Roles of NHERF Family of PDZ-Binding Proteins in Regulating GPCR Functions

Advances in Immunology

Volumn 136, Issue , 2017, Pages 353-385

  Broadbent, David ^a   Ahmadzai, Mohammad M ^a   Kammala, Ananth K ^a   Yang, Canchai ^a   Occhiuto, Christopher ^a   Das, Rupali ^a   Subramanian, Hariharan ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

CFTR; EBP50; G protein coupled receptors; Na+ H+ exchanger regulatory factor 1; NHERFs; PDZ proteins; PDZK1

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA CATENIN; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; G PROTEIN COUPLED RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR 2; PARATHYROID HORMONE RECEPTOR; PDZ PROTEIN; PHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOLIPASE C BETA; PURINERGIC P2Y1 RECEPTOR; SERINE; SODIUM PHOSPHATE COTRANSPORTER 2A; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN 2; SODIUM PROTON EXCHANGE PROTEIN 3; SODIUM PROTON EXCHANGE PROTEIN 4; UNCLASSIFIED DRUG; UVOMORULIN; PHOSPHOPROTEIN; PROTEIN BINDING; SODIUM-HYDROGEN EXCHANGER REGULATORY FACTOR;

CANCER INHIBITION; CELL MEMBRANE; CLASSIFICATION; CYSTIC FIBROSIS; CYTOSOL; DIMERIZATION; ENDOCYTOSIS; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; IMMUNITY; INFLAMMATION; ION TRANSPORT; MALIGNANT NEOPLASM; MAST CELL; NONHUMAN; PATHOGENESIS; PDZ DOMAIN; PHOSPHATE REABSORPTION; PHOSPHATE TRANSPORT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ANIMAL; CARCINOGENESIS; CELL COMMUNICATION; CELLULAR IMMUNITY; GENETICS; KIDNEY; METABOLISM; MOLECULARLY TARGETED THERAPY; PHYSIOLOGY; PROTEIN TRANSPORT;

ANIMALS; CARCINOGENESIS; CELL COMMUNICATION; HUMANS; IMMUNITY, CELLULAR; ION TRANSPORT; KIDNEY; MOLECULAR TARGETED THERAPY; PDZ DOMAINS; PHOSPHATES; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN TRANSPORT; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN EXCHANGERS;

EID: 85022187687     PISSN: 00652776     EISSN: 15578445     Source Type: Book Series    
DOI: 10.1016/bs.ai.2017.05.008     Document Type: Chapter

References (130)

1. Ali, H., Regulation of human mast cell and basophil function by anaphylatoxins C3a and C5a. Immunology Letters 128 (2010), 36–45.
2. Ardura, J.A., Friedman, P.A., Regulation of G protein-coupled receptor function by Na +/H + exchange regulatory factors. Pharmacological Reviews 63 (2011), 882–900.
3. Audrézet, M.P., Chen, J.M., Le Maréchal, C., Ruszniewski, P., Robaszkiewicz, M., Raguénès, O., et al. Determination of the relative contribution of three genes-the cystic fibrosis transmembrane conductance regulator gene, the cationic trypsinogen gene, and the pancreatic secretory trypsin inhibitor gene-to the etiology of idiopathic chronic pancreatitis. European Journal of Human Genetics 10 (2002), 100–106.
4. Bai, X., Miao, D., Goltzman, D., Karaplis, A.C., Early lethality in Hyp mice with targeted deletion of PTH gene. Endocrinology 148 (2007), 4974–4983.
5. Bandeira, F., Cusano, N.E., Silva, B.C., Cassibba, S., Almeida, C.B., Machado, V.C., et al. Bone disease in primary hyperparathyroidism. Arquivos Brasileiros de Endocrinologia e Metabologia 58 (2014), 553–561.
6. Beck, L., Karaplis, A.C., Amizuka, N., Hewson, A.S., Ozawa, H., Tenenhouse, H.S., Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proceedings of the National Academy of Sciences of the United States of America 95 (1998), 5372–5377.
