메뉴 건너뛰기




Volumn 389, Issue 10066, 2017, Pages 299-311

Lung cancer: current therapies and new targeted treatments

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR;

EID: 84994087188     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(16)30958-8     Document Type: Review
Times cited : (2592)

References (152)
  • 1
    • 84918815964 scopus 로고    scopus 로고
    • Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012
    • 1 Ferlay, J, Soerjomataram, I, Dikshit, R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136 (2015), E359–E386.
    • (2015) Int J Cancer , vol.136 , pp. E359-E386
    • Ferlay, J.1    Soerjomataram, I.2    Dikshit, R.3
  • 2
    • 84977558311 scopus 로고    scopus 로고
    • American Cancer Society Atlanta (accessed Dec 31, 2015).
    • 2 American Cancer Society. Cancer facts & figures 2015, 2015, American Cancer Society, Atlanta http://www.cancer.org/acs/groups/content/@editorial/documents/document/acspc-044552.pdf (accessed Dec 31, 2015).
    • (2015) Cancer facts & figures 2015
  • 3
    • 79961108629 scopus 로고    scopus 로고
    • Reduced lung-cancer mortality with low-dose computed tomographic screening
    • 3 Aberle, DR, Adams, AM, Berg, CD, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 365 (2011), 395–409.
    • (2011) N Engl J Med , vol.365 , pp. 395-409
    • Aberle, D.R.1    Adams, A.M.2    Berg, C.D.3
  • 4
    • 84908574660 scopus 로고    scopus 로고
    • Lung cancer probability in patients with CT-detected pulmonary nodules: a pre-specified analysis of data from the NELSON trial of low-dose CT screening
    • 4 Horeweg, N, van Rosmalen, J, Heuvelmans, MA, et al. Lung cancer probability in patients with CT-detected pulmonary nodules: a pre-specified analysis of data from the NELSON trial of low-dose CT screening. Lancet Oncol 15 (2014), 1332–1341.
    • (2014) Lancet Oncol , vol.15 , pp. 1332-1341
    • Horeweg, N.1    van Rosmalen, J.2    Heuvelmans, M.A.3
  • 5
    • 84958952298 scopus 로고    scopus 로고
    • UK lung cancer RCT pilot screening trial: baseline findings from the screening arm provide evidence for the potential implementation of lung cancer screening
    • 5 Field, JK, Duffy, SW, Baldwin, DR, et al. UK lung cancer RCT pilot screening trial: baseline findings from the screening arm provide evidence for the potential implementation of lung cancer screening. Thorax 71 (2015), 161–170.
    • (2015) Thorax , vol.71 , pp. 161-170
    • Field, J.K.1    Duffy, S.W.2    Baldwin, D.R.3
  • 6
    • 84874385423 scopus 로고    scopus 로고
    • Definition of a positive test result in computed tomography screening for lung cancer: a cohort study
    • 6 Henschke, C, Yip, R, Yankelevitz, DF, et al. Definition of a positive test result in computed tomography screening for lung cancer: a cohort study. Ann Intern Med 158 (2013), 246–252.
    • (2013) Ann Intern Med , vol.158 , pp. 246-252
    • Henschke, C.1    Yip, R.2    Yankelevitz, D.F.3
  • 7
    • 84920494218 scopus 로고    scopus 로고
    • ACR CT accreditation program and the lung cancer screening program designation
    • 7 Kazerooni, EA, Armstrong, MR, Amorosa, JK, et al. ACR CT accreditation program and the lung cancer screening program designation. J Am Coll Radiol 12 (2015), 38–42.
    • (2015) J Am Coll Radiol , vol.12 , pp. 38-42
    • Kazerooni, E.A.1    Armstrong, M.R.2    Amorosa, J.K.3
  • 8
    • 84926609696 scopus 로고    scopus 로고
    • Performance of Lung-RADS in the National Lung Screening Trial: a retrospective assessment
    • 8 Pinsky, PF, Gierada, DS, Black, W, et al. Performance of Lung-RADS in the National Lung Screening Trial: a retrospective assessment. Ann Intern Med 162 (2015), 485–591.
    • (2015) Ann Intern Med , vol.162 , pp. 485-591
    • Pinsky, P.F.1    Gierada, D.S.2    Black, W.3
  • 10
    • 79955571953 scopus 로고    scopus 로고
    • Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases
    • 10 Yoshizawa, A, Motoi, N, Riely, GJ, et al. Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases. Mod Pathol 24 (2011), 653–664.
    • (2011) Mod Pathol , vol.24 , pp. 653-664
    • Yoshizawa, A.1    Motoi, N.2    Riely, G.J.3
  • 11
    • 84939623045 scopus 로고    scopus 로고
    • CT screening for lung cancer: nonsolid nodules in baseline and annual repeat rounds
    • 11 Yankelevitz, DF, Yip, R, Smith, JP, et al. CT screening for lung cancer: nonsolid nodules in baseline and annual repeat rounds. Radiology 277 (2015), 555–564.
    • (2015) Radiology , vol.277 , pp. 555-564
    • Yankelevitz, D.F.1    Yip, R.2    Smith, J.P.3
  • 12
    • 84908129426 scopus 로고    scopus 로고
    • Issues with implementing a high-quality lung cancer screening program
    • 12 Mulshine, JL, D'Amico, A, Issues with implementing a high-quality lung cancer screening program. CA Cancer J Clin 64 (2014), 352–363.
    • (2014) CA Cancer J Clin , vol.64 , pp. 352-363
    • Mulshine, J.L.1    D'Amico, A.2
  • 13
    • 84899911753 scopus 로고    scopus 로고
    • Balancing curability and unnecessary surgery in the context of computed tomography screening for lung cancer
    • 13 Flores, R, Bauer, T, Aye, R, et al. Balancing curability and unnecessary surgery in the context of computed tomography screening for lung cancer. J Thorac Cardiovasc Surg 147 (2014), 1619–1626.
    • (2014) J Thorac Cardiovasc Surg , vol.147 , pp. 1619-1626
    • Flores, R.1    Bauer, T.2    Aye, R.3
  • 14
    • 84881350116 scopus 로고    scopus 로고
    • A cost-utility analysis of lung cancer screening and the additional benefits of incorporating smoking cessation interventions
    • 14 Villanti, AC, Jiang, Y, Abrams, DB, Pyenson, BS, A cost-utility analysis of lung cancer screening and the additional benefits of incorporating smoking cessation interventions. PLoS One, 8, 2013, e71379.
    • (2013) PLoS One , vol.8 , pp. e71379
    • Villanti, A.C.1    Jiang, Y.2    Abrams, D.B.3    Pyenson, B.S.4
  • 15
    • 84964969336 scopus 로고    scopus 로고
    • Readiness of lung cancer screening sites to deliver smoking cessation treatment: current practices, organizational priority, and perceived barriers
    • 15 Ostroff, JS, Copeland, A, Borderud, SP, Li, Y, Shelley, DR, Henschke, CI, Readiness of lung cancer screening sites to deliver smoking cessation treatment: current practices, organizational priority, and perceived barriers. Nicotine Tob Res 18 (2015), 1067–1075.
    • (2015) Nicotine Tob Res , vol.18 , pp. 1067-1075
    • Ostroff, J.S.1    Copeland, A.2    Borderud, S.P.3    Li, Y.4    Shelley, D.R.5    Henschke, C.I.6
  • 16
    • 84945437888 scopus 로고    scopus 로고
    • China national lung cancer screening guideline with low-dose computed tomography (2015 version)
    • 16 Zhou, QH, Fan, YG, Bu, H, et al. China national lung cancer screening guideline with low-dose computed tomography (2015 version). Thorac Cancer 6 (2015), 812–818.
    • (2015) Thorac Cancer , vol.6 , pp. 812-818
    • Zhou, Q.H.1    Fan, Y.G.2    Bu, H.3
  • 17
    • 84962690671 scopus 로고    scopus 로고
    • Recommendations on screening for lung cancer
    • 17 Canadian Task Force on Preventive Health Care. Recommendations on screening for lung cancer. CMAJ 188 (2016), 425–432.
    • (2016) CMAJ , vol.188 , pp. 425-432
  • 18
    • 0021739565 scopus 로고
    • Screening for lung cancer—where are we now?
    • 18 Bailar, JC, Screening for lung cancer—where are we now?. Am Rev Respir Dis 130 (1984), 541–542.
    • (1984) Am Rev Respir Dis , vol.130 , pp. 541-542
    • Bailar, J.C.1
  • 19
    • 84904545741 scopus 로고    scopus 로고
    • 2nd ESMO Consensus Conference on Lung Cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up
    • 19 Vansteenkiste, J, Crinò, L, Dooms, C, et al. 2nd ESMO Consensus Conference on Lung Cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up. Ann Oncol 25 (2014), 1462–1474.
    • (2014) Ann Oncol , vol.25 , pp. 1462-1474
    • Vansteenkiste, J.1    Crinò, L.2    Dooms, C.3
  • 20
    • 84959324583 scopus 로고    scopus 로고
    • The IASLC Lung Cancer Staging Project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer
    • 20 Goldstraw, P, Chansky, K, Crowley, J, et al. The IASLC Lung Cancer Staging Project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol 11 (2016), 39–51.
