메뉴 건너뛰기




Volumn 2, Issue 3, 2017, Pages 311-327

Enabling Precision Cardiology Through Multiscale Biology and Systems Medicine

Author keywords

cardiology; clinical informatics; multi omics; precision medicine; translational bioinformatics

Indexed keywords


EID: 85033597806     PISSN: 2452302X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacbts.2016.11.010     Document Type: Review
Times cited : (66)

References (159)
  • 1
    • 84878821943 scopus 로고    scopus 로고
    • Coronary stents: historical development, current status and future directions
    • Iqbal, J., Gunn, J., Serruys, P.W., Coronary stents: historical development, current status and future directions. Br Med Bull 106 (2013), 193–211.
    • (2013) Br Med Bull , vol.106 , pp. 193-211
    • Iqbal, J.1    Gunn, J.2    Serruys, P.W.3
  • 2
    • 0025881724 scopus 로고
    • History of the design of captopril and related inhibitors of angiotensin converting enzyme
    • Cushman, D.W., Ondetti, M.A., History of the design of captopril and related inhibitors of angiotensin converting enzyme. Hypertension 17 (1991), 589–592.
    • (1991) Hypertension , vol.17 , pp. 589-592
    • Cushman, D.W.1    Ondetti, M.A.2
  • 3
    • 34247854930 scopus 로고    scopus 로고
    • Decline in rates of death and heart failure in acute coronary syndromes, 1999–2006
    • Fox, K.A., Steg, P.G., Eagle, K.A., et al. Decline in rates of death and heart failure in acute coronary syndromes, 1999–2006. JAMA 297 (2007), 1892–1900.
    • (2007) JAMA , vol.297 , pp. 1892-1900
    • Fox, K.A.1    Steg, P.G.2    Eagle, K.A.3
  • 4
    • 40949131340 scopus 로고    scopus 로고
    • Medication nonadherence is associated with a broad range of adverse outcomes in patients with coronary artery disease
    • Ho, P.M., Magid, D.J., Shetterly, S.M., et al. Medication nonadherence is associated with a broad range of adverse outcomes in patients with coronary artery disease. Am Heart J 155 (2008), 772–779.
    • (2008) Am Heart J , vol.155 , pp. 772-779
    • Ho, P.M.1    Magid, D.J.2    Shetterly, S.M.3
  • 5
    • 85013228246 scopus 로고    scopus 로고
    • Recent trends in cardiovascular mortality in the United States and public health goals
    • Sidney, S., Quesenberry, C.P. Jr., Jaffe, M.G., et al. Recent trends in cardiovascular mortality in the United States and public health goals. JAMA Cardiol 1 (2016), 594–599.
    • (2016) JAMA Cardiol , vol.1 , pp. 594-599
    • Sidney, S.1    Quesenberry, C.P.2    Jaffe, M.G.3
  • 6
    • 84937968994 scopus 로고    scopus 로고
    • Genome-wide association studies of late-onset cardiovascular disease
    • Smith, J.G., Newton-Cheh, C., Genome-wide association studies of late-onset cardiovascular disease. J Mol Cell Cardiol 83 (2015), 131–141.
    • (2015) J Mol Cell Cardiol , vol.83 , pp. 131-141
    • Smith, J.G.1    Newton-Cheh, C.2
  • 7
    • 84977636037 scopus 로고    scopus 로고
    • The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease
    • Kessler, T., Vilne, B., Schunkert, H., The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease. EMBO Mol Med 8 (2016), 688–701.
    • (2016) EMBO Mol Med , vol.8 , pp. 688-701
    • Kessler, T.1    Vilne, B.2    Schunkert, H.3
  • 9
    • 84960891322 scopus 로고    scopus 로고
    • Genetic loci associated with ideal cardiovascular health: a meta-analysis of genome-wide association studies
    • Allen, N.B., Lloyd-Jones, D., Hwang, S.J., et al. Genetic loci associated with ideal cardiovascular health: a meta-analysis of genome-wide association studies. Am Heart J 175 (2016), 112–120.
    • (2016) Am Heart J , vol.175 , pp. 112-120
    • Allen, N.B.1    Lloyd-Jones, D.2    Hwang, S.J.3
  • 11
    • 84923342405 scopus 로고    scopus 로고
    • Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders
    • Bjorkegren, J.L., Kovacic, J.C., Dudley, J.T., Schadt, E.E., Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders. J Am Coll Cardiol 65 (2015), 830–845.
    • (2015) J Am Coll Cardiol , vol.65 , pp. 830-845
    • Bjorkegren, J.L.1    Kovacic, J.C.2    Dudley, J.T.3    Schadt, E.E.4
  • 12
    • 84891858260 scopus 로고    scopus 로고
    • A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects
    • Shameer, K., Denny, J.C., Ding, K., et al. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. Hum Genet 133 (2014), 95–109.
    • (2014) Hum Genet , vol.133 , pp. 95-109
    • Shameer, K.1    Denny, J.C.2    Ding, K.3
  • 13
    • 0035204617 scopus 로고    scopus 로고
    • Realism in drug discovery—could Cassandra be right?
    • Horrobin, D.F., Realism in drug discovery—could Cassandra be right?. Nat Biotechnol 19 (2001), 1099–1100.
    • (2001) Nat Biotechnol , vol.19 , pp. 1099-1100
    • Horrobin, D.F.1
  • 15
    • 84928036813 scopus 로고    scopus 로고
    • Cardiovascular drug development: is it dead or just hibernating?
    • Fordyce, C.B., Roe, M.T., Ahmad, T., et al. Cardiovascular drug development: is it dead or just hibernating?. J Am Coll Cardiol 65 (2015), 1567–1582.
    • (2015) J Am Coll Cardiol , vol.65 , pp. 1567-1582
    • Fordyce, C.B.1    Roe, M.T.2    Ahmad, T.3
  • 16
    • 48149083115 scopus 로고    scopus 로고
    • The failure of torcetrapib: what have we learned?
    • Joy, T.R., Hegele, R.A., The failure of torcetrapib: what have we learned?. Br J Pharmacol 154 (2008), 1379–1381.
    • (2008) Br J Pharmacol , vol.154 , pp. 1379-1381
    • Joy, T.R.1    Hegele, R.A.2
  • 17
    • 84987854661 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein inhibitors: trials and tribulations
    • [E-pub ahead of print]
    • McLain, J.H., Alsterda, A.J., Arora, R.R., Cholesteryl ester transfer protein inhibitors: trials and tribulations. J Cardiovasc Pharmacol Ther, 2016 Aug 10 [E-pub ahead of print].
    • (2016) J Cardiovasc Pharmacol Ther
    • McLain, J.H.1    Alsterda, A.J.2    Arora, R.R.3
  • 18
    • 84959569935 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein inhibition is not yet dead—pro
    • Barter, P.J., Rye, K.A., Cholesteryl ester transfer protein inhibition is not yet dead—pro. Arterioscler Thromb Vasc Biol 36 (2016), 439–441.
    • (2016) Arterioscler Thromb Vasc Biol , vol.36 , pp. 439-441
    • Barter, P.J.1    Rye, K.A.2
  • 19
    • 84887963766 scopus 로고    scopus 로고
    • Network medicine in disease analysis and therapeutics
    • Chen, B., Butte, A.J., Network medicine in disease analysis and therapeutics. Clin Pharmacol Ther 94 (2013), 627–629.
    • (2013) Clin Pharmacol Ther , vol.94 , pp. 627-629
    • Chen, B.1    Butte, A.J.2
  • 21
    • 84976448008 scopus 로고    scopus 로고
    • Precision medicine in cardiology
    • Antman, E.M., Loscalzo, J., Precision medicine in cardiology. Nat Rev Cardiol 13 (2016), 591–602.
    • (2016) Nat Rev Cardiol , vol.13 , pp. 591-602
    • Antman, E.M.1    Loscalzo, J.2
  • 22
    • 84961377536 scopus 로고    scopus 로고
    • Opportunities for the cardiovascular community in the precision medicine initiative
    • Shah, S.H., Arnett, D., Houser, S.R., et al. Opportunities for the cardiovascular community in the precision medicine initiative. Circulation 133 (2016), 226–231.
