메뉴 건너뛰기




Volumn 11, Issue 12, 2010, Pages 855-866

Phenomics: The next challenge

Author keywords

[No Author keywords available]

Indexed keywords

EPIGENETICS; GENE EXPRESSION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME; GENOTYPE PHENOTYPE CORRELATION; HERITABILITY; HUMAN; INHERITANCE; PHENOTYPE; PHENOTYPIC VARIATION; PLEIOTROPY; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTOMICS;

EID: 78549246207     PISSN: 14710056     EISSN: 14710064     Source Type: Journal    
DOI: 10.1038/nrg2897     Document Type: Review
Times cited : (1015)

References (127)
  • 1
    • 0023057937 scopus 로고
    • Proposal to sequence the human genome stirs debate
    • Lewin, R. Proposal to sequence the human genome stirs debate. Science 232, 1598-1600 (1986).
    • (1986) Science , vol.232 , pp. 1598-1600
    • Lewin, R.1
  • 2
    • 84902034191 scopus 로고
    • Great 15-year project to decipher genes stirs opposition
    • 5 Jun
    • Angier, N. Great 15-year project to decipher genes stirs opposition. New York Times (5 Jun 1990).
    • (1990) New York Times
    • Angier, N.1
  • 3
    • 0030854184 scopus 로고    scopus 로고
    • Genetics of complex disease - Approaches, problems, and solutions
    • Schork, N. J. Genetics of complex disease - approaches, problems, and solutions. Am. J. Respir. Crit. Care Med. 156, S103-S109 (1997).
    • (1997) Am. J. Respir. Crit. Care Med. , vol.156
    • Schork, N.J.1
  • 4
    • 0033136116 scopus 로고    scopus 로고
    • Toward metabolic phenomics: Analysis of genomic data using flux balances
    • Schilling, C. H., Edwards, J. S. & Palsson, B. O. Toward metabolic phenomics: analysis of genomic data using flux balances. Biotechnol. Prog. 15, 288-295 (1999).
    • (1999) Biotechnol. Prog. , vol.15 , pp. 288-295
    • Schilling, C.H.1    Edwards, J.S.2    Palsson, B.O.3
  • 6
    • 70349560566 scopus 로고    scopus 로고
    • Phenomics: The systematic study of phenotypes on a genome-wide scale
    • Bilder, R. M. et al. Phenomics: the systematic study of phenotypes on a genome-wide scale. Neuroscience 164, 30-42 (2009).
    • (2009) Neuroscience , vol.164 , pp. 30-42
    • Bilder, R.M.1
  • 7
    • 0038670579 scopus 로고    scopus 로고
    • The human phenome project
    • Freimer, N. & Sabatti, C. The human phenome project. Nature Genet. 34, 15-21 (2003).
    • (2003) Nature Genet , vol.34 , pp. 15-21
    • Freimer, N.1    Sabatti, C.2
  • 8
    • 0034352177 scopus 로고    scopus 로고
    • Strategies for the physiome project
    • Bassingthwaighte, J. B. Strategies for the physiome project. Ann. Biomed. Eng. 28, 1043-1058 (2000).
    • (2000) Ann. Biomed. Eng. , vol.28 , pp. 1043-1058
    • Bassingthwaighte, J.B.1
  • 9
    • 0040454380 scopus 로고
    • Phenetics of natural populations I. Phenetic relationships of insular populations of the side-blotched lizard
    • Soulé, M. Phenetics of natural populations I. Phenetic relationships of insular populations of the side-blotched lizard. Evolution 21, 584-591 (1967).
    • (1967) Evolution , vol.21 , pp. 584-591
    • Soulé, M.1
  • 11
    • 84971185409 scopus 로고
    • The correlation between relatives on the supposition of Mendelian inheritance
    • Fisher, R. The correlation between relatives on the supposition of Mendelian inheritance. Trans. R. Soc. Edinb. Earth Sci. 52, 399-433 (1918).
    • (1918) Trans. R. Soc. Edinb. Earth Sci. , vol.52 , pp. 399-433
    • Fisher, R.1
  • 13
    • 0002795621 scopus 로고
    • Mathematical contributions to the theory of evolution. XI. on the influence of natural selection on the variability and correlation of organs
    • Pearson, K. Mathematical contributions to the theory of evolution. XI. On the influence of natural selection on the variability and correlation of organs. Philos. Trans. R. Soc. Lond. A 200, 1-66 (1903).
    • (1903) Philos. Trans. R. Soc. Lond. A , vol.200 , pp. 1-66
    • Pearson, K.1
  • 14
    • 0001589778 scopus 로고
    • Correlation and causation
    • Wright, S. Correlation and causation. J. Agric. Res. 20, 557-585 (1921).
    • (1921) J. Agric. Res. , vol.20 , pp. 557-585
    • Wright, S.1
  • 15
    • 0035400051 scopus 로고    scopus 로고
    • Genetical genomics: The added value from segregation
    • Jansen, R. C. & Nap, J. P. Genetical genomics: the added value from segregation. Trends Genet. 17, 388-391 (2001).
    • (2001) Trends Genet , vol.17 , pp. 388-391
    • Jansen, R.C.1    Nap, J.P.2
  • 16
    • 0037306536 scopus 로고    scopus 로고
    • Studying complex biological systems using multifactorial perturbation
    • Jansen, R. C. Studying complex biological systems using multifactorial perturbation. Nature Rev. Genet. 4, 145-151 (2003).
