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Volumn 108, Issue , 2017, Pages 457-471

Nrf2 pathway activation upon rotenone treatment in human iPSC-derived neural stem cells undergoing differentiation towards neurons and astrocytes

Author keywords

Astrocyte; Dopaminergic neurons; Neural stem cells; Neurite length; Neurotoxicity; Nrf2 pathway; Rotenone

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; BETA III TUBULIN; BETA TUBULIN; COMPLEMENTARY DNA; GLIAL FIBRILLARY ACIDIC PROTEIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; KI 67 ANTIGEN; MICROTUBULE ASSOCIATED PROTEIN 2; NAD(P)H QUINONE OXIDOREDUCTASE 1; NESTIN; NEUROMODULIN; PEPTIDES AND PROTEINS; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); ROTENONE; SULFIREDOXIN 1; SYNAPTOPHYSIN; TAU PROTEIN; TRANSCRIPTION FACTOR NRF2; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; NFE2L2 PROTEIN, HUMAN; UNCOUPLING PROTEIN;

EID: 85021182553     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2017.06.006     Document Type: Article
Times cited : (43)

References (81)
  • 2
    • 84904067007 scopus 로고    scopus 로고
    • Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development
    • Al-Gubory, K.H., Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development. Reprod. Biomed. Online 29 (2014), 17–31.
    • (2014) Reprod. Biomed. Online , vol.29 , pp. 17-31
    • Al-Gubory, K.H.1
  • 3
    • 77956185722 scopus 로고    scopus 로고
    • The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes
    • Al-Gubory, K.H., Fowler, P.A., Garrel, C., The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes. Int. J. Biochem. Cell Biol. 42 (2010), 1634–1650.
    • (2010) Int. J. Biochem. Cell Biol. , vol.42 , pp. 1634-1650
    • Al-Gubory, K.H.1    Fowler, P.A.2    Garrel, C.3
  • 5
    • 84959536508 scopus 로고    scopus 로고
    • Pluripotent stem cells in disease modelling and drug discovery
    • Avior, Y., Sagi, I., Benvenisty, N., Pluripotent stem cells in disease modelling and drug discovery. Nat. Rev. Mol. Cell Biol. 17 (2016), 170–182.
    • (2016) Nat. Rev. Mol. Cell Biol. , vol.17 , pp. 170-182
    • Avior, Y.1    Sagi, I.2    Benvenisty, N.3
  • 6
    • 73949115799 scopus 로고    scopus 로고
    • Relevance of in vitro neurotoxicity testing for regulatory requirements: challenges to be considered
    • Bal-Price, A.K., Hogberg, H.T., Buzanska, L., Coecke, S., Relevance of in vitro neurotoxicity testing for regulatory requirements: challenges to be considered. Neurotoxicol. Teratol. 32 (2010), 36–41.
    • (2010) Neurotoxicol. Teratol. , vol.32 , pp. 36-41
    • Bal-Price, A.K.1    Hogberg, H.T.2    Buzanska, L.3    Coecke, S.4
  • 10
    • 85022194570 scopus 로고    scopus 로고
    • AOP3: inhibition of the mitochondrial complex I of nigra-striatal neurons leads to parkinsonian motor deficits
    • Bal-Price, A., Leist, M., Schildknecht, S., Tschudi-Monnet, F., Paini, A., Terron, A., AOP3: inhibition of the mitochondrial complex I of nigra-striatal neurons leads to parkinsonian motor deficits. https://aopwiki.org/aops/3, 2017.
    • (2017)
    • Bal-Price, A.1    Leist, M.2    Schildknecht, S.3    Tschudi-Monnet, F.4    Paini, A.5    Terron, A.6
  • 13
    • 84960539010 scopus 로고    scopus 로고
    • Bioenergetics and redox adaptations of astrocytes to neuronal activity
    • Bolaños, J.P., Bioenergetics and redox adaptations of astrocytes to neuronal activity. J. Neurochem. 139 (2016), 115–125.
