메뉴 건너뛰기




Volumn 21, Issue 12, 2016, Pages 1354-1365

Synergistic protective effect of paeoniflorin and β-ecdysterone against rotenone-induced neurotoxicity in PC12 cells

Author keywords

Apoptosis; Paeoniflorin; Parkinson s disease; Synergism; Ecdysterone

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; CASPASE 3; CASPASE 9; ECDYSTERONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PAEONIFLORIN; PROTEIN BAX; PROTEIN KINASE C DELTA; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; ROTENONE; ROTTLERIN; TRANSCRIPTION FACTOR NRF2; GLUCOSIDE; NEUROPROTECTIVE AGENT; TERPENE;

EID: 84989195518     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-016-1293-7     Document Type: Article
Times cited : (26)

References (45)
  • 1
    • 84941634695 scopus 로고    scopus 로고
    • A systematic review on the applications of resting-state fMRI in Parkinson’s disease: does dopamine replacement therapy play a role?
    • PID: 26386442
    • Tahmasian M, Bettray LM, van Eimeren T, Drzezga A, Timmermann L, Eickhoff CR, Eickhoff SB, Eggers C (2015) A systematic review on the applications of resting-state fMRI in Parkinson’s disease: does dopamine replacement therapy play a role? Cortex 73:80–105
    • (2015) Cortex , vol.73 , pp. 80-105
    • Tahmasian, M.1    Bettray, L.M.2    van Eimeren, T.3    Drzezga, A.4    Timmermann, L.5    Eickhoff, C.R.6    Eickhoff, S.B.7    Eggers, C.8
  • 2
    • 84942499950 scopus 로고    scopus 로고
    • The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson’s disease
    • COI: 1:CAS:528:DC%2BC2MXht1Krt7zK, PID: 26134497
    • Xu Y, Deng Y, Qing H (2015) The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson’s disease. J Neurochem 135:4–18
    • (2015) J Neurochem , vol.135 , pp. 4-18
    • Xu, Y.1    Deng, Y.2    Qing, H.3
  • 4
    • 84885292221 scopus 로고    scopus 로고
    • Implications of enzyme deficiencies on mitochondrial energy metabolism and reactive oxygen species formation of neurons involved in rotenone-induced Parkinson’s disease: a model-based analysis
    • COI: 1:CAS:528:DC%2BC3sXhsFOgsr3F, PID: 23937586
    • Berndt N, Holzhütter HG, Bulik S (2013) Implications of enzyme deficiencies on mitochondrial energy metabolism and reactive oxygen species formation of neurons involved in rotenone-induced Parkinson’s disease: a model-based analysis. FEBS J 280:5080–5093
    • (2013) FEBS J , vol.280 , pp. 5080-5093
    • Berndt, N.1    Holzhütter, H.G.2    Bulik, S.3
  • 5
    • 85017301895 scopus 로고    scopus 로고
    • Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis
    • COI: 1:CAS:528:DC%2BC2MXisFartL8%3D, PID: 25304210
    • Zhou Q, Liu C, Liu W, Zhang H, Zhang R, Liu J, Zhang J, Xu C, Liu L, Huang S, Chen L (2015) Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis. Toxicol Sci 143:81–96
    • (2015) Toxicol Sci , vol.143 , pp. 81-96
    • Zhou, Q.1    Liu, C.2    Liu, W.3    Zhang, H.4    Zhang, R.5    Liu, J.6    Zhang, J.7    Xu, C.8    Liu, L.9    Huang, S.10    Chen, L.11
  • 6
    • 84949546540 scopus 로고    scopus 로고
    • Neuroprotective effects of Kukoamine B against hydrogen peroxide-induced apoptosis and potential mechanisms in SH-SY5Y cells
    • COI: 1:CAS:528:DC%2BC2MXhtFKisL%2FM, PID: 26164594
    • Hu XL, Niu YX, Zhang Q, Tian X, Gao LY, Guo LP, Meng WH, Zhao QC (2015) Neuroprotective effects of Kukoamine B against hydrogen peroxide-induced apoptosis and potential mechanisms in SH-SY5Y cells. Environ Toxicol Pharmacol 40:230–240
