TREX is a conserved complex coupling transcription with messenger RNA export

Nature

Volumn 417, Issue 6886, 2002, Pages 304-308

  Stäßer, Katja ^a   Masuda, Seiji ^b   Mason, Paul ^b   Pfannstiel, Jens ^a   Oppizzi, Marisa ^a   Rodriguez Navarro, Susana ^a   Rondón, Ana G ^c   Aguilera, Andres ^c   Struhl, Kevin ^b   Reed, Robin ^b   Hurt, Ed ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF SEVILLE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; PROTEINS; STOICHIOMETRY; YEAST;

SPLICING;

RNA;

GENE PRODUCT; MESSENGER RNA; PROTEIN HPR1; PROTEIN MFT1; PROTEIN SUB2; PROTEIN THO2; PROTEIN THP2; PROTEIN TREX; PROTEIN YRA1; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; GENE ACTIVATION; GENE INTERACTION; GENETIC TRANSCRIPTION; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; STOICHIOMETRY; TRANSCRIPTION REGULATION; YEAST;

ADENOSINE TRIPHOSPHATASES; BIOLOGICAL TRANSPORT; CHROMATIN; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; EPISTASIS, GENETIC; FUNGAL PROTEINS; GENES, FUNGAL; GENES, LETHAL; HUMANS; MACROMOLECULAR SUBSTANCES; NUCLEAR PROTEINS; PROTEIN BINDING; RNA, FUNGAL; RNA, MESSENGER; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

METAZOA;

EID: 0037118052     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature746     Document Type: Article

References (25)

1. Yralp, a conserved nuclear RNA binding protein, interacts directly with Mex67p and is required for mRNA export
2. REF, an evolutionarily conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export
3. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
4. The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila
5. The DECD box putative ATPase Sub 2p is an early mRNA export factor
6. Pre-mRNA splicing and mRNA export linked by direct interactions between UAPS 6 and Aly
7. Splicing factor Sub 2p is required for nuclear export through its interaction with Yralp
8. A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp 2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae
9. The yeast HPRI gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability
10. A novel yeast gene, THO2, is involved in RNA poi II transcription and provides new evidence for transcriptional elongation-associated recombination
11. RLR1 (THO2), required for expressing lacZ fusions in yeast, is conserved from yeast to humans and is a suppressor of SIN 4
12. A generic protein purification method for protein complex characterization and proteome exploration
13. A complex containing RNA polymerase 11, Paf1p, Cdc73p, Hpr1p, and Ccr 4p plays a role in protein kinase C signalling
14. High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability
15. THIS enhances transcriptional elongation through an artificial arrest site in vivo
16. The yeast HRS 1 gene is involved in positive and negative regulation of transcription and shows genetic characteristics similar to SIN4 and GAL11
17. A conserved mRNA export machinery coupled to pre-mRNA splicing
18. The Saccharomyces cerevisiae hyperrecombination mutant hpr1Δ is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA
19. U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction
20. Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for Sub 2, an essential spliceosomal ATPase
21. Multiple roles for the yeast SUB2/yUAP 56 gene in splicing
22. Identification and characterization of yUAP/Sub2p, a yeast homolog of the essential human pre-mRNA splicing factor hUAP 56
23. Messenger RNAs are recruited for nuclear export during transcription
24. Identification of a 60S pre-ribosomal particle that is closely linked to nuclear export
25. Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme