-
1
-
-
84878821943
-
Coronary stents: historical development, current status and future directions
-
Iqbal, J., Gunn, J., Serruys, P.W., Coronary stents: historical development, current status and future directions. Br Med Bull 106 (2013), 193–211.
-
(2013)
Br Med Bull
, vol.106
, pp. 193-211
-
-
Iqbal, J.1
Gunn, J.2
Serruys, P.W.3
-
2
-
-
0025881724
-
History of the design of captopril and related inhibitors of angiotensin converting enzyme
-
Cushman, D.W., Ondetti, M.A., History of the design of captopril and related inhibitors of angiotensin converting enzyme. Hypertension 17 (1991), 589–592.
-
(1991)
Hypertension
, vol.17
, pp. 589-592
-
-
Cushman, D.W.1
Ondetti, M.A.2
-
3
-
-
34247854930
-
Decline in rates of death and heart failure in acute coronary syndromes, 1999–2006
-
Fox, K.A., Steg, P.G., Eagle, K.A., et al. Decline in rates of death and heart failure in acute coronary syndromes, 1999–2006. JAMA 297 (2007), 1892–1900.
-
(2007)
JAMA
, vol.297
, pp. 1892-1900
-
-
Fox, K.A.1
Steg, P.G.2
Eagle, K.A.3
-
4
-
-
40949131340
-
Medication nonadherence is associated with a broad range of adverse outcomes in patients with coronary artery disease
-
Ho, P.M., Magid, D.J., Shetterly, S.M., et al. Medication nonadherence is associated with a broad range of adverse outcomes in patients with coronary artery disease. Am Heart J 155 (2008), 772–779.
-
(2008)
Am Heart J
, vol.155
, pp. 772-779
-
-
Ho, P.M.1
Magid, D.J.2
Shetterly, S.M.3
-
5
-
-
85013228246
-
Recent trends in cardiovascular mortality in the United States and public health goals
-
Sidney, S., Quesenberry, C.P. Jr., Jaffe, M.G., et al. Recent trends in cardiovascular mortality in the United States and public health goals. JAMA Cardiol 1 (2016), 594–599.
-
(2016)
JAMA Cardiol
, vol.1
, pp. 594-599
-
-
Sidney, S.1
Quesenberry, C.P.2
Jaffe, M.G.3
-
6
-
-
84937968994
-
Genome-wide association studies of late-onset cardiovascular disease
-
Smith, J.G., Newton-Cheh, C., Genome-wide association studies of late-onset cardiovascular disease. J Mol Cell Cardiol 83 (2015), 131–141.
-
(2015)
J Mol Cell Cardiol
, vol.83
, pp. 131-141
-
-
Smith, J.G.1
Newton-Cheh, C.2
-
7
-
-
84977636037
-
The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease
-
Kessler, T., Vilne, B., Schunkert, H., The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease. EMBO Mol Med 8 (2016), 688–701.
-
(2016)
EMBO Mol Med
, vol.8
, pp. 688-701
-
-
Kessler, T.1
Vilne, B.2
Schunkert, H.3
-
8
-
-
84984870481
-
Genetics and genomics of coronary artery disease
-
Pjanic, M., Miller, C.L., Wirka, R., Kim, J.B., DiRenzo, D.M., Quertermous, T., Genetics and genomics of coronary artery disease. Curr Cardiol Rep, 18, 2016, 102.
-
(2016)
Curr Cardiol Rep
, vol.18
, pp. 102
-
-
Pjanic, M.1
Miller, C.L.2
Wirka, R.3
Kim, J.B.4
DiRenzo, D.M.5
Quertermous, T.6
-
9
-
-
84960891322
-
Genetic loci associated with ideal cardiovascular health: a meta-analysis of genome-wide association studies
-
Allen, N.B., Lloyd-Jones, D., Hwang, S.J., et al. Genetic loci associated with ideal cardiovascular health: a meta-analysis of genome-wide association studies. Am Heart J 175 (2016), 112–120.
-
(2016)
Am Heart J
, vol.175
, pp. 112-120
-
-
Allen, N.B.1
Lloyd-Jones, D.2
Hwang, S.J.3
-
10
-
-
84862909349
-
Five years of GWAS discovery
-
Visscher, P.M., Brown, M.A., McCarthy, M.I., Yang, J., Five years of GWAS discovery. Am J Hum Genet 90 (2012), 7–24.
-
(2012)
Am J Hum Genet
, vol.90
, pp. 7-24
-
-
Visscher, P.M.1
Brown, M.A.2
McCarthy, M.I.3
Yang, J.4
-
11
-
-
84923342405
-
Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders
-
Bjorkegren, J.L., Kovacic, J.C., Dudley, J.T., Schadt, E.E., Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders. J Am Coll Cardiol 65 (2015), 830–845.
-
(2015)
J Am Coll Cardiol
, vol.65
, pp. 830-845
-
-
Bjorkegren, J.L.1
Kovacic, J.C.2
Dudley, J.T.3
Schadt, E.E.4
-
12
-
-
84891858260
-
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects
-
Shameer, K., Denny, J.C., Ding, K., et al. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. Hum Genet 133 (2014), 95–109.
-
(2014)
Hum Genet
, vol.133
, pp. 95-109
-
-
Shameer, K.1
Denny, J.C.2
Ding, K.3
-
13
-
-
0035204617
-
Realism in drug discovery—could Cassandra be right?
-
Horrobin, D.F., Realism in drug discovery—could Cassandra be right?. Nat Biotechnol 19 (2001), 1099–1100.
-
(2001)
Nat Biotechnol
, vol.19
, pp. 1099-1100
-
-
Horrobin, D.F.1
-
14
-
-
79957889347
-
The productivity crisis in pharmaceutical R&D
-
Pammolli, F., Magazzini, L., Riccaboni, M., The productivity crisis in pharmaceutical R&D. Nat Rev Drug Discov 10 (2011), 428–438.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 428-438
-
-
Pammolli, F.1
Magazzini, L.2
Riccaboni, M.3
-
15
-
-
84928036813
-
Cardiovascular drug development: is it dead or just hibernating?
-
Fordyce, C.B., Roe, M.T., Ahmad, T., et al. Cardiovascular drug development: is it dead or just hibernating?. J Am Coll Cardiol 65 (2015), 1567–1582.
-
(2015)
J Am Coll Cardiol
, vol.65
, pp. 1567-1582
-
-
Fordyce, C.B.1
Roe, M.T.2
Ahmad, T.3
-
16
-
-
48149083115
-
The failure of torcetrapib: what have we learned?
-
Joy, T.R., Hegele, R.A., The failure of torcetrapib: what have we learned?. Br J Pharmacol 154 (2008), 1379–1381.
-
(2008)
Br J Pharmacol
, vol.154
, pp. 1379-1381
-
-
Joy, T.R.1
Hegele, R.A.2
-
17
-
-
84987854661
-
Cholesteryl ester transfer protein inhibitors: trials and tribulations
-
[E-pub ahead of print]
-
McLain, J.H., Alsterda, A.J., Arora, R.R., Cholesteryl ester transfer protein inhibitors: trials and tribulations. J Cardiovasc Pharmacol Ther, 2016 Aug 10 [E-pub ahead of print].
-
(2016)
J Cardiovasc Pharmacol Ther
-
-
McLain, J.H.1
Alsterda, A.J.2
Arora, R.R.3
-
18
-
-
84959569935
-
Cholesteryl ester transfer protein inhibition is not yet dead—pro
-
Barter, P.J., Rye, K.A., Cholesteryl ester transfer protein inhibition is not yet dead—pro. Arterioscler Thromb Vasc Biol 36 (2016), 439–441.
-
(2016)
Arterioscler Thromb Vasc Biol
, vol.36
, pp. 439-441
-
-
Barter, P.J.1
Rye, K.A.2
-
19
-
-
84887963766
-
Network medicine in disease analysis and therapeutics
-
Chen, B., Butte, A.J., Network medicine in disease analysis and therapeutics. Clin Pharmacol Ther 94 (2013), 627–629.
-
(2013)
Clin Pharmacol Ther
, vol.94
, pp. 627-629
-
-
Chen, B.1
Butte, A.J.2
-
20
-
-
84963553689
-
In silico methods for drug repurposing and pharmacology
-
Hodos, R.A., Kidd, B.A., Shameer, K., Readhead, B.P., Dudley, J.T., In silico methods for drug repurposing and pharmacology. Wiley Interdiscip Rev Syst Biol Med 8 (2016), 186–210.
-
(2016)
Wiley Interdiscip Rev Syst Biol Med
, vol.8
, pp. 186-210
-
-
Hodos, R.A.1
Kidd, B.A.2
Shameer, K.3
Readhead, B.P.4
Dudley, J.T.5
-
21
-
-
84976448008
-
Precision medicine in cardiology
-
Antman, E.M., Loscalzo, J., Precision medicine in cardiology. Nat Rev Cardiol 13 (2016), 591–602.
