-
1
-
-
84969308022
-
Phase II study of first-line trebananib plus sorafenib in patients with advanced hepatocellular carcinoma (HCC) [Abstract]
-
Abou-Alfa, G. K., Blanc, J. F., Miles, S., Ganten, T. M., Trojan, J., Cebon, J. S., et al. (2014). Phase II study of first-line trebananib plus sorafenib in patients with advanced hepatocellular carcinoma (HCC) [Abstract]. J. Clin. Oncol. 32(Suppl. 3), 286.
-
(2014)
J. Clin. Oncol
, vol.32
, pp. 286
-
-
Abou-Alfa, G.K.1
Blanc, J.F.2
Miles, S.3
Ganten, T.M.4
Trojan, J.5
Cebon, J.S.6
-
2
-
-
33646586669
-
Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor
-
Albert, D. H., Tapang, P., Magoc, T. J., Pease, L. J., Reuter, D. R., Wei, R. Q., et al. (2006). Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol. Cancer Ther. 5, 995-1006. doi: 10.1158/1535-7163.MCT-05-0410
-
(2006)
Mol. Cancer Ther
, vol.5
, pp. 995-1006
-
-
Albert, D.H.1
Tapang, P.2
Magoc, T.J.3
Pease, L.J.4
Reuter, D.R.5
Wei, R.Q.6
-
3
-
-
84864348077
-
Cediranib (AZD2171) in patients with advanced hepatocellular carcinoma: a phase II north central cancer treatment group clinical trial
-
Alberts, S. R., Fitch, T. R., Kim, G. P., Morlan, B. W., Dakhil, S. R., Gross, H. M., et al. (2012). Cediranib (AZD2171) in patients with advanced hepatocellular carcinoma: a phase II north central cancer treatment group clinical trial. Am. J. Clin. Oncol. 35, 329-333. doi: 10.1097/COC.0b013e3182118cdf
-
(2012)
Am. J. Clin. Oncol
, vol.35
, pp. 329-333
-
-
Alberts, S.R.1
Fitch, T.R.2
Kim, G.P.3
Morlan, B.W.4
Dakhil, S.R.5
Gross, H.M.6
-
4
-
-
84875609144
-
Sorafenib in combination with transarterial chemoembolization improves the survival of patients with unresectable hepatocellular carcinoma: a propensity score matching study
-
Bai, W., Wang, Y. J., Zhao, Y., Qi, X. S., Yin, Z. X., He, C. Y., et al. (2013). Sorafenib in combination with transarterial chemoembolization improves the survival of patients with unresectable hepatocellular carcinoma: a propensity score matching study. J. Dig. Dis. 14, 181-190. doi: 10.1111/1751-2980.12038
-
(2013)
J. Dig. Dis
, vol.14
, pp. 181-190
-
-
Bai, W.1
Wang, Y.J.2
Zhao, Y.3
Qi, X.S.4
Yin, Z.X.5
He, C.Y.6
-
5
-
-
84888214777
-
Colorectal cancer in elderly patients: from best supportive care to cure
-
Berretta, M., Di Benedetto, F., Di Francia, R., Lo Menzo, E., Palmeri, S., Tirelli, U., et al. (2013). Colorectal cancer in elderly patients: from best supportive care to cure. Anticancer Agents Med. Chem. 13, 1332-1343. doi: 10.2174/18715206113136660350
-
(2013)
Anticancer Agents Med. Chem
, vol.13
, pp. 1332-1343
-
-
Berretta, M.1
Di Benedetto, F.2
Di Francia, R.3
Lo Menzo, E.4
Palmeri, S.5
Tirelli, U.6
-
6
-
-
84969410505
-
New entities in the treatment of hepatocellular carcinoma: HIV-positive and elderly patients
-
Berretta, M., Di Francia, R., Di Benedetto, F., and Tirelli, U. (2015a). New entities in the treatment of hepatocellular carcinoma: HIV-positive and elderly patients. WCRJ 2, e558.
-
(2015)
WCRJ
, vol.2
-
-
Berretta, M.1
Di Francia, R.2
Di Benedetto, F.3
Tirelli, U.4
-
7
-
-
84919712660
-
Editorial-The new oncologic challenges in the 3rd millennium
-
Berretta, M., Di Francia, R., and Tirelli, U. (2014). Editorial-The new oncologic challenges in the 3rd millennium. WCRJ 1, e133
-
(2014)
WCRJ
, vol.1
-
-
Berretta, M.1
Di Francia, R.2
Tirelli, U.3
-
8
-
-
84942324213
-
Sorafenib combined with percutaneous radiofrequency ablation for the treatment of medium-sized hepatocellular carcinoma
-
Berretta, M., Di Francia, R., and Tirelli, U. (2015b). Sorafenib combined with percutaneous radiofrequency ablation for the treatment of medium-sized hepatocellular carcinoma. Eur. Rev. Med. Pharmacol. Sci. 19, 2521-2522.
-
(2015)
Eur. Rev. Med. Pharmacol. Sci
, vol.19
, pp. 2521-2522
-
-
Berretta, M.1
Di Francia, R.2
Tirelli, U.3
-
9
-
-
80053187997
-
Hepatocellular carcinoma in HIV-infected patients: check early, treat hard
-
Berretta, M., Garlassi, E., Cacopardo, B., Cappellani, A., Guaraldi, G., Cocchi, S., et al. (2011). Hepatocellular carcinoma in HIV-infected patients: check early, treat hard. Oncologist16, 1258-1269. doi: 10.1634/theoncologist.2010-0400
-
(2011)
Oncologist
, vol.16
, pp. 1258-1269
-
-
Berretta, M.1
Garlassi, E.2
Cacopardo, B.3
Cappellani, A.4
Guaraldi, G.5
Cocchi, S.6
-
10
-
-
84958044481
-
Clinical presentation and outcome of non-AIDS defining cancer, in HIV-infected patients in the ART-era:the Italian Cooperative Group on AIDS and tumors activity
-
Berretta, M., Martellotta, F., Di Francia, R., Spina, M., Vaccher, E., Balestreri, L., et al. (2015c). Clinical presentation and outcome of non-AIDS defining cancer, in HIV-infected patients in the ART-era:the Italian Cooperative Group on AIDS and tumors activity. Eur. Rev. Med. Pharmacol. Sci. 19, 3619-3634.
-
(2015)
Eur. Rev. Med. Pharmacol. Sci
, vol.19
, pp. 3619-3634
-
-
Berretta, M.1
Martellotta, F.2
Di Francia, R.3
Spina, M.4
Vaccher, E.5
Balestreri, L.6
-
11
-
-
84969428573
-
Primary liver cancer: clinical aspects, prognostic factors and predictive response to therapy
-
Berretta, S., Fisichella, R., Spartà, D., Lleshi, A., and Nasti, G. (2015). Primary liver cancer: clinical aspects, prognostic factors and predictive response to therapy. WCRJ 2:e561.
