Akt enhances nerve growth factor-induced axon growth via activating the Nrf2/ARE pathway

International Journal of Molecular Medicine

Volumn 36, Issue 5, 2015, Pages 1426-1432

  Xia, Bin ^a   Liu, Heyu ^a   Xie, Juanke ^b   Wu, Rui ^a   Li, Yali ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Akt; Axon growth; Nerve growth factor; PC12 cells; Spinal cord injury

Indexed keywords

NERVE GROWTH FACTOR; PROTEIN KINASE B; TRANSCRIPTION FACTOR NRF2; ARYLESTERASE; CARBOXYLESTERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT RESPONSIVE ELEMENT; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GENE OVEREXPRESSION; INVESTIGATIVE PROCEDURES; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; PC12 CELL LINE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; AXON; METABOLISM; NERVE CELL; OXIDATIVE STRESS; PHYSIOLOGY; RAT; SPINAL CORD INJURY; TUMOR CELL LINE;

ANIMALS; ANTIOXIDANT RESPONSE ELEMENTS; APOPTOSIS; AXONS; CARBOXYLIC ESTER HYDROLASES; CELL LINE, TUMOR; NEURONS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; SPINAL CORD INJURIES;

EID: 84945326570     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2015.2329     Document Type: Article

References (37)

1. Schwartz M, Cohen I, Lazarov Spiegler O, Moalem G, and Yoles E. The remedy may lie in ourselves: Prospects for immune cell therapy in central nervous system protection and repair. J Mol Med Berl. 77: 713 717, 1999.
2. Schnell L, and Schwab ME. Axonal regeneration in the rat spinal cord produced by an antibody against myelin associated neurite growth inhibitors. Nature. 343: 269 272, 1990.
3. Huang DW, McKerracher L, Braun PE, and David S. A thera-peutic vaccine approach to stimulate axon regeneration in the adult mammalian spinal cord. Neuron. 24: 639 647, 1999.
4. Cheng H, Cao Y, and Olson L. Spinal cord repair in adult para-plegic rats: Partial restoration of hind limb function. Science. 273: 510 513, 1996.
5. Howland DR, Bregman BS, Tessler A, and Goldberger ME. Transplants enhance locomotion in neonatal kittens whose spinal cords are transected: A behavioral and anatomical study. Exp Neurol. 135: 123 145, 1995.
6. Rapalino O, Lazarov Spiegler O, Agranov E, Velan GJ, Yoles E, Fraidakis M, Solomon A, Gepstein R, Katz A, Belkin M, et al. Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nat Med. 4: 814 821, 1998.
7. Liu Y, Kim D, Himes BT, Chow SY, Schallert T, Murray M, Tessler A, and Fischer I. Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function. J Neurosci. 19: 4370 4387, 1999.
8. McDonald JW, Liu XZ, Qu Y, Liu S, Mickey SK, Turetsky D, Gottlieb DI, and Choi DW. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med. 5: 1410 1412, 1999.
9. Ramón Cueto A, Cordero MI, Santos Benito FF, and Avila J. Functional recovery of paraplegic rats and motor axon regen-eration in their spinal cords by olfactory ensheathing glia. Neuron. 25: 425 435, 2000.
10. Davies SJ, Goucher DR, Doller C, and Silver J. Robust regen-eration of adult sensory axons in degenerating white matter of the adult rat spinal cord. J Neurosci. 19: 5810 5822, 1999.
11. Moon LD, Brecknell JE, Franklin RJ, Dunnett SB, and Fawcett JW. Robust regeneration of CNS axons through a track depleted of CNS glia. Exp Neurol. 161: 49 66, 2000.
12. Schnell L, Schneider R, Kolbeck R, Barde YA, and Schwab ME. Neurotrophin 3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Nature. 367: 170 173, 1994.
13. Sawai H, Clarke DB, Kittlerova P, Bray GM, and Aguayo AJ. Brain derived neurotrophic factor and neurotrophin 4/5 stimulate growth of axonal branches from regenerating retinal ganglion cells. J Neurosci. 16: 3887 3894, 1996.
14. Kobayashi NR, Fan DP, Giehl KM, Bedard AM, Wiegand SJ, and Tetzlaff W. BDNF and NT 4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP 43 and Talpha1 tubulin mRNA expression, and promote axonal regeneration. J Neurosci. 17: 9583 9595, 1997.
