Development of a pluripotent stem cell derived neuronal model to identify chemically induced pathway perturbations in relation to neurotoxicity: Effects of CREB pathway inhibition

Toxicology and Applied Pharmacology

Volumn 280, Issue 2, 2014, Pages 378-388

  Pistollato, Francesca ^a   Louisse, Jochem ^a   Scelfo, Bibiana ^a   Mennecozzi, Milena ^a   Accordi, Benedetta ^b   Basso, Giuseppe ^b   Gaspar, John Antonydas ^c   Zagoura, Dimitra ^a   Barilari, Manuela ^a   Palosaari, Taina ^a   Sachinidis, Agapios ^c   Bremer Hoffmann, Susanne ^a  

^a JOINT RESEARCH CENTRE   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

CREB pathway; Embryonic stem cells; Induced pluripotent stem cells; KG 501; Neuronal derivatives

Indexed keywords

2 NAPHTHOL; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; NAPHTHOL AS-E PHOSPHATE; NAPHTHOL DERIVATIVE; ORGANOPHOSPHATE;

ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; FEMALE; FETUS; GLIA; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEUROTOXICITY; PLURIPOTENT STEM CELL; SIGNAL TRANSDUCTION; SYNAPTOGENESIS; ANTAGONISTS AND INHIBITORS; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION PROFILING; PHYSIOLOGY; SYNAPSE;

CELL DIFFERENTIATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; EMBRYONIC STEM CELLS; GENE EXPRESSION PROFILING; HUMANS; INDUCED PLURIPOTENT STEM CELLS; NAPHTHOLS; NEURONS; ORGANOPHOSPHATES; SIGNAL TRANSDUCTION; SYNAPSES;

EID: 84908388684     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.08.007     Document Type: Article

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