Predicting chemotherapy toxicity in older adults with cancer: A prospective multicenter study

Journal of Clinical Oncology

Volumn 29, Issue 25, 2011, Pages 3457-3465

  Hurria, Arti ^a   Togawa, Kayo ^a   Mohile, Supriya G ^c   Owusu, Cynthia ^g   Klepin, Heidi D ^h   Gross, Cary P ⁱ   Lichtman, Stuart M ^d   Gajra, Ajeet ^f   Bhatia, Smita ^a   Katheria, Vani ^j   Klapper, Shira ^d   Hansen, Kurt ^b   Ramani, Rupal ^a   Lachs, Mark ^e   Wong, F Lennie ^a   Tew, William P ^d  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

^f SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^g CASE WESTERN RESERVE UNIVERSITY   (United States)

^h WAKE FOREST SCHOOL OF MEDICINE   (United States)

ⁱ YALE CANCER CENTER   (United States)

^j GEORGETOWN UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

AGED; ANEMIA; BREAST CANCER; CANCER CENTER; CANCER CHEMOTHERAPY; CANCER GRADING; CANCER RISK; CANCER THERAPY; CLINICAL ASSESSMENT; COGNITION; COMORBIDITY; CONFERENCE PAPER; DEHYDRATION; DEMOGRAPHY; DIGESTIVE SYSTEM CANCER; DRUG DOSE REDUCTION; DRUG TOXICITY; FATIGUE; FEMALE; GERIATRIC ASSESSMENT; GYNECOLOGIC CANCER; HUMAN; INFECTION; LABORATORY TEST; LEUKOPENIA; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEOPLASM; NEUTROPENIA; NUTRITIONAL STATUS; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSYCHOLOGIC ASSESSMENT; RISK FACTOR; SOCIAL BEHAVIOR; STRATIFIED SAMPLE; UROGENITAL TRACT CANCER;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMORBIDITY; FEMALE; FOLLOW-UP STUDIES; HUMANS; LONGITUDINAL STUDIES; MALE; NEOPLASMS; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 80052704591     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2011.34.7625     Document Type: Conference Paper

References (42)