7. Benet-Pages, A., Orlik, P., Strom, T.M., Lorenz-Depiereux, B., An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Human Molecular Genetics 14 (2005), 385–390.
8. Borowitz, D., CFTR, bicarbonate, and the pathophysiology of cystic fibrosis. Pediatric Pulmonology 50 (2015), S24–S30.
9. Boucher, R.C., Evidence for airway surface dehydration as the initiating event in CF airway disease. Journal of Internal Medicine 261 (2007), 5–16.
10. Cardone, R.A., Bellizzi, A., Busco, G., Weinman, E.J., Dell'Aquila, M.E., Casavola, V., et al. The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells. Molecular Biology of the Cell 18 (2007), 1768–1780.
11. Christov, M., Jüppner, H., Insights from genetic disorders of phosphate homeostasis. Seminars in Nephrology 33 (2013), 143–157.
12. Cinar, A., Chen, M., Riederer, B., Bachmann, O., Wiemann, M., Manns, M., et al. NHE3 inhibition by cAMP and Ca2 + is abolished in PDZ-domain protein PDZK1-deficient murine enterocytes. Journal of Physiology (London) 581 (2007), 1235–1246.
13. Clarke, L.L., Harline, M.C., CFTR is required for cAMP inhibition of intestinal Na + absorption in a cystic fibrosis mouse model. The American Journal of Physiology 270 (1996), G259–G267.
14. Courbebaisse, M., Leroy, C., Bakouh, N., Salaün, C., Beck, L., Grandchamp, B., et al. A new human NHERF1 mutation decreases renal phosphate transporter NPT2a expression by a PTH-independent mechanism. PLoS One, 7, 2012, e34764.
15. Cunningham, R., Esmaili, A., Brown, E., Biswas, R.S., Murtazina, R., Donowitz, M., et al. Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice. American Journal of Physiology. Renal Physiology 294 (2008), F1001–F1007.
16. Cunningham, R., Steplock, D., Xiaofei, E., Biswas, R.S., Wang, F., Shenolikar, S., et al. Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone. American Journal of Physiology. Renal Physiology 291 (2006), F896–F901.
17. Dransfield, D.T., Bradford, A.J., Smith, J., Martin, M., Roy, C., Mangeat, P.H., et al. Ezrin is a cyclic AMP-dependent protein kinase anchoring protein. The EMBO Journal 16 (1997), 35–43.
18. Du, G., Gu, Y., Hao, C., Yuan, Z., He, J., Jiang, W.G., et al. The cellular distribution of Na +/H + exchanger regulatory factor 1 is determined by the PDZ-I domain and regulates the malignant progression of breast cancer. Oncotarget 7 (2016), 29440–29453.
19. Dunn, H.A., Ferguson, S.S., PDZ protein regulation of G protein-coupled receptor trafficking and signaling pathways. Molecular Pharmacology 88 (2015), 624–639.
20. Elborn, J.S., Cystic fibrosis. The Lancet 388 (2016), 2519–2531.
21. Fam, S.R., Paquet, M., Castleberry, A.M., Oller, H., Lee, C.J., Traynelis, S.F., et al. P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2. Proceedings of the National Academy of Sciences of the United States of America 102 (2005), 8042–8047.
22. Field, M., Intestinal electrolyte secretion. History of a paradigm. Archives of Surgery 128 (1993), 273–278.
23. Fukuoka, Y., Xia, H.-Z., Sanchez-Munoz, L.B., Dellinger, A.L., Escribano, L., Schwartz, L.B., Generation of anaphylatoxins by human beta-tryptase from C3, C4, and C5. Journal of Immunology 180 (2008), 6307–6316.
24. Garnett, J.P., Hickman, E., Burrows, R., Hegyi, P., Tiszlavicz, L., Cuthbert, A.W., et al. Novel role for pendrin in orchestrating bicarbonate secretion in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing airway serous cells. Journal of Biological Chemistry 286 (2011), 41069–41082.
25. Georgescu, M.M., Gagea, M., Cote, G., NHERF1/EBP50 suppresses Wnt-β-catenin pathway-driven intestinal neoplasia. Neoplasia 18 (2016), 512–523.
