-
1
-
-
0037603589
-
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
-
Abifadel M, Varret M, Rabès JP, Allard D, Ouguerram K, Devillers M, Cruaud C, Benjannet S, Wickham L, Erlich D et al (2003) Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet 34: 154–156
-
(2003)
Nat Genet
, vol.34
, pp. 154-156
-
-
Abifadel, M.1
Varret, M.2
Rabès, J.P.3
Allard, D.4
Ouguerram, K.5
Devillers, M.6
Cruaud, C.7
Benjannet, S.8
Wickham, L.9
Erlich, D.10
-
2
-
-
0842299577
-
Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment
-
Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S, Hobbs AJ (2004) Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. Proc Natl Acad Sci USA 101: 1386–1391
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 1386-1391
-
-
Ahluwalia, A.1
Foster, P.2
Scotland, R.S.3
McLean, P.G.4
Mathur, A.5
Perretti, M.6
Moncada, S.7
Hobbs, A.J.8
-
3
-
-
84927578440
-
Results of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, from a randomized, placebo-controlled, dose-ranging study in statin-treated subjects with hypercholesterolemia
-
Ballantyne CM, Neutel J, Cropp A, Duggan W, Wang EQ, Plowchalk D, Sweeney K, Kaila N, Vincent J, Bays H (2015) Results of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, from a randomized, placebo-controlled, dose-ranging study in statin-treated subjects with hypercholesterolemia. Am J Cardiol 115: 1212–1221
-
(2015)
Am J Cardiol
, vol.115
, pp. 1212-1221
-
-
Ballantyne, C.M.1
Neutel, J.2
Cropp, A.3
Duggan, W.4
Wang, E.Q.5
Plowchalk, D.6
Sweeney, K.7
Kaila, N.8
Vincent, J.9
Bays, H.10
-
4
-
-
67349199566
-
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
-
Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C et al (2009) Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 41: 703–707
-
(2009)
Nat Genet
, vol.41
, pp. 703-707
-
-
Barrett, J.C.1
Clayton, D.G.2
Concannon, P.3
Akolkar, B.4
Cooper, J.D.5
Erlich, H.A.6
Julier, C.7
Morahan, G.8
Nerup, J.9
Nierras, C.10
-
5
-
-
84941940944
-
Using human genetics to make new medicines
-
Barrett JC, Dunham I, Birney E (2015) Using human genetics to make new medicines. Nat Rev Genet 16: 561–562
-
(2015)
Nat Rev Genet
, vol.16
, pp. 561-562
-
-
Barrett, J.C.1
Dunham, I.2
Birney, E.3
-
6
-
-
84929359490
-
Knockout of adamts7, a novel CAD locus in humans, reduces atherosclerosis in mice
-
Bauer RC, Tohyama J, Cui J, Cheng L, Yang J, Zhang X, Ou K, Paschos GK, Zheng XL, Parmacek MS et al (2015) Knockout of adamts7, a novel CAD locus in humans, reduces atherosclerosis in mice. Circulation 131: 1202–1213
-
(2015)
Circulation
, vol.131
, pp. 1202-1213
-
-
Bauer, R.C.1
Tohyama, J.2
Cui, J.3
Cheng, L.4
Yang, J.5
Zhang, X.6
Ou, K.7
Paschos, G.K.8
Zheng, X.L.9
Parmacek, M.S.10
-
7
-
-
84923342405
-
Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders
-
Bjoerkegren JL, Kovacic JC, Dudley JT, Schadt EE (2015) Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders. J Am Coll Cardiol 65: 830–845
-
(2015)
J Am Coll Cardiol
, vol.65
, pp. 830-845
-
-
Bjoerkegren, J.L.1
Kovacic, J.C.2
Dudley, J.T.3
Schadt, E.E.4
-
8
-
-
84942242979
-
Prediction of causal candidate genes in coronary artery disease loci
-
Braenne I, Civelek M, Vilne B, Di Narzo A, Johnson AD, Zhao Y, Reiz B, Codoni V, Webb TR, Foroughi Asl H et al (2015) Prediction of causal candidate genes in coronary artery disease loci. Arterioscler Thromb Vasc Biol 35: 2207–2217
-
(2015)
Arterioscler Thromb Vasc Biol
, vol.35
, pp. 2207-2217
-
-
Braenne, I.1
Civelek, M.2
Vilne, B.3
Di Narzo, A.4
Johnson, A.D.5
Zhao, Y.6
Reiz, B.7
Codoni, V.8
Webb, T.R.9
Foroughi Asl, H.10
-
9
-
-
79955481506
-
Pharmacological strategies for lowering LDL cholesterol: statins and beyond
-
Brautbar A, Ballantyne CM (2011) Pharmacological strategies for lowering LDL cholesterol: statins and beyond. Nat Rev Cardiol 8: 253–265
-
(2011)
Nat Rev Cardiol
, vol.8
, pp. 253-265
-
-
Brautbar, A.1
Ballantyne, C.M.2
-
10
-
-
79951990503
-
Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data
-
C Reactive Protein Coronary Heart Disease Genetics Collaboration C (2011) Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. BMJ 342: d548
-
(2011)
BMJ
, vol.342
, pp. 548
-
-
C Reactive Protein Coronary Heart Disease Genetics Collaboration, C.1
-
11
-
-
58349111875
-
AmiGO: online access to ontology and annotation data
-
Carbon S, Ireland A, Mungall CJ, Shu S, Marshall B, Lewis S, AmiGO Hub, Web Presence Working Group (2009) AmiGO: online access to ontology and annotation data. Bioinformatics 25: 288–289
-
(2009)
Bioinformatics
, vol.25
, pp. 288-289
-
-
Carbon, S.1
Ireland, A.2
Mungall, C.J.3
Shu, S.4
Marshall, B.5
Lewis, S.6
-
12
-
-
84871969762
-
Large-scale association analysis identifies new risk loci for coronary artery disease
-
CARDIoGRAMplusC4D Consortium (2013) Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 45: 25–33
-
(2013)
Nat Genet
, vol.45
, pp. 25-33
-
-
-
13
-
-
33645103550
-
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
