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Volumn 33, Issue 11, 2017, Pages 882-894

piRNA Biogenesis in Drosophila melanogaster

Author keywords

[No Author keywords available]

Indexed keywords

PIWI INTERACTING RNA; PIWI PROTEIN; RNA PRECURSOR; SMALL INTERFERING RNA;

EID: 85030168442     PISSN: 01689525     EISSN: 13624555     Source Type: Journal    
DOI: 10.1016/j.tig.2017.09.002     Document Type: Review
Times cited : (110)

References (120)
  • 1
    • 84879414849 scopus 로고    scopus 로고
    • Argonaute proteins: functional insights and emerging roles
    • Meister, G., Argonaute proteins: functional insights and emerging roles. Nat. Rev. Genet. 14 (2013), 447–459.
    • (2013) Nat. Rev. Genet. , vol.14 , pp. 447-459
    • Meister, G.1
  • 2
    • 23144438396 scopus 로고    scopus 로고
    • Crystal structure of A-aeolicus Argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage
    • Yuan, Y.R., et al. Crystal structure of A-aeolicus Argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol. Cell 19 (2005), 405–419.
    • (2005) Mol. Cell , vol.19 , pp. 405-419
    • Yuan, Y.R.1
  • 3
    • 18744407284 scopus 로고    scopus 로고
    • Purified Argonaute2 and an siRNA form recombinant human RISC
    • Rivas, F.V., et al. Purified Argonaute2 and an siRNA form recombinant human RISC. Nat. Struct. Mol. Biol. 12 (2005), 340–349.
    • (2005) Nat. Struct. Mol. Biol. , vol.12 , pp. 340-349
    • Rivas, F.V.1
  • 4
    • 58849112575 scopus 로고    scopus 로고
    • Biogenesis of small RNAs in animals
    • Kim, V.N., et al. Biogenesis of small RNAs in animals. Nat. Rev. Mol. Cell Biol. 10 (2009), 126–139.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 126-139
    • Kim, V.N.1
  • 5
    • 0036828639 scopus 로고    scopus 로고
    • The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis
    • Carmell, M.A., et al. The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev. 16 (2002), 2733–2742.
    • (2002) Genes Dev. , vol.16 , pp. 2733-2742
    • Carmell, M.A.1
  • 6
    • 34249810892 scopus 로고    scopus 로고
    • Argonaute proteins: mediators of RNA silencing
    • Peters, L., Meister, G., Argonaute proteins: mediators of RNA silencing. Mol. Cell 26 (2007), 611–623.
    • (2007) Mol. Cell , vol.26 , pp. 611-623
    • Peters, L.1    Meister, G.2
  • 7
    • 0032443562 scopus 로고    scopus 로고
    • A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal
    • Cox, D.N., et al. A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal. Genes Dev. 12 (1998), 3715–3727.
    • (1998) Genes Dev. , vol.12 , pp. 3715-3727
    • Cox, D.N.1
  • 8
    • 0033966406 scopus 로고    scopus 로고
    • piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells
    • Cox, D.N., et al. piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells. Development 127 (2000), 503–514.
    • (2000) Development , vol.127 , pp. 503-514
    • Cox, D.N.1
  • 9
    • 33745402414 scopus 로고    scopus 로고
    • A novel class of small RNAs bind to MILI protein in mouse testes
    • Aravin, A., et al. A novel class of small RNAs bind to MILI protein in mouse testes. Nature 442 (2006), 203–207.
    • (2006) Nature , vol.442 , pp. 203-207
    • Aravin, A.1
  • 10
    • 33745336617 scopus 로고    scopus 로고
    • A germline-specific class of small RNAs binds mammalian Piwi proteins
    • Girard, A., et al. A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature 442 (2006), 199–202.
    • (2006) Nature , vol.442 , pp. 199-202
    • Girard, A.1
  • 11
    • 33745621037 scopus 로고    scopus 로고
    • A novel class of small RNAs in mouse spermatogenic cells
    • Grivna, S.T., et al. A novel class of small RNAs in mouse spermatogenic cells. Genes Dev. 20 (2006), 1709–1714.
    • (2006) Genes Dev. , vol.20 , pp. 1709-1714
    • Grivna, S.T.1
  • 12
    • 33746527679 scopus 로고    scopus 로고
    • Characterization of the piRNA complex from rat testes
    • Lau, N.C., et al. Characterization of the piRNA complex from rat testes. Science 313 (2006), 363–367.
    • (2006) Science , vol.313 , pp. 363-367
    • Lau, N.C.1
  • 13
    • 33745599586 scopus 로고    scopus 로고
    • Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
    • Watanabe, T., et al. Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. Genes Dev. 20 (2006), 1732–1743.
    • (2006) Genes Dev. , vol.20 , pp. 1732-1743
    • Watanabe, T.1
  • 14
    • 0026337934 scopus 로고
    • Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology
    • Schupbach, T., Wieschaus, E., Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics 129 (1991), 1119–1136.
    • (1991) Genetics , vol.129 , pp. 1119-1136
    • Schupbach, T.1    Wieschaus, E.2
  • 15
    • 33947720638 scopus 로고    scopus 로고
    • MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline
    • Carmell, M.A., et al. MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev. Cell 12 (2007), 503–514.
    • (2007) Dev. Cell , vol.12 , pp. 503-514
    • Carmell, M.A.1
  • 16
    • 41649116098 scopus 로고    scopus 로고
    • DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes
    • Kuramochi-Miyagawa, S., et al. DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev. 22 (2008), 908–917.