-
(2016)
Nat Rev Cardiol
, vol.13
, pp. 591-602
-
-
Antman, E.M.1
Loscalzo, J.2
-
22
-
-
84961377536
-
Opportunities for the cardiovascular community in the precision medicine initiative
-
Shah, S.H., Arnett, D., Houser, S.R., et al. Opportunities for the cardiovascular community in the precision medicine initiative. Circulation 133 (2016), 226–231.
-
(2016)
Circulation
, vol.133
, pp. 226-231
-
-
Shah, S.H.1
Arnett, D.2
Houser, S.R.3
-
23
-
-
84931427223
-
Planning for US Precision Medicine Initiative underway
-
Jaffe, S., Planning for US Precision Medicine Initiative underway. Lancet 385 (2015), 2448–2449.
-
(2015)
Lancet
, vol.385
, pp. 2448-2449
-
-
Jaffe, S.1
-
24
-
-
84930439209
-
The precision medicine initiative: a new national effort
-
Ashley, E.A., The precision medicine initiative: a new national effort. JAMA 313 (2015), 2119–2120.
-
(2015)
JAMA
, vol.313
, pp. 2119-2120
-
-
Ashley, E.A.1
-
25
-
-
84923762812
-
A new initiative on precision medicine
-
Collins, F.S., Varmus, H., A new initiative on precision medicine. N Engl J Med 372 (2015), 793–795.
-
(2015)
N Engl J Med
, vol.372
, pp. 793-795
-
-
Collins, F.S.1
Varmus, H.2
-
26
-
-
84993973265
-
Clues toward precision medicine in oral squamous cell carcinoma: utility of next-generation sequencing for the prognostic stratification of high- risk patients harboring neck lymph node extracapsular extension
-
Wang, H.M., Liao, C.T., Yen, T.C., et al. Clues toward precision medicine in oral squamous cell carcinoma: utility of next-generation sequencing for the prognostic stratification of high- risk patients harboring neck lymph node extracapsular extension. Oncotarget 7 (2016), 63082–63092.
-
(2016)
Oncotarget
, vol.7
, pp. 63082-63092
-
-
Wang, H.M.1
Liao, C.T.2
Yen, T.C.3
-
27
-
-
84994087188
-
Lung cancer: current therapies and new targeted treatments
-
Hirsch, F.R., Scagliotti, G.V., Mulshine, J.L., et al. Lung cancer: current therapies and new targeted treatments. Lancet 389 (2017), 299–311.
-
(2017)
Lancet
, vol.389
, pp. 299-311
-
-
Hirsch, F.R.1
Scagliotti, G.V.2
Mulshine, J.L.3
-
28
-
-
85010433794
-
Precision medicine in NSCLC and pathology: how does ALK fit in the pathway?
-
Kerr, K.M., Lopez-Rios, F., Precision medicine in NSCLC and pathology: how does ALK fit in the pathway?. Ann Oncol 27:Suppl 3 (2016), iii16–iii24.
-
(2016)
Ann Oncol
, vol.27
, pp. iii16-iii24
-
-
Kerr, K.M.1
Lopez-Rios, F.2
-
29
-
-
84984940595
-
Ockham's razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer
-
Stella, G.M., Gentile, A., Baderacchi, A., Meloni, F., Milan, M., Benvenuti, S., Ockham's razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer. J Transl Med, 14, 2016, 256.
-
(2016)
J Transl Med
, vol.14
, pp. 256
-
-
Stella, G.M.1
Gentile, A.2
Baderacchi, A.3
Meloni, F.4
Milan, M.5
Benvenuti, S.6
-
30
-
-
84962381476
-
Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach
-
Ruderfer, D.M., Charney, A.W., Readhead, B., et al. Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach. Lancet Psychiatry 3 (2016), 350–357.
-
(2016)
Lancet Psychiatry
, vol.3
, pp. 350-357
-
-
Ruderfer, D.M.1
Charney, A.W.2
Readhead, B.3
-
31
-
-
77951589703
-
Clinical assessment incorporating a personal genome
-
Ashley, E.A., Butte, A.J., Wheeler, M.T., et al. Clinical assessment incorporating a personal genome. Lancet 375 (2010), 1525–1535.
-
(2010)
Lancet
, vol.375
, pp. 1525-1535
-
-
Ashley, E.A.1
Butte, A.J.2
Wheeler, M.T.3
-
32
-
-
84959230547
-
Incorporating a genetic risk score into coronary heart disease risk estimates: effect on low-density lipoprotein cholesterol levels (the MI-GENES Clinical Trial)
-
Kullo, I.J., Jouni, H., Austin, E.E., et al. Incorporating a genetic risk score into coronary heart disease risk estimates: effect on low-density lipoprotein cholesterol levels (the MI-GENES Clinical Trial). Circulation 133 (2016), 1181–1188.
-
(2016)
Circulation
, vol.133
, pp. 1181-1188
-
-
Kullo, I.J.1
Jouni, H.2
Austin, E.E.3
-
33
-
-
84920525015
-
Whole exome sequencing implicates an INO80D mutation in a syndrome of aortic hypoplasia, premature atherosclerosis, and arterial stiffness
-
Shameer, K., Klee, E.W., Dalenberg, A.K., Kullo, I.J., Whole exome sequencing implicates an INO80D mutation in a syndrome of aortic hypoplasia, premature atherosclerosis, and arterial stiffness. Circ Cardiovasc Genet 7 (2014), 607–614.
-
(2014)
Circ Cardiovasc Genet
, vol.7
, pp. 607-614
-
-
Shameer, K.1
Klee, E.W.2
Dalenberg, A.K.3
Kullo, I.J.4
-
34
-
-
77952786822
-
Genomic medicine—an updated primer
-
Feero, W.G., Guttmacher, A.E., Collins, F.S., Genomic medicine—an updated primer. N Engl J Med 362 (2010), 2001–2011.
-
(2010)
N Engl J Med
, vol.362
, pp. 2001-2011
-
-
Feero, W.G.1
Guttmacher, A.E.2
Collins, F.S.3
-
36
-
-
84968813824
-
Deep patient: an unsupervised representation to predict the future of patients from the electronic health records
-
Miotto, R., Li, L., Kidd, B.A., Dudley, J.T., Deep patient: an unsupervised representation to predict the future of patients from the electronic health records. Sci Rep, 6, 2016 May 17, 26094, 10.1038/srep26094.
-
(2016)
Sci Rep
, vol.6
, pp. 26094
-
-
Miotto, R.1
Li, L.2
Kidd, B.A.3
Dudley, J.T.4
-
37
-
-
0034712858
-
Evolution of biological complexity
-
Adami, C., Ofria, C., Collier, T.C., Evolution of biological complexity. Proceedings of the National Academy of Sciences 97 (2000), 4463–4468.
-
(2000)
Proceedings of the National Academy of Sciences
, vol.97
, pp. 4463-4468
-
-
Adami, C.1
Ofria, C.2
Collier, T.C.3
-
38
-
-
85019316083
-
Moving beyond regression techniques in cardiovascular risk prediction: applying machine learning to address analytic challenges
-
[E-pub ahead of print]
-
Goldstein, B.A., Navar, A.M., Carter, R.E., Moving beyond regression techniques in cardiovascular risk prediction: applying machine learning to address analytic challenges. Eur Heart J, 2016 Jul 19 [E-pub ahead of print].
-
(2016)
Eur Heart J
-
-
Goldstein, B.A.1
Navar, A.M.2
Carter, R.E.3
-
39
-
-
84862200972
-
Escaping the EHR trap—the future of health IT
-
Mandl, K.D., Kohane, I.S., Escaping the EHR trap—the future of health IT. N Engl J Med 366 (2012), 2240–2242.
-
(2012)
N Engl J Med
, vol.366
, pp. 2240-2242
-
-
Mandl, K.D.1
Kohane, I.S.2
-
41
-
-
84975795358
-
Cognitive machine-learning algorithm for cardiac imaging: a pilot study for differentiating constrictive pericarditis from restrictive cardiomyopathy
-
Sengupta, P.P., Huang, Y.M., Bansal, M., et al. Cognitive machine-learning algorithm for cardiac imaging: a pilot study for differentiating constrictive pericarditis from restrictive cardiomyopathy. Circ Cardiovasc Imaging, 9, 2016, e004330.
-
(2016)
Circ Cardiovasc Imaging
, vol.9
, pp. e004330
-
-
Sengupta, P.P.1
Huang, Y.M.2
Bansal, M.3
-
42
-
-
84997693769
-
Machine-learning algorithms to automate morphological and functional assessments in 2D echocardiography
-
Narula, S., Shameer, K., Salem Omar, A.M., Dudley, J.T., Sengupta, P.P., Machine-learning algorithms to automate morphological and functional assessments in 2D echocardiography. J Am Coll Cardiol 68 (2016), 2287–2295.
