Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells

Redox Biology

Volumn 1, Issue 1, 2013, Pages 441-445

  Steele, Megan L ^a   Fuller, Stacey ^a   Patel, Mili ^a   Kersaitis, Cindy ^a   Ooi, Lezanne ^b   Münch, Gerald ^a  

^a UNIVERSITY OF WESTERN SYDNEY   (Australia)

^b UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

Astroglia; Cysteinylglycine; Glutathione; Nrf2 activators

Indexed keywords

CYSTEINYLGLYCINE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; HOMOCYSTEINE; POLYGONUM CUSPIDATUM EXTRACT; RESVERATROL; SULFORAPHANE; TERT BUTYLHYDROQUINONE; THIOCTIC ACID; TRANSCRIPTION FACTOR NRF2; 2-TERT-BUTYLHYDROQUINONE; DIPEPTIDE; HYDROQUINONE DERIVATIVE; ISOTHIOCYANIC ACID DERIVATIVE; NFE2L2 PROTEIN, HUMAN; PLANT EXTRACT; STILBENE DERIVATIVE; SULFORAFAN;

ARTICLE; ASTROCYTE; CELL VIABILITY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME RELEASE; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PROCESSING; CELL SURVIVAL; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; METABOLISM; TUMOR CELL LINE;

POLYGONUM CUSPIDATUM; POLYGONUM MULTIFLORUM;

ASTROCYTES; CELL LINE, TUMOR; CELL SURVIVAL; DIPEPTIDES; GLUTATHIONE; HOMOCYSTEINE; HUMANS; HYDROQUINONES; ISOTHIOCYANATES; NF-E2-RELATED FACTOR 2; PLANT EXTRACTS; STILBENES; THIOCTIC ACID;

EID: 84884583125     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2013.08.006     Document Type: Article

References (35)

1. Althausen S., Paschen W. Homocysteine-induced changes in mRNA levels of genes coding for cytoplasmic- and endoplasmic reticulum-resident stress proteins in neuronal cell cultures. Molecular Brain Research 2000, 84:32-40.
2. Aschner M. Neuron-astrocyte interactions: implications for cellular energetics and antioxidant levels. Neurotoxicology 2000, 21:1101-1107.
3. Bender A.S., Reichelt W., Norenberg M.D. Characterization of cystine uptake in cultured astrocytes. Neurochemistry International 2000, 37:269-276.
4. Brannan T.S., Maker H.S., Weiss C., Cohen G. Regional distribution of glutathione peroxidase in the adult rat brain. Journal of Neurochemistry 1980, 35:1013-1014.
5. Buranrat B., Prawan A., Kukongviriyapan V. Optimization of resazurin-based assay for cytotoxicity test in cholangiocarcinoma cells. KKU Research Journal 2008, 8:73-80.
6. Chen X.L., Kunsch C. Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases. Current Pharmaceutical Design 2004, 10:879-891.
7. Chu X., Sun A., Liu R. Preparative isolation and purification of five compounds from the Chinese medicinal herb Polygonum cuspidatum Sieb. et Zucc by high-speed counter-current chromatography. Journal of Chromatography A 2005, 1097:33-39.
8. Correa F., Ljunggren E., Mallard C., Nilsson M., Weber S.G., Sandberg M. The Nrf2-inducible antioxidant defense in astrocytes can be both up- and down-regulated by activated microglia:involvement of p38 MAPK. Glia 2011, 59:785-799.
9. Dringen R., Hamprecht B. N-acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain. Neuroscience Letters 1999, 259:79-82.
10. Dringen R., Pfeiffer B., Hamprecht B. Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione. Journal of Neuroscience 1999, 19:562-569.
11. Dwyer B.E., Raina A.K., Perry G., Smith M.A. Homocysteine and Alzheimer's disease: a modifiable risk?. Free Radical Biology and Medicine 2004, 36:1471-1475.
12. Griffith O.W., Mulcahy R.T. The enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase. Advances in Enzymology and Related Areas of Molecular Biology 1999, 73:209-267. (xii).
13. Hager K., Kenklies M., McAfoose J., Engel J., Munch G. Alpha-lipoic acid as a new treatment option for Alzheimer's disease-a 48 months follow-up analysis. Journal of Neural Transmission Supplementa 2007, 189-193.
14. Ho P.I., Ortiz D., Rogers E., Shea T.B. Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage. Journal of Neuroscience Research 2002, 70:694-702.
15. Karelson E., Bogdanovic N., Garlind A., Winblad B., Zilmer K., Kullisaar T., Vihalemm T., Kairane C., Zilmer M. The cerebrocortical areas in normal brain aging and in Alzheimer's disease: noticeable differences in the lipid peroxidation level and in antioxidant defense. Neurochemical Research 2001, 26:353-361.
16. Kimura Y., Okuda H. Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice. Journal of Nutrition 2001, 131:1844-1849.
17. Kode A., Rajendrasozhan S., Caito S., Yang S.R., Megson I.L., Rahman I. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. American journal of physiology. Lung Cellular and Molecular Physiology 2008, 294:L478-488.
18. Kraft A.D., Johnson D.A., Johnson J.A. Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. Journal of Neuroscience 2004, 24:1101-1112.
19. Li Z., Sun L., Zhang H., Liao Y., Wang D., Zhao B., Zhu Z., Zhao J., Ma A., Han Y., Wang Y., Shi Y., Ye J., Hui R. Elevated plasma homocysteine was associated with hemorrhagic and ischemic stroke, but methylenetetrahydrofolate reductase gene C677T polymorphism was a risk factor for thrombotic stroke: a multicenter case-control study in China. Stroke 2003, 34:2085-2090.
20. Lipton S.A., Kim W.K., Choi Y.B., Kumar S., D'Emilia D.M., Rayudu P.V., Arnelle D.R., Stamler J.S. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:5923-5928.
21. Liu R.M., Hu H., Robison T.W., Forman H.J. Differential enhancement of gamma-glutamyl transpeptidase and gamma-glutamylcysteine synthetase by tert-butylhydroquinone in rat lung epithelial L2 cells. American Journal of Respiratory Cell and Molecular Biology 1996, 14:186-191.
22. Pietrzik K. Homocysteine as a cardiovascular marker and risk factor. Clinical Research in Cardiology 2006, 95(Suppl. 6):VI28-33.
23. Rababah T.M., Hettiarachchy N.S., Horax R. Total phenolics and antioxidant activities of fenugreek, green tea, black tea, grape seed, ginger, rosemary, gotu kola, and ginkgo extracts, vitamin E, and tert-butylhydroquinone. Journal of Agricultural and Food Chemistry 2004, 52:5183-5186.
24. Rahman I., Antonicelli F., MacNee W. Molecular mechanism of the regulation of glutathione synthesis by tumor necrosis factor and dexamethasone in human alveolar epithelial cells. Journal of Biological Chemistry 1999, 274:5088.
25. Schonhusen U., Kuhla S., Zitnan R., Wutzke K.D., Huber K., Moors S., Voigt J. Effect of a soy protein-based diet on ribonucleic acid metabolism in the small intestinal mucosa of goat kids. Journal of the American Dairy Science 2007, 90:2404-2412.
26. Seshadri S., Beiser A., Selhub J., Jacques P.F., Rosenberg I.H., D'Agostino R.B., Wilson P.W., Wolf P.A. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. New England Journal of Medicine 2002, 346:476-483.
27. Shay K.P., Michels A.J., Li W., Kong A.T., Hagen T.M. Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response. Biochimica et Biophysica Acta 2012, 1823:1101-1109.
28. Shih A.Y., Johnson D.A., Wong G., Kraft A.D., Jiang L., Erb H., Johnson J.A., Murphy T.H. Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress. Journal of Neuroscience 2003, 23:3394-3406.
29. Shinkai Y., Sumi D., Fukami I., Ishii T., Kumagai Y. Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes. FEBS Letters 2006, 580:1771-1774.
30. Steele M.L., Fuller S., Maczurek A.E., Kersaitis C., Ooi L., Munch G. Chronic inflammation alters production and release of glutathione and related thiols in human U373 astroglial cells. Cellular and Molecular Neurobiology 2013, 33:19-30.
31. Steele M.L., Ooi L., Munch G. Development of a high-performance liquid chromatography method for the simultaneous quantitation of glutathione and related thiols. Analytical Biochemistry 2012, 429:45-52.
32. Steele M.L., Robinson S.R. Reactive astrocytes give neurons less support: implications for Alzheimer's disease. Neurobiology of Aging 2012, 33(423):e421-413.
33. Surh Y.J. NF-kappa B and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities. Asia Pacific Journal of Clinical Nutrition 2008, 17(Suppl. 1):269-272.
34. Vargas M.R., Johnson J.A. The Nrf2-ARE cytoprotective pathway in astrocytes. Expert Reviews in Molecular Medicine 2009, 11:e17.
35. Vitvitsky V., Thomas M., Ghorpade A., Gendelman H.E., Banerjee R. A functional transsulfuration pathway in the brain links to glutathione homeostasis. Journal of Biological Chemistry 2006, 281:35785-35793.