메뉴 건너뛰기




Volumn 106, Issue , 2017, Pages 62-73

Evaluation of the rotenone-induced activation of the Nrf2 pathway in a neuronal model derived from human induced pluripotent stem cells

Author keywords

Human induced pluripotent stem cells; Neuronal glial cultures; Nrf2 pathway; Rotenone

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; ROTENONE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR NRF2; TYROSINE 3 MONOOXYGENASE; VESICULAR GLUTAMATE TRANSPORTER 1; INSECTICIDE; NFE2L2 PROTEIN, HUMAN;

EID: 84994527381     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2016.09.004     Document Type: Article
Times cited : (49)

References (58)
  • 1
    • 84959536508 scopus 로고    scopus 로고
    • Pluripotent stem cells in disease modelling and drug discovery
    • Mar
    • Avior, Y., Sagi, I., Benvenisty, N., Pluripotent stem cells in disease modelling and drug discovery. Nat. Rev. Mol. Cell Biol. 17:3 (2016 Mar), 170–182.
    • (2016) Nat. Rev. Mol. Cell Biol. , vol.17 , Issue.3 , pp. 170-182
    • Avior, Y.1    Sagi, I.2    Benvenisty, N.3
  • 4
    • 73949115799 scopus 로고    scopus 로고
    • Relevance of in vitro neurotoxicity testing for regulatory requirements: challenges to be considered
    • Bal-Price, A.K., Hogberg, H.T., Buzanska, L., Coecke, S., Relevance of in vitro neurotoxicity testing for regulatory requirements: challenges to be considered. Neurotoxicol Teratol. 32 (2010), 36–41.
    • (2010) Neurotoxicol Teratol. , vol.32 , pp. 36-41
    • Bal-Price, A.K.1    Hogberg, H.T.2    Buzanska, L.3    Coecke, S.4
  • 5
    • 77952419467 scopus 로고    scopus 로고
    • New roles for astrocytes in developing synaptic circuits
    • Barker, A.J., Ullian, E.M., New roles for astrocytes in developing synaptic circuits. Commun. Integr. Biol. 1 (2008), 207–211.
    • (2008) Commun. Integr. Biol. , vol.1 , pp. 207-211
    • Barker, A.J.1    Ullian, E.M.2
  • 6
    • 0033522924 scopus 로고    scopus 로고
    • Titrating the effects of mitochondrial complex I impairment in the cell physiology
    • Barrientos, A., Moraes, C.T., Titrating the effects of mitochondrial complex I impairment in the cell physiology. J. Biol. Chem. 274 (1999), 16188–16197.
    • (1999) J. Biol. Chem. , vol.274 , pp. 16188-16197
    • Barrientos, A.1    Moraes, C.T.2
  • 8
    • 84874111758 scopus 로고    scopus 로고
    • The Nrf2 cell defence pathway: keap1-dependent and -independent mechanisms of regulation
    • Bryan, H.K., Olayanju, A., Goldring, C.E., Park, B.K., The Nrf2 cell defence pathway: keap1-dependent and -independent mechanisms of regulation. Biochem. Pharmacol. 85 (2013), 705–717.
    • (2013) Biochem. Pharmacol. , vol.85 , pp. 705-717
    • Bryan, H.K.1    Olayanju, A.2    Goldring, C.E.3    Park, B.K.4
  • 9
    • 84868691367 scopus 로고    scopus 로고
    • Mitochondrial functions in astrocytes: neuroprotective implications from oxidative damage by rotenone
    • Cabezas, R., El-Bacha, R.S., Gonzalez, J., Barreto, G.E., Mitochondrial functions in astrocytes: neuroprotective implications from oxidative damage by rotenone. Neurosci. Res. 74 (2012), 80–90.
    • (2012) Neurosci. Res. , vol.74 , pp. 80-90
    • Cabezas, R.1    El-Bacha, R.S.2    Gonzalez, J.3    Barreto, G.E.4
  • 11
    • 84872013374 scopus 로고    scopus 로고
    • Adapting human pluripotent stem cells to high-throughput and high-content screening
    • Desbordes, S.C., Studer, L., Adapting human pluripotent stem cells to high-throughput and high-content screening. Nat. Protoc. 8 (2013), 111–130.
    • (2013) Nat. Protoc. , vol.8 , pp. 111-130
    • Desbordes, S.C.1    Studer, L.2
  • 12
    • 79951471283 scopus 로고    scopus 로고
    • The role(s) of astrocytes and astrocyte activity in neurometabolism, neurovascular coupling, and the production of functional neuroimaging signals
    • Figley, C.R., Stroman, P.W., The role(s) of astrocytes and astrocyte activity in neurometabolism, neurovascular coupling, and the production of functional neuroimaging signals. Eur. J. Neurosci. 33 (2011), 577–588.
