-
1
-
-
1642362625
-
Drug delivery systems: Entering the mainstream
-
Allen, T. M. & Cullis, P. R. Drug delivery systems: entering the mainstream. Science 303, 1818-1822 (2004).
-
(2004)
Science
, vol.303
, pp. 1818-1822
-
-
Allen, T.M.1
Cullis, P.R.2
-
2
-
-
80052704591
-
Predicting chemotherapy toxicity in older adults with cancer: A prospective multicenter study
-
Hurria, A. et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J. Clin. Oncol. 29, 3457-3465 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 3457-3465
-
-
Hurria, A.1
-
3
-
-
9244222261
-
Targeted cancer therapy
-
Sawyer, C. Targeted cancer therapy. Nature 432, 294-297 (2004).
-
(2004)
Nature
, vol.432
, pp. 294-297
-
-
Sawyer, C.1
-
4
-
-
79953271634
-
The evolving war on cancer
-
Haber, D. A., Gray, N. S. & Baselga, J. The evolving war on cancer. Cell 145, 19-24 (2011).
-
(2011)
Cell
, vol.145
, pp. 19-24
-
-
Haber, D.A.1
Gray, N.S.2
Baselga, J.3
-
5
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien, S. G. et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med. 348, 994-1004 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
-
6
-
-
67749122122
-
Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
-
Engelman, J. A. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat. Rev. Cancer 9, 550-562 (2009).
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 550-562
-
-
Engelman, J.A.1
-
7
-
-
36849067019
-
Nanocarriers as an emerging platform for cancer therapy
-
Peer, D. et al. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotech. 2, 751-760 (2007).
-
(2007)
Nat. Nanotech.
, vol.2
, pp. 751-760
-
-
Peer, D.1
-
8
-
-
84892650579
-
Cancer nanomedicine: From drug delivery to imaging
-
Chow, E. K. & Ho, D. Cancer nanomedicine: from drug delivery to imaging. Sci. Transl. Med. 5, 216rv4 (2013).
-
(2013)
Sci. Transl. Med.
, vol.5
, pp. 216rv4
-
-
Chow, E.K.1
Ho, D.2
-
9
-
-
0037362655
-
Effect of pegylation on pharmaceuticals
-
Harris, J. M. & Chess, R. B. Effect of pegylation on pharmaceuticals. Nat. Rev. Drug Discov. 2, 214-221 (2003).
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 214-221
-
-
Harris, J.M.1
Chess, R.B.2
-
10
-
-
84874169973
-
Minimal self peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles
-
Roderiguez, P. L. et al. Minimal self peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles. Science 339, 971-975 (2013).
-
(2013)
Science
, vol.339
, pp. 971-975
-
-
Roderiguez, P.L.1
-
11
-
-
84871730525
-
Synthetic nanoparticles functionalized with biomimetic leukocyte membrane possess cell-like functions
-
Parodi, A. et al. Synthetic nanoparticles functionalized with biomimetic leukocyte membrane possess cell-like functions. Nat. Nanotech. 8, 61-68 (2013).
-
(2013)
Nat. Nanotech.
, vol.8
, pp. 61-68
-
-
Parodi, A.1
-
12
-
-
84942901402
-
Nanoparticle biointerfacing by platelet membrane cloaking
-
Hu, C. J. et al. Nanoparticle biointerfacing by platelet membrane cloaking. Nature 526, 118-121 (2015).
-
(2015)
Nature
, vol.526
, pp. 118-121
-
-
Hu, C.J.1
-
13
-
-
40949127319
-
Therapeutic nanoparticles for drug delivery in cancer
-
Cho, K., Wang, X., Nie, S., Chen, Z. & Shin, D. M. Therapeutic nanoparticles for drug delivery in cancer. Clin. Cancer Res. 4, 1310-1316 (2008).
-
(2008)
Clin. Cancer Res.
, vol.4
, pp. 1310-1316
-
-
Cho, K.1
Wang, X.2
Nie, S.3
Chen, Z.4
Shin, D.M.5
-
14
-
-
33646582037
-
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
-
Farokhzad, O. C. et al. Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc. Natl Acad. Sci. USA 103, 6315-6320 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 6315-6320
-
-
Farokhzad, O.C.1
-
15
-
-
84855961163
-
Nanoparticle delivery of cancer drugs
-
Wang, A. Z., Langer, R. & Farokhzad, O. C. Nanoparticle delivery of cancer drugs. Annu. Rev. Med. 63, 185-198 (2012).
-
(2012)
Annu. Rev. Med.
, vol.63
, pp. 185-198
-
-
Wang, A.Z.1
Langer, R.2
Farokhzad, O.C.3
-
16
-
-
35148881028
-
Drug resistance and the solid tumor microenvironment
-
Trédan, O., Galmarini, C. M., Patel, K. & Tannock, I. F. Drug resistance and the solid tumor microenvironment. J. Natl Cancer Inst. 99, 1441-1454 (2007).
-
(2007)
J. Natl Cancer Inst.
, vol.99
, pp. 1441-1454
-
-
Trédan, O.1
Galmarini, C.M.2
Patel, K.3
Tannock, I.F.4
-
18
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet, P. & Jain, R. K. Angiogenesis in cancer and other diseases. Nature 407, 249-257 (2000).
-
(2000)
Nature
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
19
-
-
0033839080
-
Openings between defective endothelial cells explain tumor vessel leakiness
-
Hashizume, H. et al. Openings between defective endothelial cells explain tumor vessel leakiness. Am. J. Pathol. 156, 1363-1380 (2000).
-
(2000)
Am. J. Pathol.
, vol.156
, pp. 1363-1380
-
-
Hashizume, H.1
-
20
-
-
0022858683
-
A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
-
Matsumura, Y. & Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46, 6387-6392 (1986).
-
(1986)
Cancer Res.
, vol.46
, pp. 6387-6392
-
-
Matsumura, Y.1
Maeda, H.2
-
21
-
-
84876534007
-
Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology
-
Prabhakar, U. et al. Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology. Cancer Res. 73, 2412-2417 (2013).
-
(2013)
Cancer Res.
, vol.73
, pp. 2412-2417
-
-
Prabhakar, U.1
-
22
-
-
84941066997
-
Principles of nanoparticle design for overcoming biological barriers to drug delivery
-
Blanco, E., Shen, H. & Ferrari, M. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat. Biotechnol. 33, 941-951 (2015).
