A kinase-regulated mechanism controls CFTR channel gating by disrupting bivalent PDZ domain interactions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 16, 2003, Pages 9620-9625

  Raghuram, Viswanathan ^a   Hormuth, Hayley ^a   Foskett, J Kevin ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CHLORIDE CHANNEL; POLYPROTEIN; PROTEIN KINASE C; PROTEIN NHERF; PROTEIN PDZ1; PROTEIN PDZ2; PROTEIN ZO1; REGULATOR PROTEIN; SERINE; SODIUM PROTON EXCHANGE PROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CHANNEL GATING; CYSTIC FIBROSIS; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE MUTATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROBABILITY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; ASPARTIC ACID; CHO CELLS; CRICETINAE; CROSS-LINKING REAGENTS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; EPITOPES; HUMANS; IONS; MOLECULAR SEQUENCE DATA; MUTATION; NERVE TISSUE PROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER;

ANIMALIA;

EID: 0041421190     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1633250100     Document Type: Article

References (38)

1. Sheppard, D. N. & Welsh, M. J. (1999) Physiol. Rev. 79, S23-S45.
2. Jia, Y., Mathews, C. J. & Hanrahan, J. W. (1997) J. Biol. Chem. 272, 4978-4984.
3. Wang, S., Raab, R. W., Schatz, P. J., Guggino, W. B. & Li, M. (1998) FEBS Lett. 427, 103-108.
4. Short, D. B., Trotter, K. W., Reczek, D., Kreda, S. M., Bretscher, A., Boucher, R. C., Stutts, M. J. & Milgram, S. L. (1998) J. Biol. Chem. 273, 19797-19801.
5. Hall, R. A., Ostedgaard, L. S., Premont, R. T., Blitzer, J. T., Rahman, N., Welsh, M. J. & Lefkowitz, R. J. (1998) Proc. Natl. Acad. Sci. USA 95, 8496-8501.
6. Wang, S., Yue, H., Derin, R. B., Guggino, W. B. & Li, M. (2000) Cell 103, 169-179.
7. Cheng, J., Moyer, B. D., Milewski, M., Loffing, J., Ikeda, M., Mickle, J. E., Cutting, G. R., Li, M., Stanton, B. A. & Guggino, W. B. (2002) J. Biol. Chem. 277, 3520-3529.
8. Moyer, B. D., Duhaime, M., Shaw, C., Denton, J., Reynolds, D., Karlson, K. H., Pfeiffer, J., Wang, S., Mickle, J. E., Milewski, M., et al. (2000) J. Biol. Chem. 275, 27069-27074.
9. Swiatecka-Urban, A., Duhaime, M., Coutermarsh, B., Karlson, K. H., Collawn, J., Milewski, M., Cutting, G. R., Guggino, W. B., Langford, G. & Stanton, B. A. (2002) J. Biol. Chem. 277, 40099-40105.
10. Raghuram, V., Mak, D. D. & Foskett, J. K. (2001) Proc. Natl. Acad. Sci. USA 98, 1300-1305.
11. Chung, H. J., Xia, J., Scannevin, R. H., Zhang, X. & Huganir, R. L. (2000) J. Neurosci. 20, 7258-7267.
12. Cohen, N. A., Brenman, J. E., Snyder, S. H. & Bredt, D. S. (1996) Neuron 17, 759-767.
13. Cao, T. T., Deacon, H. W., Reczek, D., Bretscher, A. & von Zastrow, M. (1999) Nature 401, 286-290.
14. Kim, C. H., Chung, H. J., Lee, H. K. & Huganir, R. L. (2001) Proc. Natl. Acad. Sci. USA 98, 11725-11730.
15. Hayashi, Y., Shi, S. H., Esteban, J. A., Piccini, A., Poncer, J. C. & Malinow, R. (2000) Science 287, 2262-2267.
16. Lansdell, K. A., Kidd, J. F., Delaney, S. J., Wainwright, B. J. & Sheppard, D. N. (1998) J. Physiol. (London) 512, 751-764.
17. Dirr, H., Reinemer, P. & Huber, R. (1994) Eur. J. Biochem. 230, 614-620.
18. Armstrong, R. N. (1997) Chem. Res. Toxicol. 10, 2-18.
19. Tudyka, T. & Skerra, A. (1997) Protein Sci. 6, 2180-2187.
20. Blom, N., Gammeltoft, S. & Brunak, S. (1999) J. Mol. Biol. 294, 1351-1362.
21. Lau, A. G. & Hall, R. A. (2001) Biochemistry 40, 8572-8580.
22. Hall, R. A., Spurney, R. F., Premont, R. T., Rahman, N., Blitzer, J. T., Pitcher, J. A. & Lefkowitz, R. J. (1999) J. Biol. Chem. 274, 24328-24334.
23. Fouassier, L., Yun, C. C., Fitz, J. G. & Doctor, R. B. (2000) J. Biol. Chem. 275, 25039-25045.
24. Maudsley, S., Zamah, A. M., Rahman, N., Blitzer, J. T., Luttrell, L. M., Lefkowitz, R. J. & Hall, R. A. (2000) Mol. Cell. Biol. 20, 8352-8363.
25. Shenolikar, S., Minkoff, C. M., Steplock, D. A., Evangelista, C., Liu, M. & Weinman, E. J. (2001) FEBS Lett. 489, 233-236.
26. Sheng, M. & Sala, C. (2001) Annu. Rev. Neurosci. 24, 1-29.
27. Yun, C. H., Oh, S., Zizak, M., Steplock, D., Tsao, S., Tse, C. M., Weinman, E. J. & Donowitz, M. (1997) Proc. Natl. Acad. Sci. USA 94, 3010-3015.
28. Mohler, P. J., Kreda, S. M., Boucher, R. C., Sudol, M., Stutts, M. J. & Milgram, S. L. (1999) J. Cell Biol. 147, 879-890.
29. Hwang, J. I., Heo, K., Shin, K. J., Kim, E., Yun, C., Ryu, S. H., Shin, H. S. & Suh, P. G. (2000) J. Biol. Chem. 275, 16632-16637.
30. Gisler, S. M., Stagljar, I., Traebert, M., Bacic, D., Biber, J. & Murer, H. (2001) J. Biol. Chem. 276, 9206-9213.
31. Mahon, M. J., Donowitz, M., Yun, C. C. & Segre, G. V. (2002) Nature 417, 858-861.
32. Liedtke, C. M., Yun, C. H., Kyle, N. & Wang, D. (2002) J. Biol. Chem. 277, 22925-22933.
33. Welsh, M. J. (1987) Am. J. Physiol. 253, C828-C834.
34. Barthelson, R. A., Jacoby, D. B. & Widdicombe, J. H. (1987) Am. J. Physiol. 253, C802-C808.
35. Breuer, W., Glickstein, H., Kartner, N., Riordan, J. R., Ausiello, D. A. & Cabantchik, I. Z. (1993) J. Biol. Chem. 268, 13935-13939.
36. Karthikeyan, S., Leung, T. & Ladias, J. A. (2001) J. Biol. Chem. 276, 19683-19686.
37. Karthikeyan, S., Leung, T. & Ladias, J. A. (2002) J. Biol. Chem. 277, 18973-18978.
38. Yoshimura, Y., Aoi, C. & Yamauchi, T. (2000) Brain Res. 81, 118-128.