    • (2003) Nature Rev. Genet. , vol.4 , pp. 145-151
    • Jansen, R.C.1
  • 17
    • 57649124192 scopus 로고    scopus 로고
    • Reverse engineering the genotype- phenotype map with natural genetic variation
    • Rockman, M. V. Reverse engineering the genotype- phenotype map with natural genetic variation. Nature 456, 738-744 (2008).
    • (2008) Nature , vol.456 , pp. 738-744
    • Rockman, M.V.1
  • 18
    • 41349102014 scopus 로고    scopus 로고
    • Pleiotropic scaling of gene effects and the 'cost of complexity'
    • Wagner, G. P. et al. Pleiotropic scaling of gene effects and the 'cost of complexity'. Nature 452, 470-472 (2008).
    • (2008) Nature , vol.452 , pp. 470-472
    • Wagner, G.P.1
  • 19
    • 33747817940 scopus 로고    scopus 로고
    • Toward a molecular understanding of pleiotropy
    • He, X. L. & Zhang, J. Z. Toward a molecular understanding of pleiotropy. Genetics 173, 1885-1891 (2006).
    • (2006) Genetics , vol.173 , pp. 1885-1891
    • He, X.L.1    Zhang, J.Z.2
  • 20
    • 78149257568 scopus 로고    scopus 로고
    • Genomic patterns of pleiotropy and the evolution of complexity
    • Wang, Z., Liao, B. & Zhang, J. Genomic patterns of pleiotropy and the evolution of complexity. Proc. Natl Acad. Sci. USA 107, 18034-18039 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 18034-18039
    • Wang, Z.1    Liao, B.2    Zhang, J.3
  • 21
    • 0018968051 scopus 로고
    • Foraging strategies of Drosophila melanogaster: A chromosomal analysis
    • Sokolowski, M. B. Foraging strategies of Drosophila melanogaster: a chromosomal analysis. Behav. Genet. 10, 291-302 (1980).
    • (1980) Behav. Genet. , vol.10 , pp. 291-302
    • Sokolowski, M.B.1
  • 22
    • 70149108991 scopus 로고    scopus 로고
    • The Drosophila foraging gene mediates adult plasticity and gene-environment interactions in behaviour, metabolites, and gene expression in response to food deprivation
    • Kent, C. F., Daskalchuk, T., Cook, L., Sokolowski, M. B. & Greenspan, R. J. The Drosophila foraging gene mediates adult plasticity and gene-environment interactions in behaviour, metabolites, and gene expression in response to food deprivation. PLoS Genet. 5, e1000609 (2009).
    • (2009) PLoS Genet , vol.5
    • Kent, C.F.1    Daskalchuk, T.2    Cook, L.3    Sokolowski, M.B.4    Greenspan, R.J.5
  • 23
    • 77957947562 scopus 로고    scopus 로고
    • Hundreds of variants clustered in genomic loci and biological pathways affect human height
    • Lango Allen, H. et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467, 832-838 (2010).
    • (2010) Nature , vol.467 , pp. 832-838
    • Lango Allen, H.1
  • 24
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio, T. A. et al. Finding the missing heritability of complex diseases. Nature 461, 747-753 (2009).
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1
  • 25
    • 77954133026 scopus 로고    scopus 로고
    • Estimation of effect size distribution from genome-wide association studies and implications for future discoveries
    • Park, J. et al. Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nature Genet. 42, 570-575 (2010).
    • (2010) Nature Genet , vol.42 , pp. 570-575
    • Park, J.1
  • 26
    • 77955505564 scopus 로고    scopus 로고
    • Biological, clinical and population relevance of 95 loci for blood lipids
    • Teslovich, T. M. et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707-713 (2010).
    • (2010) Nature , vol.466 , pp. 707-713
    • Teslovich, T.M.1
  • 27
    • 55549147191 scopus 로고    scopus 로고
    • Personal genomes: The case of the missing heritability
    • Maher, B. Personal genomes: the case of the missing heritability. Nature 456, 18-21 (2008).
    • (2008) Nature , vol.456 , pp. 18-21
    • Maher, B.1
  • 28
    • 77954140531 scopus 로고    scopus 로고
    • Common SNPs explain a large proportion of the heritability for human height
    • Yang, J. et al. Common SNPs explain a large proportion of the heritability for human height. Nature Genet. 42, 565-569 (2010).
    • (2010) Nature Genet , vol.42 , pp. 565-569
    • Yang, J.1
  • 29
    • 65949107547 scopus 로고    scopus 로고
    • Common genetic variation and human traits
    • Goldstein, D. B. Common genetic variation and human traits. N. Engl. J. Med. 360, 1696-1698 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1696-1698
    • Goldstein, D.B.1
  • 30
    • 75949146309 scopus 로고
    • The number of alleles that can be maintained in a finite population
    • Kimura, M. & Crow, J. F. The number of alleles that can be maintained in a finite population. Genetics 49, 725-738 (1964).
    • (1964) Genetics , vol.49 , pp. 725-738
    • Kimura, M.1    Crow, J.F.2
  • 32
    • 75449111415 scopus 로고    scopus 로고
    • Understanding and using quantitative genetic variation
    • Hill, W. G. Understanding and using quantitative genetic variation. Philos. Trans. R. Soc. B 365, 73-85 (2010).
    • (2010) Philos. Trans. R. Soc. B , vol.365 , pp. 73-85
    • Hill, W.G.1
  • 33
    • 74049138315 scopus 로고    scopus 로고
    • Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
    • Li, S. X. et al. Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. American Journal of Clinical Nutrition 91, 184-190 (2010).
    • (2010) American Journal of Clinical Nutrition , vol.91 , pp. 184-190
    • Li, S.X.1
  • 34
    • 56349096931 scopus 로고    scopus 로고
    • Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
    • Lango, H. et al. Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 57, 3129-3135 (2008).