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 941-951
-
-
Blanco, E.1
Shen, H.2
Ferrari, M.3
-
23
-
-
84959421064
-
Tailoring nanoparticle designs to target cancer based on tumor pathophysiology
-
Sykes, E. A. et al. Tailoring nanoparticle designs to target cancer based on tumor pathophysiology. Proc. Natl Acad. Sci. USA 113, E1142-E1151 (2016).
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. E1142-E1151
-
-
Sykes, E.A.1
-
24
-
-
66449116301
-
Mediating tumor targeting efficiency of nanoparticles through design
-
Perrault, S. D., Walkey, C., Jennings, T., Fischer, H. C. & Chan, W. C. W. Mediating tumor targeting efficiency of nanoparticles through design. Nano Lett. 9, 1909-1915 (2009).
-
(2009)
Nano Lett.
, vol.9
, pp. 1909-1915
-
-
Perrault, S.D.1
Walkey, C.2
Jennings, T.3
Fischer, H.C.4
Chan, W.C.W.5
-
25
-
-
36749061351
-
Advances and challenges of nanotechnology-based drug delivery systems
-
Jiang, W., Kim, B. Y. S., Rutka, J. T. & Chan, W. C. W. Advances and challenges of nanotechnology-based drug delivery systems. Expert Opin. Drug Deliv. 4, 621-633 (2007).
-
(2007)
Expert Opin. Drug Deliv.
, vol.4
, pp. 621-633
-
-
Jiang, W.1
Kim, B.Y.S.2
Rutka, J.T.3
Chan, W.C.W.4
-
26
-
-
84997831561
-
Breaking down the barriers to precision cancer nanomedicine
-
von Roemeling, C. A., Jiang, W., Chan, C. K., Weissman, I. L. & Kim, B. Y. S. Breaking down the barriers to precision cancer nanomedicine. Trends Biotechnol. 35, 159-171 (2017).
-
(2017)
Trends Biotechnol.
, vol.35
, pp. 159-171
-
-
Von Roemeling, C.A.1
Jiang, W.2
Chan, C.K.3
Weissman, I.L.4
Kim, B.Y.S.5
-
27
-
-
79952291790
-
Multistage nanoparticle delivery system for deep penetration into tumor tissue
-
Wong, C. et al. Multistage nanoparticle delivery system for deep penetration into tumor tissue. Proc. Natl Acad. Sci. USA 108, 2426-2431 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 2426-2431
-
-
Wong, C.1
-
28
-
-
85016350463
-
Analysis of nanoparticle delivery to tumours
-
Wilhelm, S. et al. Analysis of nanoparticle delivery to tumours. Nat. Rev. Mater. 1, 16014 (2016).
-
(2016)
Nat. Rev. Mater.
, vol.1
, pp. 16014
-
-
Wilhelm, S.1
-
29
-
-
84982136636
-
Mechanism of hard-nanomaterial clearance by the liver
-
Tsoi, K. M. et al. Mechanism of hard-nanomaterial clearance by the liver. Nat. Mater. 15, 1212-1221 (2016).
-
(2016)
Nat. Mater.
, vol.15
, pp. 1212-1221
-
-
Tsoi, K.M.1
-
30
-
-
39649115201
-
Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
-
De Jong, W. H. et al. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 29, 1912-1919 (2008).
-
(2008)
Biomaterials
, vol.29
, pp. 1912-1919
-
-
De Jong, W.H.1
-
31
-
-
79952008706
-
The effect of surface charge on in vivo distribution of PEG-oligocholic acid based micellar nanoparticles
-
Xiao, K. et al. The effect of surface charge on in vivo distribution of PEG-oligocholic acid based micellar nanoparticles. Biomaterials 32, 3435-3446 (2011).
-
(2011)
Biomaterials
, vol.32
, pp. 3435-3446
-
-
Xiao, K.1
-
32
-
-
84885483569
-
Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology
-
Tenzer, S. et al. Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology. Nat. Nanotech. 8, 772-781 (2013).
-
(2013)
Nat. Nanotech.
, vol.8
, pp. 772-781
-
-
Tenzer, S.1
-
33
-
-
33847789142
-
Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles
-
Cedervall, T. et al. Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles. Proc. Natl Acad. Sci. USA 104, 2050-2055 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 2050-2055
-
-
Cedervall, T.1
-
34
-
-
84856436072
-
Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake
-
Walkey, C. D., Olsen, J. B., Guo, H., Emili, A. & Chan, W. C. W. Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake. J. Am. Chem. Soc. 134, 2139-2147 (2012).
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 2139-2147
-
-
Walkey, C.D.1
Olsen, J.B.2
Guo, H.3
Emili, A.4
Chan, W.C.W.5
-
35
-
-
84896928606
-
Protein corona fingerprinting predicts the cellular interactions of gold and silver nanoparticles
-
Walkey, C. D. et al. Protein corona fingerprinting predicts the cellular interactions of gold and silver nanoparticles. ACS Nano 8, 2439-2455 (2014).
-
(2014)
ACS Nano
, vol.8
, pp. 2439-2455
-
-
Walkey, C.D.1
-
36
-
-
67649491055
-
Understanding biophysicochemical interactions at the nano-bio interface
-
Nel, A. E. et al. Understanding biophysicochemical interactions at the nano-bio interface. Nat. Mater. 8, 543-557 (2009).
-
(2009)
Nat. Mater.
, vol.8
, pp. 543-557
-
-
Nel, A.E.1
-
37
-
-
84970029114
-
Surface modification of nanoparticles enables selective evasion of phagocytic clearance by distinct macrophage phenotypes
-
Qie, Y. et al. Surface modification of nanoparticles enables selective evasion of phagocytic clearance by distinct macrophage phenotypes. Sci. Rep. 6, 26269 (2016).
-
(2016)
Sci. Rep.
, vol.6
, pp. 26269
-
-
Qie, Y.1
-
38
-
-
84865578808
-
Scavenger receptor mediated endocytosis of silver nanoparticles into J774A.1 macrophages is heterogeneous
-
Wang, H., Wu, L. & Reinhard, B. M. Scavenger receptor mediated endocytosis of silver nanoparticles into J774A.1 macrophages is heterogeneous. ACS Nano 6, 7122-7132 (2012).
-
(2012)
ACS Nano
, vol.6
, pp. 7122-7132
-
-
Wang, H.1
Wu, L.2
Reinhard, B.M.3
-
39
-
-
0036597855
-
EORTC 10968: A phase i clinical and pharmacokinetic study of polyethylene glycol liposomal doxorubicin (Caelyx, Doxil) at a 6-week interval in patients with metastatic breast cancer
-
Hamilton, A. et al. EORTC 10968: a phase I clinical and pharmacokinetic study of polyethylene glycol liposomal doxorubicin (Caelyx, Doxil) at a 6-week interval in patients with metastatic breast cancer. European Organisation for Research and Treatment of Cancer. Ann. Oncol. 13, 910-918 (2002).