-
(2016)
J Am Coll Cardiol
, vol.68
, pp. 2287-2295
-
-
Narula, S.1
Shameer, K.2
Salem Omar, A.M.3
Dudley, J.T.4
Sengupta, P.P.5
-
43
-
-
79960575553
-
3dswap-pred: prediction of 3D domain swapping from protein sequence using Random Forest approach
-
Shameer, K., Pugalenthi, G., Kandaswamy, K.K., Sowdhamini, R., 3dswap-pred: prediction of 3D domain swapping from protein sequence using Random Forest approach. Protein Pept Lett 18 (2011), 1010–1020.
-
(2011)
Protein Pept Lett
, vol.18
, pp. 1010-1020
-
-
Shameer, K.1
Pugalenthi, G.2
Kandaswamy, K.K.3
Sowdhamini, R.4
-
44
-
-
77955242486
-
Insights into protein sequence and structure-derived features mediating 3D domain swapping mechanism using support vector machine based approach
-
Shameer, K., Pugalenthi, G., Kandaswamy, K.K., Suganthan, P.N., Archunan, G., Sowdhamini, R., Insights into protein sequence and structure-derived features mediating 3D domain swapping mechanism using support vector machine based approach. Bioinform Biol Insights 4 (2010), 33–42.
-
(2010)
Bioinform Biol Insights
, vol.4
, pp. 33-42
-
-
Shameer, K.1
Pugalenthi, G.2
Kandaswamy, K.K.3
Suganthan, P.N.4
Archunan, G.5
Sowdhamini, R.6
-
45
-
-
84990892368
-
Drug response prediction by inferring pathway-response associations with kernelized Bayesian matrix factorization
-
Ammad-Ud-Din, M., Khan, S.A., Malani, D., et al. Drug response prediction by inferring pathway-response associations with kernelized Bayesian matrix factorization. Bioinformatics 32 (2016), i455–i463.
-
(2016)
Bioinformatics
, vol.32
, pp. i455-i463
-
-
Ammad-Ud-Din, M.1
Khan, S.A.2
Malani, D.3
-
46
-
-
84983631327
-
Classification of breast cancer patients using somatic mutation profiles and machine learning approaches
-
Vural, S., Wang, X., Guda, C., Classification of breast cancer patients using somatic mutation profiles and machine learning approaches. BMC Syst Biol, 10(Suppl 3), 2016, 62.
-
(2016)
BMC Syst Biol
, vol.10
, pp. 62
-
-
Vural, S.1
Wang, X.2
Guda, C.3
-
47
-
-
85034104472
-
Multi-parametric non-negative matrix factorization for longitudinal variations detection in white matter fiber-bundles
-
[E-pub ahead of print]
-
Stamile, C., Kocevar, G., Cotton, F., Maes, F., Sappey-Marinier, D., Huffel, S.V., Multi-parametric non-negative matrix factorization for longitudinal variations detection in white matter fiber-bundles. IEEE J Biomed Health Inform, 2016 Aug 3 [E-pub ahead of print].
-
(2016)
IEEE J Biomed Health Inform
-
-
Stamile, C.1
Kocevar, G.2
Cotton, F.3
Maes, F.4
Sappey-Marinier, D.5
Huffel, S.V.6
-
48
-
-
84995421882
-
Topological data analysis generates high-resolution, genome-wide maps of human recombination
-
Camara, P.G., Rosenbloom, D.I., Emmett, K.J., Levine, A.J., Rabadan, R., Topological data analysis generates high-resolution, genome-wide maps of human recombination. Cell Syst 3 (2016), 83–94.
-
(2016)
Cell Syst
, vol.3
, pp. 83-94
-
-
Camara, P.G.1
Rosenbloom, D.I.2
Emmett, K.J.3
Levine, A.J.4
Rabadan, R.5
-
49
-
-
84978194066
-
A multimodal data analysis approach for targeted drug discovery involving topological data analysis (TDA)
-
Alagappan, M., Jiang, D., Denko, N., Koong, A.C., A multimodal data analysis approach for targeted drug discovery involving topological data analysis (TDA). Adv Exp Med Biol 899 (2016), 253–268.
-
(2016)
Adv Exp Med Biol
, vol.899
, pp. 253-268
-
-
Alagappan, M.1
Jiang, D.2
Denko, N.3
Koong, A.C.4
-
50
-
-
84945197673
-
Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury
-
Nielson, J.L., Paquette, J., Liu, A.W., et al. Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury. Nat Commun, 6, 2015, 8581.
-
(2015)
Nat Commun
, vol.6
, pp. 8581
-
-
Nielson, J.L.1
Paquette, J.2
Liu, A.W.3
-
51
-
-
84961972497
-
Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data
-
Hinks, T., Zhou, X., Staples, K., et al. Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data. Lancet, 385(Suppl 1), 2015, S42.
-
(2015)
Lancet
, vol.385
, pp. S42
-
-
Hinks, T.1
Zhou, X.2
Staples, K.3
-
52
-
-
84971231452
-
Unsupervised feature construction and knowledge extraction from genome-wide assays of breast cancer with denoising autoencoders
-
Tan, J., Ung, M., Cheng, C., Greene, C.S., Unsupervised feature construction and knowledge extraction from genome-wide assays of breast cancer with denoising autoencoders. Pac Symp Biocomput 20 (2015), 132–143.
-
(2015)
Pac Symp Biocomput
, vol.20
, pp. 132-143
-
-
Tan, J.1
Ung, M.2
Cheng, C.3
Greene, C.S.4
-
53
-
-
84990888204
-
DeepChrome: deep-learning for predicting gene expression from histone modifications
-
Singh, R., Lanchantin, J., Robins, G., Qi, Y., DeepChrome: deep-learning for predicting gene expression from histone modifications. Bioinformatics 32 (2016), i639–i648.
-
(2016)
Bioinformatics
, vol.32
, pp. i639-i648
-
-
Singh, R.1
Lanchantin, J.2
Robins, G.3
Qi, Y.4
-
54
-
-
85000428361
-
Digital mammographic tumor classification using transfer learning from deep convolutional neural networks
-
Huynh, B.Q., Li, H., Giger, M.L., Digital mammographic tumor classification using transfer learning from deep convolutional neural networks. J Med Imaging (Bellingham), 3, 2016, 034501.
-
(2016)
J Med Imaging (Bellingham)
, vol.3
, pp. 034501
-
-
Huynh, B.Q.1
Li, H.2
Giger, M.L.3
-
55
-
-
85009238256
-
Deep learning for digital pathology image analysis: A comprehensive tutorial with selected use cases
-
Janowczyk, A., Madabhushi, A., Deep learning for digital pathology image analysis: A comprehensive tutorial with selected use cases. J Pathol Inform, 7, 2016, 29.
-
(2016)
J Pathol Inform
, vol.7
, pp. 29
-
-
Janowczyk, A.1
Madabhushi, A.2
-
56
-
-
84981288331
-
DL-ADR: a novel deep learning model for classifying genomic variants into adverse drug reactions
-
Liang, Z., Huang, J.X., Zeng, X., Zhang, G., DL-ADR: a novel deep learning model for classifying genomic variants into adverse drug reactions. BMC Med Genomics, 9(Suppl 2), 2016, 48.
-
(2016)
BMC Med Genomics
, vol.9
, pp. 48
-
-
Liang, Z.1
Huang, J.X.2
Zeng, X.3
Zhang, G.4
-
57
-
-
85016146323
-
Using recurrent neural network models for early detection of heart failure onset
-
Choi, E., Schuetz, A., Stewart, W.F., Sun, J., Using recurrent neural network models for early detection of heart failure onset. J Am Med Inform Assoc 24 (2017), 361–370.
-
(2017)
J Am Med Inform Assoc
, vol.24
, pp. 361-370
-
-
Choi, E.1
Schuetz, A.2
Stewart, W.F.3
Sun, J.4
-
58
-
-
84986243956
-
The Next Era: Deep learning in pharmaceutical research
-
Ekins, S., The Next Era: Deep learning in pharmaceutical research. Pharm Res 33 (2016), 2594–2603.
-
(2016)
Pharm Res
, vol.33
, pp. 2594-2603
-
-
Ekins, S.1
-
59
-
-
84954372459
-
Deep learning in drug discovery
-
Gawehn, E., Hiss, J.A., Schneider, G., Deep learning in drug discovery. Mol Inform 35 (2016), 3–14.
