Structural insights into PDZ-mediated interaction of NHERF2 and LPA 2, a cellular event implicated in CFTR channel regulation

Biochemical and Biophysical Research Communications

Volumn 446, Issue 1, 2014, Pages 399-403

  Holcomb, Joshua ^a   Jiang, Yuanyuan ^a   Lu, Guorong ^a   Trescott, Laura ^a   Brunzelle, Joseph ^b   Sirinupong, Nualpun ^c   Li, Chunying ^a   Naren, Anjaparavanda P ^d   Yang, Zhe ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ARGONNE NATIONAL LABORATORY   (United States)

^c PRINCE OF SONGKLA UNIVERSITY   (Thailand)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

CFTR; Cystic fibrosis; NHERF2; Scaffold protein; X ray crystallography

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR 2; PDZ PROTEIN; PDZ PROTEIN NHERF2; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; HYDROGEN BOND; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION; REGULATORY MECHANISM;

CFTR; CYSTIC FIBROSIS; LPA(2); NHERF2; SCAFFOLD PROTEIN; X-RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DRUG DESIGN; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; PDZ DOMAINS; PHOSPHOPROTEINS; PROTEIN STRUCTURE, QUATERNARY; RECEPTORS, LYSOPHOSPHATIDIC ACID; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM-HYDROGEN ANTIPORTER; THIOCYANATES;

EID: 84898005707     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.02.128     Document Type: Article

References (32)