    • (2016) J Thorac Oncol , vol.11 , pp. 39-51
    • Goldstraw, P.1    Chansky, K.2    Crowley, J.3
  • 21
    • 84874311289 scopus 로고    scopus 로고
    • Video-assisted thoracic surgery versus open thoracotomy for non-small cell lung cancer: a meta-analysis of propensity score-matched patients
    • 21 Cao, C, Manganas, C, Ang, SC, Peeceeyen, S, Yan, TD, Video-assisted thoracic surgery versus open thoracotomy for non-small cell lung cancer: a meta-analysis of propensity score-matched patients. Interact Cardiovasc Thorac Surg 16 (2013), 244–249.
    • (2013) Interact Cardiovasc Thorac Surg , vol.16 , pp. 244-249
    • Cao, C.1    Manganas, C.2    Ang, S.C.3    Peeceeyen, S.4    Yan, T.D.5
  • 22
    • 49049109683 scopus 로고    scopus 로고
    • Lung adjuvant cisplatin evaluation: a pooled analysis from the LACE Collaborative Group
    • 22 Pignon, JP, Tribodet, H, Scagliotti, GV, et al. Lung adjuvant cisplatin evaluation: a pooled analysis from the LACE Collaborative Group. J Clin Oncol 26 (2008), 3552–3559.
    • (2008) J Clin Oncol , vol.26 , pp. 3552-3559
    • Pignon, J.P.1    Tribodet, H.2    Scagliotti, G.V.3
  • 23
    • 84900022149 scopus 로고    scopus 로고
    • Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data
    • 23 NSCLC Meta-analysis Collaborative Group. Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data. Lancet 383 (2014), 1561–1571.
    • (2014) Lancet , vol.383 , pp. 1561-1571
  • 24
    • 84948384227 scopus 로고    scopus 로고
    • Adjuvant erlotinib versus placebo in patients with stage IB–IIIA non-small cell lung cancer (RADIANT): a randomized, double-blind, phase III trial
    • 24 Kelly, K, Altorki, NK, Eberhardt, WE, et al. Adjuvant erlotinib versus placebo in patients with stage IB–IIIA non-small cell lung cancer (RADIANT): a randomized, double-blind, phase III trial. J Clin Oncol 33 (2015), 4007–4014.
    • (2015) J Clin Oncol , vol.33 , pp. 4007-4014
    • Kelly, K.1    Altorki, N.K.2    Eberhardt, W.E.3
  • 25
    • 84948379595 scopus 로고    scopus 로고
    • Adjuvant TKIs in NSCLC: what can we learn from RADIANT?
    • 25 Hirsch, FR, Bunn, PA Jr, Adjuvant TKIs in NSCLC: what can we learn from RADIANT?. Nat Rev Clin Oncol 12 (2015), 689–690.
    • (2015) Nat Rev Clin Oncol , vol.12 , pp. 689-690
    • Hirsch, F.R.1    Bunn, P.A.2
  • 27
    • 84890896341 scopus 로고    scopus 로고
    • Gefitinib versus placebo in completely resected non-small cell lung cancer; result of the NCIC-CTG BR 19 study
    • 27 Goss, GD, O'Callaghan, C, Lorimer, I, et al. Gefitinib versus placebo in completely resected non-small cell lung cancer; result of the NCIC-CTG BR 19 study. J Clin Oncol 31 (2013), 3320–3326.
    • (2013) J Clin Oncol , vol.31 , pp. 3320-3326
    • Goss, G.D.1    O'Callaghan, C.2    Lorimer, I.3
  • 28
    • 85009924053 scopus 로고    scopus 로고
    • ALCHEMIST (Adjuvant Lung Cancer Enhancement Marker Identification and Sequencing Trials)
    • (accessed March 25, 2016).
    • 28 National Cancer Institute. ALCHEMIST (Adjuvant Lung Cancer Enhancement Marker Identification and Sequencing Trials). http//www.cancer.gov/types/lung/research/alchemist (accessed March 25, 2016).
  • 29
    • 77949520655 scopus 로고    scopus 로고
    • Stereotactic body radiation therapy for inoperable early stage lung cancer
    • 29 Timmerman, R, Paulus, R, Galvin, J, et al. Stereotactic body radiation therapy for inoperable early stage lung cancer. JAMA 303 (2010), 1070–1076.
    • (2010) JAMA , vol.303 , pp. 1070-1076
    • Timmerman, R.1    Paulus, R.2    Galvin, J.3
  • 30
    • 68049136288 scopus 로고    scopus 로고
    • Stereotactic body radiation therapy for early-stage non-small-cell lung carcinoma: four-year results of a prospective phase II study
    • 30 Fakiris, AJ, McGarry, RC, Yiannoutsos, CT, et al. Stereotactic body radiation therapy for early-stage non-small-cell lung carcinoma: four-year results of a prospective phase II study. Int J Radiat Oncol Biol Phys 75 (2009), 677–682.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , pp. 677-682
    • Fakiris, A.J.1    McGarry, R.C.2    Yiannoutsos, C.T.3
  • 31
    • 80054072961 scopus 로고    scopus 로고
    • Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410
    • 31 Curran, WJ Jr, Paulus, R, Langer, CJ, et al. Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410. J Natl Cancer Inst 103 (2011), 1452–1460.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 1452-1460
    • Curran, W.J.1    Paulus, R.2    Langer, C.J.3
  • 32
    • 77952298828 scopus 로고    scopus 로고
    • Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer
    • 32 Auperin, A, Pechoux, C, Rolland, E, et al. Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. J Clin Oncol 28 (2010), 2181–2190.
    • (2010) J Clin Oncol , vol.28 , pp. 2181-2190
    • Auperin, A.1    Pechoux, C.2    Rolland, E.3
  • 33
    • 84921842851 scopus 로고    scopus 로고
    • A randomized phase III comparison of standard-dose (60 Gy) versus high-dose (74 Gy) conformal radiotherapy with concurrent and consolidation carboplatin/paclitaxel with or without cetuximab for patients with stage IIIA/IIIB non-small cell lung cancer: RTOG 0617
    • 33 Bradley, J, Paulus, R, Komaki, R, et al. A randomized phase III comparison of standard-dose (60 Gy) versus high-dose (74 Gy) conformal radiotherapy with concurrent and consolidation carboplatin/paclitaxel with or without cetuximab for patients with stage IIIA/IIIB non-small cell lung cancer: RTOG 0617. Lancet Oncol 16 (2015), 187–199.
    • (2015) Lancet Oncol , vol.16 , pp. 187-199
    • Bradley, J.1    Paulus, R.2    Komaki, R.3
  • 34
    • 84962118514 scopus 로고    scopus 로고
    • PROCLAIM: Randomized phase III trial of pemetrexed-cisplatin or etoposide-cisplatin plus thoracic radiation therapy followed by consolidation chemotherapy in locally advanced nonsquamous non-small-cell lung cancer
    • 34 Senan, S, Brade, A, Wang, LH, et al. PROCLAIM: Randomized phase III trial of pemetrexed-cisplatin or etoposide-cisplatin plus thoracic radiation therapy followed by consolidation chemotherapy in locally advanced nonsquamous non-small-cell lung cancer. J Clin Oncol 34 (2016), 953–962.
    • (2016) J Clin Oncol , vol.34 , pp. 953-962
    • Senan, S.1    Brade, A.2    Wang, L.H.3
  • 35
    • 84969833490 scopus 로고    scopus 로고
    • Scientific advances in lung cancer 2015
    • 35 Tsao, AS, Scagliotti, GV, Bunn, PA Jr, et al. Scientific advances in lung cancer 2015. J Thorac Oncol 11 (2016), 613–638.
    • (2016) J Thorac Oncol , vol.11 , pp. 613-638
    • Tsao, A.S.1    Scagliotti, G.V.2    Bunn, P.A.3
  • 36
    • 84978264610 scopus 로고    scopus 로고
    • The International Association for the Study of Lung Cancer consensus statement on optimizing management of EGFR mutation positive NSCLC: status in 2016
    • 36 Tan, DSW, Yom, SS, Tsao, MS, et al. The International Association for the Study of Lung Cancer consensus statement on optimizing management of EGFR mutation positive NSCLC: status in 2016. J Thorac Oncol 11 (2016), 946–963.
    • (2016) J Thorac Oncol , vol.11 , pp. 946-963
    • Tan, D.S.W.1    Yom, S.S.2    Tsao, M.S.3
  • 37
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
    • 37 Rosell, R, Carcereny, E, Gervais, R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 13 (2012), 239–246.
    • (2012) Lancet Oncol , vol.13 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 38
    • 84964389363 scopus 로고    scopus 로고
    • Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-Lung 7): a phase 2B, open-label, randomised controlled trial
    • 38 Park, K, Tan, E-H, O'Byrne, K, et al. Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-Lung 7): a phase 2B, open-label, randomised controlled trial. Lancet Oncol 17 (2016), 577–589.
    • (2016) Lancet Oncol , vol.17 , pp. 577-589
    • Park, K.1    Tan, E.-H.2    O'Byrne, K.3
  • 39
    • 84928739294 scopus 로고    scopus 로고
    • AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer
    • 39 Jänne, PA, Yang, JC, Kim, DW, et al. AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer. N Engl J Med 372 (2015), 1689–1699.