-
(2015)
WCRJ
, vol.2
-
-
Berretta, S.1
Fisichella, R.2
Spartà, D.3
Lleshi, A.4
Nasti, G.5
-
12
-
-
84865208483
-
Efficacy, safety, and biomarkers of single-agent bevacizumab therapy in patients with advanced hepatocellular carcinoma
-
Boige, V., Malka, D., Bourredjem, A., Dromain, C., Baey, C., Jacques, N., et al. (2012). Efficacy, safety, and biomarkers of single-agent bevacizumab therapy in patients with advanced hepatocellular carcinoma. Oncologist 17, 1063-1072. doi: 10.1634/theoncologist.2011-0465
-
(2012)
Oncologist
, vol.17
, pp. 1063-1072
-
-
Boige, V.1
Malka, D.2
Bourredjem, A.3
Dromain, C.4
Baey, C.5
Jacques, N.6
-
13
-
-
84898767802
-
Hepatocellular carcinoma: clinical frontiers and perspectives
-
Bruix, J., Gores, G. J., and Mazzaferro, V. (2014a). Hepatocellular carcinoma: clinical frontiers and perspectives. Gut 63, 844-855. doi: 10.1136/gutjnl-2013-306627
-
(2014)
Gut
, vol.63
, pp. 844-855
-
-
Bruix, J.1
Gores, G.J.2
Mazzaferro, V.3
-
14
-
-
84907023733
-
STORM Investigators. STORM: a phase III randomized, double-blind, placebo-controlled trial of adjuvant sorafenib after resection or ablation to prevent recurrence of hepatocellular carcinoma (HCC) [Abstract]
-
Bruix, J., Takayama, T., Mazzaferro, V., Chau, G.-Y., Yang, J., Kudo, M., et al. (2014b). STORM Investigators. STORM: a phase III randomized, double-blind, placebo-controlled trial of adjuvant sorafenib after resection or ablation to prevent recurrence of hepatocellular carcinoma (HCC) [Abstract]. J. Clin. Oncol. 32(5s Suppl.):4006.
-
(2014)
J. Clin. Oncol
, vol.32
, Issue.5
, pp. 4006
-
-
Bruix, J.1
Takayama, T.2
Mazzaferro, V.3
Chau, G.-Y.4
Yang, J.5
Kudo, M.6
-
15
-
-
84885173677
-
Regorafenib as second-line therapy for intermediate or advanced hepatocellular carcinoma: multicentre, open-label, phase II safety study
-
Bruix, J., Tak, W. Y., Gasbarrini, A., Santoro, A., Colombo, M., Lim, H. Y., et al. (2013). Regorafenib as second-line therapy for intermediate or advanced hepatocellular carcinoma: multicentre, open-label, phase II safety study. Eur. J. Cancer49, 3412-3419. doi: 10.1016/j.ejca.2013.05.028
-
(2013)
Eur. J. Cancer
, vol.49
, pp. 3412-3419
-
-
Bruix, J.1
Tak, W.Y.2
Gasbarrini, A.3
Santoro, A.4
Colombo, M.5
Lim, H.Y.6
-
16
-
-
84874222975
-
Phase 2 trial of concurrent bevacizumab and transhepatic arterial chemoembolization in patients with unresectable hepatocellular carcinoma
-
Buijs, M., Reyes, D. K., Pawlik, T. M., Blackford, A. L., Salem, R., Messersmith, W. A., et al. (2013). Phase 2 trial of concurrent bevacizumab and transhepatic arterial chemoembolization in patients with unresectable hepatocellular carcinoma. Cancer 119, 1042-1049. doi: 10.1002/cncr.27859
-
(2013)
Cancer
, vol.119
, pp. 1042-1049
-
-
Buijs, M.1
Reyes, D.K.2
Pawlik, T.M.3
Blackford, A.L.4
Salem, R.5
Messersmith, W.A.6
-
17
-
-
41149122199
-
Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo(2, 1-f)(1, 2, 4)triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor (BMS-540215)
-
Cai, Z. W., Zhang, Y., Borzilleri, R. M., Qian, L., Barbosa, S., Wei, D., et al. (2008). Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo(2, 1-f)(1, 2, 4)triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor (BMS-540215). J. Med. Chem. 51, 1976-1980. doi: 10.1021/jm7013309
-
(2008)
J. Med. Chem
, vol.51
, pp. 1976-1980
-
-
Cai, Z.W.1
Zhang, Y.2
Borzilleri, R.M.3
Qian, L.4
Barbosa, S.5
Wei, D.6
-
18
-
-
84920993186
-
Linifanib Sorafenib in patients with advanced hepatocellular carcinoma: results of a randomized phase III trial
-
Cainap, C., Qin, S., Huang, W. T., Chung, I. J., Pan, H., Cheng, Y., et al. (2015). Linifanib Sorafenib in patients with advanced hepatocellular carcinoma: results of a randomized phase III trial. J. Clin. Oncol. 33, 172-179. doi: 10.1200/JCO.2013.54.3298
-
(2015)
J. Clin. Oncol
, vol.33
, pp. 172-179
-
-
Cainap, C.1
Qin, S.2
Huang, W.T.3
Chung, I.J.4
Pan, H.5
Cheng, Y.6
-
19
-
-
84969434493
-
Hepatocellular carcinoma: an overvierw of clinic-pathological and molecular prespectives
-
Canzonieri, V., Alessandrini, L., Caggiari, L., Perin, T., Berretta, M., Cannizzaro, R., et al. (2015). Hepatocellular carcinoma: an overvierw of clinic-pathological and molecular prespectives. WCRJ 2:e485.
-
(2015)
WCRJ
, vol.2
-
-
Canzonieri, V.1
Alessandrini, L.2
Caggiari, L.3
Perin, T.4
Berretta, M.5
Cannizzaro, R.6
-
20
-
-
84864561983
-
Molecular mechanisms of sorafenib action in liver cancer cells
-
Cervello, M., Bacharov, D., Lampiasi, N., Cusimano, A., Azzolina, A., McCubrey, J. A., et al. (2012). Molecular mechanisms of sorafenib action in liver cancer cells. Cell Cycle 11, 2843-2855. doi: 10.4161/cc.21193
-
(2012)
Cell Cycle
, vol.11
, pp. 2843-2855
-
-
Cervello, M.1
Bacharov, D.2
Lampiasi, N.3
Cusimano, A.4
Azzolina, A.5
McCubrey, J.A.6
-
21
-
-
85003960832
-
Liver resection for HCC in HIV-infected patients: a single center experience
-
D'Amico, G., Tarantino, G., Ballarin, R., Serra, V., Pecchi, A. R., Guaraldi, G., et al. (2015a). Liver resection for HCC in HIV-infected patients: a single center experience. WCRJ 2:e490.
-
(2015)
WCRJ
, vol.2
-
-
D'Amico, G.1
Tarantino, G.2
Ballarin, R.3
Serra, V.4
Pecchi, A.R.5
Guaraldi, G.6
-
22
-
-
85043610448
-
Isolated caudate lobectomy for Spiegel lobe neoplasms
-
D'Amico, G., Tarantino, G., Serra, V., Ballarin, R., and Di Benedetto, F. (2015b). Isolated caudate lobectomy for Spiegel lobe neoplasms. WCRJ 2:e490.
-
(2015)
WCRJ
, vol.2
-
-
D'Amico, G.1
Tarantino, G.2
Serra, V.3
Ballarin, R.4
Di Benedetto, F.5
-
23
-
-
84872892692
-
GRID study investigators. GRID study investigators. Efficacy and safety of regorafenib for advanced gastroin inal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial
-
Demetri, G. D., Reichardt, P., Kang, Y. K., Blay, J. Y., Rutkowski, P., Gelderblom, H., et al. (2013). GRID study investigators. GRID study investigators. Efficacy and safety of regorafenib for advanced gastroin inal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 381, 295-302. doi: 10.1016/S0140-6736(12)61857-1
-
(2013)
Lancet
, vol.381
, pp. 295-302
-
-
Demetri, G.D.1
Reichardt, P.2
Kang, Y.K.3
Blay, J.Y.4
Rutkowski, P.5
Gelderblom, H.6
-
24
-
-
84942240333
-
Pharmacogenomics markers for prediction response and toxicity in cancer therapy
-
De Monaco, A., Faioli, D., Di Paolo, M., Catapano, O., D'Orta, A., Del Buono, M., et al. (2014). Pharmacogenomics markers for prediction response and toxicity in cancer therapy. WCRJ 1:e276.