    • (2015) Environ Toxicol Pharmacol , vol.40 , pp. 230-240
    • Hu, X.L.1    Niu, Y.X.2    Zhang, Q.3    Tian, X.4    Gao, L.Y.5    Guo, L.P.6    Meng, W.H.7    Zhao, Q.C.8
  • 7
    • 84933516718 scopus 로고    scopus 로고
    • Significance of antioxidant potential of plants and its relevance to therapeutic applications
    • COI: 1:CAS:528:DC%2BC2MXhvVGlsLbI, PID: 26157352
    • Kasote DM, Katyare SS, Hegde MV, Bae H (2015) Significance of antioxidant potential of plants and its relevance to therapeutic applications. Int J Biol Sci 11:982–991
    • (2015) Int J Biol Sci , vol.11 , pp. 982-991
    • Kasote, D.M.1    Katyare, S.S.2    Hegde, M.V.3    Bae, H.4
  • 8
    • 84939556767 scopus 로고    scopus 로고
    • Plant-derived neuroprotective agents in Parkinson’s disease
    • PID: 26328004
    • Fu W, Zhuang W, Zhou S, Wang X (2015) Plant-derived neuroprotective agents in Parkinson’s disease. Am J Transl Res 7:1189–1202
    • (2015) Am J Transl Res , vol.7 , pp. 1189-1202
    • Fu, W.1    Zhuang, W.2    Zhou, S.3    Wang, X.4
  • 9
    • 84890109914 scopus 로고    scopus 로고
    • Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases
    • COI: 1:CAS:528:DC%2BC3sXhvVyqsr%2FP, PID: 24292194
    • Kumar H, Kim IS, More SV, Kim BW, Choi DK (2014) Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases. Nat Prod Rep 31:109–139
    • (2014) Nat Prod Rep , vol.31 , pp. 109-139
    • Kumar, H.1    Kim, I.S.2    More, S.V.3    Kim, B.W.4    Choi, D.K.5
  • 10
    • 84941917060 scopus 로고    scopus 로고
    • N-Propargyl caffeate amide (paca) potentiates nerve growth factor (NGF)-induced neurite outgrowth and attenuates 6-hydroxydopamine (6-OHDA)-induced toxicity by activating the Nrf2/HO-1 pathway
    • COI: 1:CAS:528:DC%2BC2MXhtFWqtrnP, PID: 26147318
    • Yang C, Zhao J, Cheng Y, Le XC, Rong J (2015) N-Propargyl caffeate amide (paca) potentiates nerve growth factor (NGF)-induced neurite outgrowth and attenuates 6-hydroxydopamine (6-OHDA)-induced toxicity by activating the Nrf2/HO-1 pathway. ACS Chem Neurosci 6:1560–1569
    • (2015) ACS Chem Neurosci , vol.6 , pp. 1560-1569
    • Yang, C.1    Zhao, J.2    Cheng, Y.3    Le, X.C.4    Rong, J.5
  • 11
    • 84945326570 scopus 로고    scopus 로고
    • Akt enhances nerve growth factor-induced axon growth via activating the Nrf2/ARE pathway
    • COI: 1:CAS:528:DC%2BC28XhtFOntLvI, PID: 26324295
    • Xia B, Liu H, Xie J, Wu R, Li Y (2015) Akt enhances nerve growth factor-induced axon growth via activating the Nrf2/ARE pathway. Int J Mol Med 36:1426–1432
    • (2015) Int J Mol Med , vol.36 , pp. 1426-1432
    • Xia, B.1    Liu, H.2    Xie, J.3    Wu, R.4    Li, Y.5
  • 12
    • 84940646175 scopus 로고    scopus 로고
    • Phytoestrogen β-ecdysterone protects PC12 cells against MPP+-induced neurotoxicity in vitro: involvement of PI3K-Nrf2-regulated pathway
    • COI: 1:CAS:528:DC%2BC2MXhs1ClsLvP, PID: 26048653
    • Zou Y, Wang R, Guo H, Dong M (2015) Phytoestrogen β-ecdysterone protects PC12 cells against MPP+-induced neurotoxicity in vitro: involvement of PI3K-Nrf2-regulated pathway. Toxicol Sci 147:28–38
    • (2015) Toxicol Sci , vol.147 , pp. 28-38
    • Zou, Y.1    Wang, R.2    Guo, H.3    Dong, M.4
  • 14
    • 84896546430 scopus 로고    scopus 로고
    • Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells
    • PID: 23958447
    • Pišlar AH, Zidar N, Kikelj D, Kos J (2014) Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells. Neuropharmacology 82:121–131