    • (2015) N Engl J Med , vol.372 , pp. 1689-1699
    • Jänne, P.A.1    Yang, J.C.2    Kim, D.W.3
  • 40
    • 84938905136 scopus 로고    scopus 로고
    • Rociletinib in EGFR-mutated non-small-cell lung cancer
    • 40 Sequist, LV, Rolfe, L, Allen, AR, Rociletinib in EGFR-mutated non-small-cell lung cancer. N Engl J Med 373 (2015), 578–579.
    • (2015) N Engl J Med , vol.373 , pp. 578-579
    • Sequist, L.V.1    Rolfe, L.2    Allen, A.R.3
  • 41
    • 84871720411 scopus 로고    scopus 로고
    • Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study
    • 41 Jänne, PA, Shaw, AT, Pereira, JR, et al. Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study. Lancet Oncol 14 (2013), 38–47.
    • (2013) Lancet Oncol , vol.14 , pp. 38-47
    • Jänne, P.A.1    Shaw, A.T.2    Pereira, J.R.3
  • 42
    • 84947338095 scopus 로고    scopus 로고
    • Oral MEK1/MEK2 inhibitor trametinib (GSK1120212) in combination with pemetrexed in a phase 1/1B trial involving KRAS-mutant and wild-type (WT) advanced non-small cell lung cancer (NSCLC): efficacy and biomarker results
    • 42 Mazières, J, Gandara, SR, Leighl, NB, et al. Oral MEK1/MEK2 inhibitor trametinib (GSK1120212) in combination with pemetrexed in a phase 1/1B trial involving KRAS-mutant and wild-type (WT) advanced non-small cell lung cancer (NSCLC): efficacy and biomarker results. J Thorac Oncol, 8, 2013, 2922.
    • (2013) J Thorac Oncol , vol.8 , pp. 2922
    • Mazières, J.1    Gandara, S.R.2    Leighl, N.B.3
  • 43
    • 80053014471 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations
    • 43 Marchetti, A, Felicioni, L, Malatesta, S, et al. Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations. J Clin Oncol 29 (2011), 3574–3579.
    • (2011) J Clin Oncol , vol.29 , pp. 3574-3579
    • Marchetti, A.1    Felicioni, L.2    Malatesta, S.3
  • 44
    • 79956316170 scopus 로고    scopus 로고
    • Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
    • 44 Paik, PK, Arcila, ME, Fara, M, et al. Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J Clin Oncol 29 (2011), 2046–2051.
    • (2011) J Clin Oncol , vol.29 , pp. 2046-2051
    • Paik, P.K.1    Arcila, M.E.2    Fara, M.3
  • 45
    • 84939864059 scopus 로고    scopus 로고
    • Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations
    • 45 Hyman, DM, Puzanov, I, Subbiah, V, et al. Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations. N Engl J Med 373 (2015), 726–736.
    • (2015) N Engl J Med , vol.373 , pp. 726-736
    • Hyman, D.M.1    Puzanov, I.2    Subbiah, V.3
  • 46
    • 84964329499 scopus 로고    scopus 로고
    • Dabrafenib in patients with BRAFV600E -positive advanced non-small-cell lung cancer: a single-arm, multicentre, open-label, phase 2 trial
    • 46 Planchard, D, Kim, TM, Mazieres, J, et al. Dabrafenib in patients with BRAFV600E -positive advanced non-small-cell lung cancer: a single-arm, multicentre, open-label, phase 2 trial. Lancet Oncol 17 (2016), 642–650.
    • (2016) Lancet Oncol , vol.17 , pp. 642-650
    • Planchard, D.1    Kim, T.M.2    Mazieres, J.3
  • 47
    • 84880661427 scopus 로고    scopus 로고
    • Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives
    • 47 Mazières, J, Peters, S, Lepage, B, et al. Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives. J Clin Oncol 31 (2013), 1997–2003.
    • (2013) J Clin Oncol , vol.31 , pp. 1997-2003
    • Mazières, J.1    Peters, S.2    Lepage, B.3
  • 48
    • 84946710397 scopus 로고    scopus 로고
    • Targeting HER2 aberrations as actionable drivers in lung cancers: phase II trial of the pan-HER tyrosine kinase inhibitor dacomitinib in patients with HER2-mutant or amplified tumors
    • 48 Kris, MG, Camidge, DR, Giaccone, G, et al. Targeting HER2 aberrations as actionable drivers in lung cancers: phase II trial of the pan-HER tyrosine kinase inhibitor dacomitinib in patients with HER2-mutant or amplified tumors. Ann Oncol 26 (2015), 1421–1427.
    • (2015) Ann Oncol , vol.26 , pp. 1421-1427
    • Kris, M.G.1    Camidge, D.R.2    Giaccone, G.3
  • 49
    • 84875914687 scopus 로고    scopus 로고
    • MET as a possible target for non-small-cell lung cancer
    • 49 Sadiq, AA, Salgia, R, MET as a possible target for non-small-cell lung cancer. J Clin Oncol 31 (2013), 1089–1096.
    • (2013) J Clin Oncol , vol.31 , pp. 1089-1096
    • Sadiq, A.A.1    Salgia, R.2
  • 50
    • 84938815085 scopus 로고    scopus 로고
    • Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping
    • 50 Paik, PK, Drilon, A, Fan, PD, et al. Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping. Cancer Discov 5 (2015), 842–849.
    • (2015) Cancer Discov , vol.5 , pp. 842-849
    • Paik, P.K.1    Drilon, A.2    Fan, P.D.3
  • 51
    • 70349336416 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
    • 51 Shaw, AT, Yeap, BY, Mino-Kenudson, M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol 27 (2009), 4247–4253.
    • (2009) J Clin Oncol , vol.27 , pp. 4247-4253
    • Shaw, A.T.1    Yeap, B.Y.2    Mino-Kenudson, M.3
  • 52
    • 84939575246 scopus 로고    scopus 로고
    • Therapeutic targeting of anaplastic lymphoma kinase in lung cancer: a paradigm for precision cancer medicine
    • 52 Katayama, R, Lovly, CM, Shaw, AT, Therapeutic targeting of anaplastic lymphoma kinase in lung cancer: a paradigm for precision cancer medicine. Clin Cancer Res 21 (2015), 2227–2235.
    • (2015) Clin Cancer Res , vol.21 , pp. 2227-2235
    • Katayama, R.1    Lovly, C.M.2    Shaw, A.T.3
  • 53
    • 84881256393 scopus 로고    scopus 로고
    • ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: an analysis of 1,683 patients with non-small cell lung cancer
    • 53 Gainor, JF, Varghese, AM, Ou, SH, et al. ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: an analysis of 1,683 patients with non-small cell lung cancer. Clin Cancer Res 19 (2013), 4273–4281.
    • (2013) Clin Cancer Res , vol.19 , pp. 4273-4281
    • Gainor, J.F.1    Varghese, A.M.2    Ou, S.H.3
  • 54
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • 54 Shaw, AT, Kim, DW, Nakagawa, K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 368 (2013), 2385–2394.
    • (2013) N Engl J Med , vol.368 , pp. 2385-2394
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3
  • 55
    • 84918804764 scopus 로고    scopus 로고
    • Firstline crizotinib versus chemotherapy in ALK-positive lung cancer
    • 55 Solomon, BJ, Mok, T, Kim, DW, et al. Firstline crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med 371 (2014), 2167–2177.
    • (2014) N Engl J Med , vol.371 , pp. 2167-2177
    • Solomon, B.J.1    Mok, T.2    Kim, D.W.3
  • 56
    • 84903482432 scopus 로고    scopus 로고
    • Ceritinib in ALK-rearranged non-small-cell lung cancer
    • 56 Shaw, AT, Kim, DW, Mehra, R, et al. Ceritinib in ALK-rearranged non-small-cell lung cancer. N Engl J Med 370 (2014), 1189–1197.
    • (2014) N Engl J Med , vol.370 , pp. 1189-1197
    • Shaw, A.T.1    Kim, D.W.2    Mehra, R.3
  • 57
    • 84908569219 scopus 로고    scopus 로고
    • Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study
    • 57 Gadgeel, SM, Gandhi, L, Riely, GJ, et al. Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study. Lancet Oncol 15 (2014), 1119–1128.
    • (2014) Lancet Oncol , vol.15 , pp. 1119-1128
    • Gadgeel, S.M.1    Gandhi, L.2    Riely, G.J.3
  • 58
    • 84961943154 scopus 로고    scopus 로고
    • ALK Inhibitor AP26113 in patients with advanced malignancies, including ALK+ non-small cell lung cancer (NSCLC): updated efficacy and safety data
    • 58 Gettinger, S, Bazhenova, L, Salgia, R, et al. ALK Inhibitor AP26113 in patients with advanced malignancies, including ALK+ non-small cell lung cancer (NSCLC): updated efficacy and safety data. Ann Oncol 25 (2014), iv426–iv470.
    • (2014) Ann Oncol , vol.25 , pp. iv426-iv470
    • Gettinger, S.1    Bazhenova, L.2    Salgia, R.3
  • 59
    • 84925307919 scopus 로고    scopus 로고
    • PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations
    • 59 Zou, HY, Li, Q, Engstrom, LD, et al. PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations. Proc Natl Acad Sci USA 112 (2015), 3493–3498.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. 3493-3498
    • Zou, H.Y.1    Li, Q.2    Engstrom, L.D.3
  • 60
    • 84863338079 scopus 로고    scopus 로고
    • ROS1 rearrangements define a unique molecular class of lung cancers
    • 60 Bergethon, K, Shaw, AT, Ou, SH, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol 30 (2012), 863–870.
