메뉴 건너뛰기




Volumn 7, Issue 9, 2005, Pages 870-879

PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; UNCLASSIFIED DRUG;

EID: 26944437515     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1288     Document Type: Article
Times cited : (484)

References (43)
  • 2
    • 0242405617 scopus 로고    scopus 로고
    • Endothelial-pericyte interactions in angiogenesis
    • Gerhardt, H. & Betsholtz, C. Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res. 314, 15-23 (2003).
    • (2003) Cell Tissue Res. , vol.314 , pp. 15-23
    • Gerhardt, H.1    Betsholtz, C.2
  • 3
    • 0038714289 scopus 로고    scopus 로고
    • Endothelial signaling during development
    • Cleaver, O. & Melton, D. A. Endothelial signaling during development. Nature Med. 9, 661-668 (2003).
    • (2003) Nature Med. , vol.9 , pp. 661-668
    • Cleaver, O.1    Melton, D.A.2
  • 4
    • 0030270961 scopus 로고    scopus 로고
    • Pericytes in the microvasculature
    • Hirschi, K. K. & D'Amore, P. A. Pericytes in the microvasculature. Cardiovasc. Res. 32, 687-698 (1996).
    • (1996) Cardiovasc. Res. , vol.32 , pp. 687-698
    • Hirschi, K.K.1    D'Amore, P.A.2
  • 5
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers, G. & Benjamin, L. E. Tumorigenesis and the angiogenic switch. Nature Rev. Cancer 3, 401-410 (2003).
    • (2003) Nature Rev. Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 6
    • 0034648793 scopus 로고    scopus 로고
    • Vascular-specific growth factors and blood vessel formation
    • Yancopoulos, G. D. et al. Vascular-specific growth factors and blood vessel formation. Nature 407, 242-248 (2000).
    • (2000) Nature , vol.407 , pp. 242-248
    • Yancopoulos, G.D.1
  • 7
    • 16644381982 scopus 로고    scopus 로고
    • Role of pericytes in vascular morphogenesis
    • Betsholtz, C., Lindblom, P. & Gerhardt, H. Role of pericytes in vascular morphogenesis. EXS 94, 115-125 (2005).
    • (2005) EXS , vol.94 , pp. 115-125
    • Betsholtz, C.1    Lindblom, P.2    Gerhardt, H.3
  • 8
    • 1942504107 scopus 로고    scopus 로고
    • Early contribution of pericytes to angiogenic sprouting and tube formation
    • Ozerdem, U. & Stallcup, W. B. Early contribution of pericytes to angiogenic sprouting and tube formation. Angiogenesis 6, 241-249 (2003).
    • (2003) Angiogenesis , vol.6 , pp. 241-249
    • Ozerdem, U.1    Stallcup, W.B.2
  • 9
    • 0032482202 scopus 로고    scopus 로고
    • PDGF, TGF-β, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate
    • Hirschi, K. K., Rohovsky, S. A. & D'Amore, P. A. PDGF, TGF-β, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate. J. Cell Biol. 141, 805-814 (1998).
    • (1998) J. Cell Biol. , vol.141 , pp. 805-814
    • Hirschi, K.K.1    Rohovsky, S.A.2    D'Amore, P.A.3
  • 10
    • 0032768156 scopus 로고    scopus 로고
    • Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    • Hellstrom, M., Kalen, M., Lindahl, P., Abramsson, A. & Betsholtz, C. Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 126, 3047-3055 (1999).
    • (1999) Development , vol.126 , pp. 3047-3055
    • Hellstrom, M.1    Kalen, M.2    Lindahl, P.3    Abramsson, A.4    Betsholtz, C.5
  • 11
    • 0034989658 scopus 로고    scopus 로고
    • Developmental roles of platelet-derived growth factors
    • Betsholtz, C., Karlsson, L. & Lindahl, P. Developmental roles of platelet-derived growth factors. Bioessays 23, 494-507 (2001).
