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Volumn 8, Issue 6, 2017, Pages 591-605

Anti-angiogenic agents for the treatment of solid tumors: Potential pathways, therapy and current strategies – A review

Author keywords

Angiogenesis inhibitors; Natural products; Receptor protein tyrosine kinase; Tumor microenvironment

Indexed keywords


EID: 85026651730     PISSN: 20901232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jare.2017.06.006     Document Type: Review
Times cited : (159)

References (201)
  • 2
    • 85026646307 scopus 로고    scopus 로고
    • 1950 mortality data – CDC/NCHS, NVSS, mortality Revised. 2002 mortality Data-NVSR-Death final Data 2002-Volume 53, No. 5. Cost data from American Cancer Society Cancer & Figures 2005
    • mortality data – CDC/NCHS, NVSS, mortality Revised. 2002 mortality Data-NVSR-Death final Data 2002-Volume 53, No. 5. Cost data from American Cancer Society Cancer & Figures 2005; 2002.
    • (2002)
  • 6
    • 84932616956 scopus 로고    scopus 로고
    • Targeting angiogenesis in cancer therapy: moving beyond vascular endothelial growth factor
    • Zhao, Y., Adjei, A.A., Targeting angiogenesis in cancer therapy: moving beyond vascular endothelial growth factor. Oncologist 20:6 (2015), 660–673.
    • (2015) Oncologist , vol.20 , Issue.6 , pp. 660-673
    • Zhao, Y.1    Adjei, A.A.2
  • 9
    • 84957539566 scopus 로고    scopus 로고
    • John Hunter and the origin of the term “angiogenesis”
    • Lenzi, P., Bocci, G., Natale, G., John Hunter and the origin of the term “angiogenesis”. Angiogenesis 19:2 (2016), 255–256.
    • (2016) Angiogenesis , vol.19 , Issue.2 , pp. 255-256
    • Lenzi, P.1    Bocci, G.2    Natale, G.3
  • 10
    • 0026781082 scopus 로고
    • Control of angiogenesis by heparin and other sulfated polysaccharides. Heparin and related polysaccharides
    • Folkman, J., Shing, Y., Control of angiogenesis by heparin and other sulfated polysaccharides. Heparin and related polysaccharides. Adv Exp Med Biol 313 (1992), 355–364.
    • (1992) Adv Exp Med Biol , vol.313 , pp. 355-364
    • Folkman, J.1    Shing, Y.2
  • 11
    • 63649138023 scopus 로고    scopus 로고
    • Arterial–venous specification during development
    • Swift, M.R., Weinstein, B.M., Arterial–venous specification during development. Circ Res 104:5 (2009), 576–588.
    • (2009) Circ Res , vol.104 , Issue.5 , pp. 576-588
    • Swift, M.R.1    Weinstein, B.M.2
  • 12
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan, D., Folkman, J., Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86:3 (1996), 353–364.
    • (1996) Cell , vol.86 , Issue.3 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 13
    • 0015311426 scopus 로고
    • Anti-angiogenesis: new concept for therapy of solid tumors
    • Folkman, J., Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg 175:3 (1972), 409–416.
    • (1972) Ann Surg , vol.175 , Issue.3 , pp. 409-416
    • Folkman, J.1
  • 14
    • 84992656231 scopus 로고    scopus 로고
    • Antiangiogenic cancer treatment: the great discovery and greater complexity (Review)
    • Maj, E., Papiernik, D., Wietrzyk, J., Antiangiogenic cancer treatment: the great discovery and greater complexity (Review). Int J Oncol 49:5 (2016), 1773–1784.
    • (2016) Int J Oncol , vol.49 , Issue.5 , pp. 1773-1784
    • Maj, E.1    Papiernik, D.2    Wietrzyk, J.3
  • 15
    • 70549112270 scopus 로고    scopus 로고
    • The angiogenic switch in carcinogenesis.
    • Baeriswyl V, Christofori G, editors. The angiogenic switch in carcinogenesis. Semin Cancer Biol 2009;19(5):329–37.
    • (2009) Semin Cancer Biol , vol.19 , Issue.5 , pp. 329-37
    • Baeriswyl, V.1    Christofori, G.2
  • 16
    • 84926646150 scopus 로고    scopus 로고
    • Common responses of tumors and wounds to hypoxia
    • Payen, V.L., Brisson, L., Dewhirst, M.W., Sonveaux, P., Common responses of tumors and wounds to hypoxia. Cancer J 21:2 (2015), 75–87.
    • (2015) Cancer J , vol.21 , Issue.2 , pp. 75-87
    • Payen, V.L.1    Brisson, L.2    Dewhirst, M.W.3    Sonveaux, P.4
  • 17
    • 84976363133 scopus 로고    scopus 로고
    • Hypoxia-inducible factor as an angiogenic master switch
    • Hashimoto, T., Shibasaki, F., Hypoxia-inducible factor as an angiogenic master switch. Front Pediatr, 3, 2015, 33.
    • (2015) Front Pediatr , vol.3 , pp. 33
    • Hashimoto, T.1    Shibasaki, F.2
  • 19
    • 84942113438 scopus 로고    scopus 로고
    • Endothelial progenitor cells in sprouting angiogenesis: proteases pave the way
    • Laurenzana, A., Fibbi, G., Margheri, F., Biagioni, A., Luciani, C., Del Rosso, M., et al. Endothelial progenitor cells in sprouting angiogenesis: proteases pave the way. Curr Mol Med 15:7 (2015), 606–620.
    • (2015) Curr Mol Med , vol.15 , Issue.7 , pp. 606-620
    • Laurenzana, A.1    Fibbi, G.2    Margheri, F.3    Biagioni, A.4    Luciani, C.5    Del Rosso, M.6
  • 20
    • 0034473682 scopus 로고    scopus 로고
    • Angiogenesis, metastasis, and endogenous inhibition
    • Kirsch, M., Schackert, G., Black, P.M., Angiogenesis, metastasis, and endogenous inhibition. J Neurooncol 50:1–2 (2000), 173–180.
    • (2000) J Neurooncol , vol.50 , Issue.1-2 , pp. 173-180
    • Kirsch, M.1    Schackert, G.2    Black, P.M.3
  • 21
    • 0022610896 scopus 로고
    • Interactions between newly formed endothelial channels and carcinoma cells in plasma clot culture
    • Nicosia, R.F., Tchao, R., Leighton, J., Interactions between newly formed endothelial channels and carcinoma cells in plasma clot culture. Clin Exp Metas 4:2 (1986), 91–104.
    • (1986) Clin Exp Metas , vol.4 , Issue.2 , pp. 91-104
    • Nicosia, R.F.1    Tchao, R.2    Leighton, J.3
  • 22
    • 84938580435 scopus 로고    scopus 로고
    • The contribution of angiogenesis to the process of metastasis
    • Bielenberg, D.R., Zetter, B.R., The contribution of angiogenesis to the process of metastasis. Cancer J 21:4 (2015), 267–273.
    • (2015) Cancer J , vol.21 , Issue.4 , pp. 267-273
    • Bielenberg, D.R.1    Zetter, B.R.2
  • 23
    • 67649525776 scopus 로고    scopus 로고
    • Angiogenesis in pre-malignant conditions
    • Raica, M., Cimpean, A.M., Ribatti, D., Angiogenesis in pre-malignant conditions. Eur J Cancer 45:11 (2009), 1924–1934.
    • (2009) Eur J Cancer , vol.45 , Issue.11 , pp. 1924-1934
    • Raica, M.1    Cimpean, A.M.2    Ribatti, D.3
  • 25
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive, K.P., Jacobetz, M.A., Davidson, C.J., Gopinathan, A., McIntyre, D., Honess, D., et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324:5933 (2009), 1457–1461.
    • (2009) Science , vol.324 , Issue.5933 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3    Gopinathan, A.4    McIntyre, D.5    Honess, D.6
  • 28
    • 77955496673 scopus 로고    scopus 로고
    • Pericytes and vessel maturation during tumor angiogenesis and metastasis
    • Raza, A., Franklin, M.J., Dudek, A.Z., Pericytes and vessel maturation during tumor angiogenesis and metastasis. Am J Hematol 85:8 (2010), 593–598.
    • (2010) Am J Hematol , vol.85 , Issue.8 , pp. 593-598
    • Raza, A.1    Franklin, M.J.2    Dudek, A.Z.3
  • 29
    • 0024801035 scopus 로고
    • Vascular permeability factor, an endothelial cell mitogen related to platelet derived growth factor
    • Kech, P., Hauser, S., Krivi, G., Sanzo, K., Warren, T., Feder, J., et al. Vascular permeability factor, an endothelial cell mitogen related to platelet derived growth factor. Science 246:4935 (1989), 1309–1312.
    • (1989) Science , vol.246 , Issue.4935 , pp. 1309-1312
    • Kech, P.1    Hauser, S.2    Krivi, G.3    Sanzo, K.4    Warren, T.5    Feder, J.6
  • 30
  • 31
    • 33644536374 scopus 로고    scopus 로고
    • Effects of the vascular disrupting agent ZD6126 on interstitial fluid pressure and cell survival in tumors
    • Skliarenko, J.V., Lunt, S.J., Gordon, M.L., Vitkin, A., Milosevic, M., Hill, R.P., Effects of the vascular disrupting agent ZD6126 on interstitial fluid pressure and cell survival in tumors. Can Res 66:4 (2006), 2074–2080.
    • (2006) Can Res , vol.66 , Issue.4 , pp. 2074-2080
    • Skliarenko, J.V.1    Lunt, S.J.2    Gordon, M.L.3    Vitkin, A.4    Milosevic, M.5    Hill, R.P.6
  • 32
    • 0037778194 scopus 로고    scopus 로고
    • Tumour dose response to the antivascular agent ZD6126 assessed by magnetic resonance imaging
    • Robinson, S.P., McIntyre, D.J., Checkley, D., Tessier, J.J., Howe, F.A., Griffiths, J.R., et al. Tumour dose response to the antivascular agent ZD6126 assessed by magnetic resonance imaging. Br J Cancer 88:10 (2003), 1592–1597.
    • (2003) Br J Cancer , vol.88 , Issue.10 , pp. 1592-1597
    • Robinson, S.P.1    McIntyre, D.J.2    Checkley, D.3    Tessier, J.J.4    Howe, F.A.5    Griffiths, J.R.6
  • 33
    • 85016925450 scopus 로고    scopus 로고
    • Tumor rim cells: from resistance to vascular targeting agents to complete tumor ablation
    • 1010428317691001
    • Seidi, K., Jahanban-Esfahlan, R., Zarghami, N., Tumor rim cells: from resistance to vascular targeting agents to complete tumor ablation. Tumour Biol, 39(3), 2017 1010428317691001.
    • (2017) Tumour Biol , vol.39 , Issue.3
    • Seidi, K.1    Jahanban-Esfahlan, R.2    Zarghami, N.3
  • 34
    • 84994414361 scopus 로고    scopus 로고
    • Exploring novel methods for modulating tumor blood vessels in cancer treatment
    • Wong, P.P., Bodrug, N., Hodivala-Dilke, K.M., Exploring novel methods for modulating tumor blood vessels in cancer treatment. Curr Biol 26:21 (2016), R1161–R1166.
    • (2016) Curr Biol , vol.26 , Issue.21 , pp. R1161-R1166
    • Wong, P.P.1    Bodrug, N.2    Hodivala-Dilke, K.M.3
  • 35
    • 84938580435 scopus 로고    scopus 로고
    • The contribution of angiogenesis to the process of metastasis
    • Bielenberg, D.R., Zetter, B.R., The contribution of angiogenesis to the process of metastasis. Cancer J 21:4 (2015), 267–273.