    • (2016) J. Neurochem. , vol.139 , pp. 115-125
    • Bolaños, J.P.1
  • 14
    • 66249144714 scopus 로고    scopus 로고
    • Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells
    • Borland, M.K., Trimmer, P.A., Rubinstein, J.D., Keeney, P.M., Mohanakumar, K., Liu, L., Bennett, J.P. Jr., Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells. Mol. Neurodegener., 3, 2008, 21.
    • (2008) Mol. Neurodegener. , vol.3 , pp. 21
    • Borland, M.K.1    Trimmer, P.A.2    Rubinstein, J.D.3    Keeney, P.M.4    Mohanakumar, K.5    Liu, L.6    Bennett, J.P.7
  • 15
  • 16
    • 84874111758 scopus 로고    scopus 로고
    • The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation
    • Bryan, H.K., Olayanju, A., Goldring, C.E., Park, B.K., The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation. Biochem. Pharmacol. 85 (2013), 705–717.
    • (2013) Biochem. Pharmacol. , vol.85 , pp. 705-717
    • Bryan, H.K.1    Olayanju, A.2    Goldring, C.E.3    Park, B.K.4
  • 17
    • 84868691367 scopus 로고    scopus 로고
    • Mitochondrial functions in astrocytes: neuroprotective implications from oxidative damage by rotenone
    • Cabezas, R., El-Bacha, R.S., Gonzalez, J., Barreto, G.E., Mitochondrial functions in astrocytes: neuroprotective implications from oxidative damage by rotenone. Neurosci. Res. 74 (2012), 80–90.
    • (2012) Neurosci. Res. , vol.74 , pp. 80-90
    • Cabezas, R.1    El-Bacha, R.S.2    Gonzalez, J.3    Barreto, G.E.4
  • 19
    • 0035879332 scopus 로고    scopus 로고
    • Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogenous dopamine
    • Calabresi, P., Gubellini, P., Picconi, B., Centonze, D., Pisani, A., Bonsi, P., Greengard, P., Hipskind, R.A., Borrelli, E., Bernardi, G., Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogenous dopamine. J. Neurosci. 21 (2001), 5110–5120.
    • (2001) J. Neurosci. , vol.21 , pp. 5110-5120
    • Calabresi, P.1    Gubellini, P.2    Picconi, B.3    Centonze, D.4    Pisani, A.5    Bonsi, P.6    Greengard, P.7    Hipskind, R.A.8    Borrelli, E.9    Bernardi, G.10
  • 20
    • 77954064073 scopus 로고    scopus 로고
    • Astrocyte-specific overexpression of Nrf2 protects striatal neurons from mitochondrial complex II inhibition
    • Calkins, M.J., Vargas, M.R., Johnson, D.A., Johnson, J.A., Astrocyte-specific overexpression of Nrf2 protects striatal neurons from mitochondrial complex II inhibition. Toxicol. Sci. 115 (2010), 557–568.
    • (2010) Toxicol. Sci. , vol.115 , pp. 557-568
    • Calkins, M.J.1    Vargas, M.R.2    Johnson, D.A.3    Johnson, J.A.4
  • 24
  • 25
    • 85016151356 scopus 로고    scopus 로고
    • Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated protein quality control in cardiomyocytes
    • Cui, T., Lai, Y., Janicki, J.S., Wang, X., Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated protein quality control in cardiomyocytes. Front. Biosci. Landmark Ed. 21 (2016), 192–202.
    • (2016) Front. Biosci. Landmark Ed. , vol.21 , pp. 192-202
    • Cui, T.1    Lai, Y.2    Janicki, J.S.3    Wang, X.4
  • 26
    • 84947808361 scopus 로고    scopus 로고
    • Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells
    • de Oliveira, M.R., Ferreira, G.C., Schuck, P.F., Dal Bosco, S.M., Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells. Chemico-Biological Interact. 242 (2015), 396–406.
