Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Pratheeshkumar, Poyil ^a   Budhraja, Amit ^a   Son, Young Ok ^a   Wang, Xin ^a   Zhang, Zhuo ^a   Ding, Songze ^a   Wang, Lei ^a   Hitron, Andrew ^a   Lee, Jeong Chae ^a   Xu, Mei ^a   Chen, Gang ^a   Luo, Jia ^a   Shi, Xianglin ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN P70S6; PROTEIN SERINE THREONINE KINASE; QUERCETIN; S6 KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL TUBE FORMATION; CELL VIABILITY; CELLULAR PARAMETERS; CHICKEN EGG CHORIOALLANTOIC MEMBRANE ASSAY; CONTROLLED STUDY; DISEASE MODEL; DOWN REGULATION; DRUG DETERMINATION; DRUG TARGETING; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; EX VIVO STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MATRIGEL PLUG ASSAY; MICROVASCULATURE; MOUSE; NONHUMAN; PROSTATE TUMOR; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TUMOR VOLUME; TUMOR XENOGRAFT; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR RING; WESTERN BLOTTING;

ANGIOGENESIS INHIBITORS; ANIMALS; AORTA; APOPTOSIS; CELL LINE, TUMOR; CHICK EMBRYO; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MICE; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHORYLATION; PROSTATE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; QUERCETIN; RATS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84867651619     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047516     Document Type: Article

References (41)

