Vascular endothelial-cadherin and vascular stability

Current Opinion in Hematology

Volumn 19, Issue 3, 2012, Pages 218-223

  Dejana, Elisabetta ^a,b   Giampietro, Costanza ^a  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

adherens junctions; adhesion molecules; angiogenesis; permeability

Indexed keywords

BETA CATENIN; CLAUDIN 5; TRANSCRIPTION FACTOR FKHR; VASCULAR ENDOTHELIAL CADHERIN;

ANGIOGENESIS; APOPTOSIS; BLEEDING; CELL ADHESION; CELL DIFFERENTIATION; CELL GROWTH; CELL JUNCTION; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; ENDOTHELIUM CELL; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; REVIEW; SIGNAL TRANSDUCTION; TIGHT JUNCTION; VASCULAR DISEASE; VASCULAR RESISTANCE; VASCULARIZATION;

ADHERENS JUNCTIONS; CADHERINS; CAPILLARY PERMEABILITY; ENDOTHELIUM, VASCULAR; HUMANS;

EID: 84859854623     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e3283523e1c     Document Type: Review

References (42)

1. Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov 2011; 10:417-427.
2. Dejana E, Tournier-Lasserve E, Weinstein BM. The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications. Dev Cell 2009; 16:209-221.
3. Vestweber D, Winderlich M, Cagna G, Nottebaum AF. Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player. Trends Cell Biol 2009; 19:8-15.
4. Le Guelte A, Dwyer J, Gavard J. Jumping the barrier: VE-cadherin, VEGF and other angiogenic modifiers in cancer. Biol Cell 2011; 103:593-605.
5. Bazzoni G, Dejana E. Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev 2004; 84:869-901. (Pubitemid 38823769)
6. Vestweber D. VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol 2008; 28:223-232. (Pubitemid 351161193)
7. Gonzalez-Mariscal L, Tapia R, Chamorro D. Crosstalk of tight junction components with signaling pathways. Biochim Biophys Acta 2008; 1778: 729-756. (Pubitemid 351317800)
8. Giampietro C, Taddei A, CoradaM, et al. Overlapping and divergent signalling pathways of N-and VE-cadherin in endothelial cells. Blood 2012. doi:10.1182/blood-2011-09-381012. [Epub ahead of print]
9. Kooistra MR, Dube N, Bos JL. Rap1: a key regulator in cell-cell junction formation. J Cell Sci 2007; 120:17-22. (Pubitemid 46206645)
10. Ridley AJ. Historical overview of Rho GTPases. Methods Mol Biol 2012; 827:3-12.
11. Kronstein R, Seebach J, Grossklaus S, et al. Caveolin-1 opens endothelial cell junctions by targeting catenins. Cardiovasc Res 2012; 93:130-140.
12. Glading A, Han J, Stockton RA, Ginsberg MH. KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. J Cell Biol 2007; 179:247-254. (Pubitemid 350004889)
13. Lampugnani MG,Orsenigo F, Rudini N, et al. CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci 2010; 123:1073-1080.
14. Huang RL, Teo Z, Chong HC, et al. ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters. Blood 2011; 118:3990-4002.
15. Balda MS, Matter K. Tight junctions and the regulation of gene expression. Biochim Biophys Acta 2009; 1788:761-767.
16. Nusrat A, Turner JR, Madara JL. Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am J PhysiolGastrointest Liver Physiol 2000; 279:G851-G857.
17. Nitta T, Hata M, Gotoh S, et al. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol 2003; 161:653-660. (Pubitemid 36578587)
18. Weber C, Fraemohs L, Dejana E. The role of junctional adhesion molecules in vascular inflammation. Nat Rev Immunol 2007; 7:467-477. (Pubitemid 46834851)
19. Takai Y, Miyoshi J, Ikeda W, Ogita H. Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation. Nat Rev Mol Cell Biol 2008; 9:603-615. (Pubitemid 352032927)
20. Taddei A, Giampietro C, Conti A, et al. Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5. Nat Cell Biol 2008; 10:923-934.
21. Burgering BM, Kops GJ. Cell cycle and death control: long live Forkheads. Trends Biochem Sci 2002; 27:352-360. (Pubitemid 34756518)
22. Lampugnani MG, Orsenigo F, Gagliani MC, et al. Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol 2006; 174:593-604. (Pubitemid 44231870)
23. Rudini N, Felici A, Giampietro C, et al. VE-cadherin is a critical endothelial regulator of TGF-beta signalling. EMBO J 2008; 27:993-1004. (Pubitemid 351508155)
24. Hou WH, Liu IH, Tsai CC, et al. CRSBP-1/LYVE-1 ligands disrupt lymphatic intercellular adhesion by inducing tyrosine phosphorylation and internalization of VE-cadherin. J Cell Sci 2011; 124:1231-1244.
25. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006; 127:469-480.
26. Liebner S, Czupalla CJ, Wolburg H. Current concepts of blood-brain barrier development. Int J Dev Biol 2011; 55:467-476.
27. Dejana E. The role of wnt signaling in physiological and pathological angiogenesis. Circ Res 2010; 107:943-952.
28. Martin-Belmonte F, Mostov K. Regulation of cell polarity during epithelial morphogenesis. Curr Opin Cell Biol 2008; 20:227-234.
29. Jaffe AB, Kaji N, Durgan J, Hall A. Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis. J Cell Biol 2008; 183:625-633.
30. Goldstein B, Macara IG. The PAR proteins: fundamental players in animal cell polarization. Dev Cell 2007; 13:609-622. (Pubitemid 350011991)
31. Oas RG, Xiao K, Summers S, et al. p120-Catenin is required for mouse vascular development. Circ Res 2010; 106:941-951.
32. Nyqvist D, Giampietro C, Dejana E. Deciphering the functional role of endothelial junctions by using in vivo models. EMBO Rep 2008; 9:742-747.
33. Mazzone M, Dettori D, Leite de Oliveira R, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 2009; 136:839-851.
34. Gavard J. Breaking the VE-cadherin bonds. FEBS Lett 2009; 583: 1-6.
35. Broermann A, Winderlich M, Block H, et al. Dissociation of VE-PTP from VEcadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo. J Exp Med 2011; 208:2393-2401.
36. Brouillard P, Vikkula M. Genetic causes of vascular malformations. Hum Mol Genet 2007; 16 (Spec No 2):R140-149.
37. Labauge P, Denier C, Bergametti F, Tournier-Lasserve E. Genetics of cavernous angiomas. Lancet Neurol 2007; 6:237-244. (Pubitemid 46228079)
38. McDonald DA, Shenkar R, Shi C, et al. A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Hum Mol Genet 2011; 20:211-222.
39. Li DY, Whitehead KJ. Evaluating strategies for the treatment of cerebral cavernous malformations. Stroke 2010; 41:S92-S94.
40. Glading AJ, Ginsberg MH. Rap1 and its effector KRIT1/CCM1 regulate betacatenin signaling. Dis Model Mech 2010; 3:73-83.
41. Boulday G, Rudini N, Maddaluno L, et al. Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice. J Exp Med 2011; 208:1835-1847.
42. Wustehube J, Bartol A, Liebler SS, et al. Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling. Proc Natl Acad Sci USA 2010; 107:12640-12645.