메뉴 건너뛰기




Volumn 84, Issue , 2015, Pages 405-433

PIWI-interacting RNA: Its biogenesis and functions

Author keywords

Gene regulation; PiRNA; PIWI proteins; RNA silencing; RNAi; Transposon

Indexed keywords

PIWI INTERACTING RNA; PIWI PROTEIN; ARGONAUTE PROTEIN; SMALL INTERFERING RNA; TRANSPOSON;

EID: 84930695555     PISSN: 00664154     EISSN: 15454509     Source Type: Book Series    
DOI: 10.1146/annurev-biochem-060614-034258     Document Type: Article
Times cited : (528)

References (149)
  • 1
    • 58749096360 scopus 로고    scopus 로고
    • On the road to reading the RNA-interference code
    • Siomi H, Siomi MC. 2009. On the road to reading the RNA-interference code. Nature 457:396-404
    • (2009) Nature , vol.457 , pp. 396-404
    • Siomi, H.1    Siomi, M.C.2
  • 2
    • 58449134534 scopus 로고    scopus 로고
    • Small silencing RNAs: An expanding universe
    • Ghildiyal M, Zamore PD. 2009. Small silencing RNAs: an expanding universe. Nat. Rev. Genet. 10:94-108
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 94-108
    • Ghildiyal, M.1    Zamore, P.D.2
  • 4
    • 34249810892 scopus 로고    scopus 로고
    • Argonaute proteins: Mediators of RNA silencing
    • Peters L, Meister G. 2007. Argonaute proteins: mediators of RNA silencing. Mol. Cell 26:611-23
    • (2007) Mol. Cell , vol.26 , pp. 611-623
    • Peters, L.1    Meister, G.2
  • 5
    • 33746502166 scopus 로고    scopus 로고
    • A distinct small RNA pathway silences selfish genetic elements in the germline
    • Vagin VV, Sigova A, Li C, Seitz H, Gvozdev V, Zamore PD. 2006. A distinct small RNA pathway silences selfish genetic elements in the germline. Science 313:320-24
    • (2006) Science , vol.313 , pp. 320-324
    • Vagin, V.V.1    Sigova, A.2    Li, C.3    Seitz, H.4    Gvozdev, V.5    Zamore, P.D.6
  • 7
    • 58749097426 scopus 로고    scopus 로고
    • Small RNAs in transcriptional gene silencing and genome defence
    • Moazed D. 2009. Small RNAs in transcriptional gene silencing and genome defence. Nature 457:413-20
    • (2009) Nature , vol.457 , pp. 413-420
    • Moazed, D.1
  • 8
    • 60149098474 scopus 로고    scopus 로고
    • Small RNAs as guardians of the genome
    • Malone CD, Hannon GJ. 2009. Small RNAs as guardians of the genome. Cell 136:656-68
    • (2009) Cell , vol.136 , pp. 656-668
    • Malone, C.D.1    Hannon, G.J.2
  • 9
    • 84868589615 scopus 로고    scopus 로고
    • Biology of PIWI-interacting RNAs: New insights into biogenesis and function inside and outside of germlines
    • Ishizu H, Siomi H, Siomi MC. 2012. Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines. Genes Dev. 26:2361-73
    • (2012) Genes Dev. , vol.26 , pp. 2361-2373
    • Ishizu, H.1    Siomi, H.2    Siomi, M.C.3
  • 10
    • 84892599690 scopus 로고    scopus 로고
    • PIWI proteins and PIWI-interacting RNAs in the soma
    • Ross RJ, Weiner MM, Lin H. 2014. PIWI proteins and PIWI-interacting RNAs in the soma. Nature 505:353-59
    • (2014) Nature , vol.505 , pp. 353-359
    • Ross, R.J.1    Weiner, M.M.2    Lin, H.3
  • 11
    • 84896879856 scopus 로고    scopus 로고
    • Small but sturdy: Small RNAs in cellular memory and epigenetics
    • Stuwe E, Toth KF, Aravin AA. 2014. Small but sturdy: small RNAs in cellular memory and epigenetics. Genes Dev. 28:423-31
    • (2014) Genes Dev. , vol.28 , pp. 423-431
    • Stuwe, E.1    Toth, K.F.2    Aravin, A.A.3
  • 12
    • 55249115975 scopus 로고    scopus 로고
    • Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals
    • Grimson A, Srivastava M, Fahey B, Woodcroft BJ, Chiang HR, et al. 2008. Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals. Nature 455:1193-97
    • (2008) Nature , vol.455 , pp. 1193-1197
    • Grimson, A.1    Srivastava, M.2    Fahey, B.3    Woodcroft, B.J.4    Chiang, H.R.5
  • 13
    • 70350238350 scopus 로고    scopus 로고
    • The biogenesis and function of PIWI proteins and piRNAs: Progress and prospect
    • Thomson T, Lin H. 2009. The biogenesis and function of PIWI proteins and piRNAs: progress and prospect. Annu. Rev. Cell Dev. Biol. 25:355-76
    • (2009) Annu. Rev. Cell Dev. Biol. , vol.25 , pp. 355-376
    • Thomson, T.1    Lin, H.2
  • 14
    • 0032443562 scopus 로고    scopus 로고
    • A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal
    • Cox DN, Chao A, Baker J, Chang L, Qiao D, Lin H. 1998. A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal. Genes Dev. 12:3715-27
    • (1998) Genes Dev. , vol.12 , pp. 3715-3727
    • Cox, D.N.1    Chao, A.2    Baker, J.3    Chang, L.4    Qiao, D.5    Lin, H.6
  • 15
    • 65549118489 scopus 로고    scopus 로고
    • Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies
    • Li C, Vagin VV, Lee S, Xu J, Ma S, et al. 2009. Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell 137:509-21
    • (2009) Cell , vol.137 , pp. 509-521
    • Li, C.1    Vagin, V.V.2    Lee, S.3    Xu, J.4    Ma, S.5
  • 16
    • 0032955004 scopus 로고    scopus 로고
    • Genetic and molecular characterization of sting, a gene involved in crystal formation and meiotic drive in the male germ line of Drosophila melanogaster
    • Schmidt A, Palumbo G, Bozzetti MP, Tritto P, Pimpinelli S, Schäfer U. 1999. Genetic and molecular characterization of sting, a gene involved in crystal formation and meiotic drive in the male germ line of Drosophila melanogaster. Genetics 151:749-60
    • (1999) Genetics , vol.151 , pp. 749-760
    • Schmidt, A.1    Palumbo, G.2    Bozzetti, M.P.3    Tritto, P.4    Pimpinelli, S.5    Schäfer, U.6
  • 17
    • 0030755562 scopus 로고    scopus 로고
    • A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary
    • Lin H, Spradling AC. 1997. A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary. Development 124:2463-76
    • (1997) Development , vol.124 , pp. 2463-2476
    • Lin, H.1    Spradling, A.C.2
  • 18
    • 17144417381 scopus 로고    scopus 로고
    • Argonaute protein PIWI controlsmobilization of retrotransposons in the Drosophila male germline
    • Kalmykova AI, Klenov MS, Gvozdev VA. 2005. Argonaute protein PIWI controlsmobilization of retrotransposons in the Drosophila male germline. Nucleic Acids Res. 33:2052-59
    • (2005) Nucleic Acids Res. , vol.33 , pp. 2052-2059
    • Kalmykova, A.I.1    Klenov, M.S.2    Gvozdev, V.A.3
  • 19
    • 39049191279 scopus 로고    scopus 로고
    • The RNA interference proteins and vasa locus are involved in the silencing of retrotransposons in the female germline of Drosophila melanogaster
    • Vagin VV, Klenov MS, Kalmykova AI, Stolyarenko AD, Kotelnikov RN, Gvozdev VA. 2004. The RNA interference proteins and vasa locus are involved in the silencing of retrotransposons in the female germline of Drosophila melanogaster. RNA Biol. 1:54-58
    • (2004) RNA Biol. , vol.1 , pp. 54-58
