메뉴 건너뛰기




Volumn 11, Issue 11, 2012, Pages 833-846

Drug repositioning for Alzheimer's disease

(17)  Corbett, Anne a   Pickett, James b   Burns, Alistair c   Corcoran, Jonathan a   Dunnett, Stephen B d   Edison, Paul e   Hagan, Jim J a   Holmes, Clive f   Jones, Emma a   Katona, Cornelius g   Kearns, Ian h   Kehoe, Patrick i   Mudher, Amrit f   Passmore, Anthony j   Shepherd, Nicola k   Walsh, Frank a   Ballard, Clive a  


Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; BAPINEUZUMAB; CALCIUM CHANNEL BLOCKING AGENT; CANDESARTAN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ETRETIN; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; INSULIN; LIRAGLUTIDE; LOSARTAN; MINOCYCLINE; NILVADIPINE; OLMESARTAN; PLACEBO; RAMIPRIL; RETINOID; SEMAGACESTAT; SEROTONIN UPTAKE INHIBITOR; SOLANEZUMAB; SOMATOMEDIN C; TARENFLURBIL; TELMISARTAN; VALSARTAN;

EID: 84868379118     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd3869     Document Type: Review
Times cited : (235)

References (139)
  • 2
    • 80052266213 scopus 로고    scopus 로고
    • The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics
    • Karran, E., Mercken, M. & De Strooper, B. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nature Rev. Drug Discov. 10, 698-712 (2011).
    • (2011) Nature Rev. Drug Discov , vol.10 , pp. 698-712
    • Karran, E.1    Mercken, M.2    De Strooper, B.3
  • 3
    • 77955322042 scopus 로고    scopus 로고
    • Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models
    • Ittner, L. M. et al. Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models. Cell 142, 387-397 (2010).
    • (2010) Cell , vol.142 , pp. 387-397
    • Ittner, L.M.1
  • 4
    • 79952747862 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Ballard, C. et al. Alzheimer's disease. Lancet 377, 1019-1031 (2011).
    • (2011) Lancet , vol.377 , pp. 1019-1031
    • Ballard, C.1
  • 5
    • 79952666442 scopus 로고    scopus 로고
    • Aligning the evidence with practice: NICE guidelines for drug treatment of Alzheimer's disease
    • Ballard, C., Corbett, A. & Sharp, S. Aligning the evidence with practice: NICE guidelines for drug treatment of Alzheimer's disease. Expert Rev. Neurother. 11, 327-329 (2011).
    • (2011) Expert Rev. Neurother , vol.11 , pp. 327-329
    • Ballard, C.1    Corbett, A.2    Sharp, S.3
  • 6
    • 43249122280 scopus 로고    scopus 로고
    • Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: A randomised phase II trial
    • Wilcock, G. K. et al. Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial. Lancet Neurol. 7, 483-493 (2008).
    • (2008) Lancet Neurol , vol.7 , pp. 483-493
    • Wilcock, G.K.1
  • 7
    • 72549105935 scopus 로고    scopus 로고
    • Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: A randomized controlled trial
    • Green, R. C. et al. Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial. JAMA 302, 2557-2564 (2009).
    • (2009) JAMA , vol.302 , pp. 2557-2564
    • Green, R.C.1
  • 8
    • 77956214193 scopus 로고    scopus 로고
    • Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death
    • Zhang, S. T., Hedskog, L., Petersen, C. A. H., Winblad, B. & Ankarcrona, M. Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death. J. Alzheimers Dis. 21, 389-402 (2010).
    • (2010) J. Alzheimers Dis , vol.21 , pp. 389-402
    • Zhang, S.T.1    Hedskog, L.2    Petersen, C.A.H.3    Winblad, B.4    Ankarcrona, M.5
  • 9
    • 84855414394 scopus 로고    scopus 로고
    • Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease
    • D'Onofrio, G. et al. Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease. Expert Opin. Drug Discov. 7, 19-37 (2012).
    • (2012) Expert Opin. Drug Discov , vol.7 , pp. 19-37
    • D'Onofrio, G.1
  • 12
    • 63149148789 scopus 로고    scopus 로고
    • Intracerebroventricular amyloid-β antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice
    • Thakker, D. R. et al. Intracerebroventricular amyloid-β antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc. Natl Acad. Sci. USA 106, 4501-4506 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 4501-4506
    • Thakker, D.R.1
  • 13
    • 73349091534 scopus 로고    scopus 로고
    • A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
    • Salloway, S. et al. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology 73, 2061-2070 (2009).
    • (2009) Neurology , vol.73 , pp. 2061-2070
    • Salloway, S.1
  • 16
    • 84867338003 scopus 로고    scopus 로고
    • Discovery and preclinical validation of drug indications using compendia of public gene expression data
    • Sirota, M. et al. Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci. Transl. Med. 3, 96ra77 (2011).
    • (2011) Sci. Transl. Med , vol.3
    • Sirota, M.1
  • 17
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: Identifying and developing new uses for existing drugs
    • Ashburn, T. T. & Thor, K. B. Drug repositioning: Identifying and developing new uses for existing drugs. Nature Rev. Drug Discov. 3, 673-683 (2004). (Pubitemid 39173508)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.8 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 18
    • 84860746711 scopus 로고    scopus 로고
    • Amantadine: The journey from fighting flu to treating Parkinson disease
    • Hubsher, G., Haider, M. & Okun, M. S. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology 78, 1096-1099 (2012).
    • (2012) Neurology , vol.78 , pp. 1096-1099
    • Hubsher, G.1    Haider, M.2    Okun, M.S.3
  • 19
    • 0029012763 scopus 로고
    • Incidence and risk-factors of vascular dementia and Alzheimers-disease in a defined elderly japanese population-the Hisayama study
    • Yoshitake, T. et al. Incidence and risk-factors of vascular dementia and Alzheimers-disease in a defined elderly japanese population-the Hisayama study. Neurology 45, 1161-1168 (1995).
    • (1995) Neurology , vol.45 , pp. 1161-1168
    • Yoshitake, T.1
  • 22
    • 0037161304 scopus 로고    scopus 로고
    • The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function
    • Posner, H. B. et al. The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function. Neurology 58, 1175-1181 (2002). (Pubitemid 34411860)
    • (2002) Neurology , vol.58 , Issue.8 , pp. 1175-1181
    • Posner, H.B.1    Tang, M.-X.2    Luchsinger, J.3    Lantigua, R.4    Stern, Y.5    Mayeux, R.6
  • 23
    • 22144451172 scopus 로고    scopus 로고
    • The age-dependent relation of blood pressure to cognitive function and dementia
    • DOI 10.1016/S1474-4422(05)70141-1, PII S1474442205701411
    • Qiu, C., Winblad, B. & Fratiglioni, L. The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol. 4, 487-499 (2005). (Pubitemid 40982459)
    • (2005) Lancet Neurology , vol.4 , Issue.8 , pp. 487-499
    • Qiu, C.1    Winblad, B.2    Fratiglioni, L.3
  • 24
    • 75649144979 scopus 로고    scopus 로고
    • Role of vascular risk factors and vascular dysfunction in Alzheimer's disease
    • Dickstein, D. L. et al. Role of vascular risk factors and vascular dysfunction in Alzheimer's disease. Mt Sinai J. Med. 77, 82-102 (2010).
