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Volumn 21, Issue 11, 2016, Pages

Current advances of tubulin inhibitors in nanoparticle drug delivery and vascular disruption/angiogenesis

Author keywords

Angiogenesis; Antimitotic; Multidrug resistance; Nanoparticle formulations; Tubulin dynamics; Tubulin inhibitors; Vascular disrupting agent; tubulin isotypes and drug resistance

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; DRUG CARRIER; NANOPARTICLE; PROTEIN BINDING; TUBULIN; TUBULIN MODULATOR;

EID: 84994059918     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules21111468     Document Type: Review
Times cited : (50)

References (120)
  • 2
    • 2542464892 scopus 로고    scopus 로고
    • Modulation of microtubule dynamics by tau in living cells: Implications for development and neurodegeneration
    • Bunker, J. M.; Wilson, L.; Jordan, M. A.; Feinstein, S. C. Modulation of microtubule dynamics by tau in living cells: Implications for development and neurodegeneration. Mol. Biol. Cell 2004, 15, 2720-2728.
    • (2004) Mol. Biol. Cell , vol.15 , pp. 2720-2728
    • Bunker, J.M.1    Wilson, L.2    Jordan, M.A.3    Feinstein, S.C.4
  • 3
    • 84946070830 scopus 로고    scopus 로고
    • Breast cancer cell lines exhibit differential sensitivities to microtubule-targeting drugs independent of doubling time
    • Risinger, A. L.; Dybdal-Hargreaves, N. F.; Mooberry, S. L. Breast cancer cell lines exhibit differential sensitivities to microtubule-targeting drugs independent of doubling time. Anticancer Res. 2015, 35, 5845-5850.
    • (2015) Anticancer Res. , vol.35 , pp. 5845-5850
    • Risinger, A.L.1    Dybdal-Hargreaves, N.F.2    Mooberry, S.L.3
  • 5
    • 77952193762 scopus 로고    scopus 로고
    • Microtubule dynamics, mitotic arrest, and apoptosis: Drug-induced differential effects of βIII-tubulin
    • Gan, P. P.; McCarroll, J. A.; Po'uha, S. T.; Kamath, K.; Jordan, M. A.; Kavallaris, M. Microtubule dynamics, mitotic arrest, and apoptosis: Drug-induced differential effects of βIII-tubulin. Mol. Cancer Ther. 2010, 9, 1339-1348.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 1339-1348
    • Gan, P.P.1    McCarroll, J.A.2    Po'Uha, S.T.3    Kamath, K.4    Jordan, M.A.5    Kavallaris, M.6
  • 6
    • 84918514058 scopus 로고    scopus 로고
    • The contribution of αβ-tubulin curvature to microtubule dynamics
    • Brouhard, G. J.; Rice, L. M. The contribution of αβ-tubulin curvature to microtubule dynamics. J. Cell Biol. 2014, 207, 323-334.
    • (2014) J. Cell Biol. , vol.207 , pp. 323-334
    • Brouhard, G.J.1    Rice, L.M.2
  • 7
    • 84954342035 scopus 로고    scopus 로고
    • Microtubule-stabilizing agents: New drug discovery and cancer therapy
    • Zhao, Y.; Mu, X.; Du, G. Microtubule-stabilizing agents: New drug discovery and cancer therapy. Pharmacol. Ther. 2016, 162, 134-143.
    • (2016) Pharmacol. Ther. , vol.162 , pp. 134-143
    • Zhao, Y.1    Mu, X.2    Du, G.3
  • 9
    • 58149347705 scopus 로고    scopus 로고
    • Microtubule active agents: Beyond the taxane frontier
    • Morris, P. G.; Fornier, M. N. Microtubule active agents: Beyond the taxane frontier. Clin. Cancer Res. 2008, 14, 7167-7172.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 7167-7172
    • Morris, P.G.1    Fornier, M.N.2
  • 10
    • 84941549087 scopus 로고    scopus 로고
    • Structural optimization of indole derivatives acting at colchicine binding site as potential anticancer agents
    • Hwang, D. J.; Wang, J.; Li, W.; Miller, D. D. Structural optimization of indole derivatives acting at colchicine binding site as potential anticancer agents. ACS Med. Chem. Lett. 2015, 6, 993-997.
    • (2015) ACS Med. Chem. Lett. , vol.6 , pp. 993-997
    • Hwang, D.J.1    Wang, J.2    Li, W.3    Miller, D.D.4
  • 12
    • 68849087436 scopus 로고    scopus 로고
    • Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance
    • Perez, E. A. Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance. Mol. Cancer Ther. 2009, 8, 2086-2095.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 2086-2095
    • Perez, E.A.1
  • 13
    • 1642401199 scopus 로고    scopus 로고
    • Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
    • Ravelli, R. B.; Gigant, B.; Curmi, P. A.; Jourdain, I.; Lachkar, S.; Sobel, A.; Knossow, M. Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain. Nature 2004, 428, 198-202.
    • (2004) Nature , vol.428 , pp. 198-202
    • Ravelli, R.B.1    Gigant, B.2    Curmi, P.A.3    Jourdain, I.4    Lachkar, S.5    Sobel, A.6    Knossow, M.7
  • 14
    • 84855833686 scopus 로고    scopus 로고
    • Vascular disrupting agents (VDA) in oncology: Advancing towards new therapeutic paradigms in the clinic
    • Spear, M. A.; LoRusso, P.; Mita, A.; Mita, M. Vascular disrupting agents (VDA) in oncology: Advancing towards new therapeutic paradigms in the clinic. Curr. Drug Targets 2011, 12, 2009-2015.
    • (2011) Curr. Drug Targets , vol.12 , pp. 2009-2015
    • Spear, M.A.1    LoRusso, P.2    Mita, A.3    Mita, M.4
  • 15
    • 78649833819 scopus 로고    scopus 로고
    • The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents
    • Siemann, D. W. The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents. Cancer Treat. Rev. 2011, 37, 63-74.