    • (2008) Genes Dev. , vol.22 , pp. 908-917
    • Kuramochi-Miyagawa, S.1
  • 17
    • 70350238350 scopus 로고    scopus 로고
    • The biogenesis and function of PIWI proteins and piRNAs: progress and prospect
    • Thomson, T., Lin, H., The biogenesis and function of PIWI proteins and piRNAs: progress and prospect. Annu. Rev. Cell Dev. Biol. 25 (2009), 355–376.
    • (2009) Annu. Rev. Cell Dev. Biol. , vol.25 , pp. 355-376
    • Thomson, T.1    Lin, H.2
  • 18
    • 85061111209 scopus 로고    scopus 로고
    • The RNA interference proteins and vasa locus are involved in the silencing of retrotransposons in the female germline of Drosophila melanogaster
    • Vagin, V.V., et al. The RNA interference proteins and vasa locus are involved in the silencing of retrotransposons in the female germline of Drosophila melanogaster. RNA Biol. 1 (2004), 54–58.
    • (2004) RNA Biol. , vol.1 , pp. 54-58
    • Vagin, V.V.1
  • 19
    • 17144417381 scopus 로고    scopus 로고
    • Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline
    • Kalmykova, A.I., et al. Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline. Nucl. Acids Res. 33 (2005), 2052–2059.
    • (2005) Nucl. Acids Res. , vol.33 , pp. 2052-2059
    • Kalmykova, A.I.1
  • 20
    • 33947273235 scopus 로고    scopus 로고
    • Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila
    • Brennecke, J., et al. Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell 128 (2007), 1089–1103.
    • (2007) Cell , vol.128 , pp. 1089-1103
    • Brennecke, J.1
  • 21
    • 65549118489 scopus 로고    scopus 로고
    • Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies
    • Li, C., et al. Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell 137 (2009), 509–521.
    • (2009) Cell , vol.137 , pp. 509-521
    • Li, C.1
  • 22
    • 0035838369 scopus 로고    scopus 로고
    • Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline
    • Aravin, A.A., et al. Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline. Curr. Biol. 11 (2001), 1017–1027.
    • (2001) Curr. Biol. , vol.11 , pp. 1017-1027
    • Aravin, A.A.1
  • 23
    • 33947390781 scopus 로고    scopus 로고
    • A slicer-mediated mechanism for repeat-associated siRNA 5′ end formation in Drosophila
    • Gunawardane, L.S., et al. A slicer-mediated mechanism for repeat-associated siRNA 5′ end formation in Drosophila. Science 315 (2007), 1587–1590.
    • (2007) Science , vol.315 , pp. 1587-1590
    • Gunawardane, L.S.1
  • 24
    • 35548991887 scopus 로고    scopus 로고
    • Gene silencing mechanisms mediated by Aubergine piRNA complexes in Drosophila male gonad
    • Nishida, K.M., et al. Gene silencing mechanisms mediated by Aubergine piRNA complexes in Drosophila male gonad. RNA 13 (2007), 1911–1922.
    • (2007) RNA , vol.13 , pp. 1911-1922
    • Nishida, K.M.1
  • 25
    • 33746502166 scopus 로고    scopus 로고
    • A distinct small RNA pathway silences selfish genetic elements in the germline
    • Vagin, V.V., et al. A distinct small RNA pathway silences selfish genetic elements in the germline. Science 313 (2006), 320–324.
    • (2006) Science , vol.313 , pp. 320-324
    • Vagin, V.V.1
  • 26
    • 33845741236 scopus 로고    scopus 로고
    • Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response
    • Klattenhoff, C., et al. Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response. Dev. Cell 12 (2007), 45–55.
    • (2007) Dev. Cell , vol.12 , pp. 45-55
    • Klattenhoff, C.1
  • 27
    • 38849167412 scopus 로고    scopus 로고
    • Biogenesis and germline functions of piRNAs
    • Klattenhoff, C., Theurkauf, W., Biogenesis and germline functions of piRNAs. Development 135 (2008), 3–9.
    • (2008) Development , vol.135 , pp. 3-9
    • Klattenhoff, C.1    Theurkauf, W.2
  • 28
    • 33947641533 scopus 로고    scopus 로고
    • Cutoff and aubergine mutations result in retrotransposon upregulation and checkpoint activation in Drosophila
    • Chen, Y., et al. Cutoff and aubergine mutations result in retrotransposon upregulation and checkpoint activation in Drosophila. Curr. Biol. 17 (2007), 637–642.
    • (2007) Curr. Biol. , vol.17 , pp. 637-642
    • Chen, Y.1
  • 29
    • 84889667828 scopus 로고    scopus 로고
    • Distribution, evolution, and diversity of retrotransposons at the flamenco locus reflect the regulatory properties of piRNA clusters
    • Zanni, V., et al. Distribution, evolution, and diversity of retrotransposons at the flamenco locus reflect the regulatory properties of piRNA clusters. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 19842–19847.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 19842-19847
    • Zanni, V.1
  • 30
    • 84898661166 scopus 로고    scopus 로고
    • Transcriptional properties and splicing of the flamenco piRNA cluster
    • Goriaux, C., et al. Transcriptional properties and splicing of the flamenco piRNA cluster. EMBO Rep. 15 (2014), 411–418.