    • Vagin, V.V.1    Klenov, M.S.2    Kalmykova, A.I.3    Stolyarenko, A.D.4    Kotelnikov, R.N.5    Gvozdev, V.A.6
  • 20
    • 84876859781 scopus 로고    scopus 로고
    • Dogma derailed: The many influences of RNA on the genome
    • Sabin LR, Delas MJ, Hannon GJ. 2013. Dogma derailed: the many influences of RNA on the genome. Mol. Cell 49:783-94
    • (2013) Mol. Cell , vol.49 , pp. 783-794
    • Sabin, L.R.1    Delas, M.J.2    Hannon, G.J.3
  • 21
    • 33947273235 scopus 로고    scopus 로고
    • Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila
    • Brennecke J, Aravin AA, Stark A, Dus M, Kellis M, et al. 2007. Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell 128:1089-103
    • (2007) Cell , vol.128 , pp. 1089-1103
    • Brennecke, J.1    Aravin, A.A.2    Stark, A.3    Dus, M.4    Kellis, M.5
  • 22
    • 33947390781 scopus 로고    scopus 로고
    • A Slicer-mediated mechanism for repeat-associated siRNA 5′ end formation in Drosophila
    • Gunawardane LS, Saito K, Nishida KM, Miyoshi K, Kawamura Y, et al. 2007. A Slicer-mediated mechanism for repeat-associated siRNA 5′ end formation in Drosophila. Science 315:1587-90
    • (2007) Science , vol.315 , pp. 1587-1590
    • Gunawardane, L.S.1    Saito, K.2    Nishida, K.M.3    Miyoshi, K.4    Kawamura, Y.5
  • 23
    • 32044437792 scopus 로고    scopus 로고
    • Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germline
    • Savitsky M, Kwon D, Georgiev P, Kalmykova A, Gvozdev V. 2006. Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germline. Genes Dev. 20:345-54
    • (2006) Genes Dev. , vol.20 , pp. 345-354
    • Savitsky, M.1    Kwon, D.2    Georgiev, P.3    Kalmykova, A.4    Gvozdev, V.5
  • 24
    • 78650706948 scopus 로고    scopus 로고
    • Distinct functions for the Drosophila piRNA pathway in genome maintenance and telomere protection
    • Khurana JS, Xu J, Weng Z, Theurkauf WE. 2010. Distinct functions for the Drosophila piRNA pathway in genome maintenance and telomere protection. PLOS Genet. 6:e1001246
    • (2010) PLOS Genet. , vol.6 , pp. e1001246
    • Khurana, J.S.1    Xu, J.2    Weng, Z.3    Theurkauf, W.E.4
  • 25
    • 0346786214 scopus 로고    scopus 로고
    • Retrotransposons provide an evolutionarily robust non-telomerase mechanism to maintain telomeres
    • Pardue ML, DeBaryshe PG. 2003. Retrotransposons provide an evolutionarily robust non-telomerase mechanism to maintain telomeres. Annu. Rev. Genet. 37:485-511
    • (2003) Annu. Rev. Genet. , vol.37 , pp. 485-511
    • Pardue, M.L.1    Debaryshe, P.G.2
  • 26
    • 33947720638 scopus 로고    scopus 로고
    • MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline
    • Carmell MA, Girard A, van de Kant HJ, Bourc'his D, Bestor TH, et al. 2007. MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev. Cell 12:503-14
    • (2007) Dev. Cell , vol.12 , pp. 503-514
    • Carmell, M.A.1    Girard, A.2    Van De Kant, H.J.3    Bourc'his, D.4    Bestor, T.H.5
  • 27
    • 34248160438 scopus 로고    scopus 로고
    • Developmentally regulated piRNA clusters implicate MILI in transposon control
    • Aravin AA, Sachidanandam R, Girard A, Fejes-Toth K, Hannon GJ. 2007. Developmentally regulated piRNA clusters implicate MILI in transposon control. Science 316:744-47
    • (2007) Science , vol.316 , pp. 744-747
    • Aravin, A.A.1    Sachidanandam, R.2    Girard, A.3    Fejes-Toth, K.4    Hannon, G.J.5
  • 28
    • 41649116098 scopus 로고    scopus 로고
    • DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes
    • Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Totoki Y, Toyoda A, et al. 2008. DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev. 22:908-17
    • (2008) Genes Dev. , vol.22 , pp. 908-917
    • Kuramochi-Miyagawa, S.1    Watanabe, T.2    Gotoh, K.3    Totoki, Y.4    Toyoda, A.5
  • 29
    • 52049098967 scopus 로고    scopus 로고
    • A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice
    • Aravin AA, Sachidanandam R, Bourc'his D, Schaefer C, Pezic D, et al. 2008. A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol. Cell 31:785-99
    • (2008) Mol. Cell , vol.31 , pp. 785-799
    • Aravin, A.A.1    Sachidanandam, R.2    Bourc'his, D.3    Schaefer, C.4    Pezic, D.5
  • 31
    • 33745336617 scopus 로고    scopus 로고
    • A germline-specific class of small RNAs binds mammalian Piwi proteins
    • Girard A, Sachidanandam R, Hannon GJ, Carmell MA. 2006. A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature 442:199-202
    • (2006) Nature , vol.442 , pp. 199-202
    • Girard, A.1    Sachidanandam, R.2    Hannon, G.J.3    Carmell, M.A.4
  • 32
    • 33745621037 scopus 로고    scopus 로고
    • A novel class of small RNAs in mouse spermatogenic cells
    • Grivna ST, Beyret E, Wang Z, Lin H. 2006. A novel class of small RNAs in mouse spermatogenic cells. Genes Dev. 20:1709-14
    • (2006) Genes Dev. , vol.20 , pp. 1709-1714
    • Grivna, S.T.1    Beyret, E.2    Wang, Z.3    Lin, H.4
  • 34
    • 83055193640 scopus 로고    scopus 로고
    • Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing
    • Reuter M, Berninger P, Chuma S, Shah H, Hosokawa M, et al. 2011. Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing. Nature 480:264-67
    • (2011) Nature , vol.480 , pp. 264-267
    • Reuter, M.1    Berninger, P.2    Chuma, S.3    Shah, H.4    Hosokawa, M.5
  • 35
    • 83055180736 scopus 로고    scopus 로고
    • The endonuclease activity of MILI fuels piRNA amplification that silences LINE1 elements
    • De Fazio S, Bartonicek N, Di Giacomo M, Abreu-Goodger C, Sankar A, et al. 2011. The endonuclease activity of MILI fuels piRNA amplification that silences LINE1 elements. Nature 480:259-63
    • (2011) Nature , vol.480 , pp. 259-263
    • De Fazio, S.1    Bartonicek, N.2    Di Giacomo, M.3    Abreu-Goodger, C.4    Sankar, A.5
  • 36
    • 84872385444 scopus 로고    scopus 로고
    • PiRNA-triggered MIWI ubiquitination and removal by APC/C in late spermatogenesis
    • Zhao S, Gou LT, Zhang M, Zu LD, Hua MM, et al. 2013. piRNA-triggered MIWI ubiquitination and removal by APC/C in late spermatogenesis. Dev. Cell 24:13-25
    • (2013) Dev. Cell , vol.24 , pp. 13-25
    • Zhao, S.1    Gou, L.T.2    Zhang, M.3    Zu, L.D.4    Hua, M.M.5
  • 37
    • 33845741236 scopus 로고    scopus 로고
    • Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response
    • Klattenhoff C, Bratu DP, McGinnis-Schultz N, Koppetsch BS, Cook HA, Theurkauf WE. 2007. Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response. Dev. Cell 12:45-55
    • (2007) Dev. Cell , vol.12 , pp. 45-55
    • Klattenhoff, C.1    Bratu, D.P.2    McGinnis-Schultz, N.3    Koppetsch, B.S.4    Cook, H.A.5    Theurkauf, W.E.6
  • 38
    • 84908179136 scopus 로고    scopus 로고
    • Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrommutantmice
    • Castañeda J, Genzor P, van der Heijden GW, Sarkeshik A, Yates JR 3rd, et al. 2014. Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrommutantmice.EMBOJ. 33:1999-2019
    • (2014) EMBOJ , vol.33 , pp. 1999-2019
    • Castañeda, J.1    Genzor, P.2    Van Der Heijden, G.W.3    Sarkeshik, A.4    Yates, J.R.5
  • 39
    • 81755163590 scopus 로고    scopus 로고
    • Separation of stem cell maintenance and transposon silencing functions of Piwi protein
    • Klenov MS, Sokolova OA, Yakushev EY, Stolyarenko AD, Mikhaleva EA, et al. 2011. Separation of stem cell maintenance and transposon silencing functions of Piwi protein. PNAS 108:18760-65
    • (2011) PNAS , vol.108 , pp. 18760-18765
    • Klenov, M.S.1    Sokolova, O.A.2    Yakushev, E.Y.3    Stolyarenko, A.D.4    Mikhaleva, E.A.5
  • 40
    • 52949123906 scopus 로고    scopus 로고
    • Mice deficient for a small cluster of Piwiinteracting RNAs implicate Piwi-interacting RNAs in transposon control
    • Xu M, You Y, Hunsicker P, Hori T, Small C, et al. 2008. Mice deficient for a small cluster of Piwiinteracting RNAs implicate Piwi-interacting RNAs in transposon control. Biol. Reproduct. 79:51-57
    • (2008) Biol. Reproduct , vol.79 , pp. 51-57
    • Xu, M.1    You, Y.2    Hunsicker, P.3    Hori, T.4    Small, C.5
  • 41
    • 0028795178 scopus 로고
    • Flamenco, a gene controlling the gypsy retrovirus of Drosophila melanogaster
    • Prud'homme N, Gans M, Masson M, Terzian C, Bucheton A. 1995. Flamenco, a gene controlling the gypsy retrovirus of Drosophila melanogaster. Genetics 139:697-711
    • (1995) Genetics , vol.139 , pp. 697-711
    • Prud'homme, N.1    Gans, M.2    Masson, M.3    Terzian, C.4    Bucheton, A.5
  • 42
    • 84889667828 scopus 로고    scopus 로고
    • Distribution, evolution, and diversity of retrotransposons at the flamenco locus reflect the regulatory properties of piRNA clusters
    • Zanni V, Eymery A, Coiffet M, Zytnicki M, Luyten I, et al. 2013. Distribution, evolution, and diversity of retrotransposons at the flamenco locus reflect the regulatory properties of piRNA clusters. PNAS 110:19842-47
    • (2013) PNAS , vol.110 , pp. 19842-19847
    • Zanni, V.1    Eymery, A.2    Coiffet, M.3    Zytnicki, M.4    Luyten, I.5
  • 43
    • 84868626090 scopus 로고    scopus 로고
    • Structure and function of Zucchini endoribonuclease in piRNA biogenesis
    • Nishimasu H, Ishizu H, Saito K, Fukuhara S, Kamatani MK, et al. 2012. Structure and function of Zucchini endoribonuclease in piRNA biogenesis. Nature 491:284-87
    • (2012) Nature , vol.491 , pp. 284-287
    • Nishimasu, H.1    Ishizu, H.2    Saito, K.3    Fukuhara, S.4    Kamatani, M.K.5
  • 44
    • 84868613084 scopus 로고    scopus 로고
    • The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis
    • Ipsaro JJ, Haase AD, Knott SR, Joshua-Tor L, Hannon GJ. 2012. The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature 491:279-83
    • (2012) Nature , vol.491 , pp. 279-283
    • Ipsaro, J.J.1    Haase, A.D.2    Knott, S.R.3    Joshua-Tor, L.4    Hannon, G.J.5
  • 45
    • 34249309547 scopus 로고    scopus 로고
    • Zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline
    • Pane A, Wehr K, Schupbach T. 2007. zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline. Dev. Cell 12:851-62
    • (2007) Dev. Cell , vol.12 , pp. 851-862
    • Pane, A.1    Wehr, K.2    Schupbach, T.3
  • 46
    • 78149472020 scopus 로고    scopus 로고
    • Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila
    • Haase AD, Fenoglio S, Muerdter F, Guzzardo PM, Czech B, et al. 2010. Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila. Genes Dev. 24:2499-504
    • (2010) Genes Dev. , vol.24 , pp. 2499-2504
    • Haase, A.D.1    Fenoglio, S.2    Muerdter, F.3    Guzzardo, P.M.4    Czech, B.5
  • 47
    • 78149478349 scopus 로고    scopus 로고
    • Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila
    • Saito K, Ishizu H, Komai M, Kotani H, Kawamura Y, et al. 2010. Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila. Genes Dev. 24:2493-98
    • (2010) Genes Dev. , vol.24 , pp. 2493-2498
    • Saito, K.1    Ishizu, H.2    Komai, M.3    Kotani, H.4    Kawamura, Y.5
  • 48
    • 77957793321 scopus 로고    scopus 로고
    • An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila
    • Olivieri D, Sykora MM, Sachidanandam R, Mechtler K, Brennecke J. 2010. An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. EMBO J. 29:3301-17
    • (2010) EMBO J. , vol.29 , pp. 3301-3317
    • Olivieri, D.1    Sykora, M.M.2    Sachidanandam, R.3    Mechtler, K.4    Brennecke, J.5
  • 49
    • 80051948751 scopus 로고    scopus 로고
    • Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila
    • Zamparini AL, Davis MY, Malone CD, Vieira E, Zavadil J, et al. 2011. Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila. Development 138:4039-50
    • (2011) Development , vol.138 , pp. 4039-4050
    • Zamparini, A.L.1    Davis, M.Y.2    Malone, C.D.3    Vieira, E.4    Zavadil, J.5
  • 50
    • 84860389782 scopus 로고    scopus 로고
    • A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors
    • Handler D, Olivieri D, Novatchkova M, Gruber FS, Meixner K, et al. 2011. A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors. EMBO J. 30:3977-93
    • (2011) EMBO J. , vol.30 , pp. 3977-3993
    • Handler, D.1    Olivieri, D.2    Novatchkova, M.3    Gruber, F.S.4    Meixner, K.5
  • 51
    • 84864042164 scopus 로고    scopus 로고
    • Shutdown is a component of the Drosophila piRNA biogenesis machinery
    • Preall JB, Czech B, Guzzardo PM, Muerdter F, Hannon GJ. 2012. shutdown is a component of the Drosophila piRNA biogenesis machinery. RNA 18:1446-57
    • (2012) RNA , vol.18 , pp. 1446-1457
    • Preall, J.B.1    Czech, B.2    Guzzardo, P.M.3    Muerdter, F.4    Hannon, G.J.5
  • 52
    • 79952792594 scopus 로고    scopus 로고
    • The Yb body, a major site for Piwi-associated RNA biogenesis and a gateway for Piwi expression and transport to the nucleus in somatic cells
    • Qi H, Watanabe T, Ku HY, Liu N, Zhong M, Lin H. 2011. The Yb body, a major site for Piwi-associated RNA biogenesis and a gateway for Piwi expression and transport to the nucleus in somatic cells. J. Biol. Chem. 286:3789-97
    • (2011) J. Biol. Chem. , vol.286 , pp. 3789-3797
    • Qi, H.1    Watanabe, T.2    Ku, H.Y.3    Liu, N.4    Zhong, M.5    Lin, H.6
  • 54
    • 84880668485 scopus 로고    scopus 로고
    • Minotaur is critical for primary piRNA biogenesis
    • Vagin VV, Yu Y, Jankowska A, Luo Y, Wasik KA, et al. 2013. Minotaur is critical for primary piRNA biogenesis. RNA 19:1064-77
    • (2013) RNA , vol.19 , pp. 1064-1077
    • Vagin, V.V.1    Yu, Y.2    Jankowska, A.3    Luo, Y.4    Wasik, K.A.5
  • 55
    • 80052991624 scopus 로고    scopus 로고
    • 3′ end formation of PIWI-interacting RNAs in vitro
    • Kawaoka S, Izumi N, Katsuma S, Tomari Y. 2011. 3′ end formation of PIWI-interacting RNAs in vitro. Mol. Cell 43:1015-22