    • (2015) Chemico-Biological Interact. , vol.242 , pp. 396-406
    • de Oliveira, M.R.1    Ferreira, G.C.2    Schuck, P.F.3    Dal Bosco, S.M.4
  • 27
    • 0031005815 scopus 로고    scopus 로고
    • Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra
    • Ferrante, R.J., Schulz, J.B., Kowall, N.W., Beal, M.F., Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra. Brain Res. 753 (1997), 157–162.
    • (1997) Brain Res. , vol.753 , pp. 157-162
    • Ferrante, R.J.1    Schulz, J.B.2    Kowall, N.W.3    Beal, M.F.4
  • 30
    • 54049133773 scopus 로고    scopus 로고
    • Rotenone inhibits delayed rectifier K+ current via a protein kinase A-dependent mechanism
    • Gao, X.F., Wang, W., He, C., Rotenone inhibits delayed rectifier K+ current via a protein kinase A-dependent mechanism. Neuroreport 19 (2008), 1401–1405.
    • (2008) Neuroreport , vol.19 , pp. 1401-1405
    • Gao, X.F.1    Wang, W.2    He, C.3
  • 31
    • 84889575198 scopus 로고    scopus 로고
    • Modulation of oxidative stress as an anticancer strategy
    • Gorrini, C., Harris, I.S., Mak, T.W., Modulation of oxidative stress as an anticancer strategy. Nat. Rev. Drug Discov. 12 (2013), 931–947.
    • (2013) Nat. Rev. Drug Discov. , vol.12 , pp. 931-947
    • Gorrini, C.1    Harris, I.S.2    Mak, T.W.3
  • 32
    • 33845424655 scopus 로고    scopus 로고
    • Developmental neurotoxicity of industrial chemicals
    • Grandjean, P., Landrigan, P.J., Developmental neurotoxicity of industrial chemicals. Lancet 368 (2006), 2167–2178.
    • (2006) Lancet , vol.368 , pp. 2167-2178
    • Grandjean, P.1    Landrigan, P.J.2
  • 33
    • 84894029844 scopus 로고    scopus 로고
    • Neurobehavioural effects of developmental toxicity
    • Grandjean, P., Landrigan, P.J., Neurobehavioural effects of developmental toxicity. Lancet Neurol. 13 (2014), 330–338.
    • (2014) Lancet Neurol. , vol.13 , pp. 330-338
    • Grandjean, P.1    Landrigan, P.J.2
  • 34
    • 0029992108 scopus 로고    scopus 로고
    • Bioenergetics and glutamate excitotoxicity
    • Greene, J.G., Greenamyre, J.T., Bioenergetics and glutamate excitotoxicity. Prog. Neurobiol. 48 (1996), 613–634.
    • (1996) Prog. Neurobiol. , vol.48 , pp. 613-634
    • Greene, J.G.1    Greenamyre, J.T.2
  • 35
    • 84980052866 scopus 로고    scopus 로고
    • Ganoderma Lucidum polysaccharides protect against MPP(+) and rotenone-induced apoptosis in primary dopaminergic cell cultures through inhibiting oxidative stress
    • Guo, S.S., Cui, X.L., Rausch, W.D., Ganoderma Lucidum polysaccharides protect against MPP(+) and rotenone-induced apoptosis in primary dopaminergic cell cultures through inhibiting oxidative stress. Am. J. Neurodegener. Dis. 5 (2016), 131–144.
    • (2016) Am. J. Neurodegener. Dis. , vol.5 , pp. 131-144
    • Guo, S.S.1    Cui, X.L.2    Rausch, W.D.3
  • 36
    • 84875060374 scopus 로고    scopus 로고
    • Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration
    • Gupta, K., Chandran, S., Hardingham, G.E., Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration. Br. J. Clin. Pharmacol. 75 (2013), 907–918.
