-
1
-
-
4744372082
-
Evolution of the Fgf and Fgfr gene families
-
Itoh N., Ornitz D.M. Evolution of the Fgf and Fgfr gene families. Trends Genet. 2004, 20:563-569.
-
(2004)
Trends Genet.
, vol.20
, pp. 563-569
-
-
Itoh, N.1
Ornitz, D.M.2
-
4
-
-
0025001394
-
Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor
-
Flaumenhaft R., Moscatelli D., Rifkin D.B. Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor. J. Cell Biol. 1990, 111:1651-1659.
-
(1990)
J. Cell Biol.
, vol.111
, pp. 1651-1659
-
-
Flaumenhaft, R.1
Moscatelli, D.2
Rifkin, D.B.3
-
5
-
-
55249119775
-
The Klotho gene family and the endocrine fibroblast growth factors
-
Kurosu H., Kuro-o M. The Klotho gene family and the endocrine fibroblast growth factors. Curr. Opin. Nephrol. Hypertens. 2008, 17:368-372.
-
(2008)
Curr. Opin. Nephrol. Hypertens.
, vol.17
, pp. 368-372
-
-
Kurosu, H.1
Kuro-o, M.2
-
6
-
-
58349115748
-
The Klotho gene family as a regulator of endocrine fibroblast growth factors
-
Kurosu H., Kuro O.M. The Klotho gene family as a regulator of endocrine fibroblast growth factors. Mol. Cell. Endocrinol. 2009, 299:72-78.
-
(2009)
Mol. Cell. Endocrinol.
, vol.299
, pp. 72-78
-
-
Kurosu, H.1
Kuro, O.M.2
-
7
-
-
84859553676
-
Klotho and betaKlotho
-
Kuro-o M. Klotho and betaKlotho. Adv. Exp. Med. Biol. 2012, 728:25-40.
-
(2012)
Adv. Exp. Med. Biol.
, vol.728
, pp. 25-40
-
-
Kuro-o, M.1
-
8
-
-
61649100307
-
The FGF family: biology, pathophysiology and therapy
-
Beenken A., Mohammadi M. The FGF family: biology, pathophysiology and therapy. Nat. Rev. Drug Discov. 2009, 8:235-253.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 235-253
-
-
Beenken, A.1
Mohammadi, M.2
-
9
-
-
18144415072
-
Mechanisms underlying differential responses to FGF signaling
-
Dailey L., Ambrosetti D., Mansukhani A., Basilico C. Mechanisms underlying differential responses to FGF signaling. Cytokine Growth Factor Rev. 2005, 16:233-247.
-
(2005)
Cytokine Growth Factor Rev.
, vol.16
, pp. 233-247
-
-
Dailey, L.1
Ambrosetti, D.2
Mansukhani, A.3
Basilico, C.4
-
10
-
-
75149170979
-
Fibroblast growth factor signalling: from development to cancer
-
Turner N., Grose R. Fibroblast growth factor signalling: from development to cancer. Nat. Rev. Cancer 2010, 10:116-129.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 116-129
-
-
Turner, N.1
Grose, R.2
-
11
-
-
0030845817
-
Mapping of DNA amplifications at 15 chromosomal localizations in 1875 breast tumors: definition of phenotypic groups
-
Courjal F., et al. Mapping of DNA amplifications at 15 chromosomal localizations in 1875 breast tumors: definition of phenotypic groups. Cancer Res. 1997, 57:4360-4367.
-
(1997)
Cancer Res.
, vol.57
, pp. 4360-4367
-
-
Courjal, F.1
-
12
-
-
78650451788
-
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
-
62ra93
-
Weiss J., et al. Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci. Transl. Med. 2010, 2. 62ra93.
-
(2010)
Sci. Transl. Med.
, vol.2
-
-
Weiss, J.1
-
13
-
-
26444481568
-
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
-
Rand V., et al. Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:14344-14349.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 14344-14349
-
-
Rand, V.1
-
14
-
-
0032954333
-
Alterations in expression of basic fibroblast growth factor (FGF) 2 and its receptor FGFR-1 in human prostate cancer
-
Giri D., Ropiquet F., Ittmann M. Alterations in expression of basic fibroblast growth factor (FGF) 2 and its receptor FGFR-1 in human prostate cancer. Clin. Cancer Res. 1999, 5:1063-1071.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 1063-1071
-
-
Giri, D.1
Ropiquet, F.2
Ittmann, M.3
-
16
-
-
84907056979
-
Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC
-
Tchaicha J.H., et al. Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC. Cancer Res. 2014, 74:4676-4684.
-
(2014)
Cancer Res.
, vol.74
, pp. 4676-4684
-
-
Tchaicha, J.H.1
-
17
-
-
47249122523
-
Drug-sensitive FGFR2 mutations in endometrial carcinoma
-
Dutt A., et al. Drug-sensitive FGFR2 mutations in endometrial carcinoma. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:8713-8717.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 8713-8717
-
-
Dutt, A.1
-
18
-
-
58749107496
-
Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma
-
Gartside M.G., et al. Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma. Mol. Cancer Res. 2009, 7:41-54.
-
(2009)
Mol. Cancer Res.
, vol.7
, pp. 41-54
-
-
Gartside, M.G.1
-
19
-
-
84877099987
-
Tumor-specific isoform switch of the fibroblast growth factor receptor 2 underlies the mesenchymal and malignant phenotypes of clear cell renal cell carcinomas
-
Zhao Q., et al. Tumor-specific isoform switch of the fibroblast growth factor receptor 2 underlies the mesenchymal and malignant phenotypes of clear cell renal cell carcinomas. Clin. Cancer Res. 2013, 19:2460-2472.
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 2460-2472
-
-
Zhao, Q.1
-
20
-
-
42049120475
-
FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival
-
Kunii K., et al. FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival. Cancer Res. 2008, 68:2340-2348.
-
(2008)
Cancer Res.
, vol.68
, pp. 2340-2348
-
-
Kunii, K.1
-
21
-
-
40949090037
-
Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis
-
Cha J.Y., Lambert Q.T., Reuther G.W., Der C.J. Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis. Mol. Cancer Res. 2008, 6:435-445.
-
(2008)
Mol. Cancer Res.
, vol.6
, pp. 435-445
-
-
Cha, J.Y.1
Lambert, Q.T.2
Reuther, G.W.3
Der, C.J.4
-
22
-
-
34250006413
-
Genome-wide association study identifies novel breast cancer susceptibility loci
-
Easton D.F., et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 2007, 447:1087-1093.
-
(2007)
Nature
, vol.447
, pp. 1087-1093
-
-
Easton, D.F.1
-
23
-
-
43249123378
-
Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
-
Garcia-Closas M., et al. Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet. 2008, 4:e1000054.
-
(2008)
PLoS Genet.
, vol.4
, pp. e1000054
-
-
Garcia-Closas, M.1
-
24
-
-
0032841519
-
Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas
-
Cappellen D., et al. Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. Nat. Genet. 1999, 23:18-20.
-
(1999)
Nat. Genet.
, vol.23
, pp. 18-20
-
-
Cappellen, D.1
-
25
-
-
0030922231
-
Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
-
Chesi M., et al. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat. Genet. 1997, 16:260-264.
-
(1997)
Nat. Genet.
, vol.16
, pp. 260-264
-
-
Chesi, M.1
-
26
-
-
33845393660
-
FGFR3 mutations in benign skin tumors
-
Hafner C., Vogt T., Hartmann A. FGFR3 mutations in benign skin tumors. Cell Cycle 2006, 5:2723-2728.
-
(2006)
Cell Cycle
, vol.5
, pp. 2723-2728
-
-
Hafner, C.1
Vogt, T.2
Hartmann, A.3
-
28
-
-
56949101730
-
Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention
-
Ho H.K., et al. Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention. J. Hepatol. 2009, 50:118-127.
-
(2009)
J. Hepatol.
, vol.50
, pp. 118-127
-
-
Ho, H.K.1
-
29
-
-
24744451851
-
FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer
-
Spinola M., et al. FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer. Oncol. Rep. 2005, 14:415-419.
-
(2005)
Oncol. Rep.
, vol.14
, pp. 415-419
-
-
Spinola, M.1
-
30
-
-
70449450426
-
Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models
-
Taylor J.G.t., et al. Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models. J. Clin. Invest. 2009, 119:3395-3407.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3395-3407
-
-
Taylor, J.1
-
31
-
-
72249111162
-
Anti-FGF2 approaches as a strategy to compensate resistance to anti-VEGF therapy: long-pentraxin 3 as a novel antiangiogenic FGF2-antagonist
-
Alessi P., et al. Anti-FGF2 approaches as a strategy to compensate resistance to anti-VEGF therapy: long-pentraxin 3 as a novel antiangiogenic FGF2-antagonist. Eur. Cytokine Netw. 2009, 20:225-234.
-
(2009)
Eur. Cytokine Netw.
, vol.20
, pp. 225-234
-
-
Alessi, P.1
-
32
-
-
16944362446
-
Angiogenesis in ischemic heart disease
-
Ware J.A., Simons M. Angiogenesis in ischemic heart disease. Nat. Med. 1997, 3:158-164.