    • (2011) Mol. Cell , vol.43 , pp. 1015-1022
    • Kawaoka, S.1    Izumi, N.2    Katsuma, S.3    Tomari, Y.4
  • 56
    • 34347378274 scopus 로고    scopus 로고
    • Pimet, the Drosophila homolog of HEN1, mediates 2′-O-methylation of Piwi-interacting RNAs at their 3′ ends
    • Saito K, Sakaguchi Y, Suzuki T, Siomi H, Siomi MC. 2007. Pimet, the Drosophila homolog of HEN1, mediates 2′-O-methylation of Piwi-interacting RNAs at their 3′ ends. Genes Dev. 21:1603-8
    • (2007) Genes Dev. , vol.21 , pp. 1603-1608
    • Saito, K.1    Sakaguchi, Y.2    Suzuki, T.3    Siomi, H.4    Siomi, M.C.5
  • 57
    • 34447291602 scopus 로고    scopus 로고
    • The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC
    • Horwich MD, Li C, Matranga C, Vagin V, Farley G, et al. 2007. The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Curr. Biol. 17:1265-72
    • (2007) Curr. Biol. , vol.17 , pp. 1265-1272
    • Horwich, M.D.1    Li, C.2    Matranga, C.3    Vagin, V.4    Farley, G.5
  • 58
    • 84870060785 scopus 로고    scopus 로고
    • Transcriptional silencing of transposons by Piwi and Maelstrom and its impact on chromatin state and gene expression
    • Sienski G, Donertas D, Brennecke J. 2012. Transcriptional silencing of transposons by Piwi and Maelstrom and its impact on chromatin state and gene expression. Cell 151:964-80
    • (2012) Cell , vol.151 , pp. 964-980
    • Sienski, G.1    Donertas, D.2    Brennecke, J.3
  • 59
    • 84904034861 scopus 로고    scopus 로고
    • Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly
    • Murota Y, Ishizu H, Nakagawa S, Iwasaki YW, Shibata S, et al. 2014. Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly. Cell Rep. 8:103-13
    • (2014) Cell Rep. , vol.8 , pp. 103-113
    • Murota, Y.1    Ishizu, H.2    Nakagawa, S.3    Iwasaki, Y.W.4    Shibata, S.5
  • 60
    • 65549105694 scopus 로고    scopus 로고
    • Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary
    • Malone CD, Brennecke J, Dus M, Stark A, McCombie WR, et al. 2009. Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell 137:522-35
    • (2009) Cell , vol.137 , pp. 522-535
    • Malone, C.D.1    Brennecke, J.2    Dus, M.3    Stark, A.4    McCombie, W.R.5
  • 61
    • 48549092573 scopus 로고    scopus 로고
    • Mousemaelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis
    • Soper SF, van der Heijden GW, Hardiman TC, Goodheart M, Martin SL, et al. 2008. Mousemaelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis. Dev. Cell 15:285-97
    • (2008) Dev. Cell , vol.15 , pp. 285-297
    • Soper, S.F.1    Van Der Heijden, G.W.2    Hardiman, T.C.3    Goodheart, M.4    Martin, S.L.5
  • 62
    • 77955409741 scopus 로고    scopus 로고
    • MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs
    • Frost RJ, Hamra FK, Richardson JA, Qi X, Bassel-Duby R, Olson EN. 2010. MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs. PNAS 107:11847-52
    • (2010) PNAS , vol.107 , pp. 11847-11852
    • Frost, R.J.1    Hamra, F.K.2    Richardson, J.A.3    Qi, X.4    Bassel-Duby, R.5    Olson, E.N.6
  • 63
    • 79952509006 scopus 로고    scopus 로고
    • PiRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling
    • Huang H, Gao Q, Peng X, Choi SY, Sarma K, et al. 2011. piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling. Dev. Cell 20:376-87
    • (2011) Dev. Cell , vol.20 , pp. 376-387
    • Huang, H.1    Gao, Q.2    Peng, X.3    Choi, S.Y.4    Sarma, K.5
  • 64
    • 84866854050 scopus 로고    scopus 로고
    • A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing
    • Xiol J, Cora E, Koglgruber R, Chuma S, Subramanian S, et al. 2012. A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing. Mol. Cell 47:970-79
    • (2012) Mol. Cell , vol.47 , pp. 970-979
    • Xiol, J.1    Cora, E.2    Koglgruber, R.3    Chuma, S.4    Subramanian, S.5
  • 65
    • 79952525007 scopus 로고    scopus 로고
    • MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline
    • Watanabe T, Chuma S, Yamamoto Y, Kuramochi-Miyagawa S, Totoki Y, et al. 2011. MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. Dev. Cell 20:364-75
    • (2011) Dev. Cell , vol.20 , pp. 364-375
    • Watanabe, T.1    Chuma, S.2    Yamamoto, Y.3    Kuramochi-Miyagawa, S.4    Totoki, Y.5
  • 66
    • 77955406478 scopus 로고    scopus 로고
    • Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interactingRNA(piRNA) pathway
    • Zheng K, Xiol J, Reuter M, Eckardt S, Leu NA, et al. 2010. Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interactingRNA(piRNA) pathway. PNAS 107:11841-46
    • (2010) PNAS , vol.107 , pp. 11841-11846
    • Zheng, K.1    Xiol, J.2    Reuter, M.3    Eckardt, S.4    Leu, N.A.5
  • 67
    • 84874230944 scopus 로고    scopus 로고
    • Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state
    • Le Thomas A, Rogers AK, Webster A, Marinov GK, Liao SE, et al. 2013. Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Genes Dev. 27:390-99
    • (2013) Genes Dev. , vol.27 , pp. 390-399
    • Le Thomas, A.1    Rogers, A.K.2    Webster, A.3    Marinov, G.K.4    Liao, S.E.5
  • 68
    • 84862907807 scopus 로고    scopus 로고
    • Drosophila Piwi functions downstream of piRNA production mediating a chromatin-based transposon silencing mechanism in female germ line
    • Wang SH, Elgin SC. 2011. Drosophila Piwi functions downstream of piRNA production mediating a chromatin-based transposon silencing mechanism in female germ line. PNAS 108:21164-69
    • (2011) PNAS , vol.108 , pp. 21164-21169
    • Wang, S.H.1    Elgin, S.C.2
  • 70
    • 84881045635 scopus 로고    scopus 로고
    • DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary
    • Ohtani H, Iwasaki YW, Shibuya A, Siomi H, Siomi MC, Saito K. 2013. DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary. Genes Dev. 27:1656-61
    • (2013) Genes Dev. , vol.27 , pp. 1656-1661
    • Ohtani, H.1    Iwasaki, Y.W.2    Shibuya, A.3    Siomi, H.4    Siomi, M.C.5    Saito, K.6
  • 71
    • 84878847013 scopus 로고    scopus 로고
    • Agenome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila
    • Muerdter F, Guzzardo PM, Gillis J, Luo Y, Yu Y, et al. 2013. Agenome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila. Mol. Cell 50:736-48
    • (2013) Mol. Cell , vol.50 , pp. 736-748
    • Muerdter, F.1    Guzzardo, P.M.2    Gillis, J.3    Luo, Y.4    Yu, Y.5
  • 72
    • 84881081955 scopus 로고    scopus 로고
    • Drosophila Gtsf1 is an essential component of the Piwimediated transcriptional silencing complex
    • Donertas D, Sienski G, Brennecke J. 2013. Drosophila Gtsf1 is an essential component of the Piwimediated transcriptional silencing complex. Genes Dev. 27:1693-705
    • (2013) Genes Dev. , vol.27 , pp. 1693-1705
    • Donertas, D.1    Sienski, G.2    Brennecke, J.3
  • 73