    • (2013) Br. J. Clin. Pharmacol. , vol.75 , pp. 907-918
    • Gupta, K.1    Chandran, S.2    Hardingham, G.E.3
  • 39
    • 84983598110 scopus 로고    scopus 로고
    • Downregulation of miR-384-5p attenuates rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through inhibiting endoplasmic reticulum stress
    • Jiang, M., Yun, Q., Shi, F., Niu, G., Gao, Y., Xie, S., Yu, S., Downregulation of miR-384-5p attenuates rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through inhibiting endoplasmic reticulum stress. Am. J. Physiol. Cell Physiol. 310 (2016), C755–C763.
    • (2016) Am. J. Physiol. Cell Physiol. , vol.310 , pp. C755-C763
    • Jiang, M.1    Yun, Q.2    Shi, F.3    Niu, G.4    Gao, Y.5    Xie, S.6    Yu, S.7
  • 40
    • 84969884761 scopus 로고    scopus 로고
    • Nrf2–a therapeutic target for the treatment of neurodegenerative diseases
    • Johnson, D.A., Johnson, J.A., Nrf2–a therapeutic target for the treatment of neurodegenerative diseases. Free Radic. Biol. Med. 88 (2015), 253–267.
    • (2015) Free Radic. Biol. Med. , vol.88 , pp. 253-267
    • Johnson, D.A.1    Johnson, J.A.2
  • 44
    • 0842304134 scopus 로고    scopus 로고
    • Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult
    • Kraft, A.D., Johnson, D.A., Johnson, J.A., Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. J. Neurosci. 24 (2004), 1101–1112.
    • (2004) J. Neurosci. , vol.24 , pp. 1101-1112
    • Kraft, A.D.1    Johnson, D.A.2    Johnson, J.A.3
  • 45
    • 84890566643 scopus 로고    scopus 로고
    • Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants
    • Krug, A.K., Balmer, N.V., Matt, F., Schonenberger, F., Merhof, D., Leist, M., Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants. Arch. Toxicol. 87 (2013), 2215–2231.
    • (2013) Arch. Toxicol. , vol.87 , pp. 2215-2231
    • Krug, A.K.1    Balmer, N.V.2    Matt, F.3    Schonenberger, F.4    Merhof, D.5    Leist, M.6
  • 46
    • 10644270649 scopus 로고    scopus 로고
    • Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells
    • Kweon, G.R., Marks, J.D., Krencik, R., Leung, E.H., Schumacker, P.T., Hyland, K., Kang, U.J., Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells. J. Biol. Chem. 279 (2004), 51783–51792.
    • (2004) J. Biol. Chem. , vol.279 , pp. 51783-51792
    • Kweon, G.R.1    Marks, J.D.2    Krencik, R.3    Leung, E.H.4    Schumacker, P.T.5    Hyland, K.6    Kang, U.J.7
  • 47
    • 13244277666 scopus 로고    scopus 로고
    • Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells
    • Li, J., Spletter, M.L., Johnson, D.A., Wright, L.S., Svendsen, C.N., Johnson, J.A., Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells. J. Neurochem. 92 (2005), 462–476.
    • (2005) J. Neurochem. , vol.92 , pp. 462-476
    • Li, J.1    Spletter, M.L.2    Johnson, D.A.3    Wright, L.S.4    Svendsen, C.N.5    Johnson, J.A.6
  • 48
    • 84891712243 scopus 로고    scopus 로고
    • Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling
    • Li, L., Dong, H., Song, E., Xu, X., Liu, L., Song, Y., Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling. Chemico-Biological Interact. 209 (2014), 56–67.
    • (2014) Chemico-Biological Interact. , vol.209 , pp. 56-67
    • Li, L.1    Dong, H.2    Song, E.3    Xu, X.4    Liu, L.5    Song, Y.6
  • 49
    • 84964884159 scopus 로고    scopus 로고
    • l-carnitine protects human hepatocytes from oxidative stress-induced toxicity through Akt-mediated activation of Nrf2 signaling pathway
    • Li, J., Zhang, Y., Luan, H., Chen, X., Han, Y., Wang, C., l-carnitine protects human hepatocytes from oxidative stress-induced toxicity through Akt-mediated activation of Nrf2 signaling pathway. Can. J. Physiol. Pharmacol. 94 (2016), 517–525.