    • (2014) Neuropharmacology , vol.82 , pp. 121-131
    • Pišlar, A.H.1    Zidar, N.2    Kikelj, D.3    Kos, J.4
  • 15
    • 84949114983 scopus 로고    scopus 로고
    • Paeoniflorin inhibition of 6-hydroxydopamine-induced apoptosis in PC12 cells via suppressing reactive oxygen species-mediated PKCδ/NF-κB pathway
    • COI: 1:CAS:528:DC%2BC2cXhvF2mt7bI, PID: 25446358
    • Dong H, Li R, Yu C, Xu T, Zhang X, Dong M (2015) Paeoniflorin inhibition of 6-hydroxydopamine-induced apoptosis in PC12 cells via suppressing reactive oxygen species-mediated PKCδ/NF-κB pathway. Neuroscience 285:70–80
    • (2015) Neuroscience , vol.285 , pp. 70-80
    • Dong, H.1    Li, R.2    Yu, C.3    Xu, T.4    Zhang, X.5    Dong, M.6
  • 16
    • 84929519793 scopus 로고    scopus 로고
    • Multitarget intervention of Fasudil in the neuroprotection of dopaminergic neurons in MPTP-mouse model of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BC2MXlt1Cju7c%3D, PID: 25908255
    • Zhao YF, Zhang Q, Xi JY, Li YH, Ma CG, Xiao BG (2015) Multitarget intervention of Fasudil in the neuroprotection of dopaminergic neurons in MPTP-mouse model of Parkinson’s disease. J Neurol Sci 353:28–37
    • (2015) J Neurol Sci , vol.353 , pp. 28-37
    • Zhao, Y.F.1    Zhang, Q.2    Xi, J.Y.3    Li, Y.H.4    Ma, C.G.5    Xiao, B.G.6
  • 17
    • 84901675919 scopus 로고    scopus 로고
    • Towards structural systems pharmacology to study complex diseases and personalized medicine
    • PID: 24830652
    • Xie L, Ge X, Tan H, Xie L, Zhang Y, Hart T, Yang X, Bourne PE (2014) Towards structural systems pharmacology to study complex diseases and personalized medicine. PLoS Comput Biol 10:e1003554
    • (2014) PLoS Comput Biol , vol.10
    • Xie, L.1    Ge, X.2    Tan, H.3    Xie, L.4    Zhang, Y.5    Hart, T.6    Yang, X.7    Bourne, P.E.8
  • 18
    • 84947242324 scopus 로고    scopus 로고
    • Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BC2MXhvVOru77F, PID: 26578166
    • Liu LF, Song JX, Lu JH, Huang YY, Zeng Y, Chen LL, Durairajan SS, Han QB, Li M (2015) Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson’s disease. Sci Rep 5:16862
    • (2015) Sci Rep , vol.5 , pp. 16862
    • Liu, L.F.1    Song, J.X.2    Lu, J.H.3    Huang, Y.Y.4    Zeng, Y.5    Chen, L.L.6    Durairajan, S.S.7    Han, Q.B.8    Li, M.9
  • 19
    • 79951597391 scopus 로고    scopus 로고
    • High-throughput screening for bioactive components from traditional Chinese medicine
    • COI: 1:CAS:528:DC%2BC3cXhsFarsb7I, PID: 20883195
    • Zhu Y, Zhang Z, Zhang M, Mais DE, Wang MW (2010) High-throughput screening for bioactive components from traditional Chinese medicine. Comb Chem High Throughput Screen 13:837–848
    • (2010) Comb Chem High Throughput Screen , vol.13 , pp. 837-848
    • Zhu, Y.1    Zhang, Z.2    Zhang, M.3    Mais, D.E.4    Wang, M.W.5
  • 20
    • 33645672106 scopus 로고    scopus 로고
    • Validation of the 2−∆∆Ct calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts
    • COI: 1:CAS:528:DC%2BD28XislOlurc%3D, PID: 16531770
    • Arocho A, Chen B, Ladanyi M, Pan Q (2006) Validation of the 2−∆∆Ct calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts. Diagn Mol Pathol 15:56–61
    • (2006) Diagn Mol Pathol , vol.15 , pp. 56-61
    • Arocho, A.1    Chen, B.2    Ladanyi, M.3    Pan, Q.4
  • 21
    • 84892412571 scopus 로고    scopus 로고
    • Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis
    • COI: 1:CAS:528:DC%2BC3sXhs1OltbnE, PID: 24162660
