Prokaryotic Argonautes defend genomes against invasive DNA

Trends in Biochemical Sciences

Volumn 39, Issue 6, 2014, Pages 257-259

  Hur, Junho K ^a   Olovnikov, Ivan ^a,b   Aravin, Alexei A ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ARGONAUTE PROTEIN; DEOXYCYTIDINE; DNA; ENDONUCLEASE; MICRORNA; PIWI INTERACTING RNA; PLASMID DNA; RNA INDUCED SILENCING COMPLEX; SINGLE STRANDED DNA; SMALL INTERFERING RNA; URIDINE;

5' UNTRANSLATED REGION; AGO GENE; AQUIFEX AEOLICUS; CHROMATIN; DNA CLEAVAGE; ENZYME ACTIVITY; EUKARYOTE; GENE LOCUS; GENE REPRESSION; GENE SILENCING; GENE TARGETING; GENETIC ASSOCIATION; GENOME; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROKARYOTE; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROCESSING; PYROCOCCUS FURIOSUS; RHODOBACTER SPHAEROIDES; RNA INTERFERENCE; SEQUENCE ANALYSIS; SHORT SURVEY; THERMUS THERMOPHILUS; TRANSCRIPTION REGULATION; TRANSPOSON; ANIMAL; GENETICS; HUMAN; INFECTION; METABOLISM; PHYSIOLOGY; PROKARYOTIC CELL;

ANIMALS; ARGONAUTE PROTEINS; DNA; GENOME; HUMANS; INFECTION; PROKARYOTIC CELLS; RNA INTERFERENCE;

EID: 84901200904     PISSN: 09680004     EISSN: 13624326     Source Type: Journal    
DOI: 10.1016/j.tibs.2014.04.006     Document Type: Short Survey

References (10)

1. Carthew R.W., Sontheimer E.J. Origins and Mechanisms of miRNAs and siRNAs. Cell 2009, 136:642-655.
2. Bartel D.P. MicroRNAs: target recognition and regulatory functions. Cell 2009, 136:215-233.
3. Malone C.D., Hannon G.J. Small RNAs as guardians of the genome. Cell 2009, 136:656-668.
4. Stuwe E., et al. Small but sturdy: small RNAs in cellular memory and epigenetics. Genes Dev. 2014, 28:423-431.
5. Makarova K.S., et al. Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements. Biol. Direct 2009, 4:29.
6. Song J.J., et al. Crystal structure of Argonaute and its implications for RISC slicer activity. Science 2004, 305:1434-1437.
7. Yuan Y.R., et al. Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol. Cell 2005, 19:405-419.
8. Olovnikov I., et al. Bacterial argonaute samples the transcriptome to identify foreign DNA. Mol. Cell 2013, 51:594-605.
9. Swarts D.C., et al. DNA-guided DNA interference by a prokaryotic Argonaute. Nature 2014, 507:258-261.
10. Wiedenheft B., et al. RNA-guided genetic silencing systems in bacteria and archaea. Nature 2012, 482:331-338.