Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 41, 2016, Pages 11525-11530

  Wang, Kuei Chun ^a   Yeh, Yi Ting ^a   Nguyen, Phu ^a   Limqueco, Elaine ^a   Lopez, Jocelyn ^a   Thorossian, Satenick ^a   Guan, Kun Liang ^b   Li, Yi Shuan J ^a   Chien, Shu ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b San Diego   (United States)

Author keywords

Atherogenesis; Disturbed flow; Endothelial cells; Mechanotransduction

Indexed keywords

ANKYRIN; ANKYRIN REPEAT DOMAIN 1; CONNECTIVE TISSUE GROWTH FACTOR; CYSTEINE RICH PROTEIN 61; MORPHOLINO OLIGONUCLEOTIDE; SIMVASTATIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TAZ; UNCLASSIFIED DRUG; YES ASSOCIATED PROTEIN; ANKRD1 PROTEIN, HUMAN; APOLIPOPROTEIN E; CYR61 PROTEIN, MOUSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MUSCLE PROTEIN; NUCLEAR PROTEIN; PHOSPHOPROTEIN; REPRESSOR PROTEIN; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; WWTR1 PROTEIN, HUMAN; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ARCH; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROGENESIS; CAROTID ARTERY; CAROTID ATHEROSCLEROSIS; CELL CULTURE; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LAMINAR FLOW; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; OSCILLATION; PHENOTYPE; PRIORITY JOURNAL; SHEAR STRESS; TRANSCRIPTION REGULATION; TRANSLATION INITIATION; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; ATHEROSCLEROSIS; CELL CYCLE; COMMON CAROTID ARTERY; DEFICIENCY; DRUG EFFECTS; FLOW KINETICS; GENE KNOCKDOWN; METABOLISM; PATHOLOGY; VASCULAR ENDOTHELIUM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CAROTID ARTERY, COMMON; CELL CYCLE; CELL NUCLEUS; CELL PROLIFERATION; CONNECTIVE TISSUE GROWTH FACTOR; CYSTEINE-RICH PROTEIN 61; ENDOTHELIUM, VASCULAR; GENE KNOCKDOWN TECHNIQUES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFLAMMATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MUSCLE PROTEINS; NUCLEAR PROTEINS; PHENOTYPE; PHOSPHOPROTEINS; REPRESSOR PROTEINS; RHEOLOGY;

EID: 84991502908     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1613121113     Document Type: Article

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