation
    • Mannaerts, I. et al. The Hippo pathway effector YAP controls mouse hepatic stellate cell activation. J. Hepatol. 63, 679-688 (2015).
    • (2015) J. Hepatol. , vol.63 , pp. 679-688
    • Mannaerts, I.1
  • 109
    • 84959420962 scopus 로고    scopus 로고
    • Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation
    • Caliari, S. R. et al. Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation. Sci. Rep. 6, 21387 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 21387
    • Caliari, S.R.1
  • 110
    • 84922967715 scopus 로고    scopus 로고
    • Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis
    • Liu, F. et al. Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 308, L344-L357 (2015).
    • (2015) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.308 , pp. L344-L357
    • Liu, F.1
  • 111
    • 85014589873 scopus 로고    scopus 로고
    • TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression
    • Jorgenson, A. J. et al. TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression. Am. J. Physiol. Cell Physiol. 312, C277-C285 (2017).
    • (2017) Am. J. Physiol. Cell Physiol. , vol.312 , pp. C277-C285
    • Jorgenson, A.J.1
  • 112
    • 85012938717 scopus 로고    scopus 로고
    • TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts
    • Noguchi, S. et al. TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts. Sci. Rep. 7, 42595 (2017).
    • (2017) Sci. Rep. , vol.7 , pp. 42595
    • Noguchi, S.1
  • 113
    • 78049451932 scopus 로고    scopus 로고
    • The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program
    • Cai, J. et al. The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev. 24, 2383-2388 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 2383-2388
    • Cai, J.1
  • 114
    • 66849101632 scopus 로고    scopus 로고
    • Adhesion signaling-crosstalk between integrins Src and Rho
    • Huveneers, S. & Danen, E. H. Adhesion signaling-crosstalk between integrins, Src and Rho. J. Cell Sci. 122, 1059-1069 (2009).
    • (2009) J. Cell Sci. , vol.122 , pp. 1059-1069
    • Huveneers, S.1    Danen, E.H.2
  • 115
    • 84956831227 scopus 로고    scopus 로고
    • Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction
    • Nowell, C. S. et al. Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction. Nat. Cell Biol. 18, 168-180 (2016).
    • (2016) Nat. Cell Biol. , vol.18 , pp. 168-180
    • Nowell, C.S.1
  • 116
    • 84903764153 scopus 로고    scopus 로고
    • Cellular microenvironments reveal defective mechanosensing responses and elevated YAP signaling in LMNA-mutated muscle precursors
    • Bertrand, A. T. et al. Cellular microenvironments reveal defective mechanosensing responses and elevated YAP signaling in LMNA-mutated muscle precursors. J. Cell Sci. 127, 2873-2884 (2014).
    • (2014) J. Cell Sci. , vol.127 , pp. 2873-2884
    • Bertrand, A.T.1
  • 118
    • 81055140859 scopus 로고    scopus 로고
    • The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells
    • Cordenonsi, M. et al. The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell 147, 759-772 (2011).
    • (2011) Cell , vol.147 , pp. 759-772
    • Cordenonsi, M.1
  • 119
    • 33646365644 scopus 로고    scopus 로고
    • Lysyl oxidase is essential for hypoxia-induced metastasis
    • Erler, J. T. et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440, 1222-1226 (2006).
    • (2006) Nature , vol.440 , pp. 1222-1226
    • Erler, J.T.1
  • 120
    • 70450222098 scopus 로고    scopus 로고
    • Matrix crosslinking forces tumor progression by enhancing integrin signaling
    • Levental, K. R. et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139, 891-906 (2009).
    • (2009) Cell , vol.139 , pp. 891-906
    • Levental, K.R.1
  • 121
    • 84946781278 scopus 로고    scopus 로고
    • Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors
    • Lin, C. H. et al. Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors. Mol. Biol. Cell 26, 3946-3953 (2015).
    • (2015) Mol. Biol. Cell , vol.26 , pp. 3946-3953
    • Lin, C.H.1
  • 122
    • 84928008693 scopus 로고    scopus 로고
    • Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin beta1/FAK signaling
    • Hirata, E. et al. Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin beta1/FAK signaling. Cancer Cell 27, 574-588 (2015).