    • (2011) Eur. J. Neurosci. , vol.33 , pp. 577-588
    • Figley, C.R.1    Stroman, P.W.2
  • 14
    • 54049133773 scopus 로고    scopus 로고
    • Rotenone inhibits delayed rectifier K+ current via a protein kinase A-dependent mechanism
    • Gao, X.F., Wang, W., He, C., Rotenone inhibits delayed rectifier K+ current via a protein kinase A-dependent mechanism. Neuroreport 19 (2008), 1401–1405.
    • (2008) Neuroreport , vol.19 , pp. 1401-1405
    • Gao, X.F.1    Wang, W.2    He, C.3
  • 15
    • 84889575198 scopus 로고    scopus 로고
    • Modulation of oxidative stress as an anticancer strategy
    • Gorrini, C., Harris, I.S., Mak, T.W., Modulation of oxidative stress as an anticancer strategy. Nat. Rev. Drug Discov. 12 (2013), 931–947.
    • (2013) Nat. Rev. Drug Discov. , vol.12 , pp. 931-947
    • Gorrini, C.1    Harris, I.S.2    Mak, T.W.3
  • 16
    • 84938694329 scopus 로고    scopus 로고
    • Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention
    • Harder, B., Jiang, T., Wu, T., Tao, S., de la Vega, M.R., Tian, W., Chapman, E., Zhang, D.D., Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention. Biochem. Soc. Trans. 43 (2015), 680–686.
    • (2015) Biochem. Soc. Trans. , vol.43 , pp. 680-686
    • Harder, B.1    Jiang, T.2    Wu, T.3    Tao, S.4    de la Vega, M.R.5    Tian, W.6    Chapman, E.7    Zhang, D.D.8
  • 17
    • 84868249403 scopus 로고    scopus 로고
    • Genetic polymorphisms and protein expression of NRF2 and Sulfiredoxin predict survival outcomes in breast cancer
    • Hartikainen, J.M., Tengstrom, M., Kosma, V.M., Kinnula, V.L., Mannermaa, A., Soini, Y., Genetic polymorphisms and protein expression of NRF2 and Sulfiredoxin predict survival outcomes in breast cancer. Cancer Res. 72 (2012), 5537–5546.
    • (2012) Cancer Res. , vol.72 , pp. 5537-5546
    • Hartikainen, J.M.1    Tengstrom, M.2    Kosma, V.M.3    Kinnula, V.L.4    Mannermaa, A.5    Soini, Y.6
  • 19
    • 0345672740 scopus 로고    scopus 로고
    • Hypoxic upregulation of tyrosine hydroxylase gene expression is paralleled, but not induced, by increased generation of reactive oxygen species in PC12 cells
    • Hohler, B., Lange, B., Holzapfel, B., Goldenberg, A., Hanze, J., Sell, A., Testan, H., Moller, W., Kummer, W., Hypoxic upregulation of tyrosine hydroxylase gene expression is paralleled, but not induced, by increased generation of reactive oxygen species in PC12 cells. FEBS Lett. 457 (1999), 53–56.
    • (1999) FEBS Lett. , vol.457 , pp. 53-56
    • Hohler, B.1    Lange, B.2    Holzapfel, B.3    Goldenberg, A.4    Hanze, J.5    Sell, A.6    Testan, H.7    Moller, W.8    Kummer, W.9
  • 21
    • 0028982744 scopus 로고
    • Measurement of striatal H2O2 by microdialysis following global forebrain ischemia and reperfusion in the rat: correlation with the cytotoxic potential of H2O2 in vitro
    • Hyslop, P.A., Zhang, Z., Pearson, D.V., Phebus, L.A., Measurement of striatal H2O2 by microdialysis following global forebrain ischemia and reperfusion in the rat: correlation with the cytotoxic potential of H2O2 in vitro. Brain Res. 671 (1995), 181–186.
    • (1995) Brain Res. , vol.671 , pp. 181-186
    • Hyslop, P.A.1    Zhang, Z.2    Pearson, D.V.3    Phebus, L.A.4
  • 24
    • 84878785993 scopus 로고    scopus 로고
    • The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer
    • Kansanen, E., Kuosmanen, S.M., Leinonen, H., Levonen, A.L., The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer. Redox Biol. 1 (2013), 45–49.