    • 34548822460 scopus 로고    scopus 로고
    • Drosophila PIWI associates with chromatin and interacts directly with HP1a
    • Brower-Toland B, Findley SD, Jiang L, Liu L, Yin H, et al. 2007. Drosophila PIWI associates with chromatin and interacts directly with HP1a. Genes Dev. 21:2300-11
    • (2007) Genes Dev. , vol.21 , pp. 2300-2311
    • Brower-Toland, B.1    Findley, S.D.2    Jiang, L.3    Liu, L.4    Yin, H.5
  • 74
  • 75
    • 84878851966 scopus 로고    scopus 로고
    • A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway
    • Czech B, Preall JB, McGinn J, Hannon GJ. 2013. A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway. Mol. Cell 50:749-61
    • (2013) Mol. Cell , vol.50 , pp. 749-761
    • Czech, B.1    Preall, J.B.2    McGinn, J.3    Hannon, G.J.4
  • 76
    • 34249849029 scopus 로고    scopus 로고
    • Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster
    • Lim AK, Kai T. 2007. Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster. PNAS 104:6714-19
    • (2007) PNAS , vol.104 , pp. 6714-6719
    • Lim, A.K.1    Kai, T.2
  • 78
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • Elbashir SM, Lendeckel W, Tuschl T. 2001. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15:188-200
    • (2001) Genes Dev. , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 79
    • 84903175756 scopus 로고    scopus 로고
    • RNA clamping by vasa assembles a piRNA amplifier complex on transposon transcripts
    • Xiol J, Spinelli P, Laussmann MA, Homolka D, Yang Z, et al. 2014. RNA clamping by vasa assembles a piRNA amplifier complex on transposon transcripts. Cell 157:1698-711
    • (2014) Cell , vol.157 , pp. 1698-1711
    • Xiol, J.1    Spinelli, P.2    Laussmann, M.A.3    Homolka, D.4    Yang, Z.5
  • 80
    • 84920933929 scopus 로고    scopus 로고
    • Respective functions of two distinct Siwi complexes assembled during PIWI-interacting RNA biogenesis in Bombyx germ cells
    • Nishida KM, Iwasaki YW, Murota Y, Nagao A, Mannen T, et al. 2015. Respective functions of two distinct Siwi complexes assembled during PIWI-interacting RNA biogenesis in Bombyx germ cells. Cell Rep. 10:193-203
    • (2015) Cell Rep. , vol.10 , pp. 193-203
    • Nishida, K.M.1    Iwasaki, Y.W.2    Murota, Y.3    Nagao, A.4    Mannen, T.5
  • 82
    • 73949084329 scopus 로고    scopus 로고
    • Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi
    • Chen C, Jin J, James DA, Adams-Cioaba MA, Park JG, et al. 2009. Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. PNAS 106:20336-41
    • (2009) PNAS , vol.106 , pp. 20336-20341
    • Chen, C.1    Jin, J.2    James, D.A.3    Adams-Cioaba, M.A.4    Park, J.G.5
  • 83
    • 67349281394 scopus 로고    scopus 로고
    • Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability
    • Kirino Y, Kim N, de Planell-Saguer M, Khandros E, Chiorean S, et al. 2009. Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability. Nat. Cell Biol. 11:652-58
    • (2009) Nat. Cell Biol. , vol.11 , pp. 652-658
    • Kirino, Y.1    Kim, N.2    De Planell-Saguer, M.3    Khandros, E.4    Chiorean, S.5
  • 84
    • 67349141725 scopus 로고    scopus 로고
    • Loss of the Mili-interacting Tudor domain-containing protein 1 activates transposons and alters the Mili-associated small RNA profile
    • Reuter M, Chuma S, Tanaka T, Franz T, Stark A, Pillai RS. 2009. Loss of the Mili-interacting Tudor domain-containing protein 1 activates transposons and alters the Mili-associated small RNA profile. Nat. Struct. Mol. Biol. 16:639-46
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 639-646
    • Reuter, M.1    Chuma, S.2    Tanaka, T.3    Franz, T.4    Stark, A.5    Pillai, R.S.6
  • 85
    • 72449147419 scopus 로고    scopus 로고
    • Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines
    • Nishida KM, Okada TN, Kawamura T, Mituyama T, Kawamura Y, et al. 2009. Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines. EMBO J. 28:3820-31
    • (2009) EMBO J. , vol.28 , pp. 3820-3831
    • Nishida, K.M.1    Okada, T.N.2    Kawamura, T.3    Mituyama, T.4    Kawamura, Y.5
  • 86
    • 68149164399 scopus 로고    scopus 로고
    • Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members
    • Vagin VV, Wohlschlegel J, Qu J, Jonsson Z, Huang X, et al. 2009. Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev. 23:1749-62
    • (2009) Genes Dev. , vol.23 , pp. 1749-1762
    • Vagin, V.V.1    Wohlschlegel, J.2    Qu, J.3    Jonsson, Z.4    Huang, X.5
  • 87
    • 0033824637 scopus 로고    scopus 로고
    • The shut-down gene of Drosophila melanogaster encodes a novel FK506-binding protein essential for the formation of germline cysts during oogenesis
    • Munn K, Steward R. 2000. The shut-down gene of Drosophila melanogaster encodes a novel FK506-binding protein essential for the formation of germline cysts during oogenesis. Genetics 156:245-56
    • (2000) Genetics , vol.156 , pp. 245-256
    • Munn, K.1    Steward, R.2
  • 88
    • 79955366604 scopus 로고    scopus 로고
    • PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition
    • Liu L, Qi H, Wang J, Lin H. 2011. PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition. Development 138:1863-73
    • (2011) Development , vol.138 , pp. 1863-1873
    • Liu, L.1    Qi, H.2    Wang, J.3    Lin, H.4
  • 89
    • 81355133162 scopus 로고    scopus 로고
    • Heterotypic piRNA ping-pong requires qin, a protein with both E3 ligase and Tudor domains
    • Zhang Z, Xu J, Koppetsch BS, Wang J, Tipping C, et al. 2011. Heterotypic piRNA ping-pong requires qin, a protein with both E3 ligase and Tudor domains. Mol. Cell 44:572-84
    • (2011) Mol. Cell , vol.44 , pp. 572-584
    • Zhang, Z.1    Xu, J.2    Koppetsch, B.S.3    Wang, J.4    Tipping, C.5
  • 90
    • 84857059151 scopus 로고    scopus 로고
    • The Tudor domain protein Kumo is required to assemble the nuage and to generate germline piRNAs in Drosophila
    • Anand A, Kai T. 2012. The Tudor domain protein Kumo is required to assemble the nuage and to generate germline piRNAs in Drosophila. EMBO J. 31:870-82
    • (2012) EMBO J. , vol.31 , pp. 870-882
    • Anand, A.1    Kai, T.2
  • 91
    • 77951288138 scopus 로고    scopus 로고
    • Repression of retroelements in Drosophila germline via piRNA pathway by the Tudor domain protein Tejas
    • Patil VS, Kai T. 2010. Repression of retroelements in Drosophila germline via piRNA pathway by the Tudor domain protein Tejas. Curr. Biol. 20:724-30
    • (2010) Curr. Biol. , vol.20 , pp. 724-730
    • Patil, V.S.1    Kai, T.2
  • 92
    • 84866864333 scopus 로고    scopus 로고
    • The cochaperone shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila
    • Olivieri D, Senti KA, Subramanian S, Sachidanandam R, Brennecke J. 2012. The cochaperone shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila. Mol. Cell 47:954-69