-
Cohen JC, Boerwinkle E, Mosley TH, Hobbs HH (2006) Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 354: 1264–1272
-
(2006)
N Engl J Med
, vol.354
, pp. 1264-1272
-
-
Cohen, J.C.1
Boerwinkle, E.2
Mosley, T.H.3
Hobbs, H.H.4
-
15
-
-
79953221100
-
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
-
Coronary Artery Disease C4D Genetics Consortium (2011) A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat Genet 43: 339–344
-
(2011)
Nat Genet
, vol.43
, pp. 339-344
-
-
-
16
-
-
84944097535
-
A cholesterol-lowering VLP vaccine that targets PCSK9
-
Crossey E, Amar MJA, Sampson M, Peabody J, Schiller JT, Chackerian B, Remaley AT (2015) A cholesterol-lowering VLP vaccine that targets PCSK9. Vaccine 33: 5747–5755
-
(2015)
Vaccine
, vol.33
, pp. 5747-5755
-
-
Crossey, E.1
Amar, M.J.A.2
Sampson, M.3
Peabody, J.4
Schiller, J.T.5
Chackerian, B.6
Remaley, A.T.7
-
17
-
-
2942733214
-
Role of endothelial dysfunction in atherosclerosis
-
Davignon J (2004) Role of endothelial dysfunction in atherosclerosis. Circulation 109: III–27–III–32
-
(2004)
Circulation
, vol.109
, pp. III–27-III–32
-
-
Davignon, J.1
-
18
-
-
34547444929
-
Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice
-
Desai U, Lee EC, Chung K, Gao C, Gay J, Key B, Hansen G, Machajewski D, Platt KA, Sands AT et al (2007) Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice. Proc Natl Acad Sci USA 104: 11766–11771
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 11766-11771
-
-
Desai, U.1
Lee, E.C.2
Chung, K.3
Gao, C.4
Gay, J.5
Key, B.6
Hansen, G.7
Machajewski, D.8
Platt, K.A.9
Sands, A.T.10
-
19
-
-
84887058576
-
Common variants associated with plasma triglycerides and risk for coronary artery disease
-
Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J et al (2013) Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 45: 1345–1352
-
(2013)
Nat Genet
, vol.45
, pp. 1345-1352
-
-
Do, R.1
Willer, C.J.2
Schmidt, E.M.3
Sengupta, S.4
Gao, C.5
Peloso, G.M.6
Gustafsson, S.7
Kanoni, S.8
Ganna, A.9
Chen, J.10
-
20
-
-
84923082408
-
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
-
Do R, Stitziel NO, Won HH, Jørgensen AB, Duga S, Angelica Merlini P, Kiezun A, Farrall M, Goel A, Zuk O et al (2015) Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature 518: 102–106
-
(2015)
Nature
, vol.518
, pp. 102-106
-
-
Do, R.1
Stitziel, N.O.2
Won, H.H.3
Jørgensen, A.B.4
Duga, S.5
Angelica Merlini, P.6
Kiezun, A.7
Farrall, M.8
Goel, A.9
Zuk, O.10
-
21
-
-
67649961412
-
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease
-
Elliott P, Chambers JC, Zhang W, Clarke R, Hopewell JC, Peden JF, Erdmann J, Braund P, Engert JC, Bennett D et al (2009) Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA 302: 37–48
-
(2009)
JAMA
, vol.302
, pp. 37-48
-
-
Elliott, P.1
Chambers, J.C.2
Zhang, W.3
Clarke, R.4
Hopewell, J.C.5
Peden, J.F.6
Erdmann, J.7
Braund, P.8
Engert, J.C.9
Bennett, D.10
-
22
-
-
61349177857
-
New susceptibility locus for coronary artery disease on chromosome 3q22.3
-
Erdmann J, Grosshennig A, Braund PS, König IR, Hengstenberg C, Hall AS, Diemert P, Kathiresan S, Wright B, Tregouet DA et al (2009) New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet 41: 280–282
-
(2009)
Nat Genet
, vol.41
, pp. 280-282
-
-
Erdmann, J.1
Grosshennig, A.2
Braund, P.S.3
König, I.R.4
Hengstenberg, C.5
Hall, A.S.6
Diemert, P.7
Kathiresan, S.8
Wright, B.9
Tregouet, D.A.10
-
23
-
-
84890557979
-
Dysfunctional nitric oxide signalling increases risk of myocardial infarction
-
Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, De Wit C, Kaiser FJ, Braunholz D, Medack A, Fischer M et al (2013) Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature 504: 432–436
-
(2013)
Nature
, vol.504
, pp. 432-436
-
-
Erdmann, J.1
Stark, K.2
Esslinger, U.B.3
Rumpf, P.M.4
Koesling, D.5
De Wit, C.6
Kaiser, F.J.7
Braunholz, D.8
Medack, A.9
Fischer, M.10
-
24
-
-
84892741671
-
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
-
Fitzgerald K, Frank-Kamenetsky M, Shulga-Morskaya S, Liebow A, Bettencourt BR, Sutherland JE, Hutabarat RM, Clausen VA, Karsten V, Cehelsky J et al (2014) Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial. Lancet 383: 60–68
-
(2014)
Lancet
, vol.383
, pp. 60-68
-
-
Fitzgerald, K.1
Frank-Kamenetsky, M.2
Shulga-Morskaya, S.3
Liebow, A.4
Bettencourt, B.R.5
Sutherland, J.E.6
Hutabarat, R.M.7
Clausen, V.A.8
Karsten, V.9
Cehelsky, J.10
-
25
-
-
84942919523
-
SH2B3 is a genetic determinant of cardiac inflammation and fibrosis
-
Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J et al (2015) SH2B3 is a genetic determinant of cardiac inflammation and fibrosis. Circ Cardiovasc Genet 8: 294–304
-
(2015)
Circ Cardiovasc Genet
, vol.8
, pp. 294-304
-
-
Flister, M.J.1
Hoffman, M.J.2
Lemke, A.3
Prisco, S.Z.4
Rudemiller, N.5
O'Meara, C.C.6
Tsaih, S.W.7
Moreno, C.8
Geurts, A.M.9
Lazar, J.10
-
26
-
-
84876515907
-
STRING v9.1: protein-protein interaction networks, with increased coverage and integration