    • (2016) Circulation , vol.133 , pp. 226-231
    • Shah, S.H.1    Arnett, D.2    Houser, S.R.3
  • 23
    • 84931427223 scopus 로고    scopus 로고
    • Planning for US Precision Medicine Initiative underway
    • Jaffe, S., Planning for US Precision Medicine Initiative underway. Lancet 385 (2015), 2448–2449.
    • (2015) Lancet , vol.385 , pp. 2448-2449
    • Jaffe, S.1
  • 24
    • 84930439209 scopus 로고    scopus 로고
    • The precision medicine initiative: a new national effort
    • Ashley, E.A., The precision medicine initiative: a new national effort. JAMA 313 (2015), 2119–2120.
    • (2015) JAMA , vol.313 , pp. 2119-2120
    • Ashley, E.A.1
  • 25
    • 84923762812 scopus 로고    scopus 로고
    • A new initiative on precision medicine
    • Collins, F.S., Varmus, H., A new initiative on precision medicine. N Engl J Med 372 (2015), 793–795.
    • (2015) N Engl J Med , vol.372 , pp. 793-795
    • Collins, F.S.1    Varmus, H.2
  • 26
    • 84993973265 scopus 로고    scopus 로고
    • Clues toward precision medicine in oral squamous cell carcinoma: utility of next-generation sequencing for the prognostic stratification of high- risk patients harboring neck lymph node extracapsular extension
    • Wang, H.M., Liao, C.T., Yen, T.C., et al. Clues toward precision medicine in oral squamous cell carcinoma: utility of next-generation sequencing for the prognostic stratification of high- risk patients harboring neck lymph node extracapsular extension. Oncotarget 7 (2016), 63082–63092.
    • (2016) Oncotarget , vol.7 , pp. 63082-63092
    • Wang, H.M.1    Liao, C.T.2    Yen, T.C.3
  • 27
    • 84994087188 scopus 로고    scopus 로고
    • Lung cancer: current therapies and new targeted treatments
    • Hirsch, F.R., Scagliotti, G.V., Mulshine, J.L., et al. Lung cancer: current therapies and new targeted treatments. Lancet 389 (2017), 299–311.
    • (2017) Lancet , vol.389 , pp. 299-311
    • Hirsch, F.R.1    Scagliotti, G.V.2    Mulshine, J.L.3
  • 28
    • 85010433794 scopus 로고    scopus 로고
    • Precision medicine in NSCLC and pathology: how does ALK fit in the pathway?
    • Kerr, K.M., Lopez-Rios, F., Precision medicine in NSCLC and pathology: how does ALK fit in the pathway?. Ann Oncol 27:Suppl 3 (2016), iii16–iii24.
    • (2016) Ann Oncol , vol.27 , pp. iii16-iii24
    • Kerr, K.M.1    Lopez-Rios, F.2
  • 29
    • 84984940595 scopus 로고    scopus 로고
    • Ockham's razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer
    • Stella, G.M., Gentile, A., Baderacchi, A., Meloni, F., Milan, M., Benvenuti, S., Ockham's razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer. J Transl Med, 14, 2016, 256.
    • (2016) J Transl Med , vol.14 , pp. 256
    • Stella, G.M.1    Gentile, A.2    Baderacchi, A.3    Meloni, F.4    Milan, M.5    Benvenuti, S.6
  • 30
    • 84962381476 scopus 로고    scopus 로고
    • Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach
    • Ruderfer, D.M., Charney, A.W., Readhead, B., et al. Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach. Lancet Psychiatry 3 (2016), 350–357.
    • (2016) Lancet Psychiatry , vol.3 , pp. 350-357
    • Ruderfer, D.M.1    Charney, A.W.2    Readhead, B.3
  • 31
    • 77951589703 scopus 로고    scopus 로고
    • Clinical assessment incorporating a personal genome
    • Ashley, E.A., Butte, A.J., Wheeler, M.T., et al. Clinical assessment incorporating a personal genome. Lancet 375 (2010), 1525–1535.
    • (2010) Lancet , vol.375 , pp. 1525-1535
    • Ashley, E.A.1    Butte, A.J.2    Wheeler, M.T.3
  • 32
    • 84959230547 scopus 로고    scopus 로고
    • Incorporating a genetic risk score into coronary heart disease risk estimates: effect on low-density lipoprotein cholesterol levels (the MI-GENES Clinical Trial)
    • Kullo, I.J., Jouni, H., Austin, E.E., et al. Incorporating a genetic risk score into coronary heart disease risk estimates: effect on low-density lipoprotein cholesterol levels (the MI-GENES Clinical Trial). Circulation 133 (2016), 1181–1188.
    • (2016) Circulation , vol.133 , pp. 1181-1188
    • Kullo, I.J.1    Jouni, H.2    Austin, E.E.3
  • 33
    • 84920525015 scopus 로고    scopus 로고
    • Whole exome sequencing implicates an INO80D mutation in a syndrome of aortic hypoplasia, premature atherosclerosis, and arterial stiffness
    • Shameer, K., Klee, E.W., Dalenberg, A.K., Kullo, I.J., Whole exome sequencing implicates an INO80D mutation in a syndrome of aortic hypoplasia, premature atherosclerosis, and arterial stiffness. Circ Cardiovasc Genet 7 (2014), 607–614.
    • (2014) Circ Cardiovasc Genet , vol.7 , pp. 607-614
    • Shameer, K.1    Klee, E.W.2    Dalenberg, A.K.3    Kullo, I.J.4
  • 35
    • 0037038224 scopus 로고    scopus 로고
    • Genomic medicine—a primer
    • Guttmacher, A.E., Collins, F.S., Genomic medicine—a primer. N Engl J Med 347 (2002), 1512–1520.
    • (2002) N Engl J Med , vol.347 , pp. 1512-1520
    • Guttmacher, A.E.1    Collins, F.S.2
  • 36
    • 84968813824 scopus 로고    scopus 로고
    • Deep patient: an unsupervised representation to predict the future of patients from the electronic health records
    • Miotto, R., Li, L., Kidd, B.A., Dudley, J.T., Deep patient: an unsupervised representation to predict the future of patients from the electronic health records. Sci Rep, 6, 2016 May 17, 26094, 10.1038/srep26094.
    • (2016) Sci Rep , vol.6 , pp. 26094
    • Miotto, R.1    Li, L.2    Kidd, B.A.3    Dudley, J.T.4
  • 38
    • 85019316083 scopus 로고    scopus 로고
    • Moving beyond regression techniques in cardiovascular risk prediction: applying machine learning to address analytic challenges
    • [E-pub ahead of print]
    • Goldstein, B.A., Navar, A.M., Carter, R.E., Moving beyond regression techniques in cardiovascular risk prediction: applying machine learning to address analytic challenges. Eur Heart J, 2016 Jul 19 [E-pub ahead of print].
    • (2016) Eur Heart J
    • Goldstein, B.A.1    Navar, A.M.2    Carter, R.E.3
  • 39
    • 84862200972 scopus 로고    scopus 로고
    • Escaping the EHR trap—the future of health IT
    • Mandl, K.D., Kohane, I.S., Escaping the EHR trap—the future of health IT. N Engl J Med 366 (2012), 2240–2242.
    • (2012) N Engl J Med , vol.366 , pp. 2240-2242
    • Mandl, K.D.1    Kohane, I.S.2
  • 41
    • 84975795358 scopus 로고    scopus 로고
    • Cognitive machine-learning algorithm for cardiac imaging: a pilot study for differentiating constrictive pericarditis from restrictive cardiomyopathy
    • Sengupta, P.P., Huang, Y.M., Bansal, M., et al. Cognitive machine-learning algorithm for cardiac imaging: a pilot study for differentiating constrictive pericarditis from restrictive cardiomyopathy. Circ Cardiovasc Imaging, 9, 2016, e004330.
    • (2016) Circ Cardiovasc Imaging , vol.9 , pp. e004330
    • Sengupta, P.P.1    Huang, Y.M.2    Bansal, M.3
  • 42
    • 84997693769 scopus 로고    scopus 로고
    • Machine-learning algorithms to automate morphological and functional assessments in 2D echocardiography
    • Narula, S., Shameer, K., Salem Omar, A.M., Dudley, J.T., Sengupta, P.P., Machine-learning algorithms to automate morphological and functional assessments in 2D echocardiography. J Am Coll Cardiol 68 (2016), 2287–2295.