    • (2010) Mt Sinai J. Med , vol.77 , pp. 82-102
    • Dickstein, D.L.1
  • 26
    • 70450045976 scopus 로고    scopus 로고
    • Angiotensins in Alzheimer's disease-friend or foe?
    • Kehoe, P. G., Miners, J. S. & Love, S. Angiotensins in Alzheimer's disease-friend or foe? Trends Neurosci. 32, 619-628 (1997).
    • (1997) Trends Neurosci , vol.32 , pp. 619-628
    • Kehoe, P.G.1    Miners, J.S.2    Love, S.3
  • 27
    • 84860112460 scopus 로고    scopus 로고
    • The renin-angiotensin system and antihypertensive drugs in Alzheimer's disease: Current standing of the angiotensin hypothesis?
    • Kehoe, P. G. & Passmore, P. A. The renin-angiotensin system and antihypertensive drugs in Alzheimer's disease: current standing of the angiotensin hypothesis? J. Alzheimers Dis. 30, S251-S269 (2012).
    • (2012) J. Alzheimers Dis , vol.30
    • Kehoe, P.G.1    Passmore, P.A.2
  • 28
    • 79960675107 scopus 로고    scopus 로고
    • Brain renin-angiotensin-a new look at an old system
    • Wright, J. W. & Harding, J. W. Brain renin-angiotensin-a new look at an old system. Prog. Neurobiol. 95, 49-67 (2011).
    • (2011) Prog. Neurobiol , vol.95 , pp. 49-67
    • Wright, J.W.1    Harding, J.W.2
  • 29
    • 0036672123 scopus 로고    scopus 로고
    • 1-receptor blockers
    • Culman, J., Blume, A., Gohlke, P. & Unger, T. The renin-angiotensin system in the brain: possible therapeutic implications for AT1-receptor blockers. J. Hum. Hypertens. 16, S64-S70 (2002). (Pubitemid 35021380)
    • (2002) Journal of Human Hypertension , vol.16 , Issue.SUPPL. 3
    • Culman, J.1    Blume, A.2    Gohlke, P.3    Unger, T.4
  • 31
    • 79952977933 scopus 로고    scopus 로고
    • Angiotensin II-inhibiting drugs have no effect on intraneuronal Aβ or oligomeric Aβ levels in a triple transgenic mouse model of Alzheimer's disease
    • Ferrington, L. et al. Angiotensin II-inhibiting drugs have no effect on intraneuronal Aβ or oligomeric Aβ levels in a triple transgenic mouse model of Alzheimer's disease. Am. J. Transl. Res. 3, 197-208 (2011).
    • (2011) Am. J. Transl. Res , vol.3 , pp. 197-208
    • Ferrington, L.1
  • 32
    • 33947245344 scopus 로고    scopus 로고
    • Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid β-protein metabolism in mouse models of Alzheimer disease
    • DOI 10.1016/j.nbd.2007.01.004, PII S096999610700023X
    • Hemming, M. L., Selkoe, D. J. & Farris, W. Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid β-protein metabolism in mouse models of Alzheimer disease. Neurobiol. Dis. 26, 273-281 (2007). (Pubitemid 46436503)
    • (2007) Neurobiology of Disease , vol.26 , Issue.1 , pp. 273-281
    • Hemming, M.L.1    Selkoe, D.J.2    Farris, W.3
  • 33
    • 73349097900 scopus 로고    scopus 로고
    • Angiotensin receptor blocker prevented β-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling
    • Takeda, S. et al. Angiotensin receptor blocker prevented β-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling. Hypertension 54, 1345-1352 (2009).
    • (2009) Hypertension , vol.54 , pp. 1345-1352
    • Takeda, S.1
  • 34
    • 50849089332 scopus 로고    scopus 로고
    • Telmisartan prevented cognitive decline partly due to PPAR-γ activation
    • Mogi, M. et al. Telmisartan prevented cognitive decline partly due to PPAR-γ activation. Biochem. Biophys. Res. Commun. 375, 446-449 (2008).
    • (2008) Biochem. Biophys. Res. Commun , vol.375 , pp. 446-449
    • Mogi, M.1
  • 35
    • 77952342062 scopus 로고    scopus 로고
    • Protective effects of intranasal losartan in the APP/PS1 transgenic mouse model of Alzheimer disease
    • Danielyan, L. et al. Protective effects of intranasal losartan in the APP/PS1 transgenic mouse model of Alzheimer disease. Rejuven. Res. 13, 195-201 (2010).
    • (2010) Rejuven. Res , vol.13 , pp. 195-201
    • Danielyan, L.1
  • 36
    • 74949131237 scopus 로고    scopus 로고
    • Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: Prospective cohort analysis
    • Li, N.-C. et al. Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis. BMJ 340, b5465 (2010).
    • (2010) BMJ , vol.340
    • Li, N.-C.1
  • 37
    • 80054843547 scopus 로고    scopus 로고
    • Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias
    • Davies, N. M., Kehoe, P. G., Ben-Shlomo, Y. & Martin, R. M. Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias. J. Alzheimers Dis. 26, 699-708 (2011).
    • (2011) J. Alzheimers Dis , vol.26 , pp. 699-708
    • Davies, N.M.1    Kehoe, P.G.2    Ben-Shlomo, Y.3    Martin, R.M.4
  • 38
    • 78650022206 scopus 로고    scopus 로고
    • Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: Analysis of data from the ONTARGET and TRANSCEND studies
    • Anderson, C. et al. Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies. Lancet Neurol. 10, 43-53 (2011).