    • (2014) EMBO Rep. , vol.15 , pp. 411-418
    • Goriaux, C.1
  • 31
    • 84902108866 scopus 로고    scopus 로고
    • The Rhino-Deadlock-Cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila
    • Mohn, F., et al. The Rhino-Deadlock-Cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila. Cell 157 (2014), 1364–1379.
    • (2014) Cell , vol.157 , pp. 1364-1379
    • Mohn, F.1
  • 32
    • 84992316144 scopus 로고    scopus 로고
    • Cutoff suppresses RNA polymerase II termination to ensure expression of piRNA precursors
    • Chen, Y.C.A., et al. Cutoff suppresses RNA polymerase II termination to ensure expression of piRNA precursors. Mol. Cell 63 (2016), 97–109.
    • (2016) Mol. Cell , vol.63 , pp. 97-109
    • Chen, Y.C.A.1
  • 33
    • 84874230944 scopus 로고    scopus 로고
    • Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state
    • Le Thomas, A., et al. Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Genes Dev. 27 (2013), 390–399.
    • (2013) Genes Dev. , vol.27 , pp. 390-399
    • Le Thomas, A.1
  • 34
    • 84901740683 scopus 로고    scopus 로고
    • Euchromatic transposon insertions trigger production of novel Pi- and endo-siRNAs at the target sites in the Drosophila germline
    • Shpiz, S., et al. Euchromatic transposon insertions trigger production of novel Pi- and endo-siRNAs at the target sites in the Drosophila germline. PLoS Genet., 10, 2014, e1004138.
    • (2014) PLoS Genet. , vol.10 , pp. e1004138
    • Shpiz, S.1
  • 35
    • 84878884615 scopus 로고    scopus 로고
    • De novo piRNA cluster formation in the Drosophila germ line triggered by transgenes containing a transcribed transposon fragment
    • Olovnikov, I., et al. De novo piRNA cluster formation in the Drosophila germ line triggered by transgenes containing a transcribed transposon fragment. Nucl. Acids Res. 41 (2013), 5757–5768.
    • (2013) Nucl. Acids Res. , vol.41 , pp. 5757-5768
    • Olovnikov, I.1
  • 36
    • 72649094955 scopus 로고    scopus 로고
    • A broadly conserved pathway generates 3′ UTR-directed primary piRNAs
    • Robine, N., et al. A broadly conserved pathway generates 3′ UTR-directed primary piRNAs. Curr. Biol. 19 (2009), 2066–2076.
    • (2009) Curr. Biol. , vol.19 , pp. 2066-2076
    • Robine, N.1
  • 37
    • 70449519397 scopus 로고    scopus 로고
    • A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila
    • 1296–U1135
    • Saito, K., et al. A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila. Nature, 461, 2009 1296–U1135.
    • (2009) Nature , vol.461
    • Saito, K.1
  • 38
    • 84870060785 scopus 로고    scopus 로고
    • Transcriptional silencing of transposons by Piwi and Maelstrom and its impact on chromatin state and gene expression
    • Sienski, G., et al. Transcriptional silencing of transposons by Piwi and Maelstrom and its impact on chromatin state and gene expression. Cell 151 (2012), 964–980.
    • (2012) Cell , vol.151 , pp. 964-980
    • Sienski, G.1
  • 39
    • 84874240831 scopus 로고    scopus 로고
    • Multiple roles for Piwi in silencing Drosophila transposons
    • Rozhkov, N.V., et al. Multiple roles for Piwi in silencing Drosophila transposons. Genes Dev. 27 (2013), 400–412.
    • (2013) Genes Dev. , vol.27 , pp. 400-412
    • Rozhkov, N.V.1
  • 40
    • 84903167266 scopus 로고    scopus 로고
    • Impact of nuclear Piwi elimination on chromatin state in Drosophila melanogaster ovaries
    • Klenov, M.S., et al. Impact of nuclear Piwi elimination on chromatin state in Drosophila melanogaster ovaries. Nucl. Acids Res. 42 (2014), 6208–6218.
    • (2014) Nucl. Acids Res. , vol.42 , pp. 6208-6218
    • Klenov, M.S.1
  • 41
    • 84902117162 scopus 로고    scopus 로고
    • The HP1 homolog Rhino anchors a nuclear complex that suppresses piRNA precursor splicing
    • Zhang, Z., et al. The HP1 homolog Rhino anchors a nuclear complex that suppresses piRNA precursor splicing. Cell 157 (2014), 1353–1363.
    • (2014) Cell , vol.157 , pp. 1353-1363
    • Zhang, Z.1
  • 42
    • 80051962655 scopus 로고    scopus 로고
    • piRNA production requires heterochromatin formation in Drosophila
    • Rangan, P., et al. piRNA production requires heterochromatin formation in Drosophila. Curr. Biol. 21 (2011), 1373–1379.
    • (2011) Curr. Biol. , vol.21 , pp. 1373-1379
    • Rangan, P.1
  • 43
    • 84905270270 scopus 로고    scopus 로고
    • Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing
    • Le Thomas, A., et al. Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing. Genes Dev. 28 (2014), 1667–1680.
    • (2014) Genes Dev. , vol.28 , pp. 1667-1680
    • Le Thomas, A.1
  • 44
    • 84907388228 scopus 로고    scopus 로고
    • A transgenerational process defines piRNA biogenesis in Drosophila virilis
    • Le Thomas, A., et al. A transgenerational process defines piRNA biogenesis in Drosophila virilis. Cell Rep. 8 (2014), 1617–1623.