-
(1997)
Nat. Med.
, vol.3
, pp. 158-164
-
-
Ware, J.A.1
Simons, M.2
-
33
-
-
0026709283
-
Salvage of infarcted myocardium by angiogenic action of basic fibroblast growth factor
-
Yanagisawa-Miwa A., et al. Salvage of infarcted myocardium by angiogenic action of basic fibroblast growth factor. Science 1992, 257:1401-1403.
-
(1992)
Science
, vol.257
, pp. 1401-1403
-
-
Yanagisawa-Miwa, A.1
-
34
-
-
33746306130
-
FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2
-
Pardo O.E., et al. FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2. EMBO J. 2006, 25:3078-3088.
-
(2006)
EMBO J.
, vol.25
, pp. 3078-3088
-
-
Pardo, O.E.1
-
35
-
-
0035878998
-
Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas
-
Hanada K., Perry-Lalley D.M., Ohnmacht G.A., Bettinotti M.P., Yang J.C. Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas. Cancer Res. 2001, 61:5511-5516.
-
(2001)
Cancer Res.
, vol.61
, pp. 5511-5516
-
-
Hanada, K.1
Perry-Lalley, D.M.2
Ohnmacht, G.A.3
Bettinotti, M.P.4
Yang, J.C.5
-
36
-
-
0031702821
-
FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation
-
Hu M.C., et al. FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation. Mol. Cell. Biol. 1998, 18:6063-6074.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 6063-6074
-
-
Hu, M.C.1
-
37
-
-
0030823411
-
Basic fibroblast growth factor regulates proliferation and motility of human hepatoma cells by an autocrine mechanism
-
Kin M., et al. Basic fibroblast growth factor regulates proliferation and motility of human hepatoma cells by an autocrine mechanism. J. Hepatol. 1997, 27:677-687.
-
(1997)
J. Hepatol.
, vol.27
, pp. 677-687
-
-
Kin, M.1
-
38
-
-
18144364350
-
Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis
-
Presta M., et al. Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev. 2005, 16:159-178.
-
(2005)
Cytokine Growth Factor Rev.
, vol.16
, pp. 159-178
-
-
Presta, M.1
-
39
-
-
0036086285
-
A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice
-
Nicholes K., et al. A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice. Am. J. Pathol. 2002, 160:2295-2307.
-
(2002)
Am. J. Pathol.
, vol.160
, pp. 2295-2307
-
-
Nicholes, K.1
-
40
-
-
48549092215
-
Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling
-
Pai R., et al. Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling. Cancer Res. 2008, 68:5086-5095.
-
(2008)
Cancer Res.
, vol.68
, pp. 5086-5095
-
-
Pai, R.1
-
41
-
-
37849029159
-
Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models
-
Desnoyers L.R., et al. Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. Oncogene 2008, 27:85-97.
-
(2008)
Oncogene
, vol.27
, pp. 85-97
-
-
Desnoyers, L.R.1
-
42
-
-
79952497178
-
Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening
-
Sawey E.T., et al. Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening. Cancer Cell 2011, 19:347-358.
-
(2011)
Cancer Cell
, vol.19
, pp. 347-358
-
-
Sawey, E.T.1
-
43
-
-
58149175849
-
Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma
-
Huynh H., et al. Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin. Cancer Res. 2008, 14:6146-6153.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 6146-6153
-
-
Huynh, H.1
-
44
-
-
84922742421
-
Lenvatinib versus placebo in radioiodine-refractory thyroid cancer
-
Schlumberger M., et al. Lenvatinib versus placebo in radioiodine-refractory thyroid cancer. N. Engl. J. Med. 2015, 372:621-630.
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 621-630
-
-
Schlumberger, M.1
-
45
-
-
84924283696
-
Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib
-
Wong A.L., et al. Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib. J. Transl. Med. 2015, 13:57.
-
(2015)
J. Transl. Med.
, vol.13
, pp. 57
-
-
Wong, A.L.1
-
46
-
-
84859402751
-
Ponatinib (AP24534), a multitargeted pan-FGFR inhibitor with activity in multiple FGFR-amplified or mutated cancer models
-
Gozgit J.M., et al. Ponatinib (AP24534), a multitargeted pan-FGFR inhibitor with activity in multiple FGFR-amplified or mutated cancer models. Mol. Cancer Ther. 2012, 11:690-699.
-
(2012)
Mol. Cancer Ther.
, vol.11
, pp. 690-699
-
-
Gozgit, J.M.1
-
47
-
-
36348943566
-
Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome
-
Chase A., Grand F.H., Cross N.C. Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome. Blood 2007, 110:3729-3734.
-
(2007)
Blood
, vol.110
, pp. 3729-3734
-
-
Chase, A.1
Grand, F.H.2
Cross, N.C.3
-
48
-
-
84877679916
-
Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cells
-
Konecny G.E., et al. Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cells. Mol. Cancer Ther. 2013, 12:632-642.
-
(2013)
Mol. Cancer Ther.
, vol.12
, pp. 632-642
-
-
Konecny, G.E.1
-
49
-
-
84930542973
-
Nintedanib: A review of its use as second-line treatment in adults with advanced non-small cell lung cancer of adenocarcinoma histology
-
Dhillon S., Nintedanib: A review of its use as second-line treatment in adults with advanced non-small cell lung cancer of adenocarcinoma histology. Target Oncol. 2015.
-
(2015)
Target Oncol.
-
-
Dhillon, S.1
-
50
-
-
84946736239
-
Different effects of the BIM deletion polymorphism on treatment of solid tumors by the tyrosine kinase inhibitors (TKI) pazopanib, sunitinib, and lapatinib
-
Spraggs C.F., et al. Different effects of the BIM deletion polymorphism on treatment of solid tumors by the tyrosine kinase inhibitors (TKI) pazopanib, sunitinib, and lapatinib. Ann. Oncol. 2015.
-
(2015)
Ann. Oncol.
-
-
Spraggs, C.F.1
-
51
-
-
84930749396
-
Phase I study on the safety, pharmacokinetic profile, and efficacy of the combination of TSU-68, an oral antiangiogenic agent, and S-1 in patients with advanced hepatocellular carcinoma
-
Ikeda M., et al. Phase I study on the safety, pharmacokinetic profile, and efficacy of the combination of TSU-68, an oral antiangiogenic agent, and S-1 in patients with advanced hepatocellular carcinoma. Invest. New Drugs 2014, 32:928-936.
-
(2014)
Invest. New Drugs
, vol.32
, pp. 928-936
-
-
Ikeda, M.1
-
52
-
-
79951836740
-
Phase I safety, pharmacokinetic, and pharmacodynamic study of ENMD-2076, a novel angiogenic and Aurora kinase inhibitor, in patients with advanced solid tumors
-
Diamond J.R., et al. Phase I safety, pharmacokinetic, and pharmacodynamic study of ENMD-2076, a novel angiogenic and Aurora kinase inhibitor, in patients with advanced solid tumors. Clin. Cancer Res. 2011, 17:849-860.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 849-860
-
-
Diamond, J.R.1
-
53
-
-
79951826312
-
E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models
-
Bello E., et al. E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models. Cancer Res. 2011, 71:1396-1405.
-
(2011)
Cancer Res.
, vol.71
, pp. 1396-1405
-
-
Bello, E.1
-
54
-
-
84938690353
-
First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf-kappaBeta and p70s6k, in patients with advanced solid tumors
-
Hong D.S., et al. First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf-kappaBeta and p70s6k, in patients with advanced solid tumors. Invest. New Drugs 2014, 32:1204-1212.
-
(2014)
Invest. New Drugs
, vol.32
, pp. 1204-1212
-
-
Hong, D.S.1
-
55
-
-
0032761526
-
Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy
-
Dimitroff C.J., et al. Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy. Invest. New Drugs 1999, 17:121-135.
-
(1999)
Invest. New Drugs
, vol.17
, pp. 121-135
-
-
Dimitroff, C.J.1
-
56
-
-
84903289523
-
TC-1 overexpression promotes cell proliferation in human non-small cell lung cancer that can be inhibited by PD173074
-
Lei J., et al. TC-1 overexpression promotes cell proliferation in human non-small cell lung cancer that can be inhibited by PD173074. PLoS ONE 2014, 9:e100075.
-
(2014)
PLoS ONE
, vol.9
, pp. e100075
-
-
Lei, J.1
-
57
-
-
2342566403
-
Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074
-
Grand E.K., Chase A.J., Heath C., Rahemtulla A., Cross N.C. Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074. Leukemia 2004, 18:962-966.
-
(2004)
Leukemia
, vol.18
, pp. 962-966
-
-
Grand, E.K.1
Chase, A.J.2
Heath, C.3
Rahemtulla, A.4
Cross, N.C.5
-
58
-
-
84901804554
-
Phase II results of Dovitinib (TKI258) in patients with metastatic renal cell cancer
-
Escudier B., et al. Phase II results of Dovitinib (TKI258) in patients with metastatic renal cell cancer. Clin. Cancer Res. 2014, 20:3012-3022.