    • (2015) Cancer J , vol.21 , Issue.4 , pp. 267-273
    • Bielenberg, D.R.1    Zetter, B.R.2
  • 36
    • 84964556389 scopus 로고    scopus 로고
    • The role of lymphangiogenesis and angiogenesis in tumor metastasis
    • Paduch, R., The role of lymphangiogenesis and angiogenesis in tumor metastasis. Cell Oncol (Dordr) 39:5 (2016), 397–410.
    • (2016) Cell Oncol (Dordr) , vol.39 , Issue.5 , pp. 397-410
    • Paduch, R.1
  • 37
    • 80051553001 scopus 로고    scopus 로고
    • Overexpression of metastasis-associated protein 1 is significantly correlated with tumor angiogenesis and poor survival in patients with early-stage non-small cell lung cancer
    • S-h, Li., Tian, H., W-m, Yue., Li, L., W-j, Li., Z-t, Chen., et al. Overexpression of metastasis-associated protein 1 is significantly correlated with tumor angiogenesis and poor survival in patients with early-stage non-small cell lung cancer. Ann Surg Oncol 18:7 (2011), 2048–2056.
    • (2011) Ann Surg Oncol , vol.18 , Issue.7 , pp. 2048-2056
    • Li, S.-H.1    Tian, H.2    Yue, W.-M.3    Li, L.4    Li, W.-J.5    Chen, Z.-T.6
  • 38
    • 85026628526 scopus 로고    scopus 로고
    • Web. 23 Apr. 2017; 2017.
    • Antiangiogenesis – list results – Clinicaltrials.Gov. Clinicaltrials.gov. N.p., 2017. Web. 23 Apr. 2017; 2017.
    • (2017)
  • 39
    • 77955512358 scopus 로고    scopus 로고
    • Lymphangiogenesis and lymphatic metastasis in breast cancer
    • Ran, S., Volk, L., Hall, K., Flister, M.J., Lymphangiogenesis and lymphatic metastasis in breast cancer. Pathophysiology 17:4 (2010), 229–251.
    • (2010) Pathophysiology , vol.17 , Issue.4 , pp. 229-251
    • Ran, S.1    Volk, L.2    Hall, K.3    Flister, M.J.4
  • 40
    • 84962568419 scopus 로고    scopus 로고
    • Role of tumour angiogenesis in haematological malignancies
    • Medinger, M., Passweg, J., Role of tumour angiogenesis in haematological malignancies. Swiss Med Wkly, 144, 2014, w14050.
    • (2014) Swiss Med Wkly , vol.144 , pp. w14050
    • Medinger, M.1    Passweg, J.2
  • 41
    • 0021359304 scopus 로고
    • Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor
    • Shing, Y., Folkman, J., Sullivan, R., Butterfield, C., Murray, J., Klagsbrun, M., Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science 223:4642 (1984), 1296–1299.
    • (1984) Science , vol.223 , Issue.4642 , pp. 1296-1299
    • Shing, Y.1    Folkman, J.2    Sullivan, R.3    Butterfield, C.4    Murray, J.5    Klagsbrun, M.6
  • 42
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • Carmeliet, P., Jain, R.K., Molecular mechanisms and clinical applications of angiogenesis. Nature 473:7347 (2011), 298–307.
    • (2011) Nature , vol.473 , Issue.7347 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 43
    • 0026708632 scopus 로고
    • The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies
    • Kim, K.J., Li, B., Houck, K., Winer, J., Ferrara, N., The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors 7:1 (1992), 53–64.
    • (1992) Growth Factors , vol.7 , Issue.1 , pp. 53-64
    • Kim, K.J.1    Li, B.2    Houck, K.3    Winer, J.4    Ferrara, N.5
  • 44
    • 84903901969 scopus 로고    scopus 로고
    • Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions
    • Vasudev, N.S., Reynolds, A.R., Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions. Angiogenesis 17:3 (2014), 471–494.
    • (2014) Angiogenesis , vol.17 , Issue.3 , pp. 471-494
    • Vasudev, N.S.1    Reynolds, A.R.2
  • 45
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak, H.F., Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 20:21 (2002), 4368–4380.
    • (2002) J Clin Oncol , vol.20 , Issue.21 , pp. 4368-4380
    • Dvorak, H.F.1
  • 46
    • 56749174211 scopus 로고    scopus 로고
    • FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?
    • Fischer, C., Mazzone, M., Jonckx, B., Carmeliet, P., FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?. Nat Rev Cancer 8:12 (2008), 942–956.
    • (2008) Nat Rev Cancer , vol.8 , Issue.12 , pp. 942-956
    • Fischer, C.1    Mazzone, M.2    Jonckx, B.3    Carmeliet, P.4
  • 47
    • 76749083490 scopus 로고    scopus 로고
    • Lymphangiogenesis: molecular mechanisms and future promise
    • Tammela, T., Alitalo, K., Lymphangiogenesis: molecular mechanisms and future promise. Cell 140:4 (2010), 460–476.
    • (2010) Cell , vol.140 , Issue.4 , pp. 460-476
    • Tammela, T.1    Alitalo, K.2
  • 48
    • 34547941252 scopus 로고    scopus 로고
    • Autocrine VEGF signaling is required for vascular homeostasis
    • Lee, S., Chen, T.T., Barber, C.L., Jordan, M.C., Murdock, J., Desai, S., et al. Autocrine VEGF signaling is required for vascular homeostasis. Cell 130:4 (2007), 691–703.
    • (2007) Cell , vol.130 , Issue.4 , pp. 691-703
    • Lee, S.1    Chen, T.T.2    Barber, C.L.3    Jordan, M.C.4    Murdock, J.5    Desai, S.6
  • 49
    • 84941781254 scopus 로고    scopus 로고
    • Therapeutic uses of FGFs.
    • Zhang J, Li Y, editors. Therapeutic uses of FGFs. Semin Cell Dev Biol 2016;53:144–54.
    • (2016) Semin Cell Dev Biol , vol.53 , pp. 144-54
    • Zhang, J.1    Li, Y.2
  • 50
    • 84958747810 scopus 로고    scopus 로고
    • Anti-angiogenic alternatives to VEGF blockade
    • Khan, K.A., Bicknell, R., Anti-angiogenic alternatives to VEGF blockade. Clin Exp Metas 33:2 (2016), 197–210.
    • (2016) Clin Exp Metas , vol.33 , Issue.2 , pp. 197-210
    • Khan, K.A.1    Bicknell, R.2
  • 51
    • 75749096309 scopus 로고    scopus 로고
    • Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance
    • Kopetz, S., Hoff, P.M., Morris, J.S., Wolff, R.A., Eng, C., Glover, K.Y., et al. Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance. J Clin Oncol 28:3 (2010), 453–459.
    • (2010) J Clin Oncol , vol.28 , Issue.3 , pp. 453-459
    • Kopetz, S.1    Hoff, P.M.2    Morris, J.S.3    Wolff, R.A.4    Eng, C.5    Glover, K.Y.6
  • 53
    • 0034671392 scopus 로고    scopus 로고
    • Fibroblast growth factors are required for efficient tumor angiogenesis
    • Compagni, A., Wilgenbus, P., Impagnatiello, M.-A., Cotten, M., Christofori, G., Fibroblast growth factors are required for efficient tumor angiogenesis. Can Res 60:24 (2000), 7163–7169.
    • (2000) Can Res , vol.60 , Issue.24 , pp. 7163-7169
    • Compagni, A.1    Wilgenbus, P.2    Impagnatiello, M.-A.3    Cotten, M.4    Christofori, G.5
  • 54
    • 84862751803 scopus 로고    scopus 로고
    • A novel monoclonal antibody to fibroblast growth factor 2 effectively inhibits growth of hepatocellular carcinoma xenografts
    • Wang, L., Park, H., Chhim, S., Ding, Y., Jiang, W., Queen, C., et al. A novel monoclonal antibody to fibroblast growth factor 2 effectively inhibits growth of hepatocellular carcinoma xenografts. Mol Cancer Ther 11:4 (2012), 864–872.
    • (2012) Mol Cancer Ther , vol.11 , Issue.4 , pp. 864-872
    • Wang, L.1    Park, H.2    Chhim, S.3    Ding, Y.4    Jiang, W.5    Queen, C.6
  • 55
    • 0037085234 scopus 로고    scopus 로고
    • New members of the platelet-derived growth factor family of mitogens
    • Heldin, C.-H., Eriksson, U., Östman, A., New members of the platelet-derived growth factor family of mitogens. Arch Biochem Biophys 398:2 (2002), 284–290.
    • (2002) Arch Biochem Biophys , vol.398 , Issue.2 , pp. 284-290
    • Heldin, C.-H.1    Eriksson, U.2    Östman, A.3
  • 56
    • 84932616956 scopus 로고    scopus 로고
    • Targeting angiogenesis in cancer therapy: moving beyond vascular endothelial growth factor
    • Zhao, Y., Adjei, A.A., Targeting angiogenesis in cancer therapy: moving beyond vascular endothelial growth factor. Oncologist 20:6 (2015), 660–673.
    • (2015) Oncologist , vol.20 , Issue.6 , pp. 660-673
    • Zhao, Y.1    Adjei, A.A.2
  • 57
    • 84879288021 scopus 로고    scopus 로고
    • PlGF: a multitasking cytokine with disease-restricted activity
    • Dewerchin, M., Carmeliet, P., PlGF: a multitasking cytokine with disease-restricted activity. Cold Spring Harb Perspect Med, 2, 2012, a011056.
    • (2012) Cold Spring Harb Perspect Med , vol.2 , pp. a011056
    • Dewerchin, M.1    Carmeliet, P.2
  • 58
    • 84861307333 scopus 로고    scopus 로고
    • Inhibition of placenta growth factor with TB-403: a novel antiangiogenic cancer therapy
    • Nielsen, D.L., Sengeløv, L., Inhibition of placenta growth factor with TB-403: a novel antiangiogenic cancer therapy. Expert Opin Biol Ther 12:6 (2012), 795–804.
    • (2012) Expert Opin Biol Ther , vol.12 , Issue.6 , pp. 795-804
    • Nielsen, D.L.1    Sengeløv, L.2
  • 59
    • 67650753834 scopus 로고    scopus 로고
    • The role of the angiopoietins in vascular morphogenesis
    • Thomas, M., Augustin, H.G., The role of the angiopoietins in vascular morphogenesis. Angiogenesis 12:2 (2009), 125–137.
    • (2009) Angiogenesis , vol.12 , Issue.2 , pp. 125-137
    • Thomas, M.1    Augustin, H.G.2
  • 60
    • 64649084437 scopus 로고    scopus 로고
    • Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium
    • Yuan, H.T., Khankin, E.V., Karumanchi, S.A., Parikh, S.M., Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol 29:8 (2009), 2011–2022.
    • (2009) Mol Cell Biol , vol.29 , Issue.8 , pp. 2011-2022
    • Yuan, H.T.1    Khankin, E.V.2    Karumanchi, S.A.3    Parikh, S.M.4
  • 61
    • 84879761446 scopus 로고    scopus 로고
    • MET: a critical player in tumorigenesis and therapeutic target
    • Graveel, C.R., Tolbert, D., Woude, G.F.V., MET: a critical player in tumorigenesis and therapeutic target. Cold Spring Harb Perspect Biol, 5(7), 2013, a009209.