    • (2014) Cell Rep. , vol.8 , pp. 1617-1623
    • Le Thomas, A.1
  • 45
    • 69249225196 scopus 로고    scopus 로고
    • The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters
    • Klattenhoff, C., et al. The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters. Cell 138 (2009), 1137–1149.
    • (2009) Cell , vol.138 , pp. 1137-1149
    • Klattenhoff, C.1
  • 46
    • 81255137997 scopus 로고    scopus 로고
    • The Cutoff protein regulates piRNA cluster expression and piRNA production in the Drosophila germline
    • Pane, A., et al. The Cutoff protein regulates piRNA cluster expression and piRNA production in the Drosophila germline. EMBO J. 30 (2011), 4601–4615.
    • (2011) EMBO J. , vol.30 , pp. 4601-4615
    • Pane, A.1
  • 47
    • 84878851966 scopus 로고    scopus 로고
    • A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway
    • Czech, B., et al. A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway. Mol. Cell 50 (2013), 749–761.
    • (2013) Mol. Cell , vol.50 , pp. 749-761
    • Czech, B.1
  • 48
    • 84926518979 scopus 로고    scopus 로고
    • Structural insights into Rhino-mediated germline piRNA cluster formation
    • Yu, B.W., et al. Structural insights into Rhino-mediated germline piRNA cluster formation. Cell Res. 25 (2015), 525–528.
    • (2015) Cell Res. , vol.25 , pp. 525-528
    • Yu, B.W.1
  • 49
    • 85021085796 scopus 로고    scopus 로고
    • Integrative analysis unveils new functions for the Drosophila Cutoff protein in noncoding RNA biogenesis and gene regulation
    • Pritykin, Y., et al. Integrative analysis unveils new functions for the Drosophila Cutoff protein in noncoding RNA biogenesis and gene regulation. RNA 23 (2017), 1097–1109.
    • (2017) RNA , vol.23 , pp. 1097-1109
    • Pritykin, Y.1
  • 50
    • 85029101508 scopus 로고    scopus 로고
    • A heterochromatin-dependent transcription machinery drives piRNA expression
    • Andersen, P.R., et al. A heterochromatin-dependent transcription machinery drives piRNA expression. Nature 549 (2017), 54–59.
    • (2017) Nature , vol.549 , pp. 54-59
    • Andersen, P.R.1
  • 51
    • 84962381499 scopus 로고    scopus 로고
    • Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila
    • Hur, J.K., et al. Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila. Genes Dev. 30 (2016), 840–855.
    • (2016) Genes Dev. , vol.30 , pp. 840-855
    • Hur, J.K.1
  • 52
    • 84869016142 scopus 로고    scopus 로고
    • UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery
    • Zhang, F., et al. UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery. Cell 151 (2012), 871–884.
    • (2012) Cell , vol.151 , pp. 871-884
    • Zhang, F.1
  • 53
    • 0037118052 scopus 로고    scopus 로고
    • TREX is a conserved complex coupling transcription with messenger RNA export
    • Strasser, K., et al. TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417 (2002), 304–308.
    • (2002) Nature , vol.417 , pp. 304-308
    • Strasser, K.1
  • 54
    • 84860473143 scopus 로고    scopus 로고
    • mRNA export and the TREX complex
    • Katahira, J., mRNA export and the TREX complex. BBA-Gene Regul. Mech. 1819 (2012), 507–513.
    • (2012) BBA-Gene Regul. Mech. , vol.1819 , pp. 507-513
    • Katahira, J.1
  • 55
    • 0038699144 scopus 로고    scopus 로고
    • Coupling transcription, splicing and mRNA export
    • Reed, R., Coupling transcription, splicing and mRNA export. Curr. Opin. Cell Biol. 15 (2003), 326–331.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 326-331
    • Reed, R.1
  • 56
    • 22344438756 scopus 로고    scopus 로고
    • Recruitment of the human TREX complex to mRNA during splicing
    • Masuda, S., et al. Recruitment of the human TREX complex to mRNA during splicing. Genes Dev. 19 (2005), 1512–1517.
    • (2005) Genes Dev. , vol.19 , pp. 1512-1517
    • Masuda, S.1
  • 57
    • 84862673628 scopus 로고    scopus 로고
    • RNA polymerase backtracking in gene regulation and genome instability
    • Nudler, E., RNA polymerase backtracking in gene regulation and genome instability. Cell 149 (2012), 1438–1445.
    • (2012) Cell , vol.149 , pp. 1438-1445
    • Nudler, E.1
  • 58
    • 85005959339 scopus 로고    scopus 로고
    • Export of piRNA precursors by EJC triggers assembly of cytoplasmic Yb-body in Drosophila
    • Dennis, C., et al. Export of piRNA precursors by EJC triggers assembly of cytoplasmic Yb-body in Drosophila. Nat. Commun., 7, 2016, 13739.
    • (2016) Nat. Commun. , vol.7 , pp. 13739
    • Dennis, C.1
  • 59
    • 84893013259 scopus 로고    scopus 로고
    • To be or not to be a piRNA: genomic origin and processing of piRNAs
    • Le Thomas, A., et al. To be or not to be a piRNA: genomic origin and processing of piRNAs. Genome Biol., 15, 2014, 204.