-
Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C et al (2013) STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res 41: D808–D815
-
(2013)
Nucleic Acids Res
, vol.41
, pp. D808-D815
-
-
Franceschini, A.1
Szklarczyk, D.2
Frankild, S.3
Kuhn, M.4
Simonovic, M.5
Roth, A.6
Lin, J.7
Minguez, P.8
Bork, P.9
von Mering, C.10
-
27
-
-
50149101511
-
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
-
Frank-Kamenetsky M, Grefhorst A, Anderson NN, Racie TS, Bramlage B, Akinc A, Butler D, Charisse K, Dorkin R, Fan Y et al (2008) Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci USA 105: 11915–11920
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 11915-11920
-
-
Frank-Kamenetsky, M.1
Grefhorst, A.2
Anderson, N.N.3
Racie, T.S.4
Bramlage, B.5
Akinc, A.6
Butler, D.7
Charisse, K.8
Dorkin, R.9
Fan, Y.10
-
28
-
-
84938401608
-
Antisense inhibition of apolipoprotein C-III in patients with hypertriglyceridemia
-
Gaudet D, Alexander VJ, Baker BF, Brisson D, Tremblay K, Singleton W, Geary RS, Hughes SG, Viney NJ, Graham MJ et al (2015) Antisense inhibition of apolipoprotein C-III in patients with hypertriglyceridemia. N Engl J Med 373: 438–447
-
(2015)
N Engl J Med
, vol.373
, pp. 438-447
-
-
Gaudet, D.1
Alexander, V.J.2
Baker, B.F.3
Brisson, D.4
Tremblay, K.5
Singleton, W.6
Geary, R.S.7
Hughes, S.G.8
Viney, N.J.9
Graham, M.J.10
-
29
-
-
84975795680
-
An integrated map of genetic variation from 1,092 human genomes
-
1000 Genomes Project Consortium (2012) An integrated map of genetic variation from 1,092 human genomes. Nature 491: 56–65
-
(2012)
Nature
, vol.491
, pp. 56-65
-
-
-
30
-
-
84880721470
-
Riociguat for the treatment of pulmonary arterial hypertension
-
Ghofrani HA, Galiè N, Grimminger F, Grünig E, Humbert M, Jing Z-C, Keogh AM, Langleben D, Kilama MO, Fritsch A et al (2013) Riociguat for the treatment of pulmonary arterial hypertension. N Engl J Med 369: 330–340
-
(2013)
N Engl J Med
, vol.369
, pp. 330-340
-
-
Ghofrani, H.A.1
Galiè, N.2
Grimminger, F.3
Grünig, E.4
Humbert, M.5
Jing, Z.-C.6
Keogh, A.M.7
Langleben, D.8
Kilama, M.O.9
Fritsch, A.10
-
31
-
-
61349089164
-
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
-
Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, Thorleifsson G, Helgadottir H, Steinthorsdottir V, Stefansson H et al (2009) Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet 41: 342–347
-
(2009)
Nat Genet
, vol.41
, pp. 342-347
-
-
Gudbjartsson, D.F.1
Bjornsdottir, U.S.2
Halapi, E.3
Helgadottir, A.4
Sulem, P.5
Jonsdottir, G.M.6
Thorleifsson, G.7
Helgadottir, H.8
Steinthorsdottir, V.9
Stefansson, H.10
-
32
-
-
34250010480
-
A common variant on chromosome 9p21 affects the risk of myocardial infarction
-
Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, Jonasdottir A, Sigurdsson A, Baker A, Palsson A et al (2007) A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 316: 1491–1493
-
(2007)
Science
, vol.316
, pp. 1491-1493
-
-
Helgadottir, A.1
Thorleifsson, G.2
Manolescu, A.3
Gretarsdottir, S.4
Blondal, T.5
Jonasdottir, A.6
Jonasdottir, A.7
Sigurdsson, A.8
Baker, A.9
Palsson, A.10
-
33
-
-
77649166974
-
ANRIL expression is associated with atherosclerosis risk at chromosome 9p21
-
Holdt LM, Beutner F, Scholz M, Gielen S, Gäbel G, Bergert H, Schuler G, Thiery J, Teupser D (2010) ANRIL expression is associated with atherosclerosis risk at chromosome 9p21. Arterioscler Thromb Vasc Biol 30: 620–627
-
(2010)
Arterioscler Thromb Vasc Biol
, vol.30
, pp. 620-627
-
-
Holdt, L.M.1
Beutner, F.2
Scholz, M.3
Gielen, S.4
Gäbel, G.5
Bergert, H.6
Schuler, G.7
Thiery, J.8
Teupser, D.9
-
34
-
-
84880799429
-
Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks
-
Holdt LM, Hoffmann S, Sass K, Langenberger D, Scholz M, Krohn K, Finstermeier K, Stahringer A, Wilfert W, Beutner F et al (2013) Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. PLoS Genet 9: e1003588
-
(2013)
PLoS Genet
, vol.9
-
-
Holdt, L.M.1
Hoffmann, S.2
Sass, K.3
Langenberger, D.4
Scholz, M.5
Krohn, K.6
Finstermeier, K.7
Stahringer, A.8
Wilfert, W.9
Beutner, F.10
-
35
-
-
84879121298
-
A systems biology framework identifies molecular underpinnings of coronary heart disease
-
Huan T, Zhang B, Wang Z, Joehanes R, Zhu J, Johnson AD, Ying S, Munson PJ, Raghavachari N, Wang R et al (2013) A systems biology framework identifies molecular underpinnings of coronary heart disease. Arterioscler Thromb Vasc Biol 33: 1427–1434
-
(2013)
Arterioscler Thromb Vasc Biol
, vol.33
, pp. 1427-1434
-
-
Huan, T.1
Zhang, B.2
Wang, Z.3
Joehanes, R.4
Zhu, J.5
Johnson, A.D.6
Ying, S.7
Munson, P.J.8
Raghavachari, N.9
Wang, R.10
-
36
-
-
84864335233
-
Genetic markers enhance coronary risk prediction in men: the MORGAM prospective cohorts
-
Hughes M, Saarela O, Stritzke J, Kee F, Silander K, Klopp N, Kontto J, Karvanen J, Willenborg C, Salomaa V et al (2012) Genetic markers enhance coronary risk prediction in men: the MORGAM prospective cohorts. PLoS ONE 7: e40922
