-
2
-
-
80052266213
-
The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics
-
Karran, E., Mercken, M. & De Strooper, B. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nature Rev. Drug Discov. 10, 698-712 (2011).
-
(2011)
Nature Rev. Drug Discov
, vol.10
, pp. 698-712
-
-
Karran, E.1
Mercken, M.2
De Strooper, B.3
-
3
-
-
77955322042
-
Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models
-
Ittner, L. M. et al. Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models. Cell 142, 387-397 (2010).
-
(2010)
Cell
, vol.142
, pp. 387-397
-
-
Ittner, L.M.1
-
4
-
-
79952747862
-
Alzheimer's disease
-
Ballard, C. et al. Alzheimer's disease. Lancet 377, 1019-1031 (2011).
-
(2011)
Lancet
, vol.377
, pp. 1019-1031
-
-
Ballard, C.1
-
5
-
-
79952666442
-
Aligning the evidence with practice: NICE guidelines for drug treatment of Alzheimer's disease
-
Ballard, C., Corbett, A. & Sharp, S. Aligning the evidence with practice: NICE guidelines for drug treatment of Alzheimer's disease. Expert Rev. Neurother. 11, 327-329 (2011).
-
(2011)
Expert Rev. Neurother
, vol.11
, pp. 327-329
-
-
Ballard, C.1
Corbett, A.2
Sharp, S.3
-
6
-
-
43249122280
-
Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: A randomised phase II trial
-
Wilcock, G. K. et al. Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial. Lancet Neurol. 7, 483-493 (2008).
-
(2008)
Lancet Neurol
, vol.7
, pp. 483-493
-
-
Wilcock, G.K.1
-
7
-
-
72549105935
-
Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: A randomized controlled trial
-
Green, R. C. et al. Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial. JAMA 302, 2557-2564 (2009).
-
(2009)
JAMA
, vol.302
, pp. 2557-2564
-
-
Green, R.C.1
-
8
-
-
77956214193
-
Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death
-
Zhang, S. T., Hedskog, L., Petersen, C. A. H., Winblad, B. & Ankarcrona, M. Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death. J. Alzheimers Dis. 21, 389-402 (2010).
-
(2010)
J. Alzheimers Dis
, vol.21
, pp. 389-402
-
-
Zhang, S.T.1
Hedskog, L.2
Petersen, C.A.H.3
Winblad, B.4
Ankarcrona, M.5
-
9
-
-
84855414394
-
Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease
-
D'Onofrio, G. et al. Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease. Expert Opin. Drug Discov. 7, 19-37 (2012).
-
(2012)
Expert Opin. Drug Discov
, vol.7
, pp. 19-37
-
-
D'Onofrio, G.1
-
10
-
-
0033536163
-
Immunization with amyloid-β attenuates Alzheimer disease-like pathology in the PDAPP mouse
-
DOI 10.1038/22124
-
Schenk, D. et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173-177 (1999). (Pubitemid 29327547)
-
(1999)
Nature
, vol.400
, Issue.6740
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guldo, T.6
Hu, K.7
Huang, J.8
Johnson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Motter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandevert, C.20
Walker, S.21
Wogulis, M.22
Yednock, T.23
Games, D.24
Seubert, P.25
more..
-
11
-
-
47149112621
-
42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase I trial
-
DOI 10.1016/S0140-6736(08)61075-2, PII S0140673608610752
-
Holmes, C. et al. Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 372, 216-223 (2008). (Pubitemid 351978111)
-
(2008)
The Lancet
, vol.372
, Issue.9634
, pp. 216-223
-
-
Holmes, C.1
Boche, D.2
Wilkinson, D.3
Yadegarfar, G.4
Hopkins, V.5
Bayer, A.6
Jones, R.W.7
Bullock, R.8
Love, S.9
Neal, J.W.10
Zotova, E.11
Nicoll, J.A.12
-
12
-
-
63149148789
-
Intracerebroventricular amyloid-β antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice
-
Thakker, D. R. et al. Intracerebroventricular amyloid-β antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc. Natl Acad. Sci. USA 106, 4501-4506 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 4501-4506
-
-
Thakker, D.R.1
-
13
-
-
73349091534
-
A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
-
Salloway, S. et al. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology 73, 2061-2070 (2009).
-
(2009)
Neurology
, vol.73
, pp. 2061-2070
-
-
Salloway, S.1
-
14
-
-
34447322271
-
Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria
-
DOI 10.1016/S1474-4422(07)70178-3, PII S1474442207701783
-
Dubois, B. et al. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 6, 734-746 (2007). (Pubitemid 47058377)
-
(2007)
Lancet Neurology
, vol.6
, Issue.8
, pp. 734-746
-
-
Dubois, B.1
Feldman, H.H.2
Jacova, C.3
DeKosky, S.T.4
Barberger-Gateau, P.5
Cummings, J.6
Delacourte, A.7
Galasko, D.8
Gauthier, S.9
Jicha, G.10
Meguro, K.11
O'Brien, J.12
Pasquier, F.13
Robert, P.14
Rossor, M.15
Salloway, S.16
Stern, Y.17
Visser, P.J.18
Scheltens, P.19
-
15
-
-
77953518555
-
Alzheimer's disease: Clinical trials and drug development
-
Mangialasche, F., Solomon, A., Winblad, B., Mecocci, P. & Kivipelto, M. Alzheimer's disease: clinical trials and drug development. Lancet Neurol. 9, 702-716 (2010).
-
(2010)
Lancet Neurol
, vol.9
, pp. 702-716
-
-
Mangialasche, F.1
Solomon, A.2
Winblad, B.3
Mecocci, P.4
Kivipelto, M.5
-
16
-
-
84867338003
-
Discovery and preclinical validation of drug indications using compendia of public gene expression data
-
Sirota, M. et al. Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci. Transl. Med. 3, 96ra77 (2011).
-
(2011)
Sci. Transl. Med
, vol.3
-
-
Sirota, M.1
-
17
-
-
4344668661
-
Drug repositioning: Identifying and developing new uses for existing drugs
-
Ashburn, T. T. & Thor, K. B. Drug repositioning: Identifying and developing new uses for existing drugs. Nature Rev. Drug Discov. 3, 673-683 (2004). (Pubitemid 39173508)
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, Issue.8
, pp. 673-683
-
-
Ashburn, T.T.1
Thor, K.B.2
-
18
-
-
84860746711
-
Amantadine: The journey from fighting flu to treating Parkinson disease
-
Hubsher, G., Haider, M. & Okun, M. S. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology 78, 1096-1099 (2012).
-
(2012)
Neurology
, vol.78
, pp. 1096-1099
-
-
Hubsher, G.1
Haider, M.2
Okun, M.S.3
-
19
-
-
0029012763
-
Incidence and risk-factors of vascular dementia and Alzheimers-disease in a defined elderly japanese population-the Hisayama study
-
Yoshitake, T. et al. Incidence and risk-factors of vascular dementia and Alzheimers-disease in a defined elderly japanese population-the Hisayama study. Neurology 45, 1161-1168 (1995).