    • (2011) Cancer Treat. Rev. , vol.37 , pp. 63-74
    • Siemann, D.W.1
  • 16
    • 84879242784 scopus 로고    scopus 로고
    • Tumour vasculature targeting agents in hybrid/conjugate drugs
    • Prokopiou, E. M.; Ryder, S. A.; Walsh, J. J. Tumour vasculature targeting agents in hybrid/conjugate drugs. Angiogenesis 2013, 16, 503-524.
    • (2013) Angiogenesis , vol.16 , pp. 503-524
    • Prokopiou, E.M.1    Ryder, S.A.2    Walsh, J.J.3
  • 17
    • 84882705204 scopus 로고    scopus 로고
    • Regulation of tubulin expression by micro-RNA: Implications drug resistance
    • Lobert, S. G.; Mary, E. Regulation of tubulin expression by micro-RNA: Implications drug resistance. Methods Cell Biol. 2013, 115, 63-74.
    • (2013) Methods Cell Biol. , vol.115 , pp. 63-74
    • Lobert, S.G.1    Mary, E.2
  • 18
    • 84867889521 scopus 로고    scopus 로고
    • An overview of tubulin inhibitors that interact with the colchicine binding site
    • Lu, Y.; Chen, J.; Xiao, M.; Li, W.; Miller, D. D. An overview of tubulin inhibitors that interact with the colchicine binding site. Pharm. Res. 2012, 29, 2943-2971.
    • (2012) Pharm. Res. , vol.29 , pp. 2943-2971
    • Lu, Y.1    Chen, J.2    Xiao, M.3    Li, W.4    Miller, D.D.5
  • 19
    • 84924956325 scopus 로고    scopus 로고
    • Tubulin colchicine binding site inhibitors as vascular disrupting agents in clinical developments
    • Ji, Y. T.; Liu, Y. N.; Liu, Z. P. Tubulin colchicine binding site inhibitors as vascular disrupting agents in clinical developments. Curr. Med. Chem. 2015, 22, 1348-1360.
    • (2015) Curr. Med. Chem. , vol.22 , pp. 1348-1360
    • Ji, Y.T.1    Liu, Y.N.2    Liu, Z.P.3
  • 20
    • 84896876455 scopus 로고    scopus 로고
    • Optimization of 4-(N-cycloamino) phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site
    • Wang, X.-F.; Guan, F.; Ohkoshi, E.; Guo, W.; Wang, L.; Zhu, D.-Q.; Wang, S.-B.; Wang, L.-T.; Hamel, E.; Yang, D.; et al. Optimization of 4-(N-cycloamino) phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site. J. Med. Chem. 2014, 57, 1390-1402.
    • (2014) J. Med. Chem. , vol.57 , pp. 1390-1402
    • Wang, X.-F.1    Guan, F.2    Ohkoshi, E.3    Guo, W.4    Wang, L.5    Zhu, D.-Q.6    Wang, S.-B.7    Wang, L.-T.8    Hamel, E.9    Yang, D.10
  • 21
    • 84905814477 scopus 로고    scopus 로고
    • Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: Inhibitors of tubulin and angiogenesis
    • Solum, E. J.; Cheng, J.-J.; Sørvik, I. B.; Paulsen, R. E.; Vik, A.; Hansen, T. V. Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: Inhibitors of tubulin and angiogenesis. Eur. J. Med. Chem. 2014, 85, 391-398.
    • (2014) Eur. J. Med. Chem. , vol.85 , pp. 391-398
    • Solum, E.J.1    Cheng, J.-J.2    Sørvik, I.B.3    Paulsen, R.E.4    Vik, A.5    Hansen, T.V.6
  • 26
    • 84928893366 scopus 로고    scopus 로고
    • Systemic delivery of nanoparticle formulation of novel tubulin inhibitor for treating metastatic melanoma
    • Mundra, V.; Peng, Y.; Kumar, V.; Li, W.; Miller, D. D.; Mahato, R. I. Systemic delivery of nanoparticle formulation of novel tubulin inhibitor for treating metastatic melanoma. Drug Deliv. Transl. Res. 2015, 5, 199-208.
    • (2015) Drug Deliv. Transl. Res. , vol.5 , pp. 199-208
    • Mundra, V.1    Peng, Y.2    Kumar, V.3    Li, W.4    Miller, D.D.5    Mahato, R.I.6
  • 27
    • 84897071105 scopus 로고    scopus 로고
    • Etoposide loaded solid lipid nanoparticles for curtailing B16F10 melanoma colonization in lung
    • Athawale, R. B.; Jain, D. S.; Singh, K. K.; Gude, R. P. Etoposide loaded solid lipid nanoparticles for curtailing B16F10 melanoma colonization in lung. Biomed. Pharmacother. 2014, 68, 231-240.
    • (2014) Biomed. Pharmacother. , vol.68 , pp. 231-240
    • Athawale, R.B.1    Jain, D.S.2    Singh, K.K.3    Gude, R.P.4
  • 28
    • 84867869145 scopus 로고    scopus 로고
    • Formulation and characterization of polyester/polycarbonate nanoparticles for delivery of a novel microtubule destabilizing agent
    • Mundra, V.; Lu, Y.; Danquah, M.; Li, W.; Miller, D. D.; Mahato, R. I. Formulation and characterization of polyester/polycarbonate nanoparticles for delivery of a novel microtubule destabilizing agent. Pharm. Res. 2012, 29, 3064-3074.
    • (2012) Pharm. Res. , vol.29 , pp. 3064-3074
    • Mundra, V.1    Lu, Y.2    Danquah, M.3    Li, W.4    Miller, D.D.5    Mahato, R.I.6
  • 31
    • 49449119098 scopus 로고    scopus 로고
    • Antibody-drug conjugates for cancer therapy
    • Carter, P. J.; Senter, P. D. Antibody-drug conjugates for cancer therapy. Cancer J. 2008, 14, 154-169.