    • Westphal D, Kluck RM, Dewson G (2014) Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis. Cell Death Differ 21:196–205
    • (2014) Cell Death Differ , vol.21 , pp. 196-205
    • Westphal, D.1    Kluck, R.M.2    Dewson, G.3
  • 22
    • 68949141833 scopus 로고    scopus 로고
    • Opening the doors to cytochrome c: changes in mitochondrial shape and apoptosis
    • COI: 1:CAS:528:DC%2BD1MXhtVentbvE, PID: 19393761
    • Scorrano L (2009) Opening the doors to cytochrome c: changes in mitochondrial shape and apoptosis. Int J Biochem Cell Biol 41:1875–1883
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 1875-1883
    • Scorrano, L.1
  • 24
    • 84942506441 scopus 로고    scopus 로고
    • Nrf2-ARE signals mediated the anti-oxidative action of electroacupuncture in an MPTP mouse model of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BC2MXhslCqtb%2FM, PID: 26118717
    • Lv E, Deng J, Yu Y, Wang Y, Gong X, Jia J, Wang X (2015) Nrf2-ARE signals mediated the anti-oxidative action of electroacupuncture in an MPTP mouse model of Parkinson’s disease. Free Radic Res 49:1296–1307
    • (2015) Free Radic Res , vol.49 , pp. 1296-1307
    • Lv, E.1    Deng, J.2    Yu, Y.3    Wang, Y.4    Gong, X.5    Jia, J.6    Wang, X.7
  • 26
    • 32444447358 scopus 로고    scopus 로고
    • NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta
    • COI: 1:CAS:528:DC%2BD28XisVansb4%3D, PID: 16483929
    • Liu J, Yang D, Minemoto Y, Leitges M, Rosner MR, Lin A (2006) NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell 21:467–480
    • (2006) Mol Cell , vol.21 , pp. 467-480
    • Liu, J.1    Yang, D.2    Minemoto, Y.3    Leitges, M.4    Rosner, M.R.5    Lin, A.6
  • 27
    • 84893151204 scopus 로고    scopus 로고
    • Therapy for Parkinson’s disease: what is in the pipeline?
    • COI: 1:CAS:528:DC%2BC2cXhsFCiurw%3D
    • Stocchi F (2014) Therapy for Parkinson’s disease: what is in the pipeline? Neurother 11:24–33
    • (2014) Neurother , vol.11 , pp. 24-33
    • Stocchi, F.1
  • 28
    • 84872139132 scopus 로고    scopus 로고
    • Strategies and techniques for multi-component drug design from medicinal herbs and traditional Chinese medicine
    • COI: 1:CAS:528:DC%2BC38XhtF2jtrjJ, PID: 22690682
    • Wang Y, Fan X, Qu H, Gao X, Cheng Y (2012) Strategies and techniques for multi-component drug design from medicinal herbs and traditional Chinese medicine. Curr Top Med Chem 12:1356–1362
    • (2012) Curr Top Med Chem , vol.12 , pp. 1356-1362
    • Wang, Y.1    Fan, X.2    Qu, H.3    Gao, X.4    Cheng, Y.5
  • 29
    • 84925061204 scopus 로고    scopus 로고
    • 2-induced apoptosis in PC12 cells by modulation of reactive oxygen species and the inflammatory response
    • COI: 1:CAS:528:DC%2BC2MXoslWmtrw%3D, PID: 26136891
    • 2-induced apoptosis in PC12 cells by modulation of reactive oxygen species and the inflammatory response. Exp Ther Med 9:1768–1772
    • (2015) Exp Ther Med , vol.9 , pp. 1768-1772
    • Li, P.1    Li, Z.2
  • 30
    • 84922902834 scopus 로고    scopus 로고
    • Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: a theoretical review
    • COI: 1:CAS:528:DC%2BC2cXhvFehur7N, PID: 25153586
    • Salminen LE, Paul RH (2014) Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: a theoretical review. Rev Neurosci 25:805–819
    • (2014) Rev Neurosci , vol.25 , pp. 805-819
    • Salminen, L.E.1    Paul, R.H.2
  • 31
    • 84878607066 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite serum levels in Parkinson’s disease: correlation of oxidative stress and the severity of the disease