    • (2016) J Am Coll Cardiol , vol.68 , pp. 2287-2295
    • Narula, S.1    Shameer, K.2    Salem Omar, A.M.3    Dudley, J.T.4    Sengupta, P.P.5
  • 43
    • 79960575553 scopus 로고    scopus 로고
    • 3dswap-pred: prediction of 3D domain swapping from protein sequence using Random Forest approach
    • Shameer, K., Pugalenthi, G., Kandaswamy, K.K., Sowdhamini, R., 3dswap-pred: prediction of 3D domain swapping from protein sequence using Random Forest approach. Protein Pept Lett 18 (2011), 1010–1020.
    • (2011) Protein Pept Lett , vol.18 , pp. 1010-1020
    • Shameer, K.1    Pugalenthi, G.2    Kandaswamy, K.K.3    Sowdhamini, R.4
  • 44
    • 77955242486 scopus 로고    scopus 로고
    • Insights into protein sequence and structure-derived features mediating 3D domain swapping mechanism using support vector machine based approach
    • Shameer, K., Pugalenthi, G., Kandaswamy, K.K., Suganthan, P.N., Archunan, G., Sowdhamini, R., Insights into protein sequence and structure-derived features mediating 3D domain swapping mechanism using support vector machine based approach. Bioinform Biol Insights 4 (2010), 33–42.
    • (2010) Bioinform Biol Insights , vol.4 , pp. 33-42
    • Shameer, K.1    Pugalenthi, G.2    Kandaswamy, K.K.3    Suganthan, P.N.4    Archunan, G.5    Sowdhamini, R.6
  • 45
    • 84990892368 scopus 로고    scopus 로고
    • Drug response prediction by inferring pathway-response associations with kernelized Bayesian matrix factorization
    • Ammad-Ud-Din, M., Khan, S.A., Malani, D., et al. Drug response prediction by inferring pathway-response associations with kernelized Bayesian matrix factorization. Bioinformatics 32 (2016), i455–i463.
    • (2016) Bioinformatics , vol.32 , pp. i455-i463
    • Ammad-Ud-Din, M.1    Khan, S.A.2    Malani, D.3
  • 46
    • 84983631327 scopus 로고    scopus 로고
    • Classification of breast cancer patients using somatic mutation profiles and machine learning approaches
    • Vural, S., Wang, X., Guda, C., Classification of breast cancer patients using somatic mutation profiles and machine learning approaches. BMC Syst Biol, 10(Suppl 3), 2016, 62.
    • (2016) BMC Syst Biol , vol.10 , pp. 62
    • Vural, S.1    Wang, X.2    Guda, C.3
  • 47
    • 85034104472 scopus 로고    scopus 로고
    • Multi-parametric non-negative matrix factorization for longitudinal variations detection in white matter fiber-bundles
    • [E-pub ahead of print]
    • Stamile, C., Kocevar, G., Cotton, F., Maes, F., Sappey-Marinier, D., Huffel, S.V., Multi-parametric non-negative matrix factorization for longitudinal variations detection in white matter fiber-bundles. IEEE J Biomed Health Inform, 2016 Aug 3 [E-pub ahead of print].
    • (2016) IEEE J Biomed Health Inform
    • Stamile, C.1    Kocevar, G.2    Cotton, F.3    Maes, F.4    Sappey-Marinier, D.5    Huffel, S.V.6
  • 48
    • 84995421882 scopus 로고    scopus 로고
    • Topological data analysis generates high-resolution, genome-wide maps of human recombination
    • Camara, P.G., Rosenbloom, D.I., Emmett, K.J., Levine, A.J., Rabadan, R., Topological data analysis generates high-resolution, genome-wide maps of human recombination. Cell Syst 3 (2016), 83–94.
    • (2016) Cell Syst , vol.3 , pp. 83-94
    • Camara, P.G.1    Rosenbloom, D.I.2    Emmett, K.J.3    Levine, A.J.4    Rabadan, R.5
  • 49
    • 84978194066 scopus 로고    scopus 로고
    • A multimodal data analysis approach for targeted drug discovery involving topological data analysis (TDA)
    • Alagappan, M., Jiang, D., Denko, N., Koong, A.C., A multimodal data analysis approach for targeted drug discovery involving topological data analysis (TDA). Adv Exp Med Biol 899 (2016), 253–268.
    • (2016) Adv Exp Med Biol , vol.899 , pp. 253-268
    • Alagappan, M.1    Jiang, D.2    Denko, N.3    Koong, A.C.4
  • 50
    • 84945197673 scopus 로고    scopus 로고
    • Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury
    • Nielson, J.L., Paquette, J., Liu, A.W., et al. Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury. Nat Commun, 6, 2015, 8581.
    • (2015) Nat Commun , vol.6 , pp. 8581
    • Nielson, J.L.1    Paquette, J.2    Liu, A.W.3
  • 51
    • 84961972497 scopus 로고    scopus 로고
    • Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data
    • Hinks, T., Zhou, X., Staples, K., et al. Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data. Lancet, 385(Suppl 1), 2015, S42.
    • (2015) Lancet , vol.385 , pp. S42
    • Hinks, T.1    Zhou, X.2    Staples, K.3
  • 52
    • 84971231452 scopus 로고    scopus 로고
    • Unsupervised feature construction and knowledge extraction from genome-wide assays of breast cancer with denoising autoencoders
    • Tan, J., Ung, M., Cheng, C., Greene, C.S., Unsupervised feature construction and knowledge extraction from genome-wide assays of breast cancer with denoising autoencoders. Pac Symp Biocomput 20 (2015), 132–143.
    • (2015) Pac Symp Biocomput , vol.20 , pp. 132-143
    • Tan, J.1    Ung, M.2    Cheng, C.3    Greene, C.S.4
  • 53
    • 84990888204 scopus 로고    scopus 로고
    • DeepChrome: deep-learning for predicting gene expression from histone modifications
    • Singh, R., Lanchantin, J., Robins, G., Qi, Y., DeepChrome: deep-learning for predicting gene expression from histone modifications. Bioinformatics 32 (2016), i639–i648.
    • (2016) Bioinformatics , vol.32 , pp. i639-i648
    • Singh, R.1    Lanchantin, J.2    Robins, G.3    Qi, Y.4
  • 54
    • 85000428361 scopus 로고    scopus 로고
    • Digital mammographic tumor classification using transfer learning from deep convolutional neural networks
    • Huynh, B.Q., Li, H., Giger, M.L., Digital mammographic tumor classification using transfer learning from deep convolutional neural networks. J Med Imaging (Bellingham), 3, 2016, 034501.
    • (2016) J Med Imaging (Bellingham) , vol.3 , pp. 034501
    • Huynh, B.Q.1    Li, H.2    Giger, M.L.3
  • 55
    • 85009238256 scopus 로고    scopus 로고
    • Deep learning for digital pathology image analysis: A comprehensive tutorial with selected use cases
    • Janowczyk, A., Madabhushi, A., Deep learning for digital pathology image analysis: A comprehensive tutorial with selected use cases. J Pathol Inform, 7, 2016, 29.
    • (2016) J Pathol Inform , vol.7 , pp. 29
    • Janowczyk, A.1    Madabhushi, A.2
  • 56
    • 84981288331 scopus 로고    scopus 로고
    • DL-ADR: a novel deep learning model for classifying genomic variants into adverse drug reactions
    • Liang, Z., Huang, J.X., Zeng, X., Zhang, G., DL-ADR: a novel deep learning model for classifying genomic variants into adverse drug reactions. BMC Med Genomics, 9(Suppl 2), 2016, 48.
    • (2016) BMC Med Genomics , vol.9 , pp. 48
    • Liang, Z.1    Huang, J.X.2    Zeng, X.3    Zhang, G.4
  • 57
    • 85016146323 scopus 로고    scopus 로고
    • Using recurrent neural network models for early detection of heart failure onset
    • Choi, E., Schuetz, A., Stewart, W.F., Sun, J., Using recurrent neural network models for early detection of heart failure onset. J Am Med Inform Assoc 24 (2017), 361–370.
    • (2017) J Am Med Inform Assoc , vol.24 , pp. 361-370
    • Choi, E.1    Schuetz, A.2    Stewart, W.F.3    Sun, J.4
  • 58
    • 84986243956 scopus 로고    scopus 로고
    • The Next Era: Deep learning in pharmaceutical research
    • Ekins, S., The Next Era: Deep learning in pharmaceutical research. Pharm Res 33 (2016), 2594–2603.
