Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

Nature Nanotechnology

Volumn 8, Issue 10, 2013, Pages 772-781

  Tenzer, Stefan ^a   Docter, Dominic ^a   Kuharev, Jörg ^a   Musyanovych, Anna ^b,e   Fetz, Verena ^a   Hecht, Rouven ^c   Schlenk, Florian ^d   Fischer, Dagmar ^d   Kiouptsi, Klytaimnistra ^a   Reinhardt, Christoph ^a   Landfester, Katharina ^b   Schild, Hansjörg ^a   Maskos, Michael ^e   Knauer, Shirley K ^c   Stauber, Roland H ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b MAX PLANCK INSTITUTE FOR POLYMER RESEARCH   (Germany)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^e INSTITUT FÜR MIKROTECHNIK MAINZ GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; ENDOTHELIAL CELLS; MOLECULAR BIOLOGY; NANOPARTICLES; SILICA;

BIOLOGICAL FLUIDS; IN COMPOSITIONS; NANOPARTICLE UPTAKES; PATHOPHYSIOLOGY; PHYSIOLOGICAL SYSTEMS; POLYSTYRENE NANOPARTICLES; SURFACE FUNCTIONALIZATION; TIME-RESOLVED PROFILES;

PROTEINS;

ALPHA 1 ANTITRYPSIN; ALPHA 2 MACROGLOBULIN; APOLIPOPROTEIN A1; CERULOPLASMIN; COMPLEMENT COMPONENT C1R; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4A; COMPLEMENT FACTOR H; GELSOLIN; HAPTOGLOBIN; HEMOPEXIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; KININOGEN; NANOPARTICLE; PLASMA PROTEIN; POLYSTYRENE; SEROTRANSFERRIN; SERUM ALBUMIN; SILICON DIOXIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; ENDOTHELIUM CELL; HEMOLYSIS; MOLECULAR PATHOLOGY; NANOMEDICINE; NANOTOXICOLOGY; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; PROTEIN CORONA; PROTEIN STRUCTURE; PROTEOMICS; THROMBOCYTE ACTIVATION;

BLOOD PLATELETS; BLOOD PROTEINS; CELL DEATH; CELL LINE; COMPUTATIONAL BIOLOGY; ENDOTHELIAL CELLS; HUMANS; MICROSCOPY, CONFOCAL; MICROVESSELS; NANOPARTICLES; PARTICLE SIZE; POLYSTYRENES; SILICON DIOXIDE;

EID: 84885483569     PISSN: 17483387     EISSN: 17483395     Source Type: Journal    
DOI: 10.1038/nnano.2013.181     Document Type: Article

References (30)

1. Malozemoff, A. P. & Slonczewski, J. C. in Magnetic Domain Walls in Bubble Materials (Academic, 1979)
2. Jonietz, F. et al. Spin transfer torques in MnSi at ultralow current densities. Science 330, 1648-1651 (2010)
3. Yu, X. Z. et al. Skyrmion flow near room temperature in an ultralow current density. Nature Commun. 3, 988 (2012)
4. Iwasaki, J., Mochizuki, M. & Nagaosa, N. Universal current-velocity relation of skyrmion motion in chiral magnets. Nature Commun. 4, 1463 (2013)
5. Tchoe, Y. & Han, J. H. Skyrmion generation by current. Phys. Rev. B 85, 174416 (2012)
6. Finazzi, M. et al. Laser-induced magnetic nanostructures with tunable topological properties. Phys. Rev. Lett. 110, 177205 (2013)
7. Yu, X. Z. et al. Magnetic stripes and skyrmions with helicity reversals. Proc. Natl Acad. Sci. USA 109, 8856-8860 (2012)
8. Everschor, K. et al. Rotating skyrmion lattices by spin torques and field or temperature gradients. Phys. Rev. B 86, 054432 (2012)
9. Schulz, T. et al. Emergent electrodynamics of skyrmions in a chiral magnet. Nature Phys. 8, 301-304 (2012)
10. Kla?ui, M. et al. Direct observation of domain-wall pinning at nanoscale constrictions. Appl. Phys. Lett. 87, 102509 (2005)
11. Martinez, E. et al. Thermal effects on domain wall depinning from a single notch. Phys. Rev. Lett. 98, 267202 (2007)
12. Jang, Y. et al. Current-induced domain wall nucleation and its pinning characteristics at a notch in a spin-valve nanowire. Nanotechnology 20, 125401 (2009)
13. Fert, A., Cros, V. & Sampaio, J. Skyrmions on the track. Nature Nanotech. 8, 152-156 (2013)
14. Shibata, J. et al. Current-induced magnetic vortex motion by spin-transfer torque. Phys. Rev. B 73, 020403 (2006)
15. Guslienko, K. et al. Magnetic vortex core dynamics in cylindrical ferromagnetic dots. Phys. Rev. Lett. 96, 067205 (2006)
16. Liu, Y. et al. Current-induced magnetic vortex core switching in a permalloy nanodisk. Appl. Phys. Lett. 91, 112501 (2007)
17. Wysin, G. Magnetic vortex mass in two-dimensional easy-plane magnets. Phys. Rev. B 54, 15156-15162 (1996)
18. Yamada, K. et al. Electrical switching of the vortex core in a magnetic disk. Nature Mater. 6, 269-273 (2007)
19. Zienkiewicz, O. C., Taylor, R. L. & Zhu, J. Z. in The Finite Element Method: Its Basis and Fundamentals (Elsevier Butterworth-Heinemann, 2005)
20. Rivera Gil, P., Oberdo?rster, G., Elder, A., Puntes, V. & Parak, W. J. Correlating physico-chemical with toxicological properties of nanoparticles: the present and the future. ACS Nano 4, 5527-5531 (2011)
21. Schousboe, I. & Nystrom, B. High molecular weight kininogen binds to laminin-characterization and kinetic analysis. FEBS J. 276, 5228-5238 (2009)
22. Zensi, A. et al. Human serum albumin nanoparticles modified with apolipoprotein A-I cross the blood-brain barrier and enter the rodent brain. J. Drug Target. 18, 842-848 (2010)
23. Zensi, A. et al. Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones. J. Control. Release 137, 78-86 (2009)
24. Aggarwal, P., Hall, J. B., McLeland, C. B., Dobrovolskaia, M. A. & McNeil, S. E. Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. Adv. Drug Deliv. Rev. 61, 428-437 (2009)
25. Reinhardt, C. et al. Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling. Nature 483, 627-631 (2011)
26. Engels, K. et al. NO signaling confers cytoprotectivity through the survivin network in ovarian carcinomas. Cancer Res. 68, 5159-5166 (2008)
27. Knauer, S. K. et al. Functional characterization of novel mutations affecting survivin (BIRC5)-mediated therapy resistance in head and neck cancer patients. Hum. Mutat. 34, 395-404 (2012)
28. Bier, C. et al. Allosteric inhibition of Taspase1?s pathobiological activity by enforced dimerization in vivo. FASEB J. 26, 3421-3429 (2012)
29. Bauer, M. et al. Poly(2-ethyl-2-oxazoline) as alternative for the stealth polymer poly(ethylene glycol): comparison of in vitro cytotoxicity and hemocompatibility. Macromol. Biosci. 12, 986-998 (2012)
30. Tenzer, S. et al. Proteome-wide characterization of the RNA-binding protein RALY-interactome using the in vivo-biotinylation-pulldown-quant (iBioPQ) approach. J. Proteome Res. 12, 2869-2884 (2013)