-
(1995)
Neurology
, vol.45
, pp. 1161-1168
-
-
Yoshitake, T.1
-
20
-
-
0030003819
-
15-year longitudinal study of blood pressure and dementia
-
Skoog, I. et al. 15-year longitudinal study of blood pressure and dementia. Lancet 347, 1141-1145 (1996). (Pubitemid 126512042)
-
(1996)
Lancet
, vol.347
, Issue.9009
, pp. 1141-1145
-
-
Skoog, I.1
Lernfelt, B.2
Landahl, S.3
Palmertz, B.4
Andreasson, L.-A.5
Nilsson, L.6
Persson, G.7
Oden, A.8
Svanborg, A.9
-
21
-
-
0034594441
-
Midlife blood pressure and dementia: The Honolulu-Asia aging study
-
DOI 10.1016/S0197-4580(00)00096-8, PII S0197458000000968
-
Launer, L. J. et al. Midlife blood pressure and dementia: the Honolulu-Asia aging study. Neurobiol. Aging 21, 49-55 (2000). (Pubitemid 30224785)
-
(2000)
Neurobiology of Aging
, vol.21
, Issue.1
, pp. 49-55
-
-
Launer, L.J.1
Ross, G.W.2
Petrovitch, H.3
Masaki, K.4
Foley, D.5
White, L.R.6
Havlik, R.J.7
-
22
-
-
0037161304
-
The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function
-
Posner, H. B. et al. The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function. Neurology 58, 1175-1181 (2002). (Pubitemid 34411860)
-
(2002)
Neurology
, vol.58
, Issue.8
, pp. 1175-1181
-
-
Posner, H.B.1
Tang, M.-X.2
Luchsinger, J.3
Lantigua, R.4
Stern, Y.5
Mayeux, R.6
-
23
-
-
22144451172
-
The age-dependent relation of blood pressure to cognitive function and dementia
-
DOI 10.1016/S1474-4422(05)70141-1, PII S1474442205701411
-
Qiu, C., Winblad, B. & Fratiglioni, L. The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol. 4, 487-499 (2005). (Pubitemid 40982459)
-
(2005)
Lancet Neurology
, vol.4
, Issue.8
, pp. 487-499
-
-
Qiu, C.1
Winblad, B.2
Fratiglioni, L.3
-
24
-
-
75649144979
-
Role of vascular risk factors and vascular dysfunction in Alzheimer's disease
-
Dickstein, D. L. et al. Role of vascular risk factors and vascular dysfunction in Alzheimer's disease. Mt Sinai J. Med. 77, 82-102 (2010).
-
(2010)
Mt Sinai J. Med
, vol.77
, pp. 82-102
-
-
Dickstein, D.L.1
-
25
-
-
0031054674
-
Brain infarction and the clinical expression of Alzheimer disease: The Nun Study
-
Snowdon, D. A. et al. Brain infarction and the clinical expression of Alzheimer disease-the nun study. JAMA 277, 813-817 (1997). (Pubitemid 27111317)
-
(1997)
Journal of the American Medical Association
, vol.277
, Issue.10
, pp. 813-817
-
-
Snowdon, D.A.1
Greiner, L.H.2
Mortimer, J.A.3
Riley, K.P.4
Greiner, P.A.5
Markesbery, W.R.6
-
26
-
-
70450045976
-
Angiotensins in Alzheimer's disease-friend or foe?
-
Kehoe, P. G., Miners, J. S. & Love, S. Angiotensins in Alzheimer's disease-friend or foe? Trends Neurosci. 32, 619-628 (1997).
-
(1997)
Trends Neurosci
, vol.32
, pp. 619-628
-
-
Kehoe, P.G.1
Miners, J.S.2
Love, S.3
-
27
-
-
84860112460
-
The renin-angiotensin system and antihypertensive drugs in Alzheimer's disease: Current standing of the angiotensin hypothesis?
-
Kehoe, P. G. & Passmore, P. A. The renin-angiotensin system and antihypertensive drugs in Alzheimer's disease: current standing of the angiotensin hypothesis? J. Alzheimers Dis. 30, S251-S269 (2012).
-
(2012)
J. Alzheimers Dis
, vol.30
-
-
Kehoe, P.G.1
Passmore, P.A.2
-
28
-
-
79960675107
-
Brain renin-angiotensin-a new look at an old system
-
Wright, J. W. & Harding, J. W. Brain renin-angiotensin-a new look at an old system. Prog. Neurobiol. 95, 49-67 (2011).
-
(2011)
Prog. Neurobiol
, vol.95
, pp. 49-67
-
-
Wright, J.W.1
Harding, J.W.2
-
29
-
-
0036672123
-
1-receptor blockers
-
Culman, J., Blume, A., Gohlke, P. & Unger, T. The renin-angiotensin system in the brain: possible therapeutic implications for AT1-receptor blockers. J. Hum. Hypertens. 16, S64-S70 (2002). (Pubitemid 35021380)
-
(2002)
Journal of Human Hypertension
, vol.16
, Issue.SUPPL. 3
-
-
Culman, J.1
Blume, A.2
Gohlke, P.3
Unger, T.4
-
30
-
-
36049002393
-
Valsartan lowers brain β-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease
-
DOI 10.1172/JCI31547
-
Wang, J. et al. Valsartan lowers brain β-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease. J. Clin. Invest. 117, 3393-3402 (2007). (Pubitemid 350096995)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.11
, pp. 3393-3402
-
-
Wang, J.1
Ho, L.2
Chen, L.3
Zhao, Z.4
Zhao, W.5
Qian, X.6
Humala, N.7
Seror, I.8
Bartholomew, S.9
Rosendorff, C.10
Pasinetti, G.M.11
-
31
-
-
79952977933
-
Angiotensin II-inhibiting drugs have no effect on intraneuronal Aβ or oligomeric Aβ levels in a triple transgenic mouse model of Alzheimer's disease
-
Ferrington, L. et al. Angiotensin II-inhibiting drugs have no effect on intraneuronal Aβ or oligomeric Aβ levels in a triple transgenic mouse model of Alzheimer's disease. Am. J. Transl. Res. 3, 197-208 (2011).
-
(2011)
Am. J. Transl. Res
, vol.3
, pp. 197-208
-
-
Ferrington, L.1
-
32
-
-
33947245344
-
Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid β-protein metabolism in mouse models of Alzheimer disease
-
DOI 10.1016/j.nbd.2007.01.004, PII S096999610700023X
-
Hemming, M. L., Selkoe, D. J. & Farris, W. Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid β-protein metabolism in mouse models of Alzheimer disease. Neurobiol. Dis. 26, 273-281 (2007). (Pubitemid 46436503)
-
(2007)
Neurobiology of Disease
, vol.26
, Issue.1
, pp. 273-281
-
-
Hemming, M.L.1
Selkoe, D.J.2
Farris, W.3
-
33
-
-
73349097900
-
Angiotensin receptor blocker prevented β-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling
-
Takeda, S. et al. Angiotensin receptor blocker prevented β-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling. Hypertension 54, 1345-1352 (2009).
-
(2009)
Hypertension
, vol.54
, pp. 1345-1352
-
-
Takeda, S.1
-
34
-
-
50849089332
-
Telmisartan prevented cognitive decline partly due to PPAR-γ activation
-
Mogi, M. et al. Telmisartan prevented cognitive decline partly due to PPAR-γ activation. Biochem. Biophys. Res. Commun. 375, 446-449 (2008).
-
(2008)
Biochem. Biophys. Res. Commun
, vol.375
, pp. 446-449
-
-
Mogi, M.1
-
35
-
-
77952342062
-
Protective effects of intranasal losartan in the APP/PS1 transgenic mouse model of Alzheimer disease
-
Danielyan, L. et al. Protective effects of intranasal losartan in the APP/PS1 transgenic mouse model of Alzheimer disease. Rejuven. Res. 13, 195-201 (2010).
-
(2010)
Rejuven. Res
, vol.13
, pp. 195-201
-
-
Danielyan, L.1
-
36
-
-
74949131237
-
Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: Prospective cohort analysis
-
Li, N.-C. et al. Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis. BMJ 340, b5465 (2010).
-
(2010)
BMJ
, vol.340
-
-
Li, N.-C.1
-
37
-
-
80054843547
-
Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias
-
Davies, N. M., Kehoe, P. G., Ben-Shlomo, Y. & Martin, R. M. Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias. J. Alzheimers Dis. 26, 699-708 (2011).