-
(2014)
WCRJ
, vol.1
-
-
De Monaco, A.1
Faioli, D.2
Di Paolo, M.3
Catapano, O.4
D'Orta, A.5
Del Buono, M.6
-
25
-
-
83555174312
-
Is advanced hepatocellular carcinoma amenable of cure by liver transplantation with sorafenib as a neoadiuvant approach plus m-TOR inhibitors monotherapy?
-
Di Benedetto, F., Berretta, M., De Ruvo, N., Tarantino, G., D'Amico, G., Ballarin, R., et al. (2012). Is advanced hepatocellular carcinoma amenable of cure by liver transplantation with sorafenib as a neoadiuvant approach plus m-TOR inhibitors monotherapy? J. Surg. Oncol. 105, 111-112. doi: 10.1002/jso.22039
-
(2012)
J. Surg. Oncol
, vol.105
, pp. 111-112
-
-
Di Benedetto, F.1
Berretta, M.2
De Ruvo, N.3
Tarantino, G.4
D'Amico, G.5
Ballarin, R.6
-
26
-
-
40749132136
-
Hepatocellular carcinoma in HIV patients treated by liver transplsntation
-
Di Benedetto, F., De Ruvo, N., Berretta, M., Masetti, M., Montalti, R., Di Sandro, S., et al. (2008). Hepatocellular carcinoma in HIV patients treated by liver transplsntation. Eur. J. Surg. Oncol. 34, 422-427. doi: 10.1016/j.ejso.2007.05.004
-
(2008)
Eur. J. Surg. Oncol
, vol.34
, pp. 422-427
-
-
Di Benedetto, F.1
De Ruvo, N.2
Berretta, M.3
Masetti, M.4
Montalti, R.5
Di Sandro, S.6
-
27
-
-
84878171589
-
Multicenter Italian experience in liver transplantation for hepatocellular carcinoma in HIV-infected patients
-
Di Benedetto, F., Tarantino, G., Ercolani, G., Baccarani, U., Montalti, R., De Ruvo, N., et al. (2013b). Multicenter Italian experience in liver transplantation for hepatocellular carcinoma in HIV-infected patients. Oncologist 18, 592-599. doi: 10.1634/theoncologist.2012-0255
-
(2013)
Oncologist
, vol.18
, pp. 592-599
-
-
Di Benedetto, F.1
Tarantino, G.2
Ercolani, G.3
Baccarani, U.4
Montalti, R.5
De Ruvo, N.6
-
28
-
-
80053999294
-
Sorafenib before liver transplantation for hepatocellular carcinoma: risk or give up
-
Di Benedetto, F., Tarantino, G., Montalti, R., Ballarin, R., D'Amico, G., Berretta, M., et al. (2011). Sorafenib before liver transplantation for hepatocellular carcinoma: risk or give up. Transpl. Int. 24:e97. doi: 10.1111/j.1432-2277.2011.01329.x
-
(2011)
Transpl. Int
, vol.24
-
-
Di Benedetto, F.1
Tarantino, G.2
Montalti, R.3
Ballarin, R.4
D'Amico, G.5
Berretta, M.6
-
29
-
-
84888249701
-
Hepatocellular carcinoma: beyond the boundaries of age
-
Di Benedetto, F., Tarantino, G., Quintini, C., Tirelli, U., and Berretta, M. (2013a). Hepatocellular carcinoma: beyond the boundaries of age. Anticancer Agents Med. Chem. 13, 1371-1377. doi: 10.2174/18715206113136660342
-
(2013)
Anticancer Agents Med. Chem
, vol.13
, pp. 1371-1377
-
-
Di Benedetto, F.1
Tarantino, G.2
Quintini, C.3
Tirelli, U.4
Berretta, M.5
-
30
-
-
84897003991
-
Recurrent glioblastoma treated with bevacizumab: contrast-enhanced T1-weighted subtraction maps improve tumor delineation and aid prediction of survival in a multicenter clinical trial
-
Ellingson, B. M., Kim, H. J., Woodworth, D. C., Pope, W. B., Cloughesy, J. N., Harris, R. J., et al. (2014). Recurrent glioblastoma treated with bevacizumab: contrast-enhanced T1-weighted subtraction maps improve tumor delineation and aid prediction of survival in a multicenter clinical trial. Radiology 271, 200-210. doi: 10.1148/radiol.13131305
-
(2014)
Radiology
, vol.271
, pp. 200-210
-
-
Ellingson, B.M.1
Kim, H.J.2
Woodworth, D.C.3
Pope, W.B.4
Cloughesy, J.N.5
Harris, R.J.6
-
31
-
-
84875789255
-
Dual EGFR inhibition in combination with anti-VEGF treatment: a phase I clinical trial in non-small cell lung cancer
-
Falchook, G. S., Naing, A., Hong, D. S., Zinner, R., Fu, S., Piha-Paul, S. A., et al. (2013). Dual EGFR inhibition in combination with anti-VEGF treatment: a phase I clinical trial in non-small cell lung cancer. Oncotarget 4, 118-127. doi: 10.18632/oncotarget.763
-
(2013)
Oncotarget
, vol.4
, pp. 118-127
-
-
Falchook, G.S.1
Naing, A.2
Hong, D.S.3
Zinner, R.4
Fu, S.5
Piha-Paul, S.A.6
-
32
-
-
0037699954
-
The biology of VEGF and its receptors
-
Ferrara, N., Gerber, H. P., and LeCouter, J. (2003). The biology of VEGF and its receptors. Nat. Med. 9, 669-676. doi: 10.1038/nm0603-669
-
(2003)
Nat. Med
, vol.9
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
LeCouter, J.3
-
33
-
-
84857008164
-
Phase II, open-label study of brivanib as second-line therapy in patients with advanced hepatocellular carcinoma
-
Finn, R. S., Kang, Y. K., Mulcahy, M., Polite, B. N., Lim, H. Y., Walters, I., et al. (2012). Phase II, open-label study of brivanib as second-line therapy in patients with advanced hepatocellular carcinoma. Clin. Cancer Res. 18, 2090-2098. doi: 10.1158/1078-0432.CCR-11-1991
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 2090-2098
-
-
Finn, R.S.1
Kang, Y.K.2
Mulcahy, M.3
Polite, B.N.4
Lim, H.Y.5
Walters, I.6
-
34
-
-
84887993101
-
Phase I study investigating everolimus combined with sorafenib in patients with advanced hepatocellular carcinoma
-
Finn, R. S., Poon, R. T., Yau, T., Klümpen, H. J., Chen, L. T., Kang, Y. K., et al. (2013). Phase I study investigating everolimus combined with sorafenib in patients with advanced hepatocellular carcinoma. J. Hepatol. 59, 1271-1277. doi: 10.1016/j.jhep.2013.07.029
-
(2013)
J. Hepatol
, vol.59
, pp. 1271-1277
-
-
Finn, R.S.1
Poon, R.T.2
Yau, T.3
Klümpen, H.J.4
Chen, L.T.5
Kang, Y.K.6
-
35
-
-
84892852372
-
REGARD trial investigators. REGARD trial investigators. Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomized, multicentre, placebo-controlled, phase 3 trial
-
Fuchs, C. S., Tomasek, J., Yong, C. J., Dumitru, F., Passalacqua, R., Goswami, C., et al. (2014). REGARD trial investigators. REGARD trial investigators. Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomized, multicentre, placebo-controlled, phase 3 trial. Lancet 383, 31-39. doi: 10.1016/S0140-6736(13)61719-5