-
(2012)
PLoS ONE
, vol.7
-
-
Hughes, M.1
Saarela, O.2
Stritzke, J.3
Kee, F.4
Silander, K.5
Klopp, N.6
Kontto, J.7
Karvanen, J.8
Willenborg, C.9
Salomaa, V.10
-
37
-
-
41349103493
-
Newly identified genetic risk variants for celiac disease related to the immune response
-
Hunt KA, Zhernakova A, Turner G, Heap GAR, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D et al (2008) Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet 40: 395–402
-
(2008)
Nat Genet
, vol.40
, pp. 395-402
-
-
Hunt, K.A.1
Zhernakova, A.2
Turner, G.3
Heap, G.A.R.4
Franke, L.5
Bruinenberg, M.6
Romanos, J.7
Dinesen, L.C.8
Ryan, A.W.9
Panesar, D.10
-
38
-
-
80053452394
-
Large-scale gene-centric analysis identifies novel variants for coronary artery disease
-
IBC 50K CAD Consortium (2011) Large-scale gene-centric analysis identifies novel variants for coronary artery disease. PLoS Genet 7: e1002260
-
(2011)
PLoS Genet
, vol.7
-
-
-
39
-
-
80053907554
-
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
-
International Consortium for Blood Pressure Genome-Wide Association Studies (2011) Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 478: 103–109
-
(2011)
Nature
, vol.478
, pp. 103-109
-
-
-
40
-
-
0033613226
-
Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats
-
Iruela-Arispe ML, Lombardo M, Krutzsch HC, Lawler J, Roberts DD (1999) Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats. Circulation 100: 1423–1431
-
(1999)
Circulation
, vol.100
, pp. 1423-1431
-
-
Iruela-Arispe, M.L.1
Lombardo, M.2
Krutzsch, H.C.3
Lawler, J.4
Roberts, D.D.5
-
41
-
-
84930535796
-
Precision medicine–personalized, problematic, and promising
-
Jameson JL, Longo DL (2015) Precision medicine–personalized, problematic, and promising. N Engl J Med 372: 2229–2234
-
(2015)
N Engl J Med
, vol.372
, pp. 2229-2234
-
-
Jameson, J.L.1
Longo, D.L.2
-
43
-
-
72949132104
-
Factors of risk in the development of coronary heart disease–six year follow-up experience. The Framingham Study
-
Kannel WB, Dawber TR, Kagan A, Revotskie N, Stokes J (1961) Factors of risk in the development of coronary heart disease–six year follow-up experience. The Framingham Study. Ann Intern Med 55: 33–50
-
(1961)
Ann Intern Med
, vol.55
, pp. 33-50
-
-
Kannel, W.B.1
Dawber, T.R.2
Kagan, A.3
Revotskie, N.4
Stokes, J.5
-
44
-
-
12444270065
-
Malfunction of vascular control in lifestyle-related diseases: endothelial nitric oxide (NO) synthase/NO system in atherosclerosis
-
Kawashima S (2004) Malfunction of vascular control in lifestyle-related diseases: endothelial nitric oxide (NO) synthase/NO system in atherosclerosis. J Pharmacol Sci 96: 411–419
-
(2004)
J Pharmacol Sci
, vol.96
, pp. 411-419
-
-
Kawashima, S.1
-
45
-
-
84929353469
-
ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1
-
Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q et al (2015) ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1. Circulation 131: 1191–1201
-
(2015)
Circulation
, vol.131
, pp. 1191-1201
-
-
Kessler, T.1
Zhang, L.2
Liu, Z.3
Yin, X.4
Huang, Y.5
Wang, Y.6
Fu, Y.7
Mayr, M.8
Ge, Q.9
Xu, Q.10
-
46
-
-
67349208839
-
Genome-wide association study of blood pressure and hypertension
-
Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T et al (2009) Genome-wide association study of blood pressure and hypertension. Nat Genet 41: 677–687
-
(2009)
Nat Genet
, vol.41
, pp. 677-687
-
-
Levy, D.1
Ehret, G.B.2
Rice, K.3
Verwoert, G.C.4
Launer, L.J.5
Dehghan, A.6
Glazer, N.L.7
Morrison, A.C.8
Johnson, A.D.9
Aspelund, T.10
-
47
-
-
84862908949
-
Proprotein convertase subtilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates
-
Liang H, Chaparro-Riggers J, Strop P, Geng T, Sutton JE, Tsai D, Bai L, Abdiche Y, Dilley J, Yu J et al (2012) Proprotein convertase subtilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates. J Pharmacol Exp Ther 340: 228–236
-
(2012)
J Pharmacol Exp Ther
, vol.340
, pp. 228-236
-
-
Liang, H.1
Chaparro-Riggers, J.2
Strop, P.3
Geng, T.4
Sutton, J.E.5
Tsai, D.6
Bai, L.7
Abdiche, Y.8
Dilley, J.9
Yu, J.10
-
48
-
-
84876677420
-
Genetic predisposition to higher blood pressure increases coronary artery disease risk
-
Lieb W, Jansen H, Loley C, Pencina MJ, Nelson CP, Newton-Cheh C, Reilly MP, Assimes TL, Boerwinkle E, Hall AS et al (2013) Genetic predisposition to higher blood pressure increases coronary artery disease risk. Hypertension 61: 995–1001
-
(2013)
Hypertension
, vol.61
, pp. 995-1001
-
-
Lieb, W.1
Jansen, H.2
Loley, C.3
Pencina, M.J.4
Nelson, C.P.5
Newton-Cheh, C.6
Reilly, M.P.7
Assimes, T.L.8
Boerwinkle, E.9
Hall, A.S.10
-
49
-
-
84864407698
-
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease
-
Lu X, Wang L, Chen S, He L, Yang X, Shi Y, Cheng J, Zhang L, Gu CC, Huang J et al (2012) Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet 44: 890–894
-
(2012)
Nat Genet
, vol.44
, pp. 890-894
-
-
Lu, X.1
Wang, L.2
Chen, S.3
He, L.4
Yang, X.5