-
(2011)
J. Alzheimers Dis
, vol.26
, pp. 699-708
-
-
Davies, N.M.1
Kehoe, P.G.2
Ben-Shlomo, Y.3
Martin, R.M.4
-
38
-
-
78650022206
-
Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: Analysis of data from the ONTARGET and TRANSCEND studies
-
Anderson, C. et al. Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies. Lancet Neurol. 10, 43-53 (2011).
-
(2011)
Lancet Neurol
, vol.10
, pp. 43-53
-
-
Anderson, C.1
-
39
-
-
0037534905
-
The study on cognition and prognosis in the elderly (SCOPE): Principal results of a randomized double-blind intervention trial
-
DOI 10.1097/00004872-200305000-00011
-
Lithell, H. et al. The study on cognition and prognosis in the elderly (SCOPE): principal results of a randomized double-blind intervention trial. J. Hypertens. 21, 875-886 (2003). (Pubitemid 36677151)
-
(2003)
Journal of Hypertension
, vol.21
, Issue.5
, pp. 875-886
-
-
Lithell, H.1
Hansson, L.2
Skoog, I.3
Elmfeldt, D.4
Hofman, A.5
Olofsson, B.6
Trenkwalder, P.7
Zanchetti, A.8
-
40
-
-
23744468024
-
Effect of baseline cognitive function and antihypertensive treatment on cognitive and cardiovascular outcomes: Study on COgnition and Prognosis in the Elderly (SCOPE)
-
DOI 10.1016/j.amjhyper.2005.02.013, PII S0895706105001020
-
Skoog, I. et al. Effect of baseline cognitive function and anti hypertensive treatment on cognitive and cardiovascular outcomes: study on cognition and prognosis in the elderly (SCOPE). Am. J. Hypertens. 18, 1052-1059 (2005). (Pubitemid 41139903)
-
(2005)
American Journal of Hypertension
, vol.18
, Issue.8
, pp. 1052-1059
-
-
Skoog, I.1
Lithell, H.2
Hansson, L.3
Elmfeldt, D.4
Hofman, A.5
Olofsson, B.6
Trenkwalder, P.7
Zanchetti, A.8
-
41
-
-
0028911939
-
Nitrendipine and mefruside in elderly hypertensives-effects on blood-pressure, cardiac-output, cerebral blood-flow and metabolic parameters
-
Landmark, K. et al. Nitrendipine and mefruside in elderly hypertensives-effects on blood-pressure, cardiac-output, cerebral blood-flow and metabolic parameters. J. Hum. Hypertens. 9, 281-285 (1995).
-
(1995)
J. Hum. Hypertens
, vol.9
, pp. 281-285
-
-
Landmark, K.1
-
42
-
-
34247566711
-
Favourable effects of nilvadipine on cognitive function and regional cerebral blood flow on SPECT in hypertensive patients with mild cognitive impairment
-
DOI 10.1097/MNM.0b013e32804c58aa, PII 0000623120070400000009
-
Hanyu, H. et al. Favourable effects of nilvadipine on cognitive function and regional cerebral blood flow on SPECT in hypertensive patients with mild cognitive impairment. Nuclear Med. Commun. 28, 281-287 (2007). (Pubitemid 46673205)
-
(2007)
Nuclear Medicine Communications
, vol.28
, Issue.4
, pp. 281-287
-
-
Hanyu, H.1
Hirao, K.2
Shimizu, S.3
Iwamoto, T.4
Koizumi, K.5
Abe, K.6
-
43
-
-
0025053422
-
Effects of nimodipine on cerebral blood flow and neuropsychological outcome after cardiac surgery
-
Forsman, M., Olsnes, B. T., Semb, G. & Steen, P. A. Effects of nimodipine on cerebral blood flow and neuropsychological outcome after cardiac surgery. Br. J. Anaesth. 65, 514-520 (1990). (Pubitemid 20337999)
-
(1990)
British Journal of Anaesthesia
, vol.65
, Issue.4
, pp. 514-520
-
-
Forsman, M.1
Tubylewicz Olsnes, B.2
Semb, G.3
Steen, P.A.4
-
44
-
-
58849148507
-
Identification of antihypertensive drugs which inhibit amyloid-β protein oligomerization
-
Zhao, W. et al. Identification of antihypertensive drugs which inhibit amyloid-β protein oligomerization. J. Alzheimers Dis. 16, 49-57 (2009).
-
(2009)
J. Alzheimers Dis
, vol.16
, pp. 49-57
-
-
Zhao, W.1
-
45
-
-
79955941709
-
Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier
-
Bachmeier, C., Beaulieu-Abdelahad, D., Mullan, M. & Paris, D. Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier. Eur. J. Pharmacol. 659, 124-129 (2011).
-
(2011)
Eur. J. Pharmacol
, vol.659
, pp. 124-129
-
-
Bachmeier, C.1
Beaulieu-Abdelahad, D.2
Mullan, M.3
Paris, D.4
-
46
-
-
78349309295
-
L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease
-
Anekonda, T. S. et al. L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease. Neurobiol. Dis. 41, 62-70 (2011).
-
(2011)
Neurobiol. Dis
, vol.41
, pp. 62-70
-
-
Anekonda, T.S.1
-
47
-
-
34247230363
-
2 against glutamate-induced neurotoxicity in PC12 cells
-
DOI 10.1016/j.jep.2006.12.015, PII S0378874106006611
-
Li, N., Liu, B., Dluzen, D. E. & Jin, Y. Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells. J. Ethnopharmacol. 111, 458-463 (2007). (Pubitemid 46617084)
-
(2007)
Journal of Ethnopharmacology
, vol.111
, Issue.3
, pp. 458-463
-
-
Li, N.1
Liu, B.2
Dluzen, D.E.3
Jin, Y.4
-
48
-
-
79952860789
-
Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier
-
Paris, D. et al. Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier. Mol. Med. 17, 149-162 (2011).
-
(2011)
Mol. Med
, vol.17
, pp. 149-162
-
-
Paris, D.1
-
49
-
-
34147128293
-
Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with β-amyloid in rats
-
DOI 10.1248/bpb.30.698
-
Iwasaki, K. et al. Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with β-amyloid in rats. Biol. Pharm. Bull. 30, 698-701 (2007). (Pubitemid 46570991)
-
(2007)
Biological and Pharmaceutical Bulletin
, vol.30
, Issue.4
, pp. 698-701
-
-
Iwasaki, K.1
Egashira, N.2
Takagaki, Y.3
Yoshimitsu, Y.4
Hatip-Al-Khatib, I.5
Mishima, K.6
Fujiwara, M.7
-
50
-
-
80052288667
-
A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: Isradipine as a candidate drug
-
Copenhaver, P. F. et al. A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug. Dis. Model. Mech. 4, 634-648 (2011).
-
(2011)
Dis. Model. Mech
, vol.4
, pp. 634-648
-
-
Copenhaver, P.F.1
-
51
-
-
0036046464
-
Nimodipine for primary degenerative, mixed and vascular dementia
-
Lopez-Arrieta, J. M. & Birks, J. Nimodipine for primary degenerative, mixed and vascular dementia. Cochrane Database Syst. Rev. 2002, CD000147 (2002).
-
(2002)
Cochrane Database Syst. Rev
, vol.2002
-
-
Lopez-Arrieta, J.M.1
Birks, J.2
-
52
-
-
0026718552
-
Blocking the Ca2+-activated cytotoxic mechanisms of cholinergic neuronal death: A novel treatment strategy for Alzheimer's disease
-
Branconnier, R. J., Branconnier, M. E., Walshe, T. M., McCarthy, C. & Morse, P. A. Blocking the Ca2+-activated cytotoxic mechanisms of cholinergic neuronal death: a novel treatment strategy for Alzheimer's disease. Psychopharmacol. Bull. 28, 175-181 (1992).