    • (2013) Cold Spring Harb Perspect Biol , vol.5 , Issue.7 , pp. a009209
    • Graveel, C.R.1    Tolbert, D.2    Woude, G.F.V.3
  • 62
    • 84877098516 scopus 로고    scopus 로고
    • Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance
    • Jahangiri, A., De Lay, M., Miller, L.M., Carbonell, W.S., Hu, Y.-L., Lu, K., et al. Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance. Clin Cancer Res 19:7 (2013), 1773–1783.
    • (2013) Clin Cancer Res , vol.19 , Issue.7 , pp. 1773-1783
    • Jahangiri, A.1    De Lay, M.2    Miller, L.M.3    Carbonell, W.S.4    Hu, Y.-L.5    Lu, K.6
  • 65
    • 82655164839 scopus 로고    scopus 로고
    • Dll4-Notch signaling as a therapeutic target in tumor angiogenesis
    • Kuhnert, F., Kirshner, J.R., Thurston, G., Dll4-Notch signaling as a therapeutic target in tumor angiogenesis. Vasc Cell, 3(1), 2011, 1.
    • (2011) Vasc Cell , vol.3 , Issue.1 , pp. 1
    • Kuhnert, F.1    Kirshner, J.R.2    Thurston, G.3
  • 66
    • 33847046849 scopus 로고    scopus 로고
    • Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
    • Hellström, M., Phng, L.-K., Hofmann, J.J., Wallgard, E., Coultas, L., Lindblom, P., et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445:7129 (2007), 776–780.
    • (2007) Nature , vol.445 , Issue.7129 , pp. 776-780
    • Hellström, M.1    Phng, L.-K.2    Hofmann, J.J.3    Wallgard, E.4    Coultas, L.5    Lindblom, P.6
  • 67
    • 25444506836 scopus 로고    scopus 로고
    • Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function
    • Patel, N.S., Li, J.-L., Generali, D., Poulsom, R., Cranston, D.W., Harris, A.L., Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Can Res 65:19 (2005), 8690–8697.
    • (2005) Can Res , vol.65 , Issue.19 , pp. 8690-8697
    • Patel, N.S.1    Li, J.-L.2    Generali, D.3    Poulsom, R.4    Cranston, D.W.5    Harris, A.L.6
  • 70
    • 77951677126 scopus 로고    scopus 로고
    • Eph receptors and ephrin ligands: important players in angiogenesis and tumor angiogenesis. J Oncol 2010;2010.
    • Mosch B, Reissenweber B, Neuber C, Pietzsch J. Eph receptors and ephrin ligands: important players in angiogenesis and tumor angiogenesis. J Oncol 2010;2010.
    • Mosch, B.1    Reissenweber, B.2    Neuber, C.3    Pietzsch, J.4
  • 71
    • 0345269144 scopus 로고    scopus 로고
    • Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis
    • Cheng, N., Brantley, D.M., Liu, H., Lin, Q., Enriquez, M., Gale, N., et al. Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis. Mol Cancer Res 1:1 (2002), 2–11.
    • (2002) Mol Cancer Res , vol.1 , Issue.1 , pp. 2-11
    • Cheng, N.1    Brantley, D.M.2    Liu, H.3    Lin, Q.4    Enriquez, M.5    Gale, N.6
  • 72
    • 77953022206 scopus 로고    scopus 로고
    • Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis
    • Sawamiphak, S., Seidel, S., Essmann, C.L., Wilkinson, G.A., Pitulescu, M.E., Acker, T., et al. Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis. Nature 465:7297 (2010), 487–491.
    • (2010) Nature , vol.465 , Issue.7297 , pp. 487-491
    • Sawamiphak, S.1    Seidel, S.2    Essmann, C.L.3    Wilkinson, G.A.4    Pitulescu, M.E.5    Acker, T.6
  • 73
    • 84868143439 scopus 로고    scopus 로고
    • alphaV integrins in angiogenesis and cancer. Cold Spring Harb Perspect Med 2011;1:a006478.
    • Weis S, Cheresh D. alphaV integrins in angiogenesis and cancer. Cold Spring Harb Perspect Med 2011;1:a006478.
    • Weis, S.1    Cheresh, D.2
  • 74
    • 0029610677 scopus 로고
    • Definition of two angiogenic pathways by distinct alphav integrins
    • Friedlander, M., Brooks, P.C., Shaffer, R.W., Kincaid, C.M., Definition of two angiogenic pathways by distinct alphav integrins. Science 270:5241 (1995), 1500–1502.
    • (1995) Science , vol.270 , Issue.5241 , pp. 1500-1502
    • Friedlander, M.1    Brooks, P.C.2    Shaffer, R.W.3    Kincaid, C.M.4
  • 75
    • 84873087237 scopus 로고    scopus 로고
    • CD146, a multi-functional molecule beyond adhesion
    • Wang, Z., Yan, X., CD146, a multi-functional molecule beyond adhesion. Cancer Lett 330:2 (2013), 150–162.
    • (2013) Cancer Lett , vol.330 , Issue.2 , pp. 150-162
    • Wang, Z.1    Yan, X.2
  • 76
    • 84901287170 scopus 로고    scopus 로고
    • Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice
    • Zeng, Q., Wu, Z., Duan, H., Jiang, X., Tu, T., Lu, D., et al. Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice. Protein Cell 5:6 (2014), 445–456.
    • (2014) Protein Cell , vol.5 , Issue.6 , pp. 445-456
    • Zeng, Q.1    Wu, Z.2    Duan, H.3    Jiang, X.4    Tu, T.5    Lu, D.6
  • 77
    • 84863713142 scopus 로고    scopus 로고
    • Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS
    • Flanagan, K., Fitzgerald, K., Baker, J., Regnstrom, K., Gardai, S., Bard, F., et al. Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS. PLoS ONE, 7(7), 2012, e40443.
    • (2012) PLoS ONE , vol.7 , Issue.7 , pp. e40443
    • Flanagan, K.1    Fitzgerald, K.2    Baker, J.3    Regnstrom, K.4    Gardai, S.5    Bard, F.6
  • 78
    • 84924521970 scopus 로고    scopus 로고
    • CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development
    • Tu, T., Zhang, C., Yan, H., Luo, Y., Kong, R., Wen, P., et al. CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. Cell Res 25:3 (2015), 275–287.
    • (2015) Cell Res , vol.25 , Issue.3 , pp. 275-287
    • Tu, T.1    Zhang, C.2    Yan, H.3    Luo, Y.4    Kong, R.5    Wen, P.6
  • 79
    • 84859854623 scopus 로고    scopus 로고
    • Vascular endothelial-cadherin and vascular stability
    • Dejana, E., Giampietro, C., Vascular endothelial-cadherin and vascular stability. Curr Opin Hematol 19:3 (2012), 218–223.
    • (2012) Curr Opin Hematol , vol.19 , Issue.3 , pp. 218-223
    • Dejana, E.1    Giampietro, C.2
  • 80
    • 18344364910 scopus 로고    scopus 로고
    • The human VE-cadherin promoter is subjected to organ-specific regulation and is activated in tumour angiogenesis
    • Prandini, M.-H., Dreher, I., Bouillot, S., Benkerri, S., Moll, T., Huber, P., The human VE-cadherin promoter is subjected to organ-specific regulation and is activated in tumour angiogenesis. Oncogene 24:18 (2005), 2992–3001.
    • (2005) Oncogene , vol.24 , Issue.18 , pp. 2992-3001
    • Prandini, M.-H.1    Dreher, I.2    Bouillot, S.3    Benkerri, S.4    Moll, T.5    Huber, P.6
  • 81
    • 77956886193 scopus 로고    scopus 로고
    • The soluble fragment of VE-cadherin inhibits angiogenesis by reducing endothelial cell proliferation and tube capillary formation
    • Li, H., Shi, X., Liu, J., Hu, C., Zhang, X., Liu, H., et al. The soluble fragment of VE-cadherin inhibits angiogenesis by reducing endothelial cell proliferation and tube capillary formation. Cancer Gene Ther 17:10 (2010), 700–707.
    • (2010) Cancer Gene Ther , vol.17 , Issue.10 , pp. 700-707
    • Li, H.1    Shi, X.2    Liu, J.3    Hu, C.4    Zhang, X.5    Liu, H.6
  • 82
    • 84863012047 scopus 로고    scopus 로고
    • TEM8/ANTXR1 blockade inhibits pathological angiogenesis and potentiates tumoricidal responses against multiple cancer types
    • Chaudhary, A., Hilton, M.B., Seaman, S., Haines, D.C., Stevenson, S., Lemotte, P.K., et al. TEM8/ANTXR1 blockade inhibits pathological angiogenesis and potentiates tumoricidal responses against multiple cancer types. Cancer Cell 21:2 (2012), 212–226.
    • (2012) Cancer Cell , vol.21 , Issue.2 , pp. 212-226
    • Chaudhary, A.1    Hilton, M.B.2    Seaman, S.3    Haines, D.C.4    Stevenson, S.5    Lemotte, P.K.6
  • 84
    • 84871655253 scopus 로고    scopus 로고
    • Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies
    • Nolan-Stevaux, O., Zhong, W., Culp, S., Shaffer, K., Hoover, J., Wickramasinghe, D., et al. Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies. PLoS ONE, 7(12), 2012, e50920.
    • (2012) PLoS ONE , vol.7 , Issue.12 , pp. e50920
    • Nolan-Stevaux, O.1    Zhong, W.2    Culp, S.3    Shaffer, K.4    Hoover, J.5    Wickramasinghe, D.6
  • 85
    • 84944400960 scopus 로고    scopus 로고
    • Angiopoietin-like protein 2 induces proinflammatory responses in peritoneal cells
    • Umikawa, M., Umikawa, A., Asato, T., Takei, K., Matsuzaki, G., K-i, Kariya., et al. Angiopoietin-like protein 2 induces proinflammatory responses in peritoneal cells. Biochem Biophys Res Commun 467:2 (2015), 235–241.
    • (2015) Biochem Biophys Res Commun , vol.467 , Issue.2 , pp. 235-241
    • Umikawa, M.1    Umikawa, A.2    Asato, T.3    Takei, K.4    Matsuzaki, G.5    Kariya, K.6
  • 86
    • 72549108629 scopus 로고    scopus 로고
    • Role of class 3 semaphorins and their receptors in tumor growth and angiogenesis
    • Gaur, P., Bielenberg, D.R., Samuel, S., Bose, D., Zhou, Y., Gray, M.J., et al. Role of class 3 semaphorins and their receptors in tumor growth and angiogenesis. Clin Cancer Res 15:22 (2009), 6763–6770.
    • (2009) Clin Cancer Res , vol.15 , Issue.22 , pp. 6763-6770
    • Gaur, P.1    Bielenberg, D.R.2    Samuel, S.3    Bose, D.4    Zhou, Y.5    Gray, M.J.6
  • 88
    • 84865151606 scopus 로고    scopus 로고
    • Semaphorin 4D cooperates with VEGF to promote angiogenesis and tumor progression
    • Zhou, H., Binmadi, N.O., Yang, Y.-H., Proia, P., Basile, J.R., Semaphorin 4D cooperates with VEGF to promote angiogenesis and tumor progression. Angiogenesis 15:3 (2012), 391–407.