    • (2016) Can. J. Physiol. Pharmacol. , vol.94 , pp. 517-525
    • Li, J.1    Zhang, Y.2    Luan, H.3    Chen, X.4    Han, Y.5    Wang, C.6
  • 50
    • 84958817773 scopus 로고    scopus 로고
    • Crosstalk between Ca2+ signaling and mitochondrial H2O2 is required for rotenone inhibition of mTOR signaling pathway leading to neuronal apoptosis
    • Liu, C., Ye, Y., Zhou, Q., Zhang, R., Zhang, H., Liu, W., Xu, C., Liu, L., Huang, S., Chen, L., Crosstalk between Ca2+ signaling and mitochondrial H2O2 is required for rotenone inhibition of mTOR signaling pathway leading to neuronal apoptosis. Oncotarget 7 (2016), 7534–7549.
    • (2016) Oncotarget , vol.7 , pp. 7534-7549
    • Liu, C.1    Ye, Y.2    Zhou, Q.3    Zhang, R.4    Zhang, H.5    Liu, W.6    Xu, C.7    Liu, L.8    Huang, S.9    Chen, L.10
  • 51
    • 84989195518 scopus 로고    scopus 로고
    • Synergistic protective effect of paeoniflorin and beta-ecdysterone against rotenone-induced neurotoxicity in PC12 cells
    • Liu, H., Yu, C., Xu, T., Zhang, X., Dong, M., Synergistic protective effect of paeoniflorin and beta-ecdysterone against rotenone-induced neurotoxicity in PC12 cells. Apoptosis 21 (2016), 1354–1365.
    • (2016) Apoptosis , vol.21 , pp. 1354-1365
    • Liu, H.1    Yu, C.2    Xu, T.3    Zhang, X.4    Dong, M.5
  • 52
    • 0034254932 scopus 로고    scopus 로고
    • Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in superoxide production
    • Luetjens, C.M., Bui, N.T., Sengpiel, B., Munstermann, G., Poppe, M., Krohn, A.J., Bauerbach, E., Krieglstein, J., Prehn, J.H., Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in superoxide production. J. Neurosci. 20 (2000), 5715–5723.
    • (2000) J. Neurosci. , vol.20 , pp. 5715-5723
    • Luetjens, C.M.1    Bui, N.T.2    Sengpiel, B.3    Munstermann, G.4    Poppe, M.5    Krohn, A.J.6    Bauerbach, E.7    Krieglstein, J.8    Prehn, J.H.9
  • 53
    • 0029052829 scopus 로고
    • A selective toxicity toward cultured mesencephalic dopaminergic neurons is induced by the synergistic effects of energetic metabolism impairment and NMDA receptor activation
    • Marey-Semper, I., Gelman, M., Levi-Strauss, M., A selective toxicity toward cultured mesencephalic dopaminergic neurons is induced by the synergistic effects of energetic metabolism impairment and NMDA receptor activation. J. Neurosci. 15 (1995), 5912–5918.
    • (1995) J. Neurosci. , vol.15 , pp. 5912-5918
    • Marey-Semper, I.1    Gelman, M.2    Levi-Strauss, M.3
  • 54
    • 85026448085 scopus 로고    scopus 로고
    • Tetramethylpyrazine ameliorates rotenone-induced Parkinson's disease in rats: involvement of its anti-inflammatory and anti-apoptotic actions
    • Michel, H.E., Tadros, M.G., Esmat, A., Khalifa, A.E., Abdel-Tawab, A.M., Tetramethylpyrazine ameliorates rotenone-induced Parkinson's disease in rats: involvement of its anti-inflammatory and anti-apoptotic actions. Mol. Neurobiol., 2016, 1–13.