    • (2014) Genome Biol. , vol.15 , pp. 204
    • Le Thomas, A.1
  • 60
    • 84868626090 scopus 로고    scopus 로고
    • Structure and function of Zucchini endoribonuclease in piRNA biogenesis
    • Nishimasu, H., et al. Structure and function of Zucchini endoribonuclease in piRNA biogenesis. Nature 491 (2012), 284–287.
    • (2012) Nature , vol.491 , pp. 284-287
    • Nishimasu, H.1
  • 61
    • 84868613084 scopus 로고    scopus 로고
    • The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis
    • Ipsaro, J.J., et al. The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature 491 (2012), 279–283.
    • (2012) Nature , vol.491 , pp. 279-283
    • Ipsaro, J.J.1
  • 62
    • 34249309547 scopus 로고    scopus 로고
    • Zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline
    • Pane, A., et al. Zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline. Dev. Cell 12 (2007), 851–862.
    • (2007) Dev. Cell , vol.12 , pp. 851-862
    • Pane, A.1
  • 63
    • 84869825301 scopus 로고    scopus 로고
    • Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc
    • Voigt, F., et al. Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc. RNA 18 (2012), 2128–2134.
    • (2012) RNA , vol.18 , pp. 2128-2134
    • Voigt, F.1
  • 64
    • 36749037521 scopus 로고    scopus 로고
    • The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race
    • Aravin, A.A., et al. The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science 318 (2007), 761–764.
    • (2007) Science , vol.318 , pp. 761-764
    • Aravin, A.A.1
  • 65
    • 34248160438 scopus 로고    scopus 로고
    • Developmentally regulated piRNA clusters implicate MILI in transposon control
    • Aravin, A.A., et al. Developmentally regulated piRNA clusters implicate MILI in transposon control. Science 316 (2007), 744–747.
    • (2007) Science , vol.316 , pp. 744-747
    • Aravin, A.A.1
  • 66
    • 34047154356 scopus 로고    scopus 로고
    • A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in zebrafish
    • Houwing, S., et al. A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in zebrafish. Cell 129 (2007), 69–82.
    • (2007) Cell , vol.129 , pp. 69-82
    • Houwing, S.1
  • 67
    • 55249115975 scopus 로고    scopus 로고
    • Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals
    • Grimson, A., et al. Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals. Nature 455 (2008), 1193–1197.
    • (2008) Nature , vol.455 , pp. 1193-1197
    • Grimson, A.1
  • 68
    • 84892487532 scopus 로고    scopus 로고
    • Analysis of Hydra PIWI proteins and piRNAs uncover early evolutionary origins of the piRNA pathway
    • Lim, R.S.M., et al. Analysis of Hydra PIWI proteins and piRNAs uncover early evolutionary origins of the piRNA pathway. Dev. Biol. 386 (2014), 237–251.
    • (2014) Dev. Biol. , vol.386 , pp. 237-251
    • Lim, R.S.M.1
  • 69
    • 52049098967 scopus 로고    scopus 로고
    • A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice
    • Aravin, A.A., et al. A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol. Cell 31 (2008), 785–799.
    • (2008) Mol. Cell , vol.31 , pp. 785-799
    • Aravin, A.A.1
  • 70
    • 57149104113 scopus 로고    scopus 로고
    • An epigenetic role for maternally inherited piRNAs in transposon silencing
    • Brennecke, J., et al. An epigenetic role for maternally inherited piRNAs in transposon silencing. Science 322 (2008), 1387–1392.
    • (2008) Science , vol.322 , pp. 1387-1392
    • Brennecke, J.1
  • 71
    • 84957831282 scopus 로고    scopus 로고
    • Paramutation in Drosophila requires both nuclear and cytoplasmic actors of the piRNA pathway and induces Cis-spreading of piRNA production
    • Hermant, C., et al. Paramutation in Drosophila requires both nuclear and cytoplasmic actors of the piRNA pathway and induces Cis-spreading of piRNA production. Genetics 201 (2015), 1381–1396.
    • (2015) Genetics , vol.201 , pp. 1381-1396
    • Hermant, C.1
  • 72
    • 84929380410 scopus 로고    scopus 로고
    • piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production
    • Han, B.W., et al. piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production. Science 348 (2015), 817–821.
    • (2015) Science , vol.348 , pp. 817-821
    • Han, B.W.1
  • 73
    • 84929353775 scopus 로고    scopus 로고
    • piRNA-guided slicing specifies transcripts for Zucchini-dependent, phased piRNA biogenesis
    • Mohn, F., et al. piRNA-guided slicing specifies transcripts for Zucchini-dependent, phased piRNA biogenesis. Science 348 (2015), 812–817.
    • (2015) Science , vol.348 , pp. 812-817
    • Mohn, F.1
  • 74
    • 84940885469 scopus 로고    scopus 로고
    • Slicing and binding by Ago3 or Aub trigger Piwi-bound piRNA production by distinct mechanisms
    • Wang, W., et al. Slicing and binding by Ago3 or Aub trigger Piwi-bound piRNA production by distinct mechanisms. Mol. Cell 59 (2015), 819–830.
    • (2015) Mol. Cell , vol.59 , pp. 819-830
    • Wang, W.1
  • 75
    • 84937517148 scopus 로고    scopus 로고
    • PIWI slicing and RNA elements in precursors instruct directional primary piRNA biogenesis
    • Homolka, D., et al. PIWI slicing and RNA elements in precursors instruct directional primary piRNA biogenesis. Cell Rep. 12 (2015), 418–428.