    • (2008) Diabetes , vol.57 , pp. 3129-3135
    • Lango, H.1
  • 35
    • 56749101779 scopus 로고    scopus 로고
    • Genotype score in addition to common risk factors for prediction of type 2 diabetes
    • Meigs, J. B. et al. Genotype score in addition to common risk factors for prediction of type 2 diabetes. N. Engl. J. Med. 359, 2208-2219 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 2208-2219
    • Meigs, J.B.1
  • 36
    • 77949578084 scopus 로고    scopus 로고
    • Performance of common genetic variants in breast-cancer risk models
    • Wacholder, S. et al. Performance of common genetic variants in breast-cancer risk models. N. Engl. J. Med. 362, 986-993 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 986-993
    • Wacholder, S.1
  • 37
    • 76249109928 scopus 로고    scopus 로고
    • Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study
    • Talmud, P. J. et al. Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. BMJ 340, b4838 (2010).
    • (2010) BMJ , vol.340
    • Talmud, P.J.1
  • 38
    • 67349169201 scopus 로고    scopus 로고
    • Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction
    • Sparsø, T. et al. Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction. Diabetologia 52, 1308-1314 (2009).
    • (2009) Diabetologia , vol.52 , pp. 1308-1314
    • Sparsø, T.1
  • 39
    • 33745607870 scopus 로고    scopus 로고
    • Dissecting complex disease: The quest for the philosopher's stone?
    • Buchanan, A. V., Weiss, K. M. & Fullerton, S. M. Dissecting complex disease: the quest for the philosopher's stone? Int. J. Epidemiol. 35, 562-571 (2006).
    • (2006) Int. J. Epidemiol. , vol.35 , pp. 562-571
    • Buchanan, A.V.1    Weiss, K.M.2    Fullerton, S.M.3
  • 40
    • 77954146319 scopus 로고    scopus 로고
    • Measuring sexual selection on females in sex-role-reversed Mormon crickets (Anabrus simplex, Orthoptera: Tettigoniidae)
    • Robson, L. J. & Gwynne, D. T. Measuring sexual selection on females in sex-role-reversed Mormon crickets (Anabrus simplex, Orthoptera: Tettigoniidae). J. Evol. Biol. 23, 1528-1537 (2010).
    • (2010) J. Evol. Biol. , vol.23 , pp. 1528-1537
    • Robson, L.J.1    Gwynne, D.T.2
  • 41
    • 0001214721 scopus 로고
    • The measurement of selection on correlated characters
    • Lande, R. & Arnold, S. J. The measurement of selection on correlated characters. Evolution 37, 1210-1226 (1983).
    • (1983) Evolution , vol.37 , pp. 1210-1226
    • Lande, R.1    Arnold, S.J.2
  • 42
    • 76549110852 scopus 로고    scopus 로고
    • Numbering the hairs on our heads: The shared challenge and promise of phenomics
    • Houle, D. Numbering the hairs on our heads: the shared challenge and promise of phenomics. Proc. Natl Acad. Sci. USA 107, 1793-1799 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 1793-1799
    • Houle, D.1
  • 44
    • 0038823525 scopus 로고    scopus 로고
    • The endophenotype concept in psychiatry: Etymology and strategic intentions
    • Gottesman, I. & Gould, T. D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 160, 636-645 (2003).
    • (2003) Am. J. Psychiatry , vol.160 , pp. 636-645
    • Gottesman, I.1    Gould, T.D.2
  • 45
    • 0035706575 scopus 로고    scopus 로고
    • Variation selection and evolution of function-valued traits
    • Kingsolver, J. G., Gomulkiewicz, R. & Carter, P. A. Variation, selection and evolution of function-valued traits. Genetica 112-113, 87-104 (2001).
    • (2001) Genetica , vol.112-113 , pp. 87-104
    • Kingsolver, J.G.1    Gomulkiewicz, R.2    Carter, P.A.3
  • 47
    • 0001287271 scopus 로고    scopus 로고
    • Regression shrinkage and selection via the Lasso
    • Tibshirani, R. Regression shrinkage and selection via the Lasso. J. R. Stat. Soc. Ser. B 58, 267-288 (1996).
    • (1996) J. R. Stat. Soc. Ser. B , vol.58 , pp. 267-288
    • Tibshirani, R.1
  • 48
    • 19544380541 scopus 로고    scopus 로고
    • The dimensionality of genetic variation for wing shape in Drosophila melanogaster
    • Mezey, J. G. & Houle, D. The dimensionality of genetic variation for wing shape in Drosophila melanogaster. Evolution 59, 1027-1038 (2005).
    • (2005) Evolution , vol.59 , pp. 1027-1038
    • Mezey, J.G.1    Houle, D.2
  • 49
    • 8344261713 scopus 로고    scopus 로고
    • Analysis of the relationship between type traits and functional survival in Canadian Holsteins using a Weibull proportional hazards model
    • Sewalem, A., Kistemaker, G. J., Miglior, F. & Van Doormaal, B. J. Analysis of the relationship between type traits and functional survival in Canadian Holsteins using a Weibull proportional hazards model. J. Dairy Sci. 87, 3938-3946 (2004).
    • (2004) J. Dairy Sci. , vol.87 , pp. 3938-3946
    • Sewalem, A.1    Kistemaker, G.J.2    Miglior, F.3    Van Doormaal, B.J.4
  • 50
    • 77950344077 scopus 로고    scopus 로고
    • Knowledge-based data analysis comes of age
    • Ochs, M. F. Knowledge-based data analysis comes of age. Brief. Bioinformatics 11, 30-39 (2010).