-
(2016)
Mol Inform
, vol.35
, pp. 3-14
-
-
Gawehn, E.1
Hiss, J.A.2
Schneider, G.3
-
60
-
-
84980348164
-
Ensembles of deep learning architectures for the early diagnosis of the Alzheimer's disease
-
Ortiz, A., Munilla, J., Gorriz, J.M., Ramirez, J., Ensembles of deep learning architectures for the early diagnosis of the Alzheimer's disease. Int J Neural Syst, 26, 2016, 1650025.
-
(2016)
Int J Neural Syst
, vol.26
, pp. 1650025
-
-
Ortiz, A.1
Munilla, J.2
Gorriz, J.M.3
Ramirez, J.4
-
61
-
-
84978204565
-
Combining deep learning and level set for the automated segmentation of the left ventricle of the heart from cardiac cine magnetic resonance
-
Ngo, T.A., Lu, Z., Carneiro, G., Combining deep learning and level set for the automated segmentation of the left ventricle of the heart from cardiac cine magnetic resonance. Med Image Anal 35 (2016), 159–171.
-
(2016)
Med Image Anal
, vol.35
, pp. 159-171
-
-
Ngo, T.A.1
Lu, Z.2
Carneiro, G.3
-
62
-
-
84979019529
-
Deep learning applications for predicting pharmacological properties of drugs and drug repurposing using transcriptomic data
-
Aliper, A., Plis, S., Artemov, A., Ulloa, A., Mamoshina, P., Zhavoronkov, A., Deep learning applications for predicting pharmacological properties of drugs and drug repurposing using transcriptomic data. Mol Pharm 13 (2016), 2524–2530.
-
(2016)
Mol Pharm
, vol.13
, pp. 2524-2530
-
-
Aliper, A.1
Plis, S.2
Artemov, A.3
Ulloa, A.4
Mamoshina, P.5
Zhavoronkov, A.6
-
63
-
-
84946040296
-
Identification of type 2 diabetes subgroups through topological analysis of patient similarity
-
Li, L., Cheng, W.Y., Glicksberg, B.S., et al. Identification of type 2 diabetes subgroups through topological analysis of patient similarity. Sci Transl Med, 7, 2015, 311ra174.
-
(2015)
Sci Transl Med
, vol.7
, pp. 311ra174
-
-
Li, L.1
Cheng, W.Y.2
Glicksberg, B.S.3
-
64
-
-
78549246207
-
Phenomics: the next challenge
-
Houle, D., Govindaraju, D.R., Omholt, S., Phenomics: the next challenge. Nat Rev Genet 11 (2010), 855–866.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 855-866
-
-
Houle, D.1
Govindaraju, D.R.2
Omholt, S.3
-
65
-
-
84880059657
-
The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future
-
Gottesman, O., Kuivaniemi, H., Tromp, G., et al. The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet Med 15 (2013), 761–771.
-
(2013)
Genet Med
, vol.15
, pp. 761-771
-
-
Gottesman, O.1
Kuivaniemi, H.2
Tromp, G.3
-
66
-
-
85034107726
-
-
Electronic Medical Records and Genomics (eMERGE) Network. Available at: Accessed April 23.
-
National Human Genome Research Institute. Electronic Medical Records and Genomics (eMERGE) Network. Available at: https://www.genome.gov/27540473/electronic-medical-records-and-genomics-emerge-network/. Accessed April 23, 2017.
-
(2017)
-
-
National Human Genome Research Institute1
-
67
-
-
85034035094
-
-
PheKB. What is the Phenotype KnowledgeBase? Available at: Accessed April 23
-
PheKB. What is the Phenotype KnowledgeBase? Available at: https://phekb.org. Accessed April 23, 2017.
-
(2017)
-
-
-
68
-
-
84994697920
-
PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability
-
Kirby, J.C., Speltz, P., Rasmussen, L.V., et al. PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability. J Am Med Inform Assoc 23 (2016), 1046–1052.
-
(2016)
J Am Med Inform Assoc
, vol.23
, pp. 1046-1052
-
-
Kirby, J.C.1
Speltz, P.2
Rasmussen, L.V.3
-
69
-
-
84995743962
-
The digital revolution in phenotyping
-
Oellrich, A., Collier, N., Groza, T., et al. The digital revolution in phenotyping. Brief Bioinform 17 (2016), 819–830.
-
(2016)
Brief Bioinform
, vol.17
, pp. 819-830
-
-
Oellrich, A.1
Collier, N.2
Groza, T.3
-
70
-
-
84907284564
-
Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome
-
Zemojtel, T., Kohler, S., Mackenroth, L., et al. Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome. Sci Transl Med, 6, 2014, 252ra123.
-
(2014)
Sci Transl Med
, vol.6
, pp. 252ra123
-
-
Zemojtel, T.1
Kohler, S.2
Mackenroth, L.3
-
71
-
-
84992053162
-
Predictive computational phenotyping and biomarker discovery using reference-free genome comparisons
-
Drouin, A., Giguere, S., Deraspe, M., et al. Predictive computational phenotyping and biomarker discovery using reference-free genome comparisons. BMC Genomics, 17, 2016, 754.
-
(2016)
BMC Genomics
, vol.17
, pp. 754
-
-
Drouin, A.1
Giguere, S.2
Deraspe, M.3
-
72
-
-
84921845885
-
Cost-effectiveness of hypertension therapy according to 2014 guidelines
-
Cost-effectiveness of hypertension therapy according to 2014 guidelines. N Engl J Med, 372, 2015, 1677.
-
(2015)
N Engl J Med
, vol.372
, pp. 1677
-
-
-
73
-
-
84966290897
-
Pleiotropic effects of statins: new therapeutic targets in drug design
-
Bedi, O., Dhawan, V., Sharma, P.L., Kumar, P., Pleiotropic effects of statins: new therapeutic targets in drug design. Naunyn Schmiedebergs Arch Pharmacol 389 (2016), 695–712.
-
(2016)
Naunyn Schmiedebergs Arch Pharmacol
, vol.389
, pp. 695-712
-
-
Bedi, O.1
Dhawan, V.2
Sharma, P.L.3
Kumar, P.4
-
74
-
-
84962541153
-
Pharmacogenetics of lipid-lowering agents: precision or indecision medicine?
-
Alfonsi, J.E., Hegele, R.A., Gryn, S.E., Pharmacogenetics of lipid-lowering agents: precision or indecision medicine?. Curr Atheroscler Rep, 18, 2016, 24.
-
(2016)
Curr Atheroscler Rep
, vol.18
, pp. 24
-
-
Alfonsi, J.E.1
Hegele, R.A.2
Gryn, S.E.3
-
75
-
-
84861230309
-
Pleiotropic effects of statins: the role of eicosanoid production
-
Birnbaum, Y., Ye, Y., Pleiotropic effects of statins: the role of eicosanoid production. Curr Atheroscler Rep 14 (2012), 135–139.
-
(2012)
Curr Atheroscler Rep
, vol.14
, pp. 135-139
-
-
Birnbaum, Y.1
Ye, Y.2
-
76
-
-
84870050309
-
Translating the effects of statins: from redox regulation to suppression of vascular wall inflammation
-
Antonopoulos, A.S., Margaritis, M., Shirodaria, C., Antoniades, C., Translating the effects of statins: from redox regulation to suppression of vascular wall inflammation. Thromb Haemost 108 (2012), 840–848.
-
(2012)
Thromb Haemost
, vol.108
, pp. 840-848
-
-
Antonopoulos, A.S.1
Margaritis, M.2
Shirodaria, C.3
Antoniades, C.4
-
77
-
-
77958541531
-
The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in cardiovascular disease: a comprehensive review
-
Mihos, C.G., Salas, M.J., Santana, O., The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in cardiovascular disease: a comprehensive review. Cardiol Rev 18 (2010), 298–304.
-
(2010)
Cardiol Rev
, vol.18
, pp. 298-304
-
-
Mihos, C.G.1
Salas, M.J.2
Santana, O.3
-
78
-
-
84886925684
-
Predicting the risk of cardiovascular comorbidities in adult cancer survivors
-
Tashakkor, A.Y., Moghaddamjou, A., Chen, L., Cheung, W.Y., Predicting the risk of cardiovascular comorbidities in adult cancer survivors. Curr Oncol 20 (2013), e360–e370.
-
(2013)
Curr Oncol
, vol.20
, pp. e360-e370
-
-
Tashakkor, A.Y.1
Moghaddamjou, A.2
Chen, L.3
Cheung, W.Y.4
-
79
-
-
84954502979
-
Cardiovascular comorbidities relate more than others with disease activity in rheumatoid arthritis
-
Crepaldi, G., Scire, C.A., Carrara, G., et al. Cardiovascular comorbidities relate more than others with disease activity in rheumatoid arthritis. PLoS One, 11, 2016, e0146991.