    • (2015) Cell Rep. , vol.12 , pp. 418-428
    • Homolka, D.1
  • 76
    • 84959440822 scopus 로고    scopus 로고
    • A happy 3′ ending to the piRNA maturation story
    • Czech, B., Hannon, G.J., A happy 3′ ending to the piRNA maturation story. Cell 164 (2016), 838–840.
    • (2016) Cell , vol.164 , pp. 838-840
    • Czech, B.1    Hannon, G.J.2
  • 77
    • 85016163708 scopus 로고    scopus 로고
    • Genetic and mechanistic diversity of piRNA 3′-end formation
    • Hayashi, R., et al. Genetic and mechanistic diversity of piRNA 3′-end formation. Nature 539 (2016), 588–592.
    • (2016) Nature , vol.539 , pp. 588-592
    • Hayashi, R.1
  • 78
    • 80052991624 scopus 로고    scopus 로고
    • 3′ end formation of PIWI-interacting RNAs in vitro
    • Kawaoka, S., et al. 3′ end formation of PIWI-interacting RNAs in vitro. Mol. Cell 43 (2011), 1015–1022.
    • (2011) Mol. Cell , vol.43 , pp. 1015-1022
    • Kawaoka, S.1
  • 79
    • 84927911941 scopus 로고    scopus 로고
    • The exonuclease Nibbler regulates age-associated traits and modulates piRNA length in Drosophila
    • Feltzin, V.L., et al. The exonuclease Nibbler regulates age-associated traits and modulates piRNA length in Drosophila. Aging Cell 14 (2015), 443–452.
    • (2015) Aging Cell , vol.14 , pp. 443-452
    • Feltzin, V.L.1
  • 80
    • 84956676393 scopus 로고    scopus 로고
    • Antagonistic roles of Nibbler and Hen1 in modulating piRNA 3′ ends in Drosophila
    • Wang, H., et al. Antagonistic roles of Nibbler and Hen1 in modulating piRNA 3′ ends in Drosophila. Development 143 (2016), 530–539.
    • (2016) Development , vol.143 , pp. 530-539
    • Wang, H.1
  • 81
    • 34447291602 scopus 로고    scopus 로고
    • The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC
    • Horwich, M.D., et al. The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Curr. Biol. 17 (2007), 1265–1272.
    • (2007) Curr. Biol. , vol.17 , pp. 1265-1272
    • Horwich, M.D.1
  • 82
    • 34347378274 scopus 로고    scopus 로고
    • Pimet, the Drosophila homolog of HEN1, mediates 2′-O-methylation of PIWI-interacting RNAs at their 3′ ends
    • Saito, K., et al. Pimet, the Drosophila homolog of HEN1, mediates 2′-O-methylation of PIWI-interacting RNAs at their 3′ ends. Genes Dev. 21 (2007), 1603–1608.
    • (2007) Genes Dev. , vol.21 , pp. 1603-1608
    • Saito, K.1
  • 83
    • 84878827621 scopus 로고    scopus 로고
    • The genetic makeup of the Drosophila piRNA Pathway
    • Handler, D., et al. The genetic makeup of the Drosophila piRNA Pathway. Mol. Cell 50 (2013), 762–777.
    • (2013) Mol. Cell , vol.50 , pp. 762-777
    • Handler, D.1
  • 84
    • 84878847013 scopus 로고    scopus 로고
    • A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila
    • Muerdter, F., et al. A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila. Mol. Cell 50 (2013), 736–748.
    • (2013) Mol. Cell , vol.50 , pp. 736-748
    • Muerdter, F.1
  • 85
    • 0028913908 scopus 로고
    • Fs(1) Yb is required for ovary follicle cell-differentiation in Drosophila melanogaster and has genetic interactions with the Notch group of neurogenic genes
    • Johnson, E., et al. Fs(1) Yb is required for ovary follicle cell-differentiation in Drosophila melanogaster and has genetic interactions with the Notch group of neurogenic genes. Genetics 140 (1995), 207–217.
    • (1995) Genetics , vol.140 , pp. 207-217
    • Johnson, E.1
  • 86
    • 84860389782 scopus 로고    scopus 로고
    • A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors
    • Handler, D., et al. A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors. EMBO J. 30 (2011), 3977–3993.
    • (2011) EMBO J. , vol.30 , pp. 3977-3993
    • Handler, D.1
  • 87
    • 79952792594 scopus 로고    scopus 로고
    • The Yb body, a major site for Piwi-associated RNA biogenesis and a gateway for Piwi expression and transport to the nucleus in somatic cells
    • Qi, H., et al. The Yb body, a major site for Piwi-associated RNA biogenesis and a gateway for Piwi expression and transport to the nucleus in somatic cells. J. Biol. Chem. 286 (2011), 3789–3797.
    • (2011) J. Biol. Chem. , vol.286 , pp. 3789-3797
    • Qi, H.1
  • 88
    • 80051948751 scopus 로고    scopus 로고
    • Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila
    • Zamparini, A.L., et al. Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila. Development 138 (2011), 4039–4050.
    • (2011) Development , vol.138 , pp. 4039-4050
    • Zamparini, A.L.1
  • 89
    • 84904034861 scopus 로고    scopus 로고
    • Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly
    • Murota, Y., et al. Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly. Cell Rep. 8 (2014), 103–113.
    • (2014) Cell Rep. , vol.8 , pp. 103-113
    • Murota, Y.1
  • 90
    • 78149478349 scopus 로고    scopus 로고
    • Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila
    • Saito, K., et al. Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila. Genes Dev. 24 (2010), 2493–2498.
