Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation

Science

Volumn 341, Issue 6149, 2013, Pages

  Swift, Joe ^a   Ivanovska, Irena L ^a   Buxboim, Amnon ^a   Harada, Takamasa ^a   Dingal, P C Dave P ^a   Pinter, Joel ^a   Pajerowski, J David ^a   Spinler, Kyle R ^a   Shin, Jae Won ^a   Tewari, Manorama ^a   Rehfeldt, Florian ^a   Speicher, David W ^b   Discher, Dennis E ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LAMIN A; LAMIN B; RETINOIC ACID; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; COLLAGEN; PROTEOME; RETINOL;

BIOMECHANICS; GENE EXPRESSION; PROTEIN; PROTEOMICS; SKELETON; VITAMIN;

ARTICLE; DOWNSTREAM PROCESSING; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; MASS SPECTROMETRY; MESENCHYMAL STEM CELL; MOLECULAR MECHANICS; MUSCLE RIGIDITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEOMICS; QUANTITATIVE STUDY; STEM CELL; STOICHIOMETRY; TISSUE CULTURE CELL; TISSUE DIFFERENTIATION; TUMOR XENOGRAFT; ADIPOGENESIS; ANIMAL; BIOLOGICAL MODEL; BONE DEVELOPMENT; CELL DIFFERENTIATION; CHEMISTRY; CYTOLOGY; ELASTICITY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MECHANICAL STRESS; MESENCHYMAL STROMA CELL; METABOLISM; MOUSE; NUCLEAR LAMINA;

ADIPOGENESIS; ANIMALS; CELL DIFFERENTIATION; COLLAGEN; ELASTICITY; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; LAMIN TYPE A; MESENCHYMAL STROMAL CELLS; MICE; MODELS, BIOLOGICAL; NUCLEAR LAMINA; OSTEOGENESIS; PROTEIN CONFORMATION; PROTEOME; STRESS, MECHANICAL; TRANSCRIPTION, GENETIC; TRETINOIN; VITAMIN A;

EID: 84883059455     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1240104     Document Type: Article

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