    • (2012) J Clin Oncol , vol.30 , pp. 863-870
    • Bergethon, K.1    Shaw, A.T.2    Ou, S.H.3
  • 61
    • 84911372597 scopus 로고    scopus 로고
    • Crizotinib in ROS1-rearranged non-small-cell lung cancer
    • 61 Shaw, AT, Ou, SH, Bang, YJ, et al. Crizotinib in ROS1-rearranged non-small-cell lung cancer. N Engl J Med 371 (2014), 1963–1971.
    • (2014) N Engl J Med , vol.371 , pp. 1963-1971
    • Shaw, A.T.1    Ou, S.H.2    Bang, Y.J.3
  • 62
    • 84922975873 scopus 로고    scopus 로고
    • ROS1 immunohistochemistry among major genotypes of non-small-cell lung cancer
    • 62 Boyle, TA, Masago, K, Ellison, KE, Yatabe, Y, Hirsch, FR, ROS1 immunohistochemistry among major genotypes of non-small-cell lung cancer. Clin Lung Cancer 16 (2015), 106–111.
    • (2015) Clin Lung Cancer , vol.16 , pp. 106-111
    • Boyle, T.A.1    Masago, K.2    Ellison, K.E.3    Yatabe, Y.4    Hirsch, F.R.5
  • 63
    • 84927139647 scopus 로고    scopus 로고
    • Crizotinib therapy for advanced lung adenocarcinoma and a ROS1 rearrangement: results from the EUROS1 cohort
    • 63 Mazières, J, Zalcman, G, Crinò, L, et al. Crizotinib therapy for advanced lung adenocarcinoma and a ROS1 rearrangement: results from the EUROS1 cohort. J Clin Oncol 33 (2015), 992–999.
    • (2015) J Clin Oncol , vol.33 , pp. 992-999
    • Mazières, J.1    Zalcman, G.2    Crinò, L.3
  • 64
    • 84879088863 scopus 로고    scopus 로고
    • Acquired resistance to crizotinib from a mutation in CD74-ROS1
    • 64 Awad, MM, Katayama, R, McTigue, M, et al. Acquired resistance to crizotinib from a mutation in CD74-ROS1. N Engl J Med 368 (2013), 2395–2401.
    • (2013) N Engl J Med , vol.368 , pp. 2395-2401
    • Awad, M.M.1    Katayama, R.2    McTigue, M.3
  • 65
    • 84906272121 scopus 로고    scopus 로고
    • ALK and crizotinib: after the honeymoon…what else? Resistance mechanisms and new therapies to overcome it
    • 65 Rolfo, C, Passiglia, F, Castiglia, M, et al. ALK and crizotinib: after the honeymoon…what else? Resistance mechanisms and new therapies to overcome it. Transl Lung Cancer Res 3 (2014), 250–261.
    • (2014) Transl Lung Cancer Res , vol.3 , pp. 250-261
    • Rolfo, C.1    Passiglia, F.2    Castiglia, M.3
  • 66
    • 84937512084 scopus 로고    scopus 로고
    • Beyond EGFR and ALK inhibition: unravelling and exploiting novel genetic alterations in advanced non small-cell lung cancer
    • 66 Califano, R, Abidin, A, Tariq, NU, Economopoulou, P, Metro, G, Mountzios, G, Beyond EGFR and ALK inhibition: unravelling and exploiting novel genetic alterations in advanced non small-cell lung cancer. Cancer Treat Rev 41 (2015), 401–411.
    • (2015) Cancer Treat Rev , vol.41 , pp. 401-411
    • Califano, R.1    Abidin, A.2    Tariq, N.U.3    Economopoulou, P.4    Metro, G.5    Mountzios, G.6
  • 67
    • 84878858856 scopus 로고    scopus 로고
    • Response to cabozantinib in patients with RET fusion-positive lung adenocarcinomas
    • 67 Drilon, A, Wang, L, Hasanovic, A, et al. Response to cabozantinib in patients with RET fusion-positive lung adenocarcinomas. Cancer Discov 3 (2013), 630–635.
    • (2013) Cancer Discov , vol.3 , pp. 630-635
    • Drilon, A.1    Wang, L.2    Hasanovic, A.3
  • 68
    • 84938650566 scopus 로고    scopus 로고
    • Phase II study of cabozantinib for patients with advanced RET-rearranged lung cancers
    • (abstr).
    • 68 Drilon, A, Sima, CS, Somwar, R, et al. Phase II study of cabozantinib for patients with advanced RET-rearranged lung cancers. J Clin Oncol, 33, 2015, 8007 (abstr).
    • (2015) J Clin Oncol , vol.33 , pp. 8007
    • Drilon, A.1    Sima, C.S.2    Somwar, R.3
  • 69
    • 84943338865 scopus 로고    scopus 로고
    • An oncogenic NTRK fusion in a patient with soft-tissue sarcoma with response to the tropomyosin-related kinase inhibitor LOXO-101
    • 69 Doebele, RC, Davis, LE, Vaishnavi, A, et al. An oncogenic NTRK fusion in a patient with soft-tissue sarcoma with response to the tropomyosin-related kinase inhibitor LOXO-101. Cancer Discov 5 (2015), 1049–1057.
    • (2015) Cancer Discov , vol.5 , pp. 1049-1057
    • Doebele, R.C.1    Davis, L.E.2    Vaishnavi, A.3
  • 70
    • 84902811306 scopus 로고    scopus 로고
    • Efficacy and safety of crizotinib in patients with advanced c-MET-amplified non-small cell lung cancer (NSCLC)
    • (abstr).
    • 70 Camidge, DR, Ou, SD, Shapiro, G, et al. Efficacy and safety of crizotinib in patients with advanced c-MET-amplified non-small cell lung cancer (NSCLC). J Clin Oncol, 32, 2014, 8001 (abstr).
    • (2014) J Clin Oncol , vol.32 , pp. 8001
    • Camidge, D.R.1    Ou, S.D.2    Shapiro, G.3
  • 71
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • 71 Shigematsu, H, Lin, L, Takahashi, T, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 97 (2005), 339–346.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3
  • 72
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
    • 72 Mitsudomi, T, Morita, S, Yatabe, Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 11 (2010), 121–128.
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 73
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • 73 Sequist, LV, Yang, JC, Yamamoto, N, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol 31 (2013), 3327–3334.
    • (2013) J Clin Oncol , vol.31 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.2    Yamamoto, N.3
  • 74
    • 84941629860 scopus 로고    scopus 로고
    • First-line erlotinib versus gemcitabine/cisplatin in patients with advanced EGFR mutation-positive non-small-cell lung cancer: analyses from the phase III, randomized, open-label, ENSURE study
    • 74 Wu, Y-L, Zhou, C, Liam, CK, et al. First-line erlotinib versus gemcitabine/cisplatin in patients with advanced EGFR mutation-positive non-small-cell lung cancer: analyses from the phase III, randomized, open-label, ENSURE study. Ann Oncol 26 (2015), 1883–1889.
    • (2015) Ann Oncol , vol.26 , pp. 1883-1889
    • Wu, Y.-L.1    Zhou, C.2    Liam, C.K.3
  • 75
    • 84937513065 scopus 로고    scopus 로고
    • Clinical activity of afatinib in patients with advanced non-small-cell lung cancer harbouring uncommon EGFR mutations: a combined post-hoc analysis of LUX-Lung 2, LUX-Lung 3, and LUX-Lung 6
    • 75 Yang, JC, Sequist, LV, Geater, SL, et al. Clinical activity of afatinib in patients with advanced non-small-cell lung cancer harbouring uncommon EGFR mutations: a combined post-hoc analysis of LUX-Lung 2, LUX-Lung 3, and LUX-Lung 6. Lancet Oncol 16 (2015), 830–838.
    • (2015) Lancet Oncol , vol.16 , pp. 830-838
    • Yang, J.C.1    Sequist, L.V.2    Geater, S.L.3
  • 76
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    • 76 Sequist, LV, Waltman, BA, Dias-Santagata, D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med, 3, 2011, 75ra26.
    • (2011) Sci Transl Med , vol.3 , pp. 75ra26
    • Sequist, L.V.1    Waltman, B.A.2    Dias-Santagata, D.3
  • 77
    • 84937414146 scopus 로고    scopus 로고
    • Heterogeneity underlies the emergence of EGFRT790 wild-type clones following treatment of T790M-positive cancers with a third-generation EGFR inhibitor
    • 77 Piotrowska, Z, Niederst, MJ, Karlovich, CA, et al. Heterogeneity underlies the emergence of EGFRT790 wild-type clones following treatment of T790M-positive cancers with a third-generation EGFR inhibitor. Cancer Discov 5 (2015), 713–722.
    • (2015) Cancer Discov , vol.5 , pp. 713-722
    • Piotrowska, Z.1    Niederst, M.J.2    Karlovich, C.A.3
  • 78
    • 84942159464 scopus 로고    scopus 로고
    • Updated safety and efficacy results from phase I/II study of HM61713 in patients (pts) with EGFR mutation positive non-small cell lung cancer (NSCLC) who failed previous EGFR-tyrosine kinase inhibitor (TKI)
    • (abstr).