    • (2012) Angiogenesis , vol.15 , Issue.3 , pp. 391-407
    • Zhou, H.1    Binmadi, N.O.2    Yang, Y.-H.3    Proia, P.4    Basile, J.R.5
  • 89
    • 81855212544 scopus 로고    scopus 로고
    • The role of RhoJ in endothelial cell biology and angiogenesis
    • Dec
    • Leszczynska, K., Kaur, S., Wilson, E., Bicknell, R., Heath, V.L., The role of RhoJ in endothelial cell biology and angiogenesis. Biochem Soc Trans 39:6 (2011 Dec), 1606–1611.
    • (2011) Biochem Soc Trans , vol.39 , Issue.6 , pp. 1606-1611
    • Leszczynska, K.1    Kaur, S.2    Wilson, E.3    Bicknell, R.4    Heath, V.L.5
  • 90
    • 84855915831 scopus 로고    scopus 로고
    • Identification and angiogenic role of the novel tumor endothelial marker CLEC14A
    • Mura, M., Swain, R., Zhuang, X., Vorschmitt, H., Reynolds, G., Durant, S., et al. Identification and angiogenic role of the novel tumor endothelial marker CLEC14A. Oncogene 31:3 (2012), 293–305.
    • (2012) Oncogene , vol.31 , Issue.3 , pp. 293-305
    • Mura, M.1    Swain, R.2    Zhuang, X.3    Vorschmitt, H.4    Reynolds, G.5    Durant, S.6
  • 91
    • 84947870788 scopus 로고    scopus 로고
    • Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth
    • Noy, P., Lodhia, P., Khan, K., Zhuang, X., Ward, D., Verissimo, A., et al. Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth. Oncogene, 2015.
    • (2015) Oncogene
    • Noy, P.1    Lodhia, P.2    Khan, K.3    Zhuang, X.4    Ward, D.5    Verissimo, A.6
  • 93
    • 84875510382 scopus 로고    scopus 로고
    • Domains I and IV of annexin A2 affect the formation and integrity of in vitro capillary-like networks
    • Raddum, A.M., Evensen, L., Hollås, H., Grindheim, A.K., Lorens, J.B., Vedeler, A., Domains I and IV of annexin A2 affect the formation and integrity of in vitro capillary-like networks. PLoS ONE, 8(3), 2013, e60281.
    • (2013) PLoS ONE , vol.8 , Issue.3 , pp. e60281
    • Raddum, A.M.1    Evensen, L.2    Hollås, H.3    Grindheim, A.K.4    Lorens, J.B.5    Vedeler, A.6
  • 94
    • 84930911897 scopus 로고    scopus 로고
    • The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects
    • Raddum, A.M., Hollås, H., Shumilin, I.A., Henklein, P., Kretsinger, R., Fossen, T., et al. The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects. Biochem Pharmacol 95:1 (2015), 1–15.
    • (2015) Biochem Pharmacol , vol.95 , Issue.1 , pp. 1-15
    • Raddum, A.M.1    Hollås, H.2    Shumilin, I.A.3    Henklein, P.4    Kretsinger, R.5    Fossen, T.6
  • 95
    • 84961213727 scopus 로고    scopus 로고
    • Adhesion molecules and the extracellular matrix as drug targets for glioma
    • Shimizu, T., Kurozumi, K., Ishida, J., Ichikawa, T., Date, I., Adhesion molecules and the extracellular matrix as drug targets for glioma. Brain Tumor Pathol 33:2 (2016), 97–106.
    • (2016) Brain Tumor Pathol , vol.33 , Issue.2 , pp. 97-106
    • Shimizu, T.1    Kurozumi, K.2    Ishida, J.3    Ichikawa, T.4    Date, I.5
  • 96
    • 85014072446 scopus 로고    scopus 로고
    • Effectiveness of antiangiogenic drugs in glioblastoma patients: a systematic review and meta-analysis of randomized clinical trials
    • Lombardi, G., Pambuku, A., Bellu, L., Farina, M., Della Puppa, A., Denaro, L., et al. Effectiveness of antiangiogenic drugs in glioblastoma patients: a systematic review and meta-analysis of randomized clinical trials. Crit Rev Oncol Hematol 111 (2017), 94–102.
    • (2017) Crit Rev Oncol Hematol , vol.111 , pp. 94-102
    • Lombardi, G.1    Pambuku, A.2    Bellu, L.3    Farina, M.4    Della Puppa, A.5    Denaro, L.6
  • 98
    • 85000500151 scopus 로고    scopus 로고
    • Angiogenesis inhibitors as therapeutic agents in cancer: challenges and future directions
    • Lin, Z., Zhang, Q., Luo, W., Angiogenesis inhibitors as therapeutic agents in cancer: challenges and future directions. Eur J Pharmacol, 2016.
    • (2016) Eur J Pharmacol
    • Lin, Z.1    Zhang, Q.2    Luo, W.3
  • 99
    • 84976345090 scopus 로고    scopus 로고
    • Ramucirumab: a vascular endothelial growth factor receptor-2 inhibitor with activity in several malignancies
    • Grabowski, J., Glode, A., Ramucirumab: a vascular endothelial growth factor receptor-2 inhibitor with activity in several malignancies. Am J Health Syst Pharm 73:13 (2016), 957–968.
    • (2016) Am J Health Syst Pharm , vol.73 , Issue.13 , pp. 957-968
    • Grabowski, J.1    Glode, A.2
  • 100
    • 84890667775 scopus 로고    scopus 로고
    • Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy
    • Kienast, Y., Klein, C., Scheuer, W., Raemsch, R., Lorenzon, E., Bernicke, D., et al. Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy. Clin Cancer Res 19:24 (2013), 6730–6740.
    • (2013) Clin Cancer Res , vol.19 , Issue.24 , pp. 6730-6740
    • Kienast, Y.1    Klein, C.2    Scheuer, W.3    Raemsch, R.4    Lorenzon, E.5    Bernicke, D.6
  • 101
    • 84983128441 scopus 로고    scopus 로고
    • Aflibercept a new target therapy in cancer treatment: a review
    • Ricci, V., Ronzoni, M., Fabozzi, T., Aflibercept a new target therapy in cancer treatment: a review. Crit Rev Oncol Hematol 96:3 (2015), 569–576.
    • (2015) Crit Rev Oncol Hematol , vol.96 , Issue.3 , pp. 569-576
    • Ricci, V.1    Ronzoni, M.2    Fabozzi, T.3
  • 102
    • 84978082136 scopus 로고    scopus 로고
    • Aflibercept, a new way to target angiogenesis in the second line treatment of metastatic colorectal cancer (mCRC)
    • Scartozzi, M., Vincent, L., Chiron, M., Cascinu, S., Aflibercept, a new way to target angiogenesis in the second line treatment of metastatic colorectal cancer (mCRC). Target Oncol 11:4 (2016), 489–500.
    • (2016) Target Oncol , vol.11 , Issue.4 , pp. 489-500
    • Scartozzi, M.1    Vincent, L.2    Chiron, M.3    Cascinu, S.4
  • 103
    • 84908222420 scopus 로고    scopus 로고
    • Profile of trebananib (AMG386) and its potential in the treatment of ovarian cancer
    • Liontos, M., Lykka, M., Bamias, A., Profile of trebananib (AMG386) and its potential in the treatment of ovarian cancer. Onco Targets Ther 7 (2014), 1837–1845.
    • (2014) Onco Targets Ther , vol.7 , pp. 1837-1845
    • Liontos, M.1    Lykka, M.2    Bamias, A.3
  • 105
    • 84961392655 scopus 로고    scopus 로고
    • Efficacy of trebananib (AMG 386) in treating epithelial ovarian cancer
    • Al Wadi, K., Ghatage, P., Efficacy of trebananib (AMG 386) in treating epithelial ovarian cancer. Expert Opin Pharmacother 17:6 (2016), 853–860.
    • (2016) Expert Opin Pharmacother , vol.17 , Issue.6 , pp. 853-860
    • Al Wadi, K.1    Ghatage, P.2
  • 106
    • 84904098885 scopus 로고    scopus 로고
    • A novel decoy receptor fusion protein for FGF-2 potently inhibits tumour growth
    • Li, D., Wei, X., Xie, K., Chen, K., Li, J., Fang, J., A novel decoy receptor fusion protein for FGF-2 potently inhibits tumour growth. Br J Cancer 111:1 (2014), 68–77.
    • (2014) Br J Cancer , vol.111 , Issue.1 , pp. 68-77
    • Li, D.1    Wei, X.2    Xie, K.3    Chen, K.4    Li, J.5    Fang, J.6
  • 107
    • 33845877157 scopus 로고    scopus 로고
    • Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    • Noguera-Troise, I., Daly, C., Papadopoulos, N.J., Coetzee, S., Boland, P., Gale, N.W., et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444:7122 (2006), 1032–1037.
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1032-1037
    • Noguera-Troise, I.1    Daly, C.2    Papadopoulos, N.J.3    Coetzee, S.4    Boland, P.5    Gale, N.W.6
  • 108
    • 18644379904 scopus 로고    scopus 로고
    • Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo
    • Brantley, D.M., Cheng, N., Thompson, E.J., Lin, Q., Brekken, R.A., Thorpe, P.E., et al. Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene 21:46 (2002), 7011–7026.
    • (2002) Oncogene , vol.21 , Issue.46 , pp. 7011-7026
    • Brantley, D.M.1    Cheng, N.2    Thompson, E.J.3    Lin, Q.4    Brekken, R.A.5    Thorpe, P.E.6
  • 110
    • 84865556743 scopus 로고    scopus 로고
    • A phase II trial (AGO 2.11) in platinum-resistant ovarian cancer: a randomized multicenter trial with sunitinib (SU11248) to evaluate dosage, schedule, tolerability, toxicity and effectiveness of a multitargeted receptor tyrosine kinase inhibitor monotherapy
    • Baumann, K., Du Bois, A., Meier, W., Rau, J., Wimberger, P., Sehouli, J., et al. A phase II trial (AGO 2.11) in platinum-resistant ovarian cancer: a randomized multicenter trial with sunitinib (SU11248) to evaluate dosage, schedule, tolerability, toxicity and effectiveness of a multitargeted receptor tyrosine kinase inhibitor monotherapy. Ann Oncol 23:9 (2012), 2265–2271.
    • (2012) Ann Oncol , vol.23 , Issue.9 , pp. 2265-2271
    • Baumann, K.1    Du Bois, A.2    Meier, W.3    Rau, J.4    Wimberger, P.5    Sehouli, J.6
  • 112
    • 84951906637 scopus 로고    scopus 로고
    • Benefit, risk, and outcomes in drug development: a systematic review of sunitinib. J Natl Cancer Inst 2016;108(1):djv292.
    • Carlisle B, Demko N, Freeman G, Hakala A, MacKinnon N, Ramsay T, et al. Benefit, risk, and outcomes in drug development: a systematic review of sunitinib. J Natl Cancer Inst 2016;108(1):djv292.
    • Carlisle, B.1    Demko, N.2    Freeman, G.3    Hakala, A.4    MacKinnon, N.5    Ramsay, T.6
  • 113
    • 84890274647 scopus 로고    scopus 로고
    • Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL study
    • Johnson, P.J., Qin, S., Park, J.-W., Poon, R.T., Raoul, J.-L., Philip, P.A., et al. Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL study. J Clin Oncol 31:28 (2013), 3517–3524.
    • (2013) J Clin Oncol , vol.31 , Issue.28 , pp. 3517-3524
    • Johnson, P.J.1    Qin, S.2    Park, J.-W.3    Poon, R.T.4    Raoul, J.-L.5    Philip, P.A.6
  • 114
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge, S.R., Kendrew, J., Hennequin, L.F., Valentine, P.J., Barry, S.T., Brave, S.R., et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Can Res 65:10 (2005), 4389–4400.