Shi, Y.6
Cheng, J.7
Zhang, L.8
Gu, C.C.9
Huang, J.10
-
50
-
-
0028330005
-
Genetic susceptibility to death from coronary heart disease in a study of twins
-
Marenberg ME, Risch N, Berkman LF, Floderus B, de Faire U (1994) Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med 330: 1041–1046
-
(1994)
N Engl J Med
, vol.330
, pp. 1041-1046
-
-
Marenberg, M.E.1
Risch, N.2
Berkman, L.F.3
Floderus, B.4
de Faire, U.5
-
51
-
-
33846603166
-
Genetics and heritability of coronary artery disease and myocardial infarction
-
Mayer B, Erdmann J, Schunkert H (2007) Genetics and heritability of coronary artery disease and myocardial infarction. Clin Res Cardiol 96: 1–7
-
(2007)
Clin Res Cardiol
, vol.96
, pp. 1-7
-
-
Mayer, B.1
Erdmann, J.2
Schunkert, H.3
-
52
-
-
34249996115
-
A common allele on chromosome 9 associated with coronary heart disease
-
McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg-Hansen A, Folsom AR et al (2007) A common allele on chromosome 9 associated with coronary heart disease. Science 316: 1488–1491
-
(2007)
Science
, vol.316
, pp. 1488-1491
-
-
McPherson, R.1
Pertsemlidis, A.2
Kavaslar, N.3
Stewart, A.4
Roberts, R.5
Cox, D.R.6
Hinds, D.A.7
Pennacchio, L.A.8
Tybjaerg-Hansen, A.9
Folsom, A.R.10
-
53
-
-
84934277268
-
Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials
-
Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield MJ, Devlin JJ, Nordio F, Hyde CL, Cannon CP, Sacks FM et al (2015) Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials. Lancet 385: 2264–2271
-
(2015)
Lancet
, vol.385
, pp. 2264-2271
-
-
Mega, J.L.1
Stitziel, N.O.2
Smith, J.G.3
Chasman, D.I.4
Caulfield, M.J.5
Devlin, J.J.6
Nordio, F.7
Hyde, C.L.8
Cannon, C.P.9
Sacks, F.M.10
-
54
-
-
9344242375
-
Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis
-
Melichar VO, Behr-Roussel D, Zabel U, Uttenthal LO, Rodrigo J, Rupin A, Verbeuren TJ, Kumar HSA, Schmidt HHHW (2004) Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis. Proc Natl Acad Sci USA 101: 16671–16676
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 16671-16676
-
-
Melichar, V.O.1
Behr-Roussel, D.2
Zabel, U.3
Uttenthal, L.O.4
Rodrigo, J.5
Rupin, A.6
Verbeuren, T.J.7
Kumar, H.S.A.8
Schmidt, H.H.H.W.9
-
55
-
-
84905989323
-
Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN- -producing T cells
-
Mori T, Iwasaki Y, Seki Y, Iseki M, Katayama H, Yamamoto K, Takatsu K, Takaki S (2014) Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN- -producing T cells. J Immunol 193: 1728–1736
-
(2014)
J Immunol
, vol.193
, pp. 1728-1736
-
-
Mori, T.1
Iwasaki, Y.2
Seki, Y.3
Iseki, M.4
Katayama, H.5
Yamamoto, K.6
Takatsu, K.7
Takaki, S.8
-
56
-
-
77955499945
-
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
-
Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM et al (2010) From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature 466: 714–719
-
(2010)
Nature
, vol.466
, pp. 714-719
-
-
Musunuru, K.1
Strong, A.2
Frank-Kamenetsky, M.3
Lee, N.E.4
Ahfeldt, T.5
Sachs, K.V.6
Li, X.7
Li, H.8
Kuperwasser, N.9
Ruda, V.M.10
-
57
-
-
70749096913
-
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
-
Myocardial Infarction Genetics Consortium (2009) Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 41: 334–341
-
(2009)
Nat Genet
, vol.41
, pp. 334-341
-
-
-
58
-
-
84915819121
-
Inactivating mutations in NPC1L1 and protection from coronary heart disease
-
Myocardial Infarction Genetics Consortium Investigators (2014) Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med 371: 2072–2082
-
(2014)
N Engl J Med
, vol.371
, pp. 2072-2082
-
-
-
59
-
-
84925623190
-
Identification of a nonsynonymous polymorphism in the SVEP1 gene associated with altered clinical outcomes in septic shock
-
Nakada T-A, Russell JA, Boyd JH, Thair SA, Walley KR (2015) Identification of a nonsynonymous polymorphism in the SVEP1 gene associated with altered clinical outcomes in septic shock. Crit Care Med 43: 101–108
-
(2015)
Crit Care Med
, vol.43
, pp. 101-108
-
-
Nakada, T.-A.1
Russell, J.A.2
Boyd, J.H.3
Thair, S.A.4
Walley, K.R.5
-
60
-
-
84938292742
-
The support of human genetic evidence for approved drug indications
-
Nelson MR, Tipney H, Painter JL, Shen J, Nicoletti P, Shen Y, Floratos A, Sham PC, Li MJ, Wang J et al (2015) The support of human genetic evidence for approved drug indications. Nat Genet 47: 856–860
-
(2015)
Nat Genet
, vol.47
, pp. 856-860
-
-
Nelson, M.R.1
Tipney, H.2
Painter, J.L.3
Shen, J.4
Nicoletti, P.5
Shen, Y.6
Floratos, A.7
Sham, P.C.8
Li, M.J.9
Wang, J.10
-
61
-
-
67349085063
-
Genome-wide association study identifies eight loci associated with blood pressure
-
Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao J-H, Heath SC, Eyheramendy S et al (2009) Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 41: 666–676
-
(2009)
Nat Genet
, vol.41
, pp. 666-676
-
-
Newton-Cheh, C.1
Johnson, T.2
Gateva, V.3
Tobin, M.D.4
Bochud, M.5
Coin, L.6
Najjar, S.S.7
Zhao, J.-H.8
Heath, S.C.9