-
(2002)
European Organisation for Research and Treatment of Cancer. Ann. Oncol.
, vol.13
, pp. 910-918
-
-
Hamilton, A.1
-
40
-
-
84958078423
-
Protein adsorption is required for stealth effect of poly(ethyleneglycol)-and poly(phosphoester)-coated nanocarriers
-
Schottler, S. et al. Protein adsorption is required for stealth effect of poly(ethyleneglycol)-and poly(phosphoester)-coated nanocarriers. Nat. Nanotech. 11, 372-377 (2016).
-
(2016)
Nat. Nanotech.
, vol.11
, pp. 372-377
-
-
Schottler, S.1
-
41
-
-
79960583505
-
Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform
-
Hu, C. M. et al. Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform. Proc. Natl Acad. Sci. USA 108, 10980-10985 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 10980-10985
-
-
Hu, C.M.1
-
42
-
-
84938125681
-
Erythrocyte membrane-enveloped polymeric nanoparticles as nanovaccine for induction of antitumor immunity against melanoma
-
Guo, Y. et al. Erythrocyte membrane-enveloped polymeric nanoparticles as nanovaccine for induction of antitumor immunity against melanoma. ACS Nano 9, 6918-6933 (2015).
-
(2015)
ACS Nano
, vol.9
, pp. 6918-6933
-
-
Guo, Y.1
-
43
-
-
84969883853
-
Biomimetic proteolipid vesicles for targeting inflamed tissues
-
Molinaro, R. et al. Biomimetic proteolipid vesicles for targeting inflamed tissues. Nat. Mater. 15, 1037-1046 (2016).
-
(2016)
Nat. Mater.
, vol.15
, pp. 1037-1046
-
-
Molinaro, R.1
-
44
-
-
84982128186
-
Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions
-
Felfoul, O. et al. Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions. Nat. Nanotech. 11, 941-947 (2016).
-
(2016)
Nat. Nanotech.
, vol.11
, pp. 941-947
-
-
Felfoul, O.1
-
45
-
-
36248951671
-
Macrophage tolerance: CD47-SIRP-mediated signals matter
-
Takizawa, H. & Manz, M. G. Macrophage tolerance: CD47-SIRP-mediated signals matter. Nat. Immunol. 8, 1287-1289 (2007).
-
(2007)
Nat. Immunol.
, vol.8
, pp. 1287-1289
-
-
Takizawa, H.1
Manz, M.G.2
-
46
-
-
84886794929
-
The immune system and kidney disease: Basic concepts and clinical implications
-
Kurts, C., Panzer, U., Anders, H. J. & Rees, A. J. The immune system and kidney disease: basic concepts and clinical implications. Nat. Rev. Immunol. 13, 738-753 (2013).
-
(2013)
Nat. Rev. Immunol.
, vol.13
, pp. 738-753
-
-
Kurts, C.1
Panzer, U.2
Anders, H.J.3
Rees, A.J.4
-
47
-
-
0034799334
-
Structural determinants of glomerular permeability
-
Deen, W. M., Lazzara, M. J. & Meyers, B. D. Structural determinants of glomerular permeability. Am. J. Physiol. Renal Physiol. 281, F579-F596 (2001).
-
(2001)
Am. J. Physiol. Renal Physiol.
, vol.281
, pp. F579-F596
-
-
Deen, W.M.1
Lazzara, M.J.2
Meyers, B.D.3
-
48
-
-
35148864458
-
Renal clearance of quantum dots
-
Choi, H. S. et al. Renal clearance of quantum dots. Nat. Biotechnol. 25, 1165-1170 (2007).
-
(2007)
Nat. Biotechnol.
, vol.25
, pp. 1165-1170
-
-
Choi, H.S.1
-
49
-
-
84890318341
-
Renal clearable inorganic nanoparticles: A new frontier of bionanotechnology
-
December
-
Liu, J. Y. et al. Renal clearable inorganic nanoparticles: a new frontier of bionanotechnology. Mater. Today 16, 477-486 (December, 2013).
-
(2013)
Mater. Today
, vol.16
, pp. 477-486
-
-
Liu, J.Y.1
-
50
-
-
0036738495
-
Cancer therapy and renal injury
-
Schrier, R. W. Cancer therapy and renal injury. J. Clin. Invest. 110, 743-745 (2002).
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 743-745
-
-
Schrier, R.W.1
-
51
-
-
0033755180
-
The blood-brain and blood-tumor barriers: A review of strategies for increasing drug delivery
-
Groothuis, D. R. The blood-brain and blood-tumor barriers: a review of strategies for increasing drug delivery. Neuro. Oncol. 2, 45-59 (2000).
-
(2000)
Neuro. Oncol.
, vol.2
, pp. 45-59
-
-
Groothuis, D.R.1
-
52
-
-
79951778173
-
Drug transporters, the blood-testis barrier, and spermatogenesis
-
Su, L., Mruk, D. D. & Cheng, C. Y. Drug transporters, the blood-testis barrier, and spermatogenesis. J. Endocrinol. 208, 207-223 (2011).
-
(2011)
J. Endocrinol.
, vol.208
, pp. 207-223
-
-
Su, L.1
Mruk, D.D.2
Cheng, C.Y.3
-
53
-
-
81755172852
-
Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging
-
Koffie, R. M. et al. Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging. Proc. Natl Acad. Sci. USA 108, 18837-18842 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 18837-18842
-
-
Koffie, R.M.1
-
54
-
-
78149432751
-
Human serum albumin nanoparticles modified with apolipoprotein A-I cross the blood-brain barrier and enter the rodent brain
-
Zensi, A. et al. Human serum albumin nanoparticles modified with apolipoprotein A-I cross the blood-brain barrier and enter the rodent brain. J. Drug Target. 18, 842-848 (2010).
-
(2010)
J. Drug Target.
, vol.18
, pp. 842-848
-
-
Zensi, A.1
-
55
-
-
84555178913
-
Treating metastatic cancer with nanotechnology
-
Schroeder, A. et al. Treating metastatic cancer with nanotechnology. Nat. Rev. Cancer 12, 39-50 (2012).
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 39-50
-
-
Schroeder, A.1
-
56
-
-
84975090470
-
Clinical trial of blood-brain barrier disruption by pulsed ultrasound
-
Carpentier, A. et al. Clinical trial of blood-brain barrier disruption by pulsed ultrasound. Sci. Transl. Med. 8, 343re2 (2016).