    • (2010) Brief. Bioinformatics , vol.11 , pp. 30-39
    • Ochs, M.F.1
  • 51
    • 3242806720 scopus 로고    scopus 로고
    • An integrative genomics approach to the reconstruction of gene networks in segregating populations
    • Zhu, J. et al. An integrative genomics approach to the reconstruction of gene networks in segregating populations. Cytogenet. Genome Res. 105, 363-374 (2004).
    • (2004) Cytogenet. Genome Res. , vol.105 , pp. 363-374
    • Zhu, J.1
  • 52
    • 33746623411 scopus 로고    scopus 로고
    • Structural model analysis of multiple quantitative traits
    • Li, R. H. et al. Structural model analysis of multiple quantitative traits. PLoS Genet. 2, 1046-1057 (2006).
    • (2006) PLoS Genet , vol.2 , pp. 1046-1057
    • Li, R.H.1
  • 53
    • 33750478832 scopus 로고    scopus 로고
    • Model Selection and Multi?model Inference: A Practical Information?
    • Springer, New York
    • Burnham, K. P. & Anderson, D. R. Model Selection and Multi?model Inference: A Practical Information? Theoretic Approach. (Springer, New York, 2002).
    • (2002) Theoretic Approach
    • Burnham, K.P.1    Anderson, D.R.2
  • 54
    • 1142265325 scopus 로고    scopus 로고
    • The focused information criterion
    • Claeskens, G. & Hjort, N. L. The focused information criterion. J. Am. Stat. Assoc. 98, 900-916 (2003).
    • (2003) J. Am. Stat. Assoc. , vol.98 , pp. 900-916
    • Claeskens, G.1    Hjort, N.L.2
  • 55
    • 0002555784 scopus 로고
    • The multivariate calibration-problem in chemistry solved by the PLS method
    • Wold, S., Martens, H. & Wold, H. The multivariate calibration-problem in chemistry solved by the PLS method. Lect. Notes Math. 973, 286-293 (1983).
    • (1983) Lect. Notes Math. , vol.973 , pp. 286-293
    • Wold, S.1    Martens, H.2    Wold, H.3
  • 56
    • 12744259874 scopus 로고    scopus 로고
    • Identifying SNPs predictive of phenotype using random forests
    • Bureau, A. et al. Identifying SNPs predictive of phenotype using random forests. Genet. Epidemiol. 28, 171-182 (2005).
    • (2005) Genet. Epidemiol. , vol.28 , pp. 171-182
    • Bureau, A.1
  • 57
    • 0000245743 scopus 로고    scopus 로고
    • Statistical modeling: The two cultures
    • Breiman, L. Statistical modeling: the two cultures. Stat. Sci. 16, 199-215 (2001).
    • (2001) Stat. Sci. , vol.16 , pp. 199-215
    • Breiman, L.1
  • 58
    • 75449111415 scopus 로고    scopus 로고
    • Understanding and using quantitative genetic variation
    • Hill, W. G. Understanding and using quantitative genetic variation. Philo. Trans. R. Soc. B 365, 73-85 (2010).
    • (2010) Philo. Trans. R. Soc. B , vol.365 , pp. 73-85
    • Hill, W.G.1
  • 59
    • 49849096996 scopus 로고    scopus 로고
    • When parameters in dynamic models become phenotypes: A case study on flesh pigmentation in the Chinook salmon (Oncorhynchus tshawytscha)
    • Rajasingh, H., Gjuvsland, A. B., Vage, D. I. & Omholt, S. W. When parameters in dynamic models become phenotypes: a case study on flesh pigmentation in the Chinook salmon (Oncorhynchus tshawytscha). Genetics 179, 1113-1118 (2008).
    • (2008) Genetics , vol.179 , pp. 1113-1118
    • Rajasingh, H.1    Gjuvsland, A.B.2    Vage, D.I.3    Omholt, S.W.4
  • 60
    • 0037336350 scopus 로고    scopus 로고
    • Integration from proteins to organs: The Physiome Project
    • Hunter, P. J. & Borg, T. K. Integration from proteins to organs: the Physiome Project. Nature Rev. Mol. Cell Biol. 4, 237-243 (2003).
    • (2003) Nature Rev. Mol. Cell Biol. , vol.4 , pp. 237-243
    • Hunter, P.J.1    Borg, T.K.2
  • 61
    • 0034046086 scopus 로고    scopus 로고
    • Gene regulatory networks generating the phenomena of additivity, dominance and epistasis
    • Omholt, S. W., Plahte, E., Oyehaug, L. & Xiang, K. Gene regulatory networks generating the phenomena of additivity, dominance and epistasis. Genetics 155, 969-980 (2000).
    • (2000) Genetics , vol.155 , pp. 969-980
    • Omholt, S.W.1    Plahte, E.2    Oyehaug, L.3    Xiang, K.4
  • 62
    • 34848851567 scopus 로고    scopus 로고
    • Nonlinear regulation enhances the phenotypic expression of trans-acting genetic polymorphisms
    • Gjuvsland, A. B., Hayes, B. J., Meuwissen, T. H., Plahte, E. & Omholt, S. W. Nonlinear regulation enhances the phenotypic expression of trans-acting genetic polymorphisms. BMC Syst. Biol. 1, 32 (2007).
    • (2007) BMC Syst. Biol. , vol.1 , pp. 32
    • Gjuvsland, A.B.1    Hayes, B.J.2    Meuwissen, T.H.3    Plahte, E.4    Omholt, S.W.5
  • 63
    • 39049084334 scopus 로고    scopus 로고
    • Threshold-dominated regulation hides genetic variation in gene expression networks
    • Gjuvsland, A. B., Plahte, E. & Omholt, S. W. Threshold-dominated regulation hides genetic variation in gene expression networks. BMC Syst. Biol. 1, 57 (2007).