-
(2014)
Lancet
, vol.383
, pp. 31-39
-
-
Fuchs, C.S.1
Tomasek, J.2
Yong, C.J.3
Dumitru, F.4
Passalacqua, R.5
Goswami, C.6
-
36
-
-
84973293883
-
Mechanisms of adaptation of the hepatic vasculature to the deteriorating conditions of blood circulation in liver cirrhosis
-
Garbuzenko, D. V., Arefyev, N. O., and Belov, D. V. (2016). Mechanisms of adaptation of the hepatic vasculature to the deteriorating conditions of blood circulation in liver cirrhosis. World J. Hepatol. 8, 665-672. doi: 10.4254/wjh.v8.i16.665
-
(2016)
World J. Hepatol
, vol.8
, pp. 665-672
-
-
Garbuzenko, D.V.1
Arefyev, N.O.2
Belov, D.V.3
-
37
-
-
49649123154
-
BIBF 1120, triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
-
Hilberg, F., Roth, G. J., Krssak, M., Kautschitsch, S., Sommergruber, W., Tontsch-Grunt, U., et al. (2008). BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 68, 4774-4782. doi: 10.1158/0008-5472.CAN-07-6307
-
(2008)
Cancer Res
, vol.68
, pp. 4774-4782
-
-
Hilberg, F.1
Roth, G.J.2
Krssak, M.3
Kautschitsch, S.4
Sommergruber, W.5
Tontsch-Grunt, U.6
-
38
-
-
84991044084
-
Targeted and exome sequencing identified somatic mutations in hepatocellular carcinoma
-
Hirotsu, Y., Zheng, T.-H., Amemiya, K., Mochizuki, H., Guleng, B., and Omata, M. (2016). Targeted and exome sequencing identified somatic mutations in hepatocellular carcinoma. Hepatol. Res. 46, 1145-1151. doi: 10.1111/hepr.12663
-
(2016)
Hepatol. Res
, vol.46
, pp. 1145-1151
-
-
Hirotsu, Y.1
Zheng, T.-H.2
Amemiya, K.3
Mochizuki, H.4
Guleng, B.5
Omata, M.6
-
39
-
-
33646425826
-
New intra-arterial drug delivery system for the treatment of liver cancer: preclinical assessment in a rabbit model of liver cancer
-
Hong, K., Khwaja, A., Liapi, E., Torbenson, M. S., Georgiades, C. S., and Geschwind, J. F. (2006). New intra-arterial drug delivery system for the treatment of liver cancer: preclinical assessment in a rabbit model of liver cancer. Clin. Cancer Res. 12, 2563-2567. doi: 10.1158/1078-0432.CCR-05-2225
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 2563-2567
-
-
Hong, K.1
Khwaja, A.2
Liapi, E.3
Torbenson, M.S.4
Georgiades, C.S.5
Geschwind, J.F.6
-
40
-
-
84984578313
-
Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma
-
Hsu, C. H., Yang, T. S., Hsu, C., Toh, H. C., Epstein, R. J., Hsiao, L. T., et al. (2010). Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma. Br. J. Cancer 102, 981-986. doi: 10.1038/sj.bjc.6605580
-
(2010)
Br. J. Cancer
, vol.102
, pp. 981-986
-
-
Hsu, C.H.1
Yang, T.S.2
Hsu, C.3
Toh, H.C.4
Epstein, R.J.5
Hsiao, L.T.6
-
41
-
-
58149175849
-
Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma
-
Huynh, H., Ngo, V. C., Fargnoli, J., Ayers, M., Soo, K. C., Koong, H. N., et al. (2008). Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin. Cancer Res. 14, 6146-6153. doi: 10.1158/1078-0432.CCR-08-0509
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 6146-6153
-
-
Huynh, H.1
Ngo, V.C.2
Fargnoli, J.3
Ayers, M.4
Soo, K.C.5
Koong, H.N.6
-
42
-
-
70149119899
-
REDA119/BAY 869766, a potent, selective, allosteric inhibitor of MEK 1/2 for the treatment of cancer
-
Iverson, C., Larson, G., Lai, C., Yeh, L. T., Dadson, C., Weingarten, P., et al. (2009). REDA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK 1/2 for the treatment of cancer. Cancer Res. 69, 6839-6847. doi: 10.1158/0008-5472.CAN-09-0679
-
(2009)
Cancer Res
, vol.69
, pp. 6839-6847
-
-
Iverson, C.1
Larson, G.2
Lai, C.3
Yeh, L.T.4
Dadson, C.5
Weingarten, P.6
-
43
-
-
84890274647
-
Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL study
-
Johnson, P. J., Qin, S., Park, J. W., Poon, R. T., Raoul, J. L., Philip, P. A., et al. (2013). Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL study. J. Clin. Oncol. 31, 3517-3524. doi: 10.1200/JCO.2012.48.4410
-
(2013)
J. Clin. Oncol
, vol.31
, pp. 3517-3524
-
-
Johnson, P.J.1
Qin, S.2
Park, J.W.3
Poon, R.T.4
Raoul, J.L.5
Philip, P.A.6
-
44
-
-
84923267405
-
Evolution from WHO to EASL and RECIST for hepatocellular carcinoma: considerations for tumor response assessment
-
Kim, M. N., Kim, B. K., Han, K. H., and Kim, S. U. (2015). Evolution from WHO to EASL and RECIST for hepatocellular carcinoma: considerations for tumor response assessment. Expert Rev. Gastroenterol. Hepatol. 9, 335-348. doi: 10.1586/17474124.2015.959929
-
(2015)
Expert Rev. Gastroenterol. Hepatol
, vol.9
, pp. 335-348
-
-
Kim, M.N.1
Kim, B.K.2
Han, K.H.3
Kim, S.U.4
-
45
-
-
79957902010
-
Signal transduction by vascular endothelial growth factor receptors
-
Koch, S., Tugues, S., Li, X., Gualandi, L., and Claesson-Welsh, L. (2011). Signal transduction by vascular endothelial growth factor receptors. Biochem. J. 437, 169-183. doi: 10.1042/BJ20110301
-
(2011)
Biochem. J
, vol.437
, pp. 169-183
-
-
Koch, S.1
Tugues, S.2
Li, X.3
Gualandi, L.4
Claesson-Welsh, L.5
-
46
-
-
84862585045
-
Anti-VEGF strategies-from antibodies to tyrosine kinase inhibitors: background and clinical development in human cancer
-
Korpanty, G., and Smyth, E. (2012). Anti-VEGF strategies-from antibodies to tyrosine kinase inhibitors: background and clinical development in human cancer. Curr. Pharm. Des. 18, 2680-2701. doi: 10.2174/138161212800626166
-
(2012)
Curr. Pharm. Des
, vol.18
, pp. 2680-2701
-
-
Korpanty, G.1
Smyth, E.2
-
47
-
-
84982162814
-
Cancer-associated fibroblasts in hepatocellular carcinoma
-
Kubo, N., Araki, K., Kuwano, H., and Shirabe, K. (2016). Cancer-associated fibroblasts in hepatocellular carcinoma. World J. Gastroenterol. 22, 6841-6850. doi: 10.3748/wjg.v22.i30.6841
-
(2016)
World J. Gastroenterol
, vol.22
, pp. 6841-6850
-
-
Kubo, N.1
Araki, K.2
Kuwano, H.3
Shirabe, K.4
-
48
-
-
79952725305
-