-
(2016)
PLoS One
, vol.11
, pp. e0146991
-
-
Crepaldi, G.1
Scire, C.A.2
Carrara, G.3
-
80
-
-
39849091350
-
Pathogenesis of essential hypertension: historical paradigms and modern insights
-
Johnson, R.J., Feig, D.I., Nakagawa, T., Sanchez-Lozada, L.G., Rodriguez-Iturbe, B., Pathogenesis of essential hypertension: historical paradigms and modern insights. J Hypertens 26 (2008), 381–391.
-
(2008)
J Hypertens
, vol.26
, pp. 381-391
-
-
Johnson, R.J.1
Feig, D.I.2
Nakagawa, T.3
Sanchez-Lozada, L.G.4
Rodriguez-Iturbe, B.5
-
81
-
-
84987670072
-
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
-
Surendran, P., Drenos, F., Young, R., et al. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet 48 (2016), 1151–1161.
-
(2016)
Nat Genet
, vol.48
, pp. 1151-1161
-
-
Surendran, P.1
Drenos, F.2
Young, R.3
-
82
-
-
84925663443
-
Antihypertensive medication classes used among medicare beneficiaries initiating treatment in 2007–2010
-
Kent, S.T., Shimbo, D., Huang, L., et al. Antihypertensive medication classes used among medicare beneficiaries initiating treatment in 2007–2010. PLoS One, 9, 2014, e105888.
-
(2014)
PLoS One
, vol.9
, pp. e105888
-
-
Kent, S.T.1
Shimbo, D.2
Huang, L.3
-
83
-
-
84908166637
-
The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT)
-
Ambrosius, W.T., Sink, K.M., Foy, C.G., et al. The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT). Clin Trials 11 (2014), 532–546.
-
(2014)
Clin Trials
, vol.11
, pp. 532-546
-
-
Ambrosius, W.T.1
Sink, K.M.2
Foy, C.G.3
-
84
-
-
84893549987
-
2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)
-
James, P.A., Oparil, S., Carter, B.L., et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 311 (2014), 507–520.
-
(2014)
JAMA
, vol.311
, pp. 507-520
-
-
James, P.A.1
Oparil, S.2
Carter, B.L.3
-
85
-
-
84908153218
-
The heterogeneity of heart failure: will enhanced phenotyping be necessary for future clinical trial success?
-
Francis, G.S., Cogswell, R., Thenappan, T., The heterogeneity of heart failure: will enhanced phenotyping be necessary for future clinical trial success?. J Am Coll Cardiol 64 (2014), 1775–1776.
-
(2014)
J Am Coll Cardiol
, vol.64
, pp. 1775-1776
-
-
Francis, G.S.1
Cogswell, R.2
Thenappan, T.3
-
86
-
-
84925353270
-
Systems biology and clinical phenotypes of heart failure syndrome
-
Louridas, G.E., Lourida, K.G., Systems biology and clinical phenotypes of heart failure syndrome. J Am Coll Cardiol 65 (2015), 1269–1270.
-
(2015)
J Am Coll Cardiol
, vol.65
, pp. 1269-1270
-
-
Louridas, G.E.1
Lourida, K.G.2
-
87
-
-
84978842076
-
Heart failure update: diagnosis and classification
-
Eckstein, D., Korabathina, R., Heart failure update: diagnosis and classification. FP Essent 442 (2016), 11–17.
-
(2016)
FP Essent
, vol.442
, pp. 11-17
-
-
Eckstein, D.1
Korabathina, R.2
-
88
-
-
84873098252
-
The disconnect between phase II and phase III trials of drugs for heart failure
-
Vaduganathan, M., Greene, S.J., Ambrosy, A.P., Gheorghiade, M., Butler, J., The disconnect between phase II and phase III trials of drugs for heart failure. Nat Rev Cardiol 10 (2013), 85–97.
-
(2013)
Nat Rev Cardiol
, vol.10
, pp. 85-97
-
-
Vaduganathan, M.1
Greene, S.J.2
Ambrosy, A.P.3
Gheorghiade, M.4
Butler, J.5
-
89
-
-
84969166491
-
Developing new treatments for heart failure: focus on the heart
-
Gheorghiade, M., Larson, C.J., Shah, S.J., et al. Developing new treatments for heart failure: focus on the heart. Circ Heart Fail, 9, 2016.
-
(2016)
Circ Heart Fail
, vol.9
-
-
Gheorghiade, M.1
Larson, C.J.2
Shah, S.J.3
-
90
-
-
84908177699
-
Clinical implications of chronic heart failure phenotypes defined by cluster analysis
-
Ahmad, T., Pencina, M.J., Schulte, P.J., et al. Clinical implications of chronic heart failure phenotypes defined by cluster analysis. J Am Coll Cardiol 64 (2014), 1765–1774.
-
(2014)
J Am Coll Cardiol
, vol.64
, pp. 1765-1774
-
-
Ahmad, T.1
Pencina, M.J.2
Schulte, P.J.3
-
91
-
-
84925355631
-
Applying cluster analysis to data of previously published chronic heart failure trials
-
Madias, J.E., Applying cluster analysis to data of previously published chronic heart failure trials. J Am Coll Cardiol 65 (2015), 1268–1269.
-
(2015)
J Am Coll Cardiol
, vol.65
, pp. 1268-1269
-
-
Madias, J.E.1
-
92
-
-
84925357066
-
Reply: applying cluster analysis to data of previously published chronic heart failure trials: systems biology and clinical phenotypes of heart failure syndrome
-
Ahmad, T., Felker, G.M., Reply: applying cluster analysis to data of previously published chronic heart failure trials: systems biology and clinical phenotypes of heart failure syndrome. J Am Coll Cardiol 65 (2015), 1270–1271.
-
(2015)
J Am Coll Cardiol
, vol.65
, pp. 1270-1271
-
-
Ahmad, T.1
Felker, G.M.2
-
93
-
-
84861759937
-
Modern management of acute myocardial infarction
-
Welch, T.D., Yang, E.H., Reeder, G.S., Gersh, B.J., Modern management of acute myocardial infarction. Curr Probl Cardiol 37 (2012), 237–310.
-
(2012)
Curr Probl Cardiol
, vol.37
, pp. 237-310
-
-
Welch, T.D.1
Yang, E.H.2
Reeder, G.S.3
Gersh, B.J.4
-
94
-
-
84959268154
-
Cross-tissue regulatory gene networks in coronary artery disease
-
Talukdar, H.A., Foroughi Asl, H., Jain, R.K., et al. Cross-tissue regulatory gene networks in coronary artery disease. Cell Syst 2 (2016), 196–208.
-
(2016)
Cell Syst
, vol.2
, pp. 196-208
-
-
Talukdar, H.A.1
Foroughi Asl, H.2
Jain, R.K.3
-
95
-
-
84983472699
-
Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases
-
Franzen, O., Ermel, R., Cohain, A., et al. Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases. Science 353 (2016), 827–830.
-
(2016)
Science
, vol.353
, pp. 827-830
-
-
Franzen, O.1
Ermel, R.2
Cohain, A.3
-
96
-
-
84929377932
-
Back to the future: improving the use of guidelines-recommended coronary disease secondary prevention at the dawn of the precision medicine era
-
Rymer, J.A., Newby, L.K., Back to the future: improving the use of guidelines-recommended coronary disease secondary prevention at the dawn of the precision medicine era. Circulation 131 (2015), 1234–1235.
-
(2015)
Circulation
, vol.131
, pp. 1234-1235
-
-
Rymer, J.A.1
Newby, L.K.2
-
97
-
-
84941056057
-
The emergence of cardiovascular imaging as a subspecialty and individualized treatment of coronary artery disease: two related trends
-
Shurlock, B., The emergence of cardiovascular imaging as a subspecialty and individualized treatment of coronary artery disease: two related trends. Eur Heart J 35 (2014), 3392–3393.
-
(2014)
Eur Heart J
, vol.35
, pp. 3392-3393
-
-
Shurlock, B.1
-
98
-
-
84924143281
-
Biomarkers of coronary artery disease differ between Asians and Caucasians in the general population
-
Gijsberts, C.M., den Ruijter, H.M., Asselbergs, F.W., Chan, M.Y., de Kleijn, D.P., Hoefer, I.E., Biomarkers of coronary artery disease differ between Asians and Caucasians in the general population. Glob Heart 10 (2015), 301–311.e11.
-
(2015)
Glob Heart
, vol.10
, pp. 301-311.e11
-
-
Gijsberts, C.M.1
den Ruijter, H.M.2
Asselbergs, F.W.3
Chan, M.Y.4
de Kleijn, D.P.5
Hoefer, I.E.6
-
99
-
-
84904282289
-
Evolving biomarkers improve prediction of long-term mortality in patients with stable coronary artery disease: the BIO-VILCAD score
-
Kleber, M.E., Goliasch, G., Grammer, T.B., et al. Evolving biomarkers improve prediction of long-term mortality in patients with stable coronary artery disease: the BIO-VILCAD score. J Intern Med 276 (2014), 184–194.