    • (2005) Can Res , vol.65 , Issue.10 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3    Valentine, P.J.4    Barry, S.T.5    Brave, S.R.6
  • 115
    • 84874851836 scopus 로고    scopus 로고
    • Phase I study of dovitinib (TKI258), an oral FGFR, VEGFR, and PDGFR inhibitor, in advanced or metastatic renal cell carcinoma
    • Angevin, E., Lopez-Martin, J.A., Lin, C.-C., Gschwend, J.E., Harzstark, A., Castellano, D., et al. Phase I study of dovitinib (TKI258), an oral FGFR, VEGFR, and PDGFR inhibitor, in advanced or metastatic renal cell carcinoma. Clin Cancer Res 19:5 (2013), 1257–1268.
    • (2013) Clin Cancer Res , vol.19 , Issue.5 , pp. 1257-1268
    • Angevin, E.1    Lopez-Martin, J.A.2    Lin, C.-C.3    Gschwend, J.E.4    Harzstark, A.5    Castellano, D.6
  • 116
    • 53049085556 scopus 로고    scopus 로고
    • Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase
    • Matsui, J., Funahashi, Y., Uenaka, T., Watanabe, T., Tsuruoka, A., Asada, M., Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase. Clin Cancer Res 14:17 (2008), 5459–5465.
    • (2008) Clin Cancer Res , vol.14 , Issue.17 , pp. 5459-5465
    • Matsui, J.1    Funahashi, Y.2    Uenaka, T.3    Watanabe, T.4    Tsuruoka, A.5    Asada, M.6
  • 117
    • 84920993186 scopus 로고    scopus 로고
    • Linifanib versus Sorafenib in patients with advanced hepatocellular carcinoma: results of a randomized phase III trial
    • Cainap, C., Qin, S., Huang, W.-T., Chung, I.J., Pan, H., Cheng, Y., et al. Linifanib versus Sorafenib in patients with advanced hepatocellular carcinoma: results of a randomized phase III trial. J Clin Oncol 33:2 (2015), 172–179.
    • (2015) J Clin Oncol , vol.33 , Issue.2 , pp. 172-179
    • Cainap, C.1    Qin, S.2    Huang, W.-T.3    Chung, I.J.4    Pan, H.5    Cheng, Y.6
  • 118
    • 69249142285 scopus 로고    scopus 로고
    • ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside
    • Zhou, J., Goh, B.C., Albert, D.H., Chen, C.S., ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside. J Hematol Oncol, 2, 2009, 33.
    • (2009) J Hematol Oncol , vol.2 , pp. 33
    • Zhou, J.1    Goh, B.C.2    Albert, D.H.3    Chen, C.S.4
  • 119
    • 84858990965 scopus 로고    scopus 로고
    • Thalidomide: an old drug with new action
    • Kumar, V., Chhibber, S., Thalidomide: an old drug with new action. J Chemother 23:6 (2011), 326–334.
    • (2011) J Chemother , vol.23 , Issue.6 , pp. 326-334
    • Kumar, V.1    Chhibber, S.2
  • 120
    • 84946073292 scopus 로고    scopus 로고
    • Therapeutic potential of thalidomide and its analogues in the treatment of cancer
    • Sherbet, G.V., Therapeutic potential of thalidomide and its analogues in the treatment of cancer. Anticancer Res 35:11 (2015), 5767–5772.
    • (2015) Anticancer Res , vol.35 , Issue.11 , pp. 5767-5772
    • Sherbet, G.V.1
  • 122
    • 23044490704 scopus 로고    scopus 로고
    • Plants as a source of anti-cancer agents
    • Cragg, G.M., Newman, D.J., Plants as a source of anti-cancer agents. J Ethnopharmacol 100:1–2 (2005), 72–79.
    • (2005) J Ethnopharmacol , vol.100 , Issue.1-2 , pp. 72-79
    • Cragg, G.M.1    Newman, D.J.2
  • 123
    • 0042887593 scopus 로고    scopus 로고
    • Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphate
    • Anderson, H.L., Yap, J.T., Miller, M.P., Robbins, A., Jones, T., Price, P.M., Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphate. J Clin Oncol 21:15 (2003), 2823–2830.
    • (2003) J Clin Oncol , vol.21 , Issue.15 , pp. 2823-2830
    • Anderson, H.L.1    Yap, J.T.2    Miller, M.P.3    Robbins, A.4    Jones, T.5    Price, P.M.6
  • 124
    • 84988688657 scopus 로고    scopus 로고
    • Combretastatins: in vitro structure-activity relationship, mode of action and current clinical status
    • Jaroch, K., Karolak, M., Gorski, P., Jaroch, A., Krajewski, A., Ilnicka, A., et al. Combretastatins: in vitro structure-activity relationship, mode of action and current clinical status. Pharmacol Rep 68:6 (2016), 1266–1275.
    • (2016) Pharmacol Rep , vol.68 , Issue.6 , pp. 1266-1275
    • Jaroch, K.1    Karolak, M.2    Gorski, P.3    Jaroch, A.4    Krajewski, A.5    Ilnicka, A.6
  • 125
    • 79953648492 scopus 로고    scopus 로고
    • Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer
    • Zweifel, M., Jayson, G.C., Reed, N., Osborne, R., Hassan, B., Ledermann, J., et al. Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer. Ann Oncol 22:9 (2011), 2036–2041.
    • (2011) Ann Oncol , vol.22 , Issue.9 , pp. 2036-2041
    • Zweifel, M.1    Jayson, G.C.2    Reed, N.3    Osborne, R.4    Hassan, B.5    Ledermann, J.6
  • 126
    • 84879811416 scopus 로고    scopus 로고
    • Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin a-4 phosphate
    • Ibrahim, M.A., Do, D.V., Sepah, Y.J., Shah, S.M., Van Anden, E., Hafiz, G., et al. Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin a-4 phosphate. BMC Pharmacol Toxicol, 14, 2013, 7.
    • (2013) BMC Pharmacol Toxicol , vol.14 , pp. 7
    • Ibrahim, M.A.1    Do, D.V.2    Sepah, Y.J.3    Shah, S.M.4    Van Anden, E.5    Hafiz, G.6
  • 127
    • 84896401933 scopus 로고    scopus 로고
    • A phase I clinical trial assessing the safety and tolerability of combretastatin A4 phosphate injections
    • Liu, P., Qin, Y., Wu, L., Yang, S., Li, N., Wang, H., et al. A phase I clinical trial assessing the safety and tolerability of combretastatin A4 phosphate injections. Anticancer Drugs 25:4 (2014), 462–471.
    • (2014) Anticancer Drugs , vol.25 , Issue.4 , pp. 462-471
    • Liu, P.1    Qin, Y.2    Wu, L.3    Yang, S.4    Li, N.5    Wang, H.6
  • 128
    • 85047686294 scopus 로고    scopus 로고
    • Recent cancer drug development with xanthone structures
    • Na, Y., Recent cancer drug development with xanthone structures. J Pharm Pharmacol 61:6 (2009), 707–712.
    • (2009) J Pharm Pharmacol , vol.61 , Issue.6 , pp. 707-712
    • Na, Y.1
  • 129
    • 80051612685 scopus 로고    scopus 로고
    • Clinical development of vascular disrupting agents: what lessons can we learn from ASA404?
    • LoRusso, P.M., Boerner, S.A., Hunsberger, S., Clinical development of vascular disrupting agents: what lessons can we learn from ASA404?. J Clin Oncol 29:22 (2011), 2952–2955.
    • (2011) J Clin Oncol , vol.29 , Issue.22 , pp. 2952-2955
    • LoRusso, P.M.1    Boerner, S.A.2    Hunsberger, S.3
  • 130
    • 33750075041 scopus 로고    scopus 로고
    • Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development
    • Kruczynski, A., Poli, M., Dossi, R., Chazottes, E., Berrichon, G., Ricome, C., et al. Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development. Eur J Cancer 42:16 (2006), 2821–2832.
    • (2006) Eur J Cancer , vol.42 , Issue.16 , pp. 2821-2832
    • Kruczynski, A.1    Poli, M.2    Dossi, R.3    Chazottes, E.4    Berrichon, G.5    Ricome, C.6
  • 131
    • 84994059918 scopus 로고    scopus 로고
    • Current advances of tubulin inhibitors in nanoparticle drug delivery and vascular disruption/angiogenesis.
    • Banerjee S, Hwang DJ, Li W, Miller DD. Current advances of tubulin inhibitors in nanoparticle drug delivery and vascular disruption/angiogenesis. Molecules 2016;21(11).
    • (2016) Molecules , vol.21 , Issue.11
    • Banerjee, S.1    Hwang, D.J.2    Li, W.3    Miller, D.D.4
  • 132
    • 0015211527 scopus 로고
    • Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia
    • Wani, M.C., Taylor, H.L., Wall, M.E., Coggon, P., McPhail, A.T., Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 93:9 (1971), 2325–2327.
    • (1971) J Am Chem Soc , vol.93 , Issue.9 , pp. 2325-2327
    • Wani, M.C.1    Taylor, H.L.2    Wall, M.E.3    Coggon, P.4    McPhail, A.T.5
  • 133
    • 84920887162 scopus 로고    scopus 로고
    • Anti-angiogenic therapy versus dose-dense paclitaxel therapy for frontline treatment of epithelial ovarian cancer: review of phase III randomized clinical trials
    • Slaughter, K.N., Moore, K.N., Mannel, R.S., Anti-angiogenic therapy versus dose-dense paclitaxel therapy for frontline treatment of epithelial ovarian cancer: review of phase III randomized clinical trials. Curr Oncol Rep, 16(11), 2014, 412.
    • (2014) Curr Oncol Rep , vol.16 , Issue.11 , pp. 412
    • Slaughter, K.N.1    Moore, K.N.2    Mannel, R.S.3
  • 134
    • 84986278362 scopus 로고    scopus 로고
    • Role of angiogenic factors of herbal origin in regulation of molecular pathways that control tumor angiogenesis
    • Kumar, M., Dhatwalia, S.K., Dhawan, D.K., Role of angiogenic factors of herbal origin in regulation of molecular pathways that control tumor angiogenesis. Tumour Biol 37:11 (2016), 14341–14354.
    • (2016) Tumour Biol , vol.37 , Issue.11 , pp. 14341-14354
    • Kumar, M.1    Dhatwalia, S.K.2    Dhawan, D.K.3
  • 135
    • 51349137454 scopus 로고    scopus 로고
    • Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins
    • Kunnumakkara, A.B., Anand, P., Aggarwal, B.B., Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett 269:2 (2008), 199–225.
    • (2008) Cancer Lett , vol.269 , Issue.2 , pp. 199-225
    • Kunnumakkara, A.B.1    Anand, P.2    Aggarwal, B.B.3
  • 136
    • 84937020208 scopus 로고    scopus 로고
    • The chemomodulatory effects of resveratrol and didox on herceptin cytotoxicity in breast cancer cell lines
    • Abdel-Latif, G.A., Al-Abd, A.M., Tadros, M.G., Al-Abbasi, F.A., Khalifa, A.E., Abdel-Naim, A.B., The chemomodulatory effects of resveratrol and didox on herceptin cytotoxicity in breast cancer cell lines. Sci Rep, 5, 2015, 12054.