Antitumor activity of BIBF 1120, a triple angiokinase inhibitor, and use of VEGFR2+pTyr+ peripheral blood leukocytes as a pharmacodynamic biomarker in vivo
-
Kudo, K., Arao, T., Tanaka, K., Nagai, T., Furuta, K., Sakai, K., et al. (2011). Antitumor activity of BIBF 1120, a triple angiokinase inhibitor, and use of VEGFR2+pTyr+ peripheral blood leukocytes as a pharmacodynamic biomarker in vivo. Clin. Cancer Res. 17, 1373-1381. doi: 10.1158/1078-0432.CCR-09-2755
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 1373-1381
-
-
Kudo, K.1
Arao, T.2
Tanaka, K.3
Nagai, T.4
Furuta, K.5
Sakai, K.6
-
49
-
-
77949264899
-
Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V study
-
Lammer, J., Malagari, K., Vogl, T., Pilleul, F., Denys, A., Watkinson, A., et al. (2010). Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V study. Cardiovasc. Intervent. Radiol. 33, 41-52. doi: 10.1007/s00270-009-9711-7
-
(2010)
Cardiovasc. Intervent. Radiol
, vol.33
, pp. 41-52
-
-
Lammer, J.1
Malagari, K.2
Vogl, T.3
Pilleul, F.4
Denys, A.5
Watkinson, A.6
-
50
-
-
84918777261
-
A phase II study of the efficacy and safety of the combination therapy of MEK inhibitor refametinib (BAY 86-9766) plus sorafenib for Asian patients with unresectable hepatocellular carcinoma
-
Lim, H. Y., Heo, J., Choi, H. J., Lin, C. Y., Yoon, J. H., Hsu, C., et al. (2014). A phase II study of the efficacy and safety of the combination therapy of MEK inhibitor refametinib (BAY 86-9766) plus sorafenib for Asian patients with unresectable hepatocellular carcinoma. Clin. Cancer Res. 20, 5976-5985. doi: 10.1158/1078-0432.CCR-13-3445
-
(2014)
Clin. Cancer Res
, vol.20
, pp. 5976-5985
-
-
Lim, H.Y.1
Heo, J.2
Choi, H.J.3
Lin, C.Y.4
Yoon, J.H.5
Hsu, C.6
-
51
-
-
84906822146
-
Liver cancer: time to evolve trial desi gn after everolimus failure
-
Llovet, J. M. (2014). Liver cancer: time to evolve trial desi gn after everolimus failure. Nat. Rev. Clin. Oncol. 11, 506-507. doi: 10.1038/nrclinonc.2014.136
-
(2014)
Nat. Rev. Clin. Oncol
, vol.11
, pp. 506-507
-
-
Llovet, J.M.1
-
52
-
-
0141491273
-
Hepatocellular carcinoma
-
Llovet, J. M., Burroughs, A., and Bruix, J. (2003). Hepatocellular carcinoma. Lancet 362, 1907-1917. doi: 10.1016/S0140-6736(03)14964-1
-
(2003)
Lancet
, vol.362
, pp. 1907-1917
-
-
Llovet, J.M.1
Burroughs, A.2
Bruix, J.3
-
53
-
-
84885587718
-
Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study
-
Llovet, J. M., Decaens, T., Raoul, J. L., Boucher, E., Kudo, M., Chang, C., et al. (2013). Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study. J. Clin. Oncol. 31, 3509-3516. doi: 10.1200/JCO.2012.47.3009
-
(2013)
J. Clin. Oncol
, vol.31
, pp. 3509-3516
-
-
Llovet, J.M.1
Decaens, T.2
Raoul, J.L.3
Boucher, E.4
Kudo, M.5
Chang, C.6
-
54
-
-
84898989382
-
Hepatocellular carcinoma: reasons for phase 3 failure and novel perspectives on trial design
-
Llovet, J. M., and Hernandez-Gea, V. (2014). Hepatocellular carcinoma: reasons for phase 3 failure and novel perspectives on trial design. Clin. Cancer Res. 20, 2072-2079. doi: 10.1158/1078-0432.CCR-13-0547
-
(2014)
Clin. Cancer Res
, vol.20
, pp. 2072-2079
-
-
Llovet, J.M.1
Hernandez-Gea, V.2
-
55
-
-
47949116252
-
SHARP investigators study group. Sorafenib in advanced hepatocellular carcinoma
-
Llovet, J. M., Ricci, S., Mazzaferro, V., Hilgard, P., Gane, E., Blanc, J. F., et al. (2008). SHARP investigators study group. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359, 378-390. doi: 10.1056/NEJMoa0708857
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
-
56
-
-
0036237822
-
Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma
-
Lo, C. M., Ngan, H., Tso, W. K., Liu, C. L., Lam, C. M., Poon, R. T., et al. (2002). Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology 35, 1164-1171. doi: 10.1053/jhep.2002.33156
-
(2002)
Hepatology
, vol.35
, pp. 1164-1171
-
-
Lo, C.M.1
Ngan, H.2
Tso, W.K.3
Liu, C.L.4
Lam, C.M.5
Poon, R.T.6
-
57
-
-
84928552893
-
Early hepatocellular carcinoma on the procrustean bed of ablation, resection, and transplantation
-
Mazzaferro, V., Lencioni, R., and Majno, P. (2014). Early hepatocellular carcinoma on the procrustean bed of ablation, resection, and transplantation. Semin. Liver Dis. 34, 415-426. doi: 10.1055/s-0034-1394365
-
(2014)
Semin. Liver Dis
, vol.34
, pp. 415-426
-
-
Mazzaferro, V.1
Lencioni, R.2
Majno, P.3
-
58
-
-
84903517779
-
Anti-angioprotein therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomized, multicentre, double-blind, placebo-controlled phase 3 trial
-
Monk, B. J., Poveda, A., Vergote, I., Raspagliesi, F., Fujiwara, K., Bae, D. S., et al. (2014). Anti-angioprotein therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomized, multicentre, double-blind, placebo-controlled phase 3 trial. Lancet Oncol. 15, 799-808. doi: 10.1016/S1470-2045(14)70244-X
-
(2014)
Lancet Oncol
, vol.15
, pp. 799-808
-
-
Monk, B.J.1
Poveda, A.2
Vergote, I.3
Raspagliesi, F.4
Fujiwara, K.5
Bae, D.S.6
-
59
-
-
79951558136
-
Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-a/5-fluorouracil therapy for hepatocellular carcinoma cells
-
Murakami, M., Kobayashi, S., Marubashi, S., Tomimaru, Y., Noda, T., Wada, H., et al. (2011). Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-a/5-fluorouracil therapy for hepatocellular carcinoma cells. Ann. Surg. Oncol. 18, 589-596. doi: 10.1245/s10434-010-1310-y
-
(2011)
Ann. Surg. Oncol
, vol.18
, pp. 589-596
-
-
Murakami, M.1
Kobayashi, S.2
Marubashi, S.3
Tomimaru, Y.4
Noda, T.5
Wada, H.6
-
60
-
-
84867972791
-
Hepatocellular carcinoma in HIV positive patients
-
Nunnari, G., Berretta, M., Pinzone, M. R., Di Rosa, M., Berretta, S., Cunsolo, G., et al. (2012). Hepatocellular carcinoma in HIV positive patients. Eur. Rev. Med. Pharmacol. Sci. 16, 1257-1270.