-
(2014)
J Intern Med
, vol.276
, pp. 184-194
-
-
Kleber, M.E.1
Goliasch, G.2
Grammer, T.B.3
-
100
-
-
84984905354
-
The role of serum levels of microRNA-21 and matrix metalloproteinase-9 in patients with acute coronary syndrome
-
Darabi, F., Aghaei, M., Movahedian, A., Pourmoghadas, A., Sarrafzadegan, N., The role of serum levels of microRNA-21 and matrix metalloproteinase-9 in patients with acute coronary syndrome. Mol Cell Biochem 422 (2016), 51–60.
-
(2016)
Mol Cell Biochem
, vol.422
, pp. 51-60
-
-
Darabi, F.1
Aghaei, M.2
Movahedian, A.3
Pourmoghadas, A.4
Sarrafzadegan, N.5
-
101
-
-
84984869267
-
Association of soluble fibrinogen-like protein 2 with the severity of coronary artery disease
-
Cheng, J., Chen, Y., Xu, B., Wu, J., He, F., Association of soluble fibrinogen-like protein 2 with the severity of coronary artery disease. Intern Med 55 (2016), 2343–2350.
-
(2016)
Intern Med
, vol.55
, pp. 2343-2350
-
-
Cheng, J.1
Chen, Y.2
Xu, B.3
Wu, J.4
He, F.5
-
102
-
-
84988383522
-
Serum levels of mitochondrial inhibitory factor 1 are independently associated with long-term prognosis in coronary artery disease: the GENES Study
-
Genoux, A., Lichtenstein, L., Ferrieres, J., et al. Serum levels of mitochondrial inhibitory factor 1 are independently associated with long-term prognosis in coronary artery disease: the GENES Study. BMC Med, 14, 2016, 125.
-
(2016)
BMC Med
, vol.14
, pp. 125
-
-
Genoux, A.1
Lichtenstein, L.2
Ferrieres, J.3
-
103
-
-
85000716796
-
The impact of biochemical markers on major adverse cardiovascular events and contralateral carotid artery stenosis progression following carotid interventions
-
Stone, P.A., Thompson, S.N., Khan, M., Northfield, E., Schillinger, R., Skaff, P., The impact of biochemical markers on major adverse cardiovascular events and contralateral carotid artery stenosis progression following carotid interventions. Ann Vasc Surg 38 (2017), 144–150.
-
(2017)
Ann Vasc Surg
, vol.38
, pp. 144-150
-
-
Stone, P.A.1
Thompson, S.N.2
Khan, M.3
Northfield, E.4
Schillinger, R.5
Skaff, P.6
-
104
-
-
84981501479
-
Plasma microRNA-126-5p is associated with the complexity and severity of coronary artery disease in patients with stable angina pectoris
-
Li, H.Y., Zhao, X., Liu, Y.Z., et al. Plasma microRNA-126-5p is associated with the complexity and severity of coronary artery disease in patients with stable angina pectoris. Cell Physiol Biochem 39 (2016), 837–846.
-
(2016)
Cell Physiol Biochem
, vol.39
, pp. 837-846
-
-
Li, H.Y.1
Zhao, X.2
Liu, Y.Z.3
-
105
-
-
0742305866
-
Network biology: understanding the cell's functional organization
-
Barabasi, A.L., Oltvai, Z.N., Network biology: understanding the cell's functional organization. Nat Rev Genet 5 (2004), 101–113.
-
(2004)
Nat Rev Genet
, vol.5
, pp. 101-113
-
-
Barabasi, A.L.1
Oltvai, Z.N.2
-
106
-
-
84902649945
-
Understanding protein-nanoparticle interaction: a new gateway to disease therapeutics
-
Giri, K., Shameer, K., Zimmermann, M.T., et al. Understanding protein-nanoparticle interaction: a new gateway to disease therapeutics. Bioconjug Chem 25 (2014), 1078–1090.
-
(2014)
Bioconjug Chem
, vol.25
, pp. 1078-1090
-
-
Giri, K.1
Shameer, K.2
Zimmermann, M.T.3
-
107
-
-
84872461605
-
Social network analysis: foundations and frontiers on advantage
-
Burt, R.S., Kilduff, M., Tasselli, S., Social network analysis: foundations and frontiers on advantage. Annu Rev Psychol 64 (2013), 527–547.
-
(2013)
Annu Rev Psychol
, vol.64
, pp. 527-547
-
-
Burt, R.S.1
Kilduff, M.2
Tasselli, S.3
-
108
-
-
79952674000
-
Interactome networks and human disease
-
Vidal, M., Cusick, M.E., Barabasi, A.L., Interactome networks and human disease. Cell 144 (2011), 986–998.
-
(2011)
Cell
, vol.144
, pp. 986-998
-
-
Vidal, M.1
Cusick, M.E.2
Barabasi, A.L.3
-
109
-
-
84971212642
-
An integrative pipeline for multi-modal discovery of disease relationships
-
Glicksberg, B.S., Li, L., Cheng, W.Y., et al. An integrative pipeline for multi-modal discovery of disease relationships. Pac Symp Biocomput, 2015, 407–418.
-
(2015)
Pac Symp Biocomput
, pp. 407-418
-
-
Glicksberg, B.S.1
Li, L.2
Cheng, W.Y.3
-
110
-
-
84976480079
-
Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks
-
Glicksberg, B.S., Li, L., Badgeley, M.A., et al. Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks. Bioinformatics 32 (2016), i101–i110.
-
(2016)
Bioinformatics
, vol.32
, pp. i101-i110
-
-
Glicksberg, B.S.1
Li, L.2
Badgeley, M.A.3
-
111
-
-
84876888105
-
Challenges and opportunities of drug repositioning
-
Novac, N., Challenges and opportunities of drug repositioning. Trends Pharmacol Sci 34 (2013), 267–272.
-
(2013)
Trends Pharmacol Sci
, vol.34
, pp. 267-272
-
-
Novac, N.1
-
112
-
-
84867338003
-
Discovery and preclinical validation of drug indications using compendia of public gene expression data
-
Sirota, M., Dudley, J.T., Kim, J., et al. Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Transl Med, 3, 2011, 96ra77.
-
(2011)
Sci Transl Med
, vol.3
, pp. 96ra77
-
-
Sirota, M.1
Dudley, J.T.2
Kim, J.3
-
113
-
-
84922285922
-
Computational and experimental advances in drug repositioning for accelerated therapeutic stratification
-
Shameer, K., Readhead, B., Dudley, J.T., Computational and experimental advances in drug repositioning for accelerated therapeutic stratification. Curr Top Med Chem 15 (2015), 5–20.
-
(2015)
Curr Top Med Chem
, vol.15
, pp. 5-20
-
-
Shameer, K.1
Readhead, B.2
Dudley, J.T.3
-
114
-
-
85034053171
-
-
RepurposeDB. Repositioning investigations. Available at: Accessed April 23
-
RepurposeDB. Repositioning investigations. Available at: http://repurposedb.dudleylab.org/. Accessed April 23, 2017.
-
(2017)
-
-
-
115
-
-
0029937949
-
The effect of carvedilol on morbidity and mortality in patients with chronic heart failure
-
Packer, M., Bristow, M.R., Cohn, J.N., et al., for the U.S. Carvedilol Heart Failure Study Group. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med 334 (1996), 1349–1355.
-
(1996)
N Engl J Med
, vol.334
, pp. 1349-1355
-
-
Packer, M.1
Bristow, M.R.2
Cohn, J.N.3
-
116
-
-
0018759507
-
Prolongation of survival in congestive cardiomyopathy by beta-receptor blockade
-
Swedberg, K., Hjalmarson, A., Waagstein, F., Wallentin, I., Prolongation of survival in congestive cardiomyopathy by beta-receptor blockade. Lancet 1 (1979), 1374–1376.
-
(1979)
Lancet
, vol.1
, pp. 1374-1376
-
-
Swedberg, K.1
Hjalmarson, A.2
Waagstein, F.3
Wallentin, I.4
-
117
-
-
0013932912
-
The effect of beta adrenergic blockade on patterns of urinary sodium excretion. Studies in normal subjects and in patients with heart disease
-
Epstein, S.E., Braunwald, E., The effect of beta adrenergic blockade on patterns of urinary sodium excretion. Studies in normal subjects and in patients with heart disease. Ann Intern Med 65 (1966), 20–27.
-
(1966)
Ann Intern Med
, vol.65
, pp. 20-27
-
-
Epstein, S.E.1
Braunwald, E.2
-
118
-
-
0031951754
-
Cyclic-GMP-binding, cyclic-GMP-specific phosphodiesterase (PDE5) gene expression is regulated during rat pulmonary development
-
Sanchez, L.S., de la Monte, S.M., Filippov, G., Jones, R.C., Zapol, W.M., Bloch, K.D., Cyclic-GMP-binding, cyclic-GMP-specific phosphodiesterase (PDE5) gene expression is regulated during rat pulmonary development. Pediatr Res 43 (1998), 163–168.