-
(2014)
Clin. Cancer Res.
, vol.20
, pp. 3012-3022
-
-
Escudier, B.1
-
59
-
-
84937032951
-
Nintedanib in non-small cell lung cancer: from preclinical to approval
-
Caglevic C., et al. Nintedanib in non-small cell lung cancer: from preclinical to approval. Ther. Adv. Respir. Dis. 2015.
-
(2015)
Ther. Adv. Respir. Dis.
-
-
Caglevic, C.1
-
60
-
-
84920741562
-
A phase II evaluation of nintedanib (BIBF-1120) in the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study
-
Dizon D.S., et al. A phase II evaluation of nintedanib (BIBF-1120) in the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study. Gynecol. Oncol. 2014, 135:441-445.
-
(2014)
Gynecol. Oncol.
, vol.135
, pp. 441-445
-
-
Dizon, D.S.1
-
61
-
-
84906278949
-
Nintedanib for the treatment of patients with advanced non-small-cell lung cancer
-
Reck M., Heigener D., Reinmuth N. Nintedanib for the treatment of patients with advanced non-small-cell lung cancer. Expert Rev. Clin. Pharmacol. 2014, 7:579-590.
-
(2014)
Expert Rev. Clin. Pharmacol.
, vol.7
, pp. 579-590
-
-
Reck, M.1
Heigener, D.2
Reinmuth, N.3
-
62
-
-
84908360684
-
Phase I clinical trial of nintedanib plus paclitaxel in early HER-2-negative breast cancer (CNIO-BR-01-2010/GEICAM-2010-10 study)
-
Quintela-Fandino M., et al. Phase I clinical trial of nintedanib plus paclitaxel in early HER-2-negative breast cancer (CNIO-BR-01-2010/GEICAM-2010-10 study). Br. J. Cancer 2014, 111:1060-1064.
-
(2014)
Br. J. Cancer
, vol.111
, pp. 1060-1064
-
-
Quintela-Fandino, M.1
-
63
-
-
84908030997
-
A phase II trial of brivanib in recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study
-
Powell M.A., et al. A phase II trial of brivanib in recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study. Gynecol. Oncol. 2014, 135:38-43.
-
(2014)
Gynecol. Oncol.
, vol.135
, pp. 38-43
-
-
Powell, M.A.1
-
64
-
-
84938744059
-
A phase 2 trial of lenvatinib (E7080) in advanced, progressive, radioiodine-refractory, differentiated thyroid cancer: A clinical outcomes and biomarker assessment
-
Cabanillas M.E., et al. A phase 2 trial of lenvatinib (E7080) in advanced, progressive, radioiodine-refractory, differentiated thyroid cancer: A clinical outcomes and biomarker assessment. Cancer 2015.
-
(2015)
Cancer
-
-
Cabanillas, M.E.1
-
65
-
-
84895057195
-
FGF receptors: cancer biology and therapeutics
-
Katoh M., Nakagama H. FGF receptors: cancer biology and therapeutics. Med. Res. Rev. 2014, 34:280-300.
-
(2014)
Med. Res. Rev.
, vol.34
, pp. 280-300
-
-
Katoh, M.1
Nakagama, H.2
-
66
-
-
84860120185
-
AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family
-
Gavine P.R., et al. AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res. 2012, 72:2045-2056.
-
(2012)
Cancer Res.
, vol.72
, pp. 2045-2056
-
-
Gavine, P.R.1
-
67
-
-
80054900437
-
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamin o]-pyrimidin-4-yl-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase
-
Guagnano V., et al. Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamin o]-pyrimidin-4-yl-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase. J. Med. Chem. 2011, 54:7066-7083.
-
(2011)
J. Med. Chem.
, vol.54
, pp. 7066-7083
-
-
Guagnano, V.1
-
68
-
-
81055124246
-
A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad spectrum of antitumor activity in several tumor xenograft models
-
Zhao G., et al. A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad spectrum of antitumor activity in several tumor xenograft models. Mol. Cancer Ther. 2011, 10:2200-2210.
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 2200-2210
-
-
Zhao, G.1
-
69
-
-
84967117073
-
TAS-120, a highly potent and selective irreversible FGFR inhibitor, is effective in tumors harboring various FGFR gene abnormalities
-
Ochiiwa H., et al. TAS-120, a highly potent and selective irreversible FGFR inhibitor, is effective in tumors harboring various FGFR gene abnormalities. Mol. Cancer Ther. 2013, 12:A270.
-
(2013)
Mol. Cancer Ther.
, vol.12
, pp. A270
-
-
Ochiiwa, H.1
-
70
-
-
84966721791
-
ARQ 087, a multi-tyrosine kinase inhibitor with potent in vitro and in vivo activity in FGFR2 driven models
-
Dransfield D., et al. ARQ 087, a multi-tyrosine kinase inhibitor with potent in vitro and in vivo activity in FGFR2 driven models. Mol. Cancer Ther. 2013, 12:A278.
-
(2013)
Mol. Cancer Ther.
, vol.12
, pp. A278
-
-
Dransfield, D.1
-
71
-
-
84925488324
-
Rationale for targeting fibroblast growth factor receptor signaling in breast cancer
-
Andre F., Cortes J. Rationale for targeting fibroblast growth factor receptor signaling in breast cancer. Breast Cancer Res. Treat. 2015, 150:1-8.
-
(2015)
Breast Cancer Res. Treat.
, vol.150
, pp. 1-8
-
-
Andre, F.1
Cortes, J.2
-
72
-
-
84939482520
-
First selective small molecule inhibitor of FGFR4 for the treatment of hepatocellular carcinomas with an activated FGFR4 signaling pathway
-
Hagel M., et al. First selective small molecule inhibitor of FGFR4 for the treatment of hepatocellular carcinomas with an activated FGFR4 signaling pathway. Cancer Discov. 2015, 5:424-437.
-
(2015)
Cancer Discov.
, vol.5
, pp. 424-437
-
-
Hagel, M.1
-
73
-
-
84877100340
-
FGFR2 gene amplification in gastric cancer predicts sensitivity to the selective FGFR inhibitor AZD4547
-
Xie L., et al. FGFR2 gene amplification in gastric cancer predicts sensitivity to the selective FGFR inhibitor AZD4547. Clin. Cancer Res. 2013, 19:2572-2583.
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 2572-2583
-
-
Xie, L.1
-
74
-
-
84895932502
-
Reductions in myeloid-derived suppressor cells and lung metastases using AZD4547 treatment of a metastatic murine breast tumor model
-
Liu L., et al. Reductions in myeloid-derived suppressor cells and lung metastases using AZD4547 treatment of a metastatic murine breast tumor model. Cell. Physiol. Biochem. 2014, 33:633-645.
-
(2014)
Cell. Physiol. Biochem.
, vol.33
, pp. 633-645
-
-
Liu, L.1
-
75
-
-
84871491773
-
FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor
-
Guagnano V., et al. FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor. Cancer Discov. 2012, 2:1118-1133.
-
(2012)
Cancer Discov.
, vol.2
, pp. 1118-1133
-
-
Guagnano, V.1
-
76
-
-
74049083220
-
Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on scirrhous gastric carcinoma
-
Yashiro M., et al. Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on scirrhous gastric carcinoma. Int. J. Cancer 2010, 126:1004-1016.
-
(2010)
Int. J. Cancer
, vol.126
, pp. 1004-1016
-
-
Yashiro, M.1
-
77
-
-
80053493427
-
Beyond VEGF: inhibition of the fibroblast growth factor pathway and antiangiogenesis
-
Lieu C., Heymach J., Overman M., Tran H., Kopetz S. Beyond VEGF: inhibition of the fibroblast growth factor pathway and antiangiogenesis. Clin. Cancer Res. 2011, 17:6130-6139.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 6130-6139
-
-
Lieu, C.1
Heymach, J.2
Overman, M.3
Tran, H.4
Kopetz, S.5
-
78
-
-
77957331045
-
GP369, an FGFR2-IIIb-specific antibody, exhibits potent antitumor activity against human cancers driven by activated FGFR2 signaling
-
Bai A., et al. GP369, an FGFR2-IIIb-specific antibody, exhibits potent antitumor activity against human cancers driven by activated FGFR2 signaling. Cancer Res. 2010, 70:7630-7639.
-
(2010)
Cancer Res.
, vol.70
, pp. 7630-7639
-
-
Bai, A.1
-
79
-
-
78650331674
-
Monoclonal antibodies to fibroblast growth factor receptor 2 effectively inhibit growth of gastric tumor xenografts
-
Zhao W.M., et al. Monoclonal antibodies to fibroblast growth factor receptor 2 effectively inhibit growth of gastric tumor xenografts. Clin. Cancer Res. 2010, 16:5750-5758.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 5750-5758
-
-
Zhao, W.M.1
-
80
-
-
66349135677
-
Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice
-
Qing J., et al. Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice. J. Clin. Invest. 2009, 119:1216-1229.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1216-1229
-
-
Qing, J.1
-
81
-
-
79960091033
-
Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4
-
Bumbaca D., et al. Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4. MAbs 2011, 3:376-386.
-
(2011)
MAbs
, vol.3
, pp. 376-386
-
-
Bumbaca, D.1
-
82
-
-
21044433871
-
A neutralizing anti-fibroblast growth factor 8 monoclonal antibody shows potent antitumor activity against androgen-dependent mouse mammary tumors in vivo
-
Shimada N., et al. A neutralizing anti-fibroblast growth factor 8 monoclonal antibody shows potent antitumor activity against androgen-dependent mouse mammary tumors in vivo. Clin. Cancer Res. 2005, 11:3897-3904.
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 3897-3904
-
-
Shimada, N.1
-
83
-
-
42949151299
-
A neutralizing anti-fibroblast growth factor (FGF) 8 monoclonal antibody shows anti-tumor activity against FGF8b-expressing LNCaP xenografts in androgen-dependent and -independent conditions
-
Maruyama-Takahashi K., et al. A neutralizing anti-fibroblast growth factor (FGF) 8 monoclonal antibody shows anti-tumor activity against FGF8b-expressing LNCaP xenografts in androgen-dependent and -independent conditions. Prostate 2008, 68:640-650.
-
(2008)
Prostate
, vol.68
, pp. 640-650
-
-
Maruyama-Takahashi, K.1
-
84
-
-
84876103735
-
Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer
-
178ra139
-
Harding T.C., et al. Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer. Sci. Transl. Med. 2013, 5. 178ra139.
-
(2013)
Sci. Transl. Med.
, vol.5
-
-
Harding, T.C.1
-
85
-
-
42549127423
-
RNA technology targeted to the WNT signaling pathway
-
Katoh M. RNA technology targeted to the WNT signaling pathway. Cancer Biol. Ther. 2008, 7:275-277.
-
(2008)
Cancer Biol. Ther.
, vol.7
, pp. 275-277
-
-
Katoh, M.1
-
86
-
-
0026448491
-
Localization of acidic fibroblast growth factor in specific subcortical neuronal populations
-
Stock A., Kuzis K., Woodward W.R., Nishi R., Eckenstein F.P. Localization of acidic fibroblast growth factor in specific subcortical neuronal populations. J. Neurosci. 1992, 12:4688-4700.
-
(1992)
J. Neurosci.
, vol.12
, pp. 4688-4700
-
-
Stock, A.1
Kuzis, K.2
Woodward, W.R.3
Nishi, R.4
Eckenstein, F.P.5
-
87
-
-
0030667241
-
Influence of IN-1 antibody and acidic FGF-fibrin glue on the response of injured corticospinal tract axons to human Schwann cell grafts
-
Guest J.D., et al. Influence of IN-1 antibody and acidic FGF-fibrin glue on the response of injured corticospinal tract axons to human Schwann cell grafts. J. Neurosci. Res. 1997, 50:888-905.
-
(1997)
J. Neurosci. Res.
, vol.50
, pp. 888-905
-
-
Guest, J.D.1
-
88
-
-
0028802448
-
Acidic fibroblast growth factor prevents death of spinal cord motoneurons in newborn rats after nerve section
-
Cuevas P., Carceller F., Gimenez-Gallego G. Acidic fibroblast growth factor prevents death of spinal cord motoneurons in newborn rats after nerve section. Neurol. Res. 1995, 17:396-399.
-
(1995)
Neurol. Res.
, vol.17
, pp. 396-399
-
-
Cuevas, P.1
Carceller, F.2
Gimenez-Gallego, G.3
-
89
-
-
23944477399
-
Spinal cord implantation with acidic fibroblast growth factor as a treatment for root avulsion in obstetric brachial plexus palsy
-
Lin P.H., Cheng H., Huang W.C., Chuang T.Y. Spinal cord implantation with acidic fibroblast growth factor as a treatment for root avulsion in obstetric brachial plexus palsy. J. Chin. Med. Assoc. 2005, 68:392-396.
-
(2005)
J. Chin. Med. Assoc.
, vol.68
, pp. 392-396
-
-
Lin, P.H.1
Cheng, H.2
Huang, W.C.3
Chuang, T.Y.4
-
90
-
-
33645736169
-
Functional recovery of chronic complete idiopathic transverse myelitis after administration of neurotrophic factors
-
Lin P.H., Chuang T.Y., Liao K.K., Cheng H., Shih Y.S. Functional recovery of chronic complete idiopathic transverse myelitis after administration of neurotrophic factors. Spinal Cord. 2006, 44:254-257.
-
(2006)
Spinal Cord.
, vol.44
, pp. 254-257
-
-
Lin, P.H.1
Chuang, T.Y.2
Liao, K.K.3
Cheng, H.4
Shih, Y.S.5
-
91
-
-
0033201853
-
Regeneration of periodontal tissues by basic fibroblast growth factor
-
Murakami S., et al. Regeneration of periodontal tissues by basic fibroblast growth factor. J. Periodontal Res. 1999, 34:425-430.
-
(1999)
J. Periodontal Res.
, vol.34
, pp. 425-430
-
-
Murakami, S.1
-
92
-
-
0035544171
-
Periodontal regeneration by FGF-2 (bFGF) in primate models
-
Takayama S., Murakami S., Shimabukuro Y., Kitamura M., Okada H. Periodontal regeneration by FGF-2 (bFGF) in primate models. J. Dent. Res. 2001, 80:2075-2079.
-
(2001)
J. Dent. Res.
, vol.80
, pp. 2075-2079
-
-
Takayama, S.1
Murakami, S.2
Shimabukuro, Y.3
Kitamura, M.4
Okada, H.5
-
93
-
-
0012654063
-
Recombinant human basic fibroblast growth factor (bFGF) stimulates periodontal regeneration in class II furcation defects created in beagle dogs
-
Murakami S., et al. Recombinant human basic fibroblast growth factor (bFGF) stimulates periodontal regeneration in class II furcation defects created in beagle dogs. J. Periodontal Res. 2003, 38:97-103.
-
(2003)
J. Periodontal Res.
, vol.38
, pp. 97-103
-
-
Murakami, S.1
-
94
-
-
49749137352
-
Periodontal tissue regeneration using fibroblast growth factor-2: randomized controlled phase II clinical trial
-
Kitamura M., et al. Periodontal tissue regeneration using fibroblast growth factor-2: randomized controlled phase II clinical trial. PLoS ONE 2008, 3:e2611.
-
(2008)
PLoS ONE
, vol.3
, pp. e2611
-
-
Kitamura, M.1
-
96
-
-
0030023110
-
Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease
-
Finch P.W., Pricolo V., Wu A., Finkelstein S.D. Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease. Gastroenterology 1996, 110:441-451.
-
(1996)
Gastroenterology
, vol.110
, pp. 441-451
-
-
Finch, P.W.1
Pricolo, V.2
Wu, A.3
Finkelstein, S.D.4
-
97
-
-
0030028984
-
Keratinocyte growth factor is required for hair development but not for wound healing
-
Guo L., Degenstein L., Fuchs E. Keratinocyte growth factor is required for hair development but not for wound healing. Genes Dev. 1996, 10:165-175.
-
(1996)
Genes Dev.
, vol.10
, pp. 165-175
-
-
Guo, L.1
Degenstein, L.2
Fuchs, E.3
-
98
-
-
0344109562
-
Keratinocyte growth factor: a unique player in epithelial repair processes
-
Werner S. Keratinocyte growth factor: a unique player in epithelial repair processes. Cytokine Growth Factor Rev. 1998, 9:153-165.
-
(1998)
Cytokine Growth Factor Rev.
, vol.9
, pp. 153-165
-
-
Werner, S.1
-
99
-
-
0033673940
-
Keratinocyte growth factor-2 (FGF-10) promotes healing of experimental small intestinal ulceration in rats
-
Han D.S., et al. Keratinocyte growth factor-2 (FGF-10) promotes healing of experimental small intestinal ulceration in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 2000, 279:G1011-G1022.
-
(2000)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.279
, pp. G1011-G1022
-
-
Han, D.S.1
-
100
-
-
0033004281
-
Efficacy of keratinocyte growth factor-2 in dextran sulfate sodium-induced murine colitis
-
Miceli R., et al. Efficacy of keratinocyte growth factor-2 in dextran sulfate sodium-induced murine colitis. J. Pharmacol. Exp. Ther. 1999, 290:464-471.
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.290
, pp. 464-471
-
-
Miceli, R.1
-
101
-
-
0038095637
-
Repifermin (keratinocyte growth factor-2) for the treatment of active ulcerative colitis: a randomized, double-blind, placebo-controlled, dose-escalation trial
-
Sandborn W.J., et al. Repifermin (keratinocyte growth factor-2) for the treatment of active ulcerative colitis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Aliment. Pharmacol. Ther. 2003, 17:1355-1364.
-
(2003)
Aliment. Pharmacol. Ther.