    • (2001) Bioessays , vol.23 , pp. 494-507
    • Betsholtz, C.1    Karlsson, L.2    Lindahl, P.3
  • 12
    • 0027936261 scopus 로고
    • Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities
    • Leveen, P. et al. Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes Dev. 8, 1875-1887 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 1875-1887
    • Leveen, P.1
  • 13
    • 27144492550 scopus 로고    scopus 로고
    • Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    • Lindahl, P., Johansson, B., Leveen, P. & Betsholtz, C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 126, 3047-3055 (1997).
    • (1997) Science , vol.126 , pp. 3047-3055
    • Lindahl, P.1    Johansson, B.2    Leveen, P.3    Betsholtz, C.4
  • 14
    • 0035972251 scopus 로고    scopus 로고
    • Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    • Hellstrom, M. et al. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J. Cell Biol. 153, 543-553 (2001).
    • (2001) J. Cell Biol. , vol.153 , pp. 543-553
    • Hellstrom, M.1
  • 15
    • 18544366585 scopus 로고    scopus 로고
    • Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy
    • Enge, M. et al. Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO J. 21, 4307-4316 (2002).
    • (2002) EMBO J. , vol.21 , pp. 4307-4316
    • Enge, M.1
  • 16
    • 0032973230 scopus 로고    scopus 로고
    • Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact
    • Hirschi, K. K., Rohovsky, S. A., Beck, L. H., Smith, S. R. & D'Amore, P. A. Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact. Circ. Res. 84, 298-305 (1999).
    • (1999) Circ. Res. , vol.84 , pp. 298-305
    • Hirschi, K.K.1    Rohovsky, S.A.2    Beck, L.H.3    Smith, S.R.4    D'Amore, P.A.5
  • 17
    • 3343011406 scopus 로고    scopus 로고
    • NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and α3β1 integrin
    • Fukushi, J., Makagiansar, I. T. & Stallcup, W. B. NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and α3β1 integrin. Mol. Biol. Cell 15, 3580-3590 (2004).
    • (2004) Mol. Biol. Cell , vol.15 , pp. 3580-3590
    • Fukushi, J.1    Makagiansar, I.T.2    Stallcup, W.B.3
  • 18
    • 0031834239 scopus 로고    scopus 로고
    • A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
    • Benjamin, L., Hemo, I. & Keshet, E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 125, 1591-1598 (1998).
    • (1998) Development , vol.125 , pp. 1591-1598
    • Benjamin, L.1    Hemo, I.2    Keshet, E.3
  • 19
    • 0036124520 scopus 로고    scopus 로고
    • Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
    • Morikawa, S. et al. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am. J. Pathol. 160, 985-1000 (2002).
    • (2002) Am. J. Pathol. , vol.160 , pp. 985-1000
    • Morikawa, S.1
  • 20
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers, G., Song, S., Meyer-Morse, N., Bergsland, E. & Hanahan, D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. 111, 1287-1295 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 21
    • 0035347301 scopus 로고    scopus 로고
    • Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival
    • Reinmuth, N. et al. Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival. Faseb. J. 15, 1239-1241 (2001).
    • (2001) Faseb. J. , vol.15 , pp. 1239-1241
    • Reinmuth, N.1
  • 22
    • 0035866334 scopus 로고    scopus 로고
    • Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms
    • Shaheen, R. M. et al. Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms. Cancer Res. 61, 1464-1468 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 1464-1468
    • Shaheen, R.M.1
  • 23
    • 0032875460 scopus 로고    scopus 로고
    • Mechanism of action and in vivo role of platelet-derived growth factor
    • Heldin, C. H. & Westermark, B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 79, 1283-1316 (1999).
    • (1999) Physiol. Rev. , vol.79 , pp. 1283-1316
    • Heldin, C.H.1    Westermark, B.2
  • 24
    • 2942682933 scopus 로고    scopus 로고
    • Insight into the physiological functions of PDGF through genetic studies in mice
    • Betsholtz, C. Insight into the physiological functions of PDGF through genetic studies in mice. Cytokine Growth Factor Rev. 15, 215-218 (2004).