    • (2007) BMC Syst. Biol. , vol.1 , pp. 57
    • Gjuvsland, A.B.1    Plahte, E.2    Omholt, S.W.3
  • 64
    • 2442582443 scopus 로고    scopus 로고
    • The selective values of alleles in a molecular network model are context dependent
    • Peccoud, J. et al. The selective values of alleles in a molecular network model are context dependent. Genetics 166, 1715-1725 (2004).
    • (2004) Genetics , vol.166 , pp. 1715-1725
    • Peccoud, J.1
  • 65
    • 27644439065 scopus 로고    scopus 로고
    • Flowering time control: Gene network modelling and the link to quantitative genetics
    • Welch, S. M., Dong, Z., Roe, J. L. & Das, S. Flowering time control: gene network modelling and the link to quantitative genetics. Aust. J. Agric. Res. 56, 919-936 (2005).
    • (2005) Aust. J. Agric. Res. , vol.56 , pp. 919-936
    • Welch, S.M.1    Dong, Z.2    Roe, J.L.3    Das, S.4
  • 67
    • 27644497087 scopus 로고    scopus 로고
    • Gene-to-phenotype models and complex trait genetics
    • Cooper, M., Podlich, D. W. & Smith, O. S. Gene-to-phenotype models and complex trait genetics. Aust. J. Agric. Res. 56, 895-918 (2005).
    • (2005) Aust. J. Agric. Res. , vol.56 , pp. 895-918
    • Cooper, M.1    Podlich, D.W.2    Smith, O.S.3
  • 68
    • 77950095599 scopus 로고    scopus 로고
    • A computational model of teeth and the developmental origins of morphological variation
    • Salazar-Ciudad, I. & Jernvall, J. A computational model of teeth and the developmental origins of morphological variation. Nature 464, 583-586 (2010).
    • (2010) Nature , vol.464 , pp. 583-586
    • Salazar-Ciudad, I.1    Jernvall, J.2
  • 69
    • 33846581918 scopus 로고    scopus 로고
    • Statistical epistasis is a generic feature of gene regulatory networks
    • Gjuvsland, A. B., Hayes, B. J., Omholt, S. W. & Carlborg, O. Statistical epistasis is a generic feature of gene regulatory networks. Genetics 175, 411-420 (2006).
    • (2006) Genetics , vol.175 , pp. 411-420
    • Gjuvsland, A.B.1    Hayes, B.J.2    Omholt, S.W.3    Carlborg, O.4
  • 70
    • 77949616789 scopus 로고    scopus 로고
    • Allele interaction - Single locus genetics meets regulatory biology
    • Gjuvsland, A. B., Plahte, E., Ådnøy, T. & Omholt, S. W. Allele interaction - single locus genetics meets regulatory biology. PLoS ONE 5, e9379 (2010).
    • (2010) PLoS ONE , vol.5
    • Gjuvsland, A.B.1    Plahte, E.2    Ådnøy, T.3    Omholt, S.W.4
  • 71
    • 77953529580 scopus 로고    scopus 로고
    • A vision and strategy for the virtual physiological human in 2010 and beyond
    • Hunter, P. et al. A vision and strategy for the virtual physiological human in 2010 and beyond. Philos. Trans. R. Soc. A 368, 2595-2614 (2010).
    • (2010) Philos. Trans. R. Soc. A , vol.368 , pp. 2595-2614
    • Hunter, P.1
  • 72
    • 85008066128 scopus 로고    scopus 로고
    • The VPH-Physiome Project: Standards and tools for multiscale modeling in clinical applications
    • Hunter, P. J. & Viceconti, M. The VPH-Physiome Project: standards and tools for multiscale modeling in clinical applications. IEEE Rev. Biomed. Eng. 2, 40-53 (2009).
    • (2009) IEEE Rev. Biomed. Eng. , vol.2 , pp. 40-53
    • Hunter, P.J.1    Viceconti, M.2
  • 73
    • 0034435086 scopus 로고    scopus 로고
    • Computational mechanics of the heart
    • Nash, M. & Hunter, P. Computational mechanics of the heart. J. Elast. 61, 113-141 (2000).
    • (2000) J. Elast. , vol.61 , pp. 113-141
    • Nash, M.1    Hunter, P.2
  • 74
    • 58849167390 scopus 로고    scopus 로고
    • A decade of genome-wide gene expression profiling in acute myeloid leukemia: Flashback and prospects
    • Wouters, B. J., Lowenberg, B. & Delwel, R. A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects. Blood 11 3, 291-298 (2009).
    • (2009) Blood , vol.11 , Issue.3 , pp. 291-298
    • Wouters, B.J.1    Lowenberg, B.2    Delwel, R.3
  • 75
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    • Golub, T. R. et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286, 531-537 (1999).
    • (1999) Science , vol.286 , pp. 531-537
    • Golub, T.R.1
  • 76
    • 66449127752 scopus 로고    scopus 로고
    • Quantitative genomics: Analyzing intraspecific variation using global gene expression polymorphisms or eQTLs
    • Kliebenstein, D. Quantitative genomics: analyzing intraspecific variation using global gene expression polymorphisms or eQTLs. Annu. Rev. Plant Biol. 60, 93-114 (2009).
    • (2009) Annu. Rev. Plant Biol. , vol.60 , pp. 93-114
    • Kliebenstein, D.1
  • 77
    • 0037715339 scopus 로고    scopus 로고
    • A statistical problem for inference to regulatory structure from associations of gene expression measurements with microarrays
    • Chu, T. J., Glymour, C., Scheines, R. & Spirtes, P. A statistical problem for inference to regulatory structure from associations of gene expression measurements with microarrays. Bioinformatics 19, 1147-1152 (2003).