    • COI: 1:STN:280:DC%2BC3sngsFGltQ%3D%3D, PID: 23640445
    • Kouti L, Noroozian M, Akhondzadeh S, Abdollahi M, Javadi MR, Faramarzi MA, Mousavi S, Ghaeli P (2013) Nitric oxide and peroxynitrite serum levels in Parkinson’s disease: correlation of oxidative stress and the severity of the disease. Eur Rev Med Pharmacol Sci 17:964–970
    • (2013) Eur Rev Med Pharmacol Sci , vol.17 , pp. 964-970
    • Kouti, L.1    Noroozian, M.2    Akhondzadeh, S.3    Abdollahi, M.4    Javadi, M.R.5    Faramarzi, M.A.6    Mousavi, S.7    Ghaeli, P.8
  • 32
    • 84940467197 scopus 로고    scopus 로고
    • Investigating the role of Sirt1-modulated oxidative stress in relation to benign paroxysmal positional vertigo and Parkinson’s disease
    • COI: 1:CAS:528:DC%2BC2MXhtVKmtr7E, PID: 26130063
    • Tsai KL, Cheng YY, Leu HB, Lee YY, Chen TJ, Liu DH, Kao CL (2015) Investigating the role of Sirt1-modulated oxidative stress in relation to benign paroxysmal positional vertigo and Parkinson’s disease. Neurobiol Aging 36:2607–2616
    • (2015) Neurobiol Aging , vol.36 , pp. 2607-2616
    • Tsai, K.L.1    Cheng, Y.Y.2    Leu, H.B.3    Lee, Y.Y.4    Chen, T.J.5    Liu, D.H.6    Kao, C.L.7
  • 33
    • 84907563036 scopus 로고    scopus 로고
    • Mitochondria-derived reactive oxygen species mediate caspase-dependent and -independent neuronal deaths
    • COI: 1:CAS:528:DC%2BC2cXhsFyitLbI, PID: 25239010
    • McManus MJ, Murphy MP, Franklin JL (2014) Mitochondria-derived reactive oxygen species mediate caspase-dependent and -independent neuronal deaths. Mol Cell Neurosci 63:13–23
    • (2014) Mol Cell Neurosci , vol.63 , pp. 13-23
    • McManus, M.J.1    Murphy, M.P.2    Franklin, J.L.3
  • 34
    • 84906751686 scopus 로고    scopus 로고
    • Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells
    • COI: 1:CAS:528:DC%2BC2cXhtleitbbP, PID: 25109238
    • Perfeito R, Lázaro DF, Outeiro TF, Rego AC (2014) Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells. Mol Cell Neurosci 62:51–59
    • (2014) Mol Cell Neurosci , vol.62 , pp. 51-59
    • Perfeito, R.1    Lázaro, D.F.2    Outeiro, T.F.3    Rego, A.C.4
  • 36
    • 84899726082 scopus 로고    scopus 로고
    • Polyhydroxylated fullerene attenuates oxidative stress-induced apoptosis via a fortifying Nrf2-regulated cellular antioxidant defence system
    • PID: 24812508
    • Ye S, Chen M, Jiang Y, Chen M, Zhou T, Wang, Y, Hou Z, Ren L (2014) Polyhydroxylated fullerene attenuates oxidative stress-induced apoptosis via a fortifying Nrf2-regulated cellular antioxidant defence system. Int J Nanomedicine 9:2073–2087
    • (2014) Int J Nanomedicine , vol.9 , pp. 2073-2087
    • Ye, S.1    Chen, M.2    Jiang, Y.3    Chen, M.4    Zhou, T.5    Wang6    Hou, Z.7    Ren, L.8
  • 37
    • 84907997019 scopus 로고    scopus 로고
    • Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity
    • COI: 1:CAS:528:DC%2BC2cXhslagu7zJ, PID: 25286336
    • Tsou YH, Shih CT, Ching CH, Huang JY, Jen CJ, Yu L, Kuo YM, Wu FS, Chuang JI (2015) Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity. Exp Neurol 263:50–62
    • (2015) Exp Neurol , vol.263 , pp. 50-62
    • Tsou, Y.H.1    Shih, C.T.2    Ching, C.H.3    Huang, J.Y.4    Jen, C.J.5    Yu, L.6    Kuo, Y.M.7    Wu, F.S.8    Chuang, J.I.9
  • 38
    • 84928795625 scopus 로고    scopus 로고
    • Investigating Bax subcellular localization and membrane integration