    • (2016) Pharm Res , vol.33 , pp. 2594-2603
    • Ekins, S.1
  • 59
    • 84954372459 scopus 로고    scopus 로고
    • Deep learning in drug discovery
    • Gawehn, E., Hiss, J.A., Schneider, G., Deep learning in drug discovery. Mol Inform 35 (2016), 3–14.
    • (2016) Mol Inform , vol.35 , pp. 3-14
    • Gawehn, E.1    Hiss, J.A.2    Schneider, G.3
  • 60
    • 84980348164 scopus 로고    scopus 로고
    • Ensembles of deep learning architectures for the early diagnosis of the Alzheimer's disease
    • Ortiz, A., Munilla, J., Gorriz, J.M., Ramirez, J., Ensembles of deep learning architectures for the early diagnosis of the Alzheimer's disease. Int J Neural Syst, 26, 2016, 1650025.
    • (2016) Int J Neural Syst , vol.26 , pp. 1650025
    • Ortiz, A.1    Munilla, J.2    Gorriz, J.M.3    Ramirez, J.4
  • 61
    • 84978204565 scopus 로고    scopus 로고
    • Combining deep learning and level set for the automated segmentation of the left ventricle of the heart from cardiac cine magnetic resonance
    • Ngo, T.A., Lu, Z., Carneiro, G., Combining deep learning and level set for the automated segmentation of the left ventricle of the heart from cardiac cine magnetic resonance. Med Image Anal 35 (2016), 159–171.
    • (2016) Med Image Anal , vol.35 , pp. 159-171
    • Ngo, T.A.1    Lu, Z.2    Carneiro, G.3
  • 62
    • 84979019529 scopus 로고    scopus 로고
    • Deep learning applications for predicting pharmacological properties of drugs and drug repurposing using transcriptomic data
    • Aliper, A., Plis, S., Artemov, A., Ulloa, A., Mamoshina, P., Zhavoronkov, A., Deep learning applications for predicting pharmacological properties of drugs and drug repurposing using transcriptomic data. Mol Pharm 13 (2016), 2524–2530.
    • (2016) Mol Pharm , vol.13 , pp. 2524-2530
    • Aliper, A.1    Plis, S.2    Artemov, A.3    Ulloa, A.4    Mamoshina, P.5    Zhavoronkov, A.6
  • 63
    • 84946040296 scopus 로고    scopus 로고
    • Identification of type 2 diabetes subgroups through topological analysis of patient similarity
    • Li, L., Cheng, W.Y., Glicksberg, B.S., et al. Identification of type 2 diabetes subgroups through topological analysis of patient similarity. Sci Transl Med, 7, 2015, 311ra174.
    • (2015) Sci Transl Med , vol.7 , pp. 311ra174
    • Li, L.1    Cheng, W.Y.2    Glicksberg, B.S.3
  • 65
    • 84880059657 scopus 로고    scopus 로고
    • The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future
    • Gottesman, O., Kuivaniemi, H., Tromp, G., et al. The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet Med 15 (2013), 761–771.
    • (2013) Genet Med , vol.15 , pp. 761-771
    • Gottesman, O.1    Kuivaniemi, H.2    Tromp, G.3
  • 66
    • 85034107726 scopus 로고    scopus 로고
    • Electronic Medical Records and Genomics (eMERGE) Network. Available at: Accessed April 23.
    • National Human Genome Research Institute. Electronic Medical Records and Genomics (eMERGE) Network. Available at: https://www.genome.gov/27540473/electronic-medical-records-and-genomics-emerge-network/. Accessed April 23, 2017.
    • (2017)
    • National Human Genome Research Institute1
  • 67
    • 85034035094 scopus 로고    scopus 로고
    • PheKB. What is the Phenotype KnowledgeBase? Available at: Accessed April 23
    • PheKB. What is the Phenotype KnowledgeBase? Available at: https://phekb.org. Accessed April 23, 2017.
    • (2017)
  • 68
    • 84994697920 scopus 로고    scopus 로고
    • PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability
    • Kirby, J.C., Speltz, P., Rasmussen, L.V., et al. PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability. J Am Med Inform Assoc 23 (2016), 1046–1052.
    • (2016) J Am Med Inform Assoc , vol.23 , pp. 1046-1052
    • Kirby, J.C.1    Speltz, P.2    Rasmussen, L.V.3
  • 69
    • 84995743962 scopus 로고    scopus 로고
    • The digital revolution in phenotyping
    • Oellrich, A., Collier, N., Groza, T., et al. The digital revolution in phenotyping. Brief Bioinform 17 (2016), 819–830.
    • (2016) Brief Bioinform , vol.17 , pp. 819-830
    • Oellrich, A.1    Collier, N.2    Groza, T.3
  • 70
    • 84907284564 scopus 로고    scopus 로고
    • Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome
    • Zemojtel, T., Kohler, S., Mackenroth, L., et al. Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome. Sci Transl Med, 6, 2014, 252ra123.
    • (2014) Sci Transl Med , vol.6 , pp. 252ra123
    • Zemojtel, T.1    Kohler, S.2    Mackenroth, L.3
  • 71
    • 84992053162 scopus 로고    scopus 로고
    • Predictive computational phenotyping and biomarker discovery using reference-free genome comparisons
    • Drouin, A., Giguere, S., Deraspe, M., et al. Predictive computational phenotyping and biomarker discovery using reference-free genome comparisons. BMC Genomics, 17, 2016, 754.
    • (2016) BMC Genomics , vol.17 , pp. 754
    • Drouin, A.1    Giguere, S.2    Deraspe, M.3
  • 72
    • 84921845885 scopus 로고    scopus 로고
    • Cost-effectiveness of hypertension therapy according to 2014 guidelines
    • Cost-effectiveness of hypertension therapy according to 2014 guidelines. N Engl J Med, 372, 2015, 1677.
    • (2015) N Engl J Med , vol.372 , pp. 1677
  • 73
  • 74
    • 84962541153 scopus 로고    scopus 로고
    • Pharmacogenetics of lipid-lowering agents: precision or indecision medicine?
    • Alfonsi, J.E., Hegele, R.A., Gryn, S.E., Pharmacogenetics of lipid-lowering agents: precision or indecision medicine?. Curr Atheroscler Rep, 18, 2016, 24.
    • (2016) Curr Atheroscler Rep , vol.18 , pp. 24
    • Alfonsi, J.E.1    Hegele, R.A.2    Gryn, S.E.3
  • 75
    • 84861230309 scopus 로고    scopus 로고
    • Pleiotropic effects of statins: the role of eicosanoid production
    • Birnbaum, Y., Ye, Y., Pleiotropic effects of statins: the role of eicosanoid production. Curr Atheroscler Rep 14 (2012), 135–139.
    • (2012) Curr Atheroscler Rep , vol.14 , pp. 135-139
    • Birnbaum, Y.1    Ye, Y.2
  • 76
    • 84870050309 scopus 로고    scopus 로고
    • Translating the effects of statins: from redox regulation to suppression of vascular wall inflammation
    • Antonopoulos, A.S., Margaritis, M., Shirodaria, C., Antoniades, C., Translating the effects of statins: from redox regulation to suppression of vascular wall inflammation. Thromb Haemost 108 (2012), 840–848.
    • (2012) Thromb Haemost , vol.108 , pp. 840-848
    • Antonopoulos, A.S.1    Margaritis, M.2    Shirodaria, C.3    Antoniades, C.4
  • 77
    • 77958541531 scopus 로고    scopus 로고
    • The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in cardiovascular disease: a comprehensive review
    • Mihos, C.G., Salas, M.J., Santana, O., The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in cardiovascular disease: a comprehensive review. Cardiol Rev 18 (2010), 298–304.
    • (2010) Cardiol Rev , vol.18 , pp. 298-304
    • Mihos, C.G.1    Salas, M.J.2    Santana, O.3
  • 78
    • 84886925684 scopus 로고    scopus 로고
    • Predicting the risk of cardiovascular comorbidities in adult cancer survivors
    • Tashakkor, A.Y., Moghaddamjou, A., Chen, L., Cheung, W.Y., Predicting the risk of cardiovascular comorbidities in adult cancer survivors. Curr Oncol 20 (2013), e360–e370.