    • (2013) Redox Biol. , vol.1 , pp. 45-49
    • Kansanen, E.1    Kuosmanen, S.M.2    Leinonen, H.3    Levonen, A.L.4
  • 27
    • 84861200262 scopus 로고    scopus 로고
    • The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk
    • Kumar, K.K., Aboud, A.A., Bowman, A.B., The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk. Neurotoxicology 33 (2012), 518–529.
    • (2012) Neurotoxicology , vol.33 , pp. 518-529
    • Kumar, K.K.1    Aboud, A.A.2    Bowman, A.B.3
  • 28
    • 0141621061 scopus 로고    scopus 로고
    • NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons
    • Lee, J.M., Shih, A.Y., Murphy, T.H., Johnson, J.A., NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. J. Biol. Chem. 278 (2003), 37948–37956.
    • (2003) J. Biol. Chem. , vol.278 , pp. 37948-37956
    • Lee, J.M.1    Shih, A.Y.2    Murphy, T.H.3    Johnson, J.A.4
  • 29
    • 84891712243 scopus 로고    scopus 로고
    • Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling
    • Li, L., Dong, H., Song, E., Xu, X., Liu, L., Song, Y., Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling. Chem. Biol. Interact. 209 (2014), 56–67.
    • (2014) Chem. Biol. Interact. , vol.209 , pp. 56-67
    • Li, L.1    Dong, H.2    Song, E.3    Xu, X.4    Liu, L.5    Song, Y.6
  • 30
    • 84867034260 scopus 로고    scopus 로고
    • Role of nrf2 in oxidative stress and toxicity
    • Ma, Q., Role of nrf2 in oxidative stress and toxicity. Annu. Rev. Pharmacol. Toxicol. 53 (2013), 401–426.
    • (2013) Annu. Rev. Pharmacol. Toxicol. , vol.53 , pp. 401-426
    • Ma, Q.1
  • 31
    • 0033971898 scopus 로고    scopus 로고
    • Mitochondria and neuronal survival
    • Nicholls, D.G., Budd, S.L., Mitochondria and neuronal survival. Physiol. Rev. 80 (2000), 315–360.
    • (2000) Physiol. Rev. , vol.80 , pp. 315-360
    • Nicholls, D.G.1    Budd, S.L.2
  • 32
    • 85052722223 scopus 로고    scopus 로고
    • Toxicity Testing in the 21st Century: a Vision and a Strategy
    • National Academy Press Washington (DC) ISBN: 978-0-309-15173-3
    • NRC, Toxicity Testing in the 21st Century: a Vision and a Strategy. 2007, National Academy Press, Washington (DC), 10.17226/11970 ISBN: 978-0-309-15173-3.
    • (2007)
    • NRC1
  • 34
    • 84893772545 scopus 로고    scopus 로고
    • Long-term electrophysiological activity and pharmacological response of a human induced pluripotent stem cell-derived neuron and astrocyte co-culture
    • Odawara, A., Saitoh, Y., Alhebshi, A.H., Gotoh, M., Suzuki, I., Long-term electrophysiological activity and pharmacological response of a human induced pluripotent stem cell-derived neuron and astrocyte co-culture. Biochem. Biophys. Res. Commun. 443 (2014), 1176–1181.
    • (2014) Biochem. Biophys. Res. Commun. , vol.443 , pp. 1176-1181
    • Odawara, A.1    Saitoh, Y.2    Alhebshi, A.H.3    Gotoh, M.4    Suzuki, I.5
  • 35
    • 80052745524 scopus 로고    scopus 로고
    • Pesticidal suicide: adult fatal rotenone poisoning
    • Patel, F., Pesticidal suicide: adult fatal rotenone poisoning. J. Forensic Leg. Med. 18 (2011), 340–342.
    • (2011) J. Forensic Leg. Med. , vol.18 , pp. 340-342
    • Patel, F.1
  • 36
    • 84939857473 scopus 로고    scopus 로고
    • Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes
    • Pei, Y., Peng, J., Behl, M., Sipes, N.S., Shockley, K.R., Rao, M.S., Tice, R.R., Zeng, X., Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes. Brain Res. 1638 (2016), 57–73.
    • (2016) Brain Res. , vol.1638 , pp. 57-73
    • Pei, Y.1    Peng, J.2    Behl, M.3    Sipes, N.S.4    Shockley, K.R.5    Rao, M.S.6    Tice, R.R.7    Zeng, X.8
  • 37
    • 84878205912 scopus 로고    scopus 로고
    • Using human pluripotent stem cell-derived dopaminergic neurons to evaluate candidate Parkinson's disease therapeutic agents in MPP+ and rotenone models
    • Peng, J., Liu, Q., Rao, M.S., Zeng, X., Using human pluripotent stem cell-derived dopaminergic neurons to evaluate candidate Parkinson's disease therapeutic agents in MPP+ and rotenone models. J. Biomol. Screen 18 (2013), 522–533.
    • (2013) J. Biomol. Screen , vol.18 , pp. 522-533
    • Peng, J.1    Liu, Q.2    Rao, M.S.3    Zeng, X.4
  • 40
    • 37249051817 scopus 로고    scopus 로고
    • Dopaminergic neurons are preferentially sensitive to long-term rotenone toxicity in primary cell culture
    • Radad, K., Gille, G., Rausch, W.D., Dopaminergic neurons are preferentially sensitive to long-term rotenone toxicity in primary cell culture. Toxicol. In Vitro 22 (2008), 68–74.
    • (2008) Toxicol. In Vitro , vol.22 , pp. 68-74
    • Radad, K.1    Gille, G.2    Rausch, W.D.3
  • 42
    • 84856007232 scopus 로고    scopus 로고
    • The promise of induced pluripotent stem cells in research and therapy
    • Robinton, D.A., Daley, G.Q., The promise of induced pluripotent stem cells in research and therapy. Nature 481 (2012), 295–305.
    • (2012) Nature , vol.481 , pp. 295-305
    • Robinton, D.A.1    Daley, G.Q.2
  • 43
    • 58149472202 scopus 로고    scopus 로고
    • Synaptic modulation by astrocytes via Ca2+-dependent glutamate release
    • Santello, M., Volterra, A., Synaptic modulation by astrocytes via Ca2+-dependent glutamate release. Neuroscience 158 (2009), 253–259.
    • (2009) Neuroscience , vol.158 , pp. 253-259
    • Santello, M.1    Volterra, A.2
  • 44
    • 60349106093 scopus 로고    scopus 로고
    • Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice
    • Satoh, T., Harada, N., Hosoya, T., Tohyama, K., Yamamoto, M., Itoh, K., Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice. Biochem. Biophys. Res. Commun. 380 (2009), 298–302.
    • (2009) Biochem. Biophys. Res. Commun. , vol.380 , pp. 298-302
    • Satoh, T.1    Harada, N.2    Hosoya, T.3    Tohyama, K.4    Yamamoto, M.5    Itoh, K.6
  • 45
    • 0037229425 scopus 로고    scopus 로고
    • Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation
    • Sherer, T.B., Kim, J.H., Betarbet, R., Greenamyre, J.T., Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation. Exp. Neurol. 179 (2003), 9–16.
    • (2003) Exp. Neurol. , vol.179 , pp. 9-16
    • Sherer, T.B.1    Kim, J.H.2    Betarbet, R.3    Greenamyre, J.T.4
  • 46
    • 20744440945 scopus 로고    scopus 로고
    • Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo
    • Shih, A.Y., Imbeault, S., Barakauskas, V., Erb, H., Jiang, L., Li, P., Murphy, T.H., Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo. J. Biol. Chem. 280 (2005), 22925–22936.
    • (2005) J. Biol. Chem. , vol.280 , pp. 22925-22936
    • Shih, A.Y.1    Imbeault, S.2    Barakauskas, V.3    Erb, H.4    Jiang, L.5    Li, P.6    Murphy, T.H.7
  • 47
    • 84884583125 scopus 로고    scopus 로고
    • Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells
    • Steele, M.L., Fuller, S., Patel, M., Kersaitis, C., Ooi, L., Munch, G., Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells. Redox Biol. 1 (2013), 441–445.
    • (2013) Redox Biol. , vol.1 , pp. 441-445
    • Steele, M.L.1    Fuller, S.2    Patel, M.3    Kersaitis, C.4    Ooi, L.5    Munch, G.6
  • 48
    • 34548772935 scopus 로고    scopus 로고
    • Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2
    • Sun, Z., Zhang, S., Chan, J.Y., Zhang, D.D., Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. Mol. Cell Biol. 27 (2007), 6334–6349.
    • (2007) Mol. Cell Biol. , vol.27 , pp. 6334-6349
    • Sun, Z.1    Zhang, S.2    Chan, J.Y.3    Zhang, D.D.4
  • 49
    • 84866729431 scopus 로고    scopus 로고
    • Astrocyte activation: a key step in rotenone induced cytotoxicity and DNA damage
    • Swarnkar, S., Singh, S., Goswami, P., Mathur, R., Patro, I.K., Nath, C., Astrocyte activation: a key step in rotenone induced cytotoxicity and DNA damage. Neurochem. Res. 37 (2012), 2178–2189.