    • (2015) Sci Rep , vol.5 , pp. 12054
    • Abdel-Latif, G.A.1    Al-Abd, A.M.2    Tadros, M.G.3    Al-Abbasi, F.A.4    Khalifa, A.E.5    Abdel-Naim, A.B.6
  • 137
    • 84995376528 scopus 로고    scopus 로고
    • Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P-glycoprotein activity
    • Khaleel, S.A., Al-Abd, A.M., Ali, A.A., Abdel-Naim, A.B., Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P-glycoprotein activity. Sci Rep, 6, 2016, 36855.
    • (2016) Sci Rep , vol.6 , pp. 36855
    • Khaleel, S.A.1    Al-Abd, A.M.2    Ali, A.A.3    Abdel-Naim, A.B.4
  • 138
    • 84872674746 scopus 로고    scopus 로고
    • Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary
    • López-Jiménez, A., García-Caballero, M., Medina, M.Á., Quesada, A.R., Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary. Eur J Nutr 52:1 (2013), 85–95.
    • (2013) Eur J Nutr , vol.52 , Issue.1 , pp. 85-95
    • López-Jiménez, A.1    García-Caballero, M.2    Medina, M.Á.3    Quesada, A.R.4
  • 139
    • 0035964450 scopus 로고    scopus 로고
    • Resveratrol and quercetin inhibit angiogenesis in vitro
    • Igura, K., Ohta, T., Kuroda, Y., Kaji, K., Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett 171:1 (2001), 11–16.
    • (2001) Cancer Lett , vol.171 , Issue.1 , pp. 11-16
    • Igura, K.1    Ohta, T.2    Kuroda, Y.3    Kaji, K.4
  • 140
    • 84867651619 scopus 로고    scopus 로고
    • Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR-2 regulated AKT/mTOR/P70S6K signaling pathways
    • Pratheeshkumar, P., Budhraja, A., Son, Y.-O., Wang, X., Zhang, Z., Ding, S., et al. Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR-2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS ONE, 7(10), 2012, e47516.
    • (2012) PLoS ONE , vol.7 , Issue.10 , pp. e47516
    • Pratheeshkumar, P.1    Budhraja, A.2    Son, Y.-O.3    Wang, X.4    Zhang, Z.5    Ding, S.6
  • 141
    • 13844280432 scopus 로고    scopus 로고
    • The novel targets for anti-angiogenesis of genistein on human cancer cells
    • Su, S.J., Yeh, T.M., Chuang, W.J., Ho, C.L., Chang, K.L., Cheng, H.L., et al. The novel targets for anti-angiogenesis of genistein on human cancer cells. Biochem Pharmacol 69:2 (2005), 307–318.
    • (2005) Biochem Pharmacol , vol.69 , Issue.2 , pp. 307-318
    • Su, S.J.1    Yeh, T.M.2    Chuang, W.J.3    Ho, C.L.4    Chang, K.L.5    Cheng, H.L.6
  • 142
    • 84949757774 scopus 로고    scopus 로고
    • Cancer therapy with phytochemicals: evidence from clinical studies
    • Hosseini, A., Ghorbani, A., Cancer therapy with phytochemicals: evidence from clinical studies. Avicenna J Phytomed 5:2 (2015), 84–97.
    • (2015) Avicenna J Phytomed , vol.5 , Issue.2 , pp. 84-97
    • Hosseini, A.1    Ghorbani, A.2
  • 143
    • 84961345478 scopus 로고    scopus 로고
    • Aeroplysinin-1, a sponge-derived multi-targeted bioactive marine drug
    • Garcia-Vilas, J.A., Martinez-Poveda, B., Quesada, A.R., Medina, M.A., Aeroplysinin-1, a sponge-derived multi-targeted bioactive marine drug. Mar Drugs, 14(1), 2015, 1.
    • (2015) Mar Drugs , vol.14 , Issue.1 , pp. 1
    • Garcia-Vilas, J.A.1    Martinez-Poveda, B.2    Quesada, A.R.3    Medina, M.A.4
  • 144
    • 79959958353 scopus 로고    scopus 로고
    • Inhibition of tumor angiogenesis by antibodies, synthetic small molecules and natural products
    • Wahl, O., Oswald, M., Tretzel, L., Herres, E., Arend, J., Efferth, T., Inhibition of tumor angiogenesis by antibodies, synthetic small molecules and natural products. Curr Med Chem 18:21 (2011), 3136–3155.
    • (2011) Curr Med Chem , vol.18 , Issue.21 , pp. 3136-3155
    • Wahl, O.1    Oswald, M.2    Tretzel, L.3    Herres, E.4    Arend, J.5    Efferth, T.6
  • 145
    • 84937554092 scopus 로고    scopus 로고
    • Sponge derived bromotyrosines: structural diversity through natural combinatorial chemistry
    • Niemann, H., Marmann, A., Lin, W., Proksch, P., Sponge derived bromotyrosines: structural diversity through natural combinatorial chemistry. Nat Prod Commun 10:1 (2015), 219–231.
    • (2015) Nat Prod Commun , vol.10 , Issue.1 , pp. 219-231
    • Niemann, H.1    Marmann, A.2    Lin, W.3    Proksch, P.4
  • 146
    • 84945931147 scopus 로고    scopus 로고
    • Cancer anti-angiogenesis vaccines: is the tumor vasculature antigenically unique?
    • Wagner, S.C., Ichim, T.E., Ma, H., Szymanski, J., Perez, J.A., Lopez, J., et al. Cancer anti-angiogenesis vaccines: is the tumor vasculature antigenically unique?. J Transl Med, 13, 2015, 340.
    • (2015) J Transl Med , vol.13 , pp. 340
    • Wagner, S.C.1    Ichim, T.E.2    Ma, H.3    Szymanski, J.4    Perez, J.A.5    Lopez, J.6
  • 147
    • 0038718703 scopus 로고    scopus 로고
    • Altered angiogenesis and survival in human tumor-derived endothelial cells
    • Bussolati, B., Deambrosis, I., Russo, S., Deregibus, M.C., Camussi, G., Altered angiogenesis and survival in human tumor-derived endothelial cells. FASEB J 17:9 (2003), 1159–1161.
    • (2003) FASEB J , vol.17 , Issue.9 , pp. 1159-1161
    • Bussolati, B.1    Deambrosis, I.2    Russo, S.3    Deregibus, M.C.4    Camussi, G.5
  • 148
    • 33744470405 scopus 로고    scopus 로고
    • Isolation and characterization of human breast tumor-derived endothelial cells
    • Grange, C., Bussolati, B., Bruno, S., Fonsato, V., Sapino, A., Camussi, G., Isolation and characterization of human breast tumor-derived endothelial cells. Oncol Rep 15:2 (2006), 381–386.
    • (2006) Oncol Rep , vol.15 , Issue.2 , pp. 381-386
    • Grange, C.1    Bussolati, B.2    Bruno, S.3    Fonsato, V.4    Sapino, A.5    Camussi, G.6
  • 149
    • 68049139572 scopus 로고    scopus 로고
    • Human hepatocellular carcinoma tumor–derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells
    • Xiong, Y.Q., Sun, H.C., Zhang, W., Zhu, X.D., Zhuang, P.Y., Zhang, J.B., et al. Human hepatocellular carcinoma tumor–derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells. Clin Cancer Res 15:15 (2009), 4838–4846.
    • (2009) Clin Cancer Res , vol.15 , Issue.15 , pp. 4838-4846
    • Xiong, Y.Q.1    Sun, H.C.2    Zhang, W.3    Zhu, X.D.4    Zhuang, P.Y.5    Zhang, J.B.6
  • 150
    • 0346146999 scopus 로고    scopus 로고
    • Vaccination against angiogenesis-associated antigens: a novel cancer immunotherapy strategy
    • Li, Y., Bohlen, P., Hicklin, D.J., Vaccination against angiogenesis-associated antigens: a novel cancer immunotherapy strategy. Curr Mol Med 3:8 (2003), 773–779.
    • (2003) Curr Mol Med , vol.3 , Issue.8 , pp. 773-779
    • Li, Y.1    Bohlen, P.2    Hicklin, D.J.3
  • 151
    • 84897107462 scopus 로고    scopus 로고
    • Specific active immunotherapy with a VEGF vaccine in patients with advanced solid tumors. Results of the CENTAURO antigen dose escalation phase I clinical trial
    • Gavilondo, J., Hernández-Bernal, F., Ayala-Ávila, M., de la Torre, A., de la Torre, J., Morera-Díaz, Y., et al. Specific active immunotherapy with a VEGF vaccine in patients with advanced solid tumors. Results of the CENTAURO antigen dose escalation phase I clinical trial. Vaccine 32:19 (2014), 2241–2250.
    • (2014) Vaccine , vol.32 , Issue.19 , pp. 2241-2250
    • Gavilondo, J.1    Hernández-Bernal, F.2    Ayala-Ávila, M.3    de la Torre, A.4    de la Torre, J.5    Morera-Díaz, Y.6
  • 152
    • 84927155314 scopus 로고    scopus 로고
    • Anti-metastatic effects of DNA vaccine encoding single-chain trimer composed of MHC I and vascular endothelial growth factor receptor 2 peptide
    • Chen, R., Wang, S., Yao, Y., Zhou, Y., Zhang, C., Fang, J., et al. Anti-metastatic effects of DNA vaccine encoding single-chain trimer composed of MHC I and vascular endothelial growth factor receptor 2 peptide. Oncol Rep 33:5 (2015), 2269–2276.
    • (2015) Oncol Rep , vol.33 , Issue.5 , pp. 2269-2276
    • Chen, R.1    Wang, S.2    Yao, Y.3    Zhou, Y.4    Zhang, C.5    Fang, J.6
  • 153
    • 70350096110 scopus 로고    scopus 로고
    • Construction of a DNA vaccine encoding Flk-1 extracellular domain and C3d fusion gene and investigation of its suppressing effect on tumor growth
    • Liang, P.H., Zhang, K.Q., Xu, G.L., Li, Y.F., Wang, L.F., Nie, Z.L., et al. Construction of a DNA vaccine encoding Flk-1 extracellular domain and C3d fusion gene and investigation of its suppressing effect on tumor growth. Cancer Immunol Immunother 59:1 (2010), 93–101.
    • (2010) Cancer Immunol Immunother , vol.59 , Issue.1 , pp. 93-101
    • Liang, P.H.1    Zhang, K.Q.2    Xu, G.L.3    Li, Y.F.4    Wang, L.F.5    Nie, Z.L.6
  • 154
    • 75649099783 scopus 로고    scopus 로고
    • Phase I clinical trial using peptide vaccine for human vascular endothelial growth factor receptor 2 in combination with gemcitabine for patients with advanced pancreatic cancer
    • Miyazawa, M., Ohsawa, R., Tsunoda, T., Hirono, S., Kawai, M., Tani, M., et al. Phase I clinical trial using peptide vaccine for human vascular endothelial growth factor receptor 2 in combination with gemcitabine for patients with advanced pancreatic cancer. Cancer Sci 101:2 (2010), 433–439.
    • (2010) Cancer Sci , vol.101 , Issue.2 , pp. 433-439
    • Miyazawa, M.1    Ohsawa, R.2    Tsunoda, T.3    Hirono, S.4    Kawai, M.5    Tani, M.6
  • 155
    • 0035678089 scopus 로고    scopus 로고
    • Identification of a novel membrane protein, HP59, with therapeutic potential as a target of tumor angiogenesis
    • Fu, C., Bardhan, S., Cetateanu, N.D., Wamil, B.D., Wang, Y., Yan, H.-P., et al. Identification of a novel membrane protein, HP59, with therapeutic potential as a target of tumor angiogenesis. Clin Cancer Res 7:12 (2001), 4182–4194.