, vol.17
, pp. 1355-1364
-
-
Sandborn, W.J.1
-
102
-
-
11144235534
-
Phase I/II randomized trial evaluating the safety and clinical effects of repifermin administered to reduce mucositis in patients undergoing autologous hematopoietic stem cell transplantation
-
Freytes C.O., et al. Phase I/II randomized trial evaluating the safety and clinical effects of repifermin administered to reduce mucositis in patients undergoing autologous hematopoietic stem cell transplantation. Clin. Cancer Res. 2004, 10:8318-8324.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 8318-8324
-
-
Freytes, C.O.1
-
103
-
-
84902436509
-
Effect of FGF10 monoclonal antibody on psoriasis-like model in guinea pigs
-
Xia J.X., et al. Effect of FGF10 monoclonal antibody on psoriasis-like model in guinea pigs. Int. J. Clin. Exp. Pathol. 2014, 7:2219-2228.
-
(2014)
Int. J. Clin. Exp. Pathol.
, vol.7
, pp. 2219-2228
-
-
Xia, J.X.1
-
104
-
-
0036205735
-
FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis
-
Ohbayashi N., et al. FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev. 2002, 16:870-879.
-
(2002)
Genes Dev.
, vol.16
, pp. 870-879
-
-
Ohbayashi, N.1
-
105
-
-
0036246477
-
Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors
-
Ellsworth J.L., et al. Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors. Osteoarthritis Cartilage 2002, 10:308-320.
-
(2002)
Osteoarthritis Cartilage
, vol.10
, pp. 308-320
-
-
Ellsworth, J.L.1
-
106
-
-
0037151091
-
Fibroblast growth factor 18 influences proximal programming during lung morphogenesis
-
Whitsett J.A., et al. Fibroblast growth factor 18 influences proximal programming during lung morphogenesis. J. Biol. Chem. 2002, 277:22743-22749.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 22743-22749
-
-
Whitsett, J.A.1
-
107
-
-
20144378016
-
Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis
-
Davidson D., et al. Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. J. Biol. Chem. 2005, 280:20509-20515.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 20509-20515
-
-
Davidson, D.1
-
108
-
-
20944443514
-
Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis
-
Moore E.E., et al. Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. Osteoarthritis Cartilage 2005, 13:623-631.
-
(2005)
Osteoarthritis Cartilage
, vol.13
, pp. 623-631
-
-
Moore, E.E.1
-
109
-
-
84936846401
-
Delivering rhFGF-18 via a bilayer collagen membrane to enhance microfracture treatment of chondral defects in a large animal model
-
Howard D., Wardale J., Guehring M.H., Henson F. Delivering rhFGF-18 via a bilayer collagen membrane to enhance microfracture treatment of chondral defects in a large animal model. J. Orthop. Res. 2015.
-
(2015)
J. Orthop. Res.
-
-
Howard, D.1
Wardale, J.2
Guehring, M.H.3
Henson, F.4
-
110
-
-
84903455882
-
Intraarticular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial
-
Lohmander L.S., et al. Intraarticular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial. Arthritis Rheumatol. 2014, 66:1820-1831.
-
(2014)
Arthritis Rheumatol.
, vol.66
, pp. 1820-1831
-
-
Lohmander, L.S.1
-
111
-
-
0034597752
-
FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development
-
Ohuchi H., et al. FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochem. Biophys. Res. Commun. 2000, 277:643-649.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.277
, pp. 643-649
-
-
Ohuchi, H.1
-
112
-
-
0035694459
-
Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
-
Bhushan A., et al. Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development 2001, 128:5109-5117.
-
(2001)
Development
, vol.128
, pp. 5109-5117
-
-
Bhushan, A.1
-
113
-
-
0034697007
-
Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes
-
Konishi M., Mikami T., Yamasaki M., Miyake A., Itoh N. Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes. J. Biol. Chem. 2000, 275:12119-12122.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 12119-12122
-
-
Konishi, M.1
Mikami, T.2
Yamasaki, M.3
Miyake, A.4
Itoh, N.5
-
114
-
-
18344394556
-
Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity
-
Tomlinson E., et al. Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology 2002, 143:1741-1747.
-
(2002)
Endocrinology
, vol.143
, pp. 1741-1747
-
-
Tomlinson, E.1
-
115
-
-
20444435873
-
FGF-21 as a novel metabolic regulator
-
Kharitonenkov A., et al. FGF-21 as a novel metabolic regulator. J. Clin. Invest. 2005, 115:1627-1635.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 1627-1635
-
-
Kharitonenkov, A.1
-
116
-
-
2542505481
-
Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes
-
Fu L., et al. Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. Endocrinology 2004, 145:2594-2603.
-
(2004)
Endocrinology
, vol.145
, pp. 2594-2603
-
-
Fu, L.1
-
117
-
-
77956293010
-
Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19)
-
Wu X., et al. Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19). Proc. Natl. Acad. Sci. U. S. A. 2010, 107:14158-14163.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 14158-14163
-
-
Wu, X.1
-
118
-
-
33846418834
-
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
-
Kharitonenkov A., et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology 2007, 148:774-781.
-
(2007)
Endocrinology
, vol.148
, pp. 774-781
-
-
Kharitonenkov, A.1
-
119
-
-
57349098220
-
Fibroblast growth factor 21 corrects obesity in mice
-
Coskun T., et al. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology 2008, 149:6018-6027.
-
(2008)
Endocrinology
, vol.149
, pp. 6018-6027
-
-
Coskun, T.1
-
120
-
-
61649127208
-
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
-
Xu J., et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 2009, 58:250-259.
-
(2009)
Diabetes
, vol.58
, pp. 250-259
-
-
Xu, J.1
-
121
-
-
34249686631
-
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
-
Inagaki T., et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab. 2007, 5:415-425.
-
(2007)
Cell Metab.
, vol.5
, pp. 415-425
-
-
Inagaki, T.1
-
122
-
-
84865442538
-
Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys
-
Veniant M., et al. Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys. Endocrinology 2012, 153.
-
(2012)
Endocrinology
, pp. 153
-
-
Veniant, M.1
-
123
-
-
84901821975
-
FGF21-based pharmacotherapy - potential utility for metabolic disorders
-
Gimeno R.E., Moller D.E. FGF21-based pharmacotherapy - potential utility for metabolic disorders. Trends Endocrinol. Metab. 2014, 25:303-311.
-
(2014)
Trends Endocrinol. Metab.
, vol.25
, pp. 303-311
-
-
Gimeno, R.E.1
Moller, D.E.2
-
124
-
-
84897109882
-
Inventing new medicines: the FGF21 story
-
Kharitonenkov A., Adams A.C. Inventing new medicines: the FGF21 story. Mol. Metab. 2014, 3:221-229.
-
(2014)
Mol. Metab.
, vol.3
, pp. 221-229
-
-
Kharitonenkov, A.1
Adams, A.C.2
-
126
-
-
77949328590
-
FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation
-
Wu X., et al. FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation. J. Biol. Chem. 2010, 285:5165-5170.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 5165-5170
-
-
Wu, X.1
-
127
-
-
84866171951
-
Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models
-
French D.M., et al. Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models. PLoS ONE 2012, 7:e36713.
-
(2012)
PLoS ONE
, vol.7
, pp. e36713
-
-
French, D.M.1
-
128
-
-
80054696665
-
Therapeutic utilities of fibroblast growth factor 19
-
Wu X., Li Y. Therapeutic utilities of fibroblast growth factor 19. Expert Opin. Ther. Targets 2011, 15:1307-1316.
-
(2011)
Expert Opin. Ther. Targets
, vol.15
, pp. 1307-1316
-
-
Wu, X.1
Li, Y.2
-
129
-
-
84863379532
-
Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism
-
Ge H., et al. Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism. PLoS ONE 2012, 7:e33603.
-
(2012)
PLoS ONE
, vol.7
, pp. e33603
-
-
Ge, H.1
-
130
-
-
79952803104
-
FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways
-
Wu A.L., et al. FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways. PLoS ONE 2011, 6:e17868.
-
(2011)
PLoS ONE
, vol.6
, pp. e17868
-
-
Wu, A.L.1
-
131
-
-
84922726981
-
A nontumorigenic variant of FGF19 treats cholestatic liver diseases
-
247ra100
-
Luo J., et al. A nontumorigenic variant of FGF19 treats cholestatic liver diseases. Sci. Transl. Med. 2014, 6:247ra100.
-
(2014)
Sci. Transl. Med.
, vol.6
-
-
Luo, J.1
-
132
-
-
84881508008
-
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
-
Zhang Y., et al. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. Elife 2012, 1:e00065.
-
(2012)
Elife
, vol.1
, pp. e00065
-
-
Zhang, Y.1
-
133
-
-
84901496215
-
Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome
-
Zhang J., Li Y. Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome. Drug Discov. Today 2014, 19:579.
-
(2014)
Drug Discov. Today
, vol.19
, pp. 579
-
-
Zhang, J.1
Li, Y.2
-
134
-
-
84874903440
-
Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319
-
Kharitonenkov A., et al. Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319. PLoS ONE 2013, 8:e58575.