    • (2011) Lancet Neurol , vol.10 , pp. 43-53
    • Anderson, C.1
  • 40
    • 23744468024 scopus 로고    scopus 로고
    • Effect of baseline cognitive function and antihypertensive treatment on cognitive and cardiovascular outcomes: Study on COgnition and Prognosis in the Elderly (SCOPE)
    • DOI 10.1016/j.amjhyper.2005.02.013, PII S0895706105001020
    • Skoog, I. et al. Effect of baseline cognitive function and anti hypertensive treatment on cognitive and cardiovascular outcomes: study on cognition and prognosis in the elderly (SCOPE). Am. J. Hypertens. 18, 1052-1059 (2005). (Pubitemid 41139903)
    • (2005) American Journal of Hypertension , vol.18 , Issue.8 , pp. 1052-1059
    • Skoog, I.1    Lithell, H.2    Hansson, L.3    Elmfeldt, D.4    Hofman, A.5    Olofsson, B.6    Trenkwalder, P.7    Zanchetti, A.8
  • 41
    • 0028911939 scopus 로고
    • Nitrendipine and mefruside in elderly hypertensives-effects on blood-pressure, cardiac-output, cerebral blood-flow and metabolic parameters
    • Landmark, K. et al. Nitrendipine and mefruside in elderly hypertensives-effects on blood-pressure, cardiac-output, cerebral blood-flow and metabolic parameters. J. Hum. Hypertens. 9, 281-285 (1995).
    • (1995) J. Hum. Hypertens , vol.9 , pp. 281-285
    • Landmark, K.1
  • 42
    • 34247566711 scopus 로고    scopus 로고
    • Favourable effects of nilvadipine on cognitive function and regional cerebral blood flow on SPECT in hypertensive patients with mild cognitive impairment
    • DOI 10.1097/MNM.0b013e32804c58aa, PII 0000623120070400000009
    • Hanyu, H. et al. Favourable effects of nilvadipine on cognitive function and regional cerebral blood flow on SPECT in hypertensive patients with mild cognitive impairment. Nuclear Med. Commun. 28, 281-287 (2007). (Pubitemid 46673205)
    • (2007) Nuclear Medicine Communications , vol.28 , Issue.4 , pp. 281-287
    • Hanyu, H.1    Hirao, K.2    Shimizu, S.3    Iwamoto, T.4    Koizumi, K.5    Abe, K.6
  • 43
    • 0025053422 scopus 로고
    • Effects of nimodipine on cerebral blood flow and neuropsychological outcome after cardiac surgery
    • Forsman, M., Olsnes, B. T., Semb, G. & Steen, P. A. Effects of nimodipine on cerebral blood flow and neuropsychological outcome after cardiac surgery. Br. J. Anaesth. 65, 514-520 (1990). (Pubitemid 20337999)
    • (1990) British Journal of Anaesthesia , vol.65 , Issue.4 , pp. 514-520
    • Forsman, M.1    Tubylewicz Olsnes, B.2    Semb, G.3    Steen, P.A.4
  • 44
    • 58849148507 scopus 로고    scopus 로고
    • Identification of antihypertensive drugs which inhibit amyloid-β protein oligomerization
    • Zhao, W. et al. Identification of antihypertensive drugs which inhibit amyloid-β protein oligomerization. J. Alzheimers Dis. 16, 49-57 (2009).
    • (2009) J. Alzheimers Dis , vol.16 , pp. 49-57
    • Zhao, W.1
  • 45
    • 79955941709 scopus 로고    scopus 로고
    • Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier
    • Bachmeier, C., Beaulieu-Abdelahad, D., Mullan, M. & Paris, D. Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier. Eur. J. Pharmacol. 659, 124-129 (2011).
    • (2011) Eur. J. Pharmacol , vol.659 , pp. 124-129
    • Bachmeier, C.1    Beaulieu-Abdelahad, D.2    Mullan, M.3    Paris, D.4
  • 46
    • 78349309295 scopus 로고    scopus 로고
    • L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease
    • Anekonda, T. S. et al. L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease. Neurobiol. Dis. 41, 62-70 (2011).
    • (2011) Neurobiol. Dis , vol.41 , pp. 62-70
    • Anekonda, T.S.1
  • 47
    • 34247230363 scopus 로고    scopus 로고
    • 2 against glutamate-induced neurotoxicity in PC12 cells
    • DOI 10.1016/j.jep.2006.12.015, PII S0378874106006611
    • Li, N., Liu, B., Dluzen, D. E. & Jin, Y. Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells. J. Ethnopharmacol. 111, 458-463 (2007). (Pubitemid 46617084)
    • (2007) Journal of Ethnopharmacology , vol.111 , Issue.3 , pp. 458-463
    • Li, N.1    Liu, B.2    Dluzen, D.E.3    Jin, Y.4
  • 48
    • 79952860789 scopus 로고    scopus 로고
    • Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier
    • Paris, D. et al. Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier. Mol. Med. 17, 149-162 (2011).
    • (2011) Mol. Med , vol.17 , pp. 149-162
    • Paris, D.1
  • 50
    • 80052288667 scopus 로고    scopus 로고
    • A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: Isradipine as a candidate drug
    • Copenhaver, P. F. et al. A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug. Dis. Model. Mech. 4, 634-648 (2011).
    • (2011) Dis. Model. Mech , vol.4 , pp. 634-648
    • Copenhaver, P.F.1
  • 51
    • 0036046464 scopus 로고    scopus 로고
    • Nimodipine for primary degenerative, mixed and vascular dementia
    • Lopez-Arrieta, J. M. & Birks, J. Nimodipine for primary degenerative, mixed and vascular dementia. Cochrane Database Syst. Rev. 2002, CD000147 (2002).
    • (2002) Cochrane Database Syst. Rev , vol.2002
    • Lopez-Arrieta, J.M.1    Birks, J.2
  • 52
    • 0026718552 scopus 로고
    • Blocking the Ca2+-activated cytotoxic mechanisms of cholinergic neuronal death: A novel treatment strategy for Alzheimer's disease
    • Branconnier, R. J., Branconnier, M. E., Walshe, T. M., McCarthy, C. & Morse, P. A. Blocking the Ca2+-activated cytotoxic mechanisms of cholinergic neuronal death: a novel treatment strategy for Alzheimer's disease. Psychopharmacol. Bull. 28, 175-181 (1992).
    • (1992) Psychopharmacol. Bull , vol.28 , pp. 175-181
    • Branconnier, R.J.1    Branconnier, M.E.2    Walshe, T.M.3    McCarthy, C.4    Morse, P.A.5
  • 53
    • 0030009517 scopus 로고    scopus 로고
    • Nimodipine in the treatment of probable Alzheimer's disease-results of two multicentre trials
    • Morich, F. J. et al. Nimodipine in the treatment of probable Alzheimer's disease-results of two multicentre trials. Clin. Drug Invest. 11, 185-195 (1996).
    • (1996) Clin. Drug Invest , vol.11 , pp. 185-195
    • Morich, F.J.1
  • 54
    • 80052706430 scopus 로고    scopus 로고
    • Demonstration of safety in Alzheimer's patients for intervention with an anti-hypertensive drug nilvadipine: Results from a 6-week open label study
    • Kennelly, S. P. et al. Demonstration of safety in Alzheimer's patients for intervention with an anti-hypertensive drug nilvadipine: results from a 6-week open label study. Int. J. Geriatr. Psychiatry 26, 1038-1045 (2011).