    • (2016) Mol. Neurobiol. , pp. 1-13
    • Michel, H.E.1    Tadros, M.G.2    Esmat, A.3    Khalifa, A.E.4    Abdel-Tawab, A.M.5
  • 55
    • 84978537497 scopus 로고    scopus 로고
    • Neuroprotective effect of asiatic acid on rotenone-induced mitochondrial dysfunction and oxidative stress-mediated apoptosis in differentiated SH-SYS5Y cells
    • Nataraj, J., Manivasagam, T., Justin Thenmozhi, A., Essa, M.M., Neuroprotective effect of asiatic acid on rotenone-induced mitochondrial dysfunction and oxidative stress-mediated apoptosis in differentiated SH-SYS5Y cells. Nutr. Neurosci. 20 (2017), 351–359.
    • (2017) Nutr. Neurosci. , vol.20 , pp. 351-359
    • Nataraj, J.1    Manivasagam, T.2    Justin Thenmozhi, A.3    Essa, M.M.4
  • 56
    • 84930972922 scopus 로고    scopus 로고
    • Drugs of abuse in pregnancy, poor neonatal development, and future neurodegeneration. Is oxidative stress the culprit?
    • Neri, M., Bello, S., Turillazzi, E., Riezzo, I., Drugs of abuse in pregnancy, poor neonatal development, and future neurodegeneration. Is oxidative stress the culprit?. Curr. Pharm. Des. 21 (2015), 1358–1368.
    • (2015) Curr. Pharm. Des. , vol.21 , pp. 1358-1368
    • Neri, M.1    Bello, S.2    Turillazzi, E.3    Riezzo, I.4
  • 57
    • 36248981494 scopus 로고    scopus 로고
    • Toxicity Testing in the 21st Century: a Vision and a Strategy
    • National Academy Press Washington, DC
    • (NRC), N.R.C, Toxicity Testing in the 21st Century: a Vision and a Strategy. 2007, National Academy Press, Washington, DC.
    • (2007)
  • 59
    • 84939857473 scopus 로고    scopus 로고
    • Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes
    • Pei, Y., Peng, J., Behl, M., Sipes, N.S., Shockley, K.R., Rao, M.S., Tice, R.R., Zeng, X., Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes. Brain Res. 1638 (2016), 57–73.
    • (2016) Brain Res. , vol.1638 , pp. 57-73
    • Pei, Y.1    Peng, J.2    Behl, M.3    Sipes, N.S.4    Shockley, K.R.5    Rao, M.S.6    Tice, R.R.7    Zeng, X.8
  • 61
    • 84859837157 scopus 로고    scopus 로고
    • Neurite outgrowth assessment using high content analysis methodology
    • Radio, N.M., Neurite outgrowth assessment using high content analysis methodology. Methods Mol. Biol. 846 (2012), 247–260.
    • (2012) Methods Mol. Biol. , vol.846 , pp. 247-260
    • Radio, N.M.1
  • 63
    • 84856007232 scopus 로고    scopus 로고
    • The promise of induced pluripotent stem cells in research and therapy
    • Robinton, D.A., Daley, G.Q., The promise of induced pluripotent stem cells in research and therapy. Nature 481 (2012), 295–305.
    • (2012) Nature , vol.481 , pp. 295-305
    • Robinton, D.A.1    Daley, G.Q.2
  • 64
    • 84959358615 scopus 로고    scopus 로고
    • Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity
    • Ryan, K.R., Sirenko, O., Parham, F., Hsieh, J.H., Cromwell, E.F., Tice, R.R., Behl, M., Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity. Neurotoxicology 53 (2016), 271–281.
    • (2016) Neurotoxicology , vol.53 , pp. 271-281
    • Ryan, K.R.1    Sirenko, O.2    Parham, F.3    Hsieh, J.H.4    Cromwell, E.F.5    Tice, R.R.6    Behl, M.7
  • 65
    • 0037229425 scopus 로고    scopus 로고
    • Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation
    • Sherer, T.B., Kim, J.H., Betarbet, R., Greenamyre, J.T., Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation. Exp. Neurol. 179 (2003), 9–16.