1. Smith BD, Smith GL, Hurria A, et al: Future of cancer incidence in the United States: Burdens upon an aging, changing nation. J Clin Oncol 27:2758-2765, 2009
2. Hutchins LF, Unger JM, Crowley JJ, et al: Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 341:2061-2067, 1999 (Pubitemid 30035956)
3. Talarico L, Chen G, Pazdur R: Enrollment of elderly patients in clinical trials for cancer drug registration: A 7-year experience by the US Food and Drug Administration. J Clin Oncol 22:4626-4631, 2004 (Pubitemid 41185131)
4. Muss HB, Woolf S, Berry D, et al: Adjuvant chemotherapy in older and younger women with lymph node-positive breast cancer. JAMA 293:1073-1081, 2005 (Pubitemid 40300281)
5. Sargent DJ, Goldberg RM, Jacobson SD, et al: A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med 345:1091-1097, 2001
6. Muss HB, Berry DA, Cirrincione C, et al: Toxicity of older and younger patients treated with adjuvant chemotherapy for node-positive breast cancer: The Cancer and Leukemia Group B Experience. J Clin Oncol 25:3699-3704, 2007 (Pubitemid 47372610)
7. Hurria A, Wong FL, Villaluna D, et al: Role of age and health in treatment recommendations for older adults with breast cancer: The perspective of oncologists and primary care providers. J Clin Oncol 26:5386-5392, 2008
8. Kornblith AB, Kemeny M, Peterson BL, et al: Survey of oncologists' perceptions of barriers to accrual of older patients with breast carcinoma to clinical trials. Cancer 95:989-996, 2002 (Pubitemid 34925347)
9. Ravdin PM, Siminoff LA, Davis GJ, et al: Computer program to assist in making decisions about adjuvant therapy for women with early breast cancer. J Clin Oncol 19:980-991, 2001 (Pubitemid 32176272)
10. Karnofsky DA, Burchenal JH: The clinical evaluation of chemotherapeutic agents in cancer, in Macleod CM (ed): Evaluation of Chemotherapeutic Agents. New York, NY, Columbia University Press, 1948, pp 191-205
11. Zubrod C, Schneiderman M, Frei E III, et al: Appraisal of methods for the study of chemotherapy of cancer in man: Comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide. J Chron Dis 11:7-33, 1960
12. Bajorin DF, Dodd PM, Mazumdar M, et al: Long-term survival in metastatic transitional-cell carcinoma and prognostic factors predicting outcome of therapy. J Clin Oncol 17:3173-3181, 1999 (Pubitemid 29470648)
13. Motzer RJ, Bacik J, Schwartz LH, et al: Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma. J Clin Oncol 22:454-463, 2004 (Pubitemid 41079774)
14. Albain KS, Crowley JJ, LeBlanc M, et al: Survival determinants in extensive-stage non-small-cell lung cancer: The Southwest Oncology Group experience. J Clin Oncol 9:1618-1626, 1991
15. Extermann M, Hurria A: Comprehensive geriatric assessment for older patients with cancer. J Clin Oncol 25:1824-1831, 2007 (Pubitemid 46860271)
16. Hurria A, Gupta S, Zauderer M, et al: Developing a cancer-specific geriatric assessment: A feasibility study. Cancer 104:1998-2005, 2005 (Pubitemid 41513186)
17. Lindeman RD, Tobin J, Shock NW: Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 33:278-285, 1985 (Pubitemid 15087125)
18. Reuben DB, Rubenstein LV, Hirsch SH, et al: Value of functional status as a predictor of mortality: Results of a prospective study. Am J Med 93:663-669, 1992
19. Stewart AL, Ware JE Jr: Measuring Functioning and Well-Being: The Medical Outcomes Study Approach. Durham, NC, Duke University Press, 1992
20. Fillenbaum GG, Smyer MA: The development, validity, and reliability of the OARS multidimensional functional assessment questionnaire. J Gerontol 36:428-434, 1981 (Pubitemid 11070078)
21. Zigmond AS, Snaith RP: The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361-370, 1983 (Pubitemid 13098606)
22. Loprinzi CL, Laurie JA, Wieand HS, et al: Prospective evaluation of prognostic variables from patient-completed questionnaires: North Central Cancer Treatment Group. J Clin Oncol 12:601-607, 1994 (Pubitemid 24079905)
23. Sherbourne CD, Stewart AL: The MOS social support survey. Soc Sci Med 32:705-714, 1991
24. Podsiadlo D, Richardson S: The timed "Up &Go": A test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39:142-148, 1991
25. Kawas C, Karagiozis H, Resau L, et al: Reliability of the Blessed Telephone Information-Memory-Concentration Test. J Geriatr Psychiatry Neurol 8:238-242, 1995
26. National Comprehensive Cancer Network: NCCN Practice Guidelines in Oncology, 2010. http://www.nccn.org/professionals/physician-gls/f-guidelines.asp
27. National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE), Version 3.0. http://ctep.cancer.gov/protocoldevelopment/electronic- applications/docs/ctcaev3.pdf
28. Cockcroft DW, Gault MH: Prediction of creatinine clearance from serum creatinine. Nephron 16:31-41, 1976
29. Jelliffe RW: Estimation of creatinine clearance when urine cannot be collected. Lancet 1:975-976, 1971
30. Levey AS, Bosch JP, Lewis JB, et al: A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation - Modification of Diet in Renal Disease Study Group. Ann Intern Med 130:461-470, 1999 (Pubitemid 29135798)
31. Wright JG, Boddy AV, Highley M, et al: Estimation of glomerular filtration rate in cancer patients. Br J Cancer 84:452-459, 2001 (Pubitemid 32215868)
32. Youden WJ: Index for rating diagnostic tests. Cancer 3:32-35, 1950
33. Hocking RR, Leslie RN: Selection of the best subset in regression analysis. Technometrics 9:531-540, 1967
34. Hosmer DW, Lemeshow S: Applied Logistic Regression. New York, NY, Wiley, 2000
35. Concato J, Feinstein AR, Holford TR: The risk of determining risk with multivariable models. Ann Intern Med 118:201-210, 1993 (Pubitemid 23034807)
36. Walter LC, Brand RJ, Counsell SR, et al: Development and validation of a prognostic index for 1-year mortality in older adults after hospitalization. JAMA 285:2987-2994, 2001 (Pubitemid 32550117)
37. Hastie T, Tibshirani R, Friedman J (eds): The Elements of Statistical Learning: Data Mining, Inference, and Prediction (ed 2). New York, NY, Springer, 2009
38. Olsen DL, Denlen D (eds): Advanced Data Mining Techniques. New York, NY, Springer, 2008
39. Dees EC, O'Reilly S, Goodman SN, et al: A prospective pharmacologic evaluation of age-related toxicity of adjuvant chemotherapy in women with breast cancer. Cancer Invest 18:521-529, 2000 (Pubitemid 30485668)
40. Gómez H, Hidalgo M, Casanova L, et al: Risk factors for treatment-related death in elderly patients with aggressive non-Hodgkin's lymphoma: Results of a multivariate analysis. J Clin Oncol 16:2065-2069, 1998 (Pubitemid 28265042)
41. Repetto L, Carreca I, Maraninchi D, et al: Use of growth factors in the elderly patient with cancer: A report from the Second International Society for Geriatric Oncology (SIOG) 2001 meeting. Crit Rev Oncol Hematol 45:123-128, 2003 (Pubitemid 36216309)
42. Izaks GJ, Westendorp RG, Knook DL: The definition of anemia in older persons. JAMA 281:1714-1717, 1999 (Pubitemid 29226481)