    • (2011) Int. J. Geriatr. Psychiatry , vol.26 , pp. 1038-1045
    • Kennelly, S.P.1
  • 55
    • 84858339480 scopus 로고    scopus 로고
    • Apolipoprotein e genotype-specific short-term cognitive benefits of treatment with the antihypertensive nilvadipine in Alzheimer's patients-an open-label trial
    • Kennelly, S. et al. Apolipoprotein E genotype-specific short-term cognitive benefits of treatment with the antihypertensive nilvadipine in Alzheimer's patients-an open-label trial. Int. J. Geriatr. Psychiatry 27, 415-422 (2012).
    • (2012) Int. J. Geriatr. Psychiatry , vol.27 , pp. 415-422
    • Kennelly, S.1
  • 56
    • 33646433026 scopus 로고    scopus 로고
    • Antihypertensive medication use and incident Alzheimer disease-the Cache County study
    • Khachaturian, A. S. et al. Antihypertensive medication use and incident Alzheimer disease-the Cache County study. Arch. Neurol. 63, 686-692 (2006).
    • (2006) Arch. Neurol , vol.63 , pp. 686-692
    • Khachaturian, A.S.1
  • 57
    • 0037078312 scopus 로고    scopus 로고
    • The prevention of dementia with antihypertensive treatment
    • Forette, F. et al. The prevention of dementia with antihypertensive treatment. Arch. Intern. Med. 162, 2046-2052 (2002).
    • (2002) Arch. Intern. Med , vol.162 , pp. 2046-2052
    • Forette, F.1
  • 58
    • 78650029989 scopus 로고    scopus 로고
    • Insulin metabolism and the risk of Alzheimer disease-the Rotterdam study
    • Schrijvers, E. M. C. et al. Insulin metabolism and the risk of Alzheimer disease-the Rotterdam study. Neurology 75, 1982-1987 (2010).
    • (2010) Neurology , vol.75 , pp. 1982-1987
    • Schrijvers, E.M.C.1
  • 59
    • 71349085957 scopus 로고    scopus 로고
    • Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
    • Moloney, A. M. et al. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol. Aging 31, 224-243 (2010).
    • (2010) Neurobiol. Aging , vol.31 , pp. 224-243
    • Moloney, A.M.1
  • 60
    • 6344250713 scopus 로고    scopus 로고
    • Insulin and the CNS: Effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans
    • DOI 10.1016/j.physbeh.2004.07.022, PII S0031938404003488
    • Stockhorst, U., de Fries, D., Steingrueber, H. J. & Scherbaum, W. A. Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans. Physiol. Behav. 83, 47-54 (2004). (Pubitemid 39387693)
    • (2004) Physiology and Behavior , vol.83 , Issue.1 SPEC. ISS. , pp. 47-54
    • Stockhorst, U.1    De Fries, D.2    Steingrueber, H.-J.3    Scherbaum, W.A.4
  • 61
    • 27844498075 scopus 로고    scopus 로고
    • Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies
    • Holscher, C. Development of β-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies. Rev. Neurosci. 16, 181-212 (2005). (Pubitemid 41655771)
    • (2005) Reviews in the Neurosciences , vol.16 , Issue.3 , pp. 181-212
    • Holscher, C.1
  • 62
    • 1842785179 scopus 로고    scopus 로고
    • Glucose metabolism and insulin receptor signal transduction in Alzheimer disease
    • DOI 10.1016/j.ejphar.2004.02.049, PII S0014299904002067
    • Hoyer, S. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. Eur. J. Pharmacol. 490, 115-125 (2004). (Pubitemid 38482165)
    • (2004) European Journal of Pharmacology , vol.490 , Issue.1-3 , pp. 115-125
    • Hoyer, S.1
  • 63
    • 36448936053 scopus 로고    scopus 로고
    • Common pathological processes in Alzheimer disease and type 2 diabetes: A review
    • DOI 10.1016/j.brainresrev.2007.09.001, PII S0165017307001907
    • Li, L. & Hlscher, C. Common pathological processes in Alzheimer disease and type 2 diabetes: a review. Brain Res. Rev. 56, 384-402 (2007). (Pubitemid 350166529)
    • (2007) Brain Research Reviews , vol.56 , Issue.2 , pp. 384-402
    • Li, L.1    Holscher, C.2
  • 64
    • 34548249096 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model
    • DOI 10.1111/j.1530-0277.2007.00450.x
    • Cohen, A. C., Tong, M., Wands, J. R. & de la Monte, S. M. Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model. Alcohol Clin. Exp. Res. 31, 1558-1573 (2007). (Pubitemid 47319658)
    • (2007) Alcoholism: Clinical and Experimental Research , vol.31 , Issue.9 , pp. 1558-1573
    • Cohen, A.C.1    Tong, M.2    Wands, J.R.3    De La Monte, S.M.4
  • 65
    • 1842684434 scopus 로고    scopus 로고
    • Insulin-like growth factor-I, cognition and brain aging
    • DOI 10.1016/j.ejphar.2004.02.047, PII S0014299904002043
    • van Dam, P. & Aleman, A. Insulin-like growth factor-I, cognition and brain aging. Eur. J. Pharmacol. 490, 87-95 (2004). (Pubitemid 38482163)
    • (2004) European Journal of Pharmacology , vol.490 , Issue.1-3 , pp. 87-95
    • Van Dam, P.S.1    Aleman, A.2
  • 66
    • 34347377319 scopus 로고    scopus 로고
    • Alzheimer-like changes in rat models of spontaneous diabetes
    • DOI 10.2337/db07-0171
    • Li, Z. G., Zhang, W. & Sima, A. A. Alzheimer-like changes in rat models of spontaneous diabetes. Diabetes 56, 1817-1824 (2007). (Pubitemid 47025451)
    • (2007) Diabetes , vol.56 , Issue.7 , pp. 1817-1824
    • Li, Z.-G.1    Zhang, W.2    Sima, A.A.F.3
  • 67
    • 1842633868 scopus 로고    scopus 로고
    • The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease
    • DOI 10.1016/j.ejphar.2004.02.050, PII S0014299904002079
    • Carro, E. & Torres, A. I. The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease. Eur. J. Pharmacol. 490, 127-133 (2004). (Pubitemid 38482166)
    • (2004) European Journal of Pharmacology , vol.490 , Issue.1-3 , pp. 127-133
    • Carro, E.1    Torres-Aleman, I.2
  • 68
    • 1842734649 scopus 로고    scopus 로고
    • Modulation of memory by insulin and glucose: Neuropsychological observations in Alzheimer's disease
    • DOI 10.1016/j.ejphar.2004.02.048, PII S0014299904002055
    • Watson, G. S. & Craft, S. Modulation of memory by insulin and glucose: neuropsychological observations in Alzheimer's disease. Eur. J. Pharmacol. 490, 97-113 (2004). (Pubitemid 38482164)
    • (2004) European Journal of Pharmacology , vol.490 , Issue.1-3 , pp. 97-113
    • Watson, G.S.1    Craft, S.2
  • 69
    • 1842633872 scopus 로고    scopus 로고
    • Insulin and the insulin receptor in experimental models of learning and memory
    • DOI 10.1016/j.ejphar.2004.02.045, PII S001429990400202X
    • Zhao, W. Q. Chen, H., Quon, M. J. & Alkon, D. L. Insulin and the insulin receptor in experimental models of learning and memory. Eur. J. Pharmacol. 490, 71-81 (2004). (Pubitemid 38482161)
    • (2004) European Journal of Pharmacology , vol.490 , Issue.1-3 , pp. 71-81
    • Zhao, W.-Q.1    Chen, H.2    Quon, M.J.3    Alkon, D.L.4
  • 71
    • 67649372868 scopus 로고    scopus 로고
    • A profile of impaired insulin degradation in relation to late-life cognitive decline: A preliminary investigation
    • Okereke, O. I. et al. A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigation. Int. J. Geriatr. Psychiatry 24, 177-182 (2008).