26. Georgescu, M.M., Morales, F.C., Molina, J.R., Hayashi, Y., Roles of NHERF1/EBP50 in cancer. Current Molecular Medicine 8 (2008), 459–468.
27. Gisler, S.M., Stagljar, I., Traebert, M., Bacic, D., Biber, J., Murer, H., Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. The Journal of Biological Chemistry 276 (2001), 9206–9213.
28. Greenwald, I., Gross, J., The effect of the administration of a potent parathyroid extract upon the excretion of nitrogen, phosphorus, calcium, and magnesium, with some remarks on the solubility of calcium phosphate in serum and on the pathogenesis of tetany. Journal of Biological Chemistry 66 (1925), 217–227.
29. Guerra, L., Favia, M., Fanelli, T., Calamita, G., Svetlo, M., Bagorda, A., et al. Stimulation of Xenopus P2Y1 receptor activates CFTR in A6 cells. Pflügers Archiv 449 (2004), 66–75.
30. Hall, R.A., Ostedgaard, L.S., Premont, R.T., Blitzer, J.T., Rahman, N., Welsh, M.J., et al. A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na +/H + exchanger regulatory factor family of PDZ proteins. Proceedings of the National Academy of Sciences of the United States of America 95 (1998), 8496–8501.
31. Hanahan, D., Weinberg, R.A., Hallmarks of cancer: The next generation. Cell 144 (2011), 646–674.
32. Harris, B.Z., Lim, W.A., Mechanism and role of PDZ domains in signaling complex assembly. Journal of Cell Science 114 (2001), 3219–3231.
33. Hayashi, Y., Molina, J.R., Hamilton, S.R., Georgescu, M.-M., NHERF1/EBP50 is a new marker in colorectal cancer. Neoplasia 12 (2010), 1013–1022.
34. Heldin, C.H., Westermark, B., Mechanism of action and in vivo role of platelet-derived growth factor. Physiological Reviews 79 (1999), 1283–1316.
35. Hernando, N., Forgo, J., Biber, J., Murer, H., PTH-induced downregulation of the type IIa Na/P-i-cotransporter is independent of known endocytic motifs. Journal of the American Society of Nephrology 11 (2000), 1961–1968.
36. Hillier, B.J., Christopherson, K.S., Prehoda, K.E., Bredt, D.S., Lim, W.A., Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science 284 (1999), 812–815.
37. Holcomb, J., Jiang, Y., Lu, G., Trescott, L., Brunzelle, J., Sirinupong, N., et al. Structural insights into PDZ-mediated interaction of NHERF2 and LPA(2), a cellular event implicated in CFTR channel regulation. Biochemical and Biophysical Research Communications 446 (2014), 399–403.
38. Hwang, J.I., Heo, K., Shin, K.J., Kim, E., Yun, C.H.C., Ryu, S.H., et al. Regulation of phospholipase C-beta 3 activity by Na +/H + exchanger regulatory factor 2. Journal of Biological Chemistry 275 (2000), 16632–16637.
39. Jarnaess, E., Ruppelt, A., Stokka, A.J., Lygren, B., Scott, J.D., Tasken, K., Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I. Journal of Biological Chemistry 283 (2008), 33708–33718.
40. Karim, Z., Gérard, B., Bakouh, N., Alili, R., Leroy, C., Beck, L., et al. NHERF1 mutations and responsiveness of renal parathyroid hormone. The New England Journal of Medicine 359 (2008), 1128–1135.
41. Kaufmann, M., Muff, R., Stieger, B., Biber, J., Murer, H., Fischer, J.A., Apical and basolateral parathyroid hormone receptors in rat renal cortical membranes. Endocrinology 134 (1994), 1173–1178.
42. Keely, S.J., Barrett, K.E., Regulation of chloride secretion. Novel pathways and messengers. Annals of the New York Academy of Sciences 915 (2000), 67–76.
43. Kere, J., Lohi, H., Höglund, P., Genetic disorders of membrane transport III. Congenital chloride diarrhea. The American Journal of Physiology 276 (1999), G7–G13.
