An epigenetic role for maternally inherited piRNAs in transposon silencing

Science

Volumn 322, Issue 5906, 2008, Pages 1387-1392

  Brennecke, Julius ^a   Malone, Colin D ^a   Aravin, Alexei A ^a   Sachidanandam, Ravi ^a,d   Stark, Alexander ^b,c   Hannon, Gregory J ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b HARVARD UNIVERSITY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; PIWI INTERACTING RNA; RNA; UNCLASSIFIED DRUG;

FERTILITY; FERTILIZATION (REPRODUCTION); MATERNAL EFFECT; RNA;

ARTICLE; DROSOPHILA; EPIGENETICS; FERTILITY; GENE SILENCING; HYBRID DYSGENESIS; INFERTILITY; INHERITANCE; METHYLATION; MOTHER; NONHUMAN; OVARY; PRIORITY JOURNAL; PROGENY; TRANSPOSON;

ANIMALS; CROSSES, GENETIC; DNA TRANSPOSABLE ELEMENTS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EPIGENESIS, GENETIC; FEMALE; FERTILITY; HYBRIDIZATION, GENETIC; MALE; OVARY; PEPTIDE INITIATION FACTORS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

MAMMALIA;

EID: 57149104113     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1165171     Document Type: Article

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30. We thank M. Rooks and D. McCombie (CSHL) for help with deep sequencing, S. Jensen and S. Ronsseray for fly stocks and helpful discussions, and D. Finnegan for the I-element ORF-1 antibody. J.B. is supported by a fellowship from The Ernst Schering Foundation, C.D.M. is a Beckman fellow of the Watson School of Biological Sciences and is supported by an NSF Graduate Research Fellowship, and A.S. is supported by a Human Frontier Science Program fellowship. This work was supported by grants from NIH to G.J.H. and A.A.A. and a kind gift from K. W. Davis (to G.J.H.). Small RNA libraries are deposited at Gene Expression Omnibus (accession no. GSE13081, data sets GSM327620 to GSM327634).