Eyheramendy, S.10
-
62
-
-
84912143324
-
Cardiovascular disease in Europe 2014: epidemiological update
-
Nichols M, Townsend N, Scarborough P, Rayner M (2014) Cardiovascular disease in Europe 2014: epidemiological update. Eur Heart J 35: 2950–2959
-
(2014)
Eur Heart J
, vol.35
, pp. 2950-2959
-
-
Nichols, M.1
Townsend, N.2
Scarborough, P.3
Rayner, M.4
-
63
-
-
84942987885
-
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
-
Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T, Nelson CP, Hopewell JC et al (2015) A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease. Nat Genet 47: 1121–1130
-
(2015)
Nat Genet
, vol.47
, pp. 1121-1130
-
-
Nikpay, M.1
Goel, A.2
Won, H.H.3
Hall, L.M.4
Willenborg, C.5
Kanoni, S.6
Saleheen, D.7
Kyriakou, T.8
Nelson, C.P.9
Hopewell, J.C.10
-
64
-
-
0031694761
-
Relation of arterial geometry to luminal narrowing and histologic markers for plaque vulnerability: the remodeling paradox
-
Pasterkamp G, Schoneveld AH, van der Wal AC, Haudenschild CC, Clarijs RJ, Becker AE, Hillen B, Borst C (1998) Relation of arterial geometry to luminal narrowing and histologic markers for plaque vulnerability: the remodeling paradox. J Am Coll Cardiol 32: 655–662
-
(1998)
J Am Coll Cardiol
, vol.32
, pp. 655-662
-
-
Pasterkamp, G.1
Schoneveld, A.H.2
van der Wal, A.C.3
Haudenschild, C.C.4
Clarijs, R.J.5
Becker, A.E.6
Hillen, B.7
Borst, C.8
-
65
-
-
79251619566
-
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies
-
Reilly MP, Li M, He J, Ferguson JF, Stylianou IM, Mehta NN, Burnett MS, Devaney JM, Knouff CW, Thompson JR et al (2011) Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet 377: 383–392
-
(2011)
Lancet
, vol.377
, pp. 383-392
-
-
Reilly, M.P.1
Li, M.2
He, J.3
Ferguson, J.F.4
Stylianou, I.M.5
Mehta, N.N.6
Burnett, M.S.7
Devaney, J.M.8
Knouff, C.W.9
Thompson, J.R.10
-
66
-
-
84926191670
-
Efficacy and safety of alirocumab in reducing lipids and cardiovascular events
-
Robinson JG, Farnier M, Krempf M, Bergeron J, Luc G, Averna M, Stroes ES, Langslet G, Raal FJ, El Shahawy M et al (2015) Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med 372: 1489–1499
-
(2015)
N Engl J Med
, vol.372
, pp. 1489-1499
-
-
Robinson, J.G.1
Farnier, M.2
Krempf, M.3
Bergeron, J.4
Luc, G.5
Averna, M.6
Stroes, E.S.7
Langslet, G.8
Raal, F.J.9
El Shahawy, M.10
-
67
-
-
84926206074
-
Efficacy and safety of evolocumab in reducing lipids and cardiovascular events
-
Sabatine MS, Giugliano RP, Wiviott SD, Raal FJ, Blom DJ, Robinson J, Ballantyne CM, Somaratne R, Legg J, Wasserman SM et al (2015) Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med 372: 1500–1509
-
(2015)
N Engl J Med
, vol.372
, pp. 1500-1509
-
-
Sabatine, M.S.1
Giugliano, R.P.2
Wiviott, S.D.3
Raal, F.J.4
Blom, D.J.5
Robinson, J.6
Ballantyne, C.M.7
Somaratne, R.8
Legg, J.9
Wasserman, S.M.10
-
68
-
-
84856261411
-
Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase
-
Salvi E, Kutalik Z, Glorioso N, Benaglio P, Frau F, Kuznetsova T, Arima H, Hoggart C, Tichet J, Nikitin YP et al (2012) Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase. Hypertension 59: 248–255
-
(2012)
Hypertension
, vol.59
, pp. 248-255
-
-
Salvi, E.1
Kutalik, Z.2
Glorioso, N.3
Benaglio, P.4
Frau, F.5
Kuznetsova, T.6
Arima, H.7
Hoggart, C.8
Tichet, J.9
Nikitin, Y.P.10
-
69
-
-
84886381666
-
Target sequencing, cell experiments, and a population study establish endothelial nitric oxide synthase (eNOS) gene as hypertension susceptibility gene
-
Salvi E, Kuznetsova T, Thijs L, Lupoli S, Stolarz-Skrzypek K, D'Avila F, Tikhonoff V, De Astis S, Barcella M, Seidlerova J et al (2013) Target sequencing, cell experiments, and a population study establish endothelial nitric oxide synthase (eNOS) gene as hypertension susceptibility gene. Hypertension 62: 844–852
-
(2013)
Hypertension
, vol.62
, pp. 844-852
-
-
Salvi, E.1
Kuznetsova, T.2
Thijs, L.3
Lupoli, S.4
Stolarz-Skrzypek, K.5
D'Avila, F.6
Tikhonoff, V.7
De Astis, S.8
Barcella, M.9
Seidlerova, J.10
-
70
-
-
34547623750
-
Genomewide association analysis of coronary artery disease
-
Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE et al (2007) Genomewide association analysis of coronary artery disease. N Engl J Med 357: 443–453
-
(2007)
N Engl J Med
, vol.357
, pp. 443-453
-
-
Samani, N.J.1
Erdmann, J.2
Hall, A.S.3
Hengstenberg, C.4
Mangino, M.5
Mayer, B.6
Dixon, R.J.7
Meitinger, T.8
Braund, P.9
Wichmann, H.E.10
-
71
-
-
84864082579
-
Polydom/SVEP1 is a ligand for integrin 91
-
Sato-Nishiuchi R, Nakano I, Ozawa A, Sato Y, Takeichi M, Kiyozumi D, Yamazaki K, Yasunaga T, Futaki S, Sekiguchi K (2012) Polydom/SVEP1 is a ligand for integrin 91. J Biol Chem 287: 25615–25630
-
(2012)
J Biol Chem
, vol.287
, pp. 25615-25630
-
-
Sato-Nishiuchi, R.1
Nakano, I.2
Ozawa, A.3
Sato, Y.4
Takeichi, M.5
Kiyozumi, D.6
Yamazaki, K.7
Yasunaga, T.8
Futaki, S.9
Sekiguchi, K.10
-
72
-
-
55249105922
-
Elevated C-reactive protein in atherosclerosis–chicken or egg?