    • (2001) Clin Cancer Res , vol.7 , Issue.12 , pp. 4182-4194
    • Fu, C.1    Bardhan, S.2    Cetateanu, N.D.3    Wamil, B.D.4    Wang, Y.5    Yan, H.-P.6
  • 156
    • 38949193901 scopus 로고    scopus 로고
    • Effective inhibition of the epidermal growth factor/epidermal growth factor receptor binding by anti-epidermal growth factor antibodies is related to better survival in advanced non-small-cell lung cancer patients treated with the epidermal growth factor cancer vaccine
    • García, B., Neninger, E., de la Torre, A., Leonard, I., Martínez, R., Viada, C., et al. Effective inhibition of the epidermal growth factor/epidermal growth factor receptor binding by anti-epidermal growth factor antibodies is related to better survival in advanced non-small-cell lung cancer patients treated with the epidermal growth factor cancer vaccine. Clin Cancer Res 14:3 (2008), 840–846.
    • (2008) Clin Cancer Res , vol.14 , Issue.3 , pp. 840-846
    • García, B.1    Neninger, E.2    de la Torre, A.3    Leonard, I.4    Martínez, R.5    Viada, C.6
  • 158
    • 85015605572 scopus 로고    scopus 로고
    • Combination therapy in cancer: effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics
    • Nerini, I.F., Cesca, M., Bizzaro, F., Giavazzi, R., Combination therapy in cancer: effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics. Chin J Cancer, 35(1), 2016, 61.
    • (2016) Chin J Cancer , vol.35 , Issue.1 , pp. 61
    • Nerini, I.F.1    Cesca, M.2    Bizzaro, F.3    Giavazzi, R.4
  • 159
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain, R.K., Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307:5706 (2005), 58–62.
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 160
    • 0036569804 scopus 로고    scopus 로고
    • Enhancement of radiation therapy by the novel vascular targeting agent ZD6126
    • Siemann, D.W., Rojiani, A.M., Enhancement of radiation therapy by the novel vascular targeting agent ZD6126. Int J Radiat Oncol Biol Phys 53:1 (2002), 164–171.
    • (2002) Int J Radiat Oncol Biol Phys , vol.53 , Issue.1 , pp. 164-171
    • Siemann, D.W.1    Rojiani, A.M.2
  • 161
    • 84971606511 scopus 로고    scopus 로고
    • Tumor resistance to vascular disrupting agents: mechanisms, imaging, and solutions
    • Liang, W., Ni, Y., Chen, F., Tumor resistance to vascular disrupting agents: mechanisms, imaging, and solutions. Oncotarget 7:13 (2016), 15444–15459.
    • (2016) Oncotarget , vol.7 , Issue.13 , pp. 15444-15459
    • Liang, W.1    Ni, Y.2    Chen, F.3
  • 162
    • 33748869678 scopus 로고    scopus 로고
    • Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies
    • Horsman, M.R., Siemann, D.W., Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies. Can Res 66:24 (2006), 11520–11539.
    • (2006) Can Res , vol.66 , Issue.24 , pp. 11520-11539
    • Horsman, M.R.1    Siemann, D.W.2
  • 163
    • 77956301345 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate: a novel vascular disrupting agent
    • Nagaiah, G., Remick, S.C., Combretastatin A4 phosphate: a novel vascular disrupting agent. Future Oncol 6:8 (2010), 1219–1228.
    • (2010) Future Oncol , vol.6 , Issue.8 , pp. 1219-1228
    • Nagaiah, G.1    Remick, S.C.2
  • 164
    • 77949534041 scopus 로고    scopus 로고
    • Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma
    • Kłosowska-Wardęga, A., Hasumi, Y., Burmakin, M., Åhgren, A., Stuhr, L., Moen, I., et al. Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma. PLoS ONE, 4(12), 2009, e8149.
    • (2009) PLoS ONE , vol.4 , Issue.12 , pp. e8149
    • Kłosowska-Wardęga, A.1    Hasumi, Y.2    Burmakin, M.3    Åhgren, A.4    Stuhr, L.5    Moen, I.6
  • 165
    • 84938634617 scopus 로고    scopus 로고
    • Intratumoral pharmacokinetics: challenges to nanobiomaterials
    • Al-Abd, A.M., Al-Abbasi, F.A., Torchilin, V.P., Intratumoral pharmacokinetics: challenges to nanobiomaterials. Curr Pharm Des 21:22 (2015), 3208–3214.
    • (2015) Curr Pharm Des , vol.21 , Issue.22 , pp. 3208-3214
    • Al-Abd, A.M.1    Al-Abbasi, F.A.2    Torchilin, V.P.3
  • 166
    • 34948862788 scopus 로고    scopus 로고
    • Sequence dependent antitumour efficacy of the vascular disrupting agent ZD6126 in combination with paclitaxel
    • Martinelli, M., Bonezzi, K., Riccardi, E., Kuhn, E., Frapolli, R., Zucchetti, M., et al. Sequence dependent antitumour efficacy of the vascular disrupting agent ZD6126 in combination with paclitaxel. Br J Cancer 97:7 (2007), 888–894.
    • (2007) Br J Cancer , vol.97 , Issue.7 , pp. 888-894
    • Martinelli, M.1    Bonezzi, K.2    Riccardi, E.3    Kuhn, E.4    Frapolli, R.5    Zucchetti, M.6
  • 167
    • 34447121919 scopus 로고    scopus 로고
    • Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy
    • Dickson, P.V., Hamner, J.B., Sims, T.L., Fraga, C.H., Ng, C.Y., Rajasekeran, S., et al. Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy. Clin Cancer Res 13:13 (2007), 3942–3950.
    • (2007) Clin Cancer Res , vol.13 , Issue.13 , pp. 3942-3950
    • Dickson, P.V.1    Hamner, J.B.2    Sims, T.L.3    Fraga, C.H.4    Ng, C.Y.5    Rajasekeran, S.6
  • 168
    • 84870450397 scopus 로고    scopus 로고
    • Metronomic chemotherapy in combination with antiangiogenic treatment induces mosaic vascular reduction and tumor growth inhibition in hepatocellular carcinoma xenografts
    • Zhou, F., Hu, J., Shao, J.-H., Zou, S.-B., Shen, S.-L., Luo, Z.-Q., Metronomic chemotherapy in combination with antiangiogenic treatment induces mosaic vascular reduction and tumor growth inhibition in hepatocellular carcinoma xenografts. J Cancer Res Clin Oncol 138:11 (2012), 1879–1890.
    • (2012) J Cancer Res Clin Oncol , vol.138 , Issue.11 , pp. 1879-1890
    • Zhou, F.1    Hu, J.2    Shao, J.-H.3    Zou, S.-B.4    Shen, S.-L.5    Luo, Z.-Q.6
  • 169
    • 84948464406 scopus 로고    scopus 로고
    • Combined inhibition of IL1, CXCR1/2, and TGFβ signaling pathways modulates in-vivo resistance to anti-VEGF treatment
    • Carbone, C., Tamburrino, A., Piro, G., Boschi, F., Cataldo, I., Zanotto, M., et al. Combined inhibition of IL1, CXCR1/2, and TGFβ signaling pathways modulates in-vivo resistance to anti-VEGF treatment. Anticancer Drugs 27:1 (2016), 29–40.
    • (2016) Anticancer Drugs , vol.27 , Issue.1 , pp. 29-40
    • Carbone, C.1    Tamburrino, A.2    Piro, G.3    Boschi, F.4    Cataldo, I.5    Zanotto, M.6
  • 170
    • 57749092182 scopus 로고    scopus 로고
    • Combination of antiangiogenesis with chemotherapy for more effective cancer treatment
    • Ma, J., Waxman, D.J., Combination of antiangiogenesis with chemotherapy for more effective cancer treatment. Mol Cancer Ther 7:12 (2008), 3670–3684.
    • (2008) Mol Cancer Ther , vol.7 , Issue.12 , pp. 3670-3684
    • Ma, J.1    Waxman, D.J.2
  • 171
    • 84890549535 scopus 로고    scopus 로고
    • Combination antiangiogenic therapy and radiation in head and neck cancers
    • Hsu, H.-W., Wall, N.R., Hsueh, C.-T., Kim, S., Ferris, R.L., Chen, C.-S., et al. Combination antiangiogenic therapy and radiation in head and neck cancers. Oral Oncol 50:1 (2014), 19–26.
    • (2014) Oral Oncol , vol.50 , Issue.1 , pp. 19-26
    • Hsu, H.-W.1    Wall, N.R.2    Hsueh, C.-T.3    Kim, S.4    Ferris, R.L.5    Chen, C.-S.6
  • 172
    • 70349976708 scopus 로고    scopus 로고
    • Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: the three musketeers or just another quixotic combination?
    • Kamrava, M., Bernstein, M.B., Camphausen, K., Hodge, J.W., Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: the three musketeers or just another quixotic combination?. Mol BioSyst 5:11 (2009), 1262–1270.
    • (2009) Mol BioSyst , vol.5 , Issue.11 , pp. 1262-1270
    • Kamrava, M.1    Bernstein, M.B.2    Camphausen, K.3    Hodge, J.W.4
  • 173
    • 0031443206 scopus 로고    scopus 로고
    • A cancer therapy resistant to resistance
    • Kerbel, R.S., A cancer therapy resistant to resistance. Nature 390:6658 (1997), 335–336.
    • (1997) Nature , vol.390 , Issue.6658 , pp. 335-336
    • Kerbel, R.S.1
  • 174
    • 0025717523 scopus 로고
    • Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents
    • Kerbel, R.S., Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. BioEssays 13:1 (1991), 31–36.
    • (1991) BioEssays , vol.13 , Issue.1 , pp. 31-36
    • Kerbel, R.S.1
  • 175
    • 77955887676 scopus 로고    scopus 로고
    • Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303)
    • Kindler, H.L., Niedzwiecki, D., Hollis, D., Sutherland, S., Schrag, D., Hurwitz, H., et al. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J Clin Oncol 28:22 (2010), 3617–3622.
    • (2010) J Clin Oncol , vol.28 , Issue.22 , pp. 3617-3622
    • Kindler, H.L.1    Niedzwiecki, D.2    Hollis, D.3    Sutherland, S.4    Schrag, D.5    Hurwitz, H.6
  • 176
    • 35648941728 scopus 로고    scopus 로고
    • Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study
    • Saltz, L.B., Lenz, H.-J., Kindler, H.L., Hochster, H.S., Wadler, S., Hoff, P.M., et al. Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study. J Clin Oncol 25:29 (2007), 4557–4561.
    • (2007) J Clin Oncol , vol.25 , Issue.29 , pp. 4557-4561
    • Saltz, L.B.1    Lenz, H.-J.2    Kindler, H.L.3    Hochster, H.S.4    Wadler, S.5    Hoff, P.M.6
  • 177
    • 34547820876 scopus 로고    scopus 로고
    • Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+ Gr1+ myeloid cells
    • Shojaei, F., Wu, X., Malik, A.K., Zhong, C., Baldwin, M.E., Schanz, S., et al. Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+ Gr1+ myeloid cells. Nat Biotechnol 25:8 (2007), 911–920.