    • (2008) Cancer J. , vol.14 , pp. 154-169
    • Carter, P.J.1    Senter, P.D.2
  • 32
    • 84976870682 scopus 로고    scopus 로고
    • Antibody-drug conjugates for cancer therapy
    • Thomas, A.; Teicher, B. A.; Hassan, R. Antibody-drug conjugates for cancer therapy. Lancet Oncol. 2016, 17, e254-e262.
    • (2016) Lancet Oncol. , vol.17 , pp. e254-e262
    • Thomas, A.1    Teicher, B.A.2    Hassan, R.3
  • 33
    • 84948748686 scopus 로고    scopus 로고
    • Antibody drug conjugates for cancer therapy
    • Polakis, P. Antibody drug conjugates for cancer therapy. Pharmacol. Rev. 2016, 68, 3-19.
    • (2016) Pharmacol. Rev. , vol.68 , pp. 3-19
    • Polakis, P.1
  • 34
    • 34347207622 scopus 로고    scopus 로고
    • Polymer-drug conjugates as modulators of cellular apoptosis
    • Vicent, M. J. Polymer-drug conjugates as modulators of cellular apoptosis. AAPS J. 2007, 9, E200-E207.
    • (2007) AAPS J. , vol.9 , pp. E200-E207
    • Vicent, M.J.1
  • 36
    • 4344689901 scopus 로고    scopus 로고
    • Isolation, crystal and solution structure determination, and biosynthesis of tubulysins-Powerful inhibitors of tubulin polymerization from myxobacteria
    • Steinmetz, H.; Glaser, N.; Herdtweck, E.; Sasse, F.; Reichenbach, H.; Höfle, G. Isolation, crystal and solution structure determination, and biosynthesis of tubulysins-Powerful inhibitors of tubulin polymerization from myxobacteria. Angew. Chem. Int. Ed. Engl. 2004, 43, 4888-4892.
    • (2004) Angew. Chem. Int. Ed. Engl. , vol.43 , pp. 4888-4892
    • Steinmetz, H.1    Glaser, N.2    Herdtweck, E.3    Sasse, F.4    Reichenbach, H.5    Höfle, G.6
  • 37
    • 33645797560 scopus 로고    scopus 로고
    • Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria
    • Khalil, M. W.; Sasse, F.; Lünsdorf, H.; Elnakady, Y. A.; Reichenbach, H. Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria. ChemBioChem 2006, 7, 678-683.
    • (2006) ChemBioChem , vol.7 , pp. 678-683
    • Khalil, M.W.1    Sasse, F.2    Lünsdorf, H.3    Elnakady, Y.A.4    Reichenbach, H.5
  • 38
    • 84928885534 scopus 로고    scopus 로고
    • Chemistry and biology of tubulysins: Antimitotic tetrapeptides with activity against drug resistant cancers
    • Murray, B. C.; Peterson, M. T.; Fecik, R. A. Chemistry and biology of tubulysins: Antimitotic tetrapeptides with activity against drug resistant cancers. Nat. Prod. Rep. 2015, 32, 654-662.
    • (2015) Nat. Prod. Rep. , vol.32 , pp. 654-662
    • Murray, B.C.1    Peterson, M.T.2    Fecik, R.A.3
  • 41
    • 84888058685 scopus 로고    scopus 로고
    • Recent advances in the synthesis of tubulysins
    • Xu, X.; Gregory, K. F.; Yao, L. Recent advances in the synthesis of tubulysins. Mini Rev. Med. Chem. 2013, 13, 1572-1578.
    • (2013) Mini Rev. Med. Chem. , vol.13 , pp. 1572-1578
    • Xu, X.1    Gregory, K.F.2    Yao, L.3
  • 42
    • 84885746124 scopus 로고    scopus 로고
    • Does trastuzumab-emtansine have better cardiac safety profile in contrast to trastuzumab?
    • Sendur, M. A.; Aksoy, S.; Ozdemir, Y.; Zengin, N.; Altundag, K. Does trastuzumab-emtansine have better cardiac safety profile in contrast to trastuzumab? J. BUON 2013, 18, 801.
    • (2013) J. BUON , vol.18 , pp. 801
    • Sendur, M.A.1    Aksoy, S.2    Ozdemir, Y.3    Zengin, N.4    Altundag, K.5
  • 43
    • 84880229916 scopus 로고    scopus 로고
    • Trastuzumab emtansine in the treatment of HER-2-positive metastatic breast cancer patients
    • Bighin, C.; Pronzato, P.; Del Mastro, L. Trastuzumab emtansine in the treatment of HER-2-positive metastatic breast cancer patients. Future Oncol. 2013, 9, 955-957.
    • (2013) Future Oncol. , vol.9 , pp. 955-957
    • Bighin, C.1    Pronzato, P.2    Del Mastro, L.3
  • 44
    • 84888201843 scopus 로고    scopus 로고
    • Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability
    • Poon, K. A.; Flagella, K.; Beyer, J.; Tibbitts, J.; Kaur, S.; Saad, O.; Yi, J. H.; Girish, S.; Dybdal, N.; Reynolds, T. Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability. Toxicol. Appl. Pharmacol. 2013, 273, 298-313.
    • (2013) Toxicol. Appl. Pharmacol. , vol.273 , pp. 298-313
    • Poon, K.A.1    Flagella, K.2    Beyer, J.3    Tibbitts, J.4    Kaur, S.5    Saad, O.6    Yi, J.H.7    Girish, S.8    Dybdal, N.9    Reynolds, T.10
  • 45
    • 84919933115 scopus 로고    scopus 로고
    • Enhanced anticancer activity of DM1-loaded star-shaped folate-core PLA-TPGS nanoparticles
    • Tang, X.; Liang, Y.; Zhu, Y.; Cai, S.; Sun, L.; Chen, T. Enhanced anticancer activity of DM1-loaded star-shaped folate-core PLA-TPGS nanoparticles. Nanoscale Res. Lett. 2014, 9.
    • (2014) Nanoscale Res. Lett. , pp. 9
    • Tang, X.1    Liang, Y.2    Zhu, Y.3    Cai, S.4    Sun, L.5    Chen, T.6
  • 46
    • 84890403198 scopus 로고    scopus 로고
    • Trastuzumab emtansine for the treatment of HER2-positive metastatic breast cancer
    • Haddley, K. Trastuzumab emtansine for the treatment of HER2-positive metastatic breast cancer. Drugs Today 2013, 49, 701-715.
    • (2013) Drugs Today , vol.49 , pp. 701-715
    • Haddley, K.1
  • 47
    • 84896696101 scopus 로고    scopus 로고
    • Resistance to human epidermal growth factor receptor type 2-targeted therapies
    • Thery, J.-C.; Spano, J.-P.; Azria, D.; Raymond, E.; Penault Llorca, F. Resistance to human epidermal growth factor receptor type 2-targeted therapies. Eur. J. Cancer 2014, 50, 892-901.
    • (2014) Eur. J. Cancer , vol.50 , pp. 892-901
    • Thery, J.-C.1    Spano, J.-P.2    Azria, D.3    Raymond, E.4    Penault Llorca, F.5
  • 48
    • 84900433657 scopus 로고    scopus 로고
    • Folate receptor-targeted liposomes enhanced the antitumor potency of imatinib through the combination of active targeting and molecular targeting
    • Ye, P.; Zhang, W.; Yang, T.; Lu, Y.; Lu, M.; Gai, Y.; Ma, X.; Xiang, G. Folate receptor-targeted liposomes enhanced the antitumor potency of imatinib through the combination of active targeting and molecular targeting. Int. J. Nanomed. 2014, 9, 2167-2178.
    • (2014) Int. J. Nanomed. , vol.9 , pp. 2167-2178
    • Ye, P.1    Zhang, W.2    Yang, T.3    Lu, Y.4    Lu, M.5    Gai, Y.6    Ma, X.7    Xiang, G.8
  • 49
    • 84904159493 scopus 로고    scopus 로고
    • Small molecule-folic acid modification on nanopatterned PDMS and investigation on its surface property
    • Hu, Y.; Ma, B.; Zhang, Y.; Wang, M. Small molecule-folic acid modification on nanopatterned PDMS and investigation on its surface property. Biomed. Microdevices 2014, 16, 487-497.
    • (2014) Biomed. Microdevices , vol.16 , pp. 487-497
    • Hu, Y.1    Ma, B.2    Zhang, Y.3    Wang, M.4
  • 51
    • 84899908927 scopus 로고    scopus 로고
    • A fullerene-based multi-functional nanoplatform for cancer theranostic applications
    • Shi, J.; Wang, L.; Gao, J.; Liu, Y.; Zhang, J.; Ma, R.; Liu, R.; Zhang, Z. A fullerene-based multi-functional nanoplatform for cancer theranostic applications. Biomaterials 2014, 35, 5771-5784.
    • (2014) Biomaterials , vol.35 , pp. 5771-5784
    • Shi, J.1    Wang, L.2    Gao, J.3    Liu, Y.4    Zhang, J.5    Ma, R.6    Liu, R.7    Zhang, Z.8
  • 52
    • 84900853302 scopus 로고    scopus 로고
    • Robust ICG theranostic nanoparticles for folate targeted cancer imaging and highly effective photothermal therapy
    • Zheng, M.; Zhao, P.; Luo, Z.; Gong, P.; Zheng, C.; Zhang, P.; Yue, C.; Gao, D.; Ma, Y.; Cai, L. Robust ICG theranostic nanoparticles for folate targeted cancer imaging and highly effective photothermal therapy. ACS Appl. Mater. Interfaces 2014, 6, 6709-6716.
    • (2014) ACS Appl. Mater. Interfaces , vol.6 , pp. 6709-6716
    • Zheng, M.1    Zhao, P.2    Luo, Z.3    Gong, P.4    Zheng, C.5    Zhang, P.6    Yue, C.7    Gao, D.8    Ma, Y.9    Cai, L.10
  • 53
    • 79953048071 scopus 로고    scopus 로고
    • Tumor delivery of macromolecular drugs based on the EPR effect
    • Torchilin, V. Tumor delivery of macromolecular drugs based on the EPR effect. Adv. Drug Deliv. Rev. 2011, 63, 131-135.
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , pp. 131-135
    • Torchilin, V.1
  • 54
    • 84973644247 scopus 로고    scopus 로고
    • A-cyclodextrin interacts close to vinblastine site of tubulin and delivers curcumin preferentially to the tubulin surface of cancer cell
    • Jana, B.; Mohapatra, S.; Mondal, P.; Barman, S.; Pradhan, K.; Saha, A.; Ghosh, S. A-cyclodextrin interacts close to vinblastine site of tubulin and delivers curcumin preferentially to the tubulin surface of cancer cell. ACS Appl. Mater. Interfaces 2016, 8, 13793-13803.
    • (2016) ACS Appl. Mater. Interfaces , vol.8 , pp. 13793-13803
    • Jana, B.1    Mohapatra, S.2    Mondal, P.3    Barman, S.4    Pradhan, K.5    Saha, A.6    Ghosh, S.7
  • 55
    • 84991409677 scopus 로고    scopus 로고
    • Blocking blood flow to solid tumors by destabilizing tubulin: An approach to targeting tumor growth
    • Pérez-Pérez, M.-J.; Priego, E.-M.; Bueno, O.; Martins, M. S.; Canela, M.-D.; Liekens, S. Blocking blood flow to solid tumors by destabilizing tubulin: An approach to targeting tumor growth. J. Med. Chem. 2016, 59, 8685-8711.
    • (2016) J. Med. Chem. , vol.59 , pp. 8685-8711
    • Pérez-Pérez, M.-J.1    Priego, E.-M.2    Bueno, O.3    Martins, M.S.4    Canela, M.-D.5    Liekens, S.6
  • 56
    • 84906874813 scopus 로고    scopus 로고
    • Repurposing an erstwhile cancer drug: A quantitative and therapeutic evaluation of alternative nanosystems for the delivery of colchicine to solid tumors
    • Tangutoori, S.; Ohta, A.; Gatley, S.; Campbell, B. R. Repurposing an erstwhile cancer drug: A quantitative and therapeutic evaluation of alternative nanosystems for the delivery of colchicine to solid tumors. J. Cancer Sci. Ther. 2014, 6, 236-246.