    • (2008) Int. J. Geriatr. Psychiatry , vol.24 , pp. 177-182
    • Okereke, O.I.1
  • 72
    • 40349091597 scopus 로고    scopus 로고
    • Intranasal insulin improves cognition and modulates β-amyloid in early AD
    • Reger, M. A. et al. Intranasal insulin improves cognition and modulates β-amyloid in early AD. Neurology 70, 440-448 (2008).
    • (2008) Neurology , vol.70 , pp. 440-448
    • Reger, M.A.1
  • 73
    • 78651274000 scopus 로고    scopus 로고
    • Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes
    • Baker, L. D. et al. Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. Arch. Neurol. 68, 51-57 (2010).
    • (2010) Arch. Neurol. , vol.68 , pp. 51-57
    • Baker, L.D.1
  • 74
    • 84855613853 scopus 로고    scopus 로고
    • Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: A pilot clinical trial
    • Craft, S. et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch. Neurol. 69, 29-38 (2012).
    • (2012) Arch. Neurol , vol.69 , pp. 29-38
    • Craft, S.1
  • 76
    • 0038248960 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 decreases endogenous amyloid-β peptide (Aβ) levels and protects hippocampal neurons from death induced by Aβ and iron
    • DOI 10.1002/jnr.10611
    • Perry, T. et al. Glucagon-like peptide-1 decreases endogenous amyloid-β peptide (Aβ) levels and protects hippocampal neurons from death induced by Aβ and iron. J. Neurosci. Res. 72, 603-612 (2003). (Pubitemid 36578646)
    • (2003) Journal of Neuroscience Research , vol.72 , Issue.5 , pp. 603-612
    • Perry, T.1    Lahiri, D.K.2    Sambamurti, K.3    Chen, D.4    Mattson, M.P.5    Egan, J.M.6    Greig, N.H.7
  • 77
    • 84855548096 scopus 로고    scopus 로고
    • (Val8) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains
    • Li, L. et al. (Val8) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. Eur. J. Pharmacol. 674, 280-286 (2012).
    • (2012) Eur. J. Pharmacol , vol.674 , pp. 280-286
    • Li, L.1
  • 79
    • 77957126457 scopus 로고    scopus 로고
    • Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats
    • Wang, X. H. et al. Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats. Neuroscience 170, 1239-1248 (2010).
    • (2010) Neuroscience , vol.170 , pp. 1239-1248
    • Wang, X.H.1
  • 81
    • 82755176046 scopus 로고    scopus 로고
    • Val(8) GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
    • Gengler, S., McClean, P., McCurtin, R., Gault, V. & Holscher, C. Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol. Aging 33, 265-276 (2012).
    • (2012) Neurobiol. Aging , vol.33 , pp. 265-276
    • Gengler, S.1    McClean, P.2    McCurtin, R.3    Gault, V.4    Holscher, C.5
  • 82
    • 79955749452 scopus 로고    scopus 로고
    • The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
    • McClean, P. L., Parthsarathy, V., Faivre, E. & Holscher, C. The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. J. Neurosci. 31, 6587-6594 (2011).
    • (2011) J. Neurosci , vol.31 , pp. 6587-6594
    • McClean, P.L.1    Parthsarathy, V.2    Faivre, E.3    Holscher, C.4
  • 83
    • 79751479118 scopus 로고    scopus 로고
    • Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain
    • Hamilton, A., Patterson, S., Porter, D., Gault, V. A. & Holscher, C. Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain. J. Neurosci. Res. 89, 481-489 (2011).
    • (2011) J. Neurosci. Res , vol.89 , pp. 481-489
    • Hamilton, A.1    Patterson, S.2    Porter, D.3    Gault, V.A.4    Holscher, C.5
  • 84
    • 0036198285 scopus 로고    scopus 로고
    • Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier
    • Kastin, A. J., Akerstrom, V. & Pan, W. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J. Mol. Neurosci. 18, 7-14 (2002). (Pubitemid 34252619)
    • (2002) Journal of Molecular Neuroscience , vol.18 , Issue.1-2 , pp. 7-14
    • Kastin, A.J.1    Akerstrom, V.2    Pan, W.3
  • 85
    • 0037349072 scopus 로고    scopus 로고
    • Entry of exendin-4 into brain is rapid but may be limited at high doses
    • DOI 10.1038/sj.ijo.0802206
    • Kastin, A. J. & Akerstrom, V. Entry of exendin-4 into brain is rapid but may be limited at high doses. Int. J. Obes. Relat. Metab. Disord. 27, 313-318 (2003). (Pubitemid 36384867)
    • (2003) International Journal of Obesity , vol.27 , Issue.3 , pp. 313-318
    • Kastin, A.J.1    Akerstrom, V.2
  • 86
    • 84868375789 scopus 로고    scopus 로고
    • Liraglutide a novel GLP-1 analogue, prevents the impairment of learning and LTP in an APP/PS-1 mouse model of Alzheimer's disease
    • Session 556.11, Poster K20 (Society for San Diego, California
    • McClean, P., Pathasarthy, V., Faivre, E. & Hφlscher, C. Liraglutide, a novel GLP-1 analogue, prevents the impairment of learning and LTP in an APP/PS-1 mouse model of Alzheimer's disease. Session 556.11, Poster K20 (Society for Neuroscience 40th Annual Meeting, San Diego, California; 2010).