44. Kim, J.K., Kwon, O., Kim, J., Kim, E.K., Park, H.K., Lee, J.E., et al. PDZ domain-containing 1 (PDZK1) protein regulates phospholipase C-β3 (PLC-β3)-specific activation of somatostatin by forming a ternary complex with PLC-β3 and somatostatin receptors. The Journal of Biological Chemistry 287 (2012), 21012–21024.
45. Kim, D., Liao, J., Hanrahan, J.W., The buffer capacity of airway epithelial secretions. Frontiers in Physiology, 5, 2014, 188.
46. Kim, E.J., Sheng, M., PDZ domain proteins of synapses. Nature Reviews Neuroscience 5 (2004), 771–781.
47. Ko, S.B., Shcheynikov, N., Choi, J.Y., Luo, X., Ishibashi, K., Thomas, P.J., et al. A molecular mechanism for aberrant CFTR-dependent HCO(3)(−) transport in cystic fibrosis. The EMBO Journal 21 (2002), 5662–5672.
48. Ko, S.B., Zeng, W., Dorwart, M.R., Luo, X., Kim, K.H., Millen, L., et al. Gating of CFTR by the STAS domain of SLC26 transporters. Nature Cell Biology 6 (2004), 343–350.
49. Kreimann, E.L., Morales, F.C., de Orbeta-Cruz, J., Takahashi, Y., Adams, H., Liu, T.J., et al. Cortical stabilization of beta-catenin contributes to NHERF1/EBP50 tumor suppressor function. Oncogene 26 (2007), 5290–5299.
50. Lamprecht, G., Seidler, U., The emerging role of PDZ adapter proteins for regulation of intestinal ion transport. American Journal of Physiology. Gastrointestinal and Liver Physiology 291 (2006), G766–G777.
51. − exchange in mouse submandibular and pancreatic ducts. The Journal of Biological Chemistry 274 (1999), 14670–14677.
52. Lee, J.H., Nam, J.H., Park, J., Kang, D.W., Kim, J.Y., Lee, M.G., et al. Regulation of SLC26A3 activity by NHERF4 PDZ-mediated interaction. Cellular Signalling 24 (2012), 1821–1830.
53. − exchange by cystic fibrosis transmembrane conductance regulator expressed in NIH 3T3 and HEK 293 cells. The Journal of Biological Chemistry 274 (1999), 3414–3421.
54. Lee, H.J., Zheng, J.J., PDZ domains and their binding partners: Structure, specificity, and modification. Cell Communication and Signaling: CCS, 8, 2010, 8.
55. + exchanger regulatory factor and the cystic fibrosis transmembrane conductance regulator. The Journal of Biological Chemistry 280 (2005), 37634–37643.
56. Li, C.Y., Naren, A.P., CFTR chloride channel in the apical compartments: Spatiotemporal coupling to its interacting partners. Integrative Biology 2 (2010), 161–177.
57. Li, C., Roy, K., Dandridge, K., Naren, A.P., Molecular assembly of cystic fibrosis transmembrane conductance regulator in plasma membrane. The Journal of Biological Chemistry 279 (2004), 24673–24684.
58. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S.I., et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275 (1997), 1943–1947.
59. Lim, H., Jou, T.-S., Ras-activated RSK1 phosphorylates EBP50 to regulate its nuclear localization and promote cell proliferation. Oncotarget 7 (2016), 10283–10296.
60. Lin, Y.Y., Hsu, Y.H., Huang, H.Y., Shann, Y.J., Huang, C.Y., Wei, S.C., et al. Aberrant nuclear localization of EBP50 promotes colorectal carcinogenesis in xenotransplanted mice by modulating TCF-1 and β-catenin interactions. The Journal of Clinical Investigation 122 (2012), 1881–1894.
61. Lundstrom, K., An overview on GPCRs and drug discovery: Structure-based drug design and structural biology on GPCRs. Methods in Molecular Biology 552 (2009), 51–66.