1. Folkman J, Shing Y, (1992) Angiogenesis. J biol Chem 267: 10931-10934.
2. Risau W, (1997) Mechanisms of angiogenesis. Nature 386: 671-674.
3. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, et al. (2000) Vascular-specific growth factors and blood vessel formation. NATURE-LONDON-: 242-248.
4. McMahon G, (2000) VEGF receptor signaling in tumor angiogenesis. The Oncologist 5: 3-10.
5. Dvorak H, (2005) Angiogenesis: update 2005. Journal of Thrombosis and Haemostasis 3: 1835-1842.
6. Roberts WG, Palade GE, (1997) Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer research 57: 765.
7. Ferrara N, Gerber HP, LeCouter J, (2003) The biology of VEGF and its receptors. Nature medicine 9: 669-676.
8. Fasolo A, Sessa C (2008) mTOR inhibitors in the treatment of cancer.
9. Chen J, Fang Y, (2002) A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling. Biochemical pharmacology 64: 1071-1077.
10. LI W, TAN D, ZHANG Z, LIANG JJ, BROWN RE, (2008) Activation of Akt-mTOR-p70S6K pathway in angiogenesis in hepatocellular carcinoma. Oncology reports 20: 713-719.
11. Kuttan G, Pratheeshkumar P, Manu KA, Kuttan R, (2011) Inhibition of tumor progression by naturally occurring terpenoids. Pharmaceutical Biology 49: 995-1007.
12. Pratheeshkumar P, Sreekala C, Zhang Z, Budhraja A, Ding S, et al. (2012) Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets. Anti-cancer agents in medicinal chemistry.
13. Formica J, Regelson W, (1995) Review of the biology of quercetin and related bioflavonoids. Food and chemical toxicology 33: 1061-1080.
14. Yao H, Xu W, Shi X, Zhang Z, (2011) Dietary flavonoids as cancer prevention agents. Journal of Environmental Science and Health, Part C 29: 1-31.
15. Bischoff SC, (2008) Quercetin: potentials in the prevention and therapy of disease. Current Opinion in Clinical Nutrition & Metabolic Care 11: 733.
16. Murakami A, Ashida H, Terao J, (2008) Multitargeted cancer prevention by quercetin. Cancer letters 269: 315-325.
17. Wang S, Xu M, Li F, Wang X, Bower KA, et al. (2011) Ethanol promotes mammary tumor growth and angiogenesis: the involvement of chemoattractant factor MCP-1. Breast Cancer Research and Treatment: 1-12.
18. Pratheeshkumar P, Kuttan G, (2011) Vernolide-A, a sesquiterpene lactone from Vernonia cinerea, induces apoptosis in B16F-10 melanoma cells by modulating p53 and caspase-3 gene expressions and regulating NF-κB-mediated bcl-2 activation. Drug and Chemical Toxicology 34: 261-270.
19. Pratheeshkumar P, Kuttan G (2011) Vernolide-A inhibits tumour specific angiogenesis by regulating proinflammatory cytokines, VEGF, MMPs and TIMP. European journal of pharmacology.
20. Pratheeshkumar P, Kuttan G, (2011) Andrographolide inhibits human umbilical vein endothelial cell invasion and migration by regulating MMP-2 and MMP-9 during angiogenesis. Journal of environmental pathology, toxicology and oncology: official organ of the International Society for Environmental Toxicology and Cancer 30: 33.
21. Pratheeshkumar P, Kuttan G (2011) Nomilin inhibits tumor-specific angiogenesis by downregulating VEGF, NO and proinflammatory cytokine profile and also by inhibiting the activation of MMP-2 and MMP-9. European journal of pharmacology.
22. Yi T, Cho SG, Yi Z, Pang X, Rodriguez M, et al. (2008) Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways. Molecular cancer therapeutics 7: 1789.
23. Pang X, Yi Z, Zhang X, Sung B, Qu W, et al. (2009) Acetyl-11-Keto-β-Boswellic Acid Inhibits Prostate Tumor Growth by Suppressing Vascular Endothelial Growth Factor Receptor 2-Mediated Angiogenesis. Cancer research 69: 5893.
24. Liu LZ, Jiang Y, Carpenter RL, Jing Y, Peiper SC, et al. (2011) Role and Mechanism of Arsenic in Regulating Angiogenesis. PloS one 6: e20858.
25. Budhraja A, Gao N, Zhang Z, Son YO, Cheng S, et al. (2012) Apigenin Induces Apoptosis in Human Leukemia Cells and Exhibits Anti-Leukemic Activity In Vivo. Molecular cancer therapeutics 11: 132-142.
26. Cao Y, (2009) Positive and negative modulation of angiogenesis by VEGFR1 ligands. Science's STKE 2: re1.
27. Patan S (2004) Vasculogenesis and angiogenesis. Angiogenesis in Brain Tumors: 3-32.
28. Ferrara N, Gerber HP, (2001) The role of vascular endothelial growth factor in angiogenesis. Acta haematologica 106: 148-156.
29. Berger NA, Petzold SJ, (1985) Identification of minimal size requirements of DNA for activation of poly (ADP-ribose) polymerase. Biochemistry 24: 4352-4355.
30. Berger NA (2010) Poly (ADP-ribose) in the cellular response to DNA damage.
31. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE, Poirier GG, (1993) Specific proteolytic cleavage of poly (ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer research 53: 3976.
32. Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, et al. (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis.
33. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, et al. (1995) Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase. Cell 81: 801.
34. Bhat TA, Singh RP, (2008) Tumor angiogenesis-a potential target in cancer chemoprevention. Food and chemical toxicology 46: 1334-1345.
35. Tufan AC, Satiroglu-Tufan NL, (2005) The chick embryo chorioallantoic membrane as a model system for the study of tumor angiogenesis, invasion and development of anti-angiogenic agents. Current cancer drug targets 5: 249-266.
36. Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, et al. (1989) Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246: 1309.
37. Tie J, Desai J, (2012) Antiangiogenic therapies targeting the vascular endothelia growth factor signaling system. Critical reviews in oncogenesis 17: 51.
38. Seeliger H, Guba M, Kleespies A, Jauch KW, Bruns CJ, (2007) Role of mTOR in solid tumor systems: a therapeutical target against primary tumor growth, metastases, and angiogenesis. Cancer and Metastasis Reviews 26: 611-621.
39. Yap TA, Garrett MD, Walton MI, Raynaud F, De Bono JS, et al. (2008) Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises. Current opinion in pharmacology 8: 393-412.
40. Manning BD, Cantley LC, (2007) AKT/PKB signaling: navigating downstream. cell 129: 1261-1274.
41. Liu LZ, Zheng JZ, Wang XR, Jiang BH, (2008) Endothelial p70 S6 kinase 1 in regulating tumor angiogenesis. Cancer research 68: 8183.