-
(1992)
Psychopharmacol. Bull
, vol.28
, pp. 175-181
-
-
Branconnier, R.J.1
Branconnier, M.E.2
Walshe, T.M.3
McCarthy, C.4
Morse, P.A.5
-
53
-
-
0030009517
-
Nimodipine in the treatment of probable Alzheimer's disease-results of two multicentre trials
-
Morich, F. J. et al. Nimodipine in the treatment of probable Alzheimer's disease-results of two multicentre trials. Clin. Drug Invest. 11, 185-195 (1996).
-
(1996)
Clin. Drug Invest
, vol.11
, pp. 185-195
-
-
Morich, F.J.1
-
54
-
-
80052706430
-
Demonstration of safety in Alzheimer's patients for intervention with an anti-hypertensive drug nilvadipine: Results from a 6-week open label study
-
Kennelly, S. P. et al. Demonstration of safety in Alzheimer's patients for intervention with an anti-hypertensive drug nilvadipine: results from a 6-week open label study. Int. J. Geriatr. Psychiatry 26, 1038-1045 (2011).
-
(2011)
Int. J. Geriatr. Psychiatry
, vol.26
, pp. 1038-1045
-
-
Kennelly, S.P.1
-
55
-
-
84858339480
-
Apolipoprotein e genotype-specific short-term cognitive benefits of treatment with the antihypertensive nilvadipine in Alzheimer's patients-an open-label trial
-
Kennelly, S. et al. Apolipoprotein E genotype-specific short-term cognitive benefits of treatment with the antihypertensive nilvadipine in Alzheimer's patients-an open-label trial. Int. J. Geriatr. Psychiatry 27, 415-422 (2012).
-
(2012)
Int. J. Geriatr. Psychiatry
, vol.27
, pp. 415-422
-
-
Kennelly, S.1
-
56
-
-
33646433026
-
Antihypertensive medication use and incident Alzheimer disease-the Cache County study
-
Khachaturian, A. S. et al. Antihypertensive medication use and incident Alzheimer disease-the Cache County study. Arch. Neurol. 63, 686-692 (2006).
-
(2006)
Arch. Neurol
, vol.63
, pp. 686-692
-
-
Khachaturian, A.S.1
-
57
-
-
0037078312
-
The prevention of dementia with antihypertensive treatment
-
Forette, F. et al. The prevention of dementia with antihypertensive treatment. Arch. Intern. Med. 162, 2046-2052 (2002).
-
(2002)
Arch. Intern. Med
, vol.162
, pp. 2046-2052
-
-
Forette, F.1
-
58
-
-
78650029989
-
Insulin metabolism and the risk of Alzheimer disease-the Rotterdam study
-
Schrijvers, E. M. C. et al. Insulin metabolism and the risk of Alzheimer disease-the Rotterdam study. Neurology 75, 1982-1987 (2010).
-
(2010)
Neurology
, vol.75
, pp. 1982-1987
-
-
Schrijvers, E.M.C.1
-
59
-
-
71349085957
-
Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
-
Moloney, A. M. et al. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol. Aging 31, 224-243 (2010).
-
(2010)
Neurobiol. Aging
, vol.31
, pp. 224-243
-
-
Moloney, A.M.1
-
60
-
-
6344250713
-
Insulin and the CNS: Effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans
-
DOI 10.1016/j.physbeh.2004.07.022, PII S0031938404003488
-
Stockhorst, U., de Fries, D., Steingrueber, H. J. & Scherbaum, W. A. Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans. Physiol. Behav. 83, 47-54 (2004). (Pubitemid 39387693)
-
(2004)
Physiology and Behavior
, vol.83
, Issue.1 SPEC. ISS.
, pp. 47-54
-
-
Stockhorst, U.1
De Fries, D.2
Steingrueber, H.-J.3
Scherbaum, W.A.4
-
61
-
-
27844498075
-
Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies
-
Holscher, C. Development of β-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies. Rev. Neurosci. 16, 181-212 (2005). (Pubitemid 41655771)
-
(2005)
Reviews in the Neurosciences
, vol.16
, Issue.3
, pp. 181-212
-
-
Holscher, C.1
-
62
-
-
1842785179
-
Glucose metabolism and insulin receptor signal transduction in Alzheimer disease
-
DOI 10.1016/j.ejphar.2004.02.049, PII S0014299904002067
-
Hoyer, S. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. Eur. J. Pharmacol. 490, 115-125 (2004). (Pubitemid 38482165)
-
(2004)
European Journal of Pharmacology
, vol.490
, Issue.1-3
, pp. 115-125
-
-
Hoyer, S.1
-
63
-
-
36448936053
-
Common pathological processes in Alzheimer disease and type 2 diabetes: A review
-
DOI 10.1016/j.brainresrev.2007.09.001, PII S0165017307001907
-
Li, L. & Hlscher, C. Common pathological processes in Alzheimer disease and type 2 diabetes: a review. Brain Res. Rev. 56, 384-402 (2007). (Pubitemid 350166529)
-
(2007)
Brain Research Reviews
, vol.56
, Issue.2
, pp. 384-402
-
-
Li, L.1
Holscher, C.2
-
64
-
-
34548249096
-
Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model
-
DOI 10.1111/j.1530-0277.2007.00450.x
-
Cohen, A. C., Tong, M., Wands, J. R. & de la Monte, S. M. Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model. Alcohol Clin. Exp. Res. 31, 1558-1573 (2007). (Pubitemid 47319658)
-
(2007)
Alcoholism: Clinical and Experimental Research
, vol.31
, Issue.9
, pp. 1558-1573
-
-
Cohen, A.C.1
Tong, M.2
Wands, J.R.3
De La Monte, S.M.4
-
65
-
-
1842684434
-
Insulin-like growth factor-I, cognition and brain aging
-
DOI 10.1016/j.ejphar.2004.02.047, PII S0014299904002043
-
van Dam, P. & Aleman, A. Insulin-like growth factor-I, cognition and brain aging. Eur. J. Pharmacol. 490, 87-95 (2004). (Pubitemid 38482163)
-
(2004)
European Journal of Pharmacology
, vol.490
, Issue.1-3
, pp. 87-95
-
-
Van Dam, P.S.1
Aleman, A.2
-
66
-
-
34347377319
-
Alzheimer-like changes in rat models of spontaneous diabetes
-
DOI 10.2337/db07-0171
-
Li, Z. G., Zhang, W. & Sima, A. A. Alzheimer-like changes in rat models of spontaneous diabetes. Diabetes 56, 1817-1824 (2007). (Pubitemid 47025451)
-
(2007)
Diabetes
, vol.56
, Issue.7
, pp. 1817-1824
-
-
Li, Z.-G.1
Zhang, W.2
Sima, A.A.F.3
-
67
-
-
1842633868
-
The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease
-
DOI 10.1016/j.ejphar.2004.02.050, PII S0014299904002079
-
Carro, E. & Torres, A. I. The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease. Eur. J. Pharmacol. 490, 127-133 (2004). (Pubitemid 38482166)
-
(2004)
European Journal of Pharmacology
, vol.490
, Issue.1-3
, pp. 127-133
-
-
Carro, E.1
Torres-Aleman, I.2
-
68
-
-
1842734649
-
Modulation of memory by insulin and glucose: Neuropsychological observations in Alzheimer's disease
-
DOI 10.1016/j.ejphar.2004.02.048, PII S0014299904002055
-
Watson, G. S. & Craft, S. Modulation of memory by insulin and glucose: neuropsychological observations in Alzheimer's disease. Eur. J. Pharmacol. 490, 97-113 (2004). (Pubitemid 38482164)
-
(2004)
European Journal of Pharmacology
, vol.490
, Issue.1-3
, pp. 97-113
-
-
Watson, G.S.1
Craft, S.2
-
69
-
-
1842633872
-
Insulin and the insulin receptor in experimental models of learning and memory
-
DOI 10.1016/j.ejphar.2004.02.045, PII S001429990400202X
-
Zhao, W. Q. Chen, H., Quon, M. J. & Alkon, D. L. Insulin and the insulin receptor in experimental models of learning and memory. Eur. J. Pharmacol. 490, 71-81 (2004). (Pubitemid 38482161)
-
(2004)
European Journal of Pharmacology
, vol.490
, Issue.1-3
, pp. 71-81
-
-
Zhao, W.-Q.1
Chen, H.2
Quon, M.J.3
Alkon, D.L.4
-
70
-
-
47849123972
-
Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-β in memory-impaired older adults
-
Reger, M. A. et al. Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-β in memory-impaired older adults. J. Alzheimers Dis. 13, 323-331 (2008). (Pubitemid 352039034)
-
(2008)
Journal of Alzheimer's Disease
, vol.13
, Issue.3
, pp. 323-331
-
-
Reger, M.A.1
Watson, G.S.2
Green, P.S.3
Baker, L.D.4
Cholerton, B.5
Fishel, M.A.6
Plymate, S.R.7
Cherrier, M.M.8
Schellenberg, G.D.9
Frey II, W.H.10
Craft, S.11
-
71
-
-
67649372868
-
A profile of impaired insulin degradation in relation to late-life cognitive decline: A preliminary investigation
-
Okereke, O. I. et al. A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigation. Int. J. Geriatr. Psychiatry 24, 177-182 (2008).