-
(2012)
Eur. Rev. Med. Pharmacol. Sci
, vol.16
, pp. 1257-1270
-
-
Nunnari, G.1
Berretta, M.2
Pinzone, M.R.3
Di Rosa, M.4
Berretta, S.5
Cunsolo, G.6
-
61
-
-
79953325932
-
Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma
-
Park, J. W., Finn, R. S., Kim, J. S., Karwal, M., Li, R. K., Ismail, F., et al. (2011). Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma. Clin. Cancer Res. 17, 1973-1983. doi: 10.1158/1078-0432.CCR-10-2011
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 1973-1983
-
-
Park, J.W.1
Finn, R.S.2
Kim, J.S.3
Karwal, M.4
Li, R.K.5
Ismail, F.6
-
62
-
-
80054722090
-
Phase II trial of sorafenib combined with concurrent transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma
-
Pawlik, T. M., Reyes, D. K., Cosgrove, D., Kamel, I. R., Bhagat, N., and Geschwind, J. F. (2011). Phase II trial of sorafenib combined with concurrent transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma. J. Clin. Oncol. 29, 3960-3967. doi: 10.1200/JCO.2011.37.1021
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 3960-3967
-
-
Pawlik, T.M.1
Reyes, D.K.2
Cosgrove, D.3
Kamel, I.R.4
Bhagat, N.5
Geschwind, J.F.6
-
63
-
-
79958742182
-
Everolimus augments the effects of sorafenib in a syngeneic orthotopic model of hepatocellular carcinoma
-
Piguet, A. C., Saar, B., Hlushchuk, R., St-Pierre, M. V., McSheehy, P. M., Radojevic, V., et al. (2011). Everolimus augments the effects of sorafenib in a syngeneic orthotopic model of hepatocellular carcinoma. Mol. Cancer Ther. 10, 1007-1017. doi: 10.1158/1535-7163.MCT-10-0666
-
(2011)
Mol. Cancer Ther
, vol.10
, pp. 1007-1017
-
-
Piguet, A.C.1
Saar, B.2
Hlushchuk, R.3
St-Pierre, M.V.4
McSheehy, P.M.5
Radojevic, V.6
-
64
-
-
75149112376
-
Single-center phase II trial of transarterial chemoembolization with drug-eluting beads for patients with unresectable hepatocellular carcinoma: initial experience in the United States
-
Reyes, D. K., Vossen, J. A., Kamel, I. R., Azad, N. S., Wahlin, T. A., Torbenson, M. S., et al. (2009). Single-center phase II trial of transarterial chemoembolization with drug-eluting beads for patients with unresectable hepatocellular carcinoma: initial experience in the United States. Cancer J. 15, 526-532. doi: 10.1097/PPO.0b013e3181c5214b
-
(2009)
Cancer J
, vol.15
, pp. 526-532
-
-
Reyes, D.K.1
Vossen, J.A.2
Kamel, I.R.3
Azad, N.S.4
Wahlin, T.A.5
Torbenson, M.S.6
-
65
-
-
0030952289
-
Mechanisms of angiogenesis
-
Risau, W. (1997). Mechanisms of angiogenesis. Nature 386, 671-674. doi: 10.1038/386671a0
-
(1997)
Nature
, vol.386
, pp. 671-674
-
-
Risau, W.1
-
66
-
-
34248591612
-
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
-
Roberts, P. J., and Der, C. J. (2007). Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 26, 3291-3310. doi: 10.1038/sj.onc.1210422
-
(2007)
Oncogene
, vol.26
, pp. 3291-3310
-
-
Roberts, P.J.1
Der, C.J.2
-
67
-
-
84919683248
-
A novel multiple tyrosine-kinase targeted agent to explore the future perspectives of anti-angiogenic therapy for the treatment of multiple solid tumors: cabozantinib
-
Roy, S., Narang, B. K., Rastogi, S. K., and Rawal, R. K. (2015). A novel multiple tyrosine-kinase targeted agent to explore the future perspectives of anti-angiogenic therapy for the treatment of multiple solid tumors: cabozantinib. Anticancer Agents Med. Chem. 15, 37-47. doi: 10.2174/1871520614666140902153840
-
(2015)
Anticancer Agents Med. Chem
, vol.15
, pp. 37-47
-
-
Roy, S.1
Narang, B.K.2
Rastogi, S.K.3
Rawal, R.K.4
-
68
-
-
84871721240
-
Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebocontrolled phase 2 study
-
Santoro, A., Rimassa, L., Borbath, I., Daniele, B., Salvagni, S., Van Laethem, J. L., et al. (2013). Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebocontrolled phase 2 study. Lancet Oncol. 14, 55-63. doi: 10.1016/S1470-2045(12)70490-4
-
(2013)
Lancet Oncol
, vol.14
, pp. 55-63
-
-
Santoro, A.1
Rimassa, L.2
Borbath, I.3
Daniele, B.4
Salvagni, S.5
Van Laethem, J.L.6
-
69
-
-
84922742421
-
Lenvatinib versus placebo in radioiodine-refractory thyroid cancer
-
Schlumberger, M., Tahara, M., Wirth, L. J., Robinson, B., Brose, M. S., Elisei, R., et al. (2015). Lenvatinib versus placebo in radioiodine-refractory thyroid cancer. N. Engl. J. Med. 372, 621-630. doi: 10.1056/NEJMoa1406470
-
(2015)
N. Engl. J. Med
, vol.372
, pp. 621-630
-
-
Schlumberger, M.1
Tahara, M.2
Wirth, L.J.3
Robinson, B.4
Brose, M.S.5
Elisei, R.6
-
70
-
-
84887093344
-
Allosteric MEK l/2 inhibitor refametinib (BAY 86-9766) in combination with sorafenib exhibits anti tumor activity in preclinical murine and rat models of hepatocellular carcinoma
-
Schmieder, R., Puehler, F., Neuhaus, R., Kissel, M., Adjei, A. A., Miner, J. N., et al. (2013). Allosteric MEK l/2 inhibitor refametinib (BAY 86-9766) in combination with sorafenib exhibits anti tumor activity in preclinical murine and rat models of hepatocellular carcinoma. Neoplasia 15, 1161-1171. doi: 10.1593/neo.13812
-
(2013)
Neoplasia
, vol.15
, pp. 1161-1171
-
-
Schmieder, R.1
Puehler, F.2
Neuhaus, R.3
Kissel, M.4
Adjei, A.A.5
Miner, J.N.6
-
71
-
-
0021111648
-
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
-
Senger, D. R., Galli, S. J., Dvorak, A. M., Perruzzi, C. A., Harvey, V. S., and Dvorak, H. F. (1983). Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219, 983-985.