    • (2003) Bioinformatics , vol.19 , pp. 1147-1152
    • Chu, T.J.1    Glymour, C.2    Scheines, R.3    Spirtes, P.4
  • 78
    • 77951867559 scopus 로고    scopus 로고
    • Spatial expression profiles in the Xenopus laevis oocytes measured with qPCR tomography
    • Sindelka, R., Sidova, M., Svec, D. & Kubista, M. Spatial expression profiles in the Xenopus laevis oocytes measured with qPCR tomography. Methods 51, 87-91 (2010).
    • (2010) Methods , vol.51 , pp. 87-91
    • Sindelka, R.1    Sidova, M.2    Svec, D.3    Kubista, M.4
  • 79
    • 55249096894 scopus 로고    scopus 로고
    • Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast
    • De Godoy, L. M. F. et al. Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast. Nature 455, 1251-1254 (2008).
    • (2008) Nature , vol.455 , pp. 1251-1254
    • De Godoy, L.M.F.1
  • 80
    • 77952956167 scopus 로고    scopus 로고
    • Decoding signalling networks by mass spectrometry-based proteomics
    • Choudhary, C. & Mann, M. Decoding signalling networks by mass spectrometry-based proteomics. Nature Rev. Mol. Cell Biol. 11, 427-439 (2010).
    • (2010) Nature Rev. Mol. Cell Biol. , vol.11 , pp. 427-439
    • Choudhary, C.1    Mann, M.2
  • 81
    • 58449134032 scopus 로고    scopus 로고
    • Widely targeted metabolomics based on large-scale MS/MS data for elucidating metabolite accumulation patterns in plants
    • Sawada, Y. et al. Widely targeted metabolomics based on large-scale MS/MS data for elucidating metabolite accumulation patterns in plants. Plant Cell Physiol. 50, 37-47 (2009).
    • (2009) Plant Cell Physiol , vol.50 , pp. 37-47
    • Sawada, Y.1
  • 82
    • 67650709732 scopus 로고    scopus 로고
    • Metabolomics ready for the prime time?
    • Mayr, M. Metabolomics ready for the prime time? Circ. Cardiovasc. Genet. 1, 58-65 (2008).
    • (2008) Circ. Cardiovasc. Genet. , vol.1 , pp. 58-65
    • Mayr, M.1
  • 83
    • 43749087841 scopus 로고    scopus 로고
    • Human metabolic phenotype diversity and its association with diet and blood pressure
    • Holmes, E. et al. Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 453, 396-400 (2008).
    • (2008) Nature , vol.453 , pp. 396-400
    • Holmes, E.1
  • 84
    • 77953667219 scopus 로고    scopus 로고
    • Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events
    • Shah, S. H. et al. Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events. Circ. Cardiovasc. Genet. 3, 207-214 (2010).
    • (2010) Circ. Cardiovasc. Genet. , vol.3 , pp. 207-214
    • Shah, S.H.1
  • 85
    • 77649266028 scopus 로고    scopus 로고
    • Visualization of image data from cells to organisms
    • Walter, T. et al. Visualization of image data from cells to organisms. Nature Methods 7, 479-479 (2010).
    • (2010) Nature Methods , vol.7 , pp. 479-479
    • Walter, T.1
  • 86
    • 34648834404 scopus 로고    scopus 로고
    • Novel throughput phenotyping platforms in plant genetic studies
    • Montes, J. M., Melchinger, A. E. & Reif, J. C. Novel throughput phenotyping platforms in plant genetic studies. Trends Plant Sci. 12, 433-436 (2007).
    • (2007) Trends Plant Sci , vol.12 , pp. 433-436
    • Montes, J.M.1    Melchinger, A.E.2    Reif, J.C.3
  • 87
    • 70449657853 scopus 로고    scopus 로고
    • Temperature responses of roots: Impact on growth, root system architecture and implications for phenotyping
    • Nagel, K. A. et al. Temperature responses of roots: impact on growth, root system architecture and implications for phenotyping. Funct. Plant Biol. 36, 947-959 (2009).
    • (2009) Funct. Plant Biol. , vol.36 , pp. 947-959
    • Nagel, K.A.1
  • 88
    • 33644866861 scopus 로고    scopus 로고
    • Miniature neurologgers for flying pigeons: Multichannel EEG and action and field potentials in combination with GPS recording
    • Vyssotski, A. L. et al. Miniature neurologgers for flying pigeons: multichannel EEG and action and field potentials in combination with GPS recording. J. Neurophysiol. 95, 1263-1273 (2006).
    • (2006) J. Neurophysiol. , vol.95 , pp. 1263-1273
    • Vyssotski, A.L.1
  • 89
    • 77749246194 scopus 로고    scopus 로고
    • A new chamber for studying the behavior of Drosophila
    • Simon, J. C. & Dickinson, M. H. A new chamber for studying the behavior of Drosophila. PLoS ONE 5, e8793 (2010).
    • (2010) PLoS ONE , vol.5
    • Simon, J.C.1    Dickinson, M.H.2
  • 91
    • 33846055383 scopus 로고    scopus 로고
    • Internet vs. paper and pencil administration of questionnaires commonly used in panic/agoraphobia research
    • Carlbring, P. et al. Internet vs. paper and pencil administration of questionnaires commonly used in panic/agoraphobia research. Comput. Human Behav. 23, 1421-1434 (2007).