    • (2010) Genes Dev. , vol.24 , pp. 2493-2498
    • Saito, K.1
  • 91
    • 70349687126 scopus 로고    scopus 로고
    • GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline
    • Ma, L., et al. GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet., 5, 2009, e1000635.
    • (2009) PLoS Genet. , vol.5 , pp. e1000635
    • Ma, L.1
  • 92
    • 84878095917 scopus 로고    scopus 로고
    • GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells
    • Shiromoto, Y., et al. GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells. RNA 19 (2013), 803–810.
    • (2013) RNA , vol.19 , pp. 803-810
    • Shiromoto, Y.1
  • 93
    • 84880668485 scopus 로고    scopus 로고
    • Minotaur is critical for primary piRNA biogenesis
    • Vagin, V.V., et al. Minotaur is critical for primary piRNA biogenesis. RNA 19 (2013), 1064–1077.
    • (2013) RNA , vol.19 , pp. 1064-1077
    • Vagin, V.V.1
  • 94
    • 84855957812 scopus 로고    scopus 로고
    • piRNA pathway and the potential processing site, the nuage, in the Drosophila germline
    • Pek, J.W., et al. piRNA pathway and the potential processing site, the nuage, in the Drosophila germline. Dev. Growth Differ. 54 (2012), 66–77.
    • (2012) Dev. Growth Differ. , vol.54 , pp. 66-77
    • Pek, J.W.1
  • 95
    • 34249849029 scopus 로고    scopus 로고
    • Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster
    • 20143–20143
    • Lim, A.K., Kai, T., Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster. Proc. Natl. Acad. Sci. U. S. A., 104, 2007 20143–20143.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104
    • Lim, A.K.1    Kai, T.2
  • 96
    • 84939480002 scopus 로고    scopus 로고
    • Aub and Ago3 are recruited to nuage through two mechanisms to form a ping-pong complex assembled by Krimper
    • Webster, A., et al. Aub and Ago3 are recruited to nuage through two mechanisms to form a ping-pong complex assembled by Krimper. Mol. Cell 59 (2015), 564–575.
    • (2015) Mol. Cell , vol.59 , pp. 564-575
    • Webster, A.1
  • 97
    • 81355133162 scopus 로고    scopus 로고
    • Heterotypic piRNA ping-pong requires Qin, a protein with both E3 ligase and Tudor domains
    • Zhang, Z., et al. Heterotypic piRNA ping-pong requires Qin, a protein with both E3 ligase and Tudor domains. Mol. Cell 44 (2011), 572–584.
    • (2011) Mol. Cell , vol.44 , pp. 572-584
    • Zhang, Z.1
  • 98
    • 84903175756 scopus 로고    scopus 로고
    • RNA clamping by Vasa assembles a piRNA amplifier complex on transposon transcripts
    • Xiol, J., et al. RNA clamping by Vasa assembles a piRNA amplifier complex on transposon transcripts. Cell 157 (2014), 1698–1711.
    • (2014) Cell , vol.157 , pp. 1698-1711
    • Xiol, J.1
  • 99
    • 84920933929 scopus 로고    scopus 로고
    • Respective functions of two distinct Siwi complexes assembled during PIWI-interacting RNA Biogenesis in Bombyx germ cells
    • Nishida, K.M., et al. Respective functions of two distinct Siwi complexes assembled during PIWI-interacting RNA Biogenesis in Bombyx germ cells. Cell Rep. 10 (2015), 193–203.
    • (2015) Cell Rep. , vol.10 , pp. 193-203
    • Nishida, K.M.1
  • 100
    • 33646017369 scopus 로고    scopus 로고
    • Structural basis for RNA unwinding by the DEAD- box protein Drosophila vasa
    • Sengoku, T., et al. Structural basis for RNA unwinding by the DEAD- box protein Drosophila vasa. Cell 125 (2006), 287–300.
    • (2006) Cell , vol.125 , pp. 287-300
    • Sengoku, T.1
  • 101
    • 84947045999 scopus 로고    scopus 로고
    • The crystal structure of the Drosophila germline inducer Oskar identifies two domains with distinct Vasa helicase- and RNA-binding activities
    • Jeske, M., et al. The crystal structure of the Drosophila germline inducer Oskar identifies two domains with distinct Vasa helicase- and RNA-binding activities. Cell Rep. 12 (2015), 587–598.
    • (2015) Cell Rep. , vol.12 , pp. 587-598
    • Jeske, M.1
  • 102
    • 84981155224 scopus 로고    scopus 로고
    • In vivo mapping of the functional regions of the DEAD-box helicase Vasa
    • Dehghani, M., Lasko, P., In vivo mapping of the functional regions of the DEAD-box helicase Vasa. Biol. Open 4 (2015), 450–U457.
    • (2015) Biol. Open , vol.4 , pp. 450-U457
    • Dehghani, M.1    Lasko, P.2
  • 103
    • 12544255565 scopus 로고    scopus 로고
    • Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha
    • Zeng, Y., et al. Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha. EMBO J. 24 (2005), 138–148.
    • (2005) EMBO J. , vol.24 , pp. 138-148
    • Zeng, Y.1
  • 104
    • 79960185923 scopus 로고    scopus 로고
    • Dicer recognizes the 5′ end of RNA for efficient and accurate processing
    • Park, J.E., et al. Dicer recognizes the 5′ end of RNA for efficient and accurate processing. Nature 475 (2011), 201–205.