-
(2016)
Sci. Transl. Med.
, vol.8
, pp. 343re2
-
-
Carpentier, A.1
-
57
-
-
84873268296
-
The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo
-
Maeda, H., Nakamura, H. & Fang, J. The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo. Adv. Drug Deliv. Rev. 65, 71-79 (2013).
-
(2013)
Adv. Drug Deliv. Rev.
, vol.65
, pp. 71-79
-
-
Maeda, H.1
Nakamura, H.2
Fang, J.3
-
58
-
-
0032516078
-
Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
-
Hobbs, S. K. et al. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc. Natl Acad. Sci. USA 95, 4607-4612 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 4607-4612
-
-
Hobbs, S.K.1
-
59
-
-
84886310583
-
Strategies for advancing cancer nanomedicine
-
Chauhan, V. P. & Jain, R. K. Strategies for advancing cancer nanomedicine. Nat. Mater. 12, 958-962 (2013).
-
(2013)
Nat. Mater.
, vol.12
, pp. 958-962
-
-
Chauhan, V.P.1
Jain, R.K.2
-
60
-
-
1542320497
-
Pathology: Cancer cells compress intratumour vessels
-
Padera, T. P. et al. Pathology: cancer cells compress intratumour vessels. Nature 427, 695 (2004).
-
(2004)
Nature
, vol.427
, pp. 695
-
-
Padera, T.P.1
-
61
-
-
84983087840
-
Nanomedicine strategies to overcome the pathophysiological barriers of pancreatic cancer
-
Adiseshaiah, P. P., Crist, R. M., Hook, S. S. & McNeil, S. E. Nanomedicine strategies to overcome the pathophysiological barriers of pancreatic cancer. Nat. Rev. Clin. Oncol. 13, 750-765 (2016).
-
(2016)
Nat. Rev. Clin. Oncol.
, vol.13
, pp. 750-765
-
-
Adiseshaiah, P.P.1
Crist, R.M.2
Hook, S.S.3
McNeil, S.E.4
-
62
-
-
84874693196
-
The tumor microenvironment at a glance
-
Balkwill, F. R., Capasso, M. & Hagemann, T. The tumor microenvironment at a glance. J. Cell Sci. 125, 5591-5596 (2012).
-
(2012)
J. Cell Sci.
, vol.125
, pp. 5591-5596
-
-
Balkwill, F.R.1
Capasso, M.2
Hagemann, T.3
-
63
-
-
0036781811
-
Ligand-targeted therapeutics in anticancer therapy
-
Allen, T. M. Ligand-targeted therapeutics in anticancer therapy. Nat. Rev. Cancer 2, 750-763 (2002).
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 750-763
-
-
Allen, T.M.1
-
64
-
-
58149277700
-
Biodegradable quantum dot nanocomposites enable live cell labeling and imaging of cytoplasmic targets
-
Kim, B. Y. S. et al. Biodegradable quantum dot nanocomposites enable live cell labeling and imaging of cytoplasmic targets. Nano Lett. 8, 3887-3892 (2008).
-
(2008)
Nano Lett.
, vol.8
, pp. 3887-3892
-
-
Kim, B.Y.S.1
-
65
-
-
3543022686
-
In vivo cancer targeting and imaging with semiconductor quantum dots
-
Gao, X., Cui, Y., Levenson, R. M., Chung, L. W. K. & Nie, S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat. Biotechnol. 22, 969-976 (2004).
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 969-976
-
-
Gao, X.1
Cui, Y.2
Levenson, R.M.3
Chung, L.W.K.4
Nie, S.5
-
66
-
-
73849140878
-
Design considerations for tumour-targeted nanoparticles
-
Choi, H. S. et al. Design considerations for tumour-targeted nanoparticles. Nat. Nanotech. 5, 42-47 (2010).
-
(2010)
Nat. Nanotech.
, vol.5
, pp. 42-47
-
-
Choi, H.S.1
-
67
-
-
33745295845
-
Combinatorial chemistry identifies high-affinity peptidomimetics against ?4?1 integrin for in vivo tumor imaging
-
Peng, L. et al. Combinatorial chemistry identifies high-affinity peptidomimetics against ?4?1 integrin for in vivo tumor imaging. Nat. Chem. Biol. 2, 381-389 (2006).
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 381-389
-
-
Peng, L.1
-
68
-
-
40449122796
-
Nanoparticle-mediated cellular response is size-dependent
-
Jiang, W., Kim, B. Y. S., Rutka, J. T. & Chan, W. C. W. Nanoparticle-mediated cellular response is size-dependent. Nat. Nanotech. 3, 145-150 (2008).
-
(2008)
Nat. Nanotech.
, vol.3
, pp. 145-150
-
-
Jiang, W.1
Kim, B.Y.S.2
Rutka, J.T.3
Chan, W.C.W.4
-
69
-
-
84858785688
-
Antibody therapy of cancer
-
Scott, A. M., Wolchok, J. D. & Old, L. J. Antibody therapy of cancer. Nat. Rev. Cancer 12, 278-287 (2012).
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 278-287
-
-
Scott, A.M.1
Wolchok, J.D.2
Old, L.J.3
-
70
-
-
77951529848
-
Therapeutic antibodies for autoimmunity and inflammation
-
Chan, A. C. & Carter, P. J. Therapeutic antibodies for autoimmunity and inflammation. Nat. Rev. Immunol. 10, 301-316 (2010).
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 301-316
-
-
Chan, A.C.1
Carter, P.J.2
-
71
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem, E. et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N. Engl. J. Med. 360, 1408-1417 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1408-1417
-
-
Van Cutsem, E.1
-
72
-
-
34347395733
-
Trastuzumab-mechanism of action and use in clinical practice
-
Hudis, C. A. Trastuzumab-mechanism of action and use in clinical practice. N. Engl. J. Med. 357, 39-51 (2007).
-
(2007)
N. Engl. J. Med.
, vol.357
, pp. 39-51
-
-
Hudis, C.A.1
-
73
-
-
49349095724
-
Monoclonal antibody therapy for B-cell non-Hodgkin's lymphoma
-
Cheson, B. D. & Leonard, J. P. Monoclonal antibody therapy for B-cell non-Hodgkin's lymphoma. N. Engl. J. Med. 359, 613-626 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 613-626
-
-
Cheson, B.D.1
Leonard, J.P.2
-
74
-
-
84868520609
-
Trastuzumab emtansine for HER2-positive advanced breast cancer
-
Verma, S. et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N. Engl. J. Med. 367, 1783-1791 (2012).