-
(2008)
Int. J. Geriatr. Psychiatry
, vol.24
, pp. 177-182
-
-
Okereke, O.I.1
-
72
-
-
40349091597
-
Intranasal insulin improves cognition and modulates β-amyloid in early AD
-
Reger, M. A. et al. Intranasal insulin improves cognition and modulates β-amyloid in early AD. Neurology 70, 440-448 (2008).
-
(2008)
Neurology
, vol.70
, pp. 440-448
-
-
Reger, M.A.1
-
73
-
-
78651274000
-
Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes
-
Baker, L. D. et al. Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. Arch. Neurol. 68, 51-57 (2010).
-
(2010)
Arch. Neurol.
, vol.68
, pp. 51-57
-
-
Baker, L.D.1
-
74
-
-
84855613853
-
Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: A pilot clinical trial
-
Craft, S. et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch. Neurol. 69, 29-38 (2012).
-
(2012)
Arch. Neurol
, vol.69
, pp. 29-38
-
-
Craft, S.1
-
76
-
-
0038248960
-
Glucagon-like peptide-1 decreases endogenous amyloid-β peptide (Aβ) levels and protects hippocampal neurons from death induced by Aβ and iron
-
DOI 10.1002/jnr.10611
-
Perry, T. et al. Glucagon-like peptide-1 decreases endogenous amyloid-β peptide (Aβ) levels and protects hippocampal neurons from death induced by Aβ and iron. J. Neurosci. Res. 72, 603-612 (2003). (Pubitemid 36578646)
-
(2003)
Journal of Neuroscience Research
, vol.72
, Issue.5
, pp. 603-612
-
-
Perry, T.1
Lahiri, D.K.2
Sambamurti, K.3
Chen, D.4
Mattson, M.P.5
Egan, J.M.6
Greig, N.H.7
-
77
-
-
84855548096
-
(Val8) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains
-
Li, L. et al. (Val8) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. Eur. J. Pharmacol. 674, 280-286 (2012).
-
(2012)
Eur. J. Pharmacol
, vol.674
, pp. 280-286
-
-
Li, L.1
-
78
-
-
0036182251
-
A novel neurotrophic property of glucagon-like peptide 1: A promoter of nerve growth factor-mediated differentiation in PC12 cells
-
DOI 10.1124/jpet.300.3.958
-
Perry, T. et al. A novel neutrotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. J. Pharmacol. Exp. Ther. 300, 958-966 (2002). (Pubitemid 34165002)
-
(2002)
Journal of Pharmacology and Experimental Therapeutics
, vol.300
, Issue.3
, pp. 958-966
-
-
Perry, T.1
Lahiri, D.K.2
Chen, D.3
Zhou, J.I.E.4
Shaw, K.T.Y.5
Egan, J.M.6
Greig, N.H.7
-
79
-
-
77957126457
-
Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats
-
Wang, X. H. et al. Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats. Neuroscience 170, 1239-1248 (2010).
-
(2010)
Neuroscience
, vol.170
, pp. 1239-1248
-
-
Wang, X.H.1
-
80
-
-
33748988258
-
Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
-
DOI 10.1038/sj.embor.7400784, PII 7400784
-
Radde, R. et al. Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep. 7, 940-946 (2006). (Pubitemid 44523975)
-
(2006)
EMBO Reports
, vol.7
, Issue.9
, pp. 940-946
-
-
Radde, R.1
Bolmont, T.2
Kaeser, S.A.3
Coomaraswamy, J.4
Lindau, D.5
Stoltze, L.6
Calhoun, M.E.7
Jaggi, F.8
Wolburg, H.9
Gengler, S.10
Haass, C.11
Ghetti, B.12
Czech, C.13
Holscher, C.14
Mathews, P.M.15
Jucker, M.16
-
81
-
-
82755176046
-
Val(8) GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
-
Gengler, S., McClean, P., McCurtin, R., Gault, V. & Holscher, C. Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol. Aging 33, 265-276 (2012).
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 265-276
-
-
Gengler, S.1
McClean, P.2
McCurtin, R.3
Gault, V.4
Holscher, C.5
-
82
-
-
79955749452
-
The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
-
McClean, P. L., Parthsarathy, V., Faivre, E. & Holscher, C. The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. J. Neurosci. 31, 6587-6594 (2011).
-
(2011)
J. Neurosci
, vol.31
, pp. 6587-6594
-
-
McClean, P.L.1
Parthsarathy, V.2
Faivre, E.3
Holscher, C.4
-
83
-
-
79751479118
-
Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain
-
Hamilton, A., Patterson, S., Porter, D., Gault, V. A. & Holscher, C. Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain. J. Neurosci. Res. 89, 481-489 (2011).
-
(2011)
J. Neurosci. Res
, vol.89
, pp. 481-489
-
-
Hamilton, A.1
Patterson, S.2
Porter, D.3
Gault, V.A.4
Holscher, C.5
-
84
-
-
0036198285
-
Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier
-
Kastin, A. J., Akerstrom, V. & Pan, W. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J. Mol. Neurosci. 18, 7-14 (2002). (Pubitemid 34252619)
-
(2002)
Journal of Molecular Neuroscience
, vol.18
, Issue.1-2
, pp. 7-14
-
-
Kastin, A.J.1
Akerstrom, V.2
Pan, W.3
-
85
-
-
0037349072
-
Entry of exendin-4 into brain is rapid but may be limited at high doses
-
DOI 10.1038/sj.ijo.0802206
-
Kastin, A. J. & Akerstrom, V. Entry of exendin-4 into brain is rapid but may be limited at high doses. Int. J. Obes. Relat. Metab. Disord. 27, 313-318 (2003). (Pubitemid 36384867)
-
(2003)
International Journal of Obesity
, vol.27
, Issue.3
, pp. 313-318
-
-
Kastin, A.J.1
Akerstrom, V.2
-
86
-
-
84868375789
-
Liraglutide a novel GLP-1 analogue, prevents the impairment of learning and LTP in an APP/PS-1 mouse model of Alzheimer's disease
-
Session 556.11, Poster K20 (Society for San Diego, California
-
McClean, P., Pathasarthy, V., Faivre, E. & Hφlscher, C. Liraglutide, a novel GLP-1 analogue, prevents the impairment of learning and LTP in an APP/PS-1 mouse model of Alzheimer's disease. Session 556.11, Poster K20 (Society for Neuroscience 40th Annual Meeting, San Diego, California; 2010).