    • (2013) Curr Oncol , vol.20 , pp. e360-e370
    • Tashakkor, A.Y.1    Moghaddamjou, A.2    Chen, L.3    Cheung, W.Y.4
  • 79
    • 84954502979 scopus 로고    scopus 로고
    • Cardiovascular comorbidities relate more than others with disease activity in rheumatoid arthritis
    • Crepaldi, G., Scire, C.A., Carrara, G., et al. Cardiovascular comorbidities relate more than others with disease activity in rheumatoid arthritis. PLoS One, 11, 2016, e0146991.
    • (2016) PLoS One , vol.11 , pp. e0146991
    • Crepaldi, G.1    Scire, C.A.2    Carrara, G.3
  • 81
    • 84987670072 scopus 로고    scopus 로고
    • Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
    • Surendran, P., Drenos, F., Young, R., et al. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet 48 (2016), 1151–1161.
    • (2016) Nat Genet , vol.48 , pp. 1151-1161
    • Surendran, P.1    Drenos, F.2    Young, R.3
  • 82
    • 84925663443 scopus 로고    scopus 로고
    • Antihypertensive medication classes used among medicare beneficiaries initiating treatment in 2007–2010
    • Kent, S.T., Shimbo, D., Huang, L., et al. Antihypertensive medication classes used among medicare beneficiaries initiating treatment in 2007–2010. PLoS One, 9, 2014, e105888.
    • (2014) PLoS One , vol.9 , pp. e105888
    • Kent, S.T.1    Shimbo, D.2    Huang, L.3
  • 83
    • 84908166637 scopus 로고    scopus 로고
    • The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT)
    • Ambrosius, W.T., Sink, K.M., Foy, C.G., et al. The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT). Clin Trials 11 (2014), 532–546.
    • (2014) Clin Trials , vol.11 , pp. 532-546
    • Ambrosius, W.T.1    Sink, K.M.2    Foy, C.G.3
  • 84
    • 84893549987 scopus 로고    scopus 로고
    • 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)
    • James, P.A., Oparil, S., Carter, B.L., et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 311 (2014), 507–520.
    • (2014) JAMA , vol.311 , pp. 507-520
    • James, P.A.1    Oparil, S.2    Carter, B.L.3
  • 85
    • 84908153218 scopus 로고    scopus 로고
    • The heterogeneity of heart failure: will enhanced phenotyping be necessary for future clinical trial success?
    • Francis, G.S., Cogswell, R., Thenappan, T., The heterogeneity of heart failure: will enhanced phenotyping be necessary for future clinical trial success?. J Am Coll Cardiol 64 (2014), 1775–1776.
    • (2014) J Am Coll Cardiol , vol.64 , pp. 1775-1776
    • Francis, G.S.1    Cogswell, R.2    Thenappan, T.3
  • 86
    • 84925353270 scopus 로고    scopus 로고
    • Systems biology and clinical phenotypes of heart failure syndrome
    • Louridas, G.E., Lourida, K.G., Systems biology and clinical phenotypes of heart failure syndrome. J Am Coll Cardiol 65 (2015), 1269–1270.
    • (2015) J Am Coll Cardiol , vol.65 , pp. 1269-1270
    • Louridas, G.E.1    Lourida, K.G.2
  • 87
    • 84978842076 scopus 로고    scopus 로고
    • Heart failure update: diagnosis and classification
    • Eckstein, D., Korabathina, R., Heart failure update: diagnosis and classification. FP Essent 442 (2016), 11–17.
    • (2016) FP Essent , vol.442 , pp. 11-17
    • Eckstein, D.1    Korabathina, R.2
  • 89
    • 84969166491 scopus 로고    scopus 로고
    • Developing new treatments for heart failure: focus on the heart
    • Gheorghiade, M., Larson, C.J., Shah, S.J., et al. Developing new treatments for heart failure: focus on the heart. Circ Heart Fail, 9, 2016.
    • (2016) Circ Heart Fail , vol.9
    • Gheorghiade, M.1    Larson, C.J.2    Shah, S.J.3
  • 90
    • 84908177699 scopus 로고    scopus 로고
    • Clinical implications of chronic heart failure phenotypes defined by cluster analysis
    • Ahmad, T., Pencina, M.J., Schulte, P.J., et al. Clinical implications of chronic heart failure phenotypes defined by cluster analysis. J Am Coll Cardiol 64 (2014), 1765–1774.
    • (2014) J Am Coll Cardiol , vol.64 , pp. 1765-1774
    • Ahmad, T.1    Pencina, M.J.2    Schulte, P.J.3
  • 91
    • 84925355631 scopus 로고    scopus 로고
    • Applying cluster analysis to data of previously published chronic heart failure trials
    • Madias, J.E., Applying cluster analysis to data of previously published chronic heart failure trials. J Am Coll Cardiol 65 (2015), 1268–1269.
    • (2015) J Am Coll Cardiol , vol.65 , pp. 1268-1269
    • Madias, J.E.1
  • 92
    • 84925357066 scopus 로고    scopus 로고
    • Reply: applying cluster analysis to data of previously published chronic heart failure trials: systems biology and clinical phenotypes of heart failure syndrome
    • Ahmad, T., Felker, G.M., Reply: applying cluster analysis to data of previously published chronic heart failure trials: systems biology and clinical phenotypes of heart failure syndrome. J Am Coll Cardiol 65 (2015), 1270–1271.
    • (2015) J Am Coll Cardiol , vol.65 , pp. 1270-1271
    • Ahmad, T.1    Felker, G.M.2
  • 94
    • 84959268154 scopus 로고    scopus 로고
    • Cross-tissue regulatory gene networks in coronary artery disease
    • Talukdar, H.A., Foroughi Asl, H., Jain, R.K., et al. Cross-tissue regulatory gene networks in coronary artery disease. Cell Syst 2 (2016), 196–208.
    • (2016) Cell Syst , vol.2 , pp. 196-208
    • Talukdar, H.A.1    Foroughi Asl, H.2    Jain, R.K.3
  • 95
    • 84983472699 scopus 로고    scopus 로고
    • Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases
    • Franzen, O., Ermel, R., Cohain, A., et al. Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases. Science 353 (2016), 827–830.
    • (2016) Science , vol.353 , pp. 827-830
    • Franzen, O.1    Ermel, R.2    Cohain, A.3
  • 96
    • 84929377932 scopus 로고    scopus 로고
    • Back to the future: improving the use of guidelines-recommended coronary disease secondary prevention at the dawn of the precision medicine era
    • Rymer, J.A., Newby, L.K., Back to the future: improving the use of guidelines-recommended coronary disease secondary prevention at the dawn of the precision medicine era. Circulation 131 (2015), 1234–1235.
    • (2015) Circulation , vol.131 , pp. 1234-1235
    • Rymer, J.A.1    Newby, L.K.2
  • 97
    • 84941056057 scopus 로고    scopus 로고
    • The emergence of cardiovascular imaging as a subspecialty and individualized treatment of coronary artery disease: two related trends
    • Shurlock, B., The emergence of cardiovascular imaging as a subspecialty and individualized treatment of coronary artery disease: two related trends. Eur Heart J 35 (2014), 3392–3393.
    • (2014) Eur Heart J , vol.35 , pp. 3392-3393
    • Shurlock, B.1
  • 98
    • 84924143281 scopus 로고    scopus 로고
    • Biomarkers of coronary artery disease differ between Asians and Caucasians in the general population
    • Gijsberts, C.M., den Ruijter, H.M., Asselbergs, F.W., Chan, M.Y., de Kleijn, D.P., Hoefer, I.E., Biomarkers of coronary artery disease differ between Asians and Caucasians in the general population. Glob Heart 10 (2015), 301–311.e11.
    • (2015) Glob Heart , vol.10 , pp. 301-311.e11
    • Gijsberts, C.M.1    den Ruijter, H.M.2    Asselbergs, F.W.3    Chan, M.Y.4    de Kleijn, D.P.5    Hoefer, I.E.6
  • 99
    • 84904282289 scopus 로고    scopus 로고
    • Evolving biomarkers improve prediction of long-term mortality in patients with stable coronary artery disease: the BIO-VILCAD score
    • Kleber, M.E., Goliasch, G., Grammer, T.B., et al. Evolving biomarkers improve prediction of long-term mortality in patients with stable coronary artery disease: the BIO-VILCAD score. J Intern Med 276 (2014), 184–194.