    • (2003) Exp. Neurol. , vol.179 , pp. 9-16
    • Sherer, T.B.1    Kim, J.H.2    Betarbet, R.3    Greenamyre, J.T.4
  • 67
    • 84884583125 scopus 로고    scopus 로고
    • Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells
    • Steele, M.L., Fuller, S., Patel, M., Kersaitis, C., Ooi, L., Munch, G., Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells. Redox Biol. 1 (2013), 441–445.
    • (2013) Redox Biol. , vol.1 , pp. 441-445
    • Steele, M.L.1    Fuller, S.2    Patel, M.3    Kersaitis, C.4    Ooi, L.5    Munch, G.6
  • 68
    • 34548772935 scopus 로고    scopus 로고
    • Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2
    • Sun, Z., Zhang, S., Chan, J.Y., Zhang, D.D., Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. Mol. Cell Biol. 27 (2007), 6334–6349.
    • (2007) Mol. Cell Biol. , vol.27 , pp. 6334-6349
    • Sun, Z.1    Zhang, S.2    Chan, J.Y.3    Zhang, D.D.4
  • 69
    • 84866729431 scopus 로고    scopus 로고
    • Astrocyte activation: a key step in rotenone induced cytotoxicity and DNA damage
    • Swarnkar, S., Singh, S., Goswami, P., Mathur, R., Patro, I.K., Nath, C., Astrocyte activation: a key step in rotenone induced cytotoxicity and DNA damage. Neurochem. Res. 37 (2012), 2178–2189.
    • (2012) Neurochem. Res. , vol.37 , pp. 2178-2189
    • Swarnkar, S.1    Singh, S.2    Goswami, P.3    Mathur, R.4    Patro, I.K.5    Nath, C.6
  • 71
    • 70149124059 scopus 로고    scopus 로고
    • Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment
    • Tantucci, M., Mariucci, G., Taha, E., Spaccatini, C., Tozzi, A., Luchetti, E., Calabresi, P., Ambrosini, M.V., Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment. Neuroscience 163 (2009), 735–740.
    • (2009) Neuroscience , vol.163 , pp. 735-740
    • Tantucci, M.1    Mariucci, G.2    Taha, E.3    Spaccatini, C.4    Tozzi, A.5    Luchetti, E.6    Calabresi, P.7    Ambrosini, M.V.8
  • 72
    • 15544365143 scopus 로고    scopus 로고
    • Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Brain research
    • Testa, C.M., Sherer, T.B., Greenamyre, J.T., Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Brain research. Mol. Brain Res. 134 (2005), 109–118.
    • (2005) Mol. Brain Res. , vol.134 , pp. 109-118
    • Testa, C.M.1    Sherer, T.B.2    Greenamyre, J.T.3
  • 73
    • 79955057180 scopus 로고    scopus 로고
    • The nrf2/ARE pathway: a promising target to counteract mitochondrial dysfunction in Parkinson's disease
    • Tufekci, K.U., Civi Bayin, E., Genc, S., Genc, K., The nrf2/ARE pathway: a promising target to counteract mitochondrial dysfunction in Parkinson's disease. Parkinson's Dis., 2011, 2011, 314082.
    • (2011) Parkinson's Dis. , vol.2011 , pp. 314082
    • Tufekci, K.U.1    Civi Bayin, E.2    Genc, S.3    Genc, K.4
  • 74
    • 84991786853 scopus 로고    scopus 로고
    • Inhibition of aryl hydrocarbon receptor signaling and induction of NRF2-mediated antioxidant activity by cinnamaldehyde in human keratinocytes
    • Uchi, H., Yasumatsu, M., Morino-Koga, S., Mitoma, C., Furue, M., Inhibition of aryl hydrocarbon receptor signaling and induction of NRF2-mediated antioxidant activity by cinnamaldehyde in human keratinocytes. J. Dermatol Sci. 85 (2017), 36–43.