-
(2010)
Neuroscience 40th Annual Meeting
-
-
McClean, P.1
Pathasarthy, V.2
Faivre, E.3
Hlscher, C.4
-
87
-
-
70350619609
-
Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study
-
Astrup, A. et al. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet 374, 1606-1616 (2009).
-
(2009)
Lancet
, vol.374
, pp. 1606-1616
-
-
Astrup, A.1
-
88
-
-
0035808264
-
Anti-amyloidogenic activity of tetracyclines: Studies in vitro
-
DOI 10.1016/S0014-5793(00)02380-2, PII S0014579300023802
-
Forloni, G., Colombo, L., Girola, L., Tagliavini, F. & Salmona, M. Anti-amyloidogenic activity of tetracyclines: studies in vitro. FEBS Lett. 487, 404-407 (2001). (Pubitemid 32121764)
-
(2001)
FEBS Letters
, vol.487
, Issue.3
, pp. 404-407
-
-
Forloni, G.1
Colombo, L.2
Girola, L.3
Tagliavini, F.4
Salmona, M.5
-
89
-
-
6044273035
-
Minocycline inhibits neuronal death and glial activation induced by β-amyloid peptide in rat hippocampus
-
DOI 10.1002/glia.20051
-
Ryu, J. K., Franciosi, S., Sattayaprasert, P., Kim, S. U. & McLarnon, J. G. Minocycline inhibits neuronal death and glial activation induced by β-amyloid peptide in rat hippocampus. Glia 48, 85-90 (2004). (Pubitemid 39390851)
-
(2004)
GLIA
, vol.48
, Issue.1
, pp. 85-90
-
-
Ryu, J.K.1
Franciosi, S.2
Sattayaprasert, P.3
Kim, S.U.4
McLarnon, J.G.5
-
90
-
-
33947545098
-
Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid
-
DOI 10.1523/JNEUROSCI.4371-06.2007
-
Fan, R. et al. Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid. J. Neurosci. 27, 3057-3063 (2007). (Pubitemid 46474134)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.12
, pp. 3057-3063
-
-
Fan, R.1
Xu, F.2
Previti, M.L.3
Davis, J.4
Grande, A.M.5
Robinson, J.K.6
Van Nostrand, W.E.7
-
91
-
-
65949120942
-
Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice
-
Garcia-Alloza, M. et al. Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice. J. Neurochem. 109, 1636-1647 (2009).
-
(2009)
J. Neurochem
, vol.109
, pp. 1636-1647
-
-
Garcia-Alloza, M.1
-
92
-
-
70349573768
-
Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding
-
Noble, W., Garwood, C. J. & Hanger, D. P. Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding. Prion 3, 78-83 (2009).
-
(2009)
Prion
, vol.3
, pp. 78-83
-
-
Noble, W.1
Garwood, C.J.2
Hanger, D.P.3
-
93
-
-
77957357526
-
Reductions in amyloid-β-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation
-
Parachikova, A., Vasilevko, V., Cribbs, D. H., LaFerla, F. M. & Green, K. N. Reductions in amyloid-β-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. J. Alzheimers Dis. 21, 527-542 (2010).
-
(2010)
J. Alzheimers Dis
, vol.21
, pp. 527-542
-
-
Parachikova, A.1
Vasilevko, V.2
Cribbs, D.H.3
Laferla, F.M.4
Green, K.N.5
-
94
-
-
79955941855
-
Increases in β-amyloid protein in the hippocampus caused by diabetic metabolic disorder are blocked by minocycline through inhibition of NF-κB pathway activation
-
Cai, Z. Y., Zhao, Y., Yao, S. T. & Zhao, B. Increases in β-amyloid protein in the hippocampus caused by diabetic metabolic disorder are blocked by minocycline through inhibition of NF-κB pathway activation. Pharmacol. Rep. 63, 381-391 (2011).
-
(2011)
Pharmacol. Rep
, vol.63
, pp. 381-391
-
-
Cai, Z.Y.1
Zhao, Y.2
Yao, S.T.3
Zhao, B.4
-
95
-
-
76749139924
-
Early-stage inflammation and experimental therapy in transgenic models of the Alzheimer-like amyloid pathology
-
Cuello, A. C. et al. Early-stage inflammation and experimental therapy in transgenic models of the Alzheimer-like amyloid pathology. Neurodegener. Dis. 7, 96-98 (2010).
-
(2010)
Neurodegener. Dis
, vol.7
, pp. 96-98
-
-
Cuello, A.C.1
-
96
-
-
33646243562
-
Minocycline affects microglia activation, Aβ deposition, and behavior in APP-tg mice
-
Seabrook, T. J., Jiang, L. Y., Maier, M. & Lemere, C. A. Minocycline affects microglia activation, Aβ deposition, and behavior in APP-tg mice. Glia 53, 776-782 (2006).
-
(2006)
Glia
, vol.53
, pp. 776-782
-
-
Seabrook, T.J.1
Jiang, L.Y.2
Maier, M.3
Lemere, C.A.4
-
97
-
-
62149143767
-
Minocycline reduces engraftment and activation of bone marrow-derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease
-
Malm, T. M. et al. Minocycline reduces engraftment and activation of bone marrow-derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease. Glia 56, 1767-1779 (2008).
-
(2008)
Glia
, vol.56
, pp. 1767-1779
-
-
Malm, T.M.1
-
98
-
-
40449086665
-
Dose translation from animal to human studies revisited
-
DOI 10.1096/fj.07-9574LSF
-
Reagan-Shaw, S., Nihal, M. & Ahmad, N. Dose translation from animal to human studies revisited. FASEB J. 22, 659-661 (2008). (Pubitemid 351348146)
-
(2008)
FASEB Journal
, vol.22
, Issue.3
, pp. 659-661
-
-
Reagan-Shaw, S.1
Nihal, M.2
Ahmad, N.3
-
99
-
-
36148960127
-
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: A phase III randomised trial
-
DOI 10.1016/S1474-4422(07)70270-3, PII S1474442207702703
-
Gordon, P. H. et al. Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a Phase III randomised trial. Lancet Neurol. 6, 1045-1053 (2007). (Pubitemid 350116691)
-
(2007)
Lancet Neurology
, vol.6
, Issue.12
, pp. 1045-1053
-
-
Gordon, P.H.1
Moore, D.H.2
Miller, R.G.3
Florence, J.M.4
Verheijde, J.L.5
Doorish, C.6
Hilton, J.F.7
Spitalny, G.M.8
MacArthur, R.B.9
Mitsumoto, H.10
Neville, H.E.11
Boylan, K.12
Mozaffar, T.13
Belsh, J.M.14
Ravits, J.15
Bedlack, R.S.16
Graves, M.C.17
McCluskey, L.F.18
Barohn, R.J.19
Tandan, R.20
more..
-
100
-
-
12244265476
-
Minocycline for Huntington's disease: An open label study
-
Bonelli, R. M., Heuberger, C. & Reisecker, F. Minocycline for Huntington's disease: an open label study. Neurology 60, 883-884 (2003). (Pubitemid 36297384)
-
(2003)
Neurology
, vol.60
, Issue.5
, pp. 883-884
-
-
Bonelli, R.M.1
Heuberger, C.2
Reisecker, F.3
-
101
-
-
8644235217
-
Neuroprotection in Huntington's disease: A 2-year study on minocycline
-
DOI 10.1097/00004850-200411000-00004
-
Bonelli, R. M., Hodl, A. K., Hofmann, P. & Kapfhammer, H. P. Neuroprotection in Huntington's disease: a 2-year study on minocycline. Int. Clin. Psychopharmacol. 19, 337-342 (2004). (Pubitemid 39506988)
-
(2004)
International Clinical Psychopharmacology
, vol.19
, Issue.6
, pp. 337-342
-
-
Bonelli, R.M.1
Hodl, A.K.2
Hofmann, P.3
Kapfhammer, H.-P.4
-
102
-
-
4444233214
-
Minocycline in Huntington's disease: A pilot study
-
DOI 10.1002/mds.20018
-
Thomas, M., Ashizawa, T. & Jankovic, J. Minocycline in Huntington's disease: a pilot study. Mov. Disord. 19, 692-695 (2004). (Pubitemid 39173025)
-
(2004)
Movement Disorders
, vol.19
, Issue.6
, pp. 692-695
-
-
Thomas, M.1
Ashizawa, T.2
Jankovic, J.3
-
103
-
-
78649369122
-
A futility study of minocycline in Huntington's disease
-
Schwarz, H. et al. A futility study of minocycline in Huntington's disease. Mov. Disord. 25, 2219-2224 (2010).