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 1783-1791
-
-
Verma, S.1
-
75
-
-
0032975042
-
Randomized phase II study of BR96-doxorubicin conjugate in patients with metastatic breast cancer
-
Tolcher, A. W. et al. Randomized phase II study of BR96-doxorubicin conjugate in patients with metastatic breast cancer. J. Clin. Oncol. 17, 478-484 (1999).
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 478-484
-
-
Tolcher, A.W.1
-
76
-
-
78650196945
-
Nanomedicine
-
Kim, B. Y. S., Rutka, J. T. & Chan, W. C. W. Nanomedicine. N. Engl. J. Med. 363, 2434-2443 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 2434-2443
-
-
Kim, B.Y.S.1
Rutka, J.T.2
Chan, W.C.W.3
-
77
-
-
20444412646
-
Therapeutic targeting of the tumor microenvironment
-
Joyce, J. A. Therapeutic targeting of the tumor microenvironment. Cancer Cell 7, 513-520 (2005).
-
(2005)
Cancer Cell
, vol.7
, pp. 513-520
-
-
Joyce, J.A.1
-
78
-
-
0032535999
-
Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
-
Arap, W., Pasqualini, R. & Ruoslahti, E. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 279, 377-380 (1998).
-
(1998)
Science
, vol.279
, pp. 377-380
-
-
Arap, W.1
Pasqualini, R.2
Ruoslahti, E.3
-
79
-
-
70749103751
-
Tissue-penetrating delivery of compounds and nanoparticles into tumors
-
Sugahara, K. N. et al. Tissue-penetrating delivery of compounds and nanoparticles into tumors. Cancer Cell 16, 510-520 (2009).
-
(2009)
Cancer Cell
, vol.16
, pp. 510-520
-
-
Sugahara, K.N.1
-
80
-
-
77949762340
-
Targeting of drugs and nanoparticles to tumors
-
Ruoslahti, E., Bhatia, S. N. & Sailor, M. J. Targeting of drugs and nanoparticles to tumors. J. Cell. Biol. 188, 759-768 (2010).
-
(2010)
J. Cell. Biol.
, vol.188
, pp. 759-768
-
-
Ruoslahti, E.1
Bhatia, S.N.2
Sailor, M.J.3
-
81
-
-
70349482671
-
C-end rule peptides mediate neuropilin?1?Dependent cell, vascular, and tissue penetration
-
Teesalu, T., Sugahara, K. N., Kotamraju, V. R. & Ruoslahti, E. C-end rule peptides mediate neuropilin?1?dependent cell, vascular, and tissue penetration. Proc. Natl Acad. Sci. USA 106, 16157-16162 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 16157-16162
-
-
Teesalu, T.1
Sugahara, K.N.2
Kotamraju, V.R.3
Ruoslahti, E.4
-
82
-
-
33846545130
-
Biomimetic amplification of nanoparticle homing to tumors
-
Simberg, D. et al. Biomimetic amplification of nanoparticle homing to tumors. Proc. Natl Acad. Sci. USA 104, 932-936 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 932-936
-
-
Simberg, D.1
-
83
-
-
67349253388
-
Targeted lipid-coated nanoparticles: Delivery of tumor necrosis factor-functionalized particles to tumor cells
-
Messerschmidt, S. K. et al. Targeted lipid-coated nanoparticles: delivery of tumor necrosis factor-functionalized particles to tumor cells. J. Control. Release 137, 69-77 (2009).
-
(2009)
J. Control. Release
, vol.137
, pp. 69-77
-
-
Messerschmidt, S.K.1
-
84
-
-
84893019819
-
Imaging macrophages with nanoparticles
-
Weissleder, R., Nahrendorf, M. & Pittet, M. J. Imaging macrophages with nanoparticles. Nat. Mater. 13, 125-138 (2014).
-
(2014)
Nat. Mater.
, vol.13
, pp. 125-138
-
-
Weissleder, R.1
Nahrendorf, M.2
Pittet, M.J.3
-
85
-
-
84896716175
-
Targeting fibronectins of glioma extracellular matrix by CLT1 peptide-conjugated nanoparticles
-
Zhang, B. et al. Targeting fibronectins of glioma extracellular matrix by CLT1 peptide-conjugated nanoparticles. Biomaterials 35, 4088-4098 (2014).
-
(2014)
Biomaterials
, vol.35
, pp. 4088-4098
-
-
Zhang, B.1
-
86
-
-
79957894276
-
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
-
Carmeliet, P. & Jain, R. K. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat. Rev. Drug. Discov. 10, 417-427 (2011).
-
(2011)
Nat. Rev. Drug. Discov.
, vol.10
, pp. 417-427
-
-
Carmeliet, P.1
Jain, R.K.2
-
87
-
-
84863655863
-
Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
-
Chauhan, V. P. et al. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nat. Nanotech. 7, 383-388 (2012).
-
(2012)
Nat. Nanotech.
, vol.7
, pp. 383-388
-
-
Chauhan, V.P.1
-
88
-
-
84942265260
-
Remodeling tumor vasculature to enhance delivery of intermediate-sized nanoparticles
-
Jiang, W., Huang, Y. H., An, Y. & Kim, B. Y. S. Remodeling tumor vasculature to enhance delivery of intermediate-sized nanoparticles. ACS Nano 9, 8689-8696 (2015).
-
(2015)
ACS Nano
, vol.9
, pp. 8689-8696
-
-
Jiang, W.1
Huang, Y.H.2
An, Y.3
Kim, B.Y.S.4
-
89
-
-
83555166219
-
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
-
Cabral, H. et al. Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat. Nanotech. 6, 815-823 (2011).
-
(2011)
Nat. Nanotech.
, vol.6
, pp. 815-823
-
-
Cabral, H.1
-
90
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll, D. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12, 252-264 (2012).
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.1
-
91
-
-
84929481480
-
Pembrolizumab for the treatment of non?Small?Cell lung cancer
-
Garon, E. B. et al. Pembrolizumab for the treatment of non?small?cell lung cancer. N. Engl. J. Med. 372, 2018-2028 (2015).
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 2018-2028
-
-
Garon, E.B.1
-
92
-
-
84946607195
-
Nivolumab versus everolimus in advanced renal-cell carcinoma
-
Motzer, R. J. et al. Nivolumab versus everolimus in advanced renal-cell carcinoma. N. Engl. J. Med. 373, 1803-1813 (2015).
-
(2015)
N. Engl. J. Med.
, vol.373
, pp. 1803-1813
-
-
Motzer, R.J.1
-
93
-
-
84936147067
-
Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
-
Larkin, J. et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N. Engl. J. Med. 373, 23-34 (2015).