15. Bregman BS, Broude E, McAtee M, and Kelley MS. Transplants and neurotrophic factors prevent atrophy of mature CNS neurons after spinal cord injury. Exp Neurol. 149: 13 27, 1998.
16. Tischler AS, and Greene LA. Nerve growth factor induced process formation by cultured rat pheochromocytoma cells. Nature. 258: 341 342, 1975.
17. Greene LA, and Tischler AS. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA. 73: 2424 2428, 1976.
18. Mesner PW, Winters TR, and Green SH. Nerve growth factor withdrawal induced cell death in neuronal PC12 cells resembles that in sympathetic neurons. J Cell Biol. 119: 1669 1680, 1992.
19. Ahn JY. Neuroprotection signaling of nuclear akt in neuronal cells. Exp Neurobiol. 23: 200 206, 2014.
20. Polivka J Jr, and Janku F. Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway. Pharmacol Ther. 142: 164 175, 2014.
21. Kaspar JW, Niture SK, and Jaiswal AK. Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radic Biol Med. 47: 1304 1309, 2009.
22. Ma Q. Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol. 53: 401 426, 2013.
23. Sarvestani NN, Khodagholi F, Ansari N, and Farimani MM. Involvement of p CREB and phase II detoxifying enzyme system in neuroprotection mediated by the flavonoid calycopterin isolated from Dracocephalum kotschyi. Phytomedicine. 20: 939 946, 2013.
24. González Burgos E, Carretero ME, and Gómez Serranillos MP. Nrf2 dependent neuroprotective activity of diterpenoids isolated from Sideritis spp. J Ethnopharmacol. 147: 645 652, 2013.
25. Kole MH, and Stuart GJ. Signal processing in the axon initial segment. Neuron. 73: 235 247, 2012.
26. O'Donnell M, Chance RK, and Bashaw GJ. Axon growth and guidance: Receptor regulation and signal transduction. Annu Rev Neurosci. 32: 383 412, 2009.
27. McKerracher L. Spinal cord repair: Strategies to promote axon regeneration. Neurobiol Dis. 8: 11 18, 2001.
28. Lu P, Kadoya K, and Tuszynski MH. Axonal growth and connec-Tivity from neural stem cell grafts in models of spinal cord injury. Curr Opin Neurobiol. 27: 103 109, 2014.
29. Lu P, Woodruff G, Wang Y, Graham L, Hunt M, Wu D, Boehle E, Ahmad R, Poplawski G, Brock J, et al. Long distance axonal growth from human induced pluripotent stem cells after spinal cord injury. Neuron. 83: 789 796, 2014.
30. McKeon RJ, Schreiber RC, Rudge JS, and Silver J. Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes. J Neurosci. 11: 3398 3411, 1991.
31. Davies SJ, Fitch MT, Memberg SP, Hall AK, Raisman G, and Silver J. Regeneration of adult axons in white matter tracts of the central nervous system. Nature. 390: 680 683, 1997.
32. David S, and Aguayo AJ. Axonal elongation into peripheral nervous system bridges after central nervous system injury in adult rats. Science. 214: 931 933, 1981.
33. Keirstead HS, Hasan SJ, Muir GD, and Steeves JD. Suppression of the onset of myelination extends the permissive period for the functional repair of embryonic spinal cord. Proc Natl Acad Sci USA. 89: 11664 11668, 1992.
34. Bregman BS, Kunkel Bagden E, Schnell L, Dai HN, Gao D, and Schwab ME. Recovery from spinal cord injury mediated by anti-bodies to neurite growth inhibitors. Nature. 378: 498 501, 1995.
35. Weidner N, Ner A, Salimi N, and Tuszynski MH. Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury. Proc Natl Acad Sci USA. 98: 3513 3518, 2001.
36. Coumans JV, Lin TT, Dai HN, MacArthur L, McAtee M, Nash C, and Bregman BS. Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins. J Neurosci. 21: 9334 9344, 2001.
37. Wang J, Zheng Q, Zhao M, and Guo X. Neurocyte apoptosis and expressions of caspase 3 and Fas after spinal cord injury and their implication in rats. J Huazhong Univ Sci Technolog Med Sci. 26: 709 712, 2006.