-
(2010)
Mov. Disord
, vol.25
, pp. 2219-2224
-
-
Schwarz, H.1
-
104
-
-
44649153832
-
A pilot clinical trial of creatine and minocycline in early Parkinson disease: 18-Month results
-
DOI 10.1097/WNF.0b013e3181342f32, PII 0000282620080500000003
-
Kieburtz, K. et al. A pilot clinical trial of creatine and minocycline in early Parkinson disease: 18-month results. Clin. Neuropharmacol. 31, 141-150 (2008). (Pubitemid 351787110)
-
(2008)
Clinical Neuropharmacology
, vol.31
, Issue.3
, pp. 141-150
-
-
Kieburtz, K.1
Tilley, B.2
Ravina, B.3
Galpern, W.4
Shannon, K.5
Tanner, C.6
Wooten, G.F.7
-
106
-
-
4344628460
-
Disruption of the retinoid signalling pathway causes a deposition of amyloid β in the adult rat brain
-
DOI 10.1111/j.1460-9568.2004.03563.x
-
Corcoran, J. P. T., So, P. L. & Maden, M. Disruption of the retinoid signalling pathway causes a deposition of amyloid β in the adult rat brain. Eur. J. Neurosci. 20, 896-902 (2004). (Pubitemid 39141297)
-
(2004)
European Journal of Neuroscience
, vol.20
, Issue.4
, pp. 896-902
-
-
Corcoran, J.P.T.1
Po, L.S.2
Maden, M.3
-
107
-
-
33747132102
-
Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in β-amyloid deposits in the cerebral cortex of vitamin A deprived rats
-
DOI 10.1016/j.nbd.2006.01.008, PII S0969996106000143
-
Husson, M. et al. Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in β-amyloid deposits in the cerebral cortex of vitamin A deprived rats. Neurobiol. Dis. 23, 1-10 (2006). (Pubitemid 44218979)
-
(2006)
Neurobiology of Disease
, vol.23
, Issue.1
, pp. 1-10
-
-
Husson, M.1
Enderlin, V.2
Delacourte, A.3
Ghenimi, N.4
Alfos, S.5
Pallet, V.6
Higueret, P.7
-
108
-
-
58149268892
-
Retinoic acid attenuates β-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model
-
Ding, Y. et al. Retinoic acid attenuates β-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model. J. Neurosci. 28, 11622-11634 (2008).
-
(2008)
J. Neurosci
, vol.28
, pp. 11622-11634
-
-
Ding, Y.1
-
109
-
-
67649359888
-
Up-regulation of the α-secretase ADAM10 by retinoic acid receptors and acitretin
-
Tippmann, F., Hundt, J., Schneider, A., Endres, K. & Fahrenholz, F. Up-regulation of the α-secretase ADAM10 by retinoic acid receptors and acitretin. FASEB J. 23, 1643-1654 (2009).
-
(2009)
FASEB J
, vol.23
, pp. 1643-1654
-
-
Tippmann, F.1
Hundt, J.2
Schneider, A.3
Endres, K.4
Fahrenholz, F.5
-
110
-
-
77958480110
-
Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β
-
Jarvis, C. I. et al. Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β. Eur. J. Neurosci. 32, 1246-1255 (2010).
-
(2010)
Eur. J. Neurosci
, vol.32
, pp. 1246-1255
-
-
Jarvis, C.I.1
-
111
-
-
67650717654
-
Oral administration of synthetic retinoid am80 (tamibarotene) decreases brain β-amyloid peptides in APP23 mice
-
Kawahara, K. et al. Oral administration of synthetic retinoid am80 (tamibarotene) decreases brain β-amyloid peptides in APP23 mice. Biol. Pharm. Bull. 32, 1307-1309 (2009).
-
(2009)
Biol. Pharm. Bull
, vol.32
, pp. 1307-1309
-
-
Kawahara, K.1
-
112
-
-
84862777666
-
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models
-
Cramer, P. E. et al. ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models. Science 335, 1503-1506 (2012).
-
(2012)
Science
, vol.335
, pp. 1503-1506
-
-
Cramer, P.E.1
-
113
-
-
79959772357
-
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance
-
Castellano, J. M. et al. Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci. Transl. Med. 3, 89ra57 (2011).
-
(2011)
Sci. Transl. Med
, vol.3
-
-
Castellano, J.M.1
-
114
-
-
0029827326
-
Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines
-
Melino, G. et al. Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines. Cell Growth Differ. 7, 787-796 (1996). (Pubitemid 26360747)
-
(1996)
Cell Growth and Differentiation
, vol.7
, Issue.6
, pp. 787-796
-
-
Melino, G.1
Draoui, M.2
Bernardini, S.3
Bellincampi, L.4
Reichert, U.5
Cohen, P.6
-
115
-
-
33748887415
-
Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth
-
So, P. L. et al. Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth. Dev. Biol. 298, 167-175 (2006).
-
(2006)
Dev. Biol
, vol.298
, pp. 167-175
-
-
So, P.L.1
-
116
-
-
58649112368
-
Sequential RARβ and α signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways
-
Goncalves, M. et al. Sequential RARβ and α signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways. Dev. Biol. 326, 305-313 (2009).
-
(2009)
Dev. Biol
, vol.326
, pp. 305-313
-
-
Goncalves, M.1
-
117
-
-
70849097441
-
All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease
-
Lee, H. P. et al. All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease. Expert Rev Neurother. 9, 1615-1621(2009).
-
(2009)
Expert Rev Neurother
, vol.9
, pp. 1615-1621
-
-
Lee, H.P.1
-
118
-
-
67149115541
-
Towards retinoid therapy for Alzheimer's disease
-
Shudo, K., Fukasawa, H., Nakagomi, M. & Yamagata, N. Towards retinoid therapy for Alzheimer's disease. Curr. Alzheimer Res. 6, 302-311 (2009).
-
(2009)
Curr. Alzheimer Res
, vol.6
, pp. 302-311
-
-
Shudo, K.1
Fukasawa, H.2
Nakagomi, M.3
Yamagata, N.4
-
119
-
-
0028085028
-
Kinetics of tissue distribution and elimination of retinoid drugs in the rat. I. Acitretin
-
Eisenhardt, E. U. & Bickel, M. H. Kinetics of tissue distribution and elimination of retinoid drugs in the rat. I. Acitretin. Drug Metab. Dispos. 22, 26-30 (1994). (Pubitemid 24045375)
-
(1994)
Drug Metabolism and Disposition
, vol.22
, Issue.1
, pp. 26-30
-
-
Eisenhardt, E.U.1
Bickel, M.H.2
-
120
-
-
0037713314
-
Persistence of cognitive impairment in geriatric patients following antidepressant treatment: A randomized, double-blind clinical trial with nortriptyline and paroxetine
-
DOI 10.1016/S0022-3956(02)00085-7, PII S0022395602000857
-
Nebes, R. D. et al. Persistence of cognitive impairment in geriatric patients following antidepressant treatment: a randomized, double-blind clinical trial with nortriptyline and paroxetine. J. Psychiatr. Res. 37, 99-108 (2003). (Pubitemid 36808472)
-
(2003)
Journal of Psychiatric Research
, vol.37
, Issue.2
, pp. 99-108
-
-
Nebes, R.D.1
Pollock, B.G.2
Houck, P.R.3
Butters, M.A.4
Mulsant, B.H.5
Zmuda, M.D.6
Reynolds III, C.F.7
-
121
-
-
43049129922
-
An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers
-
Scholey, A. B. et al. An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers. Psychopharmacology 198, 127-139 (2008).