    • 78 Park, K, Lee, JS, Lee, KH, et al. Updated safety and efficacy results from phase I/II study of HM61713 in patients (pts) with EGFR mutation positive non-small cell lung cancer (NSCLC) who failed previous EGFR-tyrosine kinase inhibitor (TKI). J Clin Oncol, 33, 2015, 8084 (abstr).
    • (2015) J Clin Oncol , vol.33 , pp. 8084
    • Park, K.1    Lee, J.S.2    Lee, K.H.3
  • 79
    • 84871087595 scopus 로고    scopus 로고
    • Clinical modes of EGFR tyrosine kinase inhibitor failure and subsequent management in advanced non-small cell lung cancer
    • 79 Yang, JJ, Chen, HJ, Yan, HH, et al. Clinical modes of EGFR tyrosine kinase inhibitor failure and subsequent management in advanced non-small cell lung cancer. Lung Cancer 79 (2013), 33–39.
    • (2013) Lung Cancer , vol.79 , pp. 33-39
    • Yang, J.J.1    Chen, H.J.2    Yan, H.H.3
  • 80
    • 84870317390 scopus 로고    scopus 로고
    • Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer
    • 80 Weickhardt, AJ, Scheier, B, Burke, JM, et al. Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer. J Thorac Oncol 7 (2012), 1807–1814.
    • (2012) J Thorac Oncol , vol.7 , pp. 1807-1814
    • Weickhardt, A.J.1    Scheier, B.2    Burke, J.M.3
  • 81
    • 84979503381 scopus 로고    scopus 로고
    • First-line erlotinib therapy until and beyond response evaluation criteria in solid tumors progression in Asian patients with epidermal growth factor receptor mutation–positive non–small-cell lung cancer: the ASPIRATION study
    • 81 Park, K, Yu, CJ, Kim, SW, et al. First-line erlotinib therapy until and beyond response evaluation criteria in solid tumors progression in Asian patients with epidermal growth factor receptor mutation–positive non–small-cell lung cancer: the ASPIRATION study. JAMA Oncol 2 (2016), 305–312.
    • (2016) JAMA Oncol , vol.2 , pp. 305-312
    • Park, K.1    Yu, C.J.2    Kim, S.W.3
  • 82
    • 84938208051 scopus 로고    scopus 로고
    • Gefitinib plus chemotherapy versus placebo plus chemotherapy in EGFR-mutation-positive non-small-cell lung cancer after progression on first-line gefitinib (IMPRESS): a phase 3 randomised trial
    • 82 Soria, JC, Wu, Y-L, Nakagawa, K, et al. Gefitinib plus chemotherapy versus placebo plus chemotherapy in EGFR-mutation-positive non-small-cell lung cancer after progression on first-line gefitinib (IMPRESS): a phase 3 randomised trial. Lancet Oncol 16 (2015), 990–998.
    • (2015) Lancet Oncol , vol.16 , pp. 990-998
    • Soria, J.C.1    Wu, Y.-L.2    Nakagawa, K.3
  • 83
    • 84930755018 scopus 로고    scopus 로고
    • Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M
    • 83 Thress, KS, Paweletz, CP, Felip, E, et al. Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M. Nat Med 21 (2015), 560–562.
    • (2015) Nat Med , vol.21 , pp. 560-562
    • Thress, K.S.1    Paweletz, C.P.2    Felip, E.3
  • 84
    • 84942159468 scopus 로고    scopus 로고
    • EGFR mutations and resistance to irreversible pyrimidine-based EGFR inhibitors
    • 84 Ercan, D, Choi, HG, Yun, CH, et al. EGFR mutations and resistance to irreversible pyrimidine-based EGFR inhibitors. Clin Cancer Res 21 (2015), 3913–3923.
    • (2015) Clin Cancer Res , vol.21 , pp. 3913-3923
    • Ercan, D.1    Choi, H.G.2    Yun, C.H.3
  • 85
    • 84938399710 scopus 로고    scopus 로고
    • Detection and dynamic changes of EGFR mutations from circulating tumor DNA as a predictor of survival outcomes in NSCLC patients treated with first-line intercalated erlotinib and chemotherapy
    • 85 Mok, T, Wu, Y-L, Lee, JS, et al. Detection and dynamic changes of EGFR mutations from circulating tumor DNA as a predictor of survival outcomes in NSCLC patients treated with first-line intercalated erlotinib and chemotherapy. Clin Cancer Res 21 (2015), 3196–3203.
    • (2015) Clin Cancer Res , vol.21 , pp. 3196-3203
    • Mok, T.1    Wu, Y.-L.2    Lee, J.S.3
  • 86
    • 84896539307 scopus 로고    scopus 로고
    • Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA
    • 86 Oxnard, GR, Paweletz, CP, Kuang, Y, et al. Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA. Clin Cancer Res 20 (2014), 1698–1705.
    • (2014) Clin Cancer Res , vol.20 , pp. 1698-1705
    • Oxnard, G.R.1    Paweletz, C.P.2    Kuang, Y.3
  • 87
    • 84965092386 scopus 로고    scopus 로고
    • Association of EGFR L858R mutation in circulating free DNA with survival in the EURTAC trial
    • 87 Karachaliou, N, Mayo-de las Casas, C, Queralt, C, et al. Association of EGFR L858R mutation in circulating free DNA with survival in the EURTAC trial. JAMA Oncol 1 (2015), 149–157.
    • (2015) JAMA Oncol , vol.1 , pp. 149-157
    • Karachaliou, N.1    Mayo-de las Casas, C.2    Queralt, C.3
  • 88
    • 84879784343 scopus 로고    scopus 로고
    • Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial
    • 88 Wu, Y-L, Lee, JS, Thongprasert, S, et al. Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial. Lancet Oncol 14 (2013), 777–786.
    • (2013) Lancet Oncol , vol.14 , pp. 777-786
    • Wu, Y.-L.1    Lee, J.S.2    Thongprasert, S.3
  • 89
    • 84908127948 scopus 로고    scopus 로고
    • Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study
    • 89 Seto, T, Kato, T, Nishio, M, et al. Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study. Lancet Oncol 15 (2014), 1236–1244.
    • (2014) Lancet Oncol , vol.15 , pp. 1236-1244
    • Seto, T.1    Kato, T.2    Nishio, M.3
  • 90
    • 84969833645 scopus 로고    scopus 로고
    • A phase II trial of erlotinib (E) and bevacizumab (B) in patients with advanced non-small-cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) mutations with and without T790M mutation. The Spanish Lung Cancer Group (SLCG) and the European Thoracic Oncology Platform (ETOP) BELIEF trial
    • 90 Stahel, RA, Dafni, U, Gautschi, O, et al. A phase II trial of erlotinib (E) and bevacizumab (B) in patients with advanced non-small-cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) mutations with and without T790M mutation. The Spanish Lung Cancer Group (SLCG) and the European Thoracic Oncology Platform (ETOP) BELIEF trial. Eur J Cancer 51 (2015), S711–S712.
    • (2015) Eur J Cancer , vol.51 , pp. S711-S712
    • Stahel, R.A.1    Dafni, U.2    Gautschi, O.3
  • 91
    • 84945325367 scopus 로고    scopus 로고
    • Discovery and evaluation of clinical candidate AZD3759, a potent, oral active, central nervous system-penetrant, epidermal growth factor receptor tyrosine kinase inhibitor
    • 91 Zeng, Q, Wang, J, Cheng, Z, et al. Discovery and evaluation of clinical candidate AZD3759, a potent, oral active, central nervous system-penetrant, epidermal growth factor receptor tyrosine kinase inhibitor. J Med Chem 58 (2015), 8200–8215.
    • (2015) J Med Chem , vol.58 , pp. 8200-8215
    • Zeng, Q.1    Wang, J.2    Cheng, Z.3
  • 92
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • 92 Soda, M, Choi, YL, Enomoto, M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448 (2007), 561–566.
    • (2007) Nature , vol.448 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3
  • 93
    • 36849065315 scopus 로고    scopus 로고
    • Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
    • 93 Rikova, K, Guo, A, Zeng, Q, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131 (2007), 1190–1203.
    • (2007) Cell , vol.131 , pp. 1190-1203
    • Rikova, K.1    Guo, A.2    Zeng, Q.3
  • 94
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • 94 Kwak, EL, Bang, YJ, Camidge, DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 363 (2010), 1693–1703.
    • (2010) N Engl J Med , vol.363 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 95
    • 84866934606 scopus 로고    scopus 로고
    • Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study
    • 95 Camidge, DR, Bang, YJ, Kwak, EL, et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol 13 (2012), 1011–1019.
    • (2012) Lancet Oncol , vol.13 , pp. 1011-1019
    • Camidge, D.R.1    Bang, Y.J.2    Kwak, E.L.3
  • 96
    • 84865431278 scopus 로고    scopus 로고
    • Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer
    • (abstr).
    • 96 Kim, D-W, Ahn, M-J, Shi, Y, et al. Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer. J Clin Oncol, 30, 2012, 7533 (abstr).
    • (2012) J Clin Oncol , vol.30 , pp. 7533
    • Kim, D.-W.1    Ahn, M.-J.2    Shi, Y.3
  • 97
    • 84929508050 scopus 로고    scopus 로고
    • Clinical experience with crizotinib in patients with advanced ALK-rearranged nonsmall-cell lung cancer and brain metastases
    • 97 Costa, DB, Shaw, AT, Ou, SH, et al. Clinical experience with crizotinib in patients with advanced ALK-rearranged nonsmall-cell lung cancer and brain metastases. J Clin Oncol 33 (2015), 1881–1888.
    • (2015) J Clin Oncol , vol.33 , pp. 1881-1888
    • Costa, D.B.1    Shaw, A.T.2    Ou, S.H.3
  • 98
    • 84856990335 scopus 로고    scopus 로고
    • Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
    • 98 Doebele, RC, Pilling, AB, Aisner, DL, et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res 18 (2012), 1472–1482.
    • (2012) Clin Cancer Res , vol.18 , pp. 1472-1482
    • Doebele, R.C.1    Pilling, A.B.2    Aisner, D.L.3
  • 99
    • 84903466222 scopus 로고    scopus 로고
    • The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer
    • 99 Friboulet, L, Li, N, Katayama, R, et al. The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer. Cancer Discov 4 (2014), 662–673.
    • (2014) Cancer Discov , vol.4 , pp. 662-673
    • Friboulet, L.1    Li, N.2    Katayama, R.3
  • 100
    • 84941674243 scopus 로고    scopus 로고
    • ASCEND-2: A single-arm, open-label, multicenter phase II study of ceritinib in adult patients (pts) with ALK-rearranged (ALK+) non-small cell lung cancer (NSCLC) previously treated with chemotherapy and crizotinib (CRZ)
    • (abstr).
    • 100 Mok, T, Spigel, D, Felip, E, et al. ASCEND-2: A single-arm, open-label, multicenter phase II study of ceritinib in adult patients (pts) with ALK-rearranged (ALK+) non-small cell lung cancer (NSCLC) previously treated with chemotherapy and crizotinib (CRZ). J Clin Oncol, 33, 2015, 8059 (abstr).
    • (2015) J Clin Oncol , vol.33 , pp. 8059
    • Mok, T.1    Spigel, D.2    Felip, E.3
  • 101
    • 84959324643 scopus 로고    scopus 로고
    • Alectinib in ALK-positive, crizotinib-resistant, non-small-cell lung cancer: a single-group, multicentre, phase 2 trial
    • 101 Shaw, AT, Gandhi, L, Gadgeel, S, et al. Alectinib in ALK-positive, crizotinib-resistant, non-small-cell lung cancer: a single-group, multicentre, phase 2 trial. Lancet Oncol 17 (2016), 234–242.
    • (2016) Lancet Oncol , vol.17 , pp. 234-242
    • Shaw, A.T.1    Gandhi, L.2    Gadgeel, S.3
  • 102
    • 84941630750 scopus 로고    scopus 로고
    • ASCEND-3: A single-arm, open-label, multicenter phase II study of ceritinib in ALKi-naïve adult patients (pts) with ALK-rearranged (ALK+) non-small cell lung cancer (NSCLC)
    • (abstr).
    • 102 Felip, E, Orlov, S, Park, K, et al. ASCEND-3: A single-arm, open-label, multicenter phase II study of ceritinib in ALKi-naïve adult patients (pts) with ALK-rearranged (ALK+) non-small cell lung cancer (NSCLC). J Clin Oncol, 33, 2015, 8060 (abstr).
    • (2015) J Clin Oncol , vol.33 , pp. 8060
    • Felip, E.1    Orlov, S.2    Park, K.3
  • 103
    • 84878347085 scopus 로고    scopus 로고
    • CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1-2 study
    • 103 Seto, T, Kiura, K, Nishio, M, et al. CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1-2 study. Lancet Oncol 14 (2013), 590–598.
    • (2013) Lancet Oncol , vol.14 , pp. 590-598
    • Seto, T.1    Kiura, K.2    Nishio, M.3
  • 104
    • 84978614669 scopus 로고    scopus 로고
    • Alectinib (ALC) versus crizotinib (CRZ) in ALK-inhibitor naive ALK-positive non-small cell lung cancer (ALK+ NSCLC): Primary results from the J-ALEX study
    • (abstr).
    • 104 Nokihara, H, Hida, T, Kondo, M, et al. Alectinib (ALC) versus crizotinib (CRZ) in ALK-inhibitor naive ALK-positive non-small cell lung cancer (ALK+ NSCLC): Primary results from the J-ALEX study. J Clin Oncol, 34, 2016, 9008 (abstr).
    • (2016) J Clin Oncol , vol.34 , pp. 9008
    • Nokihara, H.1    Hida, T.2    Kondo, M.3
  • 105
    • 84870748688 scopus 로고    scopus 로고
    • RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer
    • 105 Wang, R, Hu, H, Pan, Y, et al. RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. J Clin Oncol 30 (2012), 4352–4359.
    • (2012) J Clin Oncol , vol.30 , pp. 4352-4359
    • Wang, R.1    Hu, H.2    Pan, Y.3
  • 106
    • 84959320806 scopus 로고    scopus 로고
    • Clinicopathological characteristics of RET rearranged lung cancer in European patients
    • 106 Michels, S, Scheel, AH, Scheffler, M, et al. Clinicopathological characteristics of RET rearranged lung cancer in European patients. J Thorac Oncol 11 (2016), 122–127.
    • (2016) J Thorac Oncol , vol.11 , pp. 122-127
    • Michels, S.1    Scheel, A.H.2    Scheffler, M.3
  • 107
    • 84940394869 scopus 로고    scopus 로고
    • Phase III multinational, randomized, double-blind, placebo-controlled study of tivantinib (ARQ 197) plus erlotinib versus erlotinib alone in previously treated patients with locally advanced or metastatic nonsquamous non-small-cell lung cancer
    • 107 Scagliotti, G, von Pawel, J, Novello, S, et al. Phase III multinational, randomized, double-blind, placebo-controlled study of tivantinib (ARQ 197) plus erlotinib versus erlotinib alone in previously treated patients with locally advanced or metastatic nonsquamous non-small-cell lung cancer. J Clin Oncol 33 (2015), 2667–2674.
    • (2015) J Clin Oncol , vol.33 , pp. 2667-2674
    • Scagliotti, G.1    von Pawel, J.2    Novello, S.3
  • 108
    • 84904679830 scopus 로고    scopus 로고
    • Onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIb or IV NSCLC: Results from the pivotal phase III randomized, multicentre, placebo-controlled METLung (OAM4971g) global trial
    • (abstr).
    • 108 Spigel, DR, Edelman, MJ, O'Byrne, K, et al. Onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIb or IV NSCLC: Results from the pivotal phase III randomized, multicentre, placebo-controlled METLung (OAM4971g) global trial. J Clin Oncol, 32, 2014, 8000 (abstr).
    • (2014) J Clin Oncol , vol.32 , pp. 8000
    • Spigel, D.R.1    Edelman, M.J.2    O'Byrne, K.3
  • 109
    • 84942524970 scopus 로고    scopus 로고
    • Interim results of a phase II study of the BRAF inhibitor (BRAFi) dabrafenib (D) in combination with the MEK inhibitor trametinib (T) in patients (pts) with BRAFV600E mutated (mut) metastatic non-small cell lung cancer (NSCLC)
    • (abstr).
    • 109 Planchard, D, Groen, HJM, Kim, TM, et al. Interim results of a phase II study of the BRAF inhibitor (BRAFi) dabrafenib (D) in combination with the MEK inhibitor trametinib (T) in patients (pts) with BRAFV600E mutated (mut) metastatic non-small cell lung cancer (NSCLC). J Clin Oncol, 33, 2015, 8006 (abstr).
    • (2015) J Clin Oncol , vol.33 , pp. 8006
    • Planchard, D.1    Groen, H.J.M.2    Kim, T.M.3
  • 110
    • 84883347910 scopus 로고    scopus 로고
    • Mutation incidence and coincidence in non small-cell lung cancer: meta-analyses by ethnicity and histology (mutMap)
    • 110 Dearden, S, Stevens, J, Wu, Y-L, Blowers, D, Mutation incidence and coincidence in non small-cell lung cancer: meta-analyses by ethnicity and histology (mutMap). Ann Oncol 24 (2013), 2371–2376.
    • (2013) Ann Oncol , vol.24 , pp. 2371-2376
    • Dearden, S.1    Stevens, J.2    Wu, Y.-L.3    Blowers, D.4
  • 111
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • 111 Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature 489 (2012), 519–525.
    • (2012) Nature , vol.489 , pp. 519-525
  • 112
    • 78650451788 scopus 로고    scopus 로고
    • Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
    • 112 Weiss, J, Sos, ML, Seidel, D, et al. Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci Transl Med, 2, 2010, 62ra93.
    • (2010) Sci Transl Med , vol.2 , pp. 62ra93
    • Weiss, J.1    Sos, M.L.2    Seidel, D.3
  • 113
    • 84866709500 scopus 로고    scopus 로고
    • Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
    • 113 Hammerman, PS, Sos, ML, Ramos, AH, et al. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov 1 (2011), 78–89.
    • (2011) Cancer Discov , vol.1 , pp. 78-89
    • Hammerman, P.S.1    Sos, M.L.2    Ramos, A.H.3
  • 114
    • 84962812153 scopus 로고    scopus 로고
    • Small cell lung cancer: can recent advances in biology and molecular biology be translated into improved outcomes?
    • 114 Bunn, PA Jr, Minna, J, Augustyn, A, et al. Small cell lung cancer: can recent advances in biology and molecular biology be translated into improved outcomes?. J Thorac Oncol 4 (2016), 453–474.