    • (2014) J Intern Med , vol.276 , pp. 184-194
    • Kleber, M.E.1    Goliasch, G.2    Grammer, T.B.3
  • 100
    • 84984905354 scopus 로고    scopus 로고
    • The role of serum levels of microRNA-21 and matrix metalloproteinase-9 in patients with acute coronary syndrome
    • Darabi, F., Aghaei, M., Movahedian, A., Pourmoghadas, A., Sarrafzadegan, N., The role of serum levels of microRNA-21 and matrix metalloproteinase-9 in patients with acute coronary syndrome. Mol Cell Biochem 422 (2016), 51–60.
    • (2016) Mol Cell Biochem , vol.422 , pp. 51-60
    • Darabi, F.1    Aghaei, M.2    Movahedian, A.3    Pourmoghadas, A.4    Sarrafzadegan, N.5
  • 101
    • 84984869267 scopus 로고    scopus 로고
    • Association of soluble fibrinogen-like protein 2 with the severity of coronary artery disease
    • Cheng, J., Chen, Y., Xu, B., Wu, J., He, F., Association of soluble fibrinogen-like protein 2 with the severity of coronary artery disease. Intern Med 55 (2016), 2343–2350.
    • (2016) Intern Med , vol.55 , pp. 2343-2350
    • Cheng, J.1    Chen, Y.2    Xu, B.3    Wu, J.4    He, F.5
  • 102
    • 84988383522 scopus 로고    scopus 로고
    • Serum levels of mitochondrial inhibitory factor 1 are independently associated with long-term prognosis in coronary artery disease: the GENES Study
    • Genoux, A., Lichtenstein, L., Ferrieres, J., et al. Serum levels of mitochondrial inhibitory factor 1 are independently associated with long-term prognosis in coronary artery disease: the GENES Study. BMC Med, 14, 2016, 125.
    • (2016) BMC Med , vol.14 , pp. 125
    • Genoux, A.1    Lichtenstein, L.2    Ferrieres, J.3
  • 103
    • 85000716796 scopus 로고    scopus 로고
    • The impact of biochemical markers on major adverse cardiovascular events and contralateral carotid artery stenosis progression following carotid interventions
    • Stone, P.A., Thompson, S.N., Khan, M., Northfield, E., Schillinger, R., Skaff, P., The impact of biochemical markers on major adverse cardiovascular events and contralateral carotid artery stenosis progression following carotid interventions. Ann Vasc Surg 38 (2017), 144–150.
    • (2017) Ann Vasc Surg , vol.38 , pp. 144-150
    • Stone, P.A.1    Thompson, S.N.2    Khan, M.3    Northfield, E.4    Schillinger, R.5    Skaff, P.6
  • 104
    • 84981501479 scopus 로고    scopus 로고
    • Plasma microRNA-126-5p is associated with the complexity and severity of coronary artery disease in patients with stable angina pectoris
    • Li, H.Y., Zhao, X., Liu, Y.Z., et al. Plasma microRNA-126-5p is associated with the complexity and severity of coronary artery disease in patients with stable angina pectoris. Cell Physiol Biochem 39 (2016), 837–846.
    • (2016) Cell Physiol Biochem , vol.39 , pp. 837-846
    • Li, H.Y.1    Zhao, X.2    Liu, Y.Z.3
  • 105
    • 0742305866 scopus 로고    scopus 로고
    • Network biology: understanding the cell's functional organization
    • Barabasi, A.L., Oltvai, Z.N., Network biology: understanding the cell's functional organization. Nat Rev Genet 5 (2004), 101–113.
    • (2004) Nat Rev Genet , vol.5 , pp. 101-113
    • Barabasi, A.L.1    Oltvai, Z.N.2
  • 106
    • 84902649945 scopus 로고    scopus 로고
    • Understanding protein-nanoparticle interaction: a new gateway to disease therapeutics
    • Giri, K., Shameer, K., Zimmermann, M.T., et al. Understanding protein-nanoparticle interaction: a new gateway to disease therapeutics. Bioconjug Chem 25 (2014), 1078–1090.
    • (2014) Bioconjug Chem , vol.25 , pp. 1078-1090
    • Giri, K.1    Shameer, K.2    Zimmermann, M.T.3
  • 107
    • 84872461605 scopus 로고    scopus 로고
    • Social network analysis: foundations and frontiers on advantage
    • Burt, R.S., Kilduff, M., Tasselli, S., Social network analysis: foundations and frontiers on advantage. Annu Rev Psychol 64 (2013), 527–547.
    • (2013) Annu Rev Psychol , vol.64 , pp. 527-547
    • Burt, R.S.1    Kilduff, M.2    Tasselli, S.3
  • 108
    • 79952674000 scopus 로고    scopus 로고
    • Interactome networks and human disease
    • Vidal, M., Cusick, M.E., Barabasi, A.L., Interactome networks and human disease. Cell 144 (2011), 986–998.
    • (2011) Cell , vol.144 , pp. 986-998
    • Vidal, M.1    Cusick, M.E.2    Barabasi, A.L.3
  • 109
    • 84971212642 scopus 로고    scopus 로고
    • An integrative pipeline for multi-modal discovery of disease relationships
    • Glicksberg, B.S., Li, L., Cheng, W.Y., et al. An integrative pipeline for multi-modal discovery of disease relationships. Pac Symp Biocomput, 2015, 407–418.
    • (2015) Pac Symp Biocomput , pp. 407-418
    • Glicksberg, B.S.1    Li, L.2    Cheng, W.Y.3
  • 110
    • 84976480079 scopus 로고    scopus 로고
    • Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks
    • Glicksberg, B.S., Li, L., Badgeley, M.A., et al. Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks. Bioinformatics 32 (2016), i101–i110.
    • (2016) Bioinformatics , vol.32 , pp. i101-i110
    • Glicksberg, B.S.1    Li, L.2    Badgeley, M.A.3
  • 111
    • 84876888105 scopus 로고    scopus 로고
    • Challenges and opportunities of drug repositioning
    • Novac, N., Challenges and opportunities of drug repositioning. Trends Pharmacol Sci 34 (2013), 267–272.
    • (2013) Trends Pharmacol Sci , vol.34 , pp. 267-272
    • Novac, N.1
  • 112
    • 84867338003 scopus 로고    scopus 로고
    • Discovery and preclinical validation of drug indications using compendia of public gene expression data
    • Sirota, M., Dudley, J.T., Kim, J., et al. Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Transl Med, 3, 2011, 96ra77.
    • (2011) Sci Transl Med , vol.3 , pp. 96ra77
    • Sirota, M.1    Dudley, J.T.2    Kim, J.3
  • 113
    • 84922285922 scopus 로고    scopus 로고
    • Computational and experimental advances in drug repositioning for accelerated therapeutic stratification
    • Shameer, K., Readhead, B., Dudley, J.T., Computational and experimental advances in drug repositioning for accelerated therapeutic stratification. Curr Top Med Chem 15 (2015), 5–20.
    • (2015) Curr Top Med Chem , vol.15 , pp. 5-20
    • Shameer, K.1    Readhead, B.2    Dudley, J.T.3
  • 114
    • 85034053171 scopus 로고    scopus 로고
    • RepurposeDB. Repositioning investigations. Available at: Accessed April 23
    • RepurposeDB. Repositioning investigations. Available at: http://repurposedb.dudleylab.org/. Accessed April 23, 2017.
    • (2017)
  • 115
    • 0029937949 scopus 로고    scopus 로고
    • The effect of carvedilol on morbidity and mortality in patients with chronic heart failure
    • Packer, M., Bristow, M.R., Cohn, J.N., et al., for the U.S. Carvedilol Heart Failure Study Group. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med 334 (1996), 1349–1355.
    • (1996) N Engl J Med , vol.334 , pp. 1349-1355
    • Packer, M.1    Bristow, M.R.2    Cohn, J.N.3
  • 116
    • 0018759507 scopus 로고
    • Prolongation of survival in congestive cardiomyopathy by beta-receptor blockade
    • Swedberg, K., Hjalmarson, A., Waagstein, F., Wallentin, I., Prolongation of survival in congestive cardiomyopathy by beta-receptor blockade. Lancet 1 (1979), 1374–1376.
    • (1979) Lancet , vol.1 , pp. 1374-1376
    • Swedberg, K.1    Hjalmarson, A.2    Waagstein, F.3    Wallentin, I.4
  • 117
    • 0013932912 scopus 로고
    • The effect of beta adrenergic blockade on patterns of urinary sodium excretion. Studies in normal subjects and in patients with heart disease
    • Epstein, S.E., Braunwald, E., The effect of beta adrenergic blockade on patterns of urinary sodium excretion. Studies in normal subjects and in patients with heart disease. Ann Intern Med 65 (1966), 20–27.