-
(1983)
Science
, vol.219
, pp. 983-985
-
-
Senger, D.R.1
Galli, S.J.2
Dvorak, A.M.3
Perruzzi, C.A.4
Harvey, V.S.5
Dvorak, H.F.6
-
72
-
-
33344474964
-
Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
-
Shibuya, M., and Claesson-Welsh, L. (2006). Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp. Cell Res. 312, 549-560. doi: 10.1016/j.yexcr.2005.11.012
-
(2006)
Exp. Cell Res
, vol.312
, pp. 549-560
-
-
Shibuya, M.1
Claesson-Welsh, L.2
-
74
-
-
79959978255
-
Phase 2 trial of bevacizumab, capecitabine, and oxaliplatin in treatment of advanced hepatocellular carcinoma
-
Sun, W., Sohal, D., Haller, D. G., Mykulowycz, K., Rosen, M., Soulen, M. C., et al. (2011). Phase 2 trial of bevacizumab, capecitabine, and oxaliplatin in treatment of advanced hepatocellular carcinoma. Cancer 117, 3187-3192. doi: 10.1002/cncr.25889
-
(2011)
Cancer
, vol.117
, pp. 3187-3192
-
-
Sun, W.1
Sohal, D.2
Haller, D.G.3
Mykulowycz, K.4
Rosen, M.5
Soulen, M.C.6
-
75
-
-
84902662529
-
Nintedanib (BIBF-1120) inhibits hepatocellular carcinoma growth independent of angiokinase activity
-
Tai, W. T., Shiau, C. W., Li, Y. S., Chang, C. W., Huang, J. W., Hsueh, T. T., et al. (2014). Nintedanib (BIBF-1120) inhibits hepatocellular carcinoma growth independent of angiokinase activity. J. Hepatol. 61, 89-97. doi: 10.1016/j.jhep.2014.03.017
-
(2014)
J. Hepatol
, vol.61
, pp. 89-97
-
-
Tai, W.T.1
Shiau, C.W.2
Li, Y.S.3
Chang, C.W.4
Huang, J.W.5
Hsueh, T.T.6
-
76
-
-
0030044984
-
Vascular endothelial grouth factor, a potent and selective angiogenic agents
-
Thomas, K. A. (1996). Vascular endothelial grouth factor, a potent and selective angiogenic agents. J. Biol. Chem. 271, 603-606.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 603-606
-
-
Thomas, K.A.1
-
77
-
-
60849124241
-
Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma
-
Thomas, M. B., Morris, J. S., Chadha, R., Iwasaki, M., Kaur, H., Lin, E., et al. (2009). Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma. J. Clin. Oncol. 27, 843-850. doi: 10.1200/JCO.2008.18.3301
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 843-850
-
-
Thomas, M.B.1
Morris, J.S.2
Chadha, R.3
Iwasaki, M.4
Kaur, H.5
Lin, E.6
-
78
-
-
84984559340
-
Phase 2 trial of linifanib (ABT-869) in patients with unresectable or metastatic hepatocellular carcinoma
-
Toh, H. C., Chen, P. J., Carr, B. I., Knox, J. J., Gill, S., Ansell, P., et al. (2013). Phase 2 trial of linifanib (ABT-869) in patients with unresectable or metastatic hepatocellular carcinoma. Cancer 119, 380-387. doi: 10.1002/cncr.27758
-
(2013)
Cancer
, vol.119
, pp. 380-387
-
-
Toh, H.C.1
Chen, P.J.2
Carr, B.I.3
Knox, J.J.4
Gill, S.5
Ansell, P.6
-
79
-
-
84873458367
-
Radiotherapy and hepatocellular carcinoma: update and review of literature
-
Ursino, S., Greco, C., Cartei, F., Colosimo, C., Stefanelli, A., Caccopardo, B., et al. (2012). Radiotherapy and hepatocellular carcinoma: update and review of literature. Eur. Rev. Med. Pharmacol. Sci. 16, 1599-1604.
-
(2012)
Eur. Rev. Med. Pharmacol. Sci
, vol.16
, pp. 1599-1604
-
-
Ursino, S.1
Greco, C.2
Cartei, F.3
Colosimo, C.4
Stefanelli, A.5
Caccopardo, B.6
-
80
-
-
33846847728
-
Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics
-
Varela, M., Real, M. I., Burrel, M., Forner, A., Sala, M., Brunet, M., et al. (2007). Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics. J. Hepatol. 46, 474-481. doi: 10.1016/j.jhep.2006.10.020
-
(2007)
J. Hepatol
, vol.46
, pp. 474-481
-
-
Varela, M.1
Real, M.I.2
Burrel, M.3
Forner, A.4
Sala, M.5
Brunet, M.6
-
81
-
-
0034650802
-
Regulation of angiogenesis via vascular endothelial growth factor receptors
-
Veikkola, T., Karkkainen, M., Claesson-Weish, L., and Alitalo, K. (2000). Regulation of angiogenesis via vascular endothelial growth factor receptors. Cancer Res. 60, 203-212.
-
(2000)
Cancer Res
, vol.60
, pp. 203-212
-
-
Veikkola, T.1
Karkkainen, M.2
Claesson-Weish, L.3
Alitalo, K.4
-
82
-
-
84872549428
-
Activity of cabozantinib (XL184) in hepatocellular carcinoma: Results from a phase II randomized discontinuation trial (RDT) [Abstract]
-
Verslype, C., Cohn, A. L., Kelley, R. K., Yang, T. S., Su, W. C., Ramies, D. A., et al. (2012). Activity of cabozantinib (XL184) in hepatocellular carcinoma: Results from a phase II randomized discontinuation trial (RDT) [Abstract]. J. Clin. Oncol. 30(Suppl.):4007.
-
(2012)
J. Clin. Oncol
, vol.30
, pp. 4007
-
-
Verslype, C.1
Cohn, A.L.2
Kelley, R.K.3
Yang, T.S.4
Su, W.C.5
Ramies, D.A.6
-
83
-
-
84959537002
-
Regulation of signaling events involved in the pathophysiology of neovascular AMD
-
Wang, H., and Hartnett, M. E. (2016). Regulation of signaling events involved in the pathophysiology of neovascular AMD. Mol. Vis. 22, 189-202.
-
(2016)
Mol. Vis
, vol.22
, pp. 189-202
-
-
Wang, H.1
Hartnett, M.E.2
-
84
-
-
84908139963
-
RAINBOW Study Group. Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomized phase 3 trial
-
Wilke, H., Muro, K., Van Cutsem, E., Oh, S. C., Bodoky, G., Shimada, Y., et al. (2014). RAINBOW Study Group. RAINBOW Study Group. Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomized phase 3 trial. Lancet Oncol. 15, 1224-1235. doi: 10.1016/S1470-2045(14)70420-6
-
(2014)
Lancet Oncol
, vol.15
, pp. 1224-1235
-
-
Wilke, H.1
Muro, K.2
Van Cutsem, E.3
Oh, S.C.4
Bodoky, G.5
Shimada, Y.6
-
85
-
-
0034655182
-
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
-
Wood, J. M., Bold, G., Buchdunger, E., Cozens, R., Ferrari, S., Frei, J., et al. (2000). PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 60, 2178-2189.
-
(2000)
Cancer Res
, vol.60
, pp. 2178-2189
-
-
Wood, J.M.1
Bold, G.2
Buchdunger, E.3
Cozens, R.4
Ferrari, S.5
Frei, J.6
-
86
-
-
84901747256
-
Cabozantinib suppresses tumor growth and metastasis in hepatocellular carcinoma by a dual blockade of VEGFR2 and MET
-
Xiang, Q., Chen, W., Ren, M., Wang, J., Zhang, H., Deng, D. Y., et al. (2014). Cabozantinib suppresses tumor growth and metastasis in hepatocellular carcinoma by a dual blockade of VEGFR2 and MET. Clin. Cancer Res. 20, 2959-2970. doi: 10.1158/1078-0432.CCR-13-2620
-
(2014)
Clin. Cancer Res
, vol.20
, pp. 2959-2970
-
-
Xiang, Q.1
Chen, W.2
Ren, M.3
Wang, J.4
Zhang, H.5
Deng, D.Y.6
-
87
-
-
78249288161
-
Phase 1-2 trial of PTK787/ZK222584 combined with intravenous doxorubicin for treatment of patients with advanced hepatocellular carcinoma: implication for antiangiogenic approach to hepatocellular carcinoma
-
Yau, T., Chan, P., Pang, R., Ng, K., Fan, S. T., and Poon, R. T. (2010). Phase 1-2 trial of PTK787/ZK222584 combined with intravenous doxorubicin for treatment of patients with advanced hepatocellular carcinoma: implication for antiangiogenic approach to hepatocellular carcinoma. Cancer 116, 5022-5029. doi: 10.1002/cncr.25372
-
(2010)
Cancer
, vol.116
, pp. 5022-5029
-
-
Yau, T.1
Chan, P.2
Pang, R.3
Ng, K.4
Fan, S.T.5
Poon, R.T.6
-
88
-
-
79952054688
-
Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in hepatocellular carcinoma cells
-
Yi, Z. Y., Feng, L. J., Xiang, Z., and Yao, H. (2011). Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in hepatocellular carcinoma cells. J. Invest. Surg. 24, 67-76. doi: 10.3109/08941939.2010.542272
-
(2011)
J. Invest. Surg
, vol.24
, pp. 67-76
-
-
Yi, Z.Y.1
Feng, L.J.2
Xiang, Z.3
Yao, H.4
-
89
-
-
2542556259
-
Involvement of the vascular endothelial growth factor receptor-1 in murine hepatocellular carcinoma development
-
Yoshiji, H., Kuriyama, S., Yoshii, J., Ikenaka, Y., Noguchi, R., Yanase, K., et al. (2004). Involvement of the vascular endothelial growth factor receptor-1 in murine hepatocellular carcinoma development. J. Hepatol. 41, 97-103. doi: 10.1016/j.jhep.2004.03.001
-
(2004)
J. Hepatol
, vol.41
, pp. 97-103
-
-
Yoshiji, H.1
Kuriyama, S.2
Yoshii, J.3
Ikenaka, Y.4
Noguchi, R.5
Yanase, K.6
-
90
-
-
84918825536
-
Hepatocellular carcinoma in chronic HBV-HCV co-infection is correlated to fibrosis and disease duration
-
Zampino, R., Pisaturo, M. A., Cirillo, G., Marrone, A., Macera, M., Rinaldi, L., et al. (2015). Hepatocellular carcinoma in chronic HBV-HCV co-infection is correlated to fibrosis and disease duration. Ann. Hepatol. 14, 75-82.
