Crosstalk between Ca2+ signaling and mitochondrial H2O2 is required for rotenone inhibition of mTOR signaling pathway leading to neuronal apoptosis

Oncotarget

Volumn 7, Issue 7, 2016, Pages 7534-7549

  Liu, Chunxiao ^a   Ye, Yangjing ^a   Zhou, Qian ^a   Zhang, Ruijie ^a   Zhang, Hai ^a   Liu, Wen ^a   Xu, Chong ^a   Liu, Lei ^b   Huang, Shile ^b   Chen, Long ^a  

^a NANJING NORMAL UNIVERSITY   (China)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Apoptosis; Calcium ion; CaMKII; H2O2; mTOR; Pathology; Rotenone

Indexed keywords

ANTIMYCIN A1; HYDROGEN PEROXIDE; MAMMALIAN TARGET OF RAPAMYCIN; ROTENONE; S6 KINASE; CALCIUM; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; INITIATION FACTOR; OXIDIZING AGENT; TARGET OF RAPAMYCIN KINASE; UNCOUPLING PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; ENZYME INHIBITION; NERVE CELL PLASTICITY; NEUROTOXICITY; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SYNAPTIC TRANSMISSION; SYNAPTOGENESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL PROLIFERATION; DRUG EFFECTS; METABOLISM; MITOCHONDRION; MOUSE; NERVE CELL; PATHOLOGY; PC12 CELL LINE; PHOSPHORYLATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL PROLIFERATION; CELLS, CULTURED; EUKARYOTIC INITIATION FACTORS; HYDROGEN PEROXIDE; MICE; MITOCHONDRIA; NEURONS; OXIDANTS; PC12 CELLS; PHOSPHORYLATION; RATS; ROTENONE; TOR SERINE-THREONINE KINASES; UNCOUPLING AGENTS;

EID: 84958817773     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7183     Document Type: Article

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