-
(1998)
Pediatr Res
, vol.43
, pp. 163-168
-
-
Sanchez, L.S.1
de la Monte, S.M.2
Filippov, G.3
Jones, R.C.4
Zapol, W.M.5
Bloch, K.D.6
-
119
-
-
33846911349
-
Sildenafil in the treatment of pulmonary hypertension
-
Barnett, C.F., Machado, R.F., Sildenafil in the treatment of pulmonary hypertension. Vasc Health Risk Manag 2 (2006), 411–422.
-
(2006)
Vasc Health Risk Manag
, vol.2
, pp. 411-422
-
-
Barnett, C.F.1
Machado, R.F.2
-
120
-
-
33746584053
-
Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
-
Ghofrani, H.A., Osterloh, I.H., Grimminger, F., Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat Rev Drug Discov 5 (2006), 689–702.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 689-702
-
-
Ghofrani, H.A.1
Osterloh, I.H.2
Grimminger, F.3
-
121
-
-
84948382896
-
Drug repurposing in oncology—patient and health systems opportunities
-
Bertolini, F., Sukhatme, V.P., Bouche, G., Drug repurposing in oncology—patient and health systems opportunities. Nat Rev Clin Oncol 12 (2015), 732–742.
-
(2015)
Nat Rev Clin Oncol
, vol.12
, pp. 732-742
-
-
Bertolini, F.1
Sukhatme, V.P.2
Bouche, G.3
-
122
-
-
84887174474
-
Colchicine and the heart: pushing the envelope
-
Deftereos, S., Giannopoulos, G., Papoutsidakis, N., et al. Colchicine and the heart: pushing the envelope. J Am Coll Cardiol 62 (2013), 1817–1825.
-
(2013)
J Am Coll Cardiol
, vol.62
, pp. 1817-1825
-
-
Deftereos, S.1
Giannopoulos, G.2
Papoutsidakis, N.3
-
123
-
-
84948383442
-
Systems biology approaches to adverse drug effects: the example of cardio-oncology
-
Brown, S.A., Sandhu, N., Herrmann, J., Systems biology approaches to adverse drug effects: the example of cardio-oncology. Nat Rev Clin Oncol 12 (2015), 718–731.
-
(2015)
Nat Rev Clin Oncol
, vol.12
, pp. 718-731
-
-
Brown, S.A.1
Sandhu, N.2
Herrmann, J.3
-
124
-
-
85034082605
-
-
RepurposeDB. Drugs. Available at: Accessed April 23
-
RepurposeDB. Drugs. Available at: http://repurposedb.dudleylab.org/browseDrugs. Accessed April 23, 2017.
-
(2017)
-
-
-
125
-
-
84896691663
-
Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer
-
Bharadwaj, U., Eckols, T.K., Kolosov, M., et al. Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Oncogene 34 (2015), 1341–1353.
-
(2015)
Oncogene
, vol.34
, pp. 1341-1353
-
-
Bharadwaj, U.1
Eckols, T.K.2
Kolosov, M.3
-
126
-
-
84868379118
-
Drug repositioning for Alzheimer's disease
-
Corbett, A., Pickett, J., Burns, A., et al. Drug repositioning for Alzheimer's disease. Nat Rev Drug Discov 11 (2012), 833–846.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 833-846
-
-
Corbett, A.1
Pickett, J.2
Burns, A.3
-
127
-
-
84904718484
-
Pharmaco-miR: linking microRNAs and drug effects
-
Rukov, J.L., Wilentzik, R., Jaffe, I., Vinther, J., Shomron, N., Pharmaco-miR: linking microRNAs and drug effects. Brief Bioinform 15 (2014), 648–659.
-
(2014)
Brief Bioinform
, vol.15
, pp. 648-659
-
-
Rukov, J.L.1
Wilentzik, R.2
Jaffe, I.3
Vinther, J.4
Shomron, N.5
-
128
-
-
33645452696
-
Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application
-
Millan, M.J., Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther 110 (2006), 135–370.
-
(2006)
Pharmacol Ther
, vol.110
, pp. 135-370
-
-
Millan, M.J.1
-
129
-
-
84863085673
-
Multi-target drugs: the trend of drug research and development
-
Lu, J.J., Pan, W., Hu, Y.J., Wang, Y.T., Multi-target drugs: the trend of drug research and development. PLoS One, 7, 2012, e40262.
-
(2012)
PLoS One
, vol.7
, pp. e40262
-
-
Lu, J.J.1
Pan, W.2
Hu, Y.J.3
Wang, Y.T.4
-
130
-
-
33845762340
-
Multi-target therapeutics: when the whole is greater than the sum of the parts
-
Zimmermann, G.R., Lehar, J., Keith, C.T., Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today 12 (2007), 34–42.
-
(2007)
Drug Discov Today
, vol.12
, pp. 34-42
-
-
Zimmermann, G.R.1
Lehar, J.2
Keith, C.T.3
-
131
-
-
84876933802
-
Shifting from the single to the multitarget paradigm in drug discovery
-
Medina-Franco, J.L., Giulianotti, M.A., Welmaker, G.S., Houghten, R.A., Shifting from the single to the multitarget paradigm in drug discovery. Drug Discov Today 18 (2013), 495–501.
-
(2013)
Drug Discov Today
, vol.18
, pp. 495-501
-
-
Medina-Franco, J.L.1
Giulianotti, M.A.2
Welmaker, G.S.3
Houghten, R.A.4
-
132
-
-
0037463683
-
Trimethoprim-sulfamethoxazole revisited
-
Masters, P.A., O'Bryan, T.A., Zurlo, J., Miller, D.Q., Joshi, N., Trimethoprim-sulfamethoxazole revisited. Arch Intern Med 163 (2003), 402–410.
-
(2003)
Arch Intern Med
, vol.163
, pp. 402-410
-
-
Masters, P.A.1
O'Bryan, T.A.2
Zurlo, J.3
Miller, D.Q.4
Joshi, N.5
-
133
-
-
0035153910
-
Quinupristin/dalfopristin: a therapeutic review
-
Allington, D.R., Rivey, M.P., Quinupristin/dalfopristin: a therapeutic review. Clin Ther 23 (2001), 24–44.
-
(2001)
Clin Ther
, vol.23
, pp. 24-44
-
-
Allington, D.R.1
Rivey, M.P.2
-
134
-
-
54249155522
-
Network pharmacology: the next paradigm in drug discovery
-
Hopkins, A.L., Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 4 (2008), 682–690.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 682-690
-
-
Hopkins, A.L.1
-
135
-
-
79952444246
-
Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association
-
Heidenreich, P.A., Trogdon, J.G., Khavjou, O.A., et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation 123 (2011), 933–944.
-
(2011)
Circulation
, vol.123
, pp. 933-944
-
-
Heidenreich, P.A.1
Trogdon, J.G.2
Khavjou, O.A.3
-
136
-
-
84906233173
-
The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study
-
Kullo, I.J., Shameer, K., Jouni, H., et al. The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study. Front Genet, 5, 2014, 166.
-
(2014)
Front Genet
, vol.5
, pp. 166
-
-
Kullo, I.J.1
Shameer, K.2
Jouni, H.3
-
137
-
-
4444382796
-
Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case- control study
-
Yusuf, S., Hawken, S., Ounpuu, S., et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case- control study. Lancet 364 (2004), 937–952.
-
(2004)
Lancet
, vol.364
, pp. 937-952
-
-
Yusuf, S.1
Hawken, S.2
Ounpuu, S.3
-
138
-
-
0037118660
-
AHA guidelines for primary prevention of cardiovascular disease and stroke: 2002 update: consensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases. American Heart Association Science Advisory and Coordinating Committee
-
Pearson, T.A., Blair, S.N., Daniels, S.R., et al. AHA guidelines for primary prevention of cardiovascular disease and stroke: 2002 update: consensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases. American Heart Association Science Advisory and Coordinating Committee. Circulation 106 (2002), 388–391.
-
(2002)
Circulation
, vol.106
, pp. 388-391
-
-
Pearson, T.A.1
Blair, S.N.2
Daniels, S.R.3
-
139
-
-
85034067075
-
-
cBioPortal for Cancer Genomics. Available at: Accessed April 23
-
cBioPortal for Cancer Genomics. Available at: http://www.cbioportal.org/. Accessed April 23, 2017.
-
(2017)
-
-
-
140
-
-
84866002291
-
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
-
Cerami, E., Gao, J., Dogrusoz, U., et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2 (2012), 401–404.