-
(2015)
N. Engl. J. Med.
, vol.373
, pp. 23-34
-
-
Larkin, J.1
-
94
-
-
84976511909
-
PD-1 blockade with pembrolizumab in advanced Merkel cell carcinoma
-
Nghiem, P. T. et al. PD-1 blockade with pembrolizumab in advanced Merkel cell carcinoma. N. Engl. J. Med. 374, 2542-2552 (2016).
-
(2016)
N. Engl. J. Med.
, vol.374
, pp. 2542-2552
-
-
Nghiem, P.T.1
-
95
-
-
84941655113
-
Cancer immunotherapy: Harnessing the immune system to battle cancer
-
Yang, Y. Cancer immunotherapy: harnessing the immune system to battle cancer. J. Clin. Invest. 125, 3335-3337 (2015).
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 3335-3337
-
-
Yang, Y.1
-
96
-
-
84858780815
-
Cancer immunotherapy via dendritic cells
-
Palucka, K. & Banchereau, J. Cancer immunotherapy via dendritic cells. Nat. Rev. Cancer 12, 265-277 (2012).
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 265-277
-
-
Palucka, K.1
Banchereau, J.2
-
97
-
-
80755180853
-
Beginnings of a good apoptotic meal: The find-me and eat-me signaling pathways
-
Ravichandran, K. S. Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways. Immunity 35, 445-455 (2011).
-
(2011)
Immunity
, vol.35
, pp. 445-455
-
-
Ravichandran, K.S.1
-
98
-
-
78650664067
-
Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47
-
Chao, M. P. et al. Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47. Sci. Transl. Med. 2, 63ra94 (2010).
-
(2010)
Sci. Transl. Med.
, vol.2
, pp. 63ra94
-
-
Chao, M.P.1
-
99
-
-
0034604029
-
A receptor for phosphatidylserine-specific clearance of apoptotic cells
-
Fadok, V. A. et al. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature 405, 85-90 (2000).
-
(2000)
Nature
, vol.405
, pp. 85-90
-
-
Fadok, V.A.1
-
100
-
-
84951310757
-
NK cells and cancer: You can teach innate cells new tricks
-
Morvan, M. G. & Lanier, L. L. NK cells and cancer: you can teach innate cells new tricks. Nat. Rev. Cancer 16, 7-19 (2016).
-
(2016)
Nat. Rev. Cancer
, vol.16
, pp. 7-19
-
-
Morvan, M.G.1
Lanier, L.L.2
-
101
-
-
67650646082
-
CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis
-
Jaiswal, S. et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell 138, 271-285 (2009).
-
(2009)
Cell
, vol.138
, pp. 271-285
-
-
Jaiswal, S.1
-
102
-
-
84860174226
-
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
-
Willingham, S. B. et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc. Natl Acad. Sci. USA 109, 6662-6667 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 6662-6667
-
-
Willingham, S.B.1
-
103
-
-
40849139246
-
Inhibition of self engulfment through deactivation of myosin-II at the phagocytic synapse between human cells
-
Tsai, R. K. & Discher, D. E. Inhibition of self engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. J. Cell Biol. 180, 989-1003 (2008).
-
(2008)
J. Cell Biol.
, vol.180
, pp. 989-1003
-
-
Tsai, R.K.1
Discher, D.E.2
-
104
-
-
84928774156
-
The future of immune checkpoint therapy
-
Sharma, P. & Allison, J. P. The future of immune checkpoint therapy. Science 348, 56-61 (2015).
-
(2015)
Science
, vol.348
, pp. 56-61
-
-
Sharma, P.1
Allison, J.P.2
-
105
-
-
84859157752
-
Tim-3, a negative regulator of anti-tumor immunity
-
Anderson, A. C. Tim-3, a negative regulator of anti-tumor immunity. Curr. Opin. Immunol. 24, 213-216 (2012).
-
(2012)
Curr. Opin. Immunol.
, vol.24
, pp. 213-216
-
-
Anderson, A.C.1
-
106
-
-
14944368161
-
MHC class i down-regulation: Tumour escape from immune surveillance?
-
Bubeník, J. MHC class I down-regulation: tumour escape from immune surveillance? Int. J. Oncol. 25, 487-491 (2004).
-
(2004)
Int. J. Oncol.
, vol.25
, pp. 487-491
-
-
Bubeník, J.1
-
107
-
-
84941695057
-
Myeloid-derived suppressor cells in the tumor microenvironment: Expect the unexpected
-
Marvel, D. & Gabrilovich, D. I. Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. J. Clin. Invest. 125, 3356-3364 (2015).
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 3356-3364
-
-
Marvel, D.1
Gabrilovich, D.I.2
-
108
-
-
84944045501
-
Tumor-expressed IDO recruits and activates MDSCs in a Treg-dependent manner
-
Holmgaard, R. B. et al. Tumor-expressed IDO recruits and activates MDSCs in a Treg-dependent manner. Cell Rep. 13, 412-424 (2015).
-
(2015)
Cell Rep.
, vol.13
, pp. 412-424
-
-
Holmgaard, R.B.1
-
109
-
-
84989172165
-
Ionic immune suppression within the tumour microenvironment limits T cell effector function
-
Eil, R. et al. Ionic immune suppression within the tumour microenvironment limits T cell effector function. Nature 537, 539-543 (2016).
-
(2016)
Nature
, vol.537
, pp. 539-543
-
-
Eil, R.1
-
110
-
-
77956976681
-
Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm
-
Biswas, S. K. & Mantovani, A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat. Immunol. 11, 889-896 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 889-896
-
-
Biswas, S.K.1
Mantovani, A.2
-
111
-
-
84863594742
-
Cellular constituents of immune escape within the tumor microenvironment
-
Kerkar, S. P. & Restifo, N. P. Cellular constituents of immune escape within the tumor microenvironment. Cancer Res. 72, 3125-3130 (2012).
-
(2012)
Cancer Res.
, vol.72
, pp. 3125-3130
-
-
Kerkar, S.P.1
Restifo, N.P.2
-
112
-
-
84975832642
-
Systemic RNA delivery to dendritic cells exploits antiviral defense for cancer immunotherapy
-
Kranz, L. M. et al. Systemic RNA delivery to dendritic cells exploits antiviral defense for cancer immunotherapy. Nature 534, 396-401 (2016).
-
(2016)
Nature
, vol.534
, pp. 396-401
-
-
Kranz, L.M.1
-
113
-
-
84973866282
-
RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction
-
Sager, H. B. et al. RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction. Sci. Transl. Med. 8, 342ra80 (2016).