    • (2004) Cytokine Growth Factor Rev. , vol.15 , pp. 215-218
    • Betsholtz, C.1
  • 25
    • 0030005902 scopus 로고    scopus 로고
    • Antiangiogenic therapy of transgenic mice impairs de novo tumor growth
    • Parangi, S. et al. Antiangiogenic therapy of transgenic mice impairs de novo tumor growth. Proc. Natl Acad. Sci. USA 93, 2002-2007 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2002-2007
    • Parangi, S.1
  • 26
    • 0031771470 scopus 로고    scopus 로고
    • Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis
    • Bergers, G., Hanahan, D. & Coussens, L. M. Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis. Int. J. Dev. Biol. 42, 995-1002 (1998).
    • (1998) Int. J. Dev. Biol. , vol.42 , pp. 995-1002
    • Bergers, G.1    Hanahan, D.2    Coussens, L.M.3
  • 27
    • 0345505671 scopus 로고    scopus 로고
    • Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells
    • Bondjers, C. et al. Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells. Am. J. Pathol. 162, 721-729 (2003).
    • (2003) Am. J. Pathol. , vol.162 , pp. 721-729
    • Bondjers, C.1
  • 28
    • 0037365902 scopus 로고    scopus 로고
    • Pericyte-specific expression of Rgs5: Implications for PDGF and EDG receptor signaling during vascular maturation
    • Cho, H., Kozasa, T., Bondjers, C., Betsholtz, C. & Kehrl, J. H. Pericyte-specific expression of Rgs5: Implications for PDGF and EDG receptor signaling during vascular maturation. Faseb. J. 17, 440-442 (2003).
    • (2003) Faseb. J. , vol.17 , pp. 440-442
    • Cho, H.1    Kozasa, T.2    Bondjers, C.3    Betsholtz, C.4    Kehrl, J.H.5
  • 29
    • 2642533612 scopus 로고    scopus 로고
    • Integrin β3 overexpression suppresses tumor growth in a human model of gliomagenesis: Implications for the role of β3 overexpression in glioblastoma multiforme
    • Kanamori, M., Vanden Berg, S. R., Bergers, G., Berger, M. S. & Pieper, R. O. Integrin β3 overexpression suppresses tumor growth in a human model of gliomagenesis: Implications for the role of β3 overexpression in glioblastoma multiforme. Cancer Res. 64, 2751-2758 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 2751-2758
    • Kanamori, M.1    Vanden Berg, S.R.2    Bergers, G.3    Berger, M.S.4    Pieper, R.O.5
  • 30
    • 3843094218 scopus 로고    scopus 로고
    • Angiopoietin 1, PDGF-B, and TGF-β gene regulation in endothelial cell and smooth muscle cell interaction
    • Nishishita, T. & Lin, P. C. Angiopoietin 1, PDGF-B, and TGF-β gene regulation in endothelial cell and smooth muscle cell interaction. J. Cell. Biochem. 91, 584-593 (2004).
    • (2004) J. Cell. Biochem. , vol.91 , pp. 584-593
    • Nishishita, T.1    Lin, P.C.2
  • 31
    • 0035236215 scopus 로고    scopus 로고
    • Cell-cell interactions in vascular development
    • Darland, D. C. & D'Amore, P. A. Cell-cell interactions in vascular development. Curr. Top. Dev. Biol. 52, 107-149 (2001).
    • (2001) Curr. Top. Dev. Biol. , vol.52 , pp. 107-149
    • Darland, D.C.1    D'Amore, P.A.2
  • 32
    • 2442716332 scopus 로고    scopus 로고
    • Transforming growth factor-β-induced differentiation of smooth muscle from a neural crest stem cell line
    • Chen, S. & Lechleider, R. J. Transforming growth factor-β-induced differentiation of smooth muscle from a neural crest stem cell line. Circ. Res. 94, 1195-1202 (2004).
    • (2004) Circ. Res. , vol.94 , pp. 1195-1202
    • Chen, S.1    Lechleider, R.J.2
  • 33
    • 4644295385 scopus 로고    scopus 로고
    • Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells
    • Rajantie, I. et al. Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells. Blood 104, 2084-2086 (2004).
    • (2004) Blood , vol.104 , pp. 2084-2086
    • Rajantie, I.1
  • 34
    • 8144221439 scopus 로고    scopus 로고
    • Endothelial-mesenchymal interactions in vitro reveal molecular mechanisms of smooth muscle/pericyte differentiation
    • Ding, R., Darland, D. C., Parmacek, M. S. & D'Amore, P. A. Endothelial-mesenchymal interactions in vitro reveal molecular mechanisms of smooth muscle/pericyte differentiation. Stem Cells Dev. 13, 509-520 (2004).
