YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers

Molecular Cell

Volumn 60, Issue 2, 2015, Pages 328-337

  Galli, Giorgio G ^a,b,c,g   Carrara, Matteo ^d   Yuan, Wei Chien ^a,b,c   Valdes Quezada, Christian ^e   Gurung, Basanta ^a,c   Pepe Mooney, Brian ^a,b   Zhang, Tinghu ^f   Geeven, Geert ^e   Gray, Nathanael S ^f   de Laat, Wouter ^e   Calogero, Raffaele A ^d   Camargo, Fernando D ^a,b,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b Harvard University   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

^d UNIVERSITY OF TURIN   (Italy)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f DANA FARBER CANCER INSTITUTE   (United States)

^g NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 9; MEDIATOR COMPLEX; RNA POLYMERASE II; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TAZ; TRANSCRIPTION FACTOR YAP; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CDK9 PROTEIN, HUMAN; CHROMATIN; DNA DIRECTED DNA POLYMERASE ALPHA; FLAVONOID; FLAVOPIRIDOL; PHOSPHOPROTEIN; PIPERIDINE DERIVATIVE; PROTEIN BINDING; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; WWTR1 PROTEIN, HUMAN; WWTR1 PROTEIN, MOUSE; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CHROMATIN; CONTROLLED STUDY; ENHANCER REGION; GENOME ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROMOTER REGION; PROTEIN BINDING; TRANSCRIPTION ELONGATION; TRANSCRIPTION REGULATION; ANIMAL; BILE DUCT NEOPLASMS; CHEMISTRY; CHOLANGIOCARCINOMA; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTINEOPLASTIC AGENTS; BILE DUCT NEOPLASMS; CARCINOGENESIS; CELL LINE, TUMOR; CHOLANGIOCARCINOMA; CHROMATIN; CYCLIN-DEPENDENT KINASE 9; DNA POLYMERASE II; ENHANCER ELEMENTS, GENETIC; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEDIATOR COMPLEX; MICE; MICE, TRANSGENIC; PHOSPHOPROTEINS; PIPERIDINES; PROTEIN BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84944897345     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.09.001     Document Type: Article

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