    • (2014) J. Cancer Sci. Ther. , vol.6 , pp. 236-246
    • Tangutoori, S.1    Ohta, A.2    Gatley, S.3    Campbell, B.R.4
  • 58
    • 3042835326 scopus 로고    scopus 로고
    • Colchicine poisoning: Case report of two suicides
    • Deveaux, M.; Hubert, N.; Demarly, C. Colchicine poisoning: Case report of two suicides. Forensic. Sci. Int. 2004, 143, 219-222.
    • (2004) Forensic. Sci. Int. , vol.143 , pp. 219-222
    • Deveaux, M.1    Hubert, N.2    Demarly, C.3
  • 59
    • 84904399318 scopus 로고    scopus 로고
    • Refractory shock and severe leukopenia with multisystemic organ failure due to colchicine intentional overdose
    • Fernandez, S.; Castro, P.; Nogue, S.; Nicolas, J. M. Refractory shock and severe leukopenia with multisystemic organ failure due to colchicine intentional overdose. Med. Clin. 2014, 143, 140.
    • (2014) Med. Clin. , vol.143 , pp. 140
    • Fernandez, S.1    Castro, P.2    Nogue, S.3    Nicolas, J.M.4
  • 61
    • 64349111929 scopus 로고    scopus 로고
    • Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: Synthesis, biological evaluation, and structure-activity relationships
    • Lu, Y.; Li, C.-M.; Wang, Z.; Ross, C. R.; Chen, J.; Dalton, J. T.; Li, W.; Miller, D. D. Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: Synthesis, biological evaluation, and structure-activity relationships. J. Med. Chem. 2009, 52, 1701-1711.
    • (2009) J. Med. Chem. , vol.52 , pp. 1701-1711
    • Lu, Y.1    Li, C.-M.2    Wang, Z.3    Ross, C.R.4    Chen, J.5    Dalton, J.T.6    Li, W.7    Miller, D.D.8
  • 62
    • 79960151500 scopus 로고    scopus 로고
    • Design, synthesis, and sar studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents
    • Lu, Y.; Li, C.-M.; Wang, Z.; Chen, J.; Mohler, M. L.; Li, W.; Dalton, J. T.; Miller, D. D. Design, synthesis, and sar studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents. J. Med. Chem. 2011, 54, 4678-4693.
    • (2011) J. Med. Chem. , vol.54 , pp. 4678-4693
    • Lu, Y.1    Li, C.-M.2    Wang, Z.3    Chen, J.4    Mohler, M.L.5    Li, W.6    Dalton, J.T.7    Miller, D.D.8
  • 63
  • 64
    • 84952762147 scopus 로고    scopus 로고
    • Tumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor
    • Li, X.; Wu, M.; Pan, L.; Shi, J. Tumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor. Int. J. Nanomed. 2016, 11, 93-105.
    • (2016) Int. J. Nanomed. , vol.11 , pp. 93-105
    • Li, X.1    Wu, M.2    Pan, L.3    Shi, J.4
  • 65
    • 84968883517 scopus 로고    scopus 로고
    • Combretastatin A-4 conjugated antiangiogenic micellar drug delivery systems using dendron-polymer conjugates
    • Sumer Bolu, B.; Manavoglu Gecici, E.; Sanyal, R. Combretastatin A-4 conjugated antiangiogenic micellar drug delivery systems using dendron-polymer conjugates. Mol. Pharm. 2016, 13, 1482-1490.
    • (2016) Mol. Pharm. , vol.13 , pp. 1482-1490
    • Sumer Bolu, B.1    Manavoglu Gecici, E.2    Sanyal, R.3
  • 67
    • 70350134980 scopus 로고    scopus 로고
    • Sparc expression correlates with tumor response to albumin-bound paclitaxel in head and neck cancer patients
    • Desai, N.; Trieu, V.; Damascelli, B.; Soon-Shiong, P. Sparc expression correlates with tumor response to albumin-bound paclitaxel in head and neck cancer patients. Transl. Oncol. 2009, 2, 59-64.
    • (2009) Transl. Oncol. , vol.2 , pp. 59-64
    • Desai, N.1    Trieu, V.2    Damascelli, B.3    Soon-Shiong, P.4
  • 68
    • 84879306090 scopus 로고    scopus 로고
    • Successful treatment with nab-paclitaxel after hypersensitivity reaction to paclitaxel and docetaxel
    • De Leon, M. C. B.; Bolla, S.; Greene, B.; Hutchinson, L.; Del Priore, G. Successful treatment with nab-paclitaxel after hypersensitivity reaction to paclitaxel and docetaxel. Gynecol. Oncol. Case Rep. 2013, 5, 70-71.
    • (2013) Gynecol. Oncol. Case Rep. , vol.5 , pp. 70-71
    • De Leon, M.C.B.1    Bolla, S.2    Greene, B.3    Hutchinson, L.4    Del Priore, G.5
  • 70
    • 7044231274 scopus 로고    scopus 로고
    • Response to paclitaxel, topotecan, and topotecan-cyclophosphamide in children with untreated disseminated neuroblastoma treated in an upfront phase II investigational window: A pediatric oncology group study
    • Kretschmar, C. S.; Kletzel, M.; Murray, K.; Thorner, P.; Joshi, V.; Marcus, R.; Smith, E. I.; London, W. B.; Castleberry, R. Response to paclitaxel, topotecan, and topotecan-cyclophosphamide in children with untreated disseminated neuroblastoma treated in an upfront phase II investigational window: A pediatric oncology group study. J. Clin. Oncol. 2004, 22, 4119-4126.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 4119-4126
    • Kretschmar, C.S.1    Kletzel, M.2    Murray, K.3    Thorner, P.4    Joshi, V.5    Marcus, R.6    Smith, E.I.7    London, W.B.8    Castleberry, R.9
  • 74
    • 52649119391 scopus 로고    scopus 로고
    • Improved effectiveness of nanoparticle albumin-bound (nab) paclitaxel versus polysorbate-based docetaxel in multiple xenografts as a function of HER2 and SPARC status
    • Desai, N. P.; Trieu, V.; Hwang, L. Y.; Wu, R.; Soon-Shiong, P.; Gradishar, W. J. Improved effectiveness of nanoparticle albumin-bound (nab) paclitaxel versus polysorbate-based docetaxel in multiple xenografts as a function of HER2 and SPARC status. Anti-Cancer Drugs 2008, 19, 899-909.