-
Schunkert H, Samani NJ (2008) Elevated C-reactive protein in atherosclerosis–chicken or egg? N Engl J Med 359: 1953–1955
-
(2008)
N Engl J Med
, vol.359
, pp. 1953-1955
-
-
Schunkert, H.1
Samani, N.J.2
-
73
-
-
41649085340
-
Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease
-
Schunkert H, Götz A, Braund P, McGinnis R, Tregouet DA, Mangino M, Diemert P, Cambien F, Hengstenberg C, Stark K et al (2008) Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation 117: 1675–1684
-
(2008)
Circulation
, vol.117
, pp. 1675-1684
-
-
Schunkert, H.1
Götz, A.2
Braund, P.3
McGinnis, R.4
Tregouet, D.A.5
Mangino, M.6
Diemert, P.7
Cambien, F.8
Hengstenberg, C.9
Stark, K.10
-
74
-
-
79953204259
-
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
-
Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AFR, Barbalic M, Gieger C et al (2011) Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 43: 333–338
-
(2011)
Nat Genet
, vol.43
, pp. 333-338
-
-
Schunkert, H.1
König, I.R.2
Kathiresan, S.3
Reilly, M.P.4
Assimes, T.L.5
Holm, H.6
Preuss, M.7
Stewart, A.F.R.8
Barbalic, M.9
Gieger, C.10
-
75
-
-
84937519974
-
Statin treatment: can genetics sharpen the focus?
-
Schunkert H, Samani NJ (2015) Statin treatment: can genetics sharpen the focus? Lancet 385: 2227–2229
-
(2015)
Lancet
, vol.385
, pp. 2227-2229
-
-
Schunkert, H.1
Samani, N.J.2
-
76
-
-
77952551332
-
Characterization of SVEP1, KIAA, and SRPX2 in an in vitro cell culture model of endotoxemia
-
Schwanzer-Pfeiffer D, Rossmanith E, Schildberger A, Falkenhagen D (2010) Characterization of SVEP1, KIAA, and SRPX2 in an in vitro cell culture model of endotoxemia. Cell Immunol 263: 65–70
-
(2010)
Cell Immunol
, vol.263
, pp. 65-70
-
-
Schwanzer-Pfeiffer, D.1
Rossmanith, E.2
Schildberger, A.3
Falkenhagen, D.4
-
77
-
-
0032868451
-
Coronary artery disease: arterial remodelling and clinical presentation
-
Smits PC, Pasterkamp G, van Ufford MAQ, Eefting FD, Stella PR, de Jaegere PPT, Borst C (1999) Coronary artery disease: arterial remodelling and clinical presentation. Heart 82: 461–464
-
(1999)
Heart
, vol.82
, pp. 461-464
-
-
Smits, P.C.1
Pasterkamp, G.2
van Ufford, M.A.Q.3
Eefting, F.D.4
Stella, P.R.5
de Jaegere, P.P.T.6
Borst, C.7
-
78
-
-
70350644759
-
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
-
Soranzo N, Spector TD, Mangino M, Kühnel B, Rendon A, Teumer A, Willenborg C, Wright B, Chen L, Li M et al (2009) A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet 41: 1182–1190
-
(2009)
Nat Genet
, vol.41
, pp. 1182-1190
-
-
Soranzo, N.1
Spector, T.D.2
Mangino, M.3
Kühnel, B.4
Rendon, A.5
Teumer, A.6
Willenborg, C.7
Wright, B.8
Chen, L.9
Li, M.10
-
79
-
-
61749096117
-
NO-independent, haem-dependent soluble guanylate cyclase stimulators
-
Stasch J-P, Hobbs AJ (2009) NO-independent, haem-dependent soluble guanylate cyclase stimulators. Handb Exp Pharmacol 191: 277–308
-
(2009)
Handb Exp Pharmacol
, vol.191
, pp. 277-308
-
-
Stasch, J.-P.1
Hobbs, A.J.2
-
80
-
-
34548158023
-
Thrombospondins, their polymorphisms, and cardiovascular disease
-
Stenina OI, Topol EJ, Plow EF (2007) Thrombospondins, their polymorphisms, and cardiovascular disease. Arterioscler Thromb Vasc Biol 27: 1886–1894
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 1886-1894
-
-
Stenina, O.I.1
Topol, E.J.2
Plow, E.F.3
-
81
-
-
84962230620
-
Coding variation in ANGPTL4, LPL, and SVEP1 and risk of coronary disease
-
Stitziel NO, Stirrups KE, Masca NG, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR, Auer PL, Schick UM et al (2016) Coding variation in ANGPTL4, LPL, and SVEP1 and risk of coronary disease. N Engl J Med 374: 1134–1144
-
(2016)
N Engl J Med
, vol.374
, pp. 1134-1144
-
-
Stitziel, N.O.1
Stirrups, K.E.2
Masca, N.G.3
Erdmann, J.4
Ferrario, P.G.5
König, I.R.6
Weeke, P.E.7
Webb, T.R.8
Auer, P.L.9
Schick, U.M.10
-
82
-
-
84872166189
-
Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure
-
Swirski FK, Nahrendorf M (2013) Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science 339: 161–166
-
(2013)
Science
, vol.339
, pp. 161-166
-
-
Swirski, F.K.1
Nahrendorf, M.2
-
83
-
-
74949127673
-
Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo
-
Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N et al (2010) Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. J Clin Invest 120: 179–190
-
(2010)
J Clin Invest
, vol.120
, pp. 179-190
-
-
Takizawa, H.1
Nishimura, S.2
Takayama, N.3
Oda, A.4
Nishikii, H.5
Morita, Y.6
Kakinuma, S.7
Yamazaki, S.8
Okamura, S.9
Tamura, N.10
-
84
-
-
77955505564
-
Biological, clinical and population relevance of 95 loci for blood lipids
-
Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ et al (2010) Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466: 707–713
-
(2010)
Nature
, vol.466
, pp. 707-713
-
-
Teslovich, T.M.1
Musunuru, K.2
Smith, A.V.3
Edmondson, A.C.4
Stylianou, I.M.5
Koseki, M.6
Pirruccello, J.P.7
Ripatti, S.8
Chasman, D.I.9
Willer, C.J.10
-
85
-
-
84903727023
-
Loss-of-function mutations in APOC3, triglycerides, and coronary disease
-
The TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung, and Blood Institute (2014) Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med 371: 22–31
-
(2014)
N Engl J Med
, vol.371
, pp. 22-31
-
-
-
86
-
-
61349137526
-
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
-
Tregouet DA, König IR, Erdmann J, Munteanu A, Braund PS, Hall AS, Grosshennig A, Diemert P, Perret C, Desuremain M et al (2009) Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet 41: 283–285
-
(2009)
Nat Genet
, vol.41
, pp. 283-285
-
-
Tregouet, D.A.1
König, I.R.2
Erdmann, J.3
Munteanu, A.4
Braund, P.S.5
Hall, A.S.6
Grosshennig, A.7
Diemert, P.8
Perret, C.9
Desuremain, M.10
-
87
-
-
33846118743
-
Platelets as immune cells: bridging inflammation and cardiovascular disease
-
Von Hundelshausen P, Weber C (2007) Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ Res 100: 27–40
-
(2007)
Circ Res
, vol.100
, pp. 27-40
-
-
Von Hundelshausen, P.1
Weber, C.2
-
88
-
-
63649122439
-
ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries
-
Wang L, Zheng J, Bai X, Liu B, Liu C-J, Xu Q, Zhu Y, Wang N, Kong W, Wang X (2009) ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries. Circ Res 104: 688–698
-
(2009)
Circ Res
, vol.104
, pp. 688-698
-
-
Wang, L.1
Zheng, J.2
Bai, X.3
Liu, B.4
Liu, C.-J.5
Xu, Q.6
Zhu, Y.7
Wang, N.8
Kong, W.9
Wang, X.10
-
89
-
-
77649099042
-
Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin
-
Wang L, Zheng J, Du Y, Huang Y, Li J, Liu B, Liu C-J, Zhu Y, Gao Y, Xu Q et al (2010) Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin. Circ Res 106: 514–525
-
(2010)
Circ Res
, vol.106
, pp. 514-525
-
-
Wang, L.1
Zheng, J.2
Du, Y.3
Huang, Y.4
Li, J.5
Liu, B.6
Liu, C.-J.7
Zhu, Y.8
Gao, Y.9
Xu, Q.10
-
90
-
-
79953207296
-
Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population
-
Wang F, Xu CQ, He Q, Cai JP, Li XC, Wang D, Xiong X, Liao YH, Zeng QT, Yang YZ et al (2011) Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nat Genet 43: 345–349
-
(2011)
Nat Genet
, vol.43
, pp. 345-349
-
-
Wang, F.1
Xu, C.Q.2
He, Q.3
Cai, J.P.4
Li, X.C.5
Wang, D.6
Xiong, X.7
Liao, Y.H.8
Zeng, Q.T.9
Yang, Y.Z.10
-
91
-
-
84944358132
-
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index
-
Yang J, Bakshi A, Zhu Z, Hemani G, Vinkhuyzen AA, Lee SH, Robinson MR, Perry JR, Nolte IM, van Vliet-Ostaptchouk JV et al (2015) Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nat Genet 47: 1114–1120.
-
(2015)
Nat Genet
, vol.47
, pp. 1114-1120
-
-
Yang, J.1
Bakshi, A.2
Zhu, Z.3
Hemani, G.4
Vinkhuyzen, A.A.5
Lee, S.H.6
Robinson, M.R.7
Perry, J.R.8
Nolte, I.M.9
van Vliet-Ostaptchouk, J.V.10
-
92
-
-
4444382796
-
Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
-
Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J et al (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 364: 937–952
-
(2004)
Lancet
, vol.364
, pp. 937-952
-
-
Yusuf, S.1
Hawken, S.2
Ounpuu, S.3
Dans, T.4
Avezum, A.5
Lanas, F.6
McQueen, M.7
Budaj, A.8
Pais, P.9
Varigos, J.10
-
93
-
-
55249087635
-
Genetically elevated C-reactive protein and ischemic vascular disease
-
Zacho J, Tybjaerg-Hansen A, Jensen JS, Grande P, Sillesen H, Nordestgaard BG (2008) Genetically elevated C-reactive protein and ischemic vascular disease. N Engl J Med 359: 1897–1908
-
(2008)
N Engl J Med
, vol.359
, pp. 1897-1908
-
-
Zacho, J.1
Tybjaerg-Hansen, A.2
Jensen, J.S.3
Grande, P.4
Sillesen, H.5
Nordestgaard, B.G.6
|