    • (2017) J. Dermatol Sci. , vol.85 , pp. 36-43
    • Uchi, H.1    Yasumatsu, M.2    Morino-Koga, S.3    Mitoma, C.4    Furue, M.5
  • 75
    • 84945326570 scopus 로고    scopus 로고
    • Akt enhances nerve growth factor-induced axon growth via activating the Nrf2/ARE pathway
    • Xia, B., Liu, H., Xie, J., Wu, R., Li, Y., Akt enhances nerve growth factor-induced axon growth via activating the Nrf2/ARE pathway. Int. J. Mol. Med. 36 (2015), 1426–1432.
    • (2015) Int. J. Mol. Med. , vol.36 , pp. 1426-1432
    • Xia, B.1    Liu, H.2    Xie, J.3    Wu, R.4    Li, Y.5
  • 76
    • 84863666597 scopus 로고    scopus 로고
    • Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson's disease models
    • Xiong, N., Long, X., Xiong, J., Jia, M., Chen, C., Huang, J., Ghoorah, D., Kong, X., Lin, Z., Wang, T., Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson's disease models. Crit. Rev. Toxicol. 42 (2012), 613–632.
    • (2012) Crit. Rev. Toxicol. , vol.42 , pp. 613-632
    • Xiong, N.1    Long, X.2    Xiong, J.3    Jia, M.4    Chen, C.5    Huang, J.6    Ghoorah, D.7    Kong, X.8    Lin, Z.9    Wang, T.10
  • 77
    • 84953253517 scopus 로고    scopus 로고
    • Releasing Nrf2 to promote neurite outgrowth
    • Yang, C., Cheng, Y., Zhao, J., Rong, J., Releasing Nrf2 to promote neurite outgrowth. Neural Regen. Res. 10 (2015), 1934–1935.
    • (2015) Neural Regen. Res. , vol.10 , pp. 1934-1935
    • Yang, C.1    Cheng, Y.2    Zhao, J.3    Rong, J.4
  • 78
    • 84923028459 scopus 로고    scopus 로고
    • An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders
    • Yang, Y., Jiang, S., Yan, J., Li, Y., Xin, Z., Lin, Y., Qu, Y., An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders. Cytokine Growth Factor Rev. 26 (2015), 47–57.
    • (2015) Cytokine Growth Factor Rev. , vol.26 , pp. 47-57
    • Yang, Y.1    Jiang, S.2    Yan, J.3    Li, Y.4    Xin, Z.5    Lin, Y.6    Qu, Y.7
  • 79
    • 84994527381 scopus 로고    scopus 로고
    • Evaluation of the rotenone-induced activation of the Nrf2 pathway in a neuronal model derived from human induced pluripotent stem cells
    • Zagoura, D., Canovas-Jorda, D., Pistollato, F., Bremer-Hoffmann, S., Bal-Price, A., Evaluation of the rotenone-induced activation of the Nrf2 pathway in a neuronal model derived from human induced pluripotent stem cells. Neurochem. Int. 106 (2017), 62–73.
    • (2017) Neurochem. Int. , vol.106 , pp. 62-73
    • Zagoura, D.1    Canovas-Jorda, D.2    Pistollato, F.3    Bremer-Hoffmann, S.4    Bal-Price, A.5
  • 81
    • 84925541204 scopus 로고    scopus 로고
    • Sulfiredoxin-1 attenuates oxidative stress via Nrf2/ARE pathway and 2-Cys Prdxs after oxygen-glucose deprivation in astrocytes
    • Zhou, Y., Duan, S., Zhou, Y., Yu, S., Wu, J., Wu, X., Zhao, J., Zhao, Y., Sulfiredoxin-1 attenuates oxidative stress via Nrf2/ARE pathway and 2-Cys Prdxs after oxygen-glucose deprivation in astrocytes. J. Mol. Neurosci. 55 (2015), 941–950.
    • (2015) J. Mol. Neurosci. , vol.55 , pp. 941-950
    • Zhou, Y.1    Duan, S.2    Zhou, Y.3    Yu, S.4    Wu, J.5    Wu, X.6    Zhao, J.7    Zhao, Y.8


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