    • (2008) Anti-Cancer Drugs , vol.19 , pp. 899-909
    • Desai, N.P.1    Trieu, V.2    Hwang, L.Y.3    Wu, R.4    Soon-Shiong, P.5    Gradishar, W.J.6
  • 75
    • 27644562207 scopus 로고    scopus 로고
    • Association of paclitaxel pharmacokinetics with the development of peripheral neuropathy in patients with advanced cancer
    • Mielke, S.; Sparreboom, A.; Steinberg, S. M.; Gelderblom, H.; Unger, C.; Behringer, D.; Mross, K. Association of paclitaxel pharmacokinetics with the development of peripheral neuropathy in patients with advanced cancer. Clin. Cancer Res. 2005, 11, 4843-4850.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 4843-4850
    • Mielke, S.1    Sparreboom, A.2    Steinberg, S.M.3    Gelderblom, H.4    Unger, C.5    Behringer, D.6    Mross, K.7
  • 76
    • 29144478503 scopus 로고    scopus 로고
    • Peripheral neuropathy: A persisting challenge in paclitaxel-based regimes
    • Mielke, S.; Sparreboom, A.; Mross, K. Peripheral neuropathy: A persisting challenge in paclitaxel-based regimes. Eur. J. Cancer 2006, 42, 24-30.
    • (2006) Eur. J. Cancer , vol.42 , pp. 24-30
    • Mielke, S.1    Sparreboom, A.2    Mross, K.3
  • 77
    • 0032801015 scopus 로고    scopus 로고
    • Cremophor reduces paclitaxel penetration into bladder wall during intravesical treatment
    • Knemeyer, I.; Wientjes, G. M.; Au, L. S. J. Cremophor reduces paclitaxel penetration into bladder wall during intravesical treatment. Cancer Chemother. Pharmacol. 1999, 44, 241-248.
    • (1999) Cancer Chemother. Pharmacol. , vol.44 , pp. 241-248
    • Knemeyer, I.1    Wientjes, G.M.2    Au, L.S.J.3
  • 78
    • 32944482677 scopus 로고    scopus 로고
    • Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
    • Gradishar, W. J.; Tjulandin, S.; Davidson, N.; Shaw, H.; Desai, N.; Bhar, P.; Hawkins, M.; O'Shaughnessy, J. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J. Clin. Oncol. 2005, 23, 7794-7803.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 7794-7803
    • Gradishar, W.J.1    Tjulandin, S.2    Davidson, N.3    Shaw, H.4    Desai, N.5    Bhar, P.6    Hawkins, M.7    O'Shaughnessy, J.8
  • 79
    • 84941888689 scopus 로고    scopus 로고
    • Albumin-bound paclitaxel in solid tumors: Clinical development and future directions
    • Kundranda, M. N.; Niu, J. Albumin-bound paclitaxel in solid tumors: Clinical development and future directions. Drug Des. Dev. Ther. 2015, 9, 3767-3777.
    • (2015) Drug Des. Dev. Ther. , vol.9 , pp. 3767-3777
    • Kundranda, M.N.1    Niu, J.2
  • 80
    • 84891510634 scopus 로고    scopus 로고
    • First line treatment of advanced non-small-cell lung cancer-Specific focus on albumin bound paclitaxel
    • Gupta, N.; Hatoum, H.; Dy, G. K. First line treatment of advanced non-small-cell lung cancer-Specific focus on albumin bound paclitaxel. Int. J. Nanomed. 2014, 9, 209-221.
    • (2014) Int. J. Nanomed. , vol.9 , pp. 209-221
    • Gupta, N.1    Hatoum, H.2    Dy, G.K.3
  • 82
    • 79959413829 scopus 로고    scopus 로고
    • Design and development of paclitaxel-loaded bovine serum albumin nanoparticles for brain targeting
    • Bansal, A.; Kapoor, D. N.; Kapil, R.; Chhabra, N.; Dhawan, S. Design and development of paclitaxel-loaded bovine serum albumin nanoparticles for brain targeting. Acta Pharm. 2011, 61, 141-156.
    • (2011) Acta Pharm. , vol.61 , pp. 141-156
    • Bansal, A.1    Kapoor, D.N.2    Kapil, R.3    Chhabra, N.4    Dhawan, S.5
  • 83
    • 84947279586 scopus 로고    scopus 로고
    • Improved anti-glioblastoma efficacy by IL-13Rα2 mediated copolymer nanoparticles loaded with paclitaxel
    • Wang, B.; Lv, L.; Wang, Z.; Jiang, Y.; Lv, W.; Liu, X.; Wang, Z.; Zhao, Y.; Xin, H.; Xu, Q. Improved anti-glioblastoma efficacy by IL-13Rα2 mediated copolymer nanoparticles loaded with paclitaxel. Sci. Rep. 2015, 5.
    • (2015) Sci. Rep. , pp. 5
    • Wang, B.1    Lv, L.2    Wang, Z.3    Jiang, Y.4    Lv, W.5    Liu, X.6    Wang, Z.7    Zhao, Y.8    Xin, H.9    Xu, Q.10
  • 84
    • 84946554367 scopus 로고    scopus 로고
    • Co-delivery of pirarubicin and paclitaxel by human serum albumin nanoparticles to enhance antitumor effect and reduce systemic toxicity in breast cancers
    • Yi, X.; Lian, X.; Dong, J.; Wan, Z.; Xia, C.; Song, X.; Fu, Y.; Gong, T.; Zhang, Z. Co-delivery of pirarubicin and paclitaxel by human serum albumin nanoparticles to enhance antitumor effect and reduce systemic toxicity in breast cancers. Mol. Pharm. 2015, 12, 4085-4098.