    • (2016) J Thorac Oncol , vol.4 , pp. 453-474
    • Bunn, P.A.1    Minna, J.2    Augustyn, A.3
  • 115
    • 84941986957 scopus 로고    scopus 로고
    • Small cell lung cancer: will recent progress lead to improved outcomes?
    • 115 Pietanza, MC, Byers, LA, Minna, JD, Small cell lung cancer: will recent progress lead to improved outcomes?. Clin Cancer Res 21 (2015), 2244–2255.
    • (2015) Clin Cancer Res , vol.21 , pp. 2244-2255
    • Pietanza, M.C.1    Byers, L.A.2    Minna, J.D.3
  • 116
    • 84958243096 scopus 로고    scopus 로고
    • Multimodality therapy for limited-stage small-cell lung cancer
    • 116 Almquist, D, Mosalpuria, K, Ganti, AK, Multimodality therapy for limited-stage small-cell lung cancer. J Oncol Pract 12 (2016), 111–117.
    • (2016) J Oncol Pract , vol.12 , pp. 111-117
    • Almquist, D.1    Mosalpuria, K.2    Ganti, A.K.3
  • 117
    • 84906903314 scopus 로고    scopus 로고
    • Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial
    • 117 Garon, EB, Ciuleanu, TE, Arrieta, O, et al. Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial. Lancet 384 (2014), 665–673.
    • (2014) Lancet , vol.384 , pp. 665-673
    • Garon, E.B.1    Ciuleanu, T.E.2    Arrieta, O.3
  • 118
    • 84892967581 scopus 로고    scopus 로고
    • Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial
    • 118 Reck, M, Kaiser, R, Mellemgaard, A, et al., LUME-Lung 1 Study Group. Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial. Lancet Oncol 15 (2014), 143–155.
    • (2014) Lancet Oncol , vol.15 , pp. 143-155
    • Reck, M.1    Kaiser, R.2    Mellemgaard, A.3
  • 119
    • 84986876119 scopus 로고    scopus 로고
    • European Medicines Agency Dec 17, London Dec 17, (accessed March 6, 2016). Dec 17
    • 119 Committee for Medicinal Products for Human Use. Summary of opinion: Portrazza, Dec 17, 2015, European Medicines Agency, London http://www.ema.europa.eu/docs/en_GB/document_library/Summary_of_opinion_-_Initial_authorisation/human/003886/WC500199044.pdf (accessed March 6, 2016).
    • (2015) Summary of opinion: Portrazza
  • 120
    • 84895812969 scopus 로고    scopus 로고
    • New strategies in lung cancer: translating immunotherapy into clinical practice
    • 120 Forde, PM, Kelly, RJ, Brahmer, JR, New strategies in lung cancer: translating immunotherapy into clinical practice. Clin Cancer Res 20 (2014), 1067–1073.
    • (2014) Clin Cancer Res , vol.20 , pp. 1067-1073
    • Forde, P.M.1    Kelly, R.J.2    Brahmer, J.R.3
  • 121
    • 84964637785 scopus 로고    scopus 로고
    • Efficacy of the MAGE-A3 cancer immunotherapeutic as adjuvant therapy in patients with resected MAGE-A3-positive non-small-cell lung cancer (MAGRIT): a randomised, double-blind, placebo-controlled, phase 3 trial
    • 121 Vansteenkiste, JF, Cho, BC, Vanakesa, T, et al. Efficacy of the MAGE-A3 cancer immunotherapeutic as adjuvant therapy in patients with resected MAGE-A3-positive non-small-cell lung cancer (MAGRIT): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 17 (2016), 822–835.
    • (2016) Lancet , vol.17 , pp. 822-835
    • Vansteenkiste, J.F.1    Cho, B.C.2    Vanakesa, T.3
  • 122
    • 84959273798 scopus 로고    scopus 로고
    • TG4010 immunotherapy and first-line chemotherapy for advanced non-small-cell lung cancer (TIME): results from the phase 2b part of a randomised, double-blind, placebo-controlled, phase 2b/3 trial
    • 122 Quoix, E, Lena, H, Losonczy, G, et al. TG4010 immunotherapy and first-line chemotherapy for advanced non-small-cell lung cancer (TIME): results from the phase 2b part of a randomised, double-blind, placebo-controlled, phase 2b/3 trial. Lancet Oncol 17 (2016), 212–223.
    • (2016) Lancet Oncol , vol.17 , pp. 212-223
    • Quoix, E.1    Lena, H.2    Losonczy, G.3
  • 123
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • 123 Pardoll, DM, The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 12 (2012), 252–264.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 124
    • 84927150740 scopus 로고    scopus 로고
    • Immune checkpoint blockade in cancer therapy
    • 124 Postow, M, Callahan, MK, Woldchok, JD, Immune checkpoint blockade in cancer therapy. J Clin Oncol 33 (2015), 1974–1983.
    • (2015) J Clin Oncol , vol.33 , pp. 1974-1983
    • Postow, M.1    Callahan, M.K.2    Woldchok, J.D.3
  • 125
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
    • 125 Brahmer, J, Reckamp, KL, Baas, P, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med 373 (2015), 123–135.
    • (2015) N Engl J Med , vol.373 , pp. 123-135
    • Brahmer, J.1    Reckamp, K.L.2    Baas, P.3
  • 126
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
    • 126 Borghaei, H, Paz-Ares, L, Horn, L, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med 373 (2015), 1627–1639.
    • (2015) N Engl J Med , vol.373 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3
  • 127
    • 84950117835 scopus 로고    scopus 로고
    • Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
    • 127 Herbst, R, Baas, P, Kim, DW, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 387 (2015), 1540–1550.
    • (2015) Lancet , vol.387 , pp. 1540-1550
    • Herbst, R.1    Baas, P.2    Kim, D.W.3
  • 128
    • 84962038946 scopus 로고    scopus 로고
    • Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial
    • 128 Fehrenbacher, L, Spira, A, Ballinger, M, et al. Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial. Lancet 387 (2016), 1837–1846.
    • (2016) Lancet , vol.387 , pp. 1837-1846
    • Fehrenbacher, L.1    Spira, A.2    Ballinger, M.3
  • 129
    • 84944734156 scopus 로고    scopus 로고
    • Safety and clinical activity of MEDI4736, an anti-programmed cell death-ligand 1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC)
    • (abstr).
    • 129 Rizvi, N, Brahmer, JR, Ou, SH, et al. Safety and clinical activity of MEDI4736, an anti-programmed cell death-ligand 1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC). J Clin Oncol, 33, 2015, 8032 (abstr).
    • (2015) J Clin Oncol , vol.33 , pp. 8032
    • Rizvi, N.1    Brahmer, J.R.2    Ou, S.H.3
  • 130
    • 84944751040 scopus 로고    scopus 로고
    • Avelumab (MSB0010718C), an anti-PD-L1 antibody, in advanced NSCLC patients: a phase 1b, open-label expansion trial in patients progressing after platinum-based chemotherapy
    • (abstr).
    • 130 Gulley, JL, Spigel, D, Chandler, JC, et al. Avelumab (MSB0010718C), an anti-PD-L1 antibody, in advanced NSCLC patients: a phase 1b, open-label expansion trial in patients progressing after platinum-based chemotherapy. J Clin Oncol, 33, 2015, 8034 (abstr).
    • (2015) J Clin Oncol , vol.33 , pp. 8034
    • Gulley, J.L.1    Spigel, D.2    Chandler, J.C.3
  • 131
    • 84936749833 scopus 로고    scopus 로고
    • Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer
    • 131 Gettinger, SN, Horn, L, Gandhi, L, et al. Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol 33 (2015), 2004–2012.
    • (2015) J Clin Oncol , vol.33 , pp. 2004-2012
    • Gettinger, S.N.1    Horn, L.2    Gandhi, L.3
  • 132
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • 132 Garon, EB, Rizvi, NA, Hui, R, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 372 (2015), 2018–2028.
    • (2015) N Engl J Med , vol.372 , pp. 2018-2028
    • Garon, E.B.1    Rizvi, N.A.2    Hui, R.3
  • 133
    • 85031651624 scopus 로고    scopus 로고
    • Efficacy and safety of pembrolizumab (Pembro; MK-3475) for patients (pts) with previously treated advanced non-small cell lung cancer (NSCLC) enrolled in KEYNOTE-001
    • (abstr).
    • 133 Soria, JC, Fløtten, Ø, Horn, L, et al. Efficacy and safety of pembrolizumab (Pembro; MK-3475) for patients (pts) with previously treated advanced non-small cell lung cancer (NSCLC) enrolled in KEYNOTE-001. Ann Oncol, 26, 2015, 33LBA (abstr).
    • (2015) Ann Oncol , vol.26 , pp. 33LBA
    • Soria, J.C.1    Fløtten, Ø.2    Horn, L.3
  • 134
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • 134 Herbst, RS, Soria, JC, Kowanetz, M, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 515 (2014), 563–567.
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1    Soria, J.C.2    Kowanetz, M.3
  • 136
    • 84964031961 scopus 로고    scopus 로고
    • Programmed Death Ligand 1 immunohistochemistry: friend or foe?
    • 136 Kerr, KM, Hirsch, FR, Programmed Death Ligand 1 immunohistochemistry: friend or foe?. Arch Pathol Lab Med 140 (2016), 326–331.