    • (2012) Mol. Cell , vol.47 , pp. 954-969
    • Olivieri, D.1    Senti, K.A.2    Subramanian, S.3    Sachidanandam, R.4    Brennecke, J.5
  • 93
    • 84904499496 scopus 로고    scopus 로고
    • Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate
    • Hirano T, Iwasaki YW, Lin ZY, Imamura M, Seki NM, et al. 2014. Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate. RNA 20:1223-37
    • (2014) RNA , vol.20 , pp. 1223-1237
    • Hirano, T.1    Iwasaki, Y.W.2    Lin, Z.Y.3    Imamura, M.4    Seki, N.M.5
  • 94
    • 84876070120 scopus 로고    scopus 로고
    • An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes
    • Li XZ, Roy CK, Dong X, Bolcun-Filas E, Wang J, et al. 2013. An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Mol. Cell 50:67-81
    • (2013) Mol. Cell , vol.50 , pp. 67-81
    • Li, X.Z.1    Roy, C.K.2    Dong, X.3    Bolcun-Filas, E.4    Wang, J.5
  • 95
    • 84902108866 scopus 로고    scopus 로고
    • The Rhino-Deadlock-Cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila
    • Mohn F, Sienski G, Handler D, Brennecke J. 2014. The Rhino-Deadlock-Cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila. Cell 157:1364-79
    • (2014) Cell , vol.157 , pp. 1364-1379
    • Mohn, F.1    Sienski, G.2    Handler, D.3    Brennecke, J.4
  • 96
    • 84902117162 scopus 로고    scopus 로고
    • The HP1 homolog Rhino anchors a nuclear complex that suppresses piRNA precursor splicing
    • Zhang Z, Wang J, Schultz N, Zhang F, Parhad SS, et al. 2014. The HP1 homolog Rhino anchors a nuclear complex that suppresses piRNA precursor splicing. Cell 157:1353-63
    • (2014) Cell , vol.157 , pp. 1353-1363
    • Zhang, Z.1    Wang, J.2    Schultz, N.3    Zhang, F.4    Parhad, S.S.5
  • 97
    • 69249225196 scopus 로고    scopus 로고
    • The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters
    • Klattenhoff C, Xi H, Li C, Lee S, Xu J, et al. 2009. The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters. Cell 138:1137-49
    • (2009) Cell , vol.138 , pp. 1137-1149
    • Klattenhoff, C.1    Xi, H.2    Li, C.3    Lee, S.4    Xu, J.5
  • 98
    • 84906655373 scopus 로고    scopus 로고
    • PiRNA clusters and open chromatin structure
    • Yamanaka S, Siomi MC, Siomi H. 2014. piRNA clusters and open chromatin structure. Mobile DNA 5:22
    • (2014) Mobile DNA , vol.5 , pp. 22
    • Yamanaka, S.1    Siomi, M.C.2    Siomi, H.3
  • 99
    • 1542513556 scopus 로고    scopus 로고
    • Mobile elements: Drivers of genome evolution
    • Kazazian HH Jr. 2004. Mobile elements: drivers of genome evolution. Science 303:1626-32
    • (2004) Science , vol.303 , pp. 1626-1632
    • Kazazian, H.H.1
  • 100
    • 33847749916 scopus 로고    scopus 로고
    • Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome
    • Bergman CM, Quesneville H, Anxolabehere D, Ashburner M. 2006. Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome. Genome Biol. 7:R112
    • (2006) Genome Biol. , vol.7 , pp. R112
    • Bergman, C.M.1    Quesneville, H.2    Anxolabehere, D.3    Ashburner, M.4
  • 101
    • 84455206395 scopus 로고    scopus 로고
    • Adaptation to P element transposon invasion in Drosophila melanogaster
    • Khurana JS, Wang J, Xu J, Koppetsch BS, Thomson TC, et al. 2011. Adaptation to P element transposon invasion in Drosophila melanogaster. Cell 147:1551-63
    • (2011) Cell , vol.147 , pp. 1551-1563
    • Khurana, J.S.1    Wang, J.2    Xu, J.3    Koppetsch, B.S.4    Thomson, T.C.5
  • 102
    • 0017706803 scopus 로고
    • Hybrid dysgenesis in Drosophila melanogaster: A syndrome of aberrant traits including mutation, sterility and male recombination
    • Kidwell MG, Kidwell JF, Sved JA. 1977. Hybrid dysgenesis in Drosophila melanogaster: a syndrome of aberrant traits including mutation, sterility and male recombination. Genetics 86:813-33
    • (1977) Genetics , vol.86 , pp. 813-833
    • Kidwell, M.G.1    Kidwell, J.F.2    Sved, J.A.3
  • 103
    • 84867064532 scopus 로고    scopus 로고
    • Paramutation in Drosophila linked to emergence of a piRNA-producing locus
    • de Vanssay A, Bouge AL, Boivin A, Hermant C, Teysset L, et al. 2012. Paramutation in Drosophila linked to emergence of a piRNA-producing locus. Nature 490:112-15
    • (2012) Nature , vol.490 , pp. 112-115
    • De Vanssay, A.1    Bouge, A.L.2    Boivin, A.3    Hermant, C.4    Teysset, L.5
  • 104
    • 84905270270 scopus 로고    scopus 로고
    • Transgenerationally inherited piRNAs trigger piRNAbiogenesis by changing the chromatin of piRNAclusters and inducing precursor processing
    • Le Thomas A, Stuwe E, Li S, Du J, Marinov G, et al. 2014. Transgenerationally inherited piRNAs trigger piRNAbiogenesis by changing the chromatin of piRNAclusters and inducing precursor processing. Genes Dev. 28:1667-80
    • (2014) Genes Dev. , vol.28 , pp. 1667-1680
    • Le Thomas, A.1    Stuwe, E.2    Li, S.3    Du, J.4    Marinov, G.5
  • 105
    • 0029915717 scopus 로고    scopus 로고
    • Regulated synthesis, transport and assembly of the Drosophila germ plasm
    • Rongo C, Lehmann R. 1996. Regulated synthesis, transport and assembly of the Drosophila germ plasm. Trends Genet. 12:102-9
    • (1996) Trends Genet. , vol.12 , pp. 102-109
    • Rongo, C.1    Lehmann, R.2
  • 106
    • 33749257862 scopus 로고    scopus 로고
    • The role of PIWI and the miRNA machinery in Drosophila germline determination
    • Megosh HB, Cox DN, Campbell C, Lin H. 2006. The role of PIWI and the miRNA machinery in Drosophila germline determination. Curr. Biol. 16:1884-94
    • (2006) Curr. Biol. , vol.16 , pp. 1884-1894
    • Megosh, H.B.1    Cox, D.N.2    Campbell, C.3    Lin, H.4
  • 108
    • 0037145031 scopus 로고    scopus 로고
    • Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in Tetrahymena
    • Mochizuki K, Fine NA, Fujisawa T, Gorovsky MA. 2002. Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in Tetrahymena. Cell 110:689-99
    • (2002) Cell , vol.110 , pp. 689-699
    • Mochizuki, K.1    Fine, N.A.2    Fujisawa, T.3    Gorovsky, M.A.4
  • 109
    • 80054817896 scopus 로고    scopus 로고
    • DNA rearrangements directed by non-coding RNAs in ciliates
    • Mochizuki K. 2010. DNA rearrangements directed by non-coding RNAs in ciliates. Wiley Interdiscip. Rev. RNA 1:376-87
    • (2010) Wiley Interdiscip. Rev. RNA , vol.1 , pp. 376-387
    • Mochizuki, K.1
  • 110
    • 84870860974 scopus 로고    scopus 로고
    • Piwi-interacting RNAs protect DNA against loss during Oxytricha genome rearrangement
    • Fang W, Wang X, Bracht JR, Nowacki M, Landweber LF. 2012. Piwi-interacting RNAs protect DNA against loss during Oxytricha genome rearrangement. Cell 151:1243-55
    • (2012) Cell , vol.151 , pp. 1243-1255
    • Fang, W.1    Wang, X.2    Bracht, J.R.3    Nowacki, M.4    Landweber, L.F.5
  • 111
    • 33845436047 scopus 로고    scopus 로고
    • Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. Elegans
    • Ruby JG, Jan C, Player C, Axtell MJ, Lee W, et al. 2006. Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. Elegans. Cell 127:1193-207
    • (2006) Cell , vol.127 , pp. 1193-1207
    • Ruby, J.G.1    Jan, C.2    Player, C.3    Axtell, M.J.4    Lee, W.5
  • 112
    • 46149114866 scopus 로고    scopus 로고
    • PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. Elegans
    • Batista PJ, Ruby JG, Claycomb JM, Chiang R, Fahlgren N, et al. 2008. PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. Elegans. Mol. Cell 31:67-78
    • (2008) Mol. Cell , vol.31 , pp. 67-78
    • Batista, P.J.1    Ruby, J.G.2    Claycomb, J.M.3    Chiang, R.4    Fahlgren, N.5
  • 113
    • 46149092009 scopus 로고    scopus 로고
    • Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline
    • Das PP, Bagijn MP, Goldstein LD, Woolford JR, Lehrbach NJ, et al. 2008. Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline. Mol. Cell 31:79-90
    • (2008) Mol. Cell , vol.31 , pp. 79-90
    • Das, P.P.1    Bagijn, M.P.2    Goldstein, L.D.3    Woolford, J.R.4    Lehrbach, N.J.5
  • 114
    • 45449118682 scopus 로고    scopus 로고
    • A C. Elegans Piwi, PRG-1, regulates 21U-RNAs during spermatogenesis
    • Wang G, Reinke V. 2008. A C. Elegans Piwi, PRG-1, regulates 21U-RNAs during spermatogenesis. Curr. Biol. 18:861-67
    • (2008) Curr. Biol. , vol.18 , pp. 861-867
    • Wang, G.1    Reinke, V.2
  • 115
  • 116
    • 84898926413 scopus 로고    scopus 로고
    • A genome-wide RNAi screen identifies factors required for distinct stages of C. Elegans piRNA biogenesis
    • Goh WS, Seah JW, Harrison EJ, Chen C, Hammell CM, Hannon GJ. 2014. A genome-wide RNAi screen identifies factors required for distinct stages of C. Elegans piRNA biogenesis. Genes Dev. 28:797-807
    • (2014) Genes Dev. , vol.28 , pp. 797-807
    • Goh, W.S.1    Seah, J.W.2    Harrison, E.J.3    Chen, C.4    Hammell, C.M.5    Hannon, G.J.6
  • 117
    • 84898882755 scopus 로고    scopus 로고
    • PRDE-1 is a nuclear factor essential for the biogenesis of Ruby motif-dependent piRNAs in C. Elegans
    • Weick EM, Sarkies P, Silva N, Chen RA, Moss SM, et al. 2014. PRDE-1 is a nuclear factor essential for the biogenesis of Ruby motif-dependent piRNAs in C. Elegans. Genes Dev. 28:783-96
    • (2014) Genes Dev. , vol.28 , pp. 783-796
    • Weick, E.M.1    Sarkies, P.2    Silva, N.3    Chen, R.A.4    Moss, S.M.5
  • 120
    • 84863624978 scopus 로고    scopus 로고
    • C. Elegans piRNAs mediate the genome-wide surveillance of germline transcripts
    • Lee HC, Gu W, Shirayama M, Youngman E, Conte D Jr, Mello CC. 2012. C. Elegans piRNAs mediate the genome-wide surveillance of germline transcripts. Cell 150:78-87
    • (2012) Cell , vol.150 , pp. 78-87
    • Lee, H.C.1    Gu, W.2    Shirayama, M.3    Youngman, E.4    Conte, D.5    Mello, C.C.6
  • 121
    • 84863631177 scopus 로고    scopus 로고
    • PiRNAs initiate an epigenetic memory of nonself RNA in the C. Elegans germline
    • Shirayama M, Seth M, Lee HC, Gu W, Ishidate T, et al. 2012. piRNAs initiate an epigenetic memory of nonself RNA in the C. Elegans germline. Cell 150:65-77
    • (2012) Cell , vol.150 , pp. 65-77
    • Shirayama, M.1    Seth, M.2    Lee, H.C.3    Gu, W.4    Ishidate, T.5
  • 122
    • 84890860526 scopus 로고    scopus 로고
    • Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. Elegans
    • Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D Jr, et al. 2013. Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. Elegans. Cell 155:1532-44
    • (2013) Cell , vol.155 , pp. 1532-1544
    • Conine, C.C.1    Moresco, J.J.2    Gu, W.3    Shirayama, M.4    Conte, D.5
  • 123
    • 84890818459 scopus 로고    scopus 로고
    • The C. Elegans CSR-1 Argonaute pathway counteracts epigenetic silencing to promote germline gene expression
    • Seth M, Shirayama M, Gu W, Ishidate T, Conte D Jr, Mello CC. 2013. The C. Elegans CSR-1 Argonaute pathway counteracts epigenetic silencing to promote germline gene expression. Dev. Cell 27:656-63
    • (2013) Dev. Cell , vol.27 , pp. 656-663
    • Seth, M.1    Shirayama, M.2    Gu, W.3    Ishidate, T.4    Conte, D.5    Mello, C.C.6
  • 124
    • 84890836064 scopus 로고    scopus 로고
    • Protection of germline gene expression by the C. Elegans Argonaute CSR-1
    • Wedeles CJ, Wu MZ, Claycomb JM. 2013. Protection of germline gene expression by the C. Elegans Argonaute CSR-1. Dev. Cell 27:664-71
    • (2013) Dev. Cell , vol.27 , pp. 664-671
    • Wedeles, C.J.1    Wu, M.Z.2    Claycomb, J.M.3
  • 125
    • 84863611417 scopus 로고    scopus 로고
    • PiRNAs can trigger a multigenerational epigenetic memory in the germline of C. Elegans
    • Ashe A, Sapetschnig A, Weick EM, Mitchell J, Bagijn MP, et al. 2012. piRNAs can trigger a multigenerational epigenetic memory in the germline of C. Elegans. Cell 150:88-99
    • (2012) Cell , vol.150 , pp. 88-99
    • Ashe, A.1    Sapetschnig, A.2    Weick, E.M.3    Mitchell, J.4    Bagijn, M.P.5
  • 127
    • 0035838369 scopus 로고    scopus 로고
    • Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. Melanogaster germline
    • Aravin AA, Naumova NM, Tulin AV, Vagin VV, Rozovsky YM, Gvozdev VA. 2001. Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline. Curr. Biol. 11:1017-27
    • (2001) Curr. Biol. , vol.11 , pp. 1017-1027
    • Aravin, A.A.1    Naumova, N.M.2    Tulin, A.V.3    Vagin, V.V.4    Rozovsky, Y.M.5    Gvozdev, V.A.6
  • 128
    • 35548991887 scopus 로고    scopus 로고
    • Gene silencing mechanisms mediated by Aubergine piRNA complexes in Drosophila male gonad
    • Nishida KM, Saito K, Mori T, Kawamura Y, Nagami-Okada T, et al. 2007. Gene silencing mechanisms mediated by Aubergine piRNA complexes in Drosophila male gonad. RNA 13:1911-22
    • (2007) RNA , vol.13 , pp. 1911-1922
    • Nishida, K.M.1    Saito, K.2    Mori, T.3    Kawamura, Y.4    Nagami-Okada, T.5
  • 129
    • 78649662103 scopus 로고    scopus 로고
    • Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis
    • Nagao A, Mituyama T, Huang H, Chen D, Siomi MC, Siomi H. 2010. Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis. RNA 16:2503-15
    • (2010) RNA , vol.16 , pp. 2503-2515
    • Nagao, A.1    Mituyama, T.2    Huang, H.3    Chen, D.4    Siomi, M.C.5    Siomi, H.6
  • 130
    • 78049387387 scopus 로고    scopus 로고
    • Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo
    • Rouget C, Papin C, Boureux A, Meunier AC, Franco B, et al. 2010. Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. Nature 467:1128-32
    • (2010) Nature , vol.467 , pp. 1128-1132
    • Rouget, C.1    Papin, C.2    Boureux, A.3    Meunier, A.C.4    Franco, B.5
  • 131
    • 72649094955 scopus 로고    scopus 로고
    • A broadly conserved pathway generates 3′UTR-directed primary piRNAs