-
(2016)
Sci. Transl. Med.
, vol.8
, pp. 342ra80
-
-
Sager, H.B.1
-
114
-
-
14644439267
-
Cancer nanotechnology: Opportunities and challenges
-
Ferrari, M. Cancer nanotechnology: opportunities and challenges. Nat. Rev. Cancer 5, 161-171 (2005).
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 161-171
-
-
Ferrari, M.1
-
115
-
-
42649132499
-
Protein nanoparticles as drug carriers in clinical medicine
-
Hawkin, M. J., Soon-Shiong, P. & Desai, N. Protein nanoparticles as drug carriers in clinical medicine. Adv. Drug Deliv. Rev. 60, 876-885 (2008).
-
(2008)
Adv. Drug Deliv. Rev.
, vol.60
, pp. 876-885
-
-
Hawkin, M.J.1
Soon-Shiong, P.2
Desai, N.3
-
116
-
-
84929481482
-
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
-
Postow, M. A. et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N. Engl. J. Med. 372, 2006-2017 (2015).
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 2006-2017
-
-
Postow, M.A.1
-
117
-
-
84932628341
-
PD-1 blockade in tumors with mismatch-repair deficiency
-
Le, D. T. et al. PD-1 blockade in tumors with mismatch-repair deficiency. N. Engl. J. Med. 372, 2509-2520 (2015).
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
-
118
-
-
84925221855
-
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
-
Ansell, S. M. et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N. Engl. J. Med. 372, 311-319 (2015).
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 311-319
-
-
Ansell, S.M.1
-
119
-
-
84884676871
-
Generation of effector memory T cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccination
-
Li, A. V. et al. Generation of effector memory T cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccination. Sci. Transl. Med. 5, 204ra130 (2013).
-
(2013)
Sci. Transl. Med.
, vol.5
, pp. 204ra130
-
-
Li, A.V.1
-
120
-
-
80455164555
-
A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy
-
Cho, N. H. et al. A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy. Nat. Nanotech. 6, 675-682 (2011).
-
(2011)
Nat. Nanotech.
, vol.6
, pp. 675-682
-
-
Cho, N.H.1
-
121
-
-
79951899834
-
Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses
-
Moon, J. J. et al. Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses. Nat. Mater. 10, 243-251 (2011).
-
(2011)
Nat. Mater.
, vol.10
, pp. 243-251
-
-
Moon, J.J.1
-
122
-
-
84960114076
-
In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer
-
Lizotte, P. H. et al. In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer. Nat. Nanotech. 11, 295-303 (2016).
-
(2016)
Nat. Nanotech.
, vol.11
, pp. 295-303
-
-
Lizotte, P.H.1
-
123
-
-
80455154958
-
Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response
-
Li, H., Li, Y., Jiao, J. & Hu, H. M. Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response. Nat. Nanotech. 6, 645-650 (2011).
-
(2011)
Nat. Nanotech.
, vol.6
, pp. 645-650
-
-
Li, H.1
Li, Y.2
Jiao, J.3
Hu, H.M.4
-
124
-
-
0033619915
-
Molecular mimicry and autoimmunity
-
Albert, L. J. & Inman, R. D. Molecular mimicry and autoimmunity. N. Engl. J. Med. 341, 2068-2074 (1999).
-
(1999)
N. Engl. J. Med.
, vol.341
, pp. 2068-2074
-
-
Albert, L.J.1
Inman, R.D.2
-
125
-
-
80155200721
-
Therapeutic siRNA silencing in inflammatory monocytes in mice
-
Leuschner, F. et al. Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat. Biotechnol. 29, 1005-1010 (2011).
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 1005-1010
-
-
Leuschner, F.1
-
126
-
-
84960882884
-
Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo
-
Yin, H. et al. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo. Nat. Biotechnol. 34, 328-333 (2016).
-
(2016)
Nat. Biotechnol.
, vol.34
, pp. 328-333
-
-
Yin, H.1
-
127
-
-
84879673266
-
Nanoengineering approaches to the design of artificial antigen-presenting cells
-
Sunshine, J. C. & Green, J. J. Nanoengineering approaches to the design of artificial antigen-presenting cells. Nanomedicine 8, 1173-1189 (2013).
-
(2013)
Nanomedicine
, vol.8
, pp. 1173-1189
-
-
Sunshine, J.C.1
Green, J.J.2
-
128
-
-
9744227933
-
Exosomes for cancer immunotherapy
-
Andre, F., Escudier, B., Angevin, E., Tursz, T. & Zitvogel, L. Exosomes for cancer immunotherapy. Ann. Oncol. 15, iv141-iv144 (2004).
-
(2004)
Ann. Oncol.
, vol.15
, pp. iv141-iv144
-
-
Andre, F.1
Escudier, B.2
Angevin, E.3
Tursz, T.4
Zitvogel, L.5
-
129
-
-
68849129712
-
Membrane vesicles as conveyors of immune responses
-
Théry, C., Ostrowski, M. & Segura, E. Membrane vesicles as conveyors of immune responses. Nat. Rev. Immunol. 9, 581-593 (2009).
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 581-593
-
-
Théry, C.1
Ostrowski, M.2
Segura, E.3
-
130
-
-
0141862085
-
MHC class I-mediated exogenous antigen presentation by exosomes secreted from immature and mature bone marrow derived dendritic cells
-
Utsugi-Kobukai, S., Fujimaki, H., Hotta, C., Nakazawa, M. & Minami, M. MHC class I-mediated exogenous antigen presentation by exosomes secreted from immature and mature bone marrow derived dendritic cells. Immunol. Lett. 89, 125-131 (2003).
-
(2003)
Immunol. Lett.
, vol.89
, pp. 125-131
-
-
Utsugi-Kobukai, S.1
Fujimaki, H.2
Hotta, C.3
Nakazawa, M.4
Minami, M.5
-
131
-
-
84906098610
-
Dendritic cell-derived exosomes as immunotherapies in the fight against cancer
-
Pitt, J. M. et al. Dendritic cell-derived exosomes as immunotherapies in the fight against cancer. J. Immunol. 193, 1006-1011 (2014).
-
(2014)
J. Immunol.
, vol.193
, pp. 1006-1011
-
-
Pitt, J.M.1
-
132
-
-
84962844515
-
Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC
-
Besse, B. et al. Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC. Oncoimmunology 5, e1071008 (2016).