    • (2016) Arch Pathol Lab Med , vol.140 , pp. 326-331
    • Kerr, K.M.1    Hirsch, F.R.2
  • 137
    • 85009840975 scopus 로고    scopus 로고
    • Phase II, single-arm trial (BIRCH) of atezolizumab as first-line or subsequent therapy for locally advanced or metastatic PD-L1-selected non-small cell lung cancer (NSCLC)
    • 137 Besse, B, Johnson, M, Janne, PA, et al. Phase II, single-arm trial (BIRCH) of atezolizumab as first-line or subsequent therapy for locally advanced or metastatic PD-L1-selected non-small cell lung cancer (NSCLC). Eur J Cancer 51 (2015), S717–S718.
    • (2015) Eur J Cancer , vol.51 , pp. S717-S718
    • Besse, B.1    Johnson, M.2    Janne, P.A.3
  • 138
    • 84939518267 scopus 로고    scopus 로고
    • Phase I/II study of nivolumab with or without ipilimumab for the treatment of recurrent small cell lung cancer (SCLC): CA209.032
    • (abstr).
    • 138 Antonia, SJ, Bendel, JC, Taylor, MH, et al. Phase I/II study of nivolumab with or without ipilimumab for the treatment of recurrent small cell lung cancer (SCLC): CA209.032. J Clin Oncol, 33, 2015, 7503 (abstr).
    • (2015) J Clin Oncol , vol.33 , pp. 7503
    • Antonia, S.J.1    Bendel, J.C.2    Taylor, M.H.3
  • 139
    • 85009836308 scopus 로고    scopus 로고
    • Single-agent pembrolizumab for patients with malignant pleural mesothelioma (MPM). IASLC 16th World Conference on Lung Cancer; Denver, CO, USA; Sept 6–9, 2015. Abstract 3011.
    • 139 Alley EW, Schellens JH, Santoro A, et al. Single-agent pembrolizumab for patients with malignant pleural mesothelioma (MPM). IASLC 16th World Conference on Lung Cancer; Denver, CO, USA; Sept 6–9, 2015. Abstract 3011.
    • Alley, E.W.1    Schellens, J.H.2    Santoro, A.3
  • 140
    • 79955006086 scopus 로고    scopus 로고
    • Lung cancer: new biological insights and recent therapeutic advances
    • 140 Ramalingam, SS, Owonikoko, TK, Khuri, FR, Lung cancer: new biological insights and recent therapeutic advances. CA Cancer J Clin 61 (2011), 91–112.
    • (2011) CA Cancer J Clin , vol.61 , pp. 91-112
    • Ramalingam, S.S.1    Owonikoko, T.K.2    Khuri, F.R.3
  • 141
    • 84945194223 scopus 로고    scopus 로고
    • Systemic therapy for stage iv non-small-cell lung cancer: American Society of Clinical Oncology Clinical Practice Guideline Update
    • 141 Masters, GA, Temin, S, Azzoli, CG, et al. Systemic therapy for stage iv non-small-cell lung cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol 33 (2015), 3488–3515.
    • (2015) J Clin Oncol , vol.33 , pp. 3488-3515
    • Masters, G.A.1    Temin, S.2    Azzoli, C.G.3
  • 142
    • 70350225538 scopus 로고    scopus 로고
    • Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study
    • 142 Ciuleanu, T, Brodowicz, T, Zielinski, C, et al. Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study. Lancet 374 (2009), 1432–1440.
    • (2009) Lancet , vol.374 , pp. 1432-1440
    • Ciuleanu, T.1    Brodowicz, T.2    Zielinski, C.3
  • 143
    • 77953541527 scopus 로고    scopus 로고
    • Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study
    • 143 Cappuzzo, F, Ciuleanu, T, Stelmakh, L, et al. Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol 11 (2010), 521–529.
    • (2010) Lancet Oncol , vol.11 , pp. 521-529
    • Cappuzzo, F.1    Ciuleanu, T.2    Stelmakh, L.3
  • 144
    • 84885924300 scopus 로고    scopus 로고
    • PARAMOUNT: final overall survival results of the phase III study of maintenance pemetrexed versus placebo immediately after induction treatment with pemetrexed plus cisplatin for advanced non-squamous non-small-cell lung cancer
    • 144 Paz-Ares, LG, de Marinis, F, Dediu, M, et al. PARAMOUNT: final overall survival results of the phase III study of maintenance pemetrexed versus placebo immediately after induction treatment with pemetrexed plus cisplatin for advanced non-squamous non-small-cell lung cancer. J Clin Oncol 31 (2013), 2895–2902.
    • (2013) J Clin Oncol , vol.31 , pp. 2895-2902
    • Paz-Ares, L.G.1    de Marinis, F.2    Dediu, M.3
  • 145
    • 15944388587 scopus 로고    scopus 로고
    • Randomized study of maintenance vinorelbine in responders with advanced non-small-cell lung cancer
    • 145 Westeel, V, Quoix, E, Moro-Sibilot, D, et al. Randomized study of maintenance vinorelbine in responders with advanced non-small-cell lung cancer. J Natl Cancer Inst 97 (2005), 499–506.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 499-506
    • Westeel, V.1    Quoix, E.2    Moro-Sibilot, D.3
  • 146
    • 59149092945 scopus 로고    scopus 로고
    • Phase III study of immediate compared with delayed docetaxel after front-line therapy with gemcitabine plus carboplatin in advanced non-small-cell lung cancer
    • 146 Fidias, PM, Dakhil, SR, Lyss, AP, et al. Phase III study of immediate compared with delayed docetaxel after front-line therapy with gemcitabine plus carboplatin in advanced non-small-cell lung cancer. J Clin Oncol 27 (2009), 591–598.
    • (2009) J Clin Oncol , vol.27 , pp. 591-598
    • Fidias, P.M.1    Dakhil, S.R.2    Lyss, A.P.3
  • 147
    • 33646485007 scopus 로고    scopus 로고
    • Cisplatin and gemcitabine first-line chemotherapy followed by maintenance gemcitabine or best supportive care in advanced non-small cell lung cancer: a phase III trial
    • 147 Brodowicz, T, Krzakowski, M, Zwitter, M, et al. Cisplatin and gemcitabine first-line chemotherapy followed by maintenance gemcitabine or best supportive care in advanced non-small cell lung cancer: a phase III trial. Lung Cancer 52 (2006), 155–163.
    • (2006) Lung Cancer , vol.52 , pp. 155-163
    • Brodowicz, T.1    Krzakowski, M.2    Zwitter, M.3
  • 148
    • 78049401119 scopus 로고    scopus 로고
    • Randomized trial of gemcitabine-carboplatin (G-Cb) therapy followed by gemcitabine (G) maintenance or best supportive care (BSC) in advanced NSCLC
    • (abstr).
    • 148 Belani, CP, Waterhouse, DM, Ghazal, HH, et al. Randomized trial of gemcitabine-carboplatin (G-Cb) therapy followed by gemcitabine (G) maintenance or best supportive care (BSC) in advanced NSCLC. J Clin Oncol, 28, 2010, 7506 (abstr).
    • (2010) J Clin Oncol , vol.28 , pp. 7506
    • Belani, C.P.1    Waterhouse, D.M.2    Ghazal, H.H.3
  • 149
    • 84867059528 scopus 로고    scopus 로고
    • Randomized, phase III study of gemcitabine or erlotinib maintenance therapy versus observation, with predefined second-line treatment, after cisplatin-gemcitabine induction chemotherapy in advanced non-small-cell lung cancer
    • 149 Perol, M, Chouaid, C, Perol, D, et al. Randomized, phase III study of gemcitabine or erlotinib maintenance therapy versus observation, with predefined second-line treatment, after cisplatin-gemcitabine induction chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 30 (2012), 3516–3524.
    • (2012) J Clin Oncol , vol.30 , pp. 3516-3524
    • Perol, M.1    Chouaid, C.2    Perol, D.3
  • 150
    • 79960414995 scopus 로고    scopus 로고
    • Maintenance therapy with continuous or switch strategy in advanced non-small cell lung cancer: a systematic review and meta-analysis
    • 150 Zhang, X, Zang, J, Xu, J, et al. Maintenance therapy with continuous or switch strategy in advanced non-small cell lung cancer: a systematic review and meta-analysis. Chest 140 (2011), 117–126.
    • (2011) Chest , vol.140 , pp. 117-126
    • Zhang, X.1    Zang, J.2    Xu, J.3
  • 151
    • 84863785946 scopus 로고    scopus 로고
    • Single agent maintenance therapy for advanced stage non-small cell lung cancer: a meta-analysis
    • 151 Behera, M, Owonikoko, TK, Chen, Z, et al. Single agent maintenance therapy for advanced stage non-small cell lung cancer: a meta-analysis. Lung Cancer 77 (2012), 331–338.
    • (2012) Lung Cancer , vol.77 , pp. 331-338
    • Behera, M.1    Owonikoko, T.K.2    Chen, Z.3
  • 152
    • 84930934298 scopus 로고    scopus 로고
    • Final overall survival results from a phase III, randomized, placebo-controlled, parallel-group study of gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804)
    • 152 Zhao, H, Fan, Y, Ma, S, et al. Final overall survival results from a phase III, randomized, placebo-controlled, parallel-group study of gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804). J Thorac Oncol 10 (2015), 655–664.
    • (2015) J Thorac Oncol , vol.10 , pp. 655-664
    • Zhao, H.1    Fan, Y.2    Ma, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.