    • (2010) Neuroscience 40th Annual Meeting
    • McClean, P.1    Pathasarthy, V.2    Faivre, E.3    Hlscher, C.4
  • 87
    • 70350619609 scopus 로고    scopus 로고
    • Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study
    • Astrup, A. et al. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet 374, 1606-1616 (2009).
    • (2009) Lancet , vol.374 , pp. 1606-1616
    • Astrup, A.1
  • 88
    • 0035808264 scopus 로고    scopus 로고
    • Anti-amyloidogenic activity of tetracyclines: Studies in vitro
    • DOI 10.1016/S0014-5793(00)02380-2, PII S0014579300023802
    • Forloni, G., Colombo, L., Girola, L., Tagliavini, F. & Salmona, M. Anti-amyloidogenic activity of tetracyclines: studies in vitro. FEBS Lett. 487, 404-407 (2001). (Pubitemid 32121764)
    • (2001) FEBS Letters , vol.487 , Issue.3 , pp. 404-407
    • Forloni, G.1    Colombo, L.2    Girola, L.3    Tagliavini, F.4    Salmona, M.5
  • 89
    • 6044273035 scopus 로고    scopus 로고
    • Minocycline inhibits neuronal death and glial activation induced by β-amyloid peptide in rat hippocampus
    • DOI 10.1002/glia.20051
    • Ryu, J. K., Franciosi, S., Sattayaprasert, P., Kim, S. U. & McLarnon, J. G. Minocycline inhibits neuronal death and glial activation induced by β-amyloid peptide in rat hippocampus. Glia 48, 85-90 (2004). (Pubitemid 39390851)
    • (2004) GLIA , vol.48 , Issue.1 , pp. 85-90
    • Ryu, J.K.1    Franciosi, S.2    Sattayaprasert, P.3    Kim, S.U.4    McLarnon, J.G.5
  • 90
    • 33947545098 scopus 로고    scopus 로고
    • Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid
    • DOI 10.1523/JNEUROSCI.4371-06.2007
    • Fan, R. et al. Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid. J. Neurosci. 27, 3057-3063 (2007). (Pubitemid 46474134)
    • (2007) Journal of Neuroscience , vol.27 , Issue.12 , pp. 3057-3063
    • Fan, R.1    Xu, F.2    Previti, M.L.3    Davis, J.4    Grande, A.M.5    Robinson, J.K.6    Van Nostrand, W.E.7
  • 91
    • 65949120942 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice
    • Garcia-Alloza, M. et al. Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice. J. Neurochem. 109, 1636-1647 (2009).
    • (2009) J. Neurochem , vol.109 , pp. 1636-1647
    • Garcia-Alloza, M.1
  • 92
    • 70349573768 scopus 로고    scopus 로고
    • Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding
    • Noble, W., Garwood, C. J. & Hanger, D. P. Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding. Prion 3, 78-83 (2009).
    • (2009) Prion , vol.3 , pp. 78-83
    • Noble, W.1    Garwood, C.J.2    Hanger, D.P.3
  • 93
    • 77957357526 scopus 로고    scopus 로고
    • Reductions in amyloid-β-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation
    • Parachikova, A., Vasilevko, V., Cribbs, D. H., LaFerla, F. M. & Green, K. N. Reductions in amyloid-β-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. J. Alzheimers Dis. 21, 527-542 (2010).
    • (2010) J. Alzheimers Dis , vol.21 , pp. 527-542
    • Parachikova, A.1    Vasilevko, V.2    Cribbs, D.H.3    Laferla, F.M.4    Green, K.N.5
  • 94
    • 79955941855 scopus 로고    scopus 로고
    • Increases in β-amyloid protein in the hippocampus caused by diabetic metabolic disorder are blocked by minocycline through inhibition of NF-κB pathway activation
    • Cai, Z. Y., Zhao, Y., Yao, S. T. & Zhao, B. Increases in β-amyloid protein in the hippocampus caused by diabetic metabolic disorder are blocked by minocycline through inhibition of NF-κB pathway activation. Pharmacol. Rep. 63, 381-391 (2011).
    • (2011) Pharmacol. Rep , vol.63 , pp. 381-391
    • Cai, Z.Y.1    Zhao, Y.2    Yao, S.T.3    Zhao, B.4
  • 95
    • 76749139924 scopus 로고    scopus 로고
    • Early-stage inflammation and experimental therapy in transgenic models of the Alzheimer-like amyloid pathology
    • Cuello, A. C. et al. Early-stage inflammation and experimental therapy in transgenic models of the Alzheimer-like amyloid pathology. Neurodegener. Dis. 7, 96-98 (2010).
    • (2010) Neurodegener. Dis , vol.7 , pp. 96-98
    • Cuello, A.C.1
  • 96
    • 33646243562 scopus 로고    scopus 로고
    • Minocycline affects microglia activation, Aβ deposition, and behavior in APP-tg mice
    • Seabrook, T. J., Jiang, L. Y., Maier, M. & Lemere, C. A. Minocycline affects microglia activation, Aβ deposition, and behavior in APP-tg mice. Glia 53, 776-782 (2006).
    • (2006) Glia , vol.53 , pp. 776-782
    • Seabrook, T.J.1    Jiang, L.Y.2    Maier, M.3    Lemere, C.A.4
  • 97
    • 62149143767 scopus 로고    scopus 로고
    • Minocycline reduces engraftment and activation of bone marrow-derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease
    • Malm, T. M. et al. Minocycline reduces engraftment and activation of bone marrow-derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease. Glia 56, 1767-1779 (2008).
    • (2008) Glia , vol.56 , pp. 1767-1779
    • Malm, T.M.1
  • 98
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • DOI 10.1096/fj.07-9574LSF
    • Reagan-Shaw, S., Nihal, M. & Ahmad, N. Dose translation from animal to human studies revisited. FASEB J. 22, 659-661 (2008). (Pubitemid 351348146)
    • (2008) FASEB Journal , vol.22 , Issue.3 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2    Ahmad, N.3
  • 100
    • 12244265476 scopus 로고    scopus 로고
    • Minocycline for Huntington's disease: An open label study
    • Bonelli, R. M., Heuberger, C. & Reisecker, F. Minocycline for Huntington's disease: an open label study. Neurology 60, 883-884 (2003). (Pubitemid 36297384)
    • (2003) Neurology , vol.60 , Issue.5 , pp. 883-884
    • Bonelli, R.M.1    Heuberger, C.2    Reisecker, F.3
  • 102
    • 4444233214 scopus 로고    scopus 로고
    • Minocycline in Huntington's disease: A pilot study
    • DOI 10.1002/mds.20018
    • Thomas, M., Ashizawa, T. & Jankovic, J. Minocycline in Huntington's disease: a pilot study. Mov. Disord. 19, 692-695 (2004). (Pubitemid 39173025)
    • (2004) Movement Disorders , vol.19 , Issue.6 , pp. 692-695
    • Thomas, M.1    Ashizawa, T.2    Jankovic, J.3
  • 103
    • 78649369122 scopus 로고    scopus 로고
    • A futility study of minocycline in Huntington's disease
    • Schwarz, H. et al. A futility study of minocycline in Huntington's disease. Mov. Disord. 25, 2219-2224 (2010).