    • Dewson G (2015) Investigating Bax subcellular localization and membrane integration. Cold Spring Harb Protoc 467–471
    • (2015) Cold Spring Harb Protoc , pp. 467-471
    • Dewson, G.1
  • 39
    • 84924658110 scopus 로고    scopus 로고
    • α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BC2MXivFGltLk%3D, PID: 25416158
    • Harischandra DS, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG (2015) α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson’s disease. Toxicol Sci 143:454–468
    • (2015) Toxicol Sci , vol.143 , pp. 454-468
    • Harischandra, D.S.1    Jin, H.2    Anantharam, V.3    Kanthasamy, A.4    Kanthasamy, A.G.5
  • 40
    • 84885553390 scopus 로고    scopus 로고
    • Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson’s disease mice
    • COI: 1:CAS:528:DC%2BC3sXhvVSltr7N, PID: 24095822
    • Kavitha M, Nataraj J, Essa MM, Memon MA, Manivasagam T (2013) Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson’s disease mice. Chem Biol Interact 206:239–247
    • (2013) Chem Biol Interact , vol.206 , pp. 239-247
    • Kavitha, M.1    Nataraj, J.2    Essa, M.M.3    Memon, M.A.4    Manivasagam, T.5
  • 42
    • 25644442285 scopus 로고    scopus 로고
    • Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death
    • COI: 1:CAS:528:DC%2BD2MXpslCgsr0%3D, PID: 15978696
    • Kaul S, Anantharam V, Kanthasamy A, Kanthasamy AG (2005) Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death. Brain Res Mol Brain Res 139:137–152
    • (2005) Brain Res Mol Brain Res , vol.139 , pp. 137-152
    • Kaul, S.1    Anantharam, V.2    Kanthasamy, A.3    Kanthasamy, A.G.4
  • 43
    • 1642362529 scopus 로고    scopus 로고
    • Suppression of caspase-3-dependent proteolytic activation of protein kinase C delta by small interfering RNA prevents MPP+-induced dopaminergic degeneration
    • COI: 1:CAS:528:DC%2BD2cXitFKmsbo%3D, PID: 15033169
    • Yang Y, Kaul S, Zhang D, Anantharam V, Kanthasamy AG (2004) Suppression of caspase-3-dependent proteolytic activation of protein kinase C delta by small interfering RNA prevents MPP+-induced dopaminergic degeneration. Mol Cell Neurosci 25:406–421
    • (2004) Mol Cell Neurosci , vol.25 , pp. 406-421
    • Yang, Y.1    Kaul, S.2    Zhang, D.3    Anantharam, V.4    Kanthasamy, A.G.5
  • 44
    • 4444260453 scopus 로고    scopus 로고
    • Satoh A, Gukovskaya AS, Nieto JM, Cheng J.H, Gukovsky I, Reeve JRPKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells
    • Satoh A, Gukovskaya AS, Nieto JM, Cheng J.H, Gukovsky I, Reeve JR. Jr, Shimosegawa T, Pandol SJ (2004) PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol 287:G582–G591
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287 , pp. G582-G591
    • Jr, S.T.1    Pandol, S.J.2
  • 45
    • 84942989722 scopus 로고    scopus 로고
    • Assessment of protective role of multifunctional dopamine agonist D-512 against oxidative stress produced by depletion of glutathione in PC12 cells: implication in neuroprotective therapy for Parkinson’s disease
    • COI: 1:CAS:528:DC%2BC2MXht1amtrrJ, PID: 26201265
    • Voshavar C, Shah M, Xu L, Dutta AK (2015) Assessment of protective role of multifunctional dopamine agonist D-512 against oxidative stress produced by depletion of glutathione in PC12 cells: implication in neuroprotective therapy for Parkinson’s disease. Neurotox Res 28:302–318
    • (2015) Neurotox Res , vol.28 , pp. 302-318
    • Voshavar, C.1    Shah, M.2    Xu, L.3    Dutta, A.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.