    • (2011) Nature , vol.475 , pp. 201-205
    • Park, J.E.1
  • 105
    • 84964678883 scopus 로고    scopus 로고
    • Drosha and Dicer: slicers cut from the same cloth
    • Li, S.S., Patel, D.J., Drosha and Dicer: slicers cut from the same cloth. Cell Res. 26 (2016), 511–512.
    • (2016) Cell Res. , vol.26 , pp. 511-512
    • Li, S.S.1    Patel, D.J.2
  • 106
    • 84055217981 scopus 로고    scopus 로고
    • Production of artificial piRNAs in flies and mice
    • Muerdter, F., et al. Production of artificial piRNAs in flies and mice. RNA 18 (2012), 42–52.
    • (2012) RNA , vol.18 , pp. 42-52
    • Muerdter, F.1
  • 107
    • 84937513694 scopus 로고    scopus 로고
    • Somatic primary piRNA biogenesis driven by cis-acting RNA elements and trans-acting Yb
    • Ishizu, H., et al. Somatic primary piRNA biogenesis driven by cis-acting RNA elements and trans-acting Yb. Cell Rep. 12 (2015), 429–440.
    • (2015) Cell Rep. , vol.12 , pp. 429-440
    • Ishizu, H.1
  • 108
    • 84929380388 scopus 로고    scopus 로고
    • Phased piRNAs tackle transposons
    • Siomi, H., Siomi, M.C., Phased piRNAs tackle transposons. Science 348 (2015), 756–757.
    • (2015) Science , vol.348 , pp. 756-757
    • Siomi, H.1    Siomi, M.C.2
  • 109
    • 4444302947 scopus 로고    scopus 로고
    • Crystal structure of argonaute and its implications for RISC slicer activity
    • Song, J.J., et al. Crystal structure of argonaute and its implications for RISC slicer activity. Science 305 (2004), 1434–1437.
    • (2004) Science , vol.305 , pp. 1434-1437
    • Song, J.J.1
  • 110
    • 84901200904 scopus 로고    scopus 로고
    • Prokaryotic Argonautes defend genomes against invasive DNA
    • Hur, J.K., et al. Prokaryotic Argonautes defend genomes against invasive DNA. Trends Biochem. Sci. 39 (2014), 257–259.
    • (2014) Trends Biochem. Sci. , vol.39 , pp. 257-259
    • Hur, J.K.1
  • 111
    • 84896316351 scopus 로고    scopus 로고
    • DNA-guided DNA interference by a prokaryotic Argonaute
    • Swarts, D.C., et al. DNA-guided DNA interference by a prokaryotic Argonaute. Nature 507 (2014), 258–261.
    • (2014) Nature , vol.507 , pp. 258-261
    • Swarts, D.C.1
  • 112
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein, E., et al. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409 (2001), 363–366.
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1
  • 113
    • 44349084754 scopus 로고    scopus 로고
    • The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs
    • Okamura, K., et al. The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs. Nature 453 (2008), 803–806.
    • (2008) Nature , vol.453 , pp. 803-806
    • Okamura, K.1
  • 114
    • 0141843656 scopus 로고    scopus 로고
    • The nuclear RNase III Drosha initiates microRNA processing
    • Lee, Y., et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 425 (2003), 415–419.
    • (2003) Nature , vol.425 , pp. 415-419
    • Lee, Y.1
  • 115
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • Hutvagner, G., et al. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293 (2001), 834–838.
    • (2001) Science , vol.293 , pp. 834-838
    • Hutvagner, G.1
  • 116
    • 17844364875 scopus 로고    scopus 로고
    • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    • Grishok, A., et al. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106 (2001), 23–34.
    • (2001) Cell , vol.106 , pp. 23-34
    • Grishok, A.1
  • 117
    • 84955323893 scopus 로고    scopus 로고
    • One loop to rule them all: the ping-pong cycle and piRNA-guided silencing
    • Czech, B., Hannon, G.J., One loop to rule them all: the ping-pong cycle and piRNA-guided silencing. Trends Biochem. Sci. 41 (2016), 324–337.
    • (2016) Trends Biochem. Sci. , vol.41 , pp. 324-337
    • Czech, B.1    Hannon, G.J.2
  • 118
    • 84930695555 scopus 로고    scopus 로고
    • PIWI-Interacting RNA: its biogenesis and functions
    • Iwasaki, Y.W., et al. PIWI-Interacting RNA: its biogenesis and functions. Annu. Rev. Biochem. 84 (2015), 405–433.
    • (2015) Annu. Rev. Biochem. , vol.84 , pp. 405-433
    • Iwasaki, Y.W.1
  • 119
    • 85028868970 scopus 로고    scopus 로고
    • Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries
    • Pandey, R.R., et al. Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries. PLoS Genet., 13, 2017, e1006956.
    • (2017) PLoS Genet. , vol.13 , pp. e1006956
    • Pandey, R.R.1
  • 120
    • 85032379061 scopus 로고    scopus 로고
    • Zucchini-dependent piRNA processing is triggered by recruitment to the cytoplasmic processing machinery
    • Rogers, A.K., et al. Zucchini-dependent piRNA processing is triggered by recruitment to the cytoplasmic processing machinery. Genes Dev., 2017, 10.1101/gad.303214.117.
    • (2017) Genes Dev.
    • Rogers, A.K.1


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