-
(2013)
PLoS ONE
, vol.8
, pp. e58575
-
-
Kharitonenkov, A.1
-
135
-
-
84879187565
-
LY2405319, an engineered FGF21 variant, improves the metabolic status of diabetic monkeys
-
Adams A.C., et al. LY2405319, an engineered FGF21 variant, improves the metabolic status of diabetic monkeys. PLoS ONE 2013, 8:e65763.
-
(2013)
PLoS ONE
, vol.8
, pp. e65763
-
-
Adams, A.C.1
-
136
-
-
84883481988
-
The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
-
Gaich G., et al. The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. Cell Metab. 2013, 18:333-340.
-
(2013)
Cell Metab.
, vol.18
, pp. 333-340
-
-
Gaich, G.1
-
137
-
-
79958126904
-
A better anti-diabetic recombinant human fibroblast growth factor 21 (rhFGF21) modified with polyethylene glycol
-
Huang Z., et al. A better anti-diabetic recombinant human fibroblast growth factor 21 (rhFGF21) modified with polyethylene glycol. PLoS ONE 2011, 6:e20669.
-
(2011)
PLoS ONE
, vol.6
, pp. e20669
-
-
Huang, Z.1
-
138
-
-
84863011453
-
FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents
-
Mu J., et al. FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents. Diabetes 2012.
-
(2012)
Diabetes
-
-
Mu, J.1
-
139
-
-
84879389894
-
Polyethylene glycol modified FGF21 engineered to maximize potency and minimize vacuole formation
-
Xu J., et al. Polyethylene glycol modified FGF21 engineered to maximize potency and minimize vacuole formation. Bioconjug. Chem. 2013, 10.1021/bc300603k.
-
(2013)
Bioconjug. Chem.
-
-
Xu, J.1
-
140
-
-
84870278211
-
Rationale-based engineering of a potent long-acting FGF21 analog for the treatment of type 2 diabetes
-
Hecht R., et al. Rationale-based engineering of a potent long-acting FGF21 analog for the treatment of type 2 diabetes. PLoS ONE 2012, 7:e49345.
-
(2012)
PLoS ONE
, vol.7
, pp. e49345
-
-
Hecht, R.1
-
141
-
-
84880426480
-
Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody
-
Huang J., et al. Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody. J. Pharmacol. Exp. Ther. 2013, 346:270-280.
-
(2013)
J. Pharmacol. Exp. Ther.
, vol.346
, pp. 270-280
-
-
Huang, J.1
-
142
-
-
83655165300
-
Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1
-
113ra126
-
Wu A.L., et al. Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Sci. Transl. Med. 2011, 3. 113ra126.
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Wu, A.L.1
-
143
-
-
84870359606
-
Treating diabetes and obesity with an FGF21-mimetic antibody activating the betaKlotho/FGFR1c receptor complex
-
162ra153
-
Foltz I.N., et al. Treating diabetes and obesity with an FGF21-mimetic antibody activating the betaKlotho/FGFR1c receptor complex. Sci. Transl. Med. 2012, 4. 162ra153.
-
(2012)
Sci. Transl. Med.
, vol.4
-
-
Foltz, I.N.1
-
144
-
-
84865741904
-
BetaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism
-
Ding X., et al. betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab. 2012, 16:387-393.
-
(2012)
Cell Metab.
, vol.16
, pp. 387-393
-
-
Ding, X.1
-
145
-
-
84870272334
-
FGF21 requires betaklotho to act in vivo
-
Adams A.C., Cheng C.C., Coskun T., Kharitonenkov A. FGF21 requires betaklotho to act in vivo. PLoS ONE 2012, 7:e49977.
-
(2012)
PLoS ONE
, vol.7
, pp. e49977
-
-
Adams, A.C.1
Cheng, C.C.2
Coskun, T.3
Kharitonenkov, A.4
-
146
-
-
84905679771
-
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
-
Adams A.C., et al. The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue. Mol. Metab. 2013, 2:31.
-
(2013)
Mol. Metab.
, vol.2
, pp. 31
-
-
Adams, A.C.1
-
147
-
-
84876452595
-
FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/beta-klotho bispecific protein
-
Smith R., et al. FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/beta-klotho bispecific protein. PLoS ONE 2013, 8:e61432.
-
(2013)
PLoS ONE
, vol.8
, pp. e61432
-
-
Smith, R.1
-
148
-
-
84861047531
-
A PPARgamma-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
-
Jonker J.W., et al. A PPARgamma-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature 2012, 485:391-394.
-
(2012)
Nature
, vol.485
, pp. 391-394
-
-
Jonker, J.W.1
-
149
-
-
84906826372
-
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
-
Suh J.M., et al. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature 2014, 513:436-439.
-
(2014)
Nature
, vol.513
, pp. 436-439
-
-
Suh, J.M.1
-
150
-
-
84865258676
-
Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor
-
Goetz R., et al. Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor. J. Biol. Chem. 2012, 287:29134-29146.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 29134-29146
-
-
Goetz, R.1
-
151
-
-
45649085226
-
Inhibition of growth hormone signaling by the fasting-induced hormone FGF21
-
Inagaki T., et al. Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metab. 2008, 8:77-83.
-
(2008)
Cell Metab.
, vol.8
, pp. 77-83
-
-
Inagaki, T.1
-
152
-
-
84864388774
-
Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate
-
Wu S., Levenson A., Kharitonenkov A., De Luca F. Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate. J. Biol. Chem. 2012, 287:26060-26067.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 26060-26067
-
-
Wu, S.1
Levenson, A.2
Kharitonenkov, A.3
De Luca, F.4
-
153
-
-
84863116228
-
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma
-
Wei W., et al. Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma. Proc. Natl. Acad. Sci. U. S. A. 2012.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
-
-
Wei, W.1
-
154
-
-
84883778996
-
FGF21 regulates metabolism and circadian behavior by acting on the nervous system
-
Bookout A.L., et al. FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat. Med. 2013, 19:1147-1152.
-
(2013)
Nat. Med.
, vol.19
, pp. 1147-1152
-
-
Bookout, A.L.1
-
155
-
-
84863012459
-
Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones
-
Dutchak P.A., et al. Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones. Cell 2012, 148:556-567.
-
(2012)
Cell
, vol.148
, pp. 556-567
-
-
Dutchak, P.A.1
-
156
-
-
84883763046
-
FGF21 contributes to neuroendocrine control of female reproduction
-
Owen B.M., et al. FGF21 contributes to neuroendocrine control of female reproduction. Nat. Med. 2013, 19:1153-1156.
-
(2013)
Nat. Med.
, vol.19
, pp. 1153-1156
-
-
Owen, B.M.1
-
157
-
-
70149120326
-
Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice
-
Wu X., et al. Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:14379-14384.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 14379-14384
-
-
Wu, X.1
-
158
-
-
34948821192
-
FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver
-
Huang X., et al. FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. Diabetes 2007, 56:2501-2510.
-
(2007)
Diabetes
, vol.56
, pp. 2501-2510
-
-
Huang, X.1
-
159
-
-
84910077652
-
Fibroblast growth factor receptor 4 (FGFR4) deficiency improves insulin resistance and glucose metabolism under diet-induced obesity conditions
-
Ge H., et al. Fibroblast growth factor receptor 4 (FGFR4) deficiency improves insulin resistance and glucose metabolism under diet-induced obesity conditions. J. Biol. Chem. 2014, 289:30470-30480.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 30470-30480
-
-
Ge, H.1
-
160
-
-
48749113401
-
Targeting bile-acid signalling for metabolic diseases
-
Thomas C., Pellicciari R., Pruzanski M., Auwerx J., Schoonjans K. Targeting bile-acid signalling for metabolic diseases. Nat. Rev. Drug Discov. 2008, 7:678-693.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 678-693
-
-
Thomas, C.1
Pellicciari, R.2
Pruzanski, M.3
Auwerx, J.4
Schoonjans, K.5
-
161
-
-
84880832459
-
Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice
-
Yu X.X., et al. Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice. PLoS ONE 2013, 8:e66923.
-
(2013)
PLoS ONE
, vol.8
, pp. e66923
-
-
Yu, X.X.1
-
162
-
-
84891710536
-
Bile acid metabolism and signaling
-
Chiang J.Y. Bile acid metabolism and signaling. Compr. Physiol. 2013, 3:1191-1212.
-
(2013)
Compr. Physiol.
, vol.3
, pp. 1191-1212
-
-
Chiang, J.Y.1
-
163
-
-
33748950271
-
FXR, a multipurpose nuclear receptor
-
Lee F.Y., Lee H., Hubbert M.L., Edwards P.A., Zhang Y. FXR, a multipurpose nuclear receptor. Trends Biochem. Sci. 2006, 31:572-580.
-
(2006)
Trends Biochem. Sci.