    • (1966) Ann Intern Med , vol.65 , pp. 20-27
    • Epstein, S.E.1    Braunwald, E.2
  • 118
    • 0031951754 scopus 로고    scopus 로고
    • Cyclic-GMP-binding, cyclic-GMP-specific phosphodiesterase (PDE5) gene expression is regulated during rat pulmonary development
    • Sanchez, L.S., de la Monte, S.M., Filippov, G., Jones, R.C., Zapol, W.M., Bloch, K.D., Cyclic-GMP-binding, cyclic-GMP-specific phosphodiesterase (PDE5) gene expression is regulated during rat pulmonary development. Pediatr Res 43 (1998), 163–168.
    • (1998) Pediatr Res , vol.43 , pp. 163-168
    • Sanchez, L.S.1    de la Monte, S.M.2    Filippov, G.3    Jones, R.C.4    Zapol, W.M.5    Bloch, K.D.6
  • 119
    • 33846911349 scopus 로고    scopus 로고
    • Sildenafil in the treatment of pulmonary hypertension
    • Barnett, C.F., Machado, R.F., Sildenafil in the treatment of pulmonary hypertension. Vasc Health Risk Manag 2 (2006), 411–422.
    • (2006) Vasc Health Risk Manag , vol.2 , pp. 411-422
    • Barnett, C.F.1    Machado, R.F.2
  • 120
    • 33746584053 scopus 로고    scopus 로고
    • Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
    • Ghofrani, H.A., Osterloh, I.H., Grimminger, F., Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat Rev Drug Discov 5 (2006), 689–702.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 689-702
    • Ghofrani, H.A.1    Osterloh, I.H.2    Grimminger, F.3
  • 121
    • 84948382896 scopus 로고    scopus 로고
    • Drug repurposing in oncology—patient and health systems opportunities
    • Bertolini, F., Sukhatme, V.P., Bouche, G., Drug repurposing in oncology—patient and health systems opportunities. Nat Rev Clin Oncol 12 (2015), 732–742.
    • (2015) Nat Rev Clin Oncol , vol.12 , pp. 732-742
    • Bertolini, F.1    Sukhatme, V.P.2    Bouche, G.3
  • 123
    • 84948383442 scopus 로고    scopus 로고
    • Systems biology approaches to adverse drug effects: the example of cardio-oncology
    • Brown, S.A., Sandhu, N., Herrmann, J., Systems biology approaches to adverse drug effects: the example of cardio-oncology. Nat Rev Clin Oncol 12 (2015), 718–731.
    • (2015) Nat Rev Clin Oncol , vol.12 , pp. 718-731
    • Brown, S.A.1    Sandhu, N.2    Herrmann, J.3
  • 124
    • 85034082605 scopus 로고    scopus 로고
    • RepurposeDB. Drugs. Available at: Accessed April 23
    • RepurposeDB. Drugs. Available at: http://repurposedb.dudleylab.org/browseDrugs. Accessed April 23, 2017.
    • (2017)
  • 125
    • 84896691663 scopus 로고    scopus 로고
    • Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer
    • Bharadwaj, U., Eckols, T.K., Kolosov, M., et al. Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Oncogene 34 (2015), 1341–1353.
    • (2015) Oncogene , vol.34 , pp. 1341-1353
    • Bharadwaj, U.1    Eckols, T.K.2    Kolosov, M.3
  • 126
    • 84868379118 scopus 로고    scopus 로고
    • Drug repositioning for Alzheimer's disease
    • Corbett, A., Pickett, J., Burns, A., et al. Drug repositioning for Alzheimer's disease. Nat Rev Drug Discov 11 (2012), 833–846.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 833-846
    • Corbett, A.1    Pickett, J.2    Burns, A.3
  • 128
    • 33645452696 scopus 로고    scopus 로고
    • Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application
    • Millan, M.J., Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther 110 (2006), 135–370.
    • (2006) Pharmacol Ther , vol.110 , pp. 135-370
    • Millan, M.J.1
  • 129
    • 84863085673 scopus 로고    scopus 로고
    • Multi-target drugs: the trend of drug research and development
    • Lu, J.J., Pan, W., Hu, Y.J., Wang, Y.T., Multi-target drugs: the trend of drug research and development. PLoS One, 7, 2012, e40262.
    • (2012) PLoS One , vol.7 , pp. e40262
    • Lu, J.J.1    Pan, W.2    Hu, Y.J.3    Wang, Y.T.4
  • 130
    • 33845762340 scopus 로고    scopus 로고
    • Multi-target therapeutics: when the whole is greater than the sum of the parts
    • Zimmermann, G.R., Lehar, J., Keith, C.T., Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today 12 (2007), 34–42.
    • (2007) Drug Discov Today , vol.12 , pp. 34-42
    • Zimmermann, G.R.1    Lehar, J.2    Keith, C.T.3
  • 133
    • 0035153910 scopus 로고    scopus 로고
    • Quinupristin/dalfopristin: a therapeutic review
    • Allington, D.R., Rivey, M.P., Quinupristin/dalfopristin: a therapeutic review. Clin Ther 23 (2001), 24–44.
    • (2001) Clin Ther , vol.23 , pp. 24-44
    • Allington, D.R.1    Rivey, M.P.2
  • 134
    • 54249155522 scopus 로고    scopus 로고
    • Network pharmacology: the next paradigm in drug discovery
    • Hopkins, A.L., Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 4 (2008), 682–690.
    • (2008) Nat Chem Biol , vol.4 , pp. 682-690
    • Hopkins, A.L.1
  • 135
    • 79952444246 scopus 로고    scopus 로고
    • Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association
    • Heidenreich, P.A., Trogdon, J.G., Khavjou, O.A., et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation 123 (2011), 933–944.
    • (2011) Circulation , vol.123 , pp. 933-944
    • Heidenreich, P.A.1    Trogdon, J.G.2    Khavjou, O.A.3
  • 136
    • 84906233173 scopus 로고    scopus 로고
    • The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study
    • Kullo, I.J., Shameer, K., Jouni, H., et al. The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study. Front Genet, 5, 2014, 166.
    • (2014) Front Genet , vol.5 , pp. 166
    • Kullo, I.J.1    Shameer, K.2    Jouni, H.3
  • 137
    • 4444382796 scopus 로고    scopus 로고
    • Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case- control study
    • Yusuf, S., Hawken, S., Ounpuu, S., et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case- control study. Lancet 364 (2004), 937–952.
    • (2004) Lancet , vol.364 , pp. 937-952
    • Yusuf, S.1    Hawken, S.2    Ounpuu, S.3
  • 138
    • 0037118660 scopus 로고    scopus 로고
    • AHA guidelines for primary prevention of cardiovascular disease and stroke: 2002 update: consensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases. American Heart Association Science Advisory and Coordinating Committee
    • Pearson, T.A., Blair, S.N., Daniels, S.R., et al. AHA guidelines for primary prevention of cardiovascular disease and stroke: 2002 update: consensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases. American Heart Association Science Advisory and Coordinating Committee. Circulation 106 (2002), 388–391.
    • (2002) Circulation , vol.106 , pp. 388-391
    • Pearson, T.A.1    Blair, S.N.2    Daniels, S.R.3
  • 139
    • 85034067075 scopus 로고    scopus 로고
    • cBioPortal for Cancer Genomics. Available at: Accessed April 23
    • cBioPortal for Cancer Genomics. Available at: http://www.cbioportal.org/. Accessed April 23, 2017.
    • (2017)
  • 140
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
    • Cerami, E., Gao, J., Dogrusoz, U., et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2 (2012), 401–404.
    • (2012) Cancer Discov , vol.2 , pp. 401-404
    • Cerami, E.1    Gao, J.2    Dogrusoz, U.3
  • 141
    • 84924312533 scopus 로고    scopus 로고
    • The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data
    • Tang, X., Baheti, S., Shameer, K., et al. The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data. Nucleic Acids Res, 42, 2014, e172.