    • (2007) Comput. Human Behav. , vol.23 , pp. 1421-1434
    • Carlbring, P.1
  • 92
    • 30044445643 scopus 로고    scopus 로고
    • High-dimensional and large-scale phenotyping of yeast mutants
    • Ohya, Y. et al. High-dimensional and large-scale phenotyping of yeast mutants. Proc. Natl Acad. Sci. USA 102, 19015-19020 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 19015-19020
    • Ohya, Y.1
  • 93
    • 46249092235 scopus 로고    scopus 로고
    • Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans
    • Chung, K. H., Crane, M. M. & Lu, H. Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans. Nature Methods 5, 637-643 (2008).
    • (2008) Nature Methods , vol.5 , pp. 637-643
    • Chung, K.H.1    Crane, M.M.2    Lu, H.3
  • 95
    • 55749092742 scopus 로고    scopus 로고
    • Genetics of the Framingham Heart Study population
    • Govindaraju, D. R. et al. Genetics of the Framingham Heart Study population. Adv. Genet. 62, 33-65 (2008).
    • (2008) Adv. Genet. , vol.62 , pp. 33-65
    • Govindaraju, D.R.1
  • 96
    • 33845709506 scopus 로고    scopus 로고
    • Multiple biomarkers for the prediction of first major cardiovascular events and death
    • Wang, T. J. et al. Multiple biomarkers for the prediction of first major cardiovascular events and death. N. Engl. J. Med. 355, 2631-2639 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , pp. 2631-2639
    • Wang, T.J.1
  • 97
    • 34247126863 scopus 로고    scopus 로고
    • Age Gene/Environment Susceptibility-Reykjavik Study: Multidisciplinary applied phenomics
    • Harris, T. B. et al. Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. Am. J. Epidemiol. 165, 1076-1087 (2007).
    • (2007) Am. J. Epidemiol. , vol.165 , pp. 1076-1087
    • Harris, T.B.1
  • 98
    • 63449100039 scopus 로고    scopus 로고
    • Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Design of prospective meta-analyses of genome-wide association studies from 5 cohorts
    • Psaty, B. M. et al. Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ. Cardiovasc. Genet. 2, 73-80 (2009).
    • (2009) Circ. Cardiovasc. Genet. , vol.2 , pp. 73-80
    • Psaty, B.M.1
  • 100
    • 0027369824 scopus 로고
    • A comprehensive evaluation of family history and breast cancer risk. The Utah Population Database
    • Slattery, M. L. & Kerber, R. A. A comprehensive evaluation of family history and breast cancer risk. The Utah Population Database. JAMA 270, 1563-1568 (1993).
    • (1993) JAMA , vol.270 , pp. 1563-1568
    • Slattery, M.L.1    Kerber, R.A.2
  • 101
    • 77953147757 scopus 로고    scopus 로고
    • The Enterprise Data Trust at Mayo Clinic: A semantically integrated warehouse of biomedical data
    • Chute, C. G., Beck, S. A., Fisk, T. B. & Mohr, D. N. The Enterprise Data Trust at Mayo Clinic: a semantically integrated warehouse of biomedical data. JAMA 17, 131-135 (2010).
    • (2010) JAMA , vol.17 , pp. 131-135
    • Chute, C.G.1    Beck, S.A.2    Fisk, T.B.3    Mohr, D.N.4
  • 102
    • 17144466340 scopus 로고    scopus 로고
    • The Danish National Birth Cohort - Its background, structure and aim
    • Olsen, J. et al. The Danish National Birth Cohort - its background, structure and aim. Scand. J. Public Health 29, 300-307 (2001).
    • (2001) Scand. J. Public Health , vol.29 , pp. 300-307
    • Olsen, J.1
  • 103
    • 34748848639 scopus 로고    scopus 로고
    • The NCBI dbGaP database of genotypes and phenotypes
    • Mailman, M. D. et al. The NCBI dbGaP database of genotypes and phenotypes. Nature Genet. 39, 1181-1186 (2007).
    • (2007) Nature Genet , vol.39 , pp. 1181-1186
    • Mailman, M.D.1
  • 104
    • 77953112590 scopus 로고    scopus 로고
    • Microfluidics-enabled phenotyping, imaging, and screening of multicellular organisms
    • Crane, M. M., Chung, K., Stirman, J. & Lu, H. Microfluidics-enabled phenotyping, imaging, and screening of multicellular organisms. Lab Chip 10, 1509-1517 (2010).
    • (2010) Lab Chip , vol.10 , pp. 1509-1517
    • Crane, M.M.1    Chung, K.2    Stirman, J.3    Lu, H.4
  • 105
    • 70849108991 scopus 로고    scopus 로고
    • Drivers of biodiagnostic development
    • Giljohann, D. A. & Mirkin, C. A. Drivers of biodiagnostic development. Nature 462, 461-464 (2009).
    • (2009) Nature , vol.462 , pp. 461-464
    • Giljohann, D.A.1    Mirkin, C.A.2
  • 107
    • 4544321223 scopus 로고    scopus 로고
    • Mouse MRI: Concepts and applications in physiology
    • Pautler, R. G. Mouse MRI: concepts and applications in physiology. Physiology 19, 168-175 (2004).
    • (2004) Physiology , vol.19 , pp. 168-175
    • Pautler, R.G.1
  • 108
    • 19344363256 scopus 로고    scopus 로고
    • Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts
    • How, O. J. et al. Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts. Am. J. Physiol. Heart Circ. Physiol. 288, H2979-H2985 (2005).
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.288
    • How, O.J.1
  • 109
    • 69749084737 scopus 로고    scopus 로고
    • A unique micromechanocalorimeter for simultaneous measurement of heat rate and force production of cardiac trabeculae carneae
    • Han, J. C. et al. A unique micromechanocalorimeter for simultaneous measurement of heat rate and force production of cardiac trabeculae carneae. J. Appl. Physiol. 107, 946-951 (2009).