    • (2010) Mov. Disord , vol.25 , pp. 2219-2224
    • Schwarz, H.1
  • 106
    • 4344628460 scopus 로고    scopus 로고
    • Disruption of the retinoid signalling pathway causes a deposition of amyloid β in the adult rat brain
    • DOI 10.1111/j.1460-9568.2004.03563.x
    • Corcoran, J. P. T., So, P. L. & Maden, M. Disruption of the retinoid signalling pathway causes a deposition of amyloid β in the adult rat brain. Eur. J. Neurosci. 20, 896-902 (2004). (Pubitemid 39141297)
    • (2004) European Journal of Neuroscience , vol.20 , Issue.4 , pp. 896-902
    • Corcoran, J.P.T.1    Po, L.S.2    Maden, M.3
  • 107
    • 33747132102 scopus 로고    scopus 로고
    • Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in β-amyloid deposits in the cerebral cortex of vitamin A deprived rats
    • DOI 10.1016/j.nbd.2006.01.008, PII S0969996106000143
    • Husson, M. et al. Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in β-amyloid deposits in the cerebral cortex of vitamin A deprived rats. Neurobiol. Dis. 23, 1-10 (2006). (Pubitemid 44218979)
    • (2006) Neurobiology of Disease , vol.23 , Issue.1 , pp. 1-10
    • Husson, M.1    Enderlin, V.2    Delacourte, A.3    Ghenimi, N.4    Alfos, S.5    Pallet, V.6    Higueret, P.7
  • 108
    • 58149268892 scopus 로고    scopus 로고
    • Retinoic acid attenuates β-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model
    • Ding, Y. et al. Retinoic acid attenuates β-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model. J. Neurosci. 28, 11622-11634 (2008).
    • (2008) J. Neurosci , vol.28 , pp. 11622-11634
    • Ding, Y.1
  • 109
    • 67649359888 scopus 로고    scopus 로고
    • Up-regulation of the α-secretase ADAM10 by retinoic acid receptors and acitretin
    • Tippmann, F., Hundt, J., Schneider, A., Endres, K. & Fahrenholz, F. Up-regulation of the α-secretase ADAM10 by retinoic acid receptors and acitretin. FASEB J. 23, 1643-1654 (2009).
    • (2009) FASEB J , vol.23 , pp. 1643-1654
    • Tippmann, F.1    Hundt, J.2    Schneider, A.3    Endres, K.4    Fahrenholz, F.5
  • 110
    • 77958480110 scopus 로고    scopus 로고
    • Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β
    • Jarvis, C. I. et al. Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β. Eur. J. Neurosci. 32, 1246-1255 (2010).
    • (2010) Eur. J. Neurosci , vol.32 , pp. 1246-1255
    • Jarvis, C.I.1
  • 111
    • 67650717654 scopus 로고    scopus 로고
    • Oral administration of synthetic retinoid am80 (tamibarotene) decreases brain β-amyloid peptides in APP23 mice
    • Kawahara, K. et al. Oral administration of synthetic retinoid am80 (tamibarotene) decreases brain β-amyloid peptides in APP23 mice. Biol. Pharm. Bull. 32, 1307-1309 (2009).
    • (2009) Biol. Pharm. Bull , vol.32 , pp. 1307-1309
    • Kawahara, K.1
  • 112
    • 84862777666 scopus 로고    scopus 로고
    • ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models
    • Cramer, P. E. et al. ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models. Science 335, 1503-1506 (2012).
    • (2012) Science , vol.335 , pp. 1503-1506
    • Cramer, P.E.1
  • 113
    • 79959772357 scopus 로고    scopus 로고
    • Human apoE isoforms differentially regulate brain amyloid-β peptide clearance
    • Castellano, J. M. et al. Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci. Transl. Med. 3, 89ra57 (2011).
    • (2011) Sci. Transl. Med , vol.3
    • Castellano, J.M.1
  • 115
    • 33748887415 scopus 로고    scopus 로고
    • Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth
    • So, P. L. et al. Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth. Dev. Biol. 298, 167-175 (2006).
    • (2006) Dev. Biol , vol.298 , pp. 167-175
    • So, P.L.1
  • 116
    • 58649112368 scopus 로고    scopus 로고
    • Sequential RARβ and α signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways
    • Goncalves, M. et al. Sequential RARβ and α signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways. Dev. Biol. 326, 305-313 (2009).
    • (2009) Dev. Biol , vol.326 , pp. 305-313
    • Goncalves, M.1
  • 117
    • 70849097441 scopus 로고    scopus 로고
    • All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease
    • Lee, H. P. et al. All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease. Expert Rev Neurother. 9, 1615-1621(2009).
    • (2009) Expert Rev Neurother , vol.9 , pp. 1615-1621
    • Lee, H.P.1
  • 119
    • 0028085028 scopus 로고
    • Kinetics of tissue distribution and elimination of retinoid drugs in the rat. I. Acitretin
    • Eisenhardt, E. U. & Bickel, M. H. Kinetics of tissue distribution and elimination of retinoid drugs in the rat. I. Acitretin. Drug Metab. Dispos. 22, 26-30 (1994). (Pubitemid 24045375)
    • (1994) Drug Metabolism and Disposition , vol.22 , Issue.1 , pp. 26-30
    • Eisenhardt, E.U.1    Bickel, M.H.2
  • 120
    • 0037713314 scopus 로고    scopus 로고
    • Persistence of cognitive impairment in geriatric patients following antidepressant treatment: A randomized, double-blind clinical trial with nortriptyline and paroxetine
    • DOI 10.1016/S0022-3956(02)00085-7, PII S0022395602000857
    • Nebes, R. D. et al. Persistence of cognitive impairment in geriatric patients following antidepressant treatment: a randomized, double-blind clinical trial with nortriptyline and paroxetine. J. Psychiatr. Res. 37, 99-108 (2003). (Pubitemid 36808472)
    • (2003) Journal of Psychiatric Research , vol.37 , Issue.2 , pp. 99-108
    • Nebes, R.D.1    Pollock, B.G.2    Houck, P.R.3    Butters, M.A.4    Mulsant, B.H.5    Zmuda, M.D.6    Reynolds III, C.F.7
  • 121
    • 43049129922 scopus 로고    scopus 로고
    • An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers
    • Scholey, A. B. et al. An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers. Psychopharmacology 198, 127-139 (2008).