    • (2014) Nucleic Acids Res , vol.42 , pp. e172
    • Tang, X.1    Baheti, S.2    Shameer, K.3
  • 143
    • 84979041873 scopus 로고    scopus 로고
    • Oncology nurses and the Cancer Moonshot 2020
    • Kennedy Sheldon, L., Oncology nurses and the Cancer Moonshot 2020. Clin J Oncol Nurs 20 (2016), 355–356.
    • (2016) Clin J Oncol Nurs , vol.20 , pp. 355-356
    • Kennedy Sheldon, L.1
  • 144
    • 85034055060 scopus 로고    scopus 로고
    • News. ‘1 Team, 1 Vision’—AHA, Google Life Sciences launch $50 million project. Available at: Accessed April 23
    • American Heart Association News. ‘1 Team, 1 Vision’—AHA, Google Life Sciences launch $50 million project. Available at: http://news.heart.org/american-heart-association-google-life-sciences-seeking-novel-strategies-to-prevent-heart-disease/. Accessed April 23, 2017.
    • (2017)
    • American Heart Association1
  • 145
    • 84939542491 scopus 로고    scopus 로고
    • Cardiovascular precision medicine: hope or hype?
    • Pitt, G.S., Cardiovascular precision medicine: hope or hype?. Eur Heart J 36 (2015), 1842–1843.
    • (2015) Eur Heart J , vol.36 , pp. 1842-1843
    • Pitt, G.S.1
  • 146
    • 84962090118 scopus 로고    scopus 로고
    • Medical student preparedness for an era of personalized medicine: findings from one US medical school
    • Eden, C., Johnson, K.W., Gottesman, O., Bottinger, E.P., Abul-Husn, N.S., Medical student preparedness for an era of personalized medicine: findings from one US medical school. Per Med 13 (2016), 129–141.
    • (2016) Per Med , vol.13 , pp. 129-141
    • Eden, C.1    Johnson, K.W.2    Gottesman, O.3    Bottinger, E.P.4    Abul-Husn, N.S.5
  • 147
    • 0242412914 scopus 로고    scopus 로고
    • Bioinformatics and medical informatics: collaborations on the road to genomic medicine?
    • Maojo, V., Kulikowski, C.A., Bioinformatics and medical informatics: collaborations on the road to genomic medicine?. J Am Med Inform Assoc 10 (2003), 515–522.
    • (2003) J Am Med Inform Assoc , vol.10 , pp. 515-522
    • Maojo, V.1    Kulikowski, C.A.2
  • 148
    • 0032489974 scopus 로고    scopus 로고
    • Healthcare and the information age: implications for medical education
    • Carlile, S., Sefton, A.J., Healthcare and the information age: implications for medical education. Med J Aust 168 (1998), 340–343.
    • (1998) Med J Aust , vol.168 , pp. 340-343
    • Carlile, S.1    Sefton, A.J.2
  • 149
    • 84962218879 scopus 로고    scopus 로고
    • EHDViz: clinical dashboard development using open-source technologies
    • Badgeley, M.A., Shameer, K., Glicksberg, B.S., et al. EHDViz: clinical dashboard development using open-source technologies. BMJ Open, 6, 2016, e010579.
    • (2016) BMJ Open , vol.6 , pp. e010579
    • Badgeley, M.A.1    Shameer, K.2    Glicksberg, B.S.3
  • 150
    • 84912093496 scopus 로고    scopus 로고
    • Visual analytics in healthcare education: exploring novel ways to analyze and represent big data in undergraduate medical education
    • Vaitsis, C., Nilsson, G., Zary, N., Visual analytics in healthcare education: exploring novel ways to analyze and represent big data in undergraduate medical education. PeerJ, 2, 2014, e683.
    • (2014) PeerJ , vol.2 , pp. e683
    • Vaitsis, C.1    Nilsson, G.2    Zary, N.3
  • 151
    • 0031023489 scopus 로고    scopus 로고
    • Shared decision-making in the medical encounter: what does it mean? (or it takes at least two to tango)
    • Charles, C., Gafni, A., Whelan, T., Shared decision-making in the medical encounter: what does it mean? (or it takes at least two to tango). Soc Sci Med 44 (1997), 681–692.
    • (1997) Soc Sci Med , vol.44 , pp. 681-692
    • Charles, C.1    Gafni, A.2    Whelan, T.3
  • 152
    • 84961393205 scopus 로고    scopus 로고
    • Big data analytics to improve cardiovascular care: promise and challenges
    • Rumsfeld, J.S., Joynt, K.E., Maddox, T.M., Big data analytics to improve cardiovascular care: promise and challenges. Nat Rev Cardiol 13 (2016), 350–359.
    • (2016) Nat Rev Cardiol , vol.13 , pp. 350-359
    • Rumsfeld, J.S.1    Joynt, K.E.2    Maddox, T.M.3
  • 153
    • 73349096011 scopus 로고    scopus 로고
    • An electronic clinical decision support tool to assist primary care providers in cardiovascular disease risk management: development and mixed methods evaluation
    • Peiris, D.P., Joshi, R., Webster, R.J., et al. An electronic clinical decision support tool to assist primary care providers in cardiovascular disease risk management: development and mixed methods evaluation. J Med Internet Res, 11, 2009, e51.
    • (2009) J Med Internet Res , vol.11 , pp. e51
    • Peiris, D.P.1    Joshi, R.2    Webster, R.J.3
  • 154
    • 80053986227 scopus 로고    scopus 로고
    • Pharmacogenetics and cost-effectiveness analysis: a two-way street
    • Chalkidou, K., Rawlins, M., Pharmacogenetics and cost-effectiveness analysis: a two-way street. Drug Discov Today 16 (2011), 873–877.
    • (2011) Drug Discov Today , vol.16 , pp. 873-877
    • Chalkidou, K.1    Rawlins, M.2
  • 155
    • 84893797996 scopus 로고    scopus 로고
    • Cost-effectiveness of pharmacogenetics- guided warfarin therapy vs. alternative anticoagulation in atrial fibrillation
    • Pink, J., Pirmohamed, M., Lane, S., Hughes, D.A., Cost-effectiveness of pharmacogenetics- guided warfarin therapy vs. alternative anticoagulation in atrial fibrillation. Clin Pharmacol Ther 95 (2014), 199–207.
    • (2014) Clin Pharmacol Ther , vol.95 , pp. 199-207
    • Pink, J.1    Pirmohamed, M.2    Lane, S.3    Hughes, D.A.4
  • 156
    • 84976262193 scopus 로고    scopus 로고
    • Cost-effectiveness of pharmacogenetic- guided dosing of warfarin in the United Kingdom and Sweden
    • Verhoef, T.I., Redekop, W.K., Langenskiold, S., et al. Cost-effectiveness of pharmacogenetic- guided dosing of warfarin in the United Kingdom and Sweden. Pharmacogenomics J 16 (2016), 478–484.
    • (2016) Pharmacogenomics J , vol.16 , pp. 478-484
    • Verhoef, T.I.1    Redekop, W.K.2    Langenskiold, S.3
  • 157
    • 85034050677 scopus 로고    scopus 로고
    • Cost-effectiveness of a novel pharmacist guided warfarin pharmacogenetic service
    • Gor, D., Kim, K., Chumnumwat, S., et al. Cost-effectiveness of a novel pharmacist guided warfarin pharmacogenetic service. Value Health, 18, 2015, A390.
    • (2015) Value Health , vol.18 , pp. A390
    • Gor, D.1    Kim, K.2    Chumnumwat, S.3
  • 158
    • 84891030619 scopus 로고    scopus 로고
    • Pharmacogenetic-guided selection of warfarin versus novel oral anticoagulants for stroke prevention in patients with atrial fibrillation: a cost-effectiveness analysis
    • You, J.H., Pharmacogenetic-guided selection of warfarin versus novel oral anticoagulants for stroke prevention in patients with atrial fibrillation: a cost-effectiveness analysis. Pharmacogenet Genomics 24 (2014), 6–14.
    • (2014) Pharmacogenet Genomics , vol.24 , pp. 6-14
    • You, J.H.1
  • 159
    • 84976871516 scopus 로고    scopus 로고
    • GWASdb v2: an update database for human genetic variants identified by genome-wide association studies
    • Li, M.J., Liu, Z., Wang, P., et al. GWASdb v2: an update database for human genetic variants identified by genome-wide association studies. Nucleic Acids Res 44 (2016), D869–D876.
    • (2016) Nucleic Acids Res , vol.44 , pp. D869-D876
    • Li, M.J.1    Liu, Z.2    Wang, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.