-
(2015)
Ann. Hepatol
, vol.14
, pp. 75-82
-
-
Zampino, R.1
Pisaturo, M.A.2
Cirillo, G.3
Marrone, A.4
Macera, M.5
Rinaldi, L.6
-
91
-
-
84880732021
-
Sorafenib combined with transarterial chemoembolization for the treatment of advanced hepatocellular carcinoma: a large-scale multicenter study of 222 patients
-
Zhao, Y., Wang, W. J., Guan, S., Li, H. L., Xu, R. C., Wu, J. B., et al. (2013). Sorafenib combined with transarterial chemoembolization for the treatment of advanced hepatocellular carcinoma: a large-scale multicenter study of 222 patients. Ann. Oncol. 24, 1786-1792. doi: 10.1093/annonc/mdt072
-
(2013)
Ann. Oncol
, vol.24
, pp. 1786-1792
-
-
Zhao, Y.1
Wang, W.J.2
Guan, S.3
Li, H.L.4
Xu, R.C.5
Wu, J.B.6
-
92
-
-
33746624000
-
Systemic therapy of advanced hepatocellular carcinoma: how hopeful should we be?
-
Zhu, A. X. (2006). Systemic therapy of advanced hepatocellular carcinoma: how hopeful should we be? Oncologist 11, 790-800. doi: 10.1634/theoncologist.11-7-790
-
(2006)
Oncologist
, vol.11
, pp. 790-800
-
-
Zhu, A.X.1
-
93
-
-
84875181434
-
Efficacy, safety, pharmacokinetics, and biomarkers of cediranib monotherapy in advanced hepatocellular carcinoma: a phase II study
-
Zhu, A. X., Ancukiewicz, M., Supko, J. G., Sahani, D. V., Blaszkowsky, L. S., Meyerhardt, J. A., et al. (2013a). Efficacy, safety, pharmacokinetics, and biomarkers of cediranib monotherapy in advanced hepatocellular carcinoma: a phase II study. Clin. Cancer Res. 19, 1557-1566. doi: 10.1158/1078-0432.CCR-12-3041
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 1557-1566
-
-
Zhu, A.X.1
Ancukiewicz, M.2
Supko, J.G.3
Sahani, D.V.4
Blaszkowsky, L.S.5
Meyerhardt, J.A.6
-
94
-
-
33646351795
-
Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma
-
Zhu, A. X., Blaszkowsky, L. S., Ryan, D. P., Clark, J. W., Muzikansky, A., Horgan, K., et al. (2006). Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. J. Clin. Oncol. 24, 1898-1903. doi: 10.1200/JCO.2005.04.9130
-
(2006)
J. Clin. Oncol
, vol.24
, pp. 1898-1903
-
-
Zhu, A.X.1
Blaszkowsky, L.S.2
Ryan, D.P.3
Clark, J.W.4
Muzikansky, A.5
Horgan, K.6
-
95
-
-
79955580873
-
HCC and angiogenesis: possible targets and future directions
-
Zhu, A. X., Duda, D. G., Sahani, D. V., and Jain, R. K. (2011). HCC and angiogenesis: possible targets and future directions. Nat. Rev. Clin. Oncol. 8, 292-301. doi: 10.1038/nrclinonc.2011.30
-
(2011)
Nat. Rev. Clin. Oncol
, vol.8
, pp. 292-301
-
-
Zhu, A.X.1
Duda, D.G.2
Sahani, D.V.3
Jain, R.K.4
-
96
-
-
84890287907
-
A phase II and biomarker study of ramucirumab, a human monoclonal antibody targeting the VEGF receptor-2, as first-line monotherapy in patients with advanced hepatocellular cancer
-
Zhu, A. X., Finn, R. S., Mulcahy, M., Gurtler, J., Sun, W., Schwartz, J. D., et al. (2013b). A phase II and biomarker study of ramucirumab, a human monoclonal antibody targeting the VEGF receptor-2, as first-line monotherapy in patients with advanced hepatocellular cancer. Clin. Cancer Res. 19, 6614-6623. doi: 10.1158/1078-0432.CCR-13-1442
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 6614-6623
-
-
Zhu, A.X.1
Finn, R.S.2
Mulcahy, M.3
Gurtler, J.4
Sun, W.5
Schwartz, J.D.6
-
97
-
-
84898727950
-
EVOLVE-1: Phase 3 study of everolimus for advanced HCC that progressed during or after sorafenib [Abstract]
-
Zhu, A. X., Kudo, M., Assenat, E., Caltan, S., Kang, Y. K., Lim, Y., et al. (2014a). EVOLVE-1: Phase 3 study of everolimus for advanced HCC that progressed during or after sorafenib [Abstract]. J. Clin. Oncol. 32(Suppl. 3):172.
-
(2014)
J. Clin. Oncol
, vol.32
, pp. 172
-
-
Zhu, A.X.1
Kudo, M.2
Assenat, E.3
Caltan, S.4
Kang, Y.K.5
Lim, Y.6
-
98
-
-
84903593280
-
Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trial
-
Zhu, A. X., Kudo, M., Assenat, E., Cattan, S., Kang, Y. K., Lim, H. Y., et al. (2014b). Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trial. JAMA 312, 57-67. doi: 10.1001/jama.2014.7189
-
(2014)
JAMA
, vol.312
, pp. 57-67
-
-
Zhu, A.X.1
Kudo, M.2
Assenat, E.3
Cattan, S.4
Kang, Y.K.5
Lim, H.Y.6
-
99
-
-
84930461515
-
Ramucirumab (RAM) a second-line treatment in patients (pts) with advanced hepatocellular carcinoma (HCC): analysis of patients with elevated a-fetoprotein (AFP) from the randomized phase III REACH study [abstract]
-
Zhu, A. X., Ryoo, B.-Y., Yen, C.-J., Kudo, M., Poon, R. T.-P., Pastorelli, D., et al. (2015). Ramucirumab (RAM) a second-line treatment in patients (pts) with advanced hepatocellular carcinoma (HCC): analysis of patients with elevated a-fetoprotein (AFP) from the randomized phase III REACH study [abstract]. J. Clin. Oncol. 33(Suppl. 3):232.
-
(2015)
J. Clin. Oncol
, vol.33
, pp. 232
-
-
Zhu, A.X.1
Ryoo, B.-Y.2
Yen, C.-J.3
Kudo, M.4
Poon, R.T.-P.5
Pastorelli, D.6
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