    • (2012) Neurochem. Res. , vol.37 , pp. 2178-2189
    • Swarnkar, S.1    Singh, S.2    Goswami, P.3    Mathur, R.4    Patro, I.K.5    Nath, C.6
  • 50
    • 84898667022 scopus 로고    scopus 로고
    • Both neurons and astrocytes exhibited tetrodotoxin-resistant metabotropic glutamate receptor-dependent spontaneous slow Ca2+ oscillations in striatum
    • Tamura, A., Yamada, N., Yaguchi, Y., Machida, Y., Mori, I., Osanai, M., Both neurons and astrocytes exhibited tetrodotoxin-resistant metabotropic glutamate receptor-dependent spontaneous slow Ca2+ oscillations in striatum. PLoS One, 9, 2014, e85351.
    • (2014) PLoS One , vol.9 , pp. e85351
    • Tamura, A.1    Yamada, N.2    Yaguchi, Y.3    Machida, Y.4    Mori, I.5    Osanai, M.6
  • 52
    • 15544365143 scopus 로고    scopus 로고
    • Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures
    • Testa, C.M., Sherer, T.B., Greenamyre, J.T., Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Brain Res. Mol. Brain Res. 134 (2005), 109–118.
    • (2005) Brain Res. Mol. Brain Res. , vol.134 , pp. 109-118
    • Testa, C.M.1    Sherer, T.B.2    Greenamyre, J.T.3
  • 54
    • 79955057180 scopus 로고    scopus 로고
    • The Nrf2/are pathway: a promising target to counteract mitochondrial dysfunction in Parkinson's disease
    • Tufekci, K.U., Civi Bayin, E., Genc, S., Genc, K., The Nrf2/are pathway: a promising target to counteract mitochondrial dysfunction in Parkinson's disease. Park. Dis., 2011, 2011, 314082.
    • (2011) Park. Dis. , vol.2011 , pp. 314082
    • Tufekci, K.U.1    Civi Bayin, E.2    Genc, S.3    Genc, K.4
  • 56
    • 84923291367 scopus 로고    scopus 로고
    • Modeling chemotherapeutic neurotoxicity with human induced pluripotent stem cell-derived neuronal cells
    • Wheeler, H.E., Wing, C., Delaney, S.M., Komatsu, M., Dolan, M.E., Modeling chemotherapeutic neurotoxicity with human induced pluripotent stem cell-derived neuronal cells. PLoS One, 10, 2015, e0118020.
    • (2015) PLoS One , vol.10 , pp. e0118020
    • Wheeler, H.E.1    Wing, C.2    Delaney, S.M.3    Komatsu, M.4    Dolan, M.E.5
  • 57
    • 84930958925 scopus 로고    scopus 로고
    • Neural differentiation of human pluripotent stem cells for nontherapeutic applications: toxicology, pharmacology, and in vitro disease modeling
    • Yap, M.S., Nathan, K.R., Yeo, Y., Lim, L.W., Poh, C.L., Richards, M., Lim, W.L., Othman, I., Heng, B.C., Neural differentiation of human pluripotent stem cells for nontherapeutic applications: toxicology, pharmacology, and in vitro disease modeling. Stem Cells Int., 2015, 105172.
    • (2015) Stem Cells Int. , pp. 105172
    • Yap, M.S.1    Nathan, K.R.2    Yeo, Y.3    Lim, L.W.4    Poh, C.L.5    Richards, M.6    Lim, W.L.7    Othman, I.8    Heng, B.C.9
  • 58
    • 84925541204 scopus 로고    scopus 로고
    • Sulfiredoxin-1 attenuates oxidative stress via Nrf2/ARE pathway and 2-Cys Prdxs after oxygen-glucose deprivation in astrocytes
    • Zhou, Y., Duan, S., Zhou, Y., Yu, S., Wu, J., Wu, X., Zhao, J., Zhao, Y., Sulfiredoxin-1 attenuates oxidative stress via Nrf2/ARE pathway and 2-Cys Prdxs after oxygen-glucose deprivation in astrocytes. J. Mol. Neurosci. 55 (2015), 941–950.
    • (2015) J. Mol. Neurosci. , vol.55 , pp. 941-950
    • Zhou, Y.1    Duan, S.2    Zhou, Y.3    Yu, S.4    Wu, J.5    Wu, X.6    Zhao, J.7    Zhao, Y.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.