    • (2015) Cancer Cell , vol.27 , pp. 574-588
    • Hirata, E.1
  • 123
    • 84959345677 scopus 로고    scopus 로고
    • Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation
    • Kim, M. H. et al. Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation. EMBO J. 35, 462-478 (2016).
    • (2016) EMBO J. , vol.35 , pp. 462-478
    • Kim, M.H.1
  • 124
    • 84929514666 scopus 로고    scopus 로고
    • The Hippo transducer TAZ promotes epithelial to mesenchymal transition and cancer stem cell maintenance in oral cancer
    • Li, Z. et al. The Hippo transducer TAZ promotes epithelial to mesenchymal transition and cancer stem cell maintenance in oral cancer. Mol. Oncol. 9, 1091-1105 (2015).
    • (2015) Mol. Oncol. , vol.9 , pp. 1091-1105
    • Li, Z.1
  • 127
    • 84931275595 scopus 로고    scopus 로고
    • Cytoskeletal to nuclear strain transfer regulates YAP signaling in mesenchymal stem cells
    • Driscoll, T. P., Cosgrove, B. D., Heo, S. J., Shurden, Z. E. & Mauck, R. L. Cytoskeletal to nuclear strain transfer regulates YAP signaling in mesenchymal stem cells. Biophys. J. 108, 2783-2793 (2015).
    • (2015) Biophys. J. , vol.108 , pp. 2783-2793
    • Driscoll, T.P.1    Cosgrove, B.D.2    Heo, S.J.3    Shurden, Z.E.4    Mauck, R.L.5
  • 128
    • 84883059455 scopus 로고    scopus 로고
    • Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation
    • Swift, J. et al. Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Science 341, 1240104 (2013).
    • (2013) Science , vol.341 , pp. 1240104
    • Swift, J.1
  • 129
    • 84865260845 scopus 로고    scopus 로고
    • Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling
    • Yu, F. X. et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell 150, 780-791 (2012).
    • (2012) Cell , vol.150 , pp. 780-791
    • Yu, F.X.1
  • 130
    • 84884217043 scopus 로고    scopus 로고
    • A global pattern of mechanical stress polarizes cell divisions and cell shape in the growing Drosophila wing disc
    • Legoff, L., Rouault, H. & Lecuit, T. A global pattern of mechanical stress polarizes cell divisions and cell shape in the growing Drosophila wing disc. Development 140, 4051-4059 (2013).
    • (2013) Development , vol.140 , pp. 4051-4059
    • Legoff, L.1    Rouault, H.2    Lecuit, T.3
  • 132
    • 84857129984 scopus 로고    scopus 로고
    • Premetazoan origin of the hippo signaling pathway
    • Sebe-Pedros, A., Zheng, Y., Ruiz-Trillo, I. & Pan, D. Premetazoan origin of the hippo signaling pathway. Cell Rep. 1, 13-20 (2012).
    • (2012) Cell Rep. , vol.1 , pp. 13-20
    • Sebe-Pedros, A.1    Zheng, Y.2    Ruiz-Trillo, I.3    Pan, D.4
  • 133
    • 85017108800 scopus 로고    scopus 로고
    • Stem cell-derived organoids and their application for medical research and patient treatment
    • Bartfeld, S. & Clevers, H. Stem cell-derived organoids and their application for medical research and patient treatment. J. Mol. Med. 95, 729-738 (2017).
    • (2017) J. Mol. Med. , vol.95 , pp. 729-738
    • Bartfeld, S.1    Clevers, H.2
  • 135
    • 84993927163 scopus 로고    scopus 로고
    • Human airway organoid engineering as a step toward lung regeneration and disease modeling
    • Tan, Q., Choi, K. M., Sicard, D. & Tschumperlin, D. J. Human airway organoid engineering as a step toward lung regeneration and disease modeling. Biomaterials 113, 118-132 (2017).
    • (2017) Biomaterials , vol.113 , pp. 118-132
    • Tan, Q.1    Choi, K.M.2    Sicard, D.3    Tschumperlin, D.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.