Aberrant nuclear localization of EBP50 promotes colorectal carcinogenesis in xenotransplanted mice by modulating TCF-1 and β-catenin interactions

Journal of Clinical Investigation

Volumn 122, Issue 5, 2012, Pages 1881-1894

  Lin, Yu Yu ^a,b   Hsu, Yung Ho ^c   Huang, Hsin Yi ^b   Shann, Yih Jyh ^d   Huang, Chi Ying F ^d   Wei, Shu Chen ^b   Chen, Chi Ling ^a   Jou, Tzuu Shuh ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIN D1; ERM BINDING PHOSPHOPROTEIN 50; PHOSPHOPROTEIN; TRANSCRIPTION FACTOR 7; UNCLASSIFIED DRUG; WNT PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SURVIVAL; CARCINOMA CELL; CELL CYCLE PROGRESSION; CELL DENSITY; CELL NUCLEUS; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; COLON CARCINOGENESIS; COLORECTAL CANCER; COLORECTAL CARCINOGENESIS; COMPLEX FORMATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; DISEASE SPECIFIC SURVIVAL; DNA RESPONSIVE ELEMENT; FEMALE; GENOME ANALYSIS; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE C MYC; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PDZ DOMAIN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ACTIVE TRANSPORT, CELL NUCLEUS; AGED; AGED, 80 AND OVER; ANIMALS; BASE SEQUENCE; BETA CATENIN; BINDING SITES; CARCINOMA; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICE; MICE, SCID; MIDDLE AGED; MULTIPROTEIN COMPLEXES; NEOPLASM TRANSPLANTATION; PDZ DOMAINS; PHOSPHOPROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER; T CELL TRANSCRIPTION FACTOR 1;

EID: 84860547619     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI45661     Document Type: Article

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