62. Maehama, T., Dixon, J.E., The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. Journal of Biological Chemistry 273 (1998), 13375–13378.
63. Magagnin, S., Werner, A., Markovich, D., Sorribas, V., Stange, G., Biber, J., et al. Expression cloning of human and rat renal cortex Na/Pi cotransport. Proceedings of the National Academy of Sciences of the United States of America 90 (1993), 5979–5983.
64. + exchanger-regulatory factor 1 mediates inhibition of phosphate transport by parathyroid hormone and second messengers by acting at multiple sites in opossum kidney cells. Molecular Endocrinology 17 (2003), 2355–2364.
65. Mangia, A., Chiriatti, A., Bellizzi, A., Malfettone, A., Stea, B., Zito, F.A., et al. Biological role of NHERF1 protein expression in breast cancer. Histopathology 55 (2009), 600–608.
66. Mickle, J.E., Macek, M., Fulmer-Smentek, S.B., Egan, M.M., Schwiebert, E., Guggino, W., et al. A mutation in the cystic fibrosis transmembrane conductance regulator gene associated with elevated sweat chloride concentrations in the absence of cystic fibrosis. Human Molecular Genetics 7 (1998), 729–735.
67. Molina, J.R., Morales, F.C., Hayashi, Y., Aldape, K.D., Georgescu, M.-M., Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation. Cancer Research 70 (2010), 6697–6703.
68. Mosenden, R., Tasken, K., Cyclic AMP-mediated immune regulation—Overview of mechanisms of action in T cells. Cellular Signalling 23 (2011), 1009–1016.
69. Moyer, B.D., Denton, J., Karlson, K.H., Reynolds, D., Wang, S., Mickle, J.E., et al. A PDZ-interacting domain in CFTR is an apical membrane polarization signal. The Journal of Clinical Investigation 104 (1999), 1353–1361.
70. Murer, H., Biber, J., Phosphate transport in the kidney. Journal of Nephrology 23:Suppl. 16 (2010), S145–S151.
71. Murer, H., Hernando, N., Forster, I., Biber, J., Proximal tubular phosphate reabsorption: Molecular mechanisms. Physiological Reviews 80 (2000), 1373–1409.
72. Murtazina, R., Kovbasnjuk, O., Chen, T.-E., Zachos, N.C., Chen, Y., Kocinsky, H.S., et al. NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum. American Journal of Physiology-Cell Physiology 301 (2011), C126–C136.
73. Musgrove, E.A., Caldon, C.E., Barraclough, J., Stone, A., Sutherland, R.L., Cyclin D as a therapeutic target in cancer. Nature Reviews. Cancer 11 (2011), 558–572.
74. Naren, A.P., Cobb, B., Li, C., Roy, K., Nelson, D., Heda, G.D., et al. A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA. Proceedings of the National Academy of Sciences of the United States of America 100 (2003), 342–346.
75. Oh, Y.S., Jo, N.W., Choi, J.W., Kim, H.S., Seo, S.W., Kang, K.O., et al. NHERF2 specifically interacts with LPA(2) receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta 3 activation. Molecular and Cellular Biology 24 (2004), 5069–5079.
76. Orsetti, B., Courjal, F., Cuny, M., Rodriguez, C., Theillet, C., 17q21-q25 aberrations in breast cancer: Combined allelotyping and CGH analysis reveals 5 regions of allelic imbalance among which two correspond to DNA amplification. Oncogene 18 (1999), 6262–6270.
77. Pages, C., Simon, M.F., Valet, P., Saulnier-Blache, J.S., Lysophosphatidic acid synthesis and release. Prostaglandins & Other Lipid Mediators 64 (2001), 1–10.
78. Pan, Y., Weinman, E.J., Dai, J.L., Na(+)/H(+) exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells. Breast Cancer Research, 10, 2008, R5.
79. Paul, I., Bhattacharya, S., Chatterjee, A., Ghosh, M.K., Current understanding on EGFR and Wnt/β-catenin signaling in glioma and their possible crosstalk. Genes & Cancer 4 (2013), 427–446.