, vol.31
, pp. 572-580
-
-
Lee, F.Y.1
Lee, H.2
Hubbert, M.L.3
Edwards, P.A.4
Zhang, Y.5
-
164
-
-
77951942185
-
FXR an emerging therapeutic target for the treatment of atherosclerosis
-
Mencarelli A., Fiorucci S. FXR an emerging therapeutic target for the treatment of atherosclerosis. J. Cell. Mol. Med. 2010, 14:79-92.
-
(2010)
J. Cell. Mol. Med.
, vol.14
, pp. 79-92
-
-
Mencarelli, A.1
Fiorucci, S.2
-
165
-
-
84859528536
-
Physiology of FGF15/19
-
Jones S.A. Physiology of FGF15/19. Adv. Exp. Med. Biol. 2012, 728:171-182.
-
(2012)
Adv. Exp. Med. Biol.
, vol.728
, pp. 171-182
-
-
Jones, S.A.1
-
166
-
-
84870568785
-
Circulating fibroblast growth factors as metabolic regulators - a critical appraisal
-
Angelin B., Larsson T.E., Rudling M. Circulating fibroblast growth factors as metabolic regulators - a critical appraisal. Cell Metab. 2012, 16:693-705.
-
(2012)
Cell Metab.
, vol.16
, pp. 693-705
-
-
Angelin, B.1
Larsson, T.E.2
Rudling, M.3
-
167
-
-
84903814274
-
Bile acid diarrhoea and FGF19: new views on diagnosis, pathogenesis and therapy
-
Walters J.R. Bile acid diarrhoea and FGF19: new views on diagnosis, pathogenesis and therapy. Nat. Rev. Gastroenterol. Hepatol. 2014, 11:426-434.
-
(2014)
Nat. Rev. Gastroenterol. Hepatol.
, vol.11
, pp. 426-434
-
-
Walters, J.R.1
-
168
-
-
33750698614
-
Identification of a hormonal basis for gallbladder filling
-
Choi M., et al. Identification of a hormonal basis for gallbladder filling. Nat. Med. 2006, 12:1253-1255.
-
(2006)
Nat. Med.
, vol.12
, pp. 1253-1255
-
-
Choi, M.1
-
169
-
-
84856407211
-
The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract
-
Zweers S.J., et al. The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract. Hepatology 2012, 55:575-583.
-
(2012)
Hepatology
, vol.55
, pp. 575-583
-
-
Zweers, S.J.1
-
170
-
-
84893697885
-
Cynomolgus monkey gallbladder bile contains high concentrations of fibroblast growth factor 19
-
Luo L., Luo F., Wang T. Cynomolgus monkey gallbladder bile contains high concentrations of fibroblast growth factor 19. Hepatology 2014, 59:732-733.
-
(2014)
Hepatology
, vol.59
, pp. 732-733
-
-
Luo, L.1
Luo, F.2
Wang, T.3
-
171
-
-
0037663483
-
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis
-
Holt J.A., et al. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev. 2003, 17:1581-1591.
-
(2003)
Genes Dev.
, vol.17
, pp. 1581-1591
-
-
Holt, J.A.1
-
172
-
-
58949097425
-
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression
-
Song K.H., Li T., Owsley E., Strom S., Chiang J.Y. Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. Hepatology 2009, 49:297-305.
-
(2009)
Hepatology
, vol.49
, pp. 297-305
-
-
Song, K.H.1
Li, T.2
Owsley, E.3
Strom, S.4
Chiang, J.Y.5
-
173
-
-
65449177586
-
High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis
-
Schaap F.G., van der Gaag N.A., Gouma D.J., Jansen P.L. High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis. Hepatology 2009, 49:1228-1235.
-
(2009)
Hepatology
, vol.49
, pp. 1228-1235
-
-
Schaap, F.G.1
van der Gaag, N.A.2
Gouma, D.J.3
Jansen, P.L.4
-
174
-
-
84859097478
-
Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys
-
Pai R., et al. Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys. Toxicol. Sci. 2012, 126:446-456.
-
(2012)
Toxicol. Sci.
, vol.126
, pp. 446-456
-
-
Pai, R.1
-
175
-
-
64549113761
-
New concepts in pathogenesis of renal hypophosphatemic syndromes
-
Rastegar A. New concepts in pathogenesis of renal hypophosphatemic syndromes. Iran. J. Kidney Dis. 2009, 3:1-6.
-
(2009)
Iran. J. Kidney Dis.
, vol.3
, pp. 1-6
-
-
Rastegar, A.1
-
176
-
-
25444528711
-
Hypophosphatemia: an update on its etiology and treatment
-
Gaasbeek A., Meinders A.E. Hypophosphatemia: an update on its etiology and treatment. Am. J. Med. 2005, 118:1094-1101.
-
(2005)
Am. J. Med.
, vol.118
, pp. 1094-1101
-
-
Gaasbeek, A.1
Meinders, A.E.2
-
177
-
-
84859536721
-
Evidence for FGF23 involvement in a bone-kidney axis regulating bone mineralization and systemic phosphate and vitamin D homeostasis
-
Martin A., Quarles L.D. Evidence for FGF23 involvement in a bone-kidney axis regulating bone mineralization and systemic phosphate and vitamin D homeostasis. Adv. Exp. Med. Biol. 2012, 728:65-83.
-
(2012)
Adv. Exp. Med. Biol.
, vol.728
, pp. 65-83
-
-
Martin, A.1
Quarles, L.D.2
-
178
-
-
84859554313
-
FGF23, klotho and vitamin D interactions: What have we learned from in vivo mouse genetics studies?
-
Razzaque M.S. FGF23, klotho and vitamin D interactions: What have we learned from in vivo mouse genetics studies?. Adv. Exp. Med. Biol. 2012, 728:84-91.
-
(2012)
Adv. Exp. Med. Biol.
, vol.728
, pp. 84-91
-
-
Razzaque, M.S.1
-
180
-
-
2142746439
-
FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis
-
Shimada T., et al. FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J. Bone Miner. Res. 2004, 19:429-435.
-
(2004)
J. Bone Miner. Res.
, vol.19
, pp. 429-435
-
-
Shimada, T.1
-
181
-
-
40949147446
-
Physiological regulation and disorders of phosphate metabolism - pivotal role of fibroblast growth factor 23
-
Fukumoto S. Physiological regulation and disorders of phosphate metabolism - pivotal role of fibroblast growth factor 23. Intern. Med. 2008, 47:337-343.
-
(2008)
Intern. Med.
, vol.47
, pp. 337-343
-
-
Fukumoto, S.1
-
182
-
-
33646367420
-
Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D
-
Liu S., et al. Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. J. Am. Soc. Nephrol. 2006, 17:1305-1315.
-
(2006)
J. Am. Soc. Nephrol.
, vol.17
, pp. 1305-1315
-
-
Liu, S.1
-
183
-
-
36849017126
-
The parathyroid is a target organ for FGF23 in rats
-
Ben-Dov I.Z., et al. The parathyroid is a target organ for FGF23 in rats. J. Clin. Invest. 2007, 117:4003-4008.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 4003-4008
-
-
Ben-Dov, I.Z.1
-
184
-
-
35848947037
-
Fibroblast growth factor-23 regulates parathyroid hormone and 1alpha-hydroxylase expression in cultured bovine parathyroid cells
-
Krajisnik T., et al. Fibroblast growth factor-23 regulates parathyroid hormone and 1alpha-hydroxylase expression in cultured bovine parathyroid cells. J. Endocrinol. 2007, 195:125-131.
-
(2007)
J. Endocrinol.
, vol.195
, pp. 125-131
-
-
Krajisnik, T.1
-
185
-
-
0030724491
-
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
-
Kuro-o M., et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997, 390:45-51.
-
(1997)
Nature
, vol.390
, pp. 45-51
-
-
Kuro-o, M.1
-
186
-
-
1642416884
-
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism
-
Shimada T., et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J. Clin. Invest. 2004, 113:561-568.
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 561-568
-
-
Shimada, T.1
-
187
-
-
9644303231
-
Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice
-
Sitara D., et al. Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 2004, 23:421-432.
-
(2004)
Matrix Biol.
, vol.23
, pp. 421-432
-
-
Sitara, D.1
-
188
-
-
0033763097
-
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
-
Consortium A. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat. Genet. 2000, 26:345-348.
-
(2000)
Nat. Genet.
, vol.26
, pp. 345-348
-
-
Consortium, A.1
-
189
-
-
14344279878
-
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
-
Shimada T., et al. Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:6500-6505.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 6500-6505
-
-
Shimada, T.1
-
190
-
-
20244368616
-
Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia
-
Jonsson K.B., et al. Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. N. Engl. J. Med. 2003, 348:1656-1663.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1656-1663
-
-
Jonsson, K.B.1
-
191
-
-
16344378643
-
Elevated fibroblast growth factor-23 in hypophosphatemic linear nevus sebaceous syndrome
-
Hoffman W.H., Jueppner H.W., Deyoung B.R., O'Dorisio M.S., Given K.S. Elevated fibroblast growth factor-23 in hypophosphatemic linear nevus sebaceous syndrome. Am. J. Med. Genet. A 2005, 134:233-236.