    • (2015) Mol. Pharm. , vol.12 , pp. 4085-4098
    • Yi, X.1    Lian, X.2    Dong, J.3    Wan, Z.4    Xia, C.5    Song, X.6    Fu, Y.7    Gong, T.8    Zhang, Z.9
  • 86
    • 46749126105 scopus 로고    scopus 로고
    • Selective destruction of the tumour vasculature by targeting the endothelial cytoskeleton
    • Kanthou, C.; Tozer, G. M. Selective destruction of the tumour vasculature by targeting the endothelial cytoskeleton. Drug Discov. Today. Ther. Strateg. 2007, 4, 237-243.
    • (2007) Drug Discov. Today. Ther. Strateg. , vol.4 , pp. 237-243
    • Kanthou, C.1    Tozer, G.M.2
  • 88
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • Carmeliet, P. Angiogenesis in life, disease and medicine. Nature 2005, 438, 932-936.
    • (2005) Nature , vol.438 , pp. 932-936
    • Carmeliet, P.1
  • 89
    • 84885106382 scopus 로고    scopus 로고
    • Angiogenesis inhibitors in cancer therapy: Mechanistic perspective on classification and treatment rationales
    • El-Kenawi, A. E.; El-Remessy, A. B. Angiogenesis inhibitors in cancer therapy: Mechanistic perspective on classification and treatment rationales. Br. J. Pharmacol. 2013, 170, 712-729.
    • (2013) Br. J. Pharmacol. , vol.170 , pp. 712-729
    • El-Kenawi, A.E.1    El-Remessy, A.B.2
  • 90
    • 84903901969 scopus 로고    scopus 로고
    • Anti-angiogenic therapy for cancer: Current progress, unresolved questions and future directions
    • Vasudev, N. S.; Reynolds, A. R. Anti-angiogenic therapy for cancer: Current progress, unresolved questions and future directions. Angiogenesis 2014, 17, 471-494.
    • (2014) Angiogenesis , vol.17 , pp. 471-494
    • Vasudev, N.S.1    Reynolds, A.R.2
  • 93
    • 84958532480 scopus 로고    scopus 로고
    • Peloruside a is a microtubule-stabilizing agent with exceptional anti-migratory properties in human endothelial cells
    • Ganguly, A.; Cabral, F.; Yang, H.; Patel, K. D. Peloruside a is a microtubule-stabilizing agent with exceptional anti-migratory properties in human endothelial cells. Oncoscience 2015, 2, 585-595.
    • (2015) Oncoscience , vol.2 , pp. 585-595
    • Ganguly, A.1    Cabral, F.2    Yang, H.3    Patel, K.D.4
  • 95
    • 84937764979 scopus 로고    scopus 로고
    • Inhibition of human vascular endothelial cell migration and capillary-like tube formation by the microtubule-stabilizing agent peloruside A
    • Chan, A.; Singh, A. J.; Northcote, P. T.; Miller, J. H. Inhibition of human vascular endothelial cell migration and capillary-like tube formation by the microtubule-stabilizing agent peloruside A. Investig. New Drugs 2015, 33, 564-574.
    • (2015) Investig. New Drugs , vol.33 , pp. 564-574
    • Chan, A.1    Singh, A.J.2    Northcote, P.T.3    Miller, J.H.4
  • 96
    • 84879238014 scopus 로고    scopus 로고
    • The pharmacological bases of the antiangiogenic activity of paclitaxel
    • Bocci, G.; Di Paolo, A.; Danesi, R. The pharmacological bases of the antiangiogenic activity of paclitaxel. Angiogenesis 2013, 16, 481-492.
    • (2013) Angiogenesis , vol.16 , pp. 481-492
    • Bocci, G.1    Di Paolo, A.2    Danesi, R.3
  • 97
    • 33645103854 scopus 로고    scopus 로고
    • The microtubule binding drug laulimalide inhibits vascular endothelial growth factor-induced human endothelial cell migration and is synergistic when combined with docetaxel (taxotere)
    • Lu, H.; Murtagh, J.; Schwartz, E. L. The microtubule binding drug laulimalide inhibits vascular endothelial growth factor-induced human endothelial cell migration and is synergistic when combined with docetaxel (taxotere). Mol. Pharmacol. 2006, 69, 1207-1215.
    • (2006) Mol. Pharmacol. , vol.69 , pp. 1207-1215
    • Lu, H.1    Murtagh, J.2    Schwartz, E.L.3
  • 99
    • 0023801309 scopus 로고
    • Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: A structure-activity study
    • Lin, C. M.; Singh, S. B.; Chu, P. S.; Dempcy, R. O.; Schmidt, J. M.; Pettit, G. R.; Hamel, E. Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: A structure-activity study. Mol. Pharmacol. 1988, 34, 200-208.
    • (1988) Mol. Pharmacol. , vol.34 , pp. 200-208
    • Lin, C.M.1    Singh, S.B.2    Chu, P.S.3    Dempcy, R.O.4    Schmidt, J.M.5    Pettit, G.R.6    Hamel, E.7
  • 101
    • 25844502482 scopus 로고    scopus 로고
    • Plant-based anticancer molecules: A chemical and biological profile of some important leads
    • Srivastava, V.; Negi, A. S.; Kumar, J. K.; Gupta, M. M.; Khanuja, S. P. S. Plant-based anticancer molecules: A chemical and biological profile of some important leads. Bioorg. Med. Chem. 2005, 13, 5892-5908.
