PTH-induced downregulation of the type IIa Na/P(i)-cotransporter is independent of known endocytic motifs

Journal of the American Society of Nephrology

Volumn 11, Issue 11, 2000, Pages 1961-1968

  Hernando, N ^a   Forgo, J ^a   Biber, J ^a   Murer, H ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; LEUCINE; PARATHYROID HORMONE; PHOSPHATE; SODIUM ION; TYROSINE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; ENDOCYTOSIS; INTERNALIZATION; ION TRANSPORT; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; LYSOSOME; MUTATION; NONHUMAN; OPOSSUM; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0033761067     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. A molecular view of proximal tubular inorganic phosphate (P(i)) reabsorption and its regulation
2. Expression of Na-P(i) cotransport in rat kidney: Localization by RT-PCR and immunohistochemistry
3. Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities
4. Parathyroid hormone action on phosphate transporter mRNA and protein in rat renal proximal tubules
5. +/P(i) cotransporters
6. Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/P(i) cotransporter
7. Parathyroid hormone and dietary phosphate provoke lysosomal routing of the proximal tubular Na/P(i)-cotransporter type II
8. Internalization of proximal tubular type II Na/P(i)-cotransporter by parathyroid hormone: An immunogold electron microscopy study
9. Endocytosis and molecular sorting
10. A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MCH class II compartments
11. Nef-induced CD4 degradation: A diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding to b-COP in endosomes
12. The J.D. mutation in familial hypercholesterolemia: Amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors
13. Accumulation of membrane glycoproteins in lysosomes requires a tyrosine residue at a particular position in the cytoplasmic tail
14. Transport of the lysosomal membrane glycoprotein lgp 120 (lgp-A) to lysosomes does not require appearance on the plasma membrane
15. Structural requirements and sequence motifs for polarized sorting and endocytosis of LDL and Fc receptors in MDCK cells
16. A tyrosine-based signal targets H/K-ATPase to a regulated compartment and is required for the cessation of gastric acid secretion
17. A structural explanation for the recognition of tyrosine-based endocytic signals
18. The targeting of Lamp 1 to lysosomes is dependent on the spacing of its cytoplasmic tall tyrosine sorting motif relative to the membrane
19. A His-Leu-Leu sequence near the carboxyl terminus of the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor is necessary for the lysosomal enzyme sorting function
20. A novel di-leucine motif and a tyrosine based motif independently mediate lysosomal targeting and endocytosis of CD3 chains
21. Dileucine-based sorting signals bind to the β chain of the AP-1 at a site distinct and regulated differently from the tyrosine-based motif-bind site
22. A dileucine-like sorting signal directs transport into an AP3-dependent, clathrin-independent pathway to the yeast vacuole
23. Interaction of tyrosine-based sorting signals with clathrin-associated proteins
24. Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes
25. Protein targeting by tyrosine and di-leucine-based signals: Evidence for distinct saturable components
26. AP-3: An adaptor-like protein complex with ubiquitous expression
27. Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes
28. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP2
29. In vitro binding of clathrin adaptors to sorting signals correlates with endocytosis and basolateral sorting
30. Cytotoxic T-lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail
31. Expression cloning of human and rat renal cortex Na/P(i) cotransport
32. Studies on the topology of the renal type II NaPi-cotransporter
33. +/P(i)-cotransporter expressed in oocytes
34. Expression of renal transport systems for inorganic phosphate and sulfate in Xenopus laevis oocytes
35. Functional asymmetry in phosphate transport and its regulation in opossum kidney cells: Parathyroid hormone inhibition
36. Rapid downregulation of rat renal Na/P(i) cotransporter in response to parathyroid hormone involves microtubule rearrangement
37. A Leu-Leu sequence is essential for COOH-terminal targeting signal of GLUT4 glucose transporter in fibroblast
38. A double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal
39. Efficient endocytosis of the cystic fibrosis transmembrane conductance regulator requires a tyrosine-based signal