    • (2009) J. Appl. Physiol. , vol.107 , pp. 946-951
    • Han, J.C.1
  • 110
    • 0031766038 scopus 로고    scopus 로고
    • Extended confocal microscopy of myocardial laminae and collagen network
    • Young, A. A., Legrice, I. J., Young, M. A. & Smaill, B. H. Extended confocal microscopy of myocardial laminae and collagen network. J. Microsc. 192, 139-150 (1998).
    • (1998) J. Microsc. , vol.192 , pp. 139-150
    • Young, A.A.1    Legrice, I.J.2    Young, M.A.3    Smaill, B.H.4
  • 111
    • 0037422592 scopus 로고    scopus 로고
    • Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises. Part I: Aging arteries: A 'set up' for vascular disease
    • Lakatta, E. G. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part I: aging arteries: a 'set up' for vascular disease. Circulation 107, 139-146 (2003).
    • (2003) Circulation , vol.107 , pp. 139-146
    • Lakatta, E.G.1
  • 112
    • 0037458070 scopus 로고    scopus 로고
    • Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises. Part II: The aging heart in health: Links to heart disease
    • Lakatta, E. G. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part II: the aging heart in health: links to heart disease. Circulation 107, 346-354 (2003).
    • (2003) Circulation , vol.107 , pp. 346-354
    • Lakatta, E.G.1
  • 113
    • 0037469206 scopus 로고    scopus 로고
    • Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises. Part III: Cellular and molecular clues to heart and arterial aging
    • Lakatta, E. G. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part III: cellular and molecular clues to heart and arterial aging. Circulation 107, 490-497 (2003).
    • (2003) Circulation , vol.107 , pp. 490-497
    • Lakatta, E.G.1
  • 115
    • 58549110252 scopus 로고    scopus 로고
    • Stochastic modelling for quantitative description of heterogeneous biological systems
    • Wilkinson, D. J. Stochastic modelling for quantitative description of heterogeneous biological systems. Nature Rev. Genet. 10, 122-133 (2009).
    • (2009) Nature Rev. Genet. , vol.10 , pp. 122-133
    • Wilkinson, D.J.1
  • 116
    • 84861122792 scopus 로고
    • (ed. Waddington, C. H.) (Edinburgh Univ. Press
    • Burns, J. in Towards a Theoretical Biology Vol. 3, (ed. Waddington, C. H.) 47-51 (Edinburgh Univ. Press, 1970).
    • (1970) Towards A Theoretical Biology , vol.3 , pp. 47-51
    • Burns, J.1
  • 119
    • 0037322022 scopus 로고    scopus 로고
    • 'Mendelian randomization': Can genetic epidemiology contribute to understanding environmental determinants of disease?
    • Davey Smith, G. & Ebrahim, S. 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int. J. Epidemiol. 32, 1-22 (2003).
    • (2003) Int. J. Epidemiol. , vol.32 , pp. 1-22
    • Davey Smith, G.1    Ebrahim, S.2
  • 120
    • 66149098914 scopus 로고    scopus 로고
    • Lipids, lipid modifying agents and cardiovascular risk: A review of the evidence
    • Preiss, D. & Sattar, N. Lipids, lipid modifying agents and cardiovascular risk: a review of the evidence. Clin. Endocrinol. 70, 815-828 (2009).
    • (2009) Clin. Endocrinol. , vol.70 , pp. 815-828
    • Preiss, D.1    Sattar, N.2
  • 121
    • 70450081001 scopus 로고    scopus 로고
    • Major lipids, apolipoproteins, and risk of vascular disease
    • Emerging Risk Factors Collaboration et al.
    • Emerging Risk Factors Collaboration et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA 302, 1993-2000 (2009).
    • (2009) JAMA , vol.302 , pp. 1993-2000
  • 122
    • 0035812707 scopus 로고    scopus 로고
    • An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing
    • Pennacchio, L. A. et al. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science 294, 169-173 (2001).
    • (2001) Science , vol.294 , pp. 169-173
    • Pennacchio, L.A.1
  • 123
    • 38649132270 scopus 로고    scopus 로고
    • Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    • Kathiresan, S. et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nature Genet. 40, 189-197 (2008).
    • (2008) Nature Genet , vol.40 , pp. 189-197
    • Kathiresan, S.1
  • 124
    • 0023890867 scopus 로고
    • Measuring the accuracy of diagnostic systems
    • Swets, J. A. Measuring the accuracy of diagnostic systems. Science 240, 1285-1293 (1988).
    • (1988) Science , vol.240 , pp. 1285-1293
    • Swets, J.A.1
  • 125
    • 77953194221 scopus 로고    scopus 로고
    • Digital quantification of human eye color highlights genetic association of three new loci
    • Liu, F. et al. Digital quantification of human eye color highlights genetic association of three new loci. PLoS Genet. 6, e1000934 (2010).
    • (2010) PLoS Genet , vol.6
    • Liu, F.1
  • 126
    • 77953233453 scopus 로고    scopus 로고
    • Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines
    • Atwell, S. et al. Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature 465, 627-631 (2010).
    • (2010) Nature , vol.465 , pp. 627-631
    • Atwell, S.1
  • 127
    • 77951961924 scopus 로고    scopus 로고
    • Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster
    • Jumbo-Lucioni, P. et al. Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster. BMC Genomics 11, 297 (2010).
    • (2010) BMC Genomics , vol.11 , pp. 297
    • Jumbo-Lucioni, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.