    • (2005) Bioorg. Med. Chem. , vol.13 , pp. 5892-5908
    • Srivastava, V.1    Negi, A.S.2    Kumar, J.K.3    Gupta, M.M.4    Khanuja, S.P.S.5
  • 102
    • 4444372391 scopus 로고    scopus 로고
    • Lack of neurotoxicity of the vascular targeting agent ZD6126 following repeated i.v. Dosing in the rat
    • Horner, S. A.; Gould, S.; Noakes, J. P.; Rattray, N. J.; Allen, S. L.; Zotova, E.; Arezzo, J. C. Lack of neurotoxicity of the vascular targeting agent ZD6126 following repeated i.v. Dosing in the rat. Mol. Cancer Ther. 2004, 3, 783-791.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 783-791
    • Horner, S.A.1    Gould, S.2    Noakes, J.P.3    Rattray, N.J.4    Allen, S.L.5    Zotova, E.6    Arezzo, J.C.7
  • 103
    • 33750539995 scopus 로고    scopus 로고
    • Vascular disrupting agents
    • Pilat, M. J.; LoRusso, P. M. Vascular disrupting agents. J. Cell. Biochem. 2006, 99, 1021-1039.
    • (2006) J. Cell. Biochem. , vol.99 , pp. 1021-1039
    • Pilat, M.J.1    LoRusso, P.M.2
  • 104
    • 77956336496 scopus 로고    scopus 로고
    • Discovery of a potent tubulin polymerization inhibitor: Synthesis and evaluation of water-soluble prodrugs of benzophenone analog
    • Lee, J.; Bae, S.; Lee, S.-H.; Choi, H.; Kim, Y. H.; Kim, S. J.; Park, G. T.; Moon, S. K.; Kim, D.-H.; Lee, S.; et al. Discovery of a potent tubulin polymerization inhibitor: Synthesis and evaluation of water-soluble prodrugs of benzophenone analog. Bioorg. Med. Chem. Lett. 2010, 20, 6327-6330.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 6327-6330
    • Lee, J.1    Bae, S.2    Lee, S.-H.3    Choi, H.4    Kim, Y.H.5    Kim, S.J.6    Park, G.T.7    Moon, S.K.8    Kim, D.-H.9    Lee, S.10
  • 105
    • 77956298509 scopus 로고    scopus 로고
    • Identification of CKD-516: A potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors
    • Lee, J.; Kim, S. J.; Choi, H.; Kim, Y. H.; Lim, I. T.; Yang, H.-M.; Lee, C. S.; Kang, H. R.; Ahn, S. K.; Moon, S. K.; et al. Identification of CKD-516: A potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. J. Med. Chem. 2010, 53, 6337-6354.
    • (2010) J. Med. Chem. , vol.53 , pp. 6337-6354
    • Lee, J.1    Kim, S.J.2    Choi, H.3    Kim, Y.H.4    Lim, I.T.5    Yang, H.-M.6    Lee, C.S.7    Kang, H.R.8    Ahn, S.K.9    Moon, S.K.10
  • 108
  • 109
    • 79961012608 scopus 로고    scopus 로고
    • Clinical, pharmacodynamic, and pharmacokinetic evaluation of BNC105P: A phase I trial of a novel vascular disrupting agent and inhibitor of cancer cell proliferation
    • Rischin, D.; Bibby, D. C.; Chong, G.; Kremmidiotis, G.; Leske, A. F.; Matthews, C. A.; Wong, S. S.; Rosen, M. A.; Desai, J. Clinical, pharmacodynamic, and pharmacokinetic evaluation of BNC105P: A phase I trial of a novel vascular disrupting agent and inhibitor of cancer cell proliferation. Clin. Cancer Res. 2011, 17, 5152-5160.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 5152-5160
    • Rischin, D.1    Bibby, D.C.2    Chong, G.3    Kremmidiotis, G.4    Leske, A.F.5    Matthews, C.A.6    Wong, S.S.7    Rosen, M.A.8    Desai, J.9
  • 110
    • 80054903481 scopus 로고    scopus 로고
    • Water-soluble prodrug of antimicrotubule agent plinabulin: Effective strategy with click chemistry
    • Yakushiji, F.; Tanaka, H.; Muguruma, K.; Iwahashi, T.; Yamazaki, Y.; Hayashi, Y. Water-soluble prodrug of antimicrotubule agent plinabulin: Effective strategy with click chemistry. Chem. Eur. J. 2011, 17, 12587-12590.
    • (2011) Chem. Eur. J. , vol.17 , pp. 12587-12590
    • Yakushiji, F.1    Tanaka, H.2    Muguruma, K.3    Iwahashi, T.4    Yamazaki, Y.5    Hayashi, Y.6
  • 118
    • 84897985946 scopus 로고    scopus 로고
    • Effects of the tumor-vasculaturedisrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels
    • Mahal, K.; Resch, M.; Ficner, R.; Schobert, R.; Biersack, B.; Mueller, T. Effects of the tumor-vasculaturedisrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels. ChemMedChem 2014, 9, 847-854.
    • (2014) ChemMedChem , vol.9 , pp. 847-854
    • Mahal, K.1    Resch, M.2    Ficner, R.3    Schobert, R.4    Biersack, B.5    Mueller, T.6
  • 119
    • 84884537169 scopus 로고    scopus 로고
    • Chromenes: Potential new chemotherapeutic agents for cancer
    • Patil, S. A.; Patil, R.; Pfeffer, L. M.; Miller, D. D. Chromenes: Potential new chemotherapeutic agents for cancer. Future Med. Chem. 2013, 5, 1647-1660.
    • (2013) Future Med. Chem. , vol.5 , pp. 1647-1660
    • Patil, S.A.1    Patil, R.2    Pfeffer, L.M.3    Miller, D.D.4
  • 120
    • 84947967805 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of novel 5H-chromenopyridines as potential anti-cancer agents
    • Banerjee, S.; Wang, J.; Pfeffer, S.; Ma, D.; Pfeffer, L.; Patil, S.; Li, W.; Miller, D. Design, synthesis and biological evaluation of novel 5H-chromenopyridines as potential anti-cancer agents. Molecules 2015, 20, 17152-17165.
    • (2015) Molecules , vol.20 , pp. 17152-17165
    • Banerjee, S.1    Wang, J.2    Pfeffer, S.3    Ma, D.4    Pfeffer, L.5    Patil, S.6    Li, W.7    Miller, D.8


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