    • (2004) Stem Cells Dev. , vol.13 , pp. 509-520
    • Ding, R.1    Darland, D.C.2    Parmacek, M.S.3    D'Amore, P.A.4
  • 35
    • 0036140857 scopus 로고    scopus 로고
    • Analysis of mural cell recruitment to tumor vessels
    • Abramsson, A. et al. Analysis of mural cell recruitment to tumor vessels. Circulation 105, 112-117 (2002).
    • (2002) Circulation , vol.105 , pp. 112-117
    • Abramsson, A.1
  • 36
    • 0035160312 scopus 로고    scopus 로고
    • Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
    • Lyden, D. et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nature Med. 7, 1194-1201 (2001).
    • (2001) Nature Med. , vol.7 , pp. 1194-1201
    • Lyden, D.1
  • 37
    • 0037358570 scopus 로고    scopus 로고
    • Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization
    • Rabbany, S. Y., Heissig, B., Hattori, K. & Rafii, S. Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization. Trends Mol. Med. 9, 109-117 (2003).
    • (2003) Trends Mol. Med. , vol.9 , pp. 109-117
    • Rabbany, S.Y.1    Heissig, B.2    Hattori, K.3    Rafii, S.4
  • 38
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • [see comments]
    • Benjamin, L. E., Golijanin, D., Itin, A., Pode, D. & Keshet, E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal [see comments]. J. Clin. Invest. 103, 159-165 (1999).
    • (1999) J. Clin. Invest. , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 39
    • 14644446018 scopus 로고    scopus 로고
    • A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
    • Pietras, K. & Hanahan, D. A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J. Clin. Oncol. 23, 939-952 (2004).
    • (2004) J. Clin. Oncol. , vol.23 , pp. 939-952
    • Pietras, K.1    Hanahan, D.2
  • 40
    • 0034796499 scopus 로고    scopus 로고
    • NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis
    • Ozerdem, U., Grako, K. A., Dahlin-Huppe, K., Monosov, E. & Stallcup, W. B. NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis. Dev. Dyn. 222, 218-227 (2001).
    • (2001) Dev. Dyn. , vol.222 , pp. 218-227
    • Ozerdem, U.1    Grako, K.A.2    Dahlin-Huppe, K.3    Monosov, E.4    Stallcup, W.B.5
  • 41
    • 0029833679 scopus 로고    scopus 로고
    • The rise and fall of apoptosis during multistage tumorigenesis: Down-modulation contributes to progression from angiogenic progenitors
    • Naik, P., Karrim, J. & Hanahan, D. The rise and fall of apoptosis during multistage tumorigenesis: Down-modulation contributes to progression from angiogenic progenitors. Genes Dev. 10, 2105-2116 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 2105-2116
    • Naik, P.1    Karrim, J.2    Hanahan, D.3
  • 42
    • 0026677532 scopus 로고
    • HMEC-1: Establishment of an immortalized human microvascular endothelial cell line
    • Ades, E. W. et al. HMEC-1: Establishment of an immortalized human microvascular endothelial cell line. J. Invest. Dermatol. 99, 683-690 (1992).
    • (1992) J. Invest. Dermatol. , vol.99 , pp. 683-690
    • Ades, E.W.1
  • 43
    • 0027299925 scopus 로고
    • Pancreatic β cells cultured from individual preneoplastic foci in a multistage tumorigenesis pathway: A potentially general technique for isolating physiologically representative cell lines
    • Radvanyi, F., Christgau, S., Baekkeskov, S., Jolicoeur, C. & Hanahan, D. Pancreatic β cells cultured from individual preneoplastic foci in a multistage tumorigenesis pathway: A potentially general technique for isolating physiologically representative cell lines. Mol. Cell. Biol. 13, 4223-4232 (1993).
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4223-4232
    • Radvanyi, F.1    Christgau, S.2    Baekkeskov, S.3    Jolicoeur, C.4    Hanahan, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.