-
(2005)
Am. J. Med. Genet. A
, vol.134
, pp. 233-236
-
-
Hoffman, W.H.1
Jueppner, H.W.2
Deyoung, B.R.3
O'Dorisio, M.S.4
Given, K.S.5
-
192
-
-
33644869881
-
Extended mutational analyses of FGFR1 in osteoglophonic dysplasia
-
Farrow E.G., et al. Extended mutational analyses of FGFR1 in osteoglophonic dysplasia. Am. J. Med. Genet. A 2006, 140:537-539.
-
(2006)
Am. J. Med. Genet. A
, vol.140
, pp. 537-539
-
-
Farrow, E.G.1
-
193
-
-
85047691059
-
FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting
-
Riminucci M., et al. FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting. J. Clin. Invest. 2003, 112:683-692.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 683-692
-
-
Riminucci, M.1
-
194
-
-
50249114540
-
Anti-FGF23 neutralizing antibodies show the physiological role and structural features of FGF23
-
Yamazaki Y., et al. Anti-FGF23 neutralizing antibodies show the physiological role and structural features of FGF23. J. Bone Miner. Res. 2008, 23:1509-1518.
-
(2008)
J. Bone Miner. Res.
, vol.23
, pp. 1509-1518
-
-
Yamazaki, Y.1
-
195
-
-
73949119246
-
Therapeutic effects of anti-FGF23 antibodies in hypophosphatemic rickets/osteomalacia
-
Aono Y., et al. Therapeutic effects of anti-FGF23 antibodies in hypophosphatemic rickets/osteomalacia. J. Bone Miner. Res. 2009, 24:1879-1888.
-
(2009)
J. Bone Miner. Res.
, vol.24
, pp. 1879-1888
-
-
Aono, Y.1
-
196
-
-
84897560527
-
Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia
-
Carpenter T.O., et al. Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia. J. Clin. Invest. 2014, 124:1587-1597.
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 1587-1597
-
-
Carpenter, T.O.1
-
197
-
-
76249084836
-
Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation
-
Goetz R., et al. Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:407-412.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 407-412
-
-
Goetz, R.1
-
198
-
-
33749508711
-
Post-transplant hypophosphatemia: tertiary 'hyper-phosphatoninism'?
-
Bhan I., et al. Post-transplant hypophosphatemia: tertiary 'hyper-phosphatoninism'?. Kidney Int. 2006, 70:1486-1494.
-
(2006)
Kidney Int.
, vol.70
, pp. 1486-1494
-
-
Bhan, I.1
-
199
-
-
0027228516
-
Familial tumoral calcinosis. A clinical, histopathologic, and ultrastructural study with an analysis of its calcifying process and pathogenesis
-
Slavin R.E., Wen J., Kumar D., Evans E.B. Familial tumoral calcinosis. A clinical, histopathologic, and ultrastructural study with an analysis of its calcifying process and pathogenesis. Am. J. Surg. Pathol. 1993, 17:788-802.
-
(1993)
Am. J. Surg. Pathol.
, vol.17
, pp. 788-802
-
-
Slavin, R.E.1
Wen, J.2
Kumar, D.3
Evans, E.B.4
-
200
-
-
2642546399
-
Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis
-
Topaz O., et al. Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis. Nat. Genet. 2004, 36:579-581.
-
(2004)
Nat. Genet.
, vol.36
, pp. 579-581
-
-
Topaz, O.1
-
201
-
-
13544270218
-
An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia
-
Benet-Pages A., Orlik P., Strom T.M., Lorenz-Depiereux B. An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum. Mol. Genet. 2005, 14:385-390.
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 385-390
-
-
Benet-Pages, A.1
Orlik, P.2
Strom, T.M.3
Lorenz-Depiereux, B.4
-
202
-
-
34848871595
-
A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis
-
Ichikawa S., et al. A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. J. Clin. Invest. 2007, 117:2684-2691.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2684-2691
-
-
Ichikawa, S.1
-
203
-
-
84874338054
-
Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia
-
Wu A.L., et al. Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia. PLoS ONE 2013, 8:e57322.
-
(2013)
PLoS ONE
, vol.8
, pp. e57322
-
-
Wu, A.L.1
-
204
-
-
75749129364
-
FGF23-parathyroid interaction: implications in chronic kidney disease
-
Komaba H., Fukagawa M. FGF23-parathyroid interaction: implications in chronic kidney disease. Kidney Int. 2010, 77:292-298.
-
(2010)
Kidney Int.
, vol.77
, pp. 292-298
-
-
Komaba, H.1
Fukagawa, M.2
-
205
-
-
70350348267
-
The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis
-
Razzaque M.S. The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis. Nat. Rev. Endocrinol. 2009, 5:611-619.
-
(2009)
Nat. Rev. Endocrinol.
, vol.5
, pp. 611-619
-
-
Razzaque, M.S.1
-
206
-
-
84859536160
-
FGF23 in chronic kidney disease
-
Wahl P., Wolf M. FGF23 in chronic kidney disease. Adv. Exp. Med. Biol. 2012, 728:107-125.
-
(2012)
Adv. Exp. Med. Biol.
, vol.728
, pp. 107-125
-
-
Wahl, P.1
Wolf, M.2
-
207
-
-
49249104701
-
Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
-
Gutierrez O.M., et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N. Engl. J. Med. 2008, 359:584-592.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 584-592
-
-
Gutierrez, O.M.1
-
208
-
-
79957870135
-
Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease
-
Isakova T., et al. Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int. 2011, 79:1370-1378.
-
(2011)
Kidney Int.
, vol.79
, pp. 1370-1378
-
-
Isakova, T.1
-
209
-
-
76149101238
-
Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active
-
Shimada T., et al. Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active. J. Clin. Endocrinol. Metab. 2010, 95:578-585.
-
(2010)
J. Clin. Endocrinol. Metab.
, vol.95
, pp. 578-585
-
-
Shimada, T.1
-
210
-
-
80555148939
-
FGF23 induces left ventricular hypertrophy
-
Faul C., et al. FGF23 induces left ventricular hypertrophy. J. Clin. Invest. 2011, 121:4393-4408.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 4393-4408
-
-
Faul, C.1
-
211
-
-
84884536419
-
Pathophysiological roles of FGF signaling in the heart
-
Itoh N., Ohta H. Pathophysiological roles of FGF signaling in the heart. Front. Physiol. 2013, 4:247.
-
(2013)
Front. Physiol.
, vol.4
, pp. 247
-
-
Itoh, N.1
Ohta, H.2
-
212
-
-
18344417427
-
Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris
-
Unger E.F., et al. Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris. Am. J. Cardiol. 2000, 85:1414-1419.
-
(2000)
Am. J. Cardiol.
, vol.85
, pp. 1414-1419
-
-
Unger, E.F.1
-
213
-
-
0036658287
-
Long-term effects of surgical angiogenic therapy with fibroblast growth factor 2 protein
-
Ruel M., et al. Long-term effects of surgical angiogenic therapy with fibroblast growth factor 2 protein. J. Thorac. Cardiovasc. Surg. 2002, 124:28-34.
-
(2002)
J. Thorac. Cardiovasc. Surg.
, vol.124
, pp. 28-34
-
-
Ruel, M.1
-
214
-
-
0027471478
-
Suramin, an active drug for prostate cancer: interim observations in a phase I trial
-
Eisenberger M.A., et al. Suramin, an active drug for prostate cancer: interim observations in a phase I trial. J. Natl. Cancer Inst. 1993, 85:611-621.
-
(1993)
J. Natl. Cancer Inst.
, vol.85
, pp. 611-621
-
-
Eisenberger, M.A.1
-
215
-
-
7644240078
-
Quality of life impact of three different doses of suramin in patients with metastatic hormone-refractory prostate carcinoma: results of Intergroup O159/Cancer and Leukemia Group B 9480
-
Ahles T.A., et al. Quality of life impact of three different doses of suramin in patients with metastatic hormone-refractory prostate carcinoma: results of Intergroup O159/Cancer and Leukemia Group B 9480. Cancer 2004, 101:2202-2208.
-
(2004)
Cancer
, vol.101
, pp. 2202-2208
-
-
Ahles, T.A.1
-
216
-
-
10344242939
-
Palifermin for oral mucositis after intensive therapy for hematologic cancers
-
Spielberger R., et al. Palifermin for oral mucositis after intensive therapy for hematologic cancers. N. Engl. J. Med. 2004, 351:2590-2598.
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 2590-2598
-
-
Spielberger, R.1
-
217
-
-
84885484874
-
Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice
-
Camacho R.C., Zafian P.T., Achanfuo-Yeboah J., Manibusan A., Berger J.P. Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice. Eur. J. Pharmacol. 2013, 715:41-45.
-
(2013)
Eur. J. Pharmacol.
, vol.715
, pp. 41-45
-
-
Camacho, R.C.1
Zafian, P.T.2
Achanfuo-Yeboah, J.3
Manibusan, A.4
Berger, J.P.5
|