-
(2016)
Oncoimmunology
, vol.5
, pp. e1071008
-
-
Besse, B.1
-
133
-
-
84992426115
-
Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy
-
Chen, Q. et al. Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Nat. Commun. 7, 13193 (2016).
-
(2016)
Nat. Commun.
, vol.7
, pp. 13193
-
-
Chen, Q.1
-
134
-
-
84937127869
-
Complement C3 mediated targeting of liposomes to granulocytic myeloid derived suppressor cells
-
Kullberg, M., Martinson, H., Mann, K. & Anchordoquy, T. J. Complement C3 mediated targeting of liposomes to granulocytic myeloid derived suppressor cells. Nanomedicine 11, 1355-1363 (2015).
-
(2015)
Nanomedicine
, vol.11
, pp. 1355-1363
-
-
Kullberg, M.1
Martinson, H.2
Mann, K.3
Anchordoquy, T.J.4
-
135
-
-
84864995694
-
Systemic RNAi-mediated gene silencing in nonhuman primate and rodent myeloid cells
-
Novobrantseva, T. I. et al. Systemic RNAi-mediated gene silencing in nonhuman primate and rodent myeloid cells. Molecular Therapy Nucleic Acids 1, e4 (2012).
-
(2012)
Molecular Therapy Nucleic Acids
, vol.1
, pp. e4
-
-
Novobrantseva, T.I.1
-
136
-
-
84988694000
-
Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues
-
Zanganeh, S. et al. Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues. Nat. Nanotech. 11, 986-994 (2016).
-
(2016)
Nat. Nanotech.
, vol.11
, pp. 986-994
-
-
Zanganeh, S.1
-
137
-
-
84948461699
-
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
-
Vétizou, M. et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 350, 1079-1084 (2015).
-
(2015)
Science
, vol.350
, pp. 1079-1084
-
-
Vétizou, M.1
-
138
-
-
84948451779
-
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti?PD?L1 efficacy
-
Sivan, A. et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti?PD?L1 efficacy. Science 350, 1084-1089 (2015).
-
(2015)
Science
, vol.350
, pp. 1084-1089
-
-
Sivan, A.1
-
139
-
-
84928761118
-
Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi, N. A. et al. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348, 124-128 (2015).
-
(2015)
Science
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
-
140
-
-
84982946696
-
Analysis of immune signatures in longitudinal tumor samples yields insight into biomarkers of response and mechanisms of resistance to immune checkpoint blockade
-
Chen, P. L. et al. Analysis of immune signatures in longitudinal tumor samples yields insight into biomarkers of response and mechanisms of resistance to immune checkpoint blockade. Cancer Discov. 6, 1-11 (2016).
-
(2016)
Cancer Discov.
, vol.6
, pp. 1-11
-
-
Chen, P.L.1
-
141
-
-
84950117835
-
Pembrolizumab versus docetaxel for previously treated, PD?L1?Positive, advanced non?Small?Cell lung cancer (KEYNOTE-010): A randomised controlled trial
-
Herbst, R. S. et al. Pembrolizumab versus docetaxel for previously treated, PD?L1?positive, advanced non?small?cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 387, 1540-1550 (2016).
-
(2016)
Lancet
, vol.387
, pp. 1540-1550
-
-
Herbst, R.S.1
-
142
-
-
84983535198
-
Moving programmed death-1 inhibitors to the front lines in non?Small?Cell lung cancer
-
Gainor, J. F. Moving programmed death-1 inhibitors to the front lines in non?small?cell lung cancer. J. Clin. Oncol. 34, 2953-2955 (2016).
-
(2016)
J. Clin. Oncol.
, vol.34
, pp. 2953-2955
-
-
Gainor, J.F.1
-
143
-
-
84862859820
-
Safety, activity, and immune correlates of anti?PD?1 antibody in cancer
-
Topalian, S. L. et al. Safety, activity, and immune correlates of anti?PD?1 antibody in cancer. N. Engl. J. Med. 366, 2443-2454 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
-
144
-
-
84857257866
-
Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes
-
St John, A. L. et al. Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes. Nat. Mater. 11, 250-257 (2012).
-
(2012)
Nat. Mater.
, vol.11
, pp. 250-257
-
-
St John, A.L.1
-
145
-
-
84927161447
-
Immunoengineering: How nanotechnology can enhance cancer immunotherapy
-
Goldberg, M. S. Immunoengineering: how nanotechnology can enhance cancer immunotherapy. Cell 161, 201-204 (2015).
-
(2015)
Cell
, vol.161
, pp. 201-204
-
-
Goldberg, M.S.1
-
146
-
-
84983565578
-
Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy
-
Sato, K. et al. Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy. Sci. Transl. Med. 8, 352ra110 (2016).
-
(2016)
Sci. Transl. Med.
, vol.8
, pp. 352ra110
-
-
Sato, K.1
-
147
-
-
84922939098
-
Nanopharmaceuticals (part 1): Products on the market
-
Weissig, V., Pettinger, T. K. & Murdock, N. Nanopharmaceuticals (part 1): products on the market. Int. J. Nanomedicine 9, 4357-4373 (2014).
-
(2014)
Int. J. Nanomedicine
, vol.9
, pp. 4357-4373
-
-
Weissig, V.1
Pettinger, T.K.2
Murdock, N.3
-
149
-
-
84934436071
-
Design rationale and development approach for pegfilgrastim as a long-acting granulocyte colony-stimulating factor
-
Arvedson, T., O'Kelly, J. & Yang, B. B. Design rationale and development approach for pegfilgrastim as a long-acting granulocyte colony-stimulating factor. BioDrugs 29, 185-198 (2015).
-
(2015)
BioDrugs
, vol.29
, pp. 185-198
-
-
Arvedson, T.1
O'Kelly, J.2
Yang, B.B.3
-
150
-
-
33747840618
-
Polymer conjugates as anticancer nanomedicines
-
Duncan, R. Polymer conjugates as anticancer nanomedicines. Nat. Rev. Cancer 6, 688-701 (2006).
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 688-701
-
-
Duncan, R.1
-
152
-
-
84866743713
-
Combination delivery of TGF-? Inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy
-
Park, J. et al. Combination delivery of TGF-? inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy. Nat. Mater. 11, 895-905 (2012).
-
(2012)
Nat. Mater.
, vol.11
, pp. 895-905
-
-
Park, J.1
-
153
-
-
77955337139
-
Anti?CD4?Targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice
-
Eck, W. et al. Anti?CD4?targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice. Nano Lett. 10, 2318-2322 (2010).
-
(2010)
Nano Lett.
, vol.10
, pp. 2318-2322
-
-
Eck, W.1
|