-
(2012)
Cancer Discov
, vol.2
, pp. 401-404
-
-
Cerami, E.1
Gao, J.2
Dogrusoz, U.3
-
141
-
-
84924312533
-
The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data
-
Tang, X., Baheti, S., Shameer, K., et al. The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data. Nucleic Acids Res, 42, 2014, e172.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. e172
-
-
Tang, X.1
Baheti, S.2
Shameer, K.3
-
142
-
-
84964643047
-
The US Cancer Moonshot initiative
-
Aelion, C.M., Airhihenbuwa, C.O., Alemagno, S., et al. The US Cancer Moonshot initiative. Lancet Oncol 17 (2016), e178–e180.
-
(2016)
Lancet Oncol
, vol.17
, pp. e178-e180
-
-
Aelion, C.M.1
Airhihenbuwa, C.O.2
Alemagno, S.3
-
143
-
-
84979041873
-
Oncology nurses and the Cancer Moonshot 2020
-
Kennedy Sheldon, L., Oncology nurses and the Cancer Moonshot 2020. Clin J Oncol Nurs 20 (2016), 355–356.
-
(2016)
Clin J Oncol Nurs
, vol.20
, pp. 355-356
-
-
Kennedy Sheldon, L.1
-
144
-
-
85034055060
-
-
News. ‘1 Team, 1 Vision’—AHA, Google Life Sciences launch $50 million project. Available at: Accessed April 23
-
American Heart Association News. ‘1 Team, 1 Vision’—AHA, Google Life Sciences launch $50 million project. Available at: http://news.heart.org/american-heart-association-google-life-sciences-seeking-novel-strategies-to-prevent-heart-disease/. Accessed April 23, 2017.
-
(2017)
-
-
American Heart Association1
-
145
-
-
84939542491
-
Cardiovascular precision medicine: hope or hype?
-
Pitt, G.S., Cardiovascular precision medicine: hope or hype?. Eur Heart J 36 (2015), 1842–1843.
-
(2015)
Eur Heart J
, vol.36
, pp. 1842-1843
-
-
Pitt, G.S.1
-
146
-
-
84962090118
-
Medical student preparedness for an era of personalized medicine: findings from one US medical school
-
Eden, C., Johnson, K.W., Gottesman, O., Bottinger, E.P., Abul-Husn, N.S., Medical student preparedness for an era of personalized medicine: findings from one US medical school. Per Med 13 (2016), 129–141.
-
(2016)
Per Med
, vol.13
, pp. 129-141
-
-
Eden, C.1
Johnson, K.W.2
Gottesman, O.3
Bottinger, E.P.4
Abul-Husn, N.S.5
-
147
-
-
0242412914
-
Bioinformatics and medical informatics: collaborations on the road to genomic medicine?
-
Maojo, V., Kulikowski, C.A., Bioinformatics and medical informatics: collaborations on the road to genomic medicine?. J Am Med Inform Assoc 10 (2003), 515–522.
-
(2003)
J Am Med Inform Assoc
, vol.10
, pp. 515-522
-
-
Maojo, V.1
Kulikowski, C.A.2
-
148
-
-
0032489974
-
Healthcare and the information age: implications for medical education
-
Carlile, S., Sefton, A.J., Healthcare and the information age: implications for medical education. Med J Aust 168 (1998), 340–343.
-
(1998)
Med J Aust
, vol.168
, pp. 340-343
-
-
Carlile, S.1
Sefton, A.J.2
-
149
-
-
84962218879
-
EHDViz: clinical dashboard development using open-source technologies
-
Badgeley, M.A., Shameer, K., Glicksberg, B.S., et al. EHDViz: clinical dashboard development using open-source technologies. BMJ Open, 6, 2016, e010579.
-
(2016)
BMJ Open
, vol.6
, pp. e010579
-
-
Badgeley, M.A.1
Shameer, K.2
Glicksberg, B.S.3
-
150
-
-
84912093496
-
Visual analytics in healthcare education: exploring novel ways to analyze and represent big data in undergraduate medical education
-
Vaitsis, C., Nilsson, G., Zary, N., Visual analytics in healthcare education: exploring novel ways to analyze and represent big data in undergraduate medical education. PeerJ, 2, 2014, e683.
-
(2014)
PeerJ
, vol.2
, pp. e683
-
-
Vaitsis, C.1
Nilsson, G.2
Zary, N.3
-
151
-
-
0031023489
-
Shared decision-making in the medical encounter: what does it mean? (or it takes at least two to tango)
-
Charles, C., Gafni, A., Whelan, T., Shared decision-making in the medical encounter: what does it mean? (or it takes at least two to tango). Soc Sci Med 44 (1997), 681–692.
-
(1997)
Soc Sci Med
, vol.44
, pp. 681-692
-
-
Charles, C.1
Gafni, A.2
Whelan, T.3
-
152
-
-
84961393205
-
Big data analytics to improve cardiovascular care: promise and challenges
-
Rumsfeld, J.S., Joynt, K.E., Maddox, T.M., Big data analytics to improve cardiovascular care: promise and challenges. Nat Rev Cardiol 13 (2016), 350–359.
-
(2016)
Nat Rev Cardiol
, vol.13
, pp. 350-359
-
-
Rumsfeld, J.S.1
Joynt, K.E.2
Maddox, T.M.3
-
153
-
-
73349096011
-
An electronic clinical decision support tool to assist primary care providers in cardiovascular disease risk management: development and mixed methods evaluation
-
Peiris, D.P., Joshi, R., Webster, R.J., et al. An electronic clinical decision support tool to assist primary care providers in cardiovascular disease risk management: development and mixed methods evaluation. J Med Internet Res, 11, 2009, e51.
-
(2009)
J Med Internet Res
, vol.11
, pp. e51
-
-
Peiris, D.P.1
Joshi, R.2
Webster, R.J.3
-
154
-
-
80053986227
-
Pharmacogenetics and cost-effectiveness analysis: a two-way street
-
Chalkidou, K., Rawlins, M., Pharmacogenetics and cost-effectiveness analysis: a two-way street. Drug Discov Today 16 (2011), 873–877.
-
(2011)
Drug Discov Today
, vol.16
, pp. 873-877
-
-
Chalkidou, K.1
Rawlins, M.2
-
155
-
-
84893797996
-
Cost-effectiveness of pharmacogenetics- guided warfarin therapy vs. alternative anticoagulation in atrial fibrillation
-
Pink, J., Pirmohamed, M., Lane, S., Hughes, D.A., Cost-effectiveness of pharmacogenetics- guided warfarin therapy vs. alternative anticoagulation in atrial fibrillation. Clin Pharmacol Ther 95 (2014), 199–207.
-
(2014)
Clin Pharmacol Ther
, vol.95
, pp. 199-207
-
-
Pink, J.1
Pirmohamed, M.2
Lane, S.3
Hughes, D.A.4
-
156
-
-
84976262193
-
Cost-effectiveness of pharmacogenetic- guided dosing of warfarin in the United Kingdom and Sweden
-
Verhoef, T.I., Redekop, W.K., Langenskiold, S., et al. Cost-effectiveness of pharmacogenetic- guided dosing of warfarin in the United Kingdom and Sweden. Pharmacogenomics J 16 (2016), 478–484.
-
(2016)
Pharmacogenomics J
, vol.16
, pp. 478-484
-
-
Verhoef, T.I.1
Redekop, W.K.2
Langenskiold, S.3
-
157
-
-
85034050677
-
Cost-effectiveness of a novel pharmacist guided warfarin pharmacogenetic service
-
Gor, D., Kim, K., Chumnumwat, S., et al. Cost-effectiveness of a novel pharmacist guided warfarin pharmacogenetic service. Value Health, 18, 2015, A390.
-
(2015)
Value Health
, vol.18
, pp. A390
-
-
Gor, D.1
Kim, K.2
Chumnumwat, S.3
-
158
-
-
84891030619
-
Pharmacogenetic-guided selection of warfarin versus novel oral anticoagulants for stroke prevention in patients with atrial fibrillation: a cost-effectiveness analysis
-
You, J.H., Pharmacogenetic-guided selection of warfarin versus novel oral anticoagulants for stroke prevention in patients with atrial fibrillation: a cost-effectiveness analysis. Pharmacogenet Genomics 24 (2014), 6–14.
-
(2014)
Pharmacogenet Genomics
, vol.24
, pp. 6-14
-
-
You, J.H.1
-
159
-
-
84976871516
-
GWASdb v2: an update database for human genetic variants identified by genome-wide association studies
-
Li, M.J., Liu, Z., Wang, P., et al. GWASdb v2: an update database for human genetic variants identified by genome-wide association studies. Nucleic Acids Res 44 (2016), D869–D876.
-
(2016)
Nucleic Acids Res
, vol.44
, pp. D869-D876
-
-
Li, M.J.1
Liu, Z.2
Wang, P.3
|