-
(2008)
Psychopharmacology
, vol.198
, pp. 127-139
-
-
Scholey, A.B.1
-
122
-
-
74949089743
-
Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia
-
McGuinness, B., Todd, S., Passmore, P. & Bullock, R. Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia. Cochrane Database Syst. Rev. 2009, CD004034 (2009).
-
(2009)
Cochrane Database Syst. Rev
, vol.2009
-
-
McGuinness, B.1
Todd, S.2
Passmore, P.3
Bullock, R.4
-
123
-
-
78149245073
-
Role of inflammation in cognitive impairment: Results of observational epidemiological studies and clinical trials
-
Gorelick, P. B. Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials. Ann. NY Acad. Sci. 1207, 155-162 (2010).
-
(2010)
Ann. NY Acad. Sci
, vol.1207
, pp. 155-162
-
-
Gorelick, P.B.1
-
124
-
-
84861314593
-
Steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease
-
Jaturapatporn, D., Isaac, M., McCleery, J. & Tabet, N. Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease. Cochrane Database Syst. Rev. 2012, CD006378 (2012).
-
(2012)
Cochrane Database Syst. Rev
, vol.2012
-
-
Jaturapatporn, D.1
Isaac, M.2
McCleery, J.3
Aspirin, T.N.4
-
125
-
-
70349570588
-
Systemic inflammation and disease progression in Alzheimer disease
-
Holmes, C. et al. Systemic inflammation and disease progression in Alzheimer disease. Neurology 73, 768-774 (2009).
-
(2009)
Neurology
, vol.73
, pp. 768-774
-
-
Holmes, C.1
-
126
-
-
77954623308
-
Improvement of cognition, a potential benefit of anti-TNF therapy in elderly patients with rheumatoid arthritis
-
Chen, Y. M., Chen, H. H., Lan, J. L. & Chen, D. Y. Improvement of cognition, a potential benefit of anti-TNF therapy in elderly patients with rheumatoid arthritis. Joint Bone Spine 77, 366-367 (2010).
-
(2010)
Joint Bone Spine
, vol.77
, pp. 366-367
-
-
Chen, Y.M.1
Chen, H.H.2
Lan, J.L.3
Chen, D.Y.4
-
127
-
-
77958567930
-
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: A randomized controlled trial
-
Smith, A. D. et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS ONE 5, e12244 (2010).
-
(2010)
PLoS ONE
, vol.5
-
-
Smith, A.D.1
-
129
-
-
58449130099
-
Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques
-
Wozniak, M. A., Mee, A. P. & Itzhaki, R. F. Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques. J. Pathol. 217, 131-138 (2009).
-
(2009)
J. Pathol
, vol.217
, pp. 131-138
-
-
Wozniak, M.A.1
Mee, A.P.2
Itzhaki, R.F.3
-
130
-
-
47849119723
-
Herpes simplex virus type 1 in Alzheimer's disease: The enemy within
-
Itzhaki, R. F. & Wozniak, M. A. Herpes simplex virus type 1 in Alzheimer's disease: the enemy within. J. Alzheimers Dis. 13, 393-405 (2008). (Pubitemid 352039023)
-
(2008)
Journal of Alzheimer's Disease
, vol.13
, Issue.4
, pp. 393-405
-
-
Itzhaki, R.F.1
Wozniak, M.A.2
-
131
-
-
48249096759
-
A feasibility and tolerability study of lithium in Alzheimer's disease
-
Macdonald, A. et al. A feasibility and tolerability study of lithium in Alzheimer's disease. Int. J. Geriatr. Psychiatry 23, 704-711 (2008).
-
(2008)
Int. J. Geriatr. Psychiatry
, vol.23
, pp. 704-711
-
-
MacDonald, A.1
-
132
-
-
67649206084
-
Lithium trial in Alzheimer's disease: A randomized, single-blind, placebo-controlled, multicenter 10-week study
-
Hampel, H. et al. Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study. J. Clin. Psychiatry 70, 922-931 (2009).
-
(2009)
J. Clin. Psychiatry
, vol.70
, pp. 922-931
-
-
Hampel, H.1
-
133
-
-
70349638299
-
Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies
-
Brunden, K. R., Trojanowski, J. Q. & Lee, V. M. Y. Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. Nature Rev. Drug Discov. 8, 783-793 (2009).
-
(2009)
Nature Rev. Drug Discov
, vol.8
, pp. 783-793
-
-
Brunden, K.R.1
Trojanowski, J.Q.2
Lee, V.M.Y.3
-
134
-
-
79952439187
-
Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes
-
Gupta, A., Bisht, B. & Dey, C. S. Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes. Neuropharmacology 60, 910-920 (2011).
-
(2011)
Neuropharmacology
, vol.60
, pp. 910-920
-
-
Gupta, A.1
Bisht, B.2
Dey, C.S.3
-
135
-
-
79956277464
-
Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin
-
Hsu, C. C., Wahlqvist, M. L., Lee, M. S. & Tsai, H. N. Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin. J. Alzheimers Dis. 24, 485-493 (2011).
-
(2011)
J. Alzheimers Dis
, vol.24
, pp. 485-493
-
-
Hsu, C.C.1
Wahlqvist, M.L.2
Lee, M.S.3
Tsai, H.N.4
-
136
-
-
12144290676
-
A randomized, controlled trial of doxycycline and rifampin for patients with alzheimer's disease
-
DOI 10.1111/j.1532-5415.2004.52109.x
-
Loeb, M. B. et al. A randomized, controlled trial of doxycycline and rifampin for patients with Alzheimer's disease. J. Am. Geriatr. Soc. 52, 381-387 (2004). (Pubitemid 38339518)
-
(2004)
Journal of the American Geriatrics Society
, vol.52
, Issue.3
, pp. 381-387
-
-
Loeb, M.B.1
Molloy, D.W.2
Smieja, M.3
Standish, T.4
Goldsmith, C.H.5
Mahony, J.6
Smith, S.7
Borrie, M.8
Decoteau, E.9
Davidson, W.10
McDougall, A.11
Gnarpe, J.12
O'Donnell, M.13
Chernesky, M.14
-
137
-
-
82255160648
-
Chronic divalproex sodium use and brain atrophy in Alzheimer disease
-
Fleisher, A. S. et al. Chronic divalproex sodium use and brain atrophy in Alzheimer disease. Neurology 77, 1263-1271 (2011).
-
(2011)
Neurology
, vol.77
, pp. 1263-1271
-
-
Fleisher, A.S.1
-
138
-
-
77956090575
-
Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: Results from a randomized, double-blind, placebo-controlled Phase III study
-
Gold, M. et al. Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled Phase III study. Dementia Geriatr. Cognitive Disord. 30, 131-146 (2010).
-
(2010)
Dementia Geriatr. Cognitive Disord
, vol.30
, pp. 131-146
-
-
Gold, M.1
-
139
-
-
79959479102
-
Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer's disease
-
Sato T. et al. Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer's disease. Neurobiol. Aging 32, 1626-1633 (2011).
-
(2011)
Neurobiol. Aging
, vol.32
, pp. 1626-1633
-
-
Sato, T.1
|