    • (2007) Nat Biotechnol , vol.25 , Issue.8 , pp. 911-920
    • Shojaei, F.1    Wu, X.2    Malik, A.K.3    Zhong, C.4    Baldwin, M.E.5    Schanz, S.6
  • 178
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers, G., Hanahan, D., Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8:8 (2008), 592–603.
    • (2008) Nat Rev Cancer , vol.8 , Issue.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 179
    • 40949148520 scopus 로고    scopus 로고
    • Tumor escape from endogenous, extracellular matrix–associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors
    • Fernando, N.T., Koch, M., Rothrock, C., Gollogly, L.K., D'Amore, P.A., Ryeom, S., et al. Tumor escape from endogenous, extracellular matrix–associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors. Clin Cancer Res 14:5 (2008), 1529–1539.
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1529-1539
    • Fernando, N.T.1    Koch, M.2    Rothrock, C.3    Gollogly, L.K.4    D'Amore, P.A.5    Ryeom, S.6
  • 180
    • 24744438663 scopus 로고    scopus 로고
    • Induction of interleukin-8 preserves the angiogenic response in HIF-1α–deficient colon cancer cells
    • Mizukami, Y., Jo, W.-S., Duerr, E.-M., Gala, M., Li, J., Zhang, X., et al. Induction of interleukin-8 preserves the angiogenic response in HIF-1α–deficient colon cancer cells. Nat Med 11:9 (2005), 992–997.
    • (2005) Nat Med , vol.11 , Issue.9 , pp. 992-997
    • Mizukami, Y.1    Jo, W.-S.2    Duerr, E.-M.3    Gala, M.4    Li, J.5    Zhang, X.6
  • 181
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor, T.T., Sorensen, A.G., di Tomaso, E., Zhang, W.-T., Duda, D.G., Cohen, K.S., et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11:1 (2007), 83–95.
    • (2007) Cancer Cell , vol.11 , Issue.1 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di Tomaso, E.3    Zhang, W.-T.4    Duda, D.G.5    Cohen, K.S.6
  • 182
    • 0031019745 scopus 로고    scopus 로고
    • Isolation of putative progenitor endothelial cells for angiogenesis
    • Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275:5302 (1997), 964–966.
    • (1997) Science , vol.275 , Issue.5302 , pp. 964-966
    • Asahara, T.1    Murohara, T.2    Sullivan, A.3    Silver, M.4    van der Zee, R.5    Li, T.6
  • 183
    • 26944437515 scopus 로고    scopus 로고
    • PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
    • Song, S., Ewald, A.J., Stallcup, W., Werb, Z., Bergers, G., PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol 7:9 (2005), 870–879.
    • (2005) Nat Cell Biol , vol.7 , Issue.9 , pp. 870-879
    • Song, S.1    Ewald, A.J.2    Stallcup, W.3    Werb, Z.4    Bergers, G.5
  • 184
    • 5444225991 scopus 로고    scopus 로고
    • Expansion of myeloid immune suppressor Gr+ CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
    • Yang, L., DeBusk, L.M., Fukuda, K., Fingleton, B., Green-Jarvis, B., Shyr, Y., et al. Expansion of myeloid immune suppressor Gr+ CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell 6:4 (2004), 409–421.
    • (2004) Cancer Cell , vol.6 , Issue.4 , pp. 409-421
    • Yang, L.1    DeBusk, L.M.2    Fukuda, K.3    Fingleton, B.4    Green-Jarvis, B.5    Shyr, Y.6
  • 185
    • 33749005405 scopus 로고    scopus 로고
    • Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors
    • Shaked, Y., Ciarrocchi, A., Franco, M., Lee, C.R., Man, S., Cheung, A.M., et al. Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science 313:5794 (2006), 1785–1787.
    • (2006) Science , vol.313 , Issue.5794 , pp. 1785-1787
    • Shaked, Y.1    Ciarrocchi, A.2    Franco, M.3    Lee, C.R.4    Man, S.5    Cheung, A.M.6
  • 186
    • 33749441325 scopus 로고    scopus 로고
    • Rapid vascular regrowth in tumors after reversal of VEGF inhibition
    • Mancuso, M.R., Davis, R., Norberg, S.M., O'Brien, S., Sennino, B., Nakahara, T., et al. Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest 116:10 (2006), 2610–2621.
    • (2006) J Clin Invest , vol.116 , Issue.10 , pp. 2610-2621
    • Mancuso, M.R.1    Davis, R.2    Norberg, S.M.3    O'Brien, S.4    Sennino, B.5    Nakahara, T.6
  • 188
    • 0031834239 scopus 로고    scopus 로고
    • A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
    • Benjamin, L.E., Hemo, I., Keshet, E., A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 125:9 (1998), 1591–1598.
    • (1998) Development , vol.125 , Issue.9 , pp. 1591-1598
    • Benjamin, L.E.1    Hemo, I.2    Keshet, E.3
  • 189
    • 0242456268 scopus 로고    scopus 로고
    • Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival
    • Darland, D., Massingham, L., Smith, S., Piek, E., Saint-Geniez, M., D'amore, P., Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Dev Biol 264:1 (2003), 275–288.
    • (2003) Dev Biol , vol.264 , Issue.1 , pp. 275-288
    • Darland, D.1    Massingham, L.2    Smith, S.3    Piek, E.4    Saint-Geniez, M.5    D'amore, P.6
  • 190
    • 60649116273 scopus 로고    scopus 로고
    • Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival: clinical article
    • Narayana, A., Kelly, P., Golfinos, J., Parker, E., Johnson, G., Knopp, E., et al. Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival: clinical article. J Neurosurg 110:1 (2009), 173–180.
    • (2009) J Neurosurg , vol.110 , Issue.1 , pp. 173-180
    • Narayana, A.1    Kelly, P.2    Golfinos, J.3    Parker, E.4    Johnson, G.5    Knopp, E.6
  • 191
    • 41649112610 scopus 로고    scopus 로고
    • Bevacizumab for recurrent malignant gliomas Efficacy, toxicity, and patterns of recurrence
    • Norden, A., Young, G., Setayesh, K., Muzikansky, A., Klufas, R., Ross, G., et al. Bevacizumab for recurrent malignant gliomas Efficacy, toxicity, and patterns of recurrence. Neurology 70:10 (2008), 779–787.
    • (2008) Neurology , vol.70 , Issue.10 , pp. 779-787
    • Norden, A.1    Young, G.2    Setayesh, K.3    Muzikansky, A.4    Klufas, R.5    Ross, G.6
  • 192
    • 84964685809 scopus 로고    scopus 로고
    • Resistance to antiangiogenic therapies by metabolic symbiosis in renal cell carcinoma PDX models and patients
    • Jimenez-Valerio, G., Martinez-Lozano, M., Bassani, N., Vidal, A., Ochoa-de-Olza, M., Suarez, C., et al. Resistance to antiangiogenic therapies by metabolic symbiosis in renal cell carcinoma PDX models and patients. Cell Rep 15:6 (2016), 1134–1143.
    • (2016) Cell Rep , vol.15 , Issue.6 , pp. 1134-1143
    • Jimenez-Valerio, G.1    Martinez-Lozano, M.2    Bassani, N.3    Vidal, A.4    Ochoa-de-Olza, M.5    Suarez, C.6
  • 193
    • 20444479863 scopus 로고    scopus 로고
    • Differential diagnosis of pancreatic tumors using ultrasound contrast imaging
    • Sofuni, A., Iijima, H., Moriyasu, F., Nakayama, D., Shimizu, M., Nakamura, K., et al. Differential diagnosis of pancreatic tumors using ultrasound contrast imaging. J Gastroenterol 40:5 (2005), 518–525.
    • (2005) J Gastroenterol , vol.40 , Issue.5 , pp. 518-525
    • Sofuni, A.1    Iijima, H.2    Moriyasu, F.3    Nakayama, D.4    Shimizu, M.5    Nakamura, K.6
  • 194
    • 9144247005 scopus 로고    scopus 로고
    • Genetic and hypoxic regulation of angiogenesis in gliomas
    • Kaur, B., Tan, C., Brat, D.J., Genetic and hypoxic regulation of angiogenesis in gliomas. J Neurooncol 70:2 (2004), 229–243.
    • (2004) J Neurooncol , vol.70 , Issue.2 , pp. 229-243
    • Kaur, B.1    Tan, C.2    Brat, D.J.3
  • 195
    • 42549173671 scopus 로고    scopus 로고
    • The potential of anti-vascular endothelial growth factor therapy in metastatic breast cancer: clinical experience with anti-angiogenic agents, focusing on bevacizumab
    • Marty, M., Pivot, X., The potential of anti-vascular endothelial growth factor therapy in metastatic breast cancer: clinical experience with anti-angiogenic agents, focusing on bevacizumab. Eur J Cancer 44:7 (2008), 912–920.
    • (2008) Eur J Cancer , vol.44 , Issue.7 , pp. 912-920
    • Marty, M.1    Pivot, X.2
  • 196
    • 34250195797 scopus 로고    scopus 로고
    • Therapeutic approaches of angiogenesis inhibition: are we tackling the problem at the right level?
    • Griffioen, A.W., Therapeutic approaches of angiogenesis inhibition: are we tackling the problem at the right level?. Trends Cardiovasc Med 17:5 (2007), 171–176.
    • (2007) Trends Cardiovasc Med , vol.17 , Issue.5 , pp. 171-176
    • Griffioen, A.W.1
  • 197
    • 16644394469 scopus 로고    scopus 로고
    • Can tumor angiogenesis be inhibited without resistance?
    • Miller, K.D., Sweeney, C.J., Sledge, G.W. Jr, Can tumor angiogenesis be inhibited without resistance?. EXS 94 (2005), 95–112.
    • (2005) EXS , vol.94 , pp. 95-112
    • Miller, K.D.1    Sweeney, C.J.2    Sledge, G.W.3
  • 198
    • 0030242225 scopus 로고    scopus 로고
    • Fighting cancer by attacking its blood supply
    • Folkman, J., Fighting cancer by attacking its blood supply. Sci Am 275:3 (1996), 150–154.
    • (1996) Sci Am , vol.275 , Issue.3 , pp. 150-154
    • Folkman, J.1
  • 199
    • 85017413453 scopus 로고    scopus 로고
    • Antiangiogenic therapy combined with immune checkpoint blockade in renal cancer
    • Kuusk, T., Albiges, L., Escudier, B., Grivas, N., Haanen, J., Powles, T., et al. Antiangiogenic therapy combined with immune checkpoint blockade in renal cancer. Angiogenesis 20:2 (2017), 205–215.
    • (2017) Angiogenesis , vol.20 , Issue.2 , pp. 205-215
    • Kuusk, T.1    Albiges, L.2    Escudier, B.3    Grivas, N.4    Haanen, J.5    Powles, T.6
  • 200
    • 85018487408 scopus 로고    scopus 로고
    • The androgen receptor and VEGF: mechanisms of androgen-regulated angiogenesis in prostate cancer
    • Eisermann, K., Fraizer, G., The androgen receptor and VEGF: mechanisms of androgen-regulated angiogenesis in prostate cancer. Cancers (Basel), 9(4), 2017.
    • (2017) Cancers (Basel) , vol.9 , Issue.4
    • Eisermann, K.1    Fraizer, G.2
  • 201
    • 84959465512 scopus 로고    scopus 로고
    • Future options of anti-angiogenic cancer therapy
    • Cao, Y., Future options of anti-angiogenic cancer therapy. Chin J Cancer, 35, 2016, 21.
    • (2016) Chin J Cancer , vol.35 , pp. 21
    • Cao, Y.1


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