    • (2008) Psychopharmacology , vol.198 , pp. 127-139
    • Scholey, A.B.1
  • 122
    • 74949089743 scopus 로고    scopus 로고
    • Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia
    • McGuinness, B., Todd, S., Passmore, P. & Bullock, R. Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia. Cochrane Database Syst. Rev. 2009, CD004034 (2009).
    • (2009) Cochrane Database Syst. Rev , vol.2009
    • McGuinness, B.1    Todd, S.2    Passmore, P.3    Bullock, R.4
  • 123
    • 78149245073 scopus 로고    scopus 로고
    • Role of inflammation in cognitive impairment: Results of observational epidemiological studies and clinical trials
    • Gorelick, P. B. Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials. Ann. NY Acad. Sci. 1207, 155-162 (2010).
    • (2010) Ann. NY Acad. Sci , vol.1207 , pp. 155-162
    • Gorelick, P.B.1
  • 124
    • 84861314593 scopus 로고    scopus 로고
    • Steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease
    • Jaturapatporn, D., Isaac, M., McCleery, J. & Tabet, N. Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease. Cochrane Database Syst. Rev. 2012, CD006378 (2012).
    • (2012) Cochrane Database Syst. Rev , vol.2012
    • Jaturapatporn, D.1    Isaac, M.2    McCleery, J.3    Aspirin, T.N.4
  • 125
    • 70349570588 scopus 로고    scopus 로고
    • Systemic inflammation and disease progression in Alzheimer disease
    • Holmes, C. et al. Systemic inflammation and disease progression in Alzheimer disease. Neurology 73, 768-774 (2009).
    • (2009) Neurology , vol.73 , pp. 768-774
    • Holmes, C.1
  • 126
    • 77954623308 scopus 로고    scopus 로고
    • Improvement of cognition, a potential benefit of anti-TNF therapy in elderly patients with rheumatoid arthritis
    • Chen, Y. M., Chen, H. H., Lan, J. L. & Chen, D. Y. Improvement of cognition, a potential benefit of anti-TNF therapy in elderly patients with rheumatoid arthritis. Joint Bone Spine 77, 366-367 (2010).
    • (2010) Joint Bone Spine , vol.77 , pp. 366-367
    • Chen, Y.M.1    Chen, H.H.2    Lan, J.L.3    Chen, D.Y.4
  • 127
    • 77958567930 scopus 로고    scopus 로고
    • Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: A randomized controlled trial
    • Smith, A. D. et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS ONE 5, e12244 (2010).
    • (2010) PLoS ONE , vol.5
    • Smith, A.D.1
  • 129
    • 58449130099 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques
    • Wozniak, M. A., Mee, A. P. & Itzhaki, R. F. Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques. J. Pathol. 217, 131-138 (2009).
    • (2009) J. Pathol , vol.217 , pp. 131-138
    • Wozniak, M.A.1    Mee, A.P.2    Itzhaki, R.F.3
  • 130
    • 47849119723 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 in Alzheimer's disease: The enemy within
    • Itzhaki, R. F. & Wozniak, M. A. Herpes simplex virus type 1 in Alzheimer's disease: the enemy within. J. Alzheimers Dis. 13, 393-405 (2008). (Pubitemid 352039023)
    • (2008) Journal of Alzheimer's Disease , vol.13 , Issue.4 , pp. 393-405
    • Itzhaki, R.F.1    Wozniak, M.A.2
  • 131
    • 48249096759 scopus 로고    scopus 로고
    • A feasibility and tolerability study of lithium in Alzheimer's disease
    • Macdonald, A. et al. A feasibility and tolerability study of lithium in Alzheimer's disease. Int. J. Geriatr. Psychiatry 23, 704-711 (2008).
    • (2008) Int. J. Geriatr. Psychiatry , vol.23 , pp. 704-711
    • MacDonald, A.1
  • 132
    • 67649206084 scopus 로고    scopus 로고
    • Lithium trial in Alzheimer's disease: A randomized, single-blind, placebo-controlled, multicenter 10-week study
    • Hampel, H. et al. Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study. J. Clin. Psychiatry 70, 922-931 (2009).
    • (2009) J. Clin. Psychiatry , vol.70 , pp. 922-931
    • Hampel, H.1
  • 133
    • 70349638299 scopus 로고    scopus 로고
    • Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies
    • Brunden, K. R., Trojanowski, J. Q. & Lee, V. M. Y. Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. Nature Rev. Drug Discov. 8, 783-793 (2009).
    • (2009) Nature Rev. Drug Discov , vol.8 , pp. 783-793
    • Brunden, K.R.1    Trojanowski, J.Q.2    Lee, V.M.Y.3
  • 134
    • 79952439187 scopus 로고    scopus 로고
    • Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes
    • Gupta, A., Bisht, B. & Dey, C. S. Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes. Neuropharmacology 60, 910-920 (2011).
    • (2011) Neuropharmacology , vol.60 , pp. 910-920
    • Gupta, A.1    Bisht, B.2    Dey, C.S.3
  • 135
    • 79956277464 scopus 로고    scopus 로고
    • Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin
    • Hsu, C. C., Wahlqvist, M. L., Lee, M. S. & Tsai, H. N. Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin. J. Alzheimers Dis. 24, 485-493 (2011).
    • (2011) J. Alzheimers Dis , vol.24 , pp. 485-493
    • Hsu, C.C.1    Wahlqvist, M.L.2    Lee, M.S.3    Tsai, H.N.4
  • 137
    • 82255160648 scopus 로고    scopus 로고
    • Chronic divalproex sodium use and brain atrophy in Alzheimer disease
    • Fleisher, A. S. et al. Chronic divalproex sodium use and brain atrophy in Alzheimer disease. Neurology 77, 1263-1271 (2011).
    • (2011) Neurology , vol.77 , pp. 1263-1271
    • Fleisher, A.S.1
  • 138
    • 77956090575 scopus 로고    scopus 로고
    • Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: Results from a randomized, double-blind, placebo-controlled Phase III study
    • Gold, M. et al. Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled Phase III study. Dementia Geriatr. Cognitive Disord. 30, 131-146 (2010).
    • (2010) Dementia Geriatr. Cognitive Disord , vol.30 , pp. 131-146
    • Gold, M.1
  • 139
    • 79959479102 scopus 로고    scopus 로고
    • Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer's disease
    • Sato T. et al. Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer's disease. Neurobiol. Aging 32, 1626-1633 (2011).
    • (2011) Neurobiol. Aging , vol.32 , pp. 1626-1633
    • Sato, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.