80. Pezzulo, A.A., Tang, X.X., Hoegger, M.J., Abou Alaiwa, M.H., Ramachandran, S., Moninger, T.O., et al. Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature 487 (2012), 109–113.
81. Picotto, G., Massheimer, V., Boland, R., Parathyroid hormone stimulates calcium influx and the cAMP messenger system in rat enterocytes. The American Journal of Physiology 273 (1997), C1349–C1353.
82. Plummer, S.J., Adams, L., Simmons, J.A., Casey, G., Localization of a growth suppressor activity in MCF7 breast cancer cells to chromosome 17q24-q25. Oncogene 14 (1997), 2339–2345.
83. Presneau, N., Dewar, K., Forgetta, V., Provencher, D., Mes-Masson, A.M., Tonin, P.N., Loss of heterozygosity and transcriptome analyses of a 1.2 Mb candidate ovarian cancer tumor suppressor locus region at 17q25.1-q25.2. Molecular Carcinogenesis 43 (2005), 141–154.
84. Raghuram, V., Hormuth, H., Foskett, J.K., A kinase-regulated mechanism controls CFTR channel gating by disrupting bivalent PDZ domain interactions. Proceedings of the National Academy of Sciences of the United States of America 100 (2003), 9620–9625.
85. Ralevic, V., Burnstock, G., Receptors for purines and pyrimidines. Pharmacological Reviews 50 (1998), 413–492.
86. Ruppelt, A., Mosenden, R., Groenholm, M., Aandahl, E.M., Tobin, D., Carlson, C.R., et al. Inhibition of T cell activation by cyclic adenosine 5′-monophosphate requires lipid raft targeting of protein kinase a type I by the A-kinase anchoring protein Ezrin. Journal of Immunology 179 (2007), 5159–5168.
87. Sarker, R., Valkhoff, V.E., Zachos, N.C., Lin, R., Cha, B., Chen, T.E., et al. NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity. American Journal of Physiology-Cell Physiology 300 (2011), C771–C782.
88. Schaefer, B., Piliponsky, A.M., Oka, T., Song, C.H., Gerard, N.P., Gerard, C., et al. Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice. Journal of Allergy and Clinical Immunology, 131, 2013, 541.
89. + exchanger. Nature Genetics 19 (1998), 282–285.
90. Seidler, U., Singh, A.K., Cinar, A., Chen, M.M., Hillesheim, J., Hogema, B., et al. The role of the NHERF family of PDZ scaffolding proteins in the regulation of salt and water transport lessons learned from knockout mice. Molecular Structure and Function of the Tight Junction: From Basic Mechanisms to Clinical Manifestations 1165 (2009), 249–260.
91. Sharma, N., LaRusch, J., Sosnay, P.R., Gottschalk, L.B., Lopez, A.P., Pellicore, M.J., et al. A sequence upstream of canonical PDZ-binding motif within CFTR COOH-terminus enhances NHERF1 interaction. American Journal of Physiology. Lung Cellular and Molecular Physiology 311 (2016), L1170–L1182.
92. Sheng, M., Sala, C., PDZ domains and the organization of supramolecular complexes. Annual Review of Neuroscience 24 (2001), 1–29.
93. Shenolikar, S., Voltz, J.W., Minkoff, C.M., Wade, J.B., Weinman, E.J., Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proceedings of the National Academy of Sciences of the United States of America 99 (2002), 11470–11475.
94. Singh, A.K., Riederer, B., Krabbenhöft, A., Rausch, B., Bonhagen, J., Lehmann, U., et al. Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. The Journal of Clinical Investigation 119 (2009), 540–550.
95. Songyang, Z., Fanning, A.S., Fu, C., Xu, J., Marfatia, S.M., Chishti, A.H., et al. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 275 (1997), 73–77.
96. Stokka, A.J., Mosenden, R., Ruppelt, A., Lygren, B., Tasken, K., The adaptor protein EBP50 is important for localization of the protein kinase A-Ezrin complex in T-cells and the immunomodulating effect of cAMP. Biochemical Journal 425 (2010), 381–388.
97. Subramanian, H., Gupta, K., Ali, H., Roles for NHERF1 and NHERF2 on the regulation of C3a receptor signaling in human mast cells. Plos One, 7, 2012, e51355.
98. Sun, L., Zhao, L., Du, L., Zhang, P., Zhang, M., Li, M., et al. Identification of two novel mutations in the GALNT3 gene in a Chinese family with hyperphosphatemic familial tumoral calcinosis. Bone Research, 4, 2016, 16038.
99. Swiatecka-Urban, A., Duhaime, M., Coutermarsh, B., Karlson, K.H., Collawn, J., Milewski, M., et al. PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulator. The Journal of Biological Chemistry 277 (2002), 40099–40105.
100. Takahashi, Y., Morales, F.C., Kreimann, E.L., Georgescu, M.M., PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. EMBO Journal 25 (2006), 910–920.
101. Taouil, K., Hinnrasky, J., Hologne, C., Corlieu, P., Klossek, J.M., Puchelle, E., Stimulation of beta 2-adrenergic receptor increases cystic fibrosis transmembrane conductance regulator expression in human airway epithelial cells through a cAMP/protein kinase A-independent pathway. The Journal of Biological Chemistry 278 (2003), 17320–17327.
102. Thelin, W.R., Hodson, C.A., Milgram, S.L., Beyond the brush border: NHERF4 blazes new NHERF turf. The Journal of Physiology 567 (2005), 13–19.
103. Thiagarajah, J.R., Verkman, A.S., CFTR pharmacology and its role in intestinal fluid secretion. Current Opinion in Pharmacology 3 (2003), 594–599.
104. Tian, X., Liu, Z., Niu, B., Zhang, J., Tan, T.K., Lee, S.R., et al. E-cadherin/beta-catenin complex and the epithelial barrier. Journal of Biomedicine & Biotechnology, 2011, 2011, 567305.
105. Tonikian, R., Zhang, Y., Sazinsky, S.L., Currell, B., Yeh, J.H., Reva, B., et al. A specificity map for the PDZ domain family. PLoS Biology, 6, 2008, e239.
106. Traebert, M., Völkl, H., Biber, J., Murer, H., Kaissling, B., Luminal and contraluminal action of 1-34 and 3-34 PTH peptides on renal type IIa Na-P(i) cotransporter. American Journal of Physiology. Renal Physiology 278 (2000), F792–F798.
107. Tröhler, U., Bonjour, J.P., Fleisch, H., Inorganic phosphate homeostasis. Renal adaptation to the dietary intake in intact and thyroparathyroidectomized rats. The Journal of Clinical Investigation 57 (1976), 264–273.
108. van der Doef, H.P., Kokke, F.T., Beek, F.J., Woestenenk, J.W., Froeling, S.P., Houwen, R.H., Constipation in pediatric cystic fibrosis patients: An underestimated medical condition. Journal of Cystic Fibrosis 9 (2010), 59–63.
109. Villa-Bellosta, R., Sorribas, V., Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis. Pflügers Archiv 459 (2010), 499–508.
110. Vogelstein, B., Kinzler, K.W., Cancer genes and the pathways they control. Nature Medicine 10 (2004), 789–799.
111. Wade, J.B., Liu, J., Coleman, R.A., Cunningham, R., Steplock, D.A., Lee-Kwon, W., et al. Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse. American Journal of Physiology. Cell Physiology 285 (2003), C1494–C1503.
112. Wade, J.B., Welling, P.A., Donowitz, M., Shenolikar, S., Weinman, E.J., Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK. American Journal of Physiology. Cell Physiology 280 (2001), C192–C198.
113. Wagner, C.A., Rubio-Aliaga, I., Biber, J., Hernando, N., Genetic diseases of renal phosphate handling. Nephrology, Dialysis, Transplantation 29:Suppl. 4 (2014), iv45–iv54.
114. Walker, L.C., Venglarik, C.J., Aubin, G., Weatherly, M.R., McCarty, N.A., Lesnick, B., et al. Relationship between airway ion transport and a mild pulmonary disease mutation in CFTR. American Journal of Respiratory and Critical Care Medicine 155 (1997), 1684–1689.
115. Walther, C., Caetano, F.A., Dunn, H.A., Ferguson, S.S., PDZK1/NHERF3 differentially regulates corticotropin-releasing factor receptor 1 and serotonin 2A receptor signaling and endocytosis. Cellular Signalling 27 (2015), 519–531.
116. Wang, B., Ardura, J.A., Romero, G., Yang, Y., Hall, R.A., Friedman, P.A., Na/H exchanger regulatory factors control parathyroid hormone receptor signaling by facilitating differential activation of G(alpha) protein subunits. The Journal of Biological Chemistry 285 (2010), 26976–26986.
117. Wang, B., Means, C.K., Yang, Y., Mamonova, T., Bisello, A., Altschuler, D.L., et al. Ezrin-anchored protein kinase A coordinates phosphorylation-dependent disassembly of a NHERF1 ternary complex to regulate hormone-sensitive phosphate transport. The Journal of Biological Chemistry 287 (2012), 24148–24163.
118. Wang, S., Yue, H., Derin, R.B., Guggino, W.B., Li, M., Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity. Cell 103 (2000), 169–179.
119. Weinman, E.J., Biswas, R.S., Peng, G., Peng, Q., Shen, L., Turner, C.L., et al. Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. The Journal of Clinical Investigation 117 (2007), 3412–3420.
120. Weinman, E.J., Steplock, D., Zhang, Y., Biswas, R., Bloch, R.J., Shenolikar, S., Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport. The Journal of Biological Chemistry 285 (2010), 25134–25138.
121. Werner, A., Moore, M.L., Mantei, N., Biber, J., Semenza, G., Murer, H., Cloning and expression of CDNA for a NA/PI cotransport system of kidney cortex. Proceedings of the National Academy of Sciences of the United States of America 88 (1991), 9608–9612.
122. + exchanger regulatory factor-1 in rat osteosarcoma ROS 17/2.8 cells. Molecular Endocrinology 22 (2008), 1163–1170.
123. Wolfer, A., Ramaswamy, S., MYC and metastasis. Cancer Research 71 (2011), 2034–2037.
124. Wu, Y., Zhou, B.P., New insights of epithelial-mesenchymal transition in cancer metastasis. Acta Biochimica et Biophysica Sinica 40 (2008), 643–650.
125. Yang, X., Du, G., Yu, Z., Si, Y., Martin, T.A., He, J., et al. A novel NHERF1 mutation in human breast cancer and effects on malignant progression. Anticancer Research 37 (2017), 67–73.
126. Yang, J., Singh, V., Chen, T.E., Sarker, R., Xiong, L., Cha, B., et al. NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol. Journal of Biological Chemistry 289 (2014), 20039–20053.
127. Yun, C.H., Oh, S., Zizak, M., Steplock, D., Tsao, S., Tse, C.M., et al. cAMP-mediated inhibition of the epithelial brush border Na +/H + exchanger, NHE3, requires an associated regulatory protein. Proceedings of the National Academy of Sciences of the United States of America 94 (1997), 3010–3015.
128. Yun, C.C., Sun, H., Wang, D., Rusovici, R., Castleberry, A., Hall, R.A., et al. LPA2 receptor mediates mitogenic signals in human colon cancer cells. American Journal of Physiology. Cell Physiology 289 (2005), C2–11.
129. Zachos, N.C., Li, X., Kovbasnjuk, O., Hogema, B., Sarker, R., Lee, L.J., et al. NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells. Journal of Biological Chemistry 284 (2009), 23708–23718.
130. Zachos, N.C., Li, X., Kovbasnjuk, O., Sarkar, R., Hogema, B., de Jonge, H., et al. Elevated intracellular calcium (Ca2 + i) inhibits NFIE3 activity by a PDZK1 (NHERF3) dependent process in which NHE3 and PDZK1 bind basally and dissociate with elevated Ca2 + i. Gastroenterology, 130, 2006, A51.