    • Robine N, Lau NC, Balla S, Jin Z, Okamura K, et al. 2009. A broadly conserved pathway generates 3′UTR-directed primary piRNAs. Curr. Biol. 19:2066-76
    • (2009) Curr. Biol. , vol.19 , pp. 2066-2076
    • Robine, N.1    Lau, N.C.2    Balla, S.3    Jin, Z.4    Okamura, K.5
  • 132
    • 70449519397 scopus 로고    scopus 로고
    • A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila
    • Saito K, Inagaki S, Mituyama T, Kawamura Y, Ono Y, et al. 2009. A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila. Nature 461:1296-99
    • (2009) Nature , vol.461 , pp. 1296-1299
    • Saito, K.1    Inagaki, S.2    Mituyama, T.3    Kawamura, Y.4    Ono, Y.5
  • 133
    • 84901826810 scopus 로고    scopus 로고
    • Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis
    • Gou LT, Dai P, Yang JH, Xue Y, Hu YP, et al. 2014. Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis. Cell Res. 24:680-700
    • (2014) Cell Res. , vol.24 , pp. 680-700
    • Gou, L.T.1    Dai, P.2    Yang, J.H.3    Xue, Y.4    Hu, Y.P.5
  • 134
    • 79956052873 scopus 로고    scopus 로고
    • Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus
    • Watanabe T, Tomizawa S, Mitsuya K, Totoki Y, Yamamoto Y, et al. 2011. Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science 332:848-52
    • (2011) Science , vol.332 , pp. 848-852
    • Watanabe, T.1    Tomizawa, S.2    Mitsuya, K.3    Totoki, Y.4    Yamamoto, Y.5
  • 136
    • 84901250298 scopus 로고    scopus 로고
    • Genome-defence small RNAs exapted for epigenetic mating-type inheritance
    • Singh DP, Saudemont B, Guglielmi G, Arnaiz O, Gout JF, et al. 2014. Genome-defence small RNAs exapted for epigenetic mating-type inheritance. Nature 509:447-52
    • (2014) Nature , vol.509 , pp. 447-452
    • Singh, D.P.1    Saudemont, B.2    Guglielmi, G.3    Arnaiz, O.4    Gout, J.F.5
  • 137
    • 84901683587 scopus 로고    scopus 로고
    • A single female-specific piRNA is the primary determiner of sex in the silkworm
    • Kiuchi T, Koga H, Kawamoto M, Shoji K, Sakai H, et al. 2014. A single female-specific piRNA is the primary determiner of sex in the silkworm. Nature 509:633-36
    • (2014) Nature , vol.509 , pp. 633-636
    • Kiuchi, T.1    Koga, H.2    Kawamoto, M.3    Shoji, K.4    Sakai, H.5
  • 138
    • 84860320656 scopus 로고    scopus 로고
    • A role for neuronal piRNAs in the epigenetic control of memory-related synaptic plasticity
    • Rajasethupathy P, Antonov I, Sheridan R, Frey S, Sander C, et al. 2012. A role for neuronal piRNAs in the epigenetic control of memory-related synaptic plasticity. Cell 149:693-707
    • (2012) Cell , vol.149 , pp. 693-707
    • Rajasethupathy, P.1    Antonov, I.2    Sheridan, R.3    Frey, S.4    Sander, C.5
  • 139
    • 79956204469 scopus 로고    scopus 로고
    • Identification of piRNAs in the central nervous system
    • Lee EJ, Banerjee S, Zhou H, Jammalamadaka A, Arcila M, et al. 2011. Identification of piRNAs in the central nervous system. RNA 17:1090-99
    • (2011) RNA , vol.17 , pp. 1090-1099
    • Lee, E.J.1    Banerjee, S.2    Zhou, H.3    Jammalamadaka, A.4    Arcila, M.5
  • 140
    • 77955510261 scopus 로고    scopus 로고
    • Piwi positive cells that line the vasculature epithelium, underlie whole body regeneration in a basal chordate
    • Rinkevich Y, Rosner A, Rabinowitz C, Lapidot Z, Moiseeva E, Rinkevich B. 2010. Piwi positive cells that line the vasculature epithelium, underlie whole body regeneration in a basal chordate. Dev. Biol. 345:94-104
    • (2010) Dev. Biol. , vol.345 , pp. 94-104
    • Rinkevich, Y.1    Rosner, A.2    Rabinowitz, C.3    Lapidot, Z.4    Moiseeva, E.5    Rinkevich, B.6
  • 141
    • 84872400676 scopus 로고    scopus 로고
    • Repeated, long-term cycling of putative stem cells between niches in a basal chordate
    • Rinkevich Y, Voskoboynik A, Rosner A, Rabinowitz C, Paz G, et al. 2013. Repeated, long-term cycling of putative stem cells between niches in a basal chordate. Dev. Cell 24:76-88
    • (2013) Dev. Cell , vol.24 , pp. 76-88
    • Rinkevich, Y.1    Voskoboynik, A.2    Rosner, A.3    Rabinowitz, C.4    Paz, G.5
  • 142
    • 78650631610 scopus 로고    scopus 로고
    • Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila
    • Janic A, Mendizabal L, Llamazares S, Rossell D, Gonzalez C. 2010. Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila. Science 330:1824-27
    • (2010) Science , vol.330 , pp. 1824-1827
    • Janic, A.1    Mendizabal, L.2    Llamazares, S.3    Rossell, D.4    Gonzalez, C.5
  • 143
    • 0037030522 scopus 로고    scopus 로고
    • Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas
    • Qiao D, Zeeman AM, Deng W, Looijenga LH, Lin H. 2002. Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas. Oncogene 21:3988-99
    • (2002) Oncogene , vol.21 , pp. 3988-3999
    • Qiao, D.1    Zeeman, A.M.2    Deng, W.3    Looijenga, L.H.4    Lin, H.5
  • 144
    • 84876110299 scopus 로고    scopus 로고
    • PIWI expression and function in cancer
    • Suzuki R, Honda S, Kirino Y. 2012. PIWI expression and function in cancer. Front. Genet. 3:204
    • (2012) Front. Genet. , vol.3 , pp. 204
    • Suzuki, R.1    Honda, S.2    Kirino, Y.3
  • 145
    • 31144460828 scopus 로고    scopus 로고
    • Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway
    • Lee JH, Schutte D, Wulf G, Fuzesi L, Radzun HJ, et al. 2006. Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway. Hum. Mol. Genet. 15:201-11
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 201-211
    • Lee, J.H.1    Schutte, D.2    Wulf, G.3    Fuzesi, L.4    Radzun, H.J.5
  • 146
    • 80855165387 scopus 로고    scopus 로고
    • Genome sequencing reveals insights into physiology and longevity of the naked mole rat
    • Kim EB, Fang X, Fushan AA, Huang Z, Lobanov AV, et al. 2011. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature 479:223-27
    • (2011) Nature , vol.479 , pp. 223-227
    • Kim, E.B.1    Fang, X.2    Fushan, A.A.3    Huang, Z.4    Lobanov, A.V.5
  • 147
    • 78951486816 scopus 로고    scopus 로고
    • Endocrine function and neurobiology of the longest-living rodent, the naked mole-rat
    • Edrey YH, Park TJ, Kang H, Biney A, Buffenstein R. 2011. Endocrine function and neurobiology of the longest-living rodent, the naked mole-rat. Exp. Gerontol. 46:116-23
    • (2011) Exp. Gerontol , vol.46 , pp. 116-123
    • Edrey, Y.H.1    Park, T.J.2    Kang, H.3    Biney, A.4    Buffenstein, R.5
  • 148
    • 84855297335 scopus 로고    scopus 로고
    • A decade of 3C technologies: Insights into nuclear organization
    • de Wit E, de Laat W. 2012. A decade of 3C technologies: insights into nuclear organization. Genes Dev. 26:11-24
    • (2012) Genes Dev. , vol.26 , pp. 11-24
    • De Wit, E.1    De Laat, W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.