1. J.R. Riordan, J.M. Rommens, B. Kerem, N. Alon, R. Rozmahel, Z. Grzelczak, J. Zielenski, S. Lok, N. Plavsic, and J.L. Chou et al. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA Science 245 1989 1066 1073
2. M.P. Anderson, R.J. Gregory, S. Thompson, D.W. Souza, S. Paul, R.C. Mulligan, A.E. Smith, and M.J. Welsh Demonstration that CFTR is a chloride channel by alteration of its anion selectivity Science 253 1991 202 205
3. S.T. Ballard, and D. Spadafora Fluid secretion by submucosal glands of the tracheobronchial airways Respir. Physiol. Neurobiol. 159 2007 271 277
4. J.R. Riordan CFTR function and prospects for therapy Annu. Rev. Biochem. 77 2008 701 726
5. C. Li, and A.P. Naren Macromolecular complexes of cystic fibrosis transmembrane conductance regulator and its interacting partners Pharmacol. Ther. 108 2005 208 223
6. C. Li, and A.P. Naren CFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partners Integr. Biol. (Camb) 2 2010 161 177
7. A.P. Naren, B. Cobb, C. Li, K. Roy, D. Nelson, G.D. Heda, J. Liao, K.L. Kirk, E.J. Sorscher, J. Hanrahan, and J.P. Clancy A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA Proc. Natl. Acad. Sci. USA 100 2003 342 346
8. H. Penmatsa, W. Zhang, S. Yarlagadda, C. Li, V.G. Conoley, J. Yue, S.W. Bahouth, R.K. Buddington, G. Zhang, D.J. Nelson, M.D. Sonecha, V. Manganiello, J.J. Wine, and A.P. Naren Compartmentalized cyclic adenosine 3′,5′-monophosphate at the plasma membrane clusters PDE3A and cystic fibrosis transmembrane conductance regulator into microdomains Mol. Biol. Cell 21 2010 1097 1110
9. C. Li, K.S. Dandridge, A. Di, K.L. Marrs, E.L. Harris, K. Roy, J.S. Jackson, N.V. Makarova, Y. Fujiwara, P.L. Farrar, D.J. Nelson, G.J. Tigyi, and A.P. Naren Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions J. Exp. Med. 202 2005 975 986
10. F.T. Lin, and Y.J. Lai Regulation of the LPA2 receptor signaling through the carboxyl-terminal tail-mediated protein-protein interactions Biochim. Biophys. Acta 1781 2008 558 562
11. S. Shenolikar, and E.J. Weinman NHERF: targeting and trafficking membrane proteins Am. J. Physiol. Renal Physiol. 280 2001 F389 F395
12. W. Zhang, H. Penmatsa, A. Ren, C. Punchihewa, A. Lemoff, B. Yan, N. Fujii, and A.P. Naren Functional regulation of cystic fibrosis transmembrane conductance regulator-containing macromolecular complexes: a small-molecule inhibitor approach Biochem. J. 435 2011 451 462
13. B.Z. Harris, and W.A. Lim Mechanism and role of PDZ domains in signaling complex assembly J. Cell Sci. 114 2001 3219 3231
14. M. Sheng, and C. Sala PDZ domains and the organization of supramolecular complexes Annu. Rev. Neurosci. 24 2001 1 29
15. H.J. Lee, and J.J. Zheng PDZ domains and their binding partners: structure, specificity, and modification Cell Commun. Signal. 8 2010 8
16. S. Karthikeyan, T. Leung, and J.A. Ladias Structural basis of the Na+/H+ exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulator J. Biol. Chem. 276 2001 19683 19686
17. R. Tonikian, Y. Zhang, S.L. Sazinsky, B. Currell, J.H. Yeh, B. Reva, H.A. Held, B.A. Appleton, M. Evangelista, Y. Wu, X. Xin, A.C. Chan, S. Seshagiri, L.A. Lasky, C. Sander, C. Boone, G.D. Bader, and S.S. Sidhu A specificity map for the PDZ domain family PLoS Biol. 6 2008 e239
18. W. Kabsch Xds Acta Crystallogr. D Biol. Crystallogr. 66 2010 125 132
19. A.J. McCoy, R.W. Grosse-Kunstleve, P.D. Adams, M.D. Winn, L.C. Storoni, and R.J. Read Phaser crystallographic software J. Appl. Crystallogr. 40 2007 658 674
20. P. Emsley, and K. Cowtan Coot: model-building tools for molecular graphics Acta Crystallogr. D Biol. Crystallogr. 60 2004 2126 2132
21. P.D. Adams, P.V. Afonine, G. Bunkoczi, V.B. Chen, I.W. Davis, N. Echols, J.J. Headd, L.W. Hung, G.J. Kapral, R.W. Grosse-Kunstleve, A.J. McCoy, N.W. Moriarty, R. Oeffner, R.J. Read, D.C. Richardson, J.S. Richardson, T.C. Terwilliger, and P.H. Zwart PHENIX: a comprehensive Python-based system for macromolecular structure solution Acta Crystallogr. D Biol. Crystallogr. 66 2010 213 221
22. V.B. Chen, W.B. Arendall 3rd, J.J. Headd, D.A. Keedy, R.M. Immormino, G.J. Kapral, L.W. Murray, J.S. Richardson, and D.C. Richardson MolProbity: all-atom structure validation for macromolecular crystallography Acta Crystallogr. D Biol. Crystallogr. 66 2010 12 21
23. S.T. Runyon, Y. Zhang, B.A. Appleton, S.L. Sazinsky, P. Wu, B. Pan, C. Wiesmann, N.J. Skelton, and S.S. Sidhu Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3 Protein Sci. 16 2007 2454 2471
24. S. Karthikeyan, T. Leung, and J.A. Ladias Structural determinants of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors J. Biol. Chem. 277 2002 18973 18978
25. W. Zhang, N. Fujii, and A.P. Naren Recent advances and new perspectives in targeting CFTR for therapy of cystic fibrosis and enterotoxin-induced secretory diarrheas Future Med. Chem. 4 2012 329 345
26. L. Thevenet, K.H. Albrecht, S. Malki, P. Berta, B. Boizet-Bonhoure, and F. Poulat NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY J. Biol. Chem. 280 2005 38625 38630
27. Y.S. Oh, N.W. Jo, J.W. Choi, H.S. Kim, S.W. Seo, K.O. Kang, J.I. Hwang, K. Heo, S.H. Kim, Y.H. Kim, I.H. Kim, J.H. Kim, Y. Banno, S.H. Ryu, and P.G. Suh NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation Mol. Cell. Biol. 24 2004 5069 5079
28. P. He, S.J. Lee, S. Lin, U. Seidler, F. Lang, G. Fejes-Toth, A. Naray-Fejes-Toth, and C.C. Yun Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids Mol. Biol. Cell 22 2011 3812 3825
29. R. Padanyi, Y. Xiong, G. Antalffy, K. Lor, K. Paszty, E.E. Strehler, and A. Enyedi Apical scaffolding protein NHERF2 modulates the localization of alternatively spliced plasma membrane Ca2+ pump 2B variants in polarized epithelial cells J. Biol. Chem. 285 2010 31704 31712
30. G. Lu, Y. Wu, Y. Jiang, S. Wang, Y. Hou, X. Guan, J. Brunzelle, N. Sirinupong, S. Sheng, C. Li, and Z. Yang Structural insights into neutrophilic migration revealed by the crystal structure of the chemokine receptor CXCR2 in complex with the first PDZ domain of NHERF1 PLoS ONE 8 2013 e76219
31. Y. Jiang, G. Lu, L.R. Trescott, Y. Hou, X. Guan, S. Wang, A. Stamenkovich, J. Brunzelle, N. Sirinupong, C. Li, and Z. Yang New conformational state of NHERF1-CXCR2 signaling complex captured by crystal lattice trapping PLoS ONE 8 2013 e81904
32. M.A. Larkin, G. Blackshields, N.P. Brown, R. Chenna, P.A. McGettigan, H. McWilliam, F. Valentin, I.M. Wallace, A. Wilm, R. Lopez, J.D. Thompson, T.J. Gibson, and D.G. Higgins Clustal W